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I hold a PhD in Cell and Molecular Biology by the Karolinska Institute in Stockholm (2001), where I have worked under the supervision of Thomas Perlmann. I have joined the laboratory of François Guillemot as postdoctoral researcher, initially at the Institute de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, and later at the MRC - National Institute for Medical Research (NIMR) in London. My research interests stand at cross roads between Neurosciences, Developmental Biology and Brain Cancer. I have established my own research group at Instituto Gulbenkian de Ciência (IGC) in 2011. Since 2020 I head the Stem Cells & Neurogenesis laboratory at i3S Institute for Research and Innovation in Health of the University of Porto. Work at my group is focused on transcriptional mechanisms that regulate neural stem cell maintenance and differentiation in the vertebrate embryo, and how these may be deployed in pathological conditions such as brain cancer. I have supervised 5 PhD students (3 completed, 2 ongoing) and 8 MSc students (7 completed, 1 ongoing). From 2018 to 2021, I was president of the board of the Portuguese Society for Developmental Biology (SPBD). My lab is currently funded by FCT grant 2022.05447.PTDC (until 31 Decembre 2024) and New Frontiers in Research Fund NFRFT-2022-00327 (from the Canadian Tri-Agency) running until 2029.
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Identification

Personal identification

Full name
Diogo Pinto da Cruz Sampaio e Castro

Citation names

  • Castro, Diogo S.

Author identifiers

Ciência ID
2514-6976-58C2
ORCID iD
0000-0001-8178-9565
Google Scholar ID
aUZR6w4AAAAJ&hl
Researcher Id
I-6217-2016
Scopus Author Id
7102871028

Email addresses

  • diogo.castro@i3s.up.pt (Professional)

Telephones

Telephone
  • 226074955 (Professional)

Addresses

  • i3S Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Swedish Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2001/01/26
Concluded
 PhD in Cell and Molecular Biology (Doktor (PhD))
Karolinska Institutet, Sweden
"Functional Studies on the orphan receptor Nurr1 and related retinoid receptors" (THESIS/DISSERTATION)
 non applicable
1994/08/31
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"non applicable" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2020/01/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011/04/01 - 2019/12/31 Principal Investigator (Research) Instituto Gulbenkian de Ciência, Portugal
2003/01/01 - 2010/07/31 Postdoc (Research) MRC National Institute for Medical Research, United Kingdom
2002/01/01 - 2002/12/31 Postdoc (Research) Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
Projects

