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Clara M. Bento obtained a Bachelor's and a Master's degree in Biochemistry from the University of Porto in 2017 and 2019, respectively. Her Master's thesis studies focused on assessing the potential of ionic liquids as new antimicrobial compounds against Mycobacterium avium. Clara M. Bento worked as an Invited Assistant Professor at Escola Superior de Saúde, Instituto Politécnico do Porto and continued teaching Microbiology as Invited Assistant Professor at Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto. In January 2021, Clara M. Bento started her PhD studies in the Doctoral Program in Molecular and Cell Biology at the Host Targets of Infection group at i35, under the supervision of Tânia Silva and Salomé Gomes, developing new in vitro models to study drug susceptibility against mycobacteria, including organoid and biofilm models. Clara M. Bento has been a member of 5 funded national and international projects with 7 peer-reviewed articles in these areas.
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Identification

Personal identification

Full name
Clara Milhazes Bento

Citation names

  • Bento, Clara M.

Author identifiers

Ciência ID
2615-B7B2-0171
ORCID iD
0000-0001-9019-7334
Scopus Author Id
57212654946

Email addresses

  • clarambento96@gmail.com (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2)
Education
Degree Classification
2021 - 2024
Ongoing
 Doctoral Program in Molecular and Cell Biology (Doutoramento)
Universidade do Porto, Portugal
2023/03/01 - 2023/03/31
Ongoing
 Short-term internship: Establishment of co-cultures of primary eukaryotic cells (Outros)
Julius-Maximilians-Universität Würzburg Institut für Molekulare Infektionsbiologie, Germany
2022/05/09 - 2022/05/20
Concluded
 Laboratory Animal Science Course | FELASA accredited course for functions A, B and D (mouse, rat, zebrafish and fish species-specific) aligned with the European Directive 2010/63 (Diploma de especialização)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/10/01 - 2019/12/20
Concluded
 ERASMUS+ Internship (Postgraduate Certificate)
Universiteit Antwerpen Laboratory for Microbiology Parasitology and Hygiene, Belgium
2017/09 - 2019/09
Concluded
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Evaluation of the effects of selected ionic liquids against Mycobacterium avium." (THESIS/DISSERTATION)
 18
2018/06 - 2018/08
Concluded
 Introductory Course in Laboratory Animal Science under the EU directive 2010/63/EU. Functions (A) and (D): Mice and Rats species specific (Diploma de especialização)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/09 - 2017/07
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Impact of dietary habits on circulating leukocytes in multiple sclerosis." (THESIS/DISSERTATION)
 16
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2023/02 - Current Invited Assistant (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01 - 2021/09 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2021/01/01 - Current PhD candidate Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/07 - 2019/07 Monitor Junior University Universidade do Porto, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/07 - 2018/07 Monitor Junior University Universidade do Porto, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Grant

Designation Funders
2021 - Current NTM: New Tools against nontuberculous Mycobacteria
UI/BD/150830/2021
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2021/04 - Current MycoPepTalking - Refining Antimicrobial Peptides with cutting-edge strategies to tackle infections by Nontuberculous Mycobacteria
PTDC/BIA-MIC/3458/2020
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2024/01/01 - 2024/09/11 IronCell2Cell - The macrophage-hepatocyte iron communication during mycobacterial infection
2022.03635.PTDC
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01 - 2023/04 REMODEL - Research models in infection, cancer and regeneration: replacement and translation
857491
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universiteit Utrecht, Netherlands

