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Rita Catarina Álvaro Manguinhas has a BSc degree in Biochemistry, recently completed an MSc degree in Biopharmaceutical Sciences and also attended a one-year specialization course in Forensic Medical Sciences. She completed 3 internships in her career, namely at Gulbenkian Institute of Science, National Institute of Legal Medicine and Forensic Sciences (INMLCF, I.P.) - Forensic Chemistry and Toxicology Service and University of Notthingham, United Kingdom. She is co-author of two full-papers, both in Q1 journals, one in Scientific reports (2016, IF 4.256) and another in Food and Chemical Toxicology (2020, IF 4.679). More recently, she published her first article and 1st author at Antioxidants (2020, IF 5.014), titled "Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion". Moreover, she was also author/co-author of two oral and two poster presentations in national and international congresses/meetings. Furthermore, Rita Manguinhas recently presented an oral communication at the 2020 Annual Meeting of the Portuguese Pharmacology Society (07/02/2020). She is currently a Research Trainee at Instituto de Investigação do Medicamento from the Faculty of Pharmacy, University of Lisbon.
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Identification

Personal identification

Full name
Rita Catarina Álvaro Manguinhas

Citation names

  • Manguinhas, Rita
  • Manguinhas, R.

Author identifiers

Ciência ID
2513-DF3A-080D
ORCID iD
0000-0001-5371-0178
Researcher Id
AAP-2392-2021
Scopus Author Id
57214258589

Email addresses

  • rmanguinhas@campus.ul.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Other Medical Sciences - Forensic Science

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/05/01 - 2025/04/30
Ongoing
 Farmácia (Doutoramento)
Major in Toxicologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/10/01 - 2019/12/18
Concluded
 Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Inhibition of the redox function of APE1 as a potential strategy to improve the efficacy of cisplatin in non-small cell lung cancer cells" (THESIS/DISSERTATION)
 18
2019/10/30 - 2019/10/30
Concluded
 Food Metabolites and the Impact of Microbiota Workshop (Outros)
Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
 16
2019/10/01 - 2019/10/02
Concluded
 Cell Migration Workshop: Concepts, Mechanisms and Techniques (Outros)
Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
 20
2016/09/15 - 2017/07/18
Concluded
 Ciências Médico-Legais (Especialização pós-licenciatura)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 18
2015/09/29 - 2015/10/02
Concluded
 Course on Animal Handling and Experimentation (mice and zebrafish) (Outros)
Instituto Gulbenkian de Ciência, Portugal
2012/09 - 2015/06
Concluded
 Bioquímica (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"The Role of Actin Cytoskeleton in Synaptic Plasticity Maintenance" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2019/12/19 - 2021/04/30 Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2018/07/02 - 2018/07/27 Research Trainee (Research) University of Nottingham Faculty of Engineering, United Kingdom
University of Nottingham Department of Chemical and Environmental Engineering, United Kingdom
2015/07/01 - 2015/12/31 Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2014/12/02 - 2015/06/30 Research Trainee (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal

Others

Category
Host institution 		Employer
2021/05/01 - Current PhD student Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2018/10/01 - 2019/12/18 Master Thesis student Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2016/09/01 - 2017/06/30 Internship Instituto Nacional de Medicina Legal e Ciências Forenses, Portugal
Instituto Nacional de Medicina Legal e Ciências Forenses Delegação do Sul, Portugal
Outputs