Grant

Designation Funders
2023/03 - Current A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders
NFRFT-2022-00327
Co-Principal Investigator (Co-PI)
Government of Canada
Ongoing
2023/01 - Current Towards a comprehensive view of ZEB transcription factors in glioblastoma
2022.05447.PTDC
Team member
Fundação para a Ciência e Tecnologia
2018/08/01 - 2022/07/31 Function and regulation of mitotic bookmarking by RBPJ/Notch during vertebrate neurogenesis
LISBOA-01-0145-FEDER-029663
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2016/02/29 The transcriptional network of the zinc-finger factor ZEB1 and its function in the embryonic nervous sytem and glioma development
303644
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2013/07/01 - 2015/12/31 Transcriptional integration of Notch and Proneural pathways in vertebrate neurogenesis
PTDC/NEU-NMC/0315/2012
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/03/21 - 2015/09/30 The transcriptional network of the zinc-finger protein Zeb1 and its function in neural stem/progenitor cells
PTDC/SAU-NMC/117538/2010
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/05/01 - 2013/12/31 Characterization of a neurogenic program activated by the proneural factor Mash1
PTDC/SNEU-NMC/0315/2012
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/03/01 - Current The dynamics of Mitotic Bookmarking by RBPJ/Notch Pathway and its role in Neurogenesis
PD/BD/139177/2018
Supervisor
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2015/06/01 - 2019/12/31 Mitotic inheritance of the neural stem/progenitor cell network
PD / BD / 105999 / 2014
Supervisor
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/12/30 - 2018/12/29 Trsncriptional control of vertebrate neurogenesis
IF/00413/2012
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/09/01 - 2015/06/30 A transcriptional cross-talk between Proneural and Notch pathways in vertebrate neurogenesis
SFRH/BPD/79251/2011
Supervisor
Fundação para a Ciência e a Tecnologia, Portugal
2011/04/01 - 2015/03/31 Charaterization of the Zeb1 function in NS/progenitor cells and in a human glioblastoma model – a genomic approach
SFRH / BD / 74111 / 2010
Supervisor
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/07/01 - 2013/10/31 Myt1 function in neurogenesis and its interaction with the proneural transcription network: a genomics approach
SFRH / BD / 51178 / 2010
Supervisor
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Soares, M.A.F.; Castro, D.S.. Chromatin immunoprecipitation from mouse embryonic tissue or adherent cells in culture, followed by next-generation sequencing. 2018.
    10.1007/978-1-4939-7380-4_5
Journal article
  1. Miguel V. Silva; Diogo S. Castro. "Mitotic bookmarking by transcription factors: be aware of redundancy". Trends in Biochemical Sciences (2024): https://doi.org/10.1016/j.tibs.2024.03.003.
    10.1016/j.tibs.2024.03.003
  2. Mario A.F. Soares; Diogo S. Soares; Vera Teixeira; Abeer Heskol; Raul Bardini Bressan; Steven M. Pollard; Raquel A. Oliveira; Diogo S. Castro. "Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells". Genes & Development (2023): https://doi.org/10.1101/gad.350810.123.
    10.1101/gad.350810.123
  3. Mário A. F. Soares; Raquel A. Oliveira; Diogo S. Castro. "Function and regulation of transcription factors during mitosis-to-G1 transition". Open Biology (2022): https://doi.org/10.1098/rsob.220062.
    10.1098/rsob.220062
  4. Soares, Diogo S.; Homem, Catarina C.F.; Castro, Diogo S.. "Function of Proneural Genes Ascl1 and Asense in Neurogenesis: How Similar Are They?". Frontiers in Cell and Developmental Biology 10 (2022): http://dx.doi.org/10.3389/fcell.2022.838431.
    10.3389/fcell.2022.838431
  5. Carolina Noronha; Ana Sofia Ribeiro; Ricardo Taipa; Diogo S. Castro; Joaquim Reis; Cláudia Faria; Joana Paredes. "Cadherin Expression and EMT: A Focus on Gliomas". Biomedicines (2021): https://doi.org/10.3390/biomedicines9101328.
    10.3390/biomedicines9101328
  6. "Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding". Neuron 109 18 (2021): 2847-2863.e11. http://dx.doi.org/10.1016/j.neuron.2021.07.007.
    10.1016/j.neuron.2021.07.007
  7. Mário A.F. Soares; Diogo S. Soares; Vera Teixeira; Abeer Heskol; Raul Bardini Bressan; Steven M. Pollard; Raquel A. Oliveira; Diogo S. Castro. "Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells". Genes & Development 35 13-14 (2021): 1020-1034. https://doi.org/10.1101/gad.348174.120.
