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Amélia M. Lopes Dias da Silva is currently a Full Professor at the Department of Biology and Environment, School of Life and Environmental Sciences at the University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal (http://www.utad.pt/). Academic degrees (and titles): Habilitation in Chemical and Biological Sciences in 2021 at UTAD; PhD in Biochemistry (specialty in Cellular Biophysics) at the Faculty of Sciences and Technology of University of Coimbra (FCTUC) in 2003 (in collaboration with Washington University in St. Louis, USA); MSc in Cell Biology at FCTUC in 1995; Graduation in Biochemistry at FCTUC in 1992. Areas of expertise: Biochemistry; Cell Physiology; Cell and molecular biology; Nanotechnology and nanotoxicology; Phytochemicals; Antioxidant activity (cellular level); Cell survival and death pathways. My academic career started as a Lecturer at UTAD in 1996. I was hired as Assistant Professor in 2003, and as Associate Professor in 2021. I signed a Full Professor contract with UTAD, in April 2023, which is my current position. My teaching experience includes classes for the 3 education levels (>37 different curricular units taught; teacher in charge of >150 UCs). I have supervised 2 Post-Docs, 8 PhDs, 38 MSc, 46 BSc Internships, 6 Research Scholarships (currently supervising several students). I have also been member of academic committees/juries: 22 PhD, 74 MSc, 96 BSc; and of recruiting staff (scientific, academic and other). Regarding R&D Units, I have been an integrated member of the Centre for the Research and Technology of Agro-environmental and Biological Sciences (CITAB) since 2007, and currently the Vice-Director (since August 2022). As integrated member, I have been part of its Scientific Council. From 2011-2014, I coordinated the group “Food Composition and Health Effects”; Currently, I am the “Biochemistry and Cell Biology Lab” group leader. Concerning scientific indicators, I was coordinator/member of 12 R&D projects/contracts (+7 RU funding). I am an author in >170 SCOPUS-indexed publications (h-index 47, https://orcid.org/0000-0002-7524-9914), 36 book chapters, >200 proceedings/abstracts in scientific meetings. I have been editor/guest editor in 4 journals, reviewer for >50 index journals; external evaluator of >25 scientific projects/grants. Further curricular information can be found on the links below: ORCID: https://orcid.org/0000-0002-7524-9914 SCOPUS: https://www.scopus.com/authid/detail.uri?authorId=35578752300 Ciência Vitae: https://www.cienciavitae.pt//241E-3956-0242 ReserchGate: https://www.researchgate.net/profile/Amelia-Silva-3
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Identification

Personal identification

Full name
Amélia Maria Lopes Dias da Silva

Author identifiers

Ciência ID
241E-3956-0242
ORCID iD
0000-0002-7524-9914

Email addresses

  • amsilva@utad.pt (Professional)

Addresses

  • Universidade de Trás-os-Montes e Alto Douro, Escola de Ciências da Vida e do Ambiente, Departamento de Biologia e Ambiente. Departamento de Biologia (CP:1013), 5001-801, Vila Real, Vila Real, Portugal (Professional)
  • University of Trás-os-Montes e Alto Douro. Dep. of Biology and Environment; Quinta de Prados, 5000-911, Vila Real, Vila Real, Portugal (Professional)
Education
Degree Classification
2021/07/05 - 2021/07/06
Concluded
 Agregação em Ciências Químicas e Biológicas / Habilitation in Chemical and Biological Sciences (Título de Agregado)
Universidade de Trás-os-Montes e Alto Douro, Portugal
 Aprovado por unanimidade
2003/03/20
Concluded
 Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Receptores P2 e modulação da actividade secretora da célula beta-pancreática / P2 receptors and modulation of pancreatic beta cell secretory activity" (THESIS/DISSERTATION)
 Muito Bom /Louvor e distinção
1992 - 1995
Concluded
 Biologia Celular (Mestrado)
Universidade de Coimbra, Portugal
"Via de influxo de Ca2+ insensível a di-hidropiridinas na célula beta pancreática" (THESIS/DISSERTATION)
 Muito Bom
1987 - 1992
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra, Portugal
"Regulação da secreção de insulina: papel do Ca2+ intracelular" (THESIS/DISSERTATION)
 15
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2023/04/14 - Current Full Professor (University Teacher) Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/04/29 - 2023/04/14 Associate Professor (University Teacher) Universidade de Trás-os-Montes e Alto Douro, Portugal
2008/03/20 - 2021/04/28 Assistant Professor (University Teacher) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2003/03 - 2008/03/20 Assistant Professor (University Teacher) Universidade de Trás-os-Montes e Alto Douro, Portugal

Positions / Appointments

Category
Host institution 		Employer
2017/03/13 - Current Conselho científico/técnico-científico ou orgão correspondente Universidade de Trás-os-Montes e Alto Douro, Portugal
Projects

Grant

Designation Funders
2021/01/01 - 2024/06/30 Fungi4Health - Valorization of agro-industrial residues in the production of mushrooms and in the development of functional foods and value-added products (NORTE-01-0247-FEDER-070171)
NORTE-01-0247-FEDER-070171
Research Fellow
Agência Nacional de Inovação SA
Concluded

Contract

Designation Funders
2018/07/01 - 2021/06/30 SafeNPest - Synthesis and Environmental Safety of Nanopesticides
PTDC/ASP-AGR/29343/2017
Researcher
Universidade do Porto, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2021/06/30 “FungiTech -Tecnologia e inovação na cadeia de produção do shiitake e de outros cogumelos com valor nutracêutico e medicinal”
QREN-2020
Researcher
Universidade de Trás-os-Montes e Alto Douro, Portugal
Ongoing
2016/10/01 - 2020/03/31 Magnetically and photochemically actuated bioactive nanowires for remotely controlled drug delivery
M-ERA-NET/0004/2015
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/12/31 INTERACT-ISAC: “Integrative Research in Environment, Agro-Chains and Technology
NORTE-01-0145-FEDER-000017
Researcher
Universidade de Trás-os-Montes e Alto Douro, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal
European Regional Development Fund
Concluded
2010/01/01 - 2015/03/30 PromoAgro - Promoção da Competitividade Agro-alimentar
NORTE-01-0162-FEDER-000043
Researcher
Universidade de Trás-os-Montes e Alto Douro, Portugal
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 4016 - 2011-2012
PEst-OE/CED/UI4016/2011
PEst-C/AGR/UI4033/2011
Instituto Politécnico de Viseu, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Politécnico de Viseu Centro de Estudos em Educação Tecnologia e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/05/01 - 2013/04/30 NanoSKIN: Chemotherapeutic agent-loaded nanoparticles for innovative therapy of severe skin diseases - muco-/cutaneous Leishmaniasis and squamous cell carcinoma as examples
ERA-Eula/0002/2009
Provided by PTCRIS: 116318
Universidade de Trás-os-Montes e Alto Douro, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2015/10/01 - 2019/12/31 Iberphenol - Red cooperativa de investigación en el ámbito de polifenoles y sus aplicaciones industriales
0377_IBERPHENOL_6_E
Researcher
Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal
Concluded
Outputs