Kobenhavns Universitet Institut for Cellular og Molekylar Medicin, Denmark

Julius-Maximilians-Universität Würzburg, Germany
European Union
Concluded
2019/04 - 2022/01 Two4Three - A small couple against the big three
PTDC/BTM-SAL/29786/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020 - 2021 Ironing COVID-19 - Finding in the host iron status the signature to predict the severity of the disease
Research4COVID - grant 569
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Bento, Clara M.; Kevin Van Calster; Tatiana Piller; Oliveira, Gabriel S.; Gonçalves, Rute; Linda De Vooght; Davie Cappoen; et al. "Mycobacterium abscessus double-reporter strains: new tools to fight mycobacterial infections". Paper presented in The 2nd International Electronic Conference on Microbiology, 2023.
    Published
  2. Almeida, Joana; Pereira, Cassilda; Coelho, Pedro; Teixeira, Dulce; Louçano, Marta; Bento, Clara M.; Cerqueira, MJ; et al. "Biotechnology and Biochemistry laboratorial education through the SARS-CoV2 pandemic: challenges, truths and takeaways". Paper presented in IUBMB-FEBS-PABMB 2022 Congress: 'The Biochemistry Global Summit, Lisbon, 2022.
    Published • https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13440
  3. Bento, Clara M.; Silva, Tânia; Aguiar, Luísa; Teixeira, Cátia; Gomes, Paula; Ferraz, Ricardo; Gomes, Maria Salomé. "Repurposing conventional antimycobacterial drugs using ionic liquids". Paper presented in ECMC 2021 7th Edition, 2021.
    10.3390/ecmc2021-11535
  4. Bento, Clara M.; Silva, Tânia; Aguiar, Luísa; Teixeira, Cátia; Gomes, Paula; Ricardo Ferraz; Gomes, Maria Salomé. "Ionic liquids on the rescuing of conventional antimycobacterial drugs". Paper presented in IV International Caparica Conference in Antibiotic Resistance (IC2AR 2021), Caparica, 2021.
    Published • 10.5584/jiomics.v11i1.200
Conference poster
  1. Bento, Clara M.; Lisa Geerts; Jorge Gabriel de Sousa Oliveira; Gomes, Maria Salomé; Silva, Tânia. "The response of macrophages to infection is dependent on mycobacterial growth phase". Paper presented in 48th Congress of the Federation of European Biochemical Societies, Allianz MiCo – Milano Convention Centre, Milan, Italy, 2024.
    10.1002/2211-5463.13837
  2. Jorge Gabriel de Sousa Oliveira; Bento, Clara M.; Pombinho, António; Rita M. Reis; Kevin Van Calster; Linda De Vooght; Maia, André; Gomes, Maria Salomé; Silva, Tânia. "Mycobacterium abscessus double reporter strain as a readout of therapeutic efficacy – high-throughput screening development and validation". Paper presented in 6th Meeting on Medicinal Biotechnology, Escola Superior de Saúde do Instituto Politécnico do Porto, 2024.
  3. Bento, Clara M.; Jorge Gabriel de Sousa Oliveira; Lisa Geerts; Gomes, Maria Salomé; Silva, Tânia. "M&Ms – The dependence of bacterial growth phase on Mycobacterium-Macrophage interaction". Paper presented in 44th Annual Congress of the European Society of Mycobacteriology, Old St. John Congress and Event Centre, Bruges, Belgium, 2024.
  4. Jorge Gabriel de Sousa Oliveira; Bento, Clara M.; Pombinho, António; Rita M. Reis; Kevin Van Calster; Linda De Vooght; Maia, André; et al. "Mycobacterium abscessus double reporter strain as a readout of therapeutic efficacy – high-throughput screening development and validation". Paper presented in SLAS Europe 2024 Conference and Exhibition, Barcelona, Spain, 2024.
  5. Bento, Clara M.; Kevin Van Calster; Tatiana Piller; Oliveira, Gabriel S.; Davie Cappoen; Linda De Vooght; Paul Cos; Gomes, Maria Salomé; Tânia Martins da Silva (001E-1B3C-C38D). "New tools for drug susceptibility testing against non-tuberculous mycobacteria". Paper presented in Brilliant PhDs, brighter future: Shaping Science together, 2023.
  6. Bento, Clara M.; Calster, K. V.; Piller, T.; Oliveira, Gabriel S.; Vooght, L. D.; Cappoen, D.; Cos, P.; Gomes, Maria Salomé; Silva, Tânia. Corresponding author: Silva, Tânia. "Characterization of novel double-reporter strains of Mycobacterium abscessus for drug discovery: A study in mScarlet". Paper presented in 43rd Annual Meeting of the European Society of Mycobacteriology, 2023.
  7. Bento, Clara M.; Marta Silva; Anna Olsson; Gomes, Maria Salomé; Silva, Tânia. "Infection of lung organoids to study mycobacterial drug susceptibility". Paper presented in 9th Ed Molecular and Cell Biology Symposium, 2023.
  8. Bento, Clara M.; Silva, Tânia; Aguiar, Luísa; Teixeira, Catia; Gomes, Paula; Ferraz, Ricardo; Gomes, Maria Salomé. "New ionic liquids to treat mycobacterial infection". Paper presented in EMBO Workshop on Tuberculosis, 2022.
  9. Bento, Clara M.; Gomes, Maria Salomé; Silva, Tânia. "New infection models to test drugs against nontuberculous mycobacteria". Paper presented in MICROBIOTEC21 Congress of Microbiology and Biotechnology, 2021.
  10. Bento, Clara M.; Kevin Van Calster; Paul Cos; Gomes, Maria Salomé; Davie Cappoen. "Construction of a double-reporter strain to assist drug screening against mycobacteria". Paper presented in IJUP 2020 - Encontro de Investigação Jovem, 2020.
  11. Moreira, Ana C.; Silva, Tânia; Gonçalo Mesquita; Ana C. Gomes; Bento, Clara M.; Agostinho Almeida; Gomes, Maria Salomé. "The Double face of H-ferritin in mycobacterial infections". Paper presented in MycoPORTO - MycoNET Meeting, 2019.
  12. Bento, Clara M.; Silva, Tânia; Moreira, Ana C.; Teixeira, Catia; Ferraz, Ricardo; Prudêncio, Cristina; Gomes, Paula; Gomes, Maria Salomé. "Effect of ionic liquids against Mycobacterium avium". Paper presented in MycoPORTO - MycoNET Meeting, 2019.
Journal article
  1. Clara M. Bento; Kevin van Calster; Tatiana Piller; Gabriel S. Oliveira; Linda de Vooght; Davie Cappoen; Paul Cos; M. Salomé Gomes; Tânia Silva. "Characterization of novel double-reporter strains of Mycobacterium abscessus for drug discovery: a study in mScarlet". Microbiology Spectrum (2024): https://doi.org/10.1128/spectrum.00362-24.
    10.1128/spectrum.00362-24
  2. Clara M. Bento; Ana Teresa Silva; Bruno Mansano; Luísa Aguiar; Cátia Teixeira; Maria Salomé Gomes; Paula Gomes; Tânia Silva; Ricardo Ferraz. "Improving the Antimycobacterial Drug Clofazimine through Formation of Organic Salts by Combination with Fluoroquinolones". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24021402.