    10.1101/gad.348174.120
  8. Castro, Diogo S.. "Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.642697.
    10.3389/fcell.2021.642697
  9. Falcão, Ana Mendanha; Meijer, Mandy; Scaglione, Antonella; Rinwa, Puneet; Agirre, Eneritz; Liang, Jialiang; Larsen, Sara C.; et al. "PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination". Cell Reports 27 4 (2019): 1090-1102.e10. http://dx.doi.org/10.1016/j.celrep.2019.03.108.
    10.1016/j.celrep.2019.03.108
  10. Yang, Shanzheng; Toledo, Enrique M.; Rosmaninho, Pedro; Peng, Changgeng; Uhlén, Per; Castro, Diogo S.; Arenas, Ernest. "A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration". Communications Biology 1 1 (2018): http://dx.doi.org/10.1038/s42003-018-0080-0.
    10.1038/s42003-018-0080-0
  11. Rosmaninho, Pedro; Mükusch, Susanne; Piscopo, Valerio; Teixeira, Vera; Raposo, Alexandre ASF; Warta, Rolf; Bennewitz, Romina; et al. "Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion". The EMBO Journal 37 15 (2018): e97115. http://dx.doi.org/10.15252/embj.201797115.
    10.15252/embj.201797115
  12. Francisca F. Vasconcelos; Diogo S. Castro. "Coordinating neuronal differentiation with repression of the progenitor program: Role of the transcription factor MyT1". Neurogenesis 4 1 (2017): e1329683-e1329683. https://doi.org/10.1080/23262133.2017.1329683.
    10.1080/23262133.2017.1329683
  13. Vasconcelos, Francisca F.; Sessa, Alessandro; Laranjeira, Cátia; Raposo, Alexandre A.S.F.; Teixeira, Vera; Hagey, Daniel W.; Tomaz, Diogo M.; et al. "MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis". Cell Reports 17 2 (2016): 469-483. http://dx.doi.org/10.1016/j.celrep.2016.09.024.
    10.1016/j.celrep.2016.09.024
  14. Castro, Diogo S. "One more factor joins the plot: Pbx1 regulates differentiation and survival of midbrain dopaminergic neurons". The EMBO Journal 35 18 (2016): 1957-1959. http://dx.doi.org/10.15252/embj.201695353.
    10.15252/embj.201695353
  15. Singh, Shalini; Howell, Danielle; Trivedi, Niraj; Kessler, Ketty; Ong, Taren; Rosmaninho, Pedro; Raposo, Alexandre ASF; et al. "Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition". eLife 5 (2016): http://dx.doi.org/10.7554/elife.12717.
    10.7554/elife.12717
  16. Singh, S.; Howell, D.; Trivedi, N.; Kessler, K.; Ong, T.; Rosmaninho, P.; Raposo, A.A.S.F.; et al. "Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition". eLife 5 MAY2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84971612316&partnerID=MN8TOARS.
    10.7554/eLife.12717
  17. Castro, Diogo. "Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal". Genome Biology 25 1 (2015): 41-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920692345&partnerID=MN8TOARS.
    10.1101/gr.173435.114
  18. Raposo, A.A.S.F.; Vasconcelos, F.F.; Drechsel, D.; Marie, C.; Johnston, C.; Dolle, D.; Bithell, A.; et al. "Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis". Cell Reports 10 9 (2015): 1544-1556. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931281902&partnerID=MN8TOARS.
    10.1016/j.celrep.2015.02.025
  19. Heng, J.I.-T.; Qu, Z.; Ohtaka-Maruyama, C.; Okado, H.; Kasai, M.; Castro, D.; Guillemot, F.; Tan, S.-S.. "The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development". Cerebral Cortex 25 3 (2015): 806-816. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928345368&partnerID=MN8TOARS.
    10.1093/cercor/bht277
  20. Garcez, P.P.; Diaz-Alonso, J.; Crespo-Enriquez, I.; Castro, D.; Bell, D.; Guillemot, F.. "Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1". Nature Communications 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924365667&partnerID=MN8TOARS.
    10.1038/ncomms7474
  21. Monteiro, C.B.; Costa, M.F.; Reguenga, C.; Lima, D.; Castro, D.S.; Monteiro, F.A.. "Paired related homeobox protein-like 1 (Prrxl1) controls its own expression by a transcriptional autorepression mechanism". FEBS Letters 588 18 (2014): 3475-3482. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908691391&partnerID=MN8TOARS.
    10.1016/j.febslet.2014.08.006
  22. Vasconcelos, F.F.; Castro, D.S.. "Transcriptional control of vertebrate neurogenesis by the proneural factor ascll". Frontiers in Cellular Neuroscience 8 DEC (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84914172949&partnerID=MN8TOARS.