Publications

Book
  1. Souto, E.B.; Sampaio, A.C.; Campos, J.R.; Martins-Gomes, C.; Aires, A.; Silva, A.M.; Souto, Eliana B.; et al. Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems. Elsevier. 2019.
    10.1016/B978-0-12-817901-7.00002-2
Book chapter
  1. Martins-Gomes, C.; Souto, E.B.; Silva, A.M.. "Nanophytosomes: a novel approach for the delivery of herbal drugs". 239-257. 2022.
  2. Amélia M. Silva; Ana T. Cruz; Joana Nobre; Tiago E. Coutinho ; Amanda Cano; Aleksandra Zielinska; Anðelka Kova¿cevic; Patricia Severino; Eliana B. Souto. Corresponding author: Amélia M. Silva. "Lipid nanoparticles-based semisolid formulations for cosmetic applications: focus on cellulite". In Nanotechnology and Regenerative Medicine, edited by Maria Santana; Eliana B. Souto; Ranjita Shegokar, 179-193. ELSEVIER, 2022.
    Published
  3. Pashirova, Tatiana N.; Fernandes, Ana R.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amélia M.; Zakharova, Lucia Ya.; Souto, Eliana B.; et al. "Polymer nanogels: Fabrication, structural behavior, and biological applications". In Theory and Applications of Nonparenteral Nanomedicines, 97-111. Elsevier, 2021.
    Published • 10.1016/b978-0-12-820466-5.00005-3
  4. Souto, Eliana B.; Fernandes, A. R.; Ferreira, J. Dias; da Silva, C. F.; Severino, Patrícia; Martins-Gomes, Carlos; Silva, Amélia M.. "Multifunctional Nanocomposites for Biotherapeutic Applications". In Research Anthology on Synthesis, Characterization, and Applications of Nanomaterials, 1444-1472. IGI Global, 2021.
    Published • 10.4018/978-1-7998-8591-7.ch060
  5. Fernandes, A.R.; Dias-Ferreira, J.; Teixeira, M.C.; Shimojo, A.A.M.; Severino, Patrícia; Silva, A.M.; Shegokar, Ranjita; Souto, Eliana B.. "Bioactive hybrid nanowires: a new in trend for site-specific drug delivery and targeting.". In Drug Delivery Trends, 1-13. Elsevier, 2020.
    Published • 10.1016/b978-0-12-817870-6.00001-8
  6. Fernandes, A.R.; Dias-Ferreira, J.; Teixeira, M.C.; Shimojo, A.A.M.; Severino, P.; Silva, A.M.; Shegokar, R.; Souto, E.B.. "Bioactive hybrid nanowires: a new in trend for site-specific drug delivery and targeting". 1-13. 2020.
  7. Campos, J.R.; Severino, P.; Santini, A.; Silva, A.M.; Shegokar, R.; Souto, S.B.; Souto, E.B.; Shegokar, Ranjita. "Solid lipid nanoparticles (SLN): Prediction of toxicity, metabolism, fate and physicochemical properties. prediction of toxicity, metabolism, fate and physicochemical properties.". In Nanopharmaceuticals, 1-15. Elsevier, 2020.
    Published • 10.1016/b978-0-12-817778-5.00001-4
  8. Carlos Martins-Gomes; Fernando M. Nunes; Ana C. Sampaio; Eliana B. Souto; Amélia M Silva. Corresponding author: Amélia M Silva. "Rosmarinic Acid: Sources, Bioactivities and Health Benefits.". In Phytochemicals: Plant Sources and Potential Health Benefits, edited by Iman Ryan, 109-146. NovaScience Publishers, 2019.
    Published
  9. Pereira, Irina; Antunes, Sara; Santos, Ana C.; Veiga, Francisco J.; Silva, Amélia M.; Boonme, Prapaporn; Souto, Eliana B.. "Microemulsions: Principles, Scope, Methods, and Applications in Transdermal Drug Delivery". In Nanotechnology and Nanomaterial Applications in Food, Health, and Biomedical Sciences, 91-118. Apple Academic Press, 2019.
    Published • 10.1201/9780429425660-2
  10. Vieira, Raquel; Fortuna, Ana C.; Silva, Amélia M.; Souto, Selma B.; Souto, Eliana B.; Vieira, R.; Fortuna, A.C.; et al. "Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff". In Advances in Processing Technologies for Bio-based Nanosystems in Food, 211-230. CRC Press, 2019.
    Published • 10.1201/9781315177328-10
  11. Zielinska, A.; Pereira, I.; Antunes, S.; Veiga, F.J.; Santos, A.C.; Nowak, I.; Silva, A.M.; Souto, E.B.. "Mesoporous silica nanoparticles as drug delivery systems against melanoma". In Design of Nanostructures for Theranostics Applications, 437-466. -: Elsevier, 2018.
    Published • 10.1016/B978-0-12-813669-0.00010-5
  12. Fernandes, Ana R.; Martins-Gomes, Carlos; Santini, Antonello; SILVA, Amélia M.; Souto, Eliana B.; Fernandes, A.R.; Martins-Gomes, C.; et al. "Psoriasis vulgaris—Pathophysiology of the disease and its classical treatment versus new drug delivery systems". In Design of Nanostructures for Versatile Therapeutic Applications, 379-406. -: Elsevier, 2018.
    Published • 10.1016/B978-0-12-813667-6.00009-7
  13. Teixeira, M.C.; Martins-Gomes, C.; Singh, K.K.; Veiga, F.J.; Silva, A.M.; Souto, E.B.. "Targeting of Lipid/Polymeric (Hybrid) Nanoparticles to the Brain for the Treatment of Degenerative Diseases". In Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors, 147-168. -: Elsevier, 2018.
    Published • 10.1016/B978-0-12-812218-1.00006-3
  14. Teixeira, M.C.; Sanchez-Lopez, E.; Espina, M.; Calpena, A.C.; Silva, Amelia M.; Veiga, F.J.; Garcia, M.L.; et al. "Advances in antibiotic nanotherapy". In Emerging Nanotechnologies in Immunology, 233-259. -: Elsevier, 2018.
    Published • 10.1016/B978-0-323-40016-9.00009-9
  15. Martins-Gomes, Carlos; SILVA, Amélia M.. "Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents". In Teratogenicity Testing, 191-203. New York, NY: Springer New York, 2018.
    Published • 10.1007/978-1-4939-7883-0_9
  16. Souto, E.B.; Fernandes, A.R.; Dias Ferreira, J.; Da Silva, C.F.; Severino, P.; Martins-Gomes, C.; Silva, A.M.; et al. "Multifunctional nanocomposites for biotherapeutic applications". In Multifunctional Nanocarriers for Contemporary Healthcare Applications, 328-356. -: IGI Global, 2018.
    Published
  17. Fernandes, Ana R.; Dias-Ferreira, João; Ferreira-da-Silva, Classius; Severino, Patrícia; Martins-Gomes, Carlos; Silva, Amélia M.; Souto, Eliana B.; et al. "Drug nanocrystals: present, past and future". In Applications of Nanocomposite Materials in Drug Delivery, 239-253. -: Elsevier, 2018.
    Published • 10.1016/b978-0-12-813741-3.00011-x
  18. Irina Pereira; Aleksandra Zielinska; Francisco J. Veiga; Ana C. Santos; Izabela Nowak; Amélia M. Silva; Eliana B. Souto. "Monoterpenes based pharmaceuticals – A Review of Applications in Human Health and Drug Delivery Systems.". In Plant- and Marine-Based Phytochemicals for Human Health: Attributes, Potential, and Use, edited by Megh R. Goyal; Durgesh Nandini Chauhan, 85-130. Apple Academic Press, USA, CRC Taylor & Francis, 2018.
    Published
  19. Silva, A.M.; Siopa, J.R.; Martins-Gomes, C.; Teixeira, M.C.; Santos, D.J.; Pires, M.D.A.; Andreani, T.; et al. "New strategies for the treatment of autoimmune diseases using nanotechnologies". In Emerging Nanotechnologies in Immunology, 135-163. -: Elsevier, 2018.
    Published
  20. Zakharova, L.Y.; Pashirova, T.N.; Fernandes, A.R.; Doktorovova, S.; Martins-Gomes, C.; Silva, A.M.; Souto, E.B.; et al. "Self-assembled quaternary ammonium surfactants for pharmaceuticals and biotechnology". In Organic Materials as Smart Nanocarriers for Drug Delivery, 601-618. -: Elsevier, 2018.
    Published
  21. Andreani, Tatiana; Severino, Patrícia; de Hollanda, Luciana M.; Vazzana, Monica; Souto, Selma B.; Santini, Antonello; Silva, Amélia M.; et al. "Cancer therapies: applications, nanomedicines and nanotoxicology". In Nanostructures for Cancer Therapy, 241-260. Elsevier: Elsevier, 2017.
    Published • 10.1016/B978-0-323-46144-3.00009-X
  22. Leal, Fernanda; Taghouti, Meriem; Nunes, Fernando; Silva, Amélia M.; Coelho, Ana Cl?udia; Matos, Manuela. "Thymus Plants: A Review?Micropropagation, Molecular and Antifungal Activity". In Active Ingredients from Aromatic and Medicinal Plants, 107-126. 1: InTech, 2017.
    Published • 10.5772/66623
  23. Sampaio, A.C.; Aires, A.; Souto, E.B.; Silva, A.M.. "Essential Oils, Polyphenols and Glycosides: Secondary Plant Metabolites Against Microbes". In Frontiers in Clinical Drug Research-Anti Infectives, 136-186. -: BENTHAM SCIENCE PUBLISHERS, 2017.
    Published • 10.2174/97816810836981170301
  24. M. L. F. M. Pacheco; S. F. P. Friães; Renato Boto; Paulo Jorge da Silva Almeida; A. M. Silva; Lucinda V. Reis, L. V. Reis, L. Reis. "Synthesis of a Squarylium Cyanine Dye as Potential Photosensitizer for Photodynamic Therapy (PDT), 77, 342-346.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 301-305. Royal Society of Chemistry, 2017.
    Published
  25. Fangueiro, Joana F.; Souto, Eliana B.; Silva, Amélia M.. "Encapsulation of nutraceuticals in novel delivery systems". In Nutraceuticals, 305-342. Elsevier: Elsevier, 2016.
    Published • 10.1016/B978-0-12-804305-9.00009-9
  26. Severino, Patrícia; de Hollanda, Luciana M.; Santini, Antonello; Reis, Lucinda V.; Souto, Selma B.; Souto, Eliana B.; Silva, Amélia M.. "Advances in nanobiomaterials for oncology nanomedicine". In Nanobiomaterials in Cancer Therapy, 91-115. Elsevier: Elsevier, 2016.
    Published • 10.1016/B978-0-323-42863-7.00004-9
  27. Severino, P.; Fangueiro, J.F.; Chaud, M.V.; Cordeiro, J.; Silva, A.M.; Souto, E.B.; Severino, Patrícia; et al. "Advances in nanobiomaterials for topical administrations: new galenic and cosmetic formulations". In Nanobiomaterials in Galenic Formulations and Cosmetics, 1-23. Elsevier: Elsevier, 2016.
    Published
  28. Andreani, T.; Venkatesh, N.; Ferreira, S.V.; Silva, A.M.; Souto, E.B.. "Emerging Technologies of Polymers for Nanomedicine Applications". In Nanotechnology and Drug Delivery, Volume Two: Nano-Engineering Strategies and Nanomedicines against Severe Diseases, edited by J. L. Arias Mediano, 1-19. CRC Press, 2016.
    Published
  29. Vieira, V.; Silva, A.M.; Souto. E.B.. "Analysis of Theragnostic Tools by Raman Spectroscopy". In Nanotechnology Techniques: Review of specific applications of technical methods for nanotechnology research. In Series on Nanotechnology, 223-242. 2014.
    Published
  30. Andreani, T.; Silva, A.M.; Souto, E.B.. "Cell scaffolds and fabrication technologies for tissue engineering". In Advanced Functional Polymers and Composites: Materials, Devices and Allied Applications, edited by M.P. Inamuddin, 212-232. 2013.
    Published
  31. Andreani, Tatiana; Souza, Ana Luiza R.; SILVA, Amélia M.; Souto, Eliana B.. "Sol–Gel Carrier System: A Novel Controlled Drug Delivery". In Patenting Nanomedicines, 151-166. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012.
    Published • 10.1007/978-3-642-29265-1_5
  32. Santos, R.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A. M.; Salgado, A. P.; Abrunhosa, A.J.; Pereira, F.C.; et al. "Bursting electrical activity generated in the presence of the K-ATP channel blockers: pharmacology, sensitivity to intracellular pH and modulation by glucose metabolism". In Advances in experimental medicine and biology, 33-41. Plenum Publishing Corp., 1997.
    Published
  33. SANTOS, Rosa M.; Barbosa, Rui M.; Silva, Amélia M.; Antunes, Célia M.; Rosario, Luis M.. "[Ca2+]i-sensitive conductance in the regulation of pancreatic b-cell bursting". In Frontiers of Insulin Secretion and Pancreatic b-cell Research, 181-186. U.K.: Smith-Gordon, 1994.
    Published
Conference abstract
  1. Taghouti, M.; Martins-Gomes, C.; Santos, J. A.; Nunes, F. M.; Amélia M. Silva. "Chemical characterization and bioactivity of hydroethanolic extracts from three thyme species". Paper presented in Jornadas de Biologia, Vila Real, 2016.
    Published
  2. Vieira, V.; Fangueiro, J. F.; Silva, A. M.; Souto, E.B.; Silva, A.M.. "Characterization of the physicochemical performance of nimesulide-loaded lipid nanoparticulates". Paper presented in 3rd Scientific Meeting of the Institute for Biotechnology and Bioengineering, Lisbon, 2012.
    Published
Conference paper
  1. Ferreira, Sandra Filipa Vaz; Tatiana Andreani; Slavomira Doktorovová; Joana F. Fangueiro; Amélia M. Silva; Eliana B. Souto; Ferreira, Sandra, F.; et al. "PARSOL® MCX LOADED LIPID-SILICA NANOPARTICLES: AN INNOVATIVE SUNSCREEN APPROACH". Paper presented in 9th Central European Symposium of Pharmaceutical Tecnology, Dubrovnik, 2012.
    Published
Conference poster
  1. Frazão, David F.; Delgado, Fernanda; Carlos Martins-Gomes; Prof. Doutor José Carlos Gonçalves (IPCB-ESA); Amélia M. Silva. Corresponding author: Frazão, David F.. "A resina de esteva como ingrediente para produtos cosméticos e cosmacêuticos: avaliação de propriedades in vitro. / Rockrose resin as an ingredient for cosmetic and cosmaceutical products: evaluation of in vitro properties.". Paper presented in Congresso Nacional dos Recursos Silvestres, 2023.
  2. Ana Abraão; Nelson Fernandes; Rui Dias Costa; Irene Gouvinhas; Amélia M. Silva; Raúl Domínguez-Perles; Ana Barros. "Prunus lusitanica L. fruits as factories of compounds with bioactive potential". Paper presented in Dare2Change ¿ Innovation ¿ Driven Agrifood Bussiness, 2023.
  3. Frazão, David; Gonçalves, J. C.; Amélia M. Silva; Delgado, F.. Corresponding author: Delgado, F.. "Cultivo da esteva como nova abordagem à sua valorização / Cultivation of rockrose as a new approach to its valorization". Paper presented in IV Congresso Nacional das Escolas Superiores Agrárias, 2022.
  4. Coutinho, Tiago E.; Eliana B. Souto; Amélia M. Silva. "Antioxidant activity of a class of flavonoids present in aromatic and medicinal plants". Paper presented in III Colóquio Nacional de Plantas Aromáticas e Medicinais, 2022.
  5. Tiago E. Coutinho ; Amélia M. Silva. "Potential of Natural Flavonoids in skin photoprotection". Paper presented in XXI EuroFoodChem em On-line Conference, 2021.
  6. Tiago E. Coutinho ; Carlos Martins-Gomes; Fernando M. Nunes; Amélia M. Silva. "From oxidative stress protection to cell cycle arrest: Cucurbita ficifolia Bouché effects". Paper presented in Online Congress on Natural products application: Health, Cosmetic and Food, 2021.
  7. Coutinho, T.E.; Amélia M. Silva; Fernando M. Nunes. "Caracterização e quantificação de açúcares presentes na abóbora de chila através de cromatografia iónica.". Paper presented in XXV Encontro Galego-Portugues de Química, Santiago de Compostela, Spain, 2019.
  8. Amélia M. Silva; Coutinho, T.E.; Adriano Morais; Tiago Monteiro; Diana Almeida; Carlos Martins-Gomes. "Eriodictyol and kaempferol: common plant flavonoids that exhibit anti-proliferative, anti-inflammatory and neuroprotective activity". Paper presented in XX EuroFoodChem Conference, Porto, Portugal, 2019.
  9. Ferreira, J.; Martins-Gomes, C.; Nunes, F. M.; Pacheco, M; Gaivão, I.; Silva, A. M.. "Assessing anti-oxidant, anti-proliferative and anti-inflammatory properties of red seaweeds (Grateloupia turuturu and Porphyra umbilicalis) coupled with a phenolic characterization.". Paper presented in XX EuroFoodChem Conference, Porto (Portugal), 2019.
  10. Carlos Martins-Gomes; Félix, Luís Manuel Lourenço; Meriem Taghouti; Fernando M. Nunes; Amélia M. Silva. "Major phytochemicals and bioactivities of extracts from Portuguese Thymus species". Paper presented in 4th Jornadas INTERACT, 2019.
  11. Carlos Martins-Gomes; Félix, Luís Manuel Lourenço; Fernando M. Nunes; Amélia M. Silva. "Thymus carnosus Boiss: uma espécie com potencial como alimento funcional". Paper presented in Ciência e Cidadania 2019, 2019.
  12. Coutinho, T.E.; Tiago Monteiro; Fernando M. Nunes; Amélia M. Silva. "Cucurbita ficifolia Bouché extracts promotes ROS scavenging activity and cell cycle arrest". Paper presented in International Conference on Medicinal Plants and Bioeconomy & the 1st Sino-CPLP Symposium on Natural Products and Biodiversity Resources, Macao, China, 2018.
  13. Irina Pereira; Aleksandra Zielinska; Ana Cláudia Santos; Izabela Nowak; Amélia M. Silva; Eliana B. Souto. "Optimization of linalool-loaded solid lipid nanoparticles (SLNs) by experimental factorial design". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery (SPLC-CRS), 2018.
  14. Carlos Martins-Gomes; Félix, Luís Manuel Lourenço; Fernando M. Nunes; Amélia M. Silva. "Thymus carnosus Boiss: an endangered species as a new potential functional food". Paper presented in International Conference on Medicinal Plants and Bioeconomy (ICMPB) & The 1st Sino-CPLP Symposium on Natural Products and Biodiversity Resources (SNPBR), 2018.
  15. Félix, Luís Manuel Lourenço; Tiago Coutinho; Carlos Martins-Gomes; Amélia M. Silva. "Flow cytometry study of cell cycle, apoptosis and oxidative stress of Thymus derived extracts in human colorectal cancer cell line (Caco-2)". Paper presented in International Conference on Medicinal Plants and Bioeconomy (ICMPB) & The 1st Sino-CPLP Symposium on Natural Products and Biodiversity Resources (SNPBR), 2018.
  16. Aleksandra Zielinska; Irina Pereira; Francisco J. B. Veiga; Amélia M. Silva; Ana Cláudia Santos; Izabela Nowak; Eliana B. Souto. "Optimization of a-pinene-loaded solid lipid nanoparticles (SLN) using experimental factorial design". Paper presented in Controlled Release Society Conference, 2017.
  17. Irina Pereira; Aleksandra Zielinska; Nuno R. Ferreira; Francisco J. B. Veiga; Amélia M. Silva; Ana Cláudia Santos; Izabela Nowak; Eliana B. Souto. "Accelerated stability evaluation of linalool-solid lipid nanoparticles (SLN) using a centrifugal sedimentation method (LUMiSizer®)". Paper presented in Controlled Release Society Conference, 2017.
