Ana Filipa Martins de Almeida (2614-E969-E9A6)

Curriculum Vitae

Ana Filipa Martins de Almeida

Ana Filipa Martins de Almeida holds a Bachelor in Genetics and Biotechnology from University of Trás-os-Montes and Alto Douro (Vila Real, Portugal, 2015) and a Master’s in Molecular Genetics from University of Minho (Braga, Portugal, 2018). During her master, she focused on the critical role of oncogenic KRAS in colorectal cancer giving her expertise in biology and biotechnology and interest to understand complex disease mechanisms at the cellular and molecular levels. She holds company experience working in the multinational drug discovery company Synovo, in Germany, screening immuno-oncology agents for pharmaceutical applications. She decided to continue her academic path and is currently developing her PhD in Tissue Engineering, Regenerative Medicine, and Stem Cells in a world renown institute for TERM, exploring magnetic nanocarriers' impact on tendon healing in inflammatory conditions. A substantial part of her PhD was performed in collaboration with the School of Infection and Immunity from University of Glasgow (Scotland, United Kingdom). She is familiar with several biomaterials processing techniques and cell culture methodologies. Also, she is an autonomous operator for (RT-)PCR, histology, and microscopy instruments. She is particularly interested in platforms to predict in vivo responses and in reprograming tools for guided therapies using precision and personalized approaches. She is author of 9 full papers in international refereed journals, 4 communications and 12 participations in national/international conferences. Scientifically, the outcomes of her research have contributed to insights in materials science and cell biology in the musculoskeletal tissue engineering and regenerative medicine field.

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Identification

Personal identification

Full name: Ana Filipa Martins de Almeida

Citation names

Ana Almeida
Ana F. Almeida
A. Almeida

Author identifiers

Ciência ID: 2614-E969-E9A6
ORCID iD: 0000-0001-6663-6851
Researcher Id: AAB-8709-2020

Email addresses

ana.almeida@i3bs.uminho.pt (Professional)

Addresses

Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 , Barco, Guimarães, Portugal (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Advanced (C1)	Proficiency (C2)	Proficiency (C2)

Education

	Degree	Classification
2019/10 - 2023/10 Ongoing	Programa Doutoral em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento) Laboratório Associado ICVS 3B's, Portugal
2018/03/27 Concluded	Genética Molecular (Mestrado) Universidade do Minho, Portugal "The role of oncogenic KRAS in colorectal cancer: from subcellular localization upon autophagy induction to new therapeutic drugs" (THESIS/DISSERTATION)	18
2015/07/07 Concluded	Genética e Biotecnologia (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal "Avaliação de efeitos biológicos do creme Thalion® in vivo em Drosophila melanogaster" (THESIS/DISSERTATION)	15

Affiliation

Science

	Category Host institution	Employer
2018/11/12 - 2019/05/11	Researcher (Research)	Laboratório Associado ICVS 3B's, Portugal

2018/04 - 2018/10	Research Trainee (Research)	Synovo GmbH, Germany
	Synovo GmbH, Germany

Others

	Category Host institution	Employer
2016/09 - 2018/02	Investigador no âmbito da tese de Mestrado	Universidade do Minho Escola de Ciências, Portugal
	Universidade do Minho Escola de Ciências, Portugal

Projects

Grant

	Designation	Funders
2019/09 - 2024/06	Development of magnetically responsive cell-instructive systems to target inflammatory cues underlying tendinopathy SFRH/BD/144816/2019 COVID/BD/153447/2023 PhD Student Fellow	Ongoing

Other

	Designation	Funders
2018/11/12 - 2019/09/30	MagTendon – Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration 772817 Master Student Fellow	Concluded