    10.3389/fncel.2014.00412
  23. Borromeo, M.D.; Meredith, D.M.; Castro, D.S.; Chang, J.C.; Tung, K.-C.; Guillemot, F.; Johnson, J.E.. "A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord". Development (Cambridge) 141 14 (2014): 2803-2812. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903978000&partnerID=MN8TOARS.
    10.1242/dev.105866
  24. Castro, Diogo. "Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons". Cell 155 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886784309&partnerID=MN8TOARS.
    10.1016/j.cell.2013.09.028
  25. Sun, W.; Hu, X.; Lim, M.H.K.; Ng, C.K.L.; Choo, S.H.; Castro, D.S.; Drechsel, D.; et al. "TherMos: Estimating protein-DNA binding energies from in vivo binding profiles". Nucleic Acids Research 41 11 (2013): 5555-5568. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878882810&partnerID=MN8TOARS.
    10.1093/nar/gkt250
  26. Seibt, J.; Armant, O.; Le Digarcher, A.; Castro, D.; Ramesh, V.; Journot, L.; Guillemot, F.; Vanderhaeghen, P.; Bouschet, T.. "Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon.". PloS one 7 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876421796&partnerID=MN8TOARS.
  27. Castro, D.S.; Martynoga, B.; Parras, C.; Ramesh, V.; Pacary, E.; Johnston, C.; Drechsel, D.; et al. "A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets". Genes and Development 25 9 (2011): 930-945. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955676827&partnerID=MN8TOARS.
    10.1101/gad.627811
  28. Castro, D.S.; Guillemot, F.. "Old and new functions of proneural factors revealed by the genome-wide characterization of their transcriptional targets". Cell Cycle 10 23 (2011): 4026-4031. http://www.scopus.com/inward/record.url?eid=2-s2.0-82855170864&partnerID=MN8TOARS.
    10.4161/cc.10.23.18578
  29. Pacary, E.; Heng, J.; Azzarelli, R.; Riou, P.; Castro, D.; Lebel-Potter, M.; Parras, C.; et al. "Proneural transcription factors regulate different steps of cortical neuron migration through rnd-mediated inhibition of RhoA signaling". Neuron 69 6 (2011): 1069-1084. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952763999&partnerID=MN8TOARS.
    10.1016/j.neuron.2011.02.018
  30. Jacob, J.; Storm, R.; Castro, D.S.; Milton, C.; Pla, P.; Guillemot, F.; Birchmeier, C.; Briscoe, J.. "Insm (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain". Development 136 14 (2009): 2477-2485. http://www.scopus.com/inward/record.url?eid=2-s2.0-69649097844&partnerID=MN8TOARS.
    10.1242/dev.034546
  31. Skowronska-Krawczyk, D.; Chiodini, F.; Ebeling, M.; Alliod, C.; Kundzewicz, A.; Castro, D.; Ballivet, M.; et al. "Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis". Development 136 22 (2009): 3767-3777. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450159851&partnerID=MN8TOARS.
    10.1242/dev.033449
  32. Geoffroy, C.G.; Critchley, J.A.; Castro, D.S.; Ramelli, S.; Barraclough, C.; Descombes, P.; Guillemot, F.; Raineteau, O.. "Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues". Stem Cells 27 4 (2009): 847-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-65649103653&partnerID=MN8TOARS.
    10.1002/stem.17
  33. Gohlke, J.M.; Armant, O.; Parham, F.M.; Smith, M.V.; Zimmer, C.; Castro, D.S.; Nguyen, L.; et al. "Characterization of the proneural gene regulatory network during mouse telencephalon development". BMC Biology 6 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-42649091463&partnerID=MN8TOARS.
    10.1186/1741-7007-6-15
  34. Castro, Diogo S.. "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature 455 7209 (2008): 114-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-51349143015&partnerID=MN8TOARS.
    10.1038/nature07198
  35. Ge, W.; He, F.; Kim, K.J.; Blanchi, B.; Coskun, V.; Nguyen, L.; Wu, X.; et al. "Coupling of cell migration with neurogenesis by proneural bHLH factors". Proceedings of the National Academy of Sciences of the United States of America 103 5 (2006): 1319-1324. http://www.scopus.com/inward/record.url?eid=2-s2.0-31944439553&partnerID=MN8TOARS.
    10.1073/pnas.0510419103
  36. Castro, D.S.; Skowronska-Krawczyk, D.; Armant, O.; Donaldson, I.J.; Parras, C.; Hunt, C.; Critchley, J.A.; et al. "Proneural bHLH and Brn Proteins Coregulate a Neurogenic Program through Cooperative Binding to a Conserved DNA Motif". Developmental Cell 11 6 (2006): 831-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751315519&partnerID=MN8TOARS.