  18. Irina Pereira; Aleksandra Zielinska; Francisco J. B. Veiga; Amélia M. Silva; Ana Cláudia Santos; Izabela Nowak; Eliana B. Souto. "Encapsulation of linalool in solid lipid nanoparticles". Paper presented in 6th European Young Engineers Conference, 2017.
  19. Aleksandra Zielinska; Irina Pereira; Agnieszka Feliczak-Guzik; Francisco J. B. Veiga; Amélia M. Silva; Ana Cláudia Santos; Izabela Nowak; Eliana B. Souto. "D-limonene-loaded solid lipid nanoparticles (SLN) as innovative delivery system for pharmacy and cosmetic industries". Paper presented in 6th European Young Engineers Conference, 2017.
  20. Aleksandra Zielinska; Irina Pereira; Ana Cláudia Santos; Amélia M. Silva; Izabela Nowak; Eliana B. Souto. "Ranibizumab - efficient remedy for neovascular age-related macular degeneration". Paper presented in 6th Berliner Chemie Symposium (BCS), 2017.
  21. Irina Pereira; Aleksandra Zielinska; Ana Cláudia Santos; Elena Sánchez-López; Amélia M. Silva; María Luisa García; Izabela Nowak; Eliana B. Souto. "Natural alkaloids: classical dopaminergic agonists formulated in new drug delivery systems". Paper presented in 6th Berliner Chemie Symposium (BCS), 2017.
  22. Inês Barejão; Félix, Luís Manuel Lourenço; Amélia M. Silva. "Estudo preliminar de extratos aquosos de Santolina Rosmarinifolia L. na viabilidade celular / Preliminary study of aqueous extracts of Santolina Rosmarinifolia L. on cell viability". Paper presented in Jornadas de Bioquímica UTAD, 2017.
  23. Tiago Coutinho; Félix, Luís Manuel Lourenço; Amélia M. Silva. "Efeito de um extrato hidro-etanólico de Santolina Rosmarinifolia L. na viabilidade celular e na atividade anti-inflamatória / Effect of a hydro-ethanolic extract of Santolina Rosmarinifolia L. on cell viability and anti-inflammatory activity". Paper presented in Jornadas de Bioquímica UTAD, 2017.
  24. Isabel Teixeira; Félix, Luís Manuel Lourenço; Amélia M. Silva. "Análise da viabilidade celular e da atividade anti-inflamatória de extratos de Thymus vulgaris cv. Fragrantissims em células RAW 264.7 / analysis of cell viability and anti-inflammatory activity of extracts of Thymus vulgaris cv. Fragrantissims in RAW 264.7 cells". Paper presented in Jornadas de Bioquímica UTAD, 2017.
Journal article
  1. Carlos Martins-Gomes; Fernando M. Nunes; Amélia M. Silva. "Natural Products as Dietary Agents for the Prevention and Mitigation of Oxidative Damage and Inflammation in the Intestinal Barrier". Antioxidants (2024): https://doi.org/10.3390/antiox13010065.
    10.3390/antiox13010065
  2. Beatriz N. Guedes; Faezeh Fathi; Amélia M. Silva; Antonello Santini; M. Beatriz P. P. Oliveira; Eliana B. Souto. "Biopharmaceutical applications of Opuntia ficus-indica: bibliometric map, bioactivities and extraction techniques". European Food Research and Technology (2023): https://doi.org/10.1007/s00217-023-04314-w.
    10.1007/s00217-023-04314-w
  3. Ana Abraão; Carlos Martins-Gomes; Raúl Domínguez-Perles; Ana Barros; Amélia M. Silva. "Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24108830.
    10.3390/ijms24108830
  4. Patrícia Gatinho; Cátia Salvador; Amélia M. Silva; Ana Teresa Caldeira. "Prokaryotic Communities from Pristine Cave Environments: Biotechnological Potential with Sustainable Production". Sustainability (2023): https://doi.org/10.3390/su15097471.
    10.3390/su15097471
  5. Ruth M. Galindo-Camacho; Isabel Haro; María J. Gómara; Marta Espina; Joel Fonseca; Carlos Martins-Gomes; Antoni Camins; et al. "Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel". International Journal of Pharmaceutics (2023): https://doi.org/10.1016/j.ijpharm.2023.122982.
    10.1016/j.ijpharm.2023.122982
  6. Carlos Martins-Gomes; Amélia M. Silva. "Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier". Journal of Xenobiotics (2023): https://doi.org/10.3390/jox13020014.
    10.3390/jox13020014
  7. David Franco Frazão; José Carlos Gonçalves; Amélia M. Silva; Fernanda Delgado; Delgado, F.; Franco Frazão, D.; Gonçalves, J.C.; Silva, A.M.. "Rockrose Land Management: Contribution of Periodic Harvesting to Increase Value and to Control Cistus ladanifer L. Shrublands". Forests (2023): https://doi.org/10.3390/f14030638.
    10.3390/f14030638
  8. Sandrine S. Ferreira; Pedro Silva; Amélia M. Silva; Fernando M. Nunes. "Effect of cultivar, maturation stage, and year on sugar and phenolic composition of elderberries". Journal of the Science of Food and Agriculture (2023): https://doi.org/10.1002/jsfa.12271.
    10.1002/jsfa.12271
  9. Carlos Martins-Gomes; Jan Steck; Judith Keller; Mirko Bunzel; João A. Santos; Fernando M. Nunes; Amélia M. Silva. "Phytochemical Composition and Antioxidant, Anti-Acetylcholinesterase, and Anti-a-Glucosidase Activity of Thymus carnosus Extracts: A Three-Year Study on the Impact of Annual Variation and Geographic Location". Antioxidants (2023): https://doi.org/10.3390/antiox12030668.
    10.3390/antiox12030668
  10. Ana Abraão; Manyou Yu; Irene Gouvinhas; Luís Ferreira; Amélia M. Silva; Raúl Domínguez-Perles; Ana Barros. "Prunus lusitanica L. Fruits: A Promising Underexploited Source of Nutrients with Potential Economic Value". Foods (2023): https://doi.org/10.3390/foods12050973.
    10.3390/foods12050973
  11. Carlos Martins-Gomes; Fernando M. Nunes; Amélia M. Silva. "Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24021691.
    10.3390/ijms24021691
  12. Souto, E.B.; Barbosa, C.I.; Baldim, I.; Campos, J.R.; Fernandes, A.R.; Mazzola, P.G.; Andreani, T.; et al. "Modified Drug Delivery Systems for Veterinary Use: Pharmaceutical Development and Applications". Current Bioactive Compounds 19 1 (2023): 69-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144295051&partnerID=MN8TOARS.
    10.2174/1573407218666220404110837
  13. Carlos Martins-Gomes; Jan Steck; Judith Keller; Mirko Bunzel; Fernando M. Nunes; Amélia M. Silva. "Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232315187.
    10.3390/ijms232315187
  14. Raquel de M. Barbosa; Amélia M. Silva; Classius F. da Silva; Juliana C. Cardoso; Patricia Severino; Lyghia M. A. Meirelles; Arnobio A. da Silva-Junior; et al. "Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use". Technologies (2022): https://doi.org/10.3390/technologies10050109.
    10.3390/technologies10050109
  15. Raquel da Ana; Joel Fonseca; Jacek Karczewski; Amélia M. Silva; Aleksandra Zielinska; Eliana B. Souto. "Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232012102.
    10.3390/ijms232012102
  16. Ruth M. Galindo-Camacho; Cristina Blanco Llamero; Raquel da Ana; Mayra A. Fuertes; Francisco Javier Señoráns; Amélia M Silva; María L. García; Souto, E.B.. "Therapeutic Approaches for Age-Related Macular Degeneration". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/19/11769.
    10.3390/ijms231911769
  17. Ana Santos Abraão; Nelson Fernandes; Amélia M. Silva; Raúl Domínguez-Perles; Ana Barros. "Prunus lusitanica L. Fruits as a Novel Source of Bioactive Compounds with Antioxidant Potential: Exploring the Unknown". Antioxidants (2022): https://doi.org/10.3390/antiox11091738.
    10.3390/antiox11091738
  18. Carlos Martins-Gomes; Tiago E. Coutinho; Tânia L. Silva; Tatiana Andreani; Amélia M. Silva. "Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays". Toxics (2022): https://doi.org/10.3390/toxics10080448.
    10.3390/toxics10080448
  19. Eliana B. Souto; Raquel da Ana; Vânia Vieira; Joana F. Fangueiro; João Dias-Ferreira; Amanda Cano; Aleksandra Zielinska; et al. "Non-melanoma skin cancers: physio-pathology and role of lipid delivery systems in new chemotherapeutic treatments". Neoplasia (2022): https://doi.org/10.1016/j.neo.2022.100810.
    10.1016/j.neo.2022.100810
  20. Amélia M. Silva; Carlos Martins-Gomes; Sandrine S. Ferreira; Eliana B. Souto; Tatiana Andreani. "Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23158107.
    10.3390/ijms23158107
  21. Amélia M. Silva; Carlos Martins-Gomes; Tânia L. Silva; Tiago E. Coutinho; Eliana B. Souto; Tatiana Andreani. "In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure". Toxics (2022): https://doi.org/10.3390/toxics10070378.
    10.3390/toxics10070378
  22. Tiago E. Coutinho; Eliana B. Souto; Amélia M. Silva. "Selected Flavonoids to Target Melanoma: A Perspective in Nanoengineering Delivery Systems". Bioengineering (2022): https://doi.org/10.3390/bioengineering9070290.
    10.3390/bioengineering9070290
  23. Aleksandra Zielinska; Amanda Cano; Tatiana Andreani; Carlos Martins-Gomes; Amélia M. Silva; Marlena Szalata; Ryszard Slomski; Eliana B. Souto. "Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol". International Journal of Molecular Sciences 23 11 (2022): 6165-6165. https://doi.org/10.3390/ijms23116165.
    10.3390/ijms23116165
  24. David F. Frazão; Carlos Martins-Gomes; Jan L. Steck; Judith Keller; Fernanda Delgado; José C. Gonçalves; Mirko Bunzel; et al. "Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities". Plants (2022): https://doi.org/10.3390/plants11111477.
    10.3390/plants11111477
  25. Souto, E.B.; Amanda Cano; Martins-Gomes, C.; Tiago E. Coutinho; Aleksandra Zielinska; Amélia M Silva. "Microemulsions and Nanoemulsions in Skin Drug Delivery". Bioengineering (2022): https://www.mdpi.com/2306-5354/9/4/158.
    10.3390/bioengineering9040158
  26. Ana Rita Fernandes; Aleksandra Zielinska; Elena Sanchez-Lopez; Tiago dos Santos; Maria Luisa Garcia; Amelia M. Silva; Jacek Karczewski; Eliana B. Souto. "Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options". International Journal of Molecular Sciences 23 5 (2022): 2592-2592. https://doi.org/10.3390/ijms23052592.
    10.3390/ijms23052592
  27. Carlos Martins-Gomes; Tânia L. Silva; Tatiana Andreani; Amélia M. Silva. "Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity". Journal of Xenobiotics (2022): https://doi.org/10.3390/jox12010003.
    10.3390/jox12010003
  28. Antonietti, S.; Silva, A.M.; Simões, C.; Almeida, D.; Félix, L.M.; Papetti, A.; Nunes, F.M.. "Chemical Composition and Potential Biological Activity of Melanoidins From Instant Soluble Coffee and Instant Soluble Barley: A Comparative Study". Frontiers in Nutrition 9 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85125263961&partnerID=MN8TOARS.
    10.3389/fnut.2022.825584
  29. Nazhand, A.; Durazzo, A.; Lucarini, M.; Silva, A.M.; Souto, S.B.; Severino, P.; Souto, E.B.; Santini, A.. "Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects". Current Bioactive Compounds 18 4 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85131155358&partnerID=MN8TOARS.
    10.2174/1573407217666210903113347
  30. Fernandes, A.R.; Vidal, L.B.; Sánchez-López, E.; dos Santos, T.; Granja, P.L.; Silva, A.M.; Garcia, M.L.; Souto, E.B.. "Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes". International Journal of Pharmaceutics 623 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85132880951&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2022.121938
  31. Fernandes, A.R.; dos Santos, T.; Granja, P.L.; Sanchez-Lopez, E.; Garcia, M.L.; Silva, A.M.; Souto, E.B.. "Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress". International Journal of Pharmaceutics 617 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85125233177&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2022.121615
  32. Ferreira, S.S.; Domingues, M.R.; Barros, C.; Santos, S.A.O.; Silvestre, A.J.D.; Silva, A.M.; Nunes, F.M.. "Major anthocyanins in elderberry effectively trap methylglyoxal and reduce cytotoxicity of methylglyoxal in HepG2 cell line". Food Chemistry: X 16 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140138726&partnerID=MN8TOARS.
    10.1016/j.fochx.2022.100468
  33. Ferreira, S.S.; Martins-Gomes, C.; Nunes, F.M.; Silva, A.M.. "Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity". Food Chemistry: X 15 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85138443140&partnerID=MN8TOARS.
    10.1016/j.fochx.2022.100437
  34. Souto, E.B.; Fangueiro, J.F.; Fernandes, A.R.; Cano, A.; Sanchez-Lopez, E.; Garcia, M.L.; Severino, P.; et al. "Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery". Heliyon 8 2 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85124485782&partnerID=MN8TOARS.
    10.1016/j.heliyon.2022.e08938
  35. Frazão, David; Silva, H.; Silva, A. M.; Gonçalves, J. C.; Mesquita, C.; Delgado, F.. Corresponding author: Frazão, David. "Labdanum resin from Cistus ladanifer.: evaluation of residual water vs. extraction yield". Actas Portuguesas de Horticultura 37 (2022): 73-84. https://aphorticultura.pt/wp-content/uploads/2022/09/Atas-Portuguesas-de-Horticultura-N%C2%BA37.pdf.
    Published
  36. Frazão, David; Barroca, C.; Silva, A. M.; Delgado, F.; Gonçalves, J. C.. Corresponding author: Gonçalves, J. C.. "Cistus ladanifer L. tissue culture from leaf and stem explants.". Journal of Biotechnology & Bioresearch 4 3 (2022): 544-550. https://repositorio.ipcb.pt/bitstream/10400.11/8199/1/JBB.000587micropropagaA_A_o.pdf..
    Published
  37. Aleksandra Zielinska; Piotr Eder; Lucas Rannier; Juliana C. Cardoso; Patrícia Severino; Amélia M. Silva; Eliana B. Souto. "Hydrogels for modified-release drug delivery systems". Current Pharmaceutical Design (2021): https://doi.org/10.2174/1381612828666211230114755.
    10.2174/1381612828666211230114755
  38. Ana R. Fernandes; Elena Sanchez-Lopez; Tiago dos Santos; Maria L. Garcia; Amelia M. Silva; Eliana B. Souto. "Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants". Materials (2021): https://doi.org/10.3390/ma14247541.
    10.3390/ma14247541
  39. Sara Cardoso; Classius F. da Silva; Patrícia Severino; Amélia M. Silva; Selma B. Souto; Aleksandra Zielinska; Jacek Karczewski; Eliana B. Souto. "Genotoxicity Assessment of Metal-Based Nanocomposites Applied in Drug Delivery". Materials 14 21 (2021): 6551-6551. https://doi.org/10.3390/ma14216551.
    10.3390/ma14216551
  40. Ana R. Fernandes; Elena Sanchez-Lopez; Antonello Santini; Tiago dos Santos; Maria L. Garcia; Amélia M. Silva; Eliana B. Souto. "Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterization". Nanomaterials 11 10 (2021): 2758-2758. https://doi.org/10.3390/nano11102758.
    10.3390/nano11102758
  41. Ana R. Fernandes; Tiago dos Santos; Pedro L. Granja; Elena Sanchez-Lopez; Antonello Santini; Maria L. Garcia; Amelia M. Silva; Eliana B. Souto. "DABCO-Customized Nanoemulsions: Characterization, Cell Viability and Genotoxicity in Retinal Pigmented Epithelium and Microglia Cells". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13101652.
    10.3390/pharmaceutics13101652
  42. Thiago R. Bjerk; Patricia Severino; Sona Jain; Conrado Marques; Amélia M. Silva; Tatiana Pashirova; Eliana B. Souto. "Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology". Bioengineering 8 8 (2021): 115-115. https://doi.org/10.3390/bioengineering8080115.
    10.3390/bioengineering8080115
  43. "Red seaweeds strengthening the nexus between nutrition and health: phytochemical characterization and bioactive properties of Grateloupia turuturu and Porphyra umbilicalis extracts". Journal of Applied Phycology (2021): http://dx.doi.org/10.1007/s10811-021-02529-6.
    10.1007/s10811-021-02529-6
  44. Silva, A.M.; Félix, L.M.; Teixeira, I.; Martins-Gomes, C.; Schäfer, J.; Souto, E.B.; Santos, D.J.; Bunzel, M.; Nunes, F.M.. "Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits". Food Chemistry: X 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85124095808&partnerID=MN8TOARS.
    10.1016/j.fochx.2021.100171
  45. Durazzo, A.; Nazhand, A.; Lucarini, M.; Silva, A.M.; Souto, S.B.; Guerra, F.; Severino, P.; et al. "Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role". Rendiconti Lincei 32 3 (2021): 625-642. http://www.scopus.com/inward/record.url?eid=2-s2.0-85108237594&partnerID=MN8TOARS.
    10.1007/s12210-021-01003-2
  46. Tatiana Andreani; Verónica Nogueira; Ana Gavina; Saul Fernandes; José Luís Rodrigues; Vera V. Pinto; Maria José Ferreira; et al. "Ecotoxicity to Freshwater Organisms and Cytotoxicity of Nanomaterials: Are We Generating Sufficient Data for Their Risk Assessment?". Nanomaterials (2020): https://doi.org/10.3390/nano11010066.
    10.3390/nano11010066
  47. Aleksandra Zielinska; Konrad Kubasiewicz; Krzysztof Wójcicki; Amélia M. Silva; Fernando M. Nunes; Marlena Szalata; Ryszard Slomski; Piotr Eder; Eliana B. Souto. "Two- and Three-Dimensional Spectrofluorimetric Qualitative Analysis of Selected Vegetable Oils for Biomedical Applications". Molecules 25 23 (2020): 5608-5608. https://doi.org/10.3390/molecules25235608.
    10.3390/molecules25235608
  48. Meriem Taghouti; Carlos Martins-Gomes; Luís M. Félix; Judith Schäfer; João A. Santos; Mirko Bunzel; Fernando M. Nunes; Amélia M. Silva. "Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species". Food Chemistry 331 (2020): 127362-127362. https://doi.org/10.1016/j.foodchem.2020.127362.
    10.1016/j.foodchem.2020.127362
  49. Carla Leal; Irene Gouvinhas; Rafaela A. Santos; Eduardo Rosa; Amélia M. Silva; Maria José Saavedra; Ana I.R.N.A. Barros. "Potential application of grape (Vitis vinifera L.) stem extracts in the cosmetic and pharmaceutical industries: Valorization of a by-product". Industrial Crops and Products 154 (2020): 112675-112675. https://doi.org/10.1016/j.indcrop.2020.112675.
