Alexandre José Neto Trindade (271C-3493-6F91)

Curriculum Vitae

Alexandre José Neto Trindade

Alexandre Trindade (AT) graduated in Microbiology and Genetics from the Sciences Faculty of the University of Lisbon (UL) in 2002 and completed a PhD degree in Animal Sciences and Technology from the Veterinary Medicine Faculty (FMV-UL) of the Technical University of Lisbon in 2008. AT has developed and produced four new mutant mouse lines. These new tools have been instrumental in growing the knowledge of Notch signalling function in various systems, from embryogenesis to cancer. AT was one of the 50 international researchers selected to participate in the first São Paulo School of Translational Science. AT was a post-doctoral researcher at the Centre for Interdisciplinary Research in Animal Health (CIISA) from 2009 until 2021. In that time, AT participated in 17 research projects, having been PI of seven and co-supervisor of two PhD students, and performed various contracted pre-clinical trials in a vivarium setting. The interest in pre-clinical research also led to undergoing postgraduate training in clinical trials at the Medical Faculty (UL). In 2019, he was nominated as a member of the Welfare and Ethics Committee of FMV-UL and elected to the CIISA Coordination Commission. In 2021, AT was recruited for an Assistant Professor position at Egas Moniz. In 2021, AT was elected to the Portuguese Society for Veterinary Sciences (SPCV) Direction. In 2022, AT won the position of Associate Professor at Egas Moniz School of Health & Science, and a year later, he became the coordinator of a new Degree in Biomedical Sciences. AT has been a member of the Egas Moniz Center for Interdisciplinary Research (CiiEM) since 2021 and part of the new Board of CiiEM since 2023. AT is the Head of the Research Group entitled Technologies and Solutions in Healthcare at CiiEM. AT is now the internal PI of project InFishMix, funded by EEA Grants and PI of work package task InBio2 of the InsectERA Mobilizing Agenda, funded by PRR, and supervises two PhD students.

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Identification

Personal identification

Full name: Alexandre José Neto Trindade

Citation names

Trindade, Alexandre

Author identifiers

Ciência ID: 271C-3493-6F91
ORCID iD: 0000-0002-3104-9259
Google Scholar ID: x96p1oUAAAAJ&hl
Researcher Id: AAC-9726-2019
Scopus Author Id: 56432456900

Email addresses

atrindade@egasmoniz.edu.pt (Professional)

Telephones

Mobile phone

967276762 (Personal)

Addresses

Rua Dom João de Castro Nº15 - 2ºDto, 1300-188, Lisboa, Lisboa, Portugal (Personal)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
Medical and Health Sciences - Basic Medicine - Physiology
Natural sciences - Biological Sciences - Reproductive Biology
Natural sciences - Biological Sciences - Developmental Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2002/01/01 - 2008/12/08 Concluded	Animal Science and Technology (Doutoramento) Major in Animal Science and Technology Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal "Analysis on the function of Delta4 in the regulation of embryonic angiogenesis and tumoral neo-angiogenesis" (THESIS/DISSERTATION)	Unanimous approval
1997 - 2002 Concluded	Biologia Microbiana e Genética (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal "Production of a transgenic mouse line conditionally overexpressing mdelta4" (THESIS/DISSERTATION)	16

Affiliation

Science

	Category Host institution	Employer
2024/01/01 - Current	Coordinating Researcher (Research)	Centro de Investigação Interdisciplinar Egas Moniz, Portugal
	Centro de Investigação Interdisciplinar Egas Moniz, Portugal
2019/02/01 - 2021/08/31	Auxiliary Researcher (Research)	Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2022/10/01 - Current	Associate Professor (University Teacher)	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2021/09/01 - 2022/09/30	Assistant Professor (University Teacher)	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal

Others

	Category Host institution	Employer
2015/10/01 - 2019/01/31	Post-Doctoral Researcher - SFRH/BPD/110174/2015 - Notch3 function in oncology recapitulates ontogeny and represents a potential therapeutic target for prostate cancer	Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

2009/01/01 - 2014/12/31	Post-Doctoral Researcher - SFRH/BPD/47079/2008 - Evaluation of the importance of anti-Dll4 therapy in a murine model of prostate cancer	Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

2002/11/01 - 2008/12/17	PhD Student - SFRH/BD/9006/2002 - Analysis of Dll4 function in the regulation of embryonic angiogenesis and tumoral neo-angiogenesis	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Projects