    10.1016/j.devcel.2006.10.006
  37. He, F.; Ge, W.; Martinowich, K.; Becker-Catania, S.; Coskun, V.; Zhu, W.; Wu, H.; et al. "A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis". Nature Neuroscience 8 5 (2005): 616-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944442861&partnerID=MN8TOARS.
    10.1038/nn1440
  38. Nordzell, M.; Aarnisalo, P.; Benoit, G.; Castro, D.S.; Perlmann, T.. "Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1". Biochemical and Biophysical Research Communications 313 1 (2004): 205-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346220219&partnerID=MN8TOARS.
    10.1016/j.bbrc.2003.11.079
  39. Hermanson, E.; Joseph, B.; Castro, D.; Lindqvist, E.; Aarnisalo, P.; Wallén, A.; Benoit, G.; et al. "Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells". Experimental Cell Research 288 2 (2003): 324-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043065330&partnerID=MN8TOARS.
    10.1016/S0014-4827(03)00216-7
  40. Bertrand, N.; Castro, D.S.; Guillemot, F.. "Proneural genes and the specification of neural cell types". Nature Reviews Neuroscience 3 7 (2002): 517-530. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036631456&partnerID=MN8TOARS.
    10.1038/nrn874
  41. Castro, D.S.; Hermanson, E.; Joseph, B.; Wallén, Å.; Aarnisalo, P.; Heller, A.; Perlmann, T.. "Induction of Cell Cycle Arrest and Morphological Differentiation by Nurr1 and Retinoids in Dopamine MN9D Cells". Journal of Biological Chemistry 276 46 (2001): 43277-43284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035900751&partnerID=MN8TOARS.
    10.1074/jbc.M107013200
  42. Wallén, A.; Castro, D.S.; Zetterström, R.H.; Karlén, M.; Olson, L.; Ericson, J.; Perlmann, T.. "Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem". Molecular and Cellular Neuroscience 18 6 (2001): 649-663. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035684381&partnerID=MN8TOARS.
    10.1006/mcne.2001.1057
  43. Castro, D.S.; Arvidsson, M.; Bolin, M.B.; Perlmann, T.. "Activity of the Nurr1 carboxyl-terminal domain depends on cell type and integrity of the activation function 2". Journal of Biological Chemistry 274 52 (1999): 37483-37490. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033601290&partnerID=MN8TOARS.
    10.1074/jbc.274.52.37483
  44. Wagner, J.; Åkerud, P.; Castro, D.S.; Holm, P.C.; Canals, J.M.; Snyder, E.Y.; Perlmann, T.; Arenas, E.. "Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes". Nature Biotechnology 17 7 (1999): 653-659. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032980340&partnerID=MN8TOARS.
    10.1038/10862
  45. Castro, Diogo S.. "Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation". journal of Biological Chemistry 272 14 (1997): 9443-9449. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030960780&partnerID=MN8TOARS.
    10.1074/jbc.272.14.9443
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/06/06 Hierarchical reactivation of transcription during mitosis-to-G1 transition in neural stem cells EMBO Workshop: Neural stem cells - from basic understanding to translational applications
EMBO (Kyllini, Greece)
2019/10/11 The 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Lisbon, Portugal The 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Lisbon, Portugal)
2019/10/07 Invited speaker at The Notch Meeting XI, Athens, Greece The Notch Meeting, XI
(Athens, Greece)
2019/02/20 Research seminar at the Cajal Institute (Madrid) Invited speaker seminar
Cajal Institute, Madrid (Madrid, Spain)
2018/12/05 Research seminar at CEDOC Chronic Diseases Research Center (Lisbon) Invited speaker seminar
CEDOC Chronic Diseases Research Center (Lisbon) (Lisbon, Portugal)
2018/11/09 Invited speaker at the Joint Meeting of the Portuguese, Spanish and French Societies for Developmental Biology Joint Meeting of the Portuguese, Spanish and French Societies for Developmental Biology
Portuguese Society for Developmental Biology (Porto, Portugal)
2018/07/10 Research seminar at IMBA Institute of Molecular Biotechnology (Viena) Invited speaker seminar
IMBA Institute of Molecular Biotechnology (Viena, Austria)