    10.1016/j.indcrop.2020.112675
  50. Aleksandra Zielinska; Filipa Carreiró; Ana M. Oliveira; Andreia Neves; Bárbara Pires; D. Nagasamy Venkatesh; Alessandra Durazzo; et al. "Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology". Molecules 25 16 (2020): 3731-3731. https://doi.org/10.3390/molecules25163731.
    10.3390/molecules25163731
  51. Eliana B. Souto; Alessandra Durazzo; Amirhossein Nazhand; Massimo Lucarini; Massimo Zaccardelli; Selma B. Souto; Amelia M. Silva; et al. "Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives". Forests 11 7 (2020): 761-761. https://doi.org/10.3390/f11070761.
    10.3390/f11070761
  52. Sandrine S. Ferreira; Amélia M. Silva; Fernando M. Nunes. "Sambucus nigra L. Fruits and Flowers: Chemical Composition and Related Bioactivities". Food Reviews International (2020): 1-29. https://doi.org/10.1080/87559129.2020.1788578.
    10.1080/87559129.2020.1788578
  53. Massimo Zaccardelli; Catello Pane; Michele Caputo; Alessandra Durazzo; Massimo Lucarini; Amélia M. Silva; Patrícia Severino; et al. "Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria". Forests 11 6 (2020): 704-704. https://doi.org/10.3390/f11060704.
    10.3390/f11060704
  54. Amélia M. Silva; Carlos Martins-Gomes; Eliana B. Souto; Judith Schäfer; João A. Santos; Mirko Bunzel; Fernando M. Nunes. "Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities". Antioxidants 9 6 (2020): 482-482. https://doi.org/10.3390/antiox9060482.
    10.3390/antiox9060482
  55. Eurico Lima; Renato Boto; Diana Ferreira; José Ramiro Afonso Fernandes; Paulo Almeida; L.F. Vieira Ferreira; Souto, E.B.; Amélia M Silva; Lucinda V. Reis. "Quinoline- and Benzoselenazole-Derived Unsymmetrical Squaraine Cyanine Dyes: Design, Synthesis, Photophysicochemical Features and Light-Triggerable Antiproliferative Effects against Breast Cancer Cell Lines". Materials (2020): https://www.mdpi.com/1996-1944/13/11/2646.
    10.3390/ma13112646
  56. Amirhossein Nazhand; Massimo Lucarini; Alessandra Durazzo; Massimo Zaccardelli; Santo Cristarella; Selma B. Souto; Amélia M. Silva; et al. "Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties". Forests 11 5 (2020): 564-564. https://doi.org/10.3390/f11050564.
    10.3390/f11050564
  57. Tiago D. Martins; Eurico Lima; Renato E. Boto; Diana Ferreira; José R. Fernandes; Paulo Almeida; Luis F. V. Ferreira; Amélia M. Silva; Lucinda V. Reis. "Red and Near-Infrared Absorbing Dicyanomethylene Squaraine Cyanine Dyes: Photophysicochemical Properties and Anti-Tumor Photosensitizing Effects". Materials 13 9 (2020): 2083-2083. https://doi.org/10.3390/ma13092083.
    10.3390/ma13092083
  58. Alessandra Durazzo; Massimo Lucarini; Amirhossein Nazhand; Selma B. Souto; Amélia M. Silva; Patrícia Severino; Eliana B. Souto; Antonello Santini. "The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements". Molecules 25 9 (2020): 2127-2127. https://doi.org/10.3390/molecules25092127.
    10.3390/molecules25092127
  59. Eliana B. Souto; Joana R. Campos; Raquel Da Ana; Carlos Martins-Gomes; Amélia M. Silva; Selma B. Souto; Massimo Lucarini; Alessandra Durazzo; Antonello Santini. "Ocular Cell Lines and Genotoxicity Assessment". International Journal of Environmental Research and Public Health 17 6 (2020): 2046-2046. https://doi.org/10.3390/ijerph17062046.
    10.3390/ijerph17062046
  60. Eliana B. Souto; Ana Rita Fernandes; Carlos Martins-Gomes; Tiago E. Coutinho; Alessandra Durazzo; Massimo Lucarini; Selma B. Souto; Amélia M. Silva; Antonello Santini. "Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals". Applied Sciences 10 5 (2020): 1594-1594. https://doi.org/10.3390/app10051594.
    10.3390/app10051594
  61. Eliana B. Souto; Aleksandra Zielinska; Selma B. Souto; Alessandra Durazzo; Massimo Lucarini; Antonello Santini; Amélia M. Silva; et al. "(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line". International Journal of Molecular Sciences 21 4 (2020): 1449-1449. https://doi.org/10.3390/ijms21041449.
    10.3390/ijms21041449
  62. Elena Sánchez López; Ana Laura Lopez Machado; Lorena Bonilla Vidal; Roberto Gonzalez Pizarro; Amelia D Silva; Eliana B. Souto. "Lipid nanoparticles as carriers for the treatment of neurodegeneration associated with Alzheimer’s disease and glaucoma: present and future challenges". Current Pharmaceutical Design (2020): https://doi.org/10.2174/1381612826666200218101231.
    10.2174/1381612826666200218101231
  63. Raquel Vieira; Patricia Severino; Luciana A. Nalone; Selma B. Souto; Amélia M. Silva; Massimo Lucarini; Alessandra Durazzo; Antonello Santini; Eliana B. Souto. "Sucupira Oil-Loaded Nanostructured Lipid Carriers (NLC): Lipid Screening, Factorial Design, Release Profile, and Cytotoxicity". Molecules 25 3 (2020): 685-685. https://doi.org/10.3390/molecules25030685.
    10.3390/molecules25030685
  64. Souto, E.B.; Selma B. Souto; Aleksandra Zielinska; Alessandra Durazzo; Massimo Lucarini; Antonello SANTINI; Olaf K. Horbanczuk; et al. "Perillaldehyde 1,2-epoxide Loaded SLN-Tailored mAb: Production, Physicochemical Characterization and In Vitro Cytotoxicity Profile in MCF-7 Cell Lines". Pharmaceutics (2020): https://www.mdpi.com/1999-4923/12/2/161.
    10.3390/pharmaceutics12020161
  65. Selma B. Souto; Joana R. Campos; Joana F. Fangueiro; Amélia M. Silva; Nicola Cicero; Massimo Lucarini; Alessandra Durazzo; Antonello Santini; Eliana B. Souto. "Multiple Cell Signalling Pathways of Human Proinsulin C-Peptide in Vasculopathy Protection". International Journal of Molecular Sciences 21 2 (2020): 645-645. https://doi.org/10.3390/ijms21020645.
    10.3390/ijms21020645
  66. Ferreira, S.S.; Silva, P.; Silva, A.M.; Nunes, F.M.. "Effect of harvesting year and elderberry cultivar on the chemical composition and potential bioactivity: A three-year study". Food Chemistry 302 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070884280&partnerID=MN8TOARS.
    10.1016/j.foodchem.2019.125366
  67. de Jesus, D.F.; Orime, K.; Kaminska, D.; Kimura, T.; Basile, G.; Wang, C.-H.; Haertle, L.; et al. "Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice". Journal of Clinical Investigation 130 5 (2020): 2391-2404. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084231270&partnerID=MN8TOARS.
    10.1172/JCI127502
  68. Souto, E.B.; Campos, J.R.; Da Ana, R.; Fangueiro, J.F.; Martins-Gomes, C.; Durazzo, A.; Lucarini, M.; et al. "Diabetic retinopathy and ocular melanoma: How far we are?". Applied Sciences (Switzerland) 10 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084677122&partnerID=MN8TOARS.
    10.3390/APP10082777
  69. Sánchez-López, E.; Gomes, D.; Esteruelas, G.; Bonilla, L.; Lopez-Machado, A.L.; Galindo, R.; Cano, A.; et al. "Metal-based nanoparticles as antimicrobial agents: An overview". Nanomaterials 10 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079557582&partnerID=MN8TOARS.
    10.3390/nano10020292
  70. Andreani, T.; Dias-Ferreira, J.; Fangueiro, J.F.; Souza, A.L.R.; Kiill, C.P.; Gremião, M.P.D.; García, M.L.; Silva, A.M.; Souto, E.B.. "Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection". Heliyon 6 5 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084091815&partnerID=MN8TOARS.
    10.1016/j.heliyon.2020.e03831
  71. Fernandes, T.C.D.; Lima, E.; Boto, R.E.; Ferreira, D.; Fernandes, J.R.; Almeida, P.; Ferreira, L.F.V.; Silva, A.M.; Reis, L.V.. "In vitro phototherapeutic effects of indolenine-based mono- and dithiosquaraine cyanine dyes against Caco-2 and HepG2¿human cancer cell lines". Photodiagnosis and Photodynamic Therapy 31 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085948160&partnerID=MN8TOARS.
    10.1016/j.pdpdt.2020.101844
  72. Souto, E.B.; da Ana, R.; Souto, S.B.; Zielinska, A.; Marques, C.; Andrade, L.N.; Horbanczuk, O.K.; et al. "In vitro characterization, modelling, and antioxidant properties of polyphenon-60 from green tea in eudragit s100-2 chitosan microspheres". Nutrients 12 4 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083041617&partnerID=MN8TOARS.
    10.3390/nu12040967
  73. Meriem Taghouti; Carlos Martins-Gomes; Judith Schäfer; João A. Santos; Mirko Bunzel; Fernando M. Nunes; Amélia M Silva. "Chemical Characterization and Bioactivity of Extracts from Thymus mastichina: A Thymus with a Distinct Salvianolic Acid Composition". Antioxidants 9 1 (2019): 34-34. https://doi.org/10.3390/antiox9010034.
    10.3390/antiox9010034
  74. Sofia Friães; Eurico Lima; Renato E. Boto; Diana Ferreira; José R. Fernandes; Luis F. V. Ferreira; Amélia M. Silva; Lucinda V. Reis. "Photophysicochemical Properties and In Vitro Phototherapeutic Effects of Iodoquinoline- and Benzothiazole-Derived Unsymmetrical Squaraine Cyanine Dyes". Applied Sciences (2019): https://doi.org/10.3390/app9245414.
    10.3390/app9245414
  75. Ana Luiza R. de Souza; Mariana Fonseca; Leonardo Miziara Barboza Ferreira; Suzy S.S. Kurokawa; Charlene P. Kiill; Natália N. Ferreira; Alexandre dos Santos Pyrrho; et al. "Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness". Colloids and Surfaces B: Biointerfaces 184 (2019): 110523-110523. https://doi.org/10.1016/j.colsurfb.2019.110523.
    10.1016/j.colsurfb.2019.110523
  76. Amélia M. Silva; Sandra C. Silva; Jorge P. Soares; Carlos Martins-Gomes; João Paulo Teixeira; Fernanda Leal; Isabel Gaivão. "Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxidative DNA Damage". Plants (2019): https://doi.org/10.3390/plants8120556.
    10.3390/plants8120556
  77. Amélia M. Silva; Carlos Martins-Gomes; Joana F. Fangueiro; Tatiana Andreani; Eliana B. Souto. "Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines". Pharmaceutical Development and Technology (2019): 1-7. https://doi.org/10.1080/10837450.2019.1658774.
    10.1080/10837450.2019.1658774
  78. Eliana B. Souto; Selma B. Souto; Joana R. Campos; Patricia Severino; Tatiana N. Pashirova; Lucia Y. Zakharova; Amélia M. Silva; et al. "Nanoparticle Delivery Systems in the Treatment of Diabetes Complications". Molecules 24 23 (2019): 4209-4209. https://doi.org/10.3390/molecules24234209.
    10.3390/molecules24234209
  79. Eliana B. Souto; João Dias-Ferreira; Jéssica Oliveira; Elena Sanchez-Lopez; Ana Lopez-Machado; Marta Espina; Maria L. Garcia; et al. "Trends in Atopic Dermatitis—From Standard Pharmacotherapy to Novel Drug Delivery Systems". International Journal of Molecular Sciences 20 22 (2019): 5659-5659. https://doi.org/10.3390/ijms20225659.
    10.3390/ijms20225659
  80. Lucia Ya. Zakharova; Tatiana Pashirova; Slavomira Doktorovova; Ana R. Fernandes; Elena Sánchez López; Amélia M Silva; Selma B. Souto; Souto, E.B.. "Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/22/5534.
    10.3390/ijms20225534
  81. Eliana B. Souto; Slavomira Doktorovova; Aleksandra Zielinska; Amélia M. Silva. "Key production parameters for the development of solid lipid nanoparticles by high shear homogenization". Pharmaceutical Development and Technology (2019): 1-5. https://doi.org/10.1080/10837450.2019.1647235.
    10.1080/10837450.2019.1647235
  82. Amélia Silva; Carlos Martins-Gomes; Tiago Coutinho; Joana Fangueiro; Elena Sanchez-Lopez; Tatiana Pashirova; Tatiana Andreani; Eliana Souto. "Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLNs)". Applied Sciences 9 20 (2019): 4438-4438. https://doi.org/10.3390/app9204438.
    10.3390/app9204438
  83. E. B. Souto; J. C. Campos; S. C. Filho; M. C. Teixeira; C. Martins-Gomes; A. Zielinska; C. Carbone; A. M. Silva. "3D printing in the design of pharmaceutical dosage forms". Pharmaceutical Development and Technology (2019): 1-10. https://doi.org/10.1080/10837450.2019.1630426.
    10.1080/10837450.2019.1630426
  84. Aleksandra Zielinska; Nuno R. Ferreira; Alessandra Durazzo; Massimo Lucarini; Nicola Cicero; Soukaina El Mamouni; Amélia M. Silva; et al. "Development and Optimization of Alpha-Pinene-Loaded Solid Lipid Nanoparticles (SLN) Using Experimental Factorial Design and Dispersion Analysis". Molecules 24 15 (2019): 2683-2683. https://doi.org/10.3390/molecules24152683.
    10.3390/molecules24152683
  85. Amélia M. Silva; Helen L. Alvarado; Guadalupe Abrego; Carlos Martins-Gomes; Maria L. Garduño-Ramirez; María L. García; Ana C. Calpena; Eliana B. Souto. "In Vitro Cytotoxicity of Oleanolic/Ursolic Acids-Loaded in PLGA Nanoparticles in Different Cell Lines". Pharmaceutics (2019): https://doi.org/10.3390/pharmaceutics11080362.
    10.3390/pharmaceutics11080362
  86. Claudia Carbone; Maria do Céu Teixeira; Maria do Céu Sousa; Carlos Martins-Gomes; Amelia M. Silva; Eliana Maria Barbosa Souto; Teresa Musumeci. "Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of Candida Skin Infections". Pharmaceutics 11 5 (2019): 231-231. https://doi.org/10.3390/pharmaceutics11050231.
    10.3390/pharmaceutics11050231
  87. Campos, J.R.; Fernandes, A.R.; Sousa, R.; Fangueiro, J.F.; Boonme, P.; Garcia, M.L.; Silva, A.M.; Naveros, B.C.; Souto, E.B.. "Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line". Pharmaceutical Development and Technology 24 5 (2019): 616-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059552534&partnerID=MN8TOARS.
    10.1080/10837450.2018.1549075
  88. Andreani, T.; Fangueiro, J.F.; Severino, P.; de Souza, A.L.R.; Martins-Gomes, C.; Fernandes, P.M.V.; Calpena, A.C.; et al. "The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery". Nanomaterials 9 8 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070412332&partnerID=MN8TOARS.
    10.3390/nano9081081
  89. Souto, E.B.; Dias-Ferreira, J.; Craveiro, S.A.; Severino, P.; Sanchez-Lopez, E.; Garcia, M.L.; Silva, A.M.; Souto, S.B.; Mahant, S.. "Therapeutic interventions for countering leishmaniasis and chagas’s disease: From traditional sources to nanotechnological systems". Pathogens 8 3 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070803531&partnerID=MN8TOARS.
    10.3390/pathogens8030119
  90. Souto, E.B.; Zielinska, A.; Luis, M.; Carbone, C.; Martins-Gomes, C.; Souto, S.B.; Silva, A.M.. "Uveal melanoma: physiopathology and new in situ-specific therapies". Cancer Chemotherapy and Pharmacology 84 1 (2019): 15-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065741902&partnerID=MN8TOARS.
    10.1007/s00280-019-03860-z
  91. Souto, E.B.; Doktorovova, S.; Campos, J.R.; Martins-Lopes, P.; Silva, A.M.. "Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells". European Journal of Pharmaceutical Sciences 128 (2019): 27-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059335683&partnerID=MN8TOARS.
    10.1016/j.ejps.2018.11.022
  92. Martins-Gomes, C.; Souto, E.B.; Cosme, F.; Nunes, F.M.; Silva, A.M.. "Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis". Journal of Functional Foods 54 (2019): 128-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059936808&partnerID=MN8TOARS.
    10.1016/j.jff.2019.01.010
  93. Souto, E.B.; Lima, B.; Campos, J.R.; Martins-Gomes, C.; Souto, S.B.; Silva, A.M.. "Myasthenia gravis: State of the art and new therapeutic strategies". Journal of Neuroimmunology 337 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073987816&partnerID=MN8TOARS.
    10.1016/j.jneuroim.2019.577080
  94. Vieira, R.; Souto, S.B.; Sánchez-López, E.; Machado, A.L.; Severino, P.; Jose, S.; Santini, A.; et al. "Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—strategies for in vivo administration: Part-II". Journal of Clinical Medicine 8 9 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074006501&partnerID=MN8TOARS.
    10.3390/jcm8091332
  95. Vieira, R.; Souto, S.B.; Sánchez-López, E.; Machado, A.L.; Severino, P.; Jose, S.; Santini, A.; et al. "Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—review of classical and new compounds: Part-i". Pharmaceuticals 12 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074027524&partnerID=MN8TOARS.
    10.3390/ph12040152
  96. Ferreira, Sandrine S.; SILVA, Amélia M.; Nunes, Fernando M.. "Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds". Industrial Crops and Products 111 2018 (2018): 141-148.
    Published • 10.1016/j.indcrop.2017.10.009
  97. Silva-Abreu, Marcelle; Calpena, Ana Cristina; Espina, Marta; Silva, Amelia M.; Gimeno, Alvaro; Egea, María Antonia; García, María Luisa. "Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders". Pharmaceutical Research 35 1 (2018): 1-14.
    Published • 10.1007/s11095-017-2319-8
  98. Sánchez-López, Elena; Egea, Maria Antonia; Davis, Benjamin Michael; Guo, Li; Espina, Marta; Silva, Amelia Maria; Calpena, Ana Cristina; et al. "Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma". Small 14 2 (2018): 1701808-1701808.
    Published • 10.1002/smll.201701808
  99. Martins-Gomes, Carlos; Taghouti, Meriem; Schäfer, Judith; Bunzel, Mirko; SILVA, Amélia M.; Nunes, Fernando M.. "Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.". Journal of Functional Foods 43 2018 (2018): 154-164.
    Published • 10.1016/j.jff.2018.02.012
  100. Sánchez-López, Elena; Ettcheto, Miren; Egea, Maria Antonia; Espina, Marta; Cano, Amanda; Calpena, Ana Cristina; Camins, Antoni; et al. "Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization". Journal of Nanobiotechnology 16 1 (2018): 1-16.