Grant

	Designation	Funders
2023/03/30 - Current	GreenSoldierFly \| Study of embryonic development of BSF larvae to optimize transgenesis design GreenSoldierFly Researcher Centro de Investigação Interdisciplinar Egas Moniz, Portugal	Centro de Investigação Interdisciplinar Egas Moniz Ongoing
2022/11 - Current	InsectERA \| A ERA da indústria dos insetos InsectERA Researcher Centro de Investigação Interdisciplinar Egas Moniz, Portugal	Agência para a Competitividade e Inovação IP Ongoing
2022/10/14 - Current	COST Action - CA22140 - Insect-IMP - Improved Knowledge Transfer for Sustainable Insect Breeding OC-2022-1-26007 Researcher Centro de Investigação Interdisciplinar Egas Moniz, Portugal	European Cooperation in Science and Technology Submitted
2022/05 - Current	InFishMix 218/DSP/2022 Co-Principal Investigator (Co-PI) Centro de Investigação Interdisciplinar Egas Moniz, Portugal	EEA Grants Ongoing
2022/03 - Current	FlyWaste \| Insect as a tool in urban waste recovery FlyWaste Researcher Centro de Investigação Interdisciplinar Egas Moniz, Portugal	Centro de Investigação Interdisciplinar Egas Moniz Ongoing
2014/03 - 2015/03	Notch-Wnt signaling cross-talk in the regulation of pre-implantation embryo development Provided by PTCRIS: 135314 135314	Fundação para a Ciência e a Tecnologia, I.P.
2012/01 - 2014/12	Investigation on the effect of Dll4Fc anti-angiogenic tumour therapy on metastatic dissemination 121742 Provided by PTCRIS: 121742	Fundação para a Ciência e a Tecnologia, I.P.
2011/05 - 2014/05	Characterization of the Jagged1 ligand endothelial role in the regulation of tumoral neo-angiogenesis Provided by PTCRIS: 116164 116164	Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2009/06	Arteriogenesis: indentification of new members of the Notch patway involved in arterial cell fate determination 82490 Provided by PTCRIS: 82490	Fundação para a Ciência e a Tecnologia, I.P.
2005/07 - 2007/12	Arteriogenesis: indentification of new members of the Notch patway involved in arterial cell fate determination 56015 Provided by PTCRIS: 56015	Fundação para a Ciência e a Tecnologia, I.P.