Publications

Conference poster
  1. Manguinhas, R.; Fernandes, A.S.; Costa, J.G.; Saraiva, N.; Camões, S.P.; Gil, N.; Rosell, R.; et al. "Increased Cytotoxicity and Impairment of Cell Migration and Invasion by E3330 in cisplatin-treated NSCLC cells". Paper presented in iMed.Ulisboa Meeting 2021, 2021.
  2. Manguinhas, Rita; Fernandes, Ana S.; Costa, João G.; Saraiva, Nuno; Camões, Sérgio P.; Gil, Nuno; Rosell, Rafael; et al. "Impact of E3330 in Non-Small Cell Lung Cancer Cells Viability and Migration Upon Cisplatin Treatment". Paper presented in 11th iMed.ULisboa Postgraduate & 4th i3DU Students Meeting, 2019.
  3. Manguinhas, Rita; Fonseca, Rosalina; Szabó, Eszter. "The interplay between neuronal activity and the modulation of actin dynamics mimic the setting of an LTD synaptic tag". Paper presented in 10th FENS Forum of Neuroscience, 2016.
Journal article
  1. "A narrative review of the migration and invasion features of non-small cell lung cancer cells upon xenobiotic exposure: insights from in vitro studies". Translational Lung Cancer Research 10 6 (2021): 2698-2714. http://dx.doi.org/10.21037/tlcr-21-121.
    Published • 10.21037/tlcr-21-121
  2. Manguinhas, Rita; Fernandes, Ana S.; Costa, João G.; Saraiva, Nuno; Camões, Sérgio P.; Gil, Nuno; Rosell, Rafael; et al. "Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion". Antioxidants 9 6 (2020): 550. http://dx.doi.org/10.3390/antiox9060550.
    Published • 10.3390/antiox9060550
  3. Costa, João G.; Keser, Vanessa; Jackson, Constance; Saraiva, Nuno; Guerreiro, Íris; Almeida, Nuno; Camões, Sérgio P.; et al. "A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells". Food and Chemical Toxicology 136 (2020): 111076. http://dx.doi.org/10.1016/j.fct.2019.111076.
    Published • 10.1016/j.fct.2019.111076
  4. Szabó, Eszter C.; Manguinhas, Rita; Fonseca, Rosalina. "The interplay between neuronal activity and actin dynamics mimic the setting of an LTD synaptic tag". Scientific Reports 6 33685 (2016): http://dx.doi.org/10.1038/srep33685.
    Published • 10.1038/srep33685
Thesis / Dissertation
  1. Manguinhas, Rita. "Inhibition of the redox function of APE1 as a potential strategy to improve the efficacy of cisplatin in non-small cell lung cancer cells". Master, Universidade de Lisboa Faculdade de Farmácia, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/02/11 Impact of the SOD mimic MnTnHex-2-PyP5+ and its combination with cisplatin in non-small cell lung cancer cells in vitro SPF Meeting 2022 - Portuguese Pharmacology Society
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)
2020/02/07 APE1 redox inhibitor E3330 as a potentiator of cisplatin therapy in non-small cell lung cancer SPF Meeting 2020 - Portuguese Pharmacology Society
Faculdade de Farmácia da Universidade do Coimbra (Coimbra, Portugal)
2019/10/03 Anticancer Properties of Thymoquinine in 786-O Renal Cancer Cells NutRedox COST Action Meeting
Universidade Lusófona de Humanidades e Tecnologias (Lisboa, Portugal)
2016/11/11 New Method using GC-MS for rapid detection and quantification of Opiates in low volume whole blood samples III Conferência do Instituto Nacional de Medicina Legal e Ciências Forenses
Universidade de Coimbra (Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/10/10 - 2019/10/12 Conference staff helping at the organization and logistics of the 11th Inernational Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC). (2019/10/10 - 2019/10/12)
Congress (Other)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC), Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/02/09 - 2022/02/11 Attended to the SPF Meeting 2022 (Portuguese Pharmacology Society)
Congress
 SPF Meeting 2022
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/02/17 - 2021/02/19 Attended to the SPF Meeting 2021 (Portuguese Pharmacology Society)
Congress
 SPF Meeting 2021
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/30 - 2019/10/02 NutRedOx Training School in Molecular Nutrition
Workshop
 NutRedOx Training School in Molecular Nutrition
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2019/07/15 - 2019/07/15 Attended to the 11th iMed.ULisboa PostgraduateStudents Meeting & 4rd i3DU Meeting
Conference
 11th iMed.ULisboa PostgraduateStudents Meeting & 4rd i3DU Meeting
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2019/02/06 - 2019/02/08 Attended to the SPF Meeting 2019 (Portuguese Pharmacology Society)
Congress
 SPF Meeting 2019
Universidade do Porto Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2020 - Current Portuguese Society of Pharmacology (SPF, Sociedade Portuguesa de Farmacologia) Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/11/26 - 2021/11/26 Aula sobre Antioxidantes: APE1 redox inhibitor E3330 as a potentiator of cisplatin therapy in non-small cell lung cancer Mestrado em Qualidade Alimentar e Saúde Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/05/18 - 2021/05/18 CBIOS PhD Students Meeting: APE1 redox inhibitor E3330 as a potentiator of cisplatin therapy in non-small cell lung cancer Doutoramento em Ciências da Saúde (Doutoramento) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
Distinctions

Award

2018 PARSUK Xperience 2018 Scholarship
Portuguese Association of Researchers and Students in the United Kingdom (PARSUK), United Kingdom

Fundação Calouste Gulbenkian, Portugal

Title

2015 Category B FELASA certification for animal experimentation
Direcção-Geral de Alimentação e Veterinária, Portugal