    Published • 10.1186/s12951-018-0356-z
  101. Carbone, C.; Martins-Gomes, C.; Pepe, V.; Silva, A.M.; Musumeci, T.; Puglisi, G.; Furneri, P.M.; Souto, E.B.. "Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy". Colloids and Surfaces B: Biointerfaces 167 2018 (2018): 337-344.
    Published • 10.1016/j.colsurfb.2018.04.031
  102. Sario, Sara; SILVA, Amélia M.; Gaivão, Isabel. "Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts)". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 831 2018 (2018): 19-23.
    Published • 10.1016/j.mrgentox.2018.05.001
  103. Taghouti, Meriem; Martins-Gomes, Carlos; Schäfer, Judith; Félix, Luis M.; Santos, João A.; Bunzel, Mirko; Nunes, Fernando M.; SILVA, Amélia M.. "Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds". Food & Function 9 7 (2018): 3617-3629.
    Published • 10.1039/C8FO00456K
  104. Carbone, C.; Martins-Gomes, C.; Caddeo, C.; Silva, A.M.; Musumeci, T.; Pignatello, R.; Puglisi, G.; Souto, E.B.. "Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles". International Journal of Pharmaceutics 548 1 (2018): 217-226.
    Published • 10.1016/j.ijpharm.2018.06.064
  105. Pereira, Irina; Zielinska, Aleksandra; Ferreira, Nuno R.; SILVA, Amélia M.; Souto, Eliana B.. "Optimization of linalool-loaded solid lipid nanoparticles using experimental factorial design and long-term stability studies with a new centrifugal sedimentation method". International Journal of Pharmaceutics 549 1-2 (2018): 261-270.
    Published • 10.1016/j.ijpharm.2018.07.068
  106. Pereira, Irina; Severino, Patrícia; Santos, Ana C.; SILVA, Amélia M.; Souto, Eliana B.. "Linalool bioactive properties and potential applicability in drug delivery systems". Colloids and Surfaces B: Biointerfaces 171 2018 (2018): 566-578.
    Published • 10.1016/j.colsurfb.2018.08.001
  107. Zielinska, Aleksandra; Martins-Gomes, Carlos; Ferreira, Nuno R.; SILVA, Amélia M.; Nowak, Izabela; Souto, Eliana B.. "Anti-inflammatory and anti-cancer activity of citral: Optimization of citral-loaded solid lipid nanoparticles (SLN) using experimental factorial design and LUMiSizer®". International Journal of Pharmaceutics 553 1-2 (2018): 428-440.
    Published • 10.1016/j.ijpharm.2018.10.065
  108. Taghouti, M.; Martins-Gomes, C.; Schäfer, J.; Félix, L.M.; Santos, J.A.; Bunzel, M.; Nunes, F.M.; Amélia M. Silva. "Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds". Food and Function 9 7 (2018): 3617-3629. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050569468&partnerID=MN8TOARS.
    Published • 10.1039/c8fo00456k
  109. Sampaio, A.C.; Mendes, R.J.; Castro, P.G.; Silva, A.M.. "Solid lipid nanoparticles affect microbial colonization and enzymatic activity throughout the decomposition of alder leaves in freshwater microcosms". Ecotoxicology and Environmental Safety 135 - (2017): 375-380.
    Published • 10.1016/j.ecoenv.2016.10.020
  110. Kiilll, Charlene Priscila; Barud, Hernane da Silva; Santagneli, Sílvia Helena; Ribeiro, Sidney José Lima; SILVA, Amélia M.; Tercjak, Agnieszka; Gutierrez, Junkal; Pironi, Andressa Maria; Gremião, Maria Palmira Daflon. "Synthesis and factorial design applied to a novel chitosan/sodium polyphosphate nanoparticles via ionotropic gelation as an RGD delivery system". Carbohydrate Polymers 157 - (2017): 1695-1702.
    Published • 10.1016/j.carbpol.2016.11.053
  111. Teixeira, M.C.; Severino, P.; Andreani, T.; Boonme, P.; Santini, A.; Silva, A.M.; Souto, E.B.. "d -alpha-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity". Saudi Pharmaceutical Journal 25 2 (2017): 231-235.
    Published • 10.1016/j.jsps.2016.06.004
  112. Friães, Sofia; SILVA, Amélia M.; Boto, Renato E.; Ferreira, Diana; Fernandes, José R.; Souto, Eliana B.; Almeida, Paulo; Ferreira, Luis F. Vieira; Reis, Lucinda V.. "Synthesis, spectroscopic characterization and biological evaluation of unsymmetrical aminosquarylium cyanine dyes". Bioorganic & Medicinal Chemistry 25 14 (2017): 3803-3814.
    Published • 10.1016/j.bmc.2017.05.022
  113. Queiroz, Marcelo; Oppolzer, David; Gouvinhas, Irene; SILVA, Amélia M.; Barros, Ana I.R.N.A.; Domínguez-Perles, Raúl. "New grape stems' isolated phenolic compounds modulate reactive oxygen species, glutathione, and lipid peroxidation in vitro : Combined formulations with vitamins C and E". Fitoterapia 120 2017 (2017): 146-157.
    Published • 10.1016/j.fitote.2017.06.010
  114. Sousa, C.; Pereira, I.; Santos, A.C.; Carbone, C.; Kova¿?evic, A.B.; Silva, A.M.; Souto, E.B.. "Targeting dendritic cells for the treatment of autoimmune disorders". Colloids and Surfaces B: Biointerfaces 158 2017 (2017): 237-248.
    Published • 10.1016/j.colsurfb.2017.06.050
  115. Fernandes, A.R.; Ferreira, N.R.; Fangueiro, J.F.; Santos, A.C.; Veiga, F.J.; Cabral, C.; Silva, A.M.; Souto, E.B.. "Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs". Saudi Pharmaceutical Journal 25 8 (2017): 1117-1124.
    Published • 10.1016/j.jsps.2017.07.004
  116. Doktorovova, Slavomira; Souto, Eliana B.; SILVA, Amélia M.. "Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines". Pharmaceutical Development and Technology 23 1 (2017): 96-105.
    Published • 10.1080/10837450.2017.1384491
  117. Andreani, T.; Nogueira, V.; Pinto, V.V.; Ferreira, M.J.; Rasteiro, M.G.; Silva, A.M.; Pereira, R.; Pereira, C.M.. "Influence of the stabilizers on the toxicity of metallic nanomaterials in aquatic organisms and human cell lines". Science of the Total Environment 607-608 (2017): 1264-1277. http://www.scopus.com/inward/record.url?eid=2-s2.0-85024364000&partnerID=MN8TOARS.
    10.1016/j.scitotenv.2017.07.098
  118. Cañadas, Cristina; Alvarado, Helen; Calpena, Ana C.; SILVA, Amélia M.; Souto, Eliana B.; García, Maria L.; Abrego, Guadalupe. "In vitro, ex vivo and in vivo characterization of PLGA nanoparticles loading pranoprofen for ocular administration". International Journal of Pharmaceutics 511 2 (2016): 719-727.
    Published • 10.1016/j.ijpharm.2016.07.055
  119. Domínguez-Perles, Raúl; Guedes, Ana; Queiroz, Marcelo; SILVA, Amélia M.; Barros, Ana I.R.N.A.. "Oxidative stress prevention and anti-apoptosis activity of grape (Vitis vinifera L.) stems in human keratinocytes". Food Research International 87 - (2016): 92-102.
    Published • 10.1016/j.foodres.2016.06.030
  120. Boonme, Prapaporn; Kaewbanjong, Jarika; Amnuaikit, Thanaporn; Andreani, Tatiana; Silva, Amélia; Souto, Eliana. "Microemulsion and Microemulsion-Based Gels for Topical Antifungal Therapy with Phytochemicals". Current Pharmaceutical Design 22 27 (2016): 4257-4263.
    Published • 10.2174/1381612822666160603015436
  121. Fujimura, Andressa T.; Martinez, Renata M.; Pinho-Ribeiro, Felipe A.; Lopes Dias da Silva, Amélia M.; Baracat, Marcela M.; Georgetti, Sandra R.; Verri, Waldiceu A.; Chorilli, Marlus; Casagrande, Rubia. "Resveratrol-Loaded Liquid-Crystalline System Inhibits UVB-Induced Skin Inflammation and Oxidative Stress in Mice". Journal of Natural Products 79 5 (2016): 1329-1338.
    Published • 10.1021/acs.jnatprod.5b01132
  122. Sánchez-López, E.; Egea, M.A.; Cano, A.; Espina, M.; Calpena, A.C.; Ettcheto, M.; Camins, A.; et al. "PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen—in vitro, ex vivo and in vivo characterization". Colloids and Surfaces B: Biointerfaces 145 - (2016): 241-250.
    Published • 10.1016/j.colsurfb.2016.04.054
  123. Santos, Stefanie; SILVA, Amélia M.; Matos, Manuela; Monteiro, Sandra M.; ¿?lvaro, Ana R.. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53". Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 185186 - (2016): 138-146.
    Published • 10.1016/j.cbpc.2016.03.010
  124. Fangueiro, Joana F.; Calpena, Ana C.; Clares, Beatriz; Andreani, Tatiana; Egea, Maria A.; Veiga, Francisco J.; Garcia, Maria L.; SILVA, Amélia M.; Souto, Eliana B.. "Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo, in vitro and ex vivo studies". International Journal of Pharmaceutics 502 1-2 (2016): 161-169.
    Published • 10.1016/j.ijpharm.2016.02.039
  125. Fangueiro, Joana; Veiga, Francisco; Silva, Amelia; Souto, Eliana; Fangueiro, J.F.; Veiga, F.; Silva, A.M.; Souto, E.B.. "Ocular Drug Delivery - New Strategies for Targeting Anterior and Posterior Segments of the Eye". Current Pharmaceutical Design 22 9 (2016): 1135-1146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959502618&partnerID=MN8TOARS.
    Published • 10.2174/1381612822666151216145900
  126. Severino, Patrícia; Szymanski, Marcelo; Favaro, Marianna; Azzoni, Adriano R.; Chaud, Marco V.; Santana, Maria Helena A.; SILVA, Amélia M.; Souto, Eliana B.. "Development and characterization of a cationic lipid nanocarrier as non-viral vector for gene therapy". European Journal of Pharmaceutical Sciences 66 - (2015): 78-82.
    Published • 10.1016/j.ejps.2014.09.021
  127. Soares, Jorge Pinto; Silva, Amélia Maria; Fonseca, Sandra; Oliveira, Maria Manuel; Peixoto, Francisco; Gaivão, Isabel; Mota, Maria Paula. "How can age and lifestyle variables affect DNA damage, repair capacity and endogenous biomarkers of oxidative stress?". Experimental Gerontology 62 - (2015): 45-52.
    Published • 10.1016/j.exger.2015.01.001
  128. Andreani, Tatiana; SILVA, Amélia M.; Souto, Eliana B.. "Silica based-matrices: State of the art and new perspectives for therapeutic drug delivery". Biotechnology and Applied Biochemistry n - (2015): n/a-n/a.
    Published • 10.1002/bab.1322
  129. Fangueiro, Joana F.; SILVA, Amélia M.; Garcia, Maria L.; Souto, Eliana B.. "Current nanotechnology approaches for the treatment and management of diabetic retinopathy". European Journal of Pharmaceutics and Biopharmaceutics - (2015): na-na.
    Published • 10.1016/j.ejpb.2014.12.023
  130. Vazzana, M.; Andreani, T.; Fangueiro, J.; Faggio, C.; Silva, C.; Santini, A.; Garcia, M.L.; Silva, A.M.; Souto, E.B.. "Tramadol hydrochloride: Pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems". Biomedicine & Pharmacotherapy 70 2015 (2015): 234-238.
    Published • 10.1016/j.biopha.2015.01.022
  131. Andreani, Tatiana; Miziara, Leonardo; Lorenzón, Esteban N.; de Souza, Ana Luiza R.; Kiill, Charlene P.; Fangueiro, Joana F.; Garcia, Maria L.; et al. "Effect of mucoadhesive polymers on the in vitro performance of insulin-loaded silica nanoparticles: Interactions with mucin and biomembrane models". European Journal of Pharmaceutics and Biopharmaceutics 93 - (2015): 118-126.
    Published • 10.1016/j.ejpb.2015.03.027
  132. Andreani, Tatiana; Kiill, Charlene P.; de Souza, Ana Luiza R.; Fangueiro, Joana F.; Doktorovová, Slavomira; Garcia, Maria L.; Gramião, Maria Palmira D.; SILVA, Amélia M.; Souto, Eliana B.. "Effect of cryoprotectants on the reconstitution of silica nanoparticles produced by sol–gel technology". Journal of Thermal Analysis and Calorimetry 120 1 (2015): 1001-1007.
    Published • 10.1007/s10973-014-4275-4
  133. Soares, Jorge Pinto; SILVA, Amélia M.; Oliveira, Maria Manuel; Peixoto, Francisco; Gaivão, Isabel; Mota, Maria Paula. "Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes". AGE 37 3 (2015): 1-12.
    Published • 10.1007/s11357-015-9799-4
  134. Ribeiro, Miguel; Nunes, Fernando M.; Guedes, Sofia; Domingues, Pedro; SILVA, Amélia M.; Carrillo, Jose Maria; Rodriguez-Quijano, Marta; Branlard, Gérard; Igrejas, Gilberto. "Efficient chemo-enzymatic gluten detoxification: reducing toxic epitopes for celiac patients improving functional properties". Scientific Reports 5 - (2015): 18041-18041.
    Published • 10.1038/srep18041
  135. Soares, Jorge Pinto; Silva, Ana Inês; SILVA, Amélia M.; Almeida, Vanessa; Teixeira, João Paulo; Matos, Manuela; Gaivão, Isabel; Mota, Maria Paula. "Effects of physical exercise training in DNA damage and repair activity in humans with different genetic polymorphisms of hOGG1 (Ser326Cys)". Cell Biochemistry and Function 33 8 (2015): 519-524.
    Published • 10.1002/cbf.3134
  136. Andreani, T.; Fangueiro, J.F.; José, S.; Santini, A.; Silva, A.M.; Souto, E.B.; Andreani, Tatiana; et al. "Hydrophilic polymers for modified-release nanoparticles: A review of mathematical modelling for pharmacokinetic analysis". Current Pharmaceutical Design 21 22 (2015): 3090-3096. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938650711&partnerID=MN8TOARS.
    Published • 10.2174/1381612821666150531163617
  137. Macedo, Ana S.; Quelhas, Sara; SILVA, Amélia M.; Souto, Eliana B.. "Nanoemulsions for delivery of flavonoids: formulation and in vitro release of rutin as model drug". Pharmaceutical Development and Technology 19 6 (2014): 677-680.
    Published • 10.3109/10837450.2013.823989
  138. Doktorovova, Slavomira; Shegokar, Ranjita; Fernandes, Lisete; Martins-Lopes, Paula; SILVA, Amélia M.; Müller, Rainer H.; Souto, Eliana B.. "Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying". Pharmaceutical Development and Technology 19 8 (2014): 922-929.
    Published • 10.3109/10837450.2013.840846
  139. Doktorovova, Slavomira; SILVA, Amélia M.; Gaivão, Isabel; Souto, Eliana B.; Teixeira, João P.; Martins-Lopes, Paula. "Comet assay reveals no genotoxicity risk of cationic solid lipid nanoparticles". Journal of Applied Toxicology 34 4 (2014): 395-403.
    Published • 10.1002/jat.2961
  140. Monteiro-Cardoso, Vera F.; SILVA, Amélia M.; Oliveira, Maria M.; Peixoto, Francisco; Videira, Romeu A.. "Membrane lipid profile alterations are associated with the metabolic adaptation of the Caco-2 cells to aglycemic nutritional condition". Journal of Bioenergetics and Biomembranes 46 1 (2014): 45-57.
    Published • 10.1007/s10863-013-9531-y
  141. Fangueiro, Joana F.; Andreani, Tatiana; Egea, Maria A.; Garcia, Maria L.; Souto, Selma B.; SILVA, Amélia M.; Souto, Eliana B.. "Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity". International Journal of Pharmaceutics 461 1-2 (2014): 64-73.
    Published • 10.1016/j.ijpharm.2013.11.025
  142. Souza, Ana Luiza Ribeiro de; Andreani, Tatiana; de Oliveira, Rosimeire Nunes; Kiill, Charlene Priscila; Santos, Fernanda Kolenyak dos; Allegretti, Silmara Marques; Chaud, Marco Vinícius; et al. "In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment". International Journal of Pharmaceutics 463 1 (2014): 31-37.
    Published • 10.1016/j.ijpharm.2013.12.022
  143. Doktorovova, Slavomira; Souto, Eliana B.; SILVA, Amélia M.. "Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – A systematic review of in vitro data". European Journal of Pharmaceutics and Biopharmaceutics 87 1 (2014): 1-18.
    Published • 10.1016/j.ejpb.2014.02.005
  144. Sousa, Cristina P.; Azevedo, Jorge T.; SILVA, Amélia M.; Viegas, Carlos A.; Reis, Rui L.; Gomes, Manuela E.; Dias, Isabel R.. "Serum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep". Acta Veterinaria Hungarica 62 2 (2014): 205-214.
    Published • 10.1556/AVet.2013.049
  145. Doktorovová, Slavomira; Santos, Dario L.; Costa, Inês; Andreani, Tatiana; Souto, Eliana B.; SILVA, Amélia M.. "Cationic solid lipid nanoparticles interfere with the activity of antioxidant enzymes in hepatocellular carcinoma cells". International Journal of Pharmaceutics 471 1-2 (2014): 18-27.
    Published • 10.1016/j.ijpharm.2014.05.011
  146. Severino, Patrícia; Andreani, Tatiana; Jäger, Alessandro; Chaud, Marco V.; Santana, Maria Helena A.; SILVA, Amélia M.; Souto, Eliana B.. "Solid lipid nanoparticles for hydrophilic biotech drugs: Optimization and cell viability studies (Caco-2 & HEPG-2 cell lines)". European Journal of Medicinal Chemistry 81 - (2014): 28-34.
    Published • 10.1016/j.ejmech.2014.04.084
  147. Andreani, Tatiana; Souza, Ana Luiza R. de; Kiill, Charlene P.; Lorenzón, Esteban N.; Fangueiro, Joana F.; Calpena, Ana Cristina; Chaud, Marco V.; et al. "Preparation and characterization of PEG-coated silica nanoparticles for oral insulin delivery". International Journal of Pharmaceutics 473 1-2 (2014): 627-635.
    Published • 10.1016/j.ijpharm.2014.07.049
  148. Fangueiro, Joana F.; Parra, Alexander; SILVA, Amélia M.; Egea, Maria A.; Souto, Eliana B.; Garcia, Maria L.; Calpena, Ana C.. "Validation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate". International Journal of Pharmaceutics 475 1-2 (2014): 181-190.
    Published • 10.1016/j.ijpharm.2014.08.053
  149. Andreani, Tatiana; Kiill, Charlene P.; Souza, Ana Luiza R. de; Fangueiro, Joana F.; Fernandes, Lisete; Doktorovová, Slavomira; Santos, Dario L.; et al. "Surface engineering of silica nanoparticles for oral insulin delivery: Characterization and cell toxicity studies". Colloids and Surfaces B: Biointerfaces 123 - (2014): 916-923.
    Published • 10.1016/j.colsurfb.2014.10.047
  150. Fangueiro, Joana F.; Andreani, Tatiana; Fernandes, Lisete; Garcia, Maria L.; Egea, Maria A.; SILVA, Amélia M.; Souto, Eliana B.. "Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation". Colloids and Surfaces B: Biointerfaces 123 - (2014): 452-460.
    Published • 10.1016/j.colsurfb.2014.09.042