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Laboratório Associado para Ciência Animal e Veterinária 10.54499/LA/P/0059/2020 Universidade de Trás-os-Montes e Alto Douro, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Ciência Animal e Veterinária, Portugal Universidade do Porto Centro de Estudos de Ciencia Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	Programming the type and localization of adaptive immunity by targeting TLR2: a strategy for the development of novel veterinary vaccines PTDC/CVT-CVT/31840/2017 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/09/01 - 2021/08/31	Polyphasic validation of antimicrobial peptides as alternative treatment for diabetic foot infections PTDC/SAU-INF/28466/2017 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/01/01 - 2020/12/31	POINT4PAC - Precision Oncology by Innovative Therapies and Technologies SAICTPAC/0019/2015 Researcher Universidade de Lisboa Faculdade de Farmácia, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal INESC Microsistemas e Nanotecnologias, Portugal Instituto Politécnico de Leiria, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	Centro de Investigação Interdisciplinar em Sanidade Animal UID/CVT/00276/2019 Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/03/14 - 2015/09/13	Notch-Wnt signaling cross-talk in the regulation of pre-implantation embryo development info:eu-repo/grantAgreement/FCT/3599-PPCDT/135314/PT Researcher Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/01/01 - 2015/06/30	Investigation on the effect of Dll4Fc anti-angiogenic tumour therapy on metastatic dissemination info:eu-repo/grantAgreement/FCT/3599-PPCDT/121742/PT Principal investigator Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Fundação Calouste Gulbenkian, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/05/20 - 2014/11/19	Characterization of the Jagged1 ligand endothelial role in the regulation of tumoral neo-angiogenesis info:eu-repo/grantAgreement/FCT/3599-PPCDT/116164/PT Principal investigator Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Fundação Calouste Gulbenkian, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2013/12/31	Strategic Project - UI 276 - 2011-2012 PEst-OE/AGR/UI0276/2011 Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/18 - 2012	Characterization of the role of a novel anti-angiogenic biopharmaceutical, Dll4-Fc, in the control of tumour growth in animal models info:eu-repo/grantAgreement/FCT/3599-PPCDT/115703/PT Researcher Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2011	The Notch-Delta signalling pathway in the reproductive function of the mouse and cow info:eu-repo/grantAgreement/FCT/3599-PPCDT/105022/PT Researcher Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2011	Angiogenesis in atherosclerotic lesions: function and potential therapeutic application of the Dll4-Notch signaling pathway info:eu-repo/grantAgreement/FCT/3599-PPCDT/102468/PT Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Instituto Gulbenkian de Ciência, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/07/01 - 2007/12/31	Diferenciação arterial: identificação de novos elementos da via Notch determinantes do fenótipo arterial POCI/CVT/56015/2004 Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Fundação Calouste Gulbenkian, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2002 - 2005	Use of transgenic conditional overexpression to address the function of a novel delta homologue, mDll4 POCTI/CVT/48766/2002 Researcher Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Alexandre Trindade. "Immunolocalization of Notch Signaling in Mouse Preimplantation Embryos". 173-185. Springer {US, 2022. 10.1007/978-1-0716-2201-8_14 Murta, D.; Silva, E.; Trindade, A.; Henrique, D.; Duarte, A.; Lopes-da-Costa, L.. "Unraveling Notch Signaling in Reproductive Biology". In Advances in Animal Health, Medicine and Production, 389-402. Springer International Publishing, 2020. Published • 10.1007/978-3-030-61981-7_21 Trindade, A.; Djokovic, D.; Mendonça, L.; Badenes, M.; Lopes-da-Costa, L.; Duarte, A.. "Endothelial Dll4/Notch Signaling as a Target for Cancer and Wound Healing Therapy". In Advances in Animal Health, Medicine and Production, 403-418. Springer International Publishing, 2020. Published • 10.1007/978-3-030-61981-7_22 Pedrosa, A.-R.; Trindade, A.; Duarte, A.. "Methods to study angiogenesis in a mouse model of prostate cancer". 29-54. 2018. 10.1007/978-1-4939-7845-8_2
Conference abstract	Pedro Rodrigues; Marta Afonso; AL Simão; Catarina Carvalho; Alexandre Trindade; António Duarte; Pedro Borralho; et al. "miR-21 ablation and obeticholic acid ameliorate NASH in mice.". Paper presented in The International Liver Congress 2017 — 52nd Annual meeting of the European Association for the Study of the Liver, Amsterdam, 2017. Accepted • 10.1016/S0168-8278(17)31639-2