    10.3390/ijms24021402
  3. Ana C. Moreira; Tânia Silva; Gonçalo Mesquita; Ana Cordeiro Gomes; Clara M. Bento; João V. Neves; Daniela F. Rodrigues; et al. "H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms23010269.
    10.3390/ijms23010269
  4. Ana C. Moreira; Maria Jose Teles; Tânia Silva; Clara M. Bento; Inês Simões Alves; Luisa Pereira; João Tiago Guimarães; et al. "Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection". Viruses (2021): https://doi.org/10.3390/v13122482.
    10.3390/v13122482
  5. Clara M. Bento; Maria Salomé Gomes; Tânia Silva. "Evolution of Antibacterial Drug Screening Methods: Current Prospects for Mycobacteria". Microorganisms (2021): https://doi.org/10.3390/microorganisms9122562.
    10.3390/microorganisms9122562
  6. Clara M. Bento; Tânia Silva; Luísa Aguiar; Cátia Teixeira; Paula Gomes; Ricardo Ferraz; Maria Salomé Gomes. "Preliminary Communication: Ionic liquids on the rescuing of conventional antimycobacterial drugs". Journal of Integrated Omics 11 1 (2021): 24-25.
    Open access • Published
  7. Clara M. Bento; Maria Salomé Gomes; Tânia Silva. "Looking beyond Typical Treatments for Atypical Mycobacteria". Antibiotics 9 1 (2020): 18-18. https://doi.org/10.3390/antibiotics9010018.
    Published • 10.3390/antibiotics9010018
  8. Ana Teresa Silva; Clara M. Bento; Ana C. Pena; Luísa M. Figueiredo; Cristina Prudêncio; Luísa Aguiar; Tânia Silva; et al. "Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs". Molecules 25 66 (2019): https://www.mdpi.com/1420-3049/25/1/66.
    Published • 10.3390/molecules25010066
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06 Enhancing drug discovery against Mycobacterium abscessus: high-throughput screenings to tackle antimicrobial resistance OneHealth PhD Forum
Instituto de Ciências Biomédicas Abel Salazar (ICBAS) (Porto, Portugal)
2024/04/18 Development of complex in vitro models of mycobacterial infection for drug screening 10th Molecular and Cell Biology Symposium - A decade building science
Instituto de Investigação e Inovação em Saúde (i3S) (Porto, Portugal)
2023/11/17 New tools for drug susceptibility testing against non-tuberculous mycobacteria 10th i3S Annual Meeting
Instituto de Investigação e Inovação em Saúde, Universidade do Porto (Póvoa de Varzim, Portugal)
2023/05/11 Development and characterization of mycobacterial biofilm models to study drug susceptibility IJUP 2023 - Encontro de Investigação Jovem da Universidade do Porto
Universidade do Porto (Porto, Portugal)
2022/09/21 Lung organoids for the development of drugs against mycobacterial infections REMODEL Summer School: Next-Generation Organoids and organ-on-chip
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal (Porto, Portugal)
2021/12/20 Use of Ionic Liquids to Fight Mycobacteria Colóquio "A Small Couple Against the Big Three"
Escola Superior de Saúde do Instituto Politécnico do Porto (Porto, Portugal)
2021/06/16 Ionic liquids on the rescuing of conventional antimycobacterial drugs 4th International Caparica Conference in Antibiotic Resistance (IC2AR 2021)
BIOSCOPE Research Group | PROTEOMASS Scientific Society (Portugal)
2020/01/31 Role of ferritin in resistance to mycobacterial infection - studies in the mouse model II Simpósio de Investigação em Tuberculose e Micobactérias Não Tuberculosas em Portugal
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2019/09/11 Ciência e Sociedade: explorando colaborações em contexto formativo IV Conferência Rumos da Sociologia do Conhecimento, Ciência e Tecnologia em Portugal
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (Porto, Portugal)
2019/02/13 Antimycobacterial effect of selected chloroquine-based ionic liquids IJUP 2019 - Encontro de Investigação Jovem
Universidade do Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09/01 - 2023/07/17 Characterization of mycobacterial biofilm models to study drug susceptibility
Co-supervisor of Mariana Magalhães Ribeiro
 Bioquímica (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/03/04 - 2022/03/04 8th edition of the Molecular and Cell Biology Symposium - "Let's have a moment of science!" (2022/03/04 - 2022/03/04)
Symposium (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/11/17 - 2017/11/17 Resistência a antibióticos. Diálogo Ciência-Sociedade e o Futuro - Ensaiando cenários (2017/11/17 - 2017/11/17)
Conference (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/12/04 - 2023/12/05 Course: Workshop on Scientific Writing: How to streamline the process of writing a scientific paper
Workshop
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/11/06 - 2023/11/08 Course: 3D microscopy imaging with clearness
Workshop
 3D microscopy imaging with clearness, 1st edition
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09/25 - 2023/09/29 Course: 5th International Practical Biofilm Course and Symposium
Workshop
 5th International Practical Biofilm Course and Symposium
Universidade do Minho Departamento de Engenharia Biológica, Portugal
2022/10 - 2022/10 Online course: Pulmonary On-Demand Training Course presented by StemCell Technologies Pulmonary On-Demand Training Course
STEMCELL Technologies Inc, Canada
2022/07/04 - 2022/07/08 Utrecht Summer School - Advanced In Vitro Models, Utrecht University, The Netherlands
Workshop
Universiteit Utrecht, Netherlands
2022/07/05 - 2022/07/06 Organ-on-a-chip Master Class by AZAR Innovations, Utrecht University, The Netherlands
Workshop
Universiteit Utrecht, Netherlands
2022/06/28 - 2022/06/28 Attendance: 9th BiotechHealth Annual Symposium: Resilient Science in a Changing World
Symposium
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/04/26 - 2022/04/29 Course: Advanced Course on Organoid Models | 1st Edition
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09/08 - 2021/09/09 Participation in the INTEGRITY European Student Convention 2021
Meeting
 INTEGRITY European Student Convention 2021, online event
2021/07/05 - 2021/07/09 Course: Organoids systems for the study of infection | 1st edition
Workshop
 Organoids systems for the study of infection | 1st edition
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