  151. Silva, Amélia M.; Miranda, Andreia; Fernandes, Elisabete; Santos, Susana; Fraga, Irene; Santos, Dario L.; Dias, Albino A.; Bezerra, Rui M.. "Endopolysaccharides from Ganoderma resinaceum, Phlebia rufa, and Trametes versicolor Affect Differently the Proliferation Rate of HepG2 Cells". Applied Biochemistry and Biotechnology 169 6 (2013): 1919-1926.
    Published • 10.1007/s12010-013-0107-4
  152. Santos, Isis S.; Ponte, Bruno M.; Boonme, Prapaporn; Silva, Amélia M.; Souto, Eliana B.. "Nanoencapsulation of polyphenols for protective effect against colon–rectal cancer". Biotechnology Advances 31 5 (2013): 514-523.
    Published • 10.1016/j.biotechadv.2012.08.005
  153. Andreani, Tatiana; Sofia Macedo, Ana; F. Ferreira, Sandra; M. Silva, Amelia; Rosmaninho, Aristoteles; B. Souto, Eliana. "Topical Targeting Therapies for Sexually Transmitted Diseases". Current Nanoscience 8 4 (2012): 486-490.
    Published • 10.2174/157341312801784348
  154. Severino, Patrícia; Andreani, Tatiana; Macedo, Ana Sofia; Fangueiro, Joana F.; Santana, Maria Helena A.; Silva, Amélia M.; Souto, Eliana B.. "Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery". Journal of Drug Delivery 2012 2012 (2012): 1-10.
    Published • 10.1155/2012/750891
  155. Doktorovova, S.; Shegokar, R.; Martins-Lopes, P.; Silva, A.M.; Lopes, C.M.; Müller, R.H.; Souto, E.B.. "Modified Rose Bengal assay for surface hydrophobicity evaluation of cationic solid lipid nanoparticles (cSLN)". European Journal of Pharmaceutical Sciences 45 5 (2012): 606-612.
    Published • 10.1016/j.ejps.2011.12.016
  156. Souza, Ana Luiza Ribeiro; Andreani, Tatiana; Nunes, Fernando M.; Cassimiro, Douglas Lopes; Almeida, Adélia Emília; Ribeiro, Clóvis Augusto; Sarmento, Victor Hugo Vitorino; et al. "Loading of praziquantel in the crystal lattice of solid lipid nanoparticles". Journal of Thermal Analysis and Calorimetry 108 1 (2011): 353-360.
    Published • 10.1007/s10973-011-1871-4
  157. Doktorovova, S.; Shegokar, R.; Rakovsky, E.; Gonzalez-Mira, E.; Lopes, C.M.; Silva, A.M.; Martins-Lopes, P.; Muller, R.H.; Souto, E.B.. "Cationic solid lipid nanoparticles (cSLN): Structure, stability and DNA binding capacity correlation studies". International Journal of Pharmaceutics 420 2 (2011): 341-349.
    Published • 10.1016/j.ijpharm.2011.08.042
  158. Dias, I.R.; Viegas, C.A.; Silva, A.M.; Pereira, H.F.; Sousa, C.P.; Carvalho, P.P.; Cabrita, A.S.; et al. "Haematological and biochemical parameters in Churra-da-Terra-Quente ewes from the northeast of Portugal". ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA 62 2 (2010): 265-272.
    Published • 10.1590/S0102-09352010000200004
  159. Souto, Eliana B.; Martins-Lopes, Paula; Lopes, Carla M.; Gaivão, Isabel; Silva, Amélia M.; Guedes-Pinto, Henrique. "A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery Systems (LDS)". Journal of Biomedical Nanotechnology 5 4 (2009): 317-322.
    Published • 10.1166/jbn.2009.1041
  160. Misler, Stanley; Zhou, Zhuan; Dickey, Adam S.; Silva, Amelia M.; Pressel, David M.; Barnett, David W.. "Electrical activity and exocytotic correlates of biphasic insulin secretion from ß-cells of canine islets of Langerhans: Contribution of tuning two modes of Ca 2+ entry-dependent exocytosis to two modes of glucose-induced electrical activity". Channels 3 3 (2009): 181-193. http://www.landesbioscience.com/journals/channels/article/8972/10-MislerCHAN3-3.pdf.
    Published • 10.4161/chan.3.3.8972
  161. Misler, Stanley; Silva, Amelia M.; Barnett, David W.; Dickey, Adam S.; Misler, S.; Silva, A.M.; Barnett, D.; Dickey, A.S.. "Phasic and tonic modes of depolarization-exocytosis coupling in ß-cells of porcine islets of Langerhans". Channels 3 2 (2009): 101-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-67049160299&partnerID=MN8TOARS.
    Published • 10.4161/chan.3.2.7866
  162. Silva, A.M.; Dickey, A.S.; Barnett, D.W.; Misler, S.; Silva, Amelia M.; Dickey, Adam S.; Barnett, David W.; Misler, Stanley. "Ion channels underlying stimulus-exocytosis coupling and its cell-to-cell heterogeneity in ß-cells of transplantable porcine islets of Langerhans". Channels 3 2 (2009): 91-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-67049171644&partnerID=MN8TOARS.
    Published • 10.4161/chan.3.2.7865
  163. Misler, S.; Zhou, Z.; Dickey, A.S.; Silva, A.M.; Pressel, D.M.; Barnett, D.W.. "Electrical activity and exocytotic correlates of biphasic insulin secretion from beta-cells of canine islets of Langerhans: contribution of tuning two modes of Ca2+ entry-dependent exocytosis to two modes of glucose-induced electrical activity.". Channels (Austin, Tex.) 3 3 (2009): 181-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-74349091093&partnerID=MN8TOARS.
  164. Rosário, Luís M.; BARBOSA, Rui M.; ANTUNES, Célia M.; BALDEIRAS, Inês E.; SILVA, Amélia M.; TOMÉ, Ângelo R.; SANTOS, Rosa M.. "Regulation by Glucose of Oscillatory Electrical Activity and 5-HT/Insulin Release from Single Mouse Pancreatic Islets in Absence of Functional KATP Channels". Endocrine Journal 55 4 (2008): 639-650.
    Published • 10.1507/endocrj.K07E-131
  165. Silva, Amélia M.; Rodrigues, Ricardo J.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Misler, Stanley; Rosário, Luís M.; Santos, Rosa M.. "Electrophysiological and Immunocytochemical Evidence for P2X Purinergic Receptors in Pancreatic ß Cells". Pancreas 36 3 (2008): 279-283.
    Published • 10.1097/MPA.0b013e31815a8473
  166. Morais, Raul; Valente, A.; Almeida, J.C.; Silva, Amélia M.; Soares, Salviano; Reis, M.J.C.S.; Valentim, R.; Azevedo, Jorge. "Concept study of an implantable microsystem for electrical resistance and temperature measurements in dairy cows, suitable for estrus detection". Sensors and Actuators A: Physical 132 1 (2006): 354-361.
    Published • 10.1016/j.sna.2006.04.011
  167. Silva, A. M; Liu-Gentry, J.; Dickey, A.S.; Barnett, D.W.; Misler, S.. "alpha-Latrotoxin increases spontaneous and depolarization-evoked exocytosis from pancreatic islet beta-cells". JOURNAL OF PHYSIOLOGY-LONDON 565 3 (2005): 783-799.
    Published • 10.1113/jphysiol.2005.082586
  168. Barbosa, Rui M.; Silva, Amelia M.; Tome, Angelo R.; Stamford, Jonathan A.; Santos, Rosa M.; Rosario, Luis M.. "Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics". JOURNAL OF PHYSIOLOGY-LONDON 510 1 (1998): 135-143.
    Published • 10.1111/j.1469-7793.1998.135bz.x
  169. Barbosa, R.M.; Silva, A.M.; Tome, A.R.; Stamford, J.A.; Santos, R.M.; Rosario, L.M.. "Erratum: Real time electrochemical detection of 5-HT/Insulin secretion from single pancreatic islets: Effect of glucose and K+ depolarization (Biochemical and Biophysical Research Communications (1996) 228 (100-104))". Biochemical and Biophysical Research Communications 231 2 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0030978941&partnerID=MN8TOARS.
  170. Barbosa, Rui M.; Silva, Amélia M.; Tome, Angelo R.; Stamford, Jonathan A.; Santos, Rosa M.; Rosario, Luis M.. "Real Time Electrochemical Detection of 5-HT/Insulin Secretion from Single Pancreatic Islets: Effect of Glucose and K+Depolarization". Biochemical and Biophysical Research Communications 228 1 (1996): 100-104.
    Published • 10.1006/bbrc.1996.1622
  171. Salgado, A.P.; Silva, A.M.; Santos, R. M.; Rosário, L.M.. "Multiphasic action of glucose and alpha-keto isocaproic acid on the intracellular pH of isolated mouse pancreatic beta-cells.". Journal of Biological Chemistry 271 15 (1996): 8738-8467.
    Published
  172. Salgado, A.P.; Silva, A.M.; Santos, R.M.; Rosário, L.M.. "Multiphasic action of glucose and a-ketoisocaproic acid on the cytosolic pH of pancreatic ß-cells: Evidence for an acidification pathway linked to the stimulation of Ca2+ influx". Journal of Biological Chemistry 271 15 (1996): 8738-8746. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029945645&partnerID=MN8TOARS.
  173. Silva, Amélia M.; Rosario, Luis M.; Santos, Rosa M.; Silva, A.M.; Rosário, L.M.; Santos, R.M.. "Background Ca2+ influx mediated by a dihydropyridine- and voltage insensitive channel in pancreatic *-cells: modulation by Ni2+, diphenylamine-2-carboxylate and glucose metabolism.". Journal of Biological Chemistry 269 25 (1994): 17095-17103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028180449&partnerID=MN8TOARS.
    Published
  174. Rosario, Luis M.; Barbosa, Rui M.; Antunes, Célia M.; Silva, Amélia M.; Abrunhosa, Antero J.; Santos, Rosa M.. "Bursting electrical activity in pancreatic beta-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels". Pflugers Archiv European Journal of Physiology 424 5-6 (1993): 439-447.
    Published • 10.1007/BF00374906
  175. Santos, Rosa M.; Barbosa, Rui M.; Silva, Amélia M.; Antunes, Célia M.; Rosario, Luis M.. "High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic ß-cells during blockade of K(ATP) channels". Biochemical and Biophysical Research Communications 187 2 (1992): 872-879.
    Published • 10.1016/0006-291X(92)91278-X
Thesis / Dissertation
  1. Teixeira, Isabel Cristina Marinho. "Extratos de plantas da família Lamiaceae ricos em polifenóis: estudos in vitro perspetivando aplicações biomédicas / Extracts from plants from the Lamiaceae family rich in polyphenols: in vitro studies with a view to biomedical applications". Master, 2018. http://hdl.handle.net/10348/8501.
  2. Pereira, Irina Patrícia Brito. "Evaluation of the Nanoencapsulation Effects on the Anti-proliferative Activity of Monoterpenes using Human Skin Cell Models". Master, 2018. http://hdl.handle.net/10348/8391.
  3. Coutinho , Tiago Emanuel Pinto. "Extratos de Cucurbita ficifolia Bouché: análise do perfil polifenólico e dos seus potenciais bioativos usando modelos celulares / Cucurbita ficifolia Bouché extracts: analysis of the polyphenolic profile and its bioactive potentials using cellular models". Master, 2018. http://hdl.handle.net/10348/9091.
  4. Sario, Sara Judite Pais. "In vitro and in vivo evaluation of the biological effects of Celuvein® and its components". Master, 2017. http://hdl.handle.net/10348/8153.
  5. Gomes, Carlos Alexandre Martins. "Correlation between chemical composition and bioactivity of Thymus carnosus Boiss. extracts". Master, 2017. http://hdl.handle.net/10348/7895.
  6. Queiroz, Marcelo Flávio Jesus. "Evaluation of grape stems extracts from cultivar ‘Sousão’ as a source of compounds inhibitors of oxidative stress in vitro using keratinocytes". Master, 2017. http://hdl.handle.net/10348/8016.
  7. Fagundes, Sandra Isabel Gonçalves. "Corantes esquarílicos com potencial utilização em terapia fotodinâmica do cancro". Master, 2016. http://hdl.handle.net/10348/6146.
  8. Silva, Patrícia Alexandra Sobrinho da. "Caracterização do perfil hematológico e dos parâmetros bioquímicos do soro da cabra (Capra aegagrus hircus) e a sua comparação com os de indivíduos da sub-família Caprinae já caracterizados". Master, 2016. http://hdl.handle.net/10348/5400.
  9. Rodrigues, Tânia Raquel Dias. "Papel da adenosina na insuficiência cardíaca num modelo animal de hipertensão pulmonar". Master, 2016. http://hdl.handle.net/10348/6387.
  10. Friães, Sofia Manuela Pinto. "Síntese, caracterização espetroscópica de novos corantes esquarílicos assimétricos e sua avaliação como potenciais fotossensibilizadores em terapia fotodinâmica". Master, 2015. http://hdl.handle.net/10348/6414.
  11. Santos, Susana Cláudia Conceição. "Síntese, caracterização espectroscópica de novos corantes esquarílicos assimétricos e avaliação do seu potencial na terapia fotodinâmica, usando as linhas celulares MCF-7 e BT-474". Master, 2015. http://hdl.handle.net/10348/6171.
  12. Gonçalves, Mafalda Bessa Martins. "Targeting the adenosine A2B receptor may attenuate cardiac remodelling secondary to pulmonary hypertension". Master, 2015. http://hdl.handle.net/10348/5556.
  13. Silva, Sambrine Deolinda Jesus da. "Caracterização química dos extratos aquosos e hidro-etanólicos de tomilho vulgar (Thymus vulgaris L.), tomilho bela-luz (Thymus mastichina L.) e tomilho limão (Thymus x citriodorus L.) e avaliação da sua toxicidade usando modelos in vitro". Master, 2014. http://hdl.handle.net/10348/4780.
  14. Andreani, Tatiana. "Silica nanoparticles in oral peptide delivery for diabetes Mellitus control and treatment". PhD, 2014. http://hdl.handle.net/10348/4787.
  15. Santos, Constance Elise Silva dos. "Caracterização química dos extratos de carqueja (Pterospartum tridentatum, Wilk) e de erva de S. Roberto (Geranium robertianum, L.) e avaliação da sua toxicidade usando modelos in vitro". Master, 2014. http://hdl.handle.net/10348/4781.
  16. Ferreira, Sandrine dos Santos. "Caracterização dos extratos de subprodutos de frutos, Citrus reticulata Blanco e Cucurbita ficifolia Bouché e avaliação dos seus efeitos biológicos usando células animais em cultura". Master, 2014. http://hdl.handle.net/10348/5715.
  17. Jesus, Dário Lúcio Ferreira de. "ß-cell reserve in insulin resistant pregnant mice". Master, 2013. http://hdl.handle.net/10348/2841.
  18. Silva, Amélia Maria Lopes Dias da. "Receptores P2 e modulação da actividade secretora da célula B pancreática". PhD, 2003. http://hdl.handle.net/10316/1606.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09/01 - Current Avaliação do efeito de extratos de cogumelos em modelos celulares e enzimáticos: ação anti-proliferativa, anti-inflamatória e anti-envelhecimento / Evaluation of the effect of mushroom extracts in cellular and enzymatic models: anti-proliferative, anti-inflammatory and anti-aging action
Supervisor
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/09/01 - Current Dual loading of phytochemicals for wound healing: nanoformulation design and characterization
Supervisor
 Engenharia Biomédica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/10/01 - Current Phenolic compounds for malignant melanoma prophylaxis: from nanoformulation to in-vitro 3D/ in vivo proof-of-concept
Supervisor of Tiago Emanuel Coutinho
 Ciências Químicas e Biológicas (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/09/01 - Current Alterações da função mitocondrial com a idade: influência da atividade física habitual / Changes in mitochondrial function with age: influence of habitual physical activity
Co-supervisor
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/09/01 - Current Valorisation of grapevine (Vitis vinifera L.) by-products: bioactive compounds for new and improved cosmeceuticals
Co-supervisor
 Cadeias de Produção Agrícola - da mesa ao campo (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2019/12/01 - Current Search for new functional foods: chemical profiling of endemic Thymus species and in vitro assessment of their bioactivities
Supervisor of MARTINS-GOMES, Carlos Alexandre
 Ciências Químicas e Biológicas (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2019/09/01 - Current Evaluation of seaweeds protective effects against genetic damage induced by alpha ionizing radiation – resources valorization and health innovation
Co-supervisor of FERREIRA, João Miguel Mendes
 Doutoramento em Ciências Químicas e Biológicas (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2019/04/05 - Current DNA damage and repair response of chemotherapy in human colorectal and breast cancer
Co-supervisor
 Ciências Químicas e Biológicas (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/09/01 - 2024/03/11 Phenolic acids as modulators of chemotherapeutic agents: a biomedical perspective using breast cancer cell lines
Supervisor
 Engenharia Biomédica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/09/01 - 2024/01/19 Prospeção De Compostos Bioativos De Ambientes Pristinos: Uma Aplicação Biomédica / Prospecting for Bioactive Compounds from Pristine Environments: A Biomedical Application
Co-supervisor
 Engenharia Biomédica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/10/01 - 2023/03/31 Acompanhamento das Técnicas de Rotina do INNO Laboratório Veterinário / Monitoring of INNO Veterinary Laboratory’s Routine Techniques
Co-supervisor
 Biologia Clínica Laboratorial (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2016 - 2023 EXPLORING THE POTENCIAL OF PRUNUS LUSITANICA L: FROM CHEMICAL CHARACTERISATION TO BIOACTIVITIES AIMING THE DEVELOPMENT OF NEW PRODUCTS
Supervisor of ANA CRISTINA DOS SANTOS ABRAÃO
 Cadeias de produção agrícola - da mesa ao campo (associação) (PhD)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências Agrárias e Veterinárias, Portugal
2021/09/01 - 2022/11/25 Papel dos recetores P2X4 na disfunção cardíaca direita num modelo animal de hipertensão arterial pulmonar / Role of P2X4 receptors in right heart dysfunction in an animal model of pulmonary arterial hypertension
Co-supervisor
 Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/04/01 - 2022/09/23 Production and Valorisation of labdanum oleoresin from Cistus ladanifer L.
Supervisor of David Passos Morgado Franco Frazão
Cadeias de Produção Agrícola - da mesa ao campo (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/02/01 - 2022/07/21 Inibição enzimática por extratos de tomilhos como ferramenta anti-diabética / Enzyme inhibition by thyme extracts as an anti-diabetic tool
Supervisor