Conference poster	Alexandre Trindade; Liliana Mendonça; Catarina Carvalho; Jorge Correia; Marina Badenes; Joana Gigante; António Duarte. "Endothelial Dll4 is a multifactorial regulator of tumor metastization". Paper presented in EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, 2020. Alexandre Trindade; Liliana Mendonça; Catarina Carvalho; Jorge Correia; Marina Badenes; Joana Gigante; António Duarte. "Endothelial Dll4 loss-of-function reduces metastasis through multiple mechanisms". Paper presented in 2nd EACR-MRS Conference on Seed and Soil: Mechanisms of Metastasis, 2019. Liliana Mendonça; Alexandre Trindade; Catarina Carvalho; Jorge Correia; Marina Badenes; Joana Gigante; António Duarte. "Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumour cells.". Paper presented in ESMO, 2019. Liliana Mendonça; Alexandre Trindade; Catarina Carvalho; Marina Badenes; Joana Gigante; António Duarte. "Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition, reduction of cancer stem cells and tumour cell intravasation". Paper presented in Exploring the boundaries of animal, veterinary and biomedical sciences. CIISA Congress 2018, 2018. Daniel Murta; Marta Batista; Elisabete Silva; Alexandre Trindade; António Duarte; Luís Lopes da Costa. "Sperm motility is regulated by Notch signaling in the epididymal epithelium.". Paper presented in 20th Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) and the 13th Conference of the Spanish Association for Animal Reproduction (AERA), 2016. Pedro Rodrigues; Marta Afonso; AL Simão; M Caridade; Catarina Carvalho; Alexandre Trindade; António Duarte; et al. "MIR-21 Inhibition and Obeticholic Acid Ameliorate Non-Alcoholic Steatohepatitis in Dietary Animal Models.". Paper presented in The International Liver Congress 2017, 2016. Pedro Rodrigues; Marta Afonso; AL Simão; M Caridade; Catarina Carvalho; Alexandre Trindade; António Duarte; et al. "Dual targeting of nuclear receptors ameliorates NAFLD pathogenesis in mice.". Paper presented in The AASLD Liver Meeting, 2015. Pedro Rodrigues; Marta Afonso; AL Simão; M Caridade; Catarina Carvalho; Alexandre Trindade; António Duarte; et al. "MIR-21 inhibition and FXR activation synergistically ameliorate disease pathogenesis in a mouse model of NAFLD". Paper presented in The International Liver Congress, 2015. António Duarte; Rita pedrosa; Alexandre Trindade; Catarina Carvalho; José Graça; Sandra Carvalho; Maria Conceição Peleteiro; Ralf Adams. "Endothelial-specific Jagged1 blockade prevents solid tumor growth in pre-clinical models". Paper presented in AACR 106th Annual Meeting, 2015. Alexandre Trindade; Rita pedrosa; Ana Fernandes; Valerie Krasnoperov; Ren Liu; Parkash S. Gill; António Duarte. "Dll4Fc concurrent systemic therapy improves tumor drug delivery with considerable gain of therapeutic efficacy". Paper presented in 1st ASPIC International Congress, 2014. Rita pedrosa; Alexandre Trindade; Catarina Carvalho; José Graça; Sandra Carvalho; Maria Conceição Peleteiro; Ralf Adams; António Duarte. "Endothelial Jagged1 regulates tumour perfusion and growth in a murine model of prostate adenocarcinoma (TRAMP)". Paper presented in Vascular Biology 2014, 2014. Liliana Mendonça; Catarina Carvalho; Joana Gigante; Alexandre Trindade; António Duarte. "Paradoxical effect of Dll4 function blockage in tumour metastasis". Paper presented in Vascular Biology 2014, 2014. Rita pedrosa; Alexandre Trindade; Ana Carina Fernandes; Catarina Carvalho; Joana Gigante; António Duarte. "Endothelial Jagged1 antagonizes Dll4 signaling through Notch1 and activates Notch4 in the growing vasculature". Paper presented in Vascular Biology 2013, 2013. Rita pedrosa; Alexandre Trindade; Catarina Carvalho; Ana Carina Fernandes; Ralf Adams; António Duarte. "The role of Jagged1 in physiological angiogenesis". Paper presented in EMBO Young Scientists’ Forum, 2013. Catarina Carvalho; Alexandre Trindade; Rita pedrosa; Ana Carina Fernandes; Valerie Krasnoperov; Ren Liu; Parkash S. Gill; António Duarte. "DLL4FC concurrent systemic therapy is highly efficacious in the treatment of prostate adenocarcinoma". Paper presented in EMBO Young Scientists’ Forum, 2013.
Journal article	Serrano, Isa; Alhinho, Bernardo; Cunha, Eva; Tavares, Luís; Trindade, Alexandre; Oliveira, Manuela. "Bacteriostatic and Antibiofilm Efficacy of a Nisin Z Solution against Co-Cultures of Staphylococcus aureus and Pseudomonas aeruginosa from Diabetic Foot Infections". Life 13 2 (2023): 504. http://dx.doi.org/10.3390/life13020504. 10.3390/life13020504 Alexandre Trindade; António Duarte. "Notch Signaling Function in the Angiocrine Regulation of Tumor Development". Cells 9 11 (2020): 2467-2467. https://doi.org/10.3390/cells9112467. 10.3390/cells9112467 Rui Silva Soares; Raquel Santos; Eva Cunha; Luís Tavares; Alexandre Trindade; Manuela Oliveira. "Influence of Storage on the Antimicrobial and Cytotoxic Activities of a Nisin-biogel with Potential to be Applied to Diabetic Foot Infections Treatment". Antibiotics 9 11 (2020): 781-781. https://doi.org/10.3390/antibiotics9110781. 