2018/05/30 Zeb1 potentiates genome-wide gene transcription in synergy with Lef1 to promote tumor invasion in glioblastoma The Stem Cell Niche Conference, Copenhagen Bioscience Conferences
(Copenhagen, Denmark)
2017/11/27 Research seminar at IBENS Institut de Biologie de l’École Normale Supérieure (Paris) Invited speaker seminar
Institut de Biologie de l’École Normale Supérieure (IBENS) (Paris, France)
2017/05/26 The transcription factor MyT1 counteracts the neural progenitor program to promote vertebrate neurogenesis XV Meeting of the Portuguese Society for Neuroscience
(Braga, Portugal)
2017/03/10 Research seminar at I3S Instituto de Investigação e Inovação em Saúde (Porto) Invited speaker seminar
Instituto de Investigação e Inovação em Saúde (I3s) (Porto, Portugal)
2017/01/19 Research seminar at Department of Experimental and Health Sciences, Universitat Pompeu Fabra (Barcelona) Invited speaker seminar
Department of Experimental and Health Sciences, Universitat Pompeu Fabra (Barcelona, Spain)
2016/12/14 Research seminar at Department of Medical Biochemistry and Biophysics, Karolinska Institute Invited speaker seminar
Department of Medical Biochemistry and Biophysics, Karolinska Institute (Stockholm, Sweden)
2016/10/28 Research seminar at Department of Developmental Genetics, Université Libre de Bruxelles Invited speaker seminar
Department of Developmental Genetics, Université Libre de Bruxelles (Charleroi, Belgium)
2016/10/26 Research seminar at GIGA Neuroscinces Programme, University of Liège Invited speaker seminar
GIGA Neuroscinces Programme, University of Liège (Liège, Belgium)
2016/08/29 Research seminar at Department of Medical Biochemistry and Biophysics, Karolinska Institute Invited speaker seminar
Department of Medical Biochemistry and Biophysics, Karolinska Institute (Stockholm, Sweden)
2015/11/20 Research seminar at Max Delbrück Center for Molecular Medicine, Berlin Invited speaker seminar
Max Delbrück Center for Molecular Medicine (Berlin, Germany)
2015/06/25 Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis 2015 Annual Meeting of ISSCR
ISSCR International Society for Stem Cell Research (Stockholm, Sweden)
2015/06/05 Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1/Mash1 XIV Meeting of the Portuguese Society for Neurosciences
Portuguese Society for Neurosciences (Póvoa de Varzim, Portugal)
2015/05/12 Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis Epigenetics and disease workshop
EU Life Consortium (Copenhagen, Denmark)
2014/11/26 Research seminar at IMB Institute of Molecular Biology, Mainz Invited speaker seminar
Institute of Molecular Biology (IMB), Mainz University (Mainz, Germany)
2014/10/01 Synergistic and antagonistic interactions between Ascl1 and Notch transcriptional programs during vertebrate neurogenesis Notch signaling in the nervous system
The Notch Meeting VIII (Athens, Greece)
2014/09/18 Research seminar at Brain and Spine Institute, Université Pierre et Marie Curie Invited speaker seminar
Brain and Spine Institute, Université Pierre et Marie Curie (Paris, France)
2013/10/01 Research seminar at Institute of Molecular Medicine, Lisbon Invited speaker seminar
Institute of Molecular Medicine (Lisbon, Portugal)
2012/08/02 Transcriptional control of neural stem cell proliferation and differentiation by the proneural factor Ascl1 XXVII Annual Meeting
Brazilian Federation of the Societies for Experimental Biology (São Paulo, Brazil)
2012/08/01 Proneural transcriptional programs in vertebrate neurogenesis • Advanced Program in Neuroscience and RioSfN Symposium: Neurogenesis and Neurogenic Niches: From Biology to Therapy
Sociedade Brasileira de Neurociências e Comportamento (Rio de Janeiro, Brazil)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/10/01 - Current Regulation of vertebrate neurogenesis by O-GlcNAcylation: a focus on Ascl1
Supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/03/01 - Current The dynamics of Mitotic Bookmarking by RBPJ/Notch Pathway and its role in Neurogenesis
Supervisor of Abeer Heskol
Instituto Gulbenkian de Ciência, Portugal
2021/12/01 - 2022/12/19 Developing tools for studying the regulation of Ascl1 transcriptional activity by multisite phosphorylation.
Supervisor
Universidade de Aveiro, Portugal
2021/07/01 - 2022/12/02 Comparative studies on transcription factors ZEB1 and ZEB2 in glioblastoma