 Bioquímica (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/01/09 - 2022/07/15 In vitro, in vivo models for drug delivery systems used in Age related macular degeneration
Co-supervisor of Ana Rita Venscelau FERNANDES
Universidade do Porto Faculdade de Farmácia, Portugal
2016/03/01 - 2022/05/16 Evaluation of the potential health benefits of Sambucus nigra L.
Co-supervisor of Sandrine dos Santos FERREIRA,
Cadeias de Produção Agrícola - da mesa ao campo (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2018/10/01 - 2022/02/10 Parâmetros hematológicos: estágio no Laboratório de Patologia Clínica da Unilabs / Hematological parameters: internship at the Unilabs Clinical Pathology Laboratory
Co-supervisor
 Biologia Clínica Laboratorial (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/02/01 - 2021/09/24 Atividade anti-inflamatória de óleos essenciais de tomilhos e dos seus componentes / Anti-inflammatory activity of thyme essential oils and their components
Supervisor
 Bioquímica (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/02/01 - 2021/07/23 Inibição de colinesterases por óleos essenciais de tomilhos e seus componentes. / Inhibition of cholinesterases by thyme essential oils and their components.
Supervisor
 Biologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/02/01 - 2021/07/05 Deposição de filmes finos de TiO2 por MOCVD em aço inox e estudo da biocompatibilidade / Deposition of TiO2 thin films by MOCVD on stainless steel and biocompatibility study
Co-supervisor
 Engenharia Biomédica (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/09/01 - 2021/06/11 Caracterização e estudo da incidência do Mieloma múltiplo e Plasmocitoma na região de Trás-os-Montes e Alto Douro / Characterization and study of the incidence of Multiple Myeloma and Plasmacytoma in the Trás-os-Montes and Alto Douro region
Co-supervisor of Débora Coelho PINHO
 Biologia Clínica Laboratorial (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/02/01 - 2020/07/15 Comparação dos efeitos citotóxicos e genotóxicos de um pesticida em solução e encapsulado / Comparison of the cytotoxic and genotoxic effects of a pesticide in solution and encapsulated
Supervisor
 Genética e Biotecnologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2014/06/01 - 2020/05/27 Chemical composition and biological activity of a range of thyme species in Portugal under a changing environment
Supervisor of TAGHOUTI, Meriem
 Programa Doutoral AgriChains: Agriculture Production Chains – from fork to farm (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/09/01 - 2020/03/03 Ação de compostos fenólicos bioativos na atividade anti-proliferativa e anti-inflamatória, usando modelos celulares / Action of bioactive phenolic compounds in anti-proliferative and anti-inflammatory activity, using cellular models
Supervisor of Adriano José Sousa MORAIS,
Engenharia Biomédica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/09/01 - 2020/01/14 Caracterização química e bioatividades de cogumelos comestíveis / Chemical characterization and bioactivities of edible mushrooms
Supervisor
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/09/01 - 2019/07/30 Antiproliferative and antioxidant role of selected flavonoids: A cellular approach
Supervisor of DURÃES, Tiago José Monteiro
Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/09/01 - 2019/04/03 Composição e Bioatividade de óleos essenciais de Thymus carnosus: comparação entre o material vegetal obtido por cultura in vitro vs campo / Composition and Bioactivity of Thymus carnosus essential oils: comparison between plant material obtained by in vitro culture vs field
Co-supervisor of Paulo Jorge Oliveira SAMPAIO,
Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/09/01 - 2019/03/06 The Role of Insulin Resistance in Metabolic Reprogramming and Lineage Commitment
Co-supervisor of Dário Lúcio Ferreira de JESUS
 Graduate Program in Areas of Basic and Applied Biology - GABBA (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/01 - 2019/01/30 Evaluation of the Nanoencapsulation Effects on Anti-proliferative Activity of Monoterpenes using Human Skin Cell Models
Co-supervisor of Irina Patrícia Brito PEREIRA
 Mestrado em Genética Molecular, Comparativa e Tecnológica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/09/01 - 2018/12/13 Extratos de Cucurbita ficifolia Bouché: análise do perfil polifenólico e dos seus potenciais bioativos usando modelos celulares / Cucurbita ficifolia Bouché extracts: analysis of the polyphenolic profile and its bioactive potentials using cellular models
Supervisor of Tiago Emanuel Pinto COUTINHO,
Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2016/09/01 - 2018/02/09 Extracts from plants from the Lamiaceae family rich in polyphenols: in vitro studies looking at their biomedical applications. / Extratos de plantas da família Lamiaceae ricos em polifenóis: estudos in vitro perspetivando as suas aplicações Biomédicas.
Supervisor of Isabel Cristina Marinho TEIXEIRA
 Engenharia Biomédica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2016/09/01 - 2017/07/26 In vitro and in vivo evaluation of the biological effects of Celuvein® and its components
Co-supervisor
 Mestrado em Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017/02/01 - 2017/07/18 Efeito de extratos aquosos de Santolina rosmarinifolia L. na viabilidade e na atividade anti-inflamatória / Effect of aqueous extracts of Santolina rosmarinifolia L. on viability and anti-inflammatory activity
Co-supervisor
 Bioquímica (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2015/09/01 - 2017/07/03 Effect of phenolics from tangerine peel extract on cell viability and modulation of apoptosis regulatory protein levels. / Efeito de fenólicos do extrato de casca de tangerina na viabilidade celular e na modulação dos níveis de proteínas reguladoras da apoptose.
Supervisor
 Biologia Clínica Laboratorial (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2015/09/01 - 2017/02/22 Evaluation of grape stems extracts from cultivar "Sousão" as a source of compounds inhibitors of oxidative stress in vitro using keratinocytes.
Supervisor of Marcelo Flávio Jesus QUEIROZ
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2015/09/01 - 2017/01/17 Correlation between chemical composition and bioactivity of Thymus carnosus Boiss. extracts
Supervisor
 Mestrado em Bioquímica, (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2017 - 2017 CORRELATION BETWEEN CHEMICAL COMPOSITION AND BIOACTIVITY OF THYMUS CARNOSUS BOISS. EXTRACTS
Supervisor of CARLOS ALEXANDRE MARTINS GOMES
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2017 - 2017 Cellular mechanisms underlying the potential phototherapeutic action induced by squarylic dyes /MECANISMOS CELULARES SUBJACENTES À POTENCIAL AÇÃO FOTODINÂMICA INDUZIDA POR CORANTES CIANÍNICOS ESQUARÍLICOS
Supervisor of JOÃO RAFAEL RODRIGUES SIOPA
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2017 - 2017 EVALUATION OF GRAPE STEMS EXTRACTS FROM CULTIVAR "SOUSÃO" AS A SOURCE OF COMPOUNDS INHIBITORS OF OXIDATIVE STRESS IN VITRO USING KERATINOCYTES
Supervisor of MARCELO FLÁVIO JESUS QUEIROZ
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2017 - 2017 IN VITRO AND IN VIVO EVALUATION OF THE BIOLOGICAL EFECTS OF CELUVEIN®
Co-supervisor of SARA JUDITE PAIS SARIO
 Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2015/09/01 - 2016/10/03 Síntese, caracterização espetroscópica de cianinas esquarilicas, tioesquarilicas e ditioesquarilicas e avaliação do seu potencial como fotossesibilizadores em terapia fotodinâmica / Synthesis, spectroscopic characterization of squarylic, thiosquarylic and dithiosquarylic cyanines and evaluation of their potential as photosensitizers in photodynamic therapy
Co-supervisor of Tânia Catarina Dias FERNANDES
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2014/09/01 - 2016/05/06 Síntese, caraterização espetroscópica de novos corantes esquarílicos e avaliação da sua citotoxicidade em células Caco-2 e HepG2.
Co-supervisor
 Mestrado em Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/09/01 - 2016/04/11 Cationic lipid nanomedicines for the treatment of diabetic retinopathy
Co-supervisor of FANGUEIRO, Joana Filipa Peixoto
 Doutoramento em Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/09/01 - 2015/11/13 Novas perspetivas sobre o papel da sinalização pela adenosina na progressão da hipertensão pulmonar para a insuficiência cardíaca
Co-supervisor
 Mestrado em Genética Molecular Comparativa e Tecnológica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2013/09/01 - 2015/10/22 Síntese, caracterização espetroscópica de novos corantes esquarílicos assimétricos e avaliação do seu potencial na terapia fotodinâmica, usando as linhas celulares BT-474 e MFC-7 / Synthesis, spectroscopic characterization of new asymmetric squarylic dyes and evaluation of their potential in photodynamic therapy, using the BT-474 and MFC-7 cell lines
Supervisor of Susana Cláudia Conceição SANTOS
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2013/09/01 - 2015/07/13 Síntese, caracterização espetroscópica de novos corantes assimétricos e sua avaliação como potenciais fotossensibilizadores em Terapia Fotodinâmica
Co-supervisor
 Mestrado em Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2013/09/01 - 2014/12/15 Papel da adenosina na insuficiência cardíaca num modelo animal de hipertensão pulmonar
Co-supervisor of RODRIGUES, Tânia Raquel Dias
Mestrado em Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2010/09/01 - 2014/07/21 Silica nanoparticles in oral peptide delivery for Diabetes Mellitus control and treatment
Co-supervisor of ANDREANI, Tatiana
 Doutoramento em Ciências Químicas e Biológicas (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/09/01 - 2014/05/23 Characterization of fruit by-product extracts, Citrus reticulata Blanco and Cucurbita ficifolia Bouché and evaluation of their biological effect using animal cells in culture / Caracterização dos extratos de subprodutos de frutos, Citrus reticulata Blanco e Cucurbita ficifolia Bouché e avaliação dos seus efeito biológico usando células animais em cultura
Supervisor of Sandrine dos Santos FERREIRA
 Biologia Clínica Laboratorial (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/09/01 - 2014/02/19 Chemical characterization of extracts of Carqueja (Pterospartum tridentatum, Wilk) and St. Robert's herb (Geranium robertianum, L.) and evaluation of their toxicity using in vitro models / Caracterização química dos extratos de Carqueja (Pterospartum tridentatum, Wilk) e de erva de S. Roberto (Geranium robertianum, L.) e avaliação da sua toxicidade usando modelos in vitro
Supervisor of Constance Elise Silva dos SANTOS
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/09/01 - 2014/02/17 Chemical characterization of aqueous and hydro-ethanolic extracts of thyme vulgaris (Thymus vulgaris L.), thyme Bela-luz (Thymus mastichina L.) and thyme lemon (Thymus x citriodorus L.) and evaluation of their toxicity using in vitro models / Caracterização química dos extratos aquosos e hidro-etanólicos de tomilho vulgar (Thymus vulgaris L.), tomilho bela-luz (Thymus mastichina L.) e tomilho limão (Thymus x citriodorus L.) e avaliação da sua toxicidade usando modelos in vitro
Supervisor of Sambrine Deolinda Jesus da SILVA
 Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/09/01 - 2013/12/13 Corantes esquarílicos com potencial aplicação na terapia fotodinâmica do cancro
Co-supervisor
 Mestrado em Bioquímica (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/09/01 - 2013/09/25 Contributo para a caracterização da medula óssea da Cabra (Capra aegagrus hircus) por citometria de fluxo
Supervisor
 Mestrado em Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2010/09/01 - 2012/07/23 Caracterização do perfil hematológico e dos parâmetros bioquímicos do soro da Cabra (Capra aegagrus hircus) e sua comparação com os de indivíduos da sub-família Caprinae já caracterizados / Characterization of the hematological profile and biochemical parameters of Goat serum (Capra aegagrus hircus) and its comparison with those of already characterized individuals of the Caprinae subfamily.
Supervisor
 Biologia Clínica Laboratorial (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2010/09/09 - 2011/12/21 Regeneration of insulin secreting beta cells
Supervisor of Dário Lúcio Ferreira de JESUS
 Biologia Clínica Laboratorial (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2009/09/01 - 2011/01/13 Creation and characterization of mitochondrial DNA-depleted human Huntington’s disease and control derived lymphoblasts.
Co-supervisor
 Mestrado em Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2009/09/01 - 2010/12/20 Role of metastasis suppressor Raf Kinase Inhibitory Protein (RKIP) in Cervical Cancer
Co-supervisor
 Mestrado em Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2009/09/01 - 2010/11/18 Functional consequences of chemokine receptor hetero-dimerization.
Co-supervisor
 Mestrado em Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/11/04 Desarrollo de sistemas nanoestructurados conteniendo Lactoferrina para el tratamiento de patologías oculares / Development of nanostructured systems containing Lactoferrin for the treatment of ocular pathologies
(Thesis) Main arguer
 Ana Laura López Machado (PhD)
Universitat de Barcelona Departament de Farmàcia i Tecnologia Farmacèutica i Fisicoquímica, Spain
2022/09/23 Valorisation of Cistus ladanifer L.: From production to evaluation of raw materials
Supervisor
 David Passos Morgado Franco Frazão (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/05/27 Chemical composition and biological activity of a range of thyme species in Portugal under a changing environment
Thesis Member
 Meriem Taghouti (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/02/14 Macroalgas marinhas como alimentos funcionais e potencial biotecnológico - promoção da integridade do ADN e mecanismos subjacentes. /Marine macroalgae as functional foods and biotechnological potential - promoting DNA integrity and underlying mechanisms.
(Thesis) Main arguer
 Ana Margarida Lourenço Silva Marques (PhD)
Universidade de Aveiro, Portugal
2019/12/20 Diet in prevention and treatment of colorectal cancer: the role of selected legumes of the Mediterranean diet
(Thesis) Main arguer
 Catarina Isabel Guedes Teixeira (PhD)
Universidade do Minho, Portugal
2017/12/20 Hormetic induction of antioxidant defenses for promotion of healthy aging.
(Thesis) Main arguer
 Ana Cristina Carvalho (PhD)
Universidade do Minho, Portugal
2017/05/26 Cancer Stem Cells in Human Osteosarcoma: Tracking Stemness to Target Chemoresistance
Thesis Member
 Sara Raquel Martins Neves (PhD)
Universidade de Coimbra, Portugal
2016/10/27 Purinergic signaling in activated ventricular myofibroblasts as a putative pharmacological target to prevent cardiac remodeling
(Thesis) Main arguer
 Mariana de Sousa Certal Gomes (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/04/11 Cationic lipid nanomedicines for the treatment of diabetic retinopathy
Thesis Member
 Joana Filipa Peixoto Fangueiro (PhD)
Universidade de Coimbra, Portugal
2016/01/26 Pharmacological evaluation of plant extracts from Chapada Diamantina (Bahia, Brazil): Focus on antioxidant and cytotoxic properties
(Thesis) Main arguer
 Cláudia Marta Libreiro de Pinho (PhD)
Universidade do Minho, Portugal
2015/04/10 Asociación de pranoprofeno a sistemas nanoestructurados para la administración tópica
(Thesis) Main arguer
 Guadalupe del Carmen Abrego Escobar (PhD)
Universitat de Barcelona, Spain
2015/03/05 Study of the preventive role of physical exercise on mutagenesis. DNA damage and repair mechanisms in human lymphocytes: effects of physical exercise training
Thesis Member
 Jorge Frederico Pinto Soares (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2014/07/21 Silica nanoparticles in oral peptide delivery for diabetes mellitus control and treatment
Thesis Member
 Tatiana Andreani (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2014/03/14 Estudos toxicológicos de materiais nano-estruturados de carbono. Algumas aplicações farmacológicas
(Thesis) Main arguer
 Sandra Marina de Almeida Santos (PhD)
Universidade de Coimbra, Portugal
2013/12/20 Study of the mechanisms underlying the cytotoxic effects of bivine lactoferrin on the brest cancer cells
(Thesis) Main arguer
 Yunley Zhang (PhD)
Universidade do Minho, Portugal
2012/11/30 Optimización y caracterización fisicoquímica de sistemas nanoestructurados de liberación controlada de flurbiprofeno
(Thesis) Main arguer
 Estefanía Vega Freire (PhD)
Universitat de Barcelona, Spain
2012/06/04 Regulação da actividade da Na/K-ATPase por glucose em célula beta pancreática na ausência e na presença de um estado de intolerância à glicose”
(Thesis) Arguer
 Ana Cristina Bugalho Oliveira Rodrigues Costa (PhD)
Universidade de Évora, Portugal
2011/12/19 Triamcinolone acetonide for ocular administration: Innovations in drug delivery and therapeutics
(Thesis) Main arguer
 Joana Almeida Rangel de Araújo (PhD)
Universitat de Barcelona, Spain