Outputs

Publications

Conference poster

Margarida S. Miranda; Ana Almeida; Márcia T. Rodrigues; Gomes, Manuela E.. "Hybrid nanovehicles for cell-targeting delivery of distinct therapeutic agents". Paper presented in 31st Annual Meeting of the European Orthopaedic Research Society (EORS 2023), 2023.
Ana Almeida; Margarida S. Miranda; Márcia T. Rodrigues; Manuela E. Gomes. "Multifunctional Magnetic Polymeric Micelles for Targeted Macrophage Modulation and RNA-Based Theranostics". Paper presented in HEALTH-UNORTE Conference, 2023.
Margarida S. Miranda; Ana F. Almeida; Márcia T. Rodrigues; Manuela E. Gomes. "Hybrid nanovehicles for combined drug delivery and cellular reprogramming". Paper presented in REMIX Workshop, 2023.
Ana F. Almeida; Margarida S. Miranda, ; Márcia T. Rodrigues; Manuela E. Gomes. "Precision vehicles for combined targeted drug delivery and cellular reprogramming". Paper presented in TERMIS 2023 EU-chapter, 2023.
Rodrigues, Márcia T.; Ana F. Almeida; Margarida S. Miranda; Manuela E. Gomes. "Untethered Hybrid Nanotechnology Vehicles For RNA-Based Therapeutics To Manage Chronic Inflammation". Paper presented in ORS, 2023.
A. Almeida; M.S. Miranda; A. Vinhas; A.I. Gonçalves; M.T. Rodrigues; M.E. Gomes. "Untethered vehicles for multiple payloads: designing precision tools for targeted drug delivery and cellular programming". Paper presented in Book of Abstracts of the Final Achilles Conference, 2022.
Ana F. Almeida; Margarida S. Miranda; Vinhas, Adriana; Ana I. Gonçalves; Rodrigues, Márcia T.; Manuela E. Gomes. "Contactless miR-based targeting for precision reprograming of macrophage functions". Paper presented in Final Achilles Workshop, 2022.
Ana F. Almeida; Margarida S. Miranda; Adriana Vinhas; Ana I. Gonçalves; Rodrigues, Márcia T.; Manuela E. Gomes. "Contactless modulation of macrophages inflammatory responses using SPIONs-miRNA complexes". Paper presented in 3rd Achilles Workshop, 2021.
Margarida S. Miranda; Ana F. Almeida; Rodrigues, Márcia T.; Manuela E. Gomes. "Fabrication of magnetic micelles for drug delivery and cellular programming aiming at targeted nanotheranostics". Paper presented in 3rd Achilles Workshop, 2021.
Vinhas, Adriana; Ana F. Almeida; Ana Gonçalves; Rodrigues, Márcia T.; Manuela E. Gomes. "Approaching magnetic cell sheets under hypoxic and inflammatory environment to study immunomodulatory potential for tendon therapies". Paper presented in 3rd Achilles Workshop, 2021.
A. Almeida; Margarida S. Miranda; A. Vinhas; A.I. Gonçalves; M.T. Rodrigues; Rui L. Reis; M.E. Gomes. "Modulating macrophage phenotypes via immune-switch magnetic nanoparticles". Paper presented in 31st Conference of the European Society for Biomaterials (ESB2021) and 43rd Annual Congress of the Iberian Society of Biomechanics and Biomaterials (SIBB), Poster presentation, Porto, Portugal, 5-9 September 2021, 2021.
Ana F. Almeida. "Pursuing inflammatory cues in tendinopathy using a magnetically responsive cell-instructive system". Paper presented in Second Achilles Conference and TERMSTEM, 2019.
Vinhas, A.; Rodrigues, Márcia T.; Ana Almeida; Gonçalves, A. I.; Reis, Rui L.; Gomes, Manuela E.. "The interplay between macrophages and tendon cells under magnetic actuation: insights on intercellular communication envisioning tendon regenerative approaches". Paper presented in 2nd Achilles Conference, Braga, 2019.
Ana Almeida; Vinhas, A.; Gonçalves, A. I.; Miranda, Margarida S.; Rodrigues, Márcia T.. "Magnetically responsive cell-instructive systems to target inflammatory cues in tendinopathy". Paper presented in 1st Discoveries Forum on Regenerative and Precision Medicine, Porto, 2019.
"Tendon regeneration strategies using magnetic responsive cell-instructive systems to target inflammatory cues". Paper presented in 1st Discoveries Forum, 2019.
Ana F. Almeida. "Development of magnetically responsive cell-instructive systems to target inflammatory cues in tendinopathy". Paper presented in First Achilles Conference and ForeCaST Workshop, 2019.
Ana F. Almeida. "Unveil the KRAS/Galectin-3/p16INK4a triple axis regulation in colorectal cancer". Paper presented in 25th Porto Cancer Meeting, 2018.