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
2021/01/01 - 2022/10/01 Transcriptional regulation of neurogenesis by the proneural factor Ascl1
Supervisor
Universidade do Minho, Portugal
2020/10/01 - 2022/03/16 Post-translational regulation of Ascl1 activity in vertebrate neurogenesis
Supervisor
 Master in in Developmental and Evolutionary Biology (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/01 - 2020/12/01 Functional studies on ZEB transcription factors in glioblastoma
Supervisor
 Biomedical Sciences (Master)
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2015/08/01 - 2019/12/09 Mitotic inheritance of the neural stem/progenitor cell network
Supervisor of Mário António Fonseca Soares
Instituto Gulbenkian de Ciência, Portugal
2017/09/01 - 2019/04/22 Investigating a possible mitotic bookmarking function of Ascl1
Supervisor of Diogo Sampaio Soares
Universidade de Lisboa Faculdade de Medicina, Portugal
2011/04 - 2016/11 Function of the transcription factor ZEB1 in Glioblastoma
Supervisor of Pedro Mota Prego Rosmaninho
 Biologia Integrativa e Biomedicina (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2015 Insights on the function of MyT1L in Ascl1 mediated neuronal reprogramming
Supervisor of Diogo Miguel Rosa Tomaz
 Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2015 Ascl1 and MyT1 transcriptional networks in vertebrate neurogenesis
Supervisor of Francisca Ferreira de Vasconcelos
 Biologia Integrativa e Biomedicina (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/09/27 - Current Coordination of the SPBD stand at European Researchers´Night 2019 at Natural History and Science Museum of Lisbon (2019/09/27 - 2019/09/27)
Exhibition
2022/10/16 - 2022/10/20 19th International Congress of Developmental Biology (2022/10/16 - 2022/10/20)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Biologia do Desenvolvimento (SPBD), Portugal
2018/11/07 - 2018/11/10 Joint Meeting of the Portuguese, Spanish and French Societies for Developmental Biology (2018/11/07 - 2018/11/10)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Biologia do Desenvolvimento (SPBD), Portugal
2018/09/28 - 2018/09/28 Coordination of the SPBD stand at European Researchers´Night 2018 at Natural History and Science Museum of Lisbon (2018/09/28)
Exhibition (Other)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/29 The role of phosphorylation at Ser119 in the regulation of PRRXL1 transcriptional activity in spinal glutamatergic neurons
(Thesis) Main arguer
 Catarina Vandervoordt (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/11/03 Mechanisms Underlying the Specification of Definitive Hematopoiesis
(Thesis) Arguer
 Rita Alves (PhD)
Lunds Universitet, Sweden
2022/06/23 Toward Chromosome 6 Replacement in hPSCs by Editing Nucleases and Microcell Mediated Chromosome Transfer (MMCT)
(Thesis) Main arguer
 João Carreira (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/04/22 Characterization of Novel Factors Regulating Neural Stem Cell Proliferation, Temporal Fate and Neuronal Diversity
(Thesis) Main arguer
 Graça Marques (PhD)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2020/12/04 Prrxl1 controls the expression of transmitter and transmitter receptor genes in developing dorsal spinal cord
(Thesis) Main arguer
 Marta Samina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/11/26 Txnip has a conserved non-coding regulatory sequence and regulates Meth-induced neuronal effects
(Thesis) Main arguer
 Joana Azevedo (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/07/23 Pre-mRNA splicing and regulation of gene expression after Drosophila egg fertilization
(Thesis) Main arguer
 Pedro Prudêncio (PhD)
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2020/06/19 Role of TET3 enzyme in brain function
(Thesis) Main arguer
 Claudia Antunes (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/11/08 Uncovering the interplay between cell fate specification and progenitor dynamics during the development of the lower rhombic lip
(Thesis) Main arguer
 Ivan Belzunce Guillermo (PhD)
Universitat Pompeu Fabra Departament de Ciences Experimentals i de la Salut Unitat de Biologia Evolutiva i Sistemes Complexos, Spain
2019/02/12 The role of chromosome compaction in the establishment of cell fate
(Thesis) Main arguer