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/09/01 - Current Cell Biochemistry / Bioquímica Celular Bioquímica (Mestrado integrado) Universidade de Trás-os-Montes e Alto Douro, Portugal
2016/09/01 - Current Biochemistry / Bioquímica Engenharia Biomédica (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal
2011/09/01 - Current Biochemistry for Health Sciences / Bioquímica para as Ciências da Saúde Bioquímica (Mestrado integrado) Universidade de Trás-os-Montes e Alto Douro, Portugal
2008/09/01 - Current Cellular Dynamics / Dinâmica Celular Biologia Clínica Laboratorial (Mestrado integrado) Universidade de Trás-os-Montes e Alto Douro, Portugal
2007/09/01 - Current Fisiologia Celular / Cell Physiology Bioquímica (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal
2006/02/01 - Current Fisiologia Celular / Cell Physiology Licenciatura em Bioquímica (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal
2004/09/01 - 2017/07/31 Biofísica / Byophysics Genética e Biotecnologia (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal
1996/03/03 - 2016/06/30 Biofísica / Byophysics Medicina Veterinária (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal
2005/09/01 - 2014/07/31 Biofísica / Byophysics Bioquímica (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal
2003/09/01 - 2010/07/31 Biofísica / Byophysics Ecologia Aplicada (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal
Distinctions

Award

2023 World’s Top 2% Scientists list (2023)
2022 BEST PAPER AWARD - FIRST PRIZE (Molecules)
2022 World's Top 2% Scientists list (2022)
2021 Excellent Oral and Poster Presentation Award
2021 World's Top 2% Scientists list (2021)
2020 World's Top 2% Scientists list (2020)
2001 1st prize for the best oral communication of the III ICETA-UTAD Research Days