University of Wuerzburg, Germany
2021/05/25 - 2021/05/27 Online course: BioImage Analysis for High Content Screening (ImageJ/Fiji, Cell Profiler/Cell Profiler Analyst)
Workshop
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/10/06 - 2020/10/09 Course: Organoids and Advanced 3D in Vitro Models for Research in Health and Disease
Workshop
 Workshop: Organoids and Advanced 3D in Vitro Models for Research in Health and Disease
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Association member

Society Organization name Role
2024/03 - Current Sociedade Portuguesa de Bioquímica
2021/10 - Current Sociedade Portuguesa de Microbiologia

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/02 - Current Microbiologia Geral Medicina Veterinária (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/04/11 - 2023/04/14 Advanced Course on Organoids Models | 3rd Edition Advanced Course on Organoid Models, 3rd Edition (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/11/21 - 2022/11/25 Advanced Course on Organoid Models | 2nd Edition Advanced Course on Organoid Models, 2nd Edition (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/02 - 2020/07 Microbial Biochemistry Biotecnologia Medicinal (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/02 - 2020/07 Biochemistry Farmácia (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/01 - 2020/03 Biochemistry Laboratórios de Química e Bioquímica (Curso Técnico Superior Profissional) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/01 - 2020/03 Laboratorial Techniques of Chemistry Laboratórios de Química e Bioquímica (Curso Técnico Superior Profissional) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Mentoring / Tutoring

Topic Student name
2023/09 - 2024/01 Exploring the relationship between mycobacterial growth phase and macrophage infection Lisa Geerts
2022/09 - 2023/01 Cooperation agreement - Studies between Portugal and Brazil Juliana Fujikura
2022/02 - 2022/07 Actinobacteria might hold the answer: searching for new therapeutic agents in the microbial world, FCUP/ICBAS Nuno Duarte Pereira Pinto
2021/07 - 2021/07 Extracurricular Internship Program on Pharmaceutical Sciences, FFUP Tiago Miguel Brochado Teixeira
2019/04 - 2019/07 Desenvolvimento de novas terapias contra infeções por micobactérias, Escola Superior de Saúde do IPP Daniela Carina Oliveira da Silva