 Marta Isabel Seita Afonso (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 Deciphering key roles of WNTG in globastoma: Mechanistic, Functional and Clinical Insights (ICVS, Braga)
(Thesis) Main arguer
 Celine Saraiva Gonçalves (PhD)
Universidade do Minho, Portugal
2018 Functional characterization of rib-repressing activity of Hox PG10 proteins (IGC, Oeiras)
(Thesis) Main arguer
 Özlem Aybüke Isik (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01 The regulation of Atonal 1 and the origin of hair cells in the inner ear (U. Pompeu Fabra, Barcelona)
(Thesis) Main arguer
 Héctor Gálvez García (PhD)
Universitat Pompeu Fabra, Spain
2017 Role of Mi-2 in chromatin regulation to regulate neural stem cell fate and life-span in Drosophila melanogaster (FCUL, Lisbon)
(Thesis) Main arguer
 Ana Margarida Ramalho Venda (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/11 The role of actin cytoskeleton downstream of the Src oncogene in the earlier events of breast tumour progression (IGC, Oeiras)
Thesis Member
 Sandra Raquel de Oliveira Tavares (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 Gdf1 signalling, Oct4 and the control of vertebrate trunk length (IGC, Oeiras)
Thesis Member
 Ana Rita Aires (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 Mechanisms controlling midbrain dopaminergic neuron development (Karolinska Institutet, Stockholm)
(Thesis) Main arguer
 Shanzheng Yang (PhD)
Karolinska Institutet, Sweden
2015/12 Insight on the molecular mechanisms that control the expression of Prrxl1 in nociceptive neurons (FMUP, Porto)
(Thesis) Main arguer
 Maria Isabel de Sousa Regadas (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2014/11/12 Identification of chromatin components of the actively transcribed expression site in Trypanosoma brucei (FCT-UNL, Lisbon)
(Thesis) Main arguer
 Idálio de Jesus Contreiras Viegas (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/09/19 Ascl1 and Olig2 transcriptional regulations of oligodendrogenesis (Université Pierre et Marie Curie, Paris)
(Thesis) Main arguer
 Adrien Clavairoly (PhD)
Ecole Doctorale Cerveau Cognition Comportement, France
2014 From embryonic stem cells to sensory hair cells: a programming approach (FMUL, Lisbon)
(Thesis) Main arguer
 Aida Costa (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 Unravelling the regulation of DII4 expression and its function during embryonic neurogenesis (FCUL, Lisbon)
(Thesis) Main arguer
 Pedro Miguel Branco Barbacena (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 Novel perspectives on the subependymal zone complexity and modulation (ICVS, Braga)
(Thesis) Main arguer
 Ana Luísa Mendanha Falcão (PhD)
Universidade do Minho, Portugal
2011/01/14 Functional Analysis of the Notch Signaling Cascade in Neural Progenitors (FMUL, Lisbon)
(Thesis) Main arguer
 Filipe André Santos de Castro Vilas-Boas (PhD)
Universidade de Lisboa, Portugal
2011 Regulation of Dll4 expression in cells committing to differentiation in the V2 domain of the developing spinal cord (FCUL, Lisbon)
(Thesis) Main arguer
 Joana Matos das Neves (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 Proneural bHLH Cell population dynamics in mouse retina (FCUL, Lisbon)
(Thesis) Main arguer
 Ricardo Júdice Miragaia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 Estudo da expressão e função das isoformas do factor de transcrição Prrxl1 (FCUP, Porto)
(Thesis) Main arguer
 Mariana Raimundo Pinto de Matos (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2018/01/01 - Current Portuguese Society for Developmental Biology President of the board
2014/01/01 - 2017/12/31 Portuguese Society for Developmental Biology Member of the board

Committee member

Activity description
Role 		Institution / Organization
2017/11/26 - 2017/11/26 Selection of new group leader at IBENS - École Normale Supérieure (Paris)
Member
 Institut de Biologie de l'Ecole Normale Supérieure, France

Interview (tv / radio show)

Program Topic
2016/11/09 - 2016/11/09 Interview on science radio program "Antena 2 Ciência"
2016/10/01 - 2016/10/01 Brief interview on a group publication during news program Bom Dia Portugal General News

Other jury / evaluation

Activity description Institution / Organization
2017/07/03 - 2017/07/04 Evaluation of FCT PhD fellowships in Basic Medicine and Biomedicine Fundação para a Ciência e a Tecnologia, Portugal