Journal article

Ana F. Almeida; Margarida S. Miranda; Adriana Vinhas; Márcia T. Rodrigues; Manuela E. Gomes. "Contactless Resolution of Inflammatory Signals in Tailored Macrophage-Based Cell Therapeutics". ACS Applied Materials & Interfaces (2023): https://doi.org/10.1021/acsami.2c22505.
10.1021/acsami.2c22505
Vinhas, Adriana; Ana F. Almeida; Rodrigues, Márcia T.; Manuela E. Gomes. "Prospects of magnetically based approaches addressing inflammation in tendon tissues". Advanced Drug Delivery Reviews 196 (2023): https://www.sciencedirect.com/science/article/pii/S0169409X23001308?via%3Dihub.
João C. C. Ferreira; Sara Granja; Ana F. Almeida; Fátima Baltazar; M. Sameiro T. Gonçalves; Ana Preto; Maria João Sousa. "Targeting Lysosomes in Colorectal Cancer: Exploring the Anticancer Activity of a New Benzo[a]phenoxazine Derivative". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms24010614.
10.3390/ijms24010614
Ana F. Almeida; Margarida S. Miranda; Adriana Vinhas; Ana I. Gonçalves; Manuela E. Gomes; Márcia T. Rodrigues. "Controlling Macrophage Polarization to Modulate Inflammatory Cues Using Immune-Switch Nanoparticles". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232315125.
10.3390/ijms232315125
Margarida S. Miranda; Ana F. Almeida; ME Gomes; M. T. Rodrigues. "Magnetic Micellar Nanovehicles: Prospects of Multifunctional Hybrid Systems for Precision Theranostics". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/19/11793.
10.3390/ijms231911793
J. Azevedo-Silva; D. Tavares-Valente; A. Almeida; O. Queirós; F. Baltazar; Y. H. Ko; P. L. Pedersen; A. Preto; M. Casal. "Cytoskeleton disruption by the metabolic inhibitor 3-bromopyruvate: implications in cancer therapy". Medical Oncology (2022):
Published
Ana F. Almeida; Adriana Vinhas; Ana I. Gonçalves; Margarida S. Miranda; Márcia T. Rodrigues; Manuela E. Gomes. "Magnetic triggers in biomedical applications – prospects for contact free cell sensing and guidance". Journal of Materials Chemistry B (2021): https://doi.org/10.1039/D0TB02474K.
10.1039/D0TB02474K
Vinhas, Adriana; Almeida, Ana F.; Gonçalves, Ana I.; Rodrigues, Márcia T.; Gomes, Manuela E.. "Magnetic Stimulation Drives Macrophage Polarization in Cell to–Cell Communication with IL-1ß Primed Tendon Cells". International Journal of Molecular Sciences 21 15 (2020): 5441. http://dx.doi.org/10.3390/ijms21155441.
10.3390/ijms21155441
Cazzanelli, Giulia; Pereira, Flávia; Alves, Sara; Francisco, Rita; Azevedo, Luísa; Dias Carvalho, Patrícia; Almeida, Ana; et al. "The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis". Cells 7 2 (2018): 14. http://dx.doi.org/10.3390/cells7020014.
10.3390/cells7020014

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/09	Precision Magnetoplexes for microRNA Delivery Targeting Tendon Inflammation	31st Annual Meeting of the European Orthopaedic Research Society (EORS 2023) (Porto, Portugal)
2022/06	Modulating macrophage phenotypes via immune-switch magnetic nanoparticles	TERMIS 2022 EU-chapter (Krakow, Poland)
2022/06	Magnetically miRNA-based guidance of macrophage functions	TERMIS 2022 EU - CHAPTER (Krakow, Poland)
2021/10	IL4-decorated SPIONs contribute to immunoregulatory actions on macrophages via IL4/STAT6	3rd Achilles Workshop (Porto, Portugal)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/09/27 - 2023/09/29	Membro da Comissão Organizadora da "31st Annual Meeting of the European Orthopaedic Research Society (EORS) " (2023/09/27 - 2023/09/29) Congress (Member of the Organising Committee)
2022/05/25 - 2022/05/27	Membro da Comissão Organizadora da "Final Achilles Conference" (2022/05/25 - 2022/05/27) Conference (Member of the Organising Committee)
2021/10/25 - 2021/10/27	Membro da comissão Organizadora da "3rd Achilles Conference" (2021/10/25 - 2021/10/27) Conference (Member of the Organising Committee)