10.3390/antibiotics9110781 Mendonça, L.; Trindade, A.; Carvalho, C.; Correia, J.; Badenes, M.; Gigante, J.; Duarte, A.. "Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumor cells". Clinical and Experimental Metastasis 36 4 (2019): 365-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066139441&partnerID=MN8TOARS. 10.1007/s10585-019-09973-2 Rodrigues PM; Afonso MB; Simão AL; Carvalho CC; Trindade A; Duarte A; Borralho PM; et al. "miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice.". (2017): http://europepmc.org/abstract/med/28406477. 10.1038/cddis.2017.172 Trindade A; Djokovic D; Gigante J; Mendonça L; Duarte A. "Endothelial Dll4 overexpression reduces vascular response and inhibits tumor growth and metastasization in vivo.". (2017): http://europepmc.org/abstract/med/28288569. 10.1186/s12885-017-3171-2 Badenes M; Trindade A; Pissarra H; Lopes-da-Costa L; Duarte A. "Erratum to: Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms.". (2017): http://europepmc.org/abstract/med/28327101. 10.1186/s12885-017-3202-z Badenes M; Trindade A; Pissarra H; Lopes-da-Costa L; Duarte A. "Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms.". (2017): http://europepmc.org/abstract/med/28086833. 10.1186/s12885-016-3036-0 Murta D; Batista M; Silva E; Trindade A; Henrique D; Duarte A; Lopes-da-Costa L. "Notch signaling in the epididymal epithelium regulates sperm motility and is transferred at a distance within epididymosomes.". (2016): http://europepmc.org/abstract/med/26825631. 10.1111/andr.12144 Pedrosa AR; Graça JL; Carvalho S; Peleteiro MC; Duarte A; Trindade A. "Notch signaling dynamics in the adult healthy prostate and in prostatic tumor development.". (2016): http://europepmc.org/abstract/med/26419726. 10.1002/pros.23102 Pedrosa AR; Trindade A; Carvalho C; Graça J; Carvalho S; Peleteiro MC; Adams RH; et al. "Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.". Oncotarget 6 27 (2015): 24404-24423. http://europepmc.org/abstract/med/26213336. 10.18632/oncotarget.4380 Trindade, Alexandre; Murta, D.; Batista, M.; Trindade, A.; Silva, E.; Mateus, L.; Duarte, A.; Lopes-Da-Costa, L.. "Dynamics of Notch signaling in the mouse oviduct and uterus along the estrous cycle". Reproduction, Fertility and Development 28 11 (2015): 1663-1678. http://www.publish.csiro.au/paper/RD15029.htm. http://dx.doi.org/10.1071/RD15029 Murta, D.; Batista, M.; Silva, E.; Trindade, A.; Mateus, L.; Duarte, A.; Lopes-Da-Costa, L.. "Differential expression of Notch component and effector genes during ovarian follicle and corpus luteum development during the oestrous cycle". Reproduction, Fertility and Development 27 7 (2015): 1038-1048. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940053375&partnerID=MN8TOARS. 10.1071/RD13399 Djokovic, D.; Trindade, A.; Gigante, J.; Pinho, M.; Harris, A.L.; Duarte, A.. "Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas". BMC Cancer 15 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940029939&partnerID=MN8TOARS. 10.1186/s12885-015-1605-2 Jahnsen, E.D.; Trindade, A.; Zaun, H.C.; Lehoux, S.; Duarte, A.; Jones, E.A.V.. "Notch1 Is pan-endothelial at the onset of flow and regulated by flow". PLoS ONE 10 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84926500454&partnerID=MN8TOARS. 10.1371/journal.pone.0122622 Pedrosa, A.-R.; Trindade, A.; Fernandes, A.-C.; Carvalho, C.; Gigante, J.; Tavares, A.T.; Diéguez-Hurtado, R.; et al. "Endothelial jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1". Arteriosclerosis, Thrombosis, and Vascular Biology 35 5 (2015): 1134-1146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933037146&partnerID=MN8TOARS. 10.1161/ATVBAHA.114.304741 Murta, D.; Batista, M.; Trindade, A.; Silva, E.; Henrique, D.; Duarte, A.; Lopes-da-Costa, L.. "In vivo Notch signaling blockade induces abnormal spermatogenesis in the mouse". PLoS ONE 9 11 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84913534506&partnerID=MN8TOARS. 10.1371/journal.pone.0113365 Murta, D.; Batista, M.; Silva, E.; Trindade, A.; Henrique, D.; Duarte, A.; Lopes-da-Costa, L.. "Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle". PLoS ONE 8 8 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883404801&partnerID=MN8TOARS. 10.1371/journal.pone.0072767 Cristofaro, B.; Shi, Y.; Faria, M.; Suchting, S.; Leroyer, A.S.; Trindade, A.; Duarte, A.; et al. "Dll4-notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models". Development (Cambridge) 140 8 (2013): 1720-1729. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875442488&partnerID=MN8TOARS. 10.1242/dev.092304 Liu, R.; Trindade, A.; Sun, Z.; Kumar, R.; Weaver, F.A.; Krasnoperov, V.; Naga, K.; Duarte, A.; Gill, P.S.. "Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues". Biochemical and Biophysical Research Communications 418 1 (2012): 173-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863403912&partnerID=MN8TOARS. 10.1016/j.bbrc.2012.01.002 Trindade, A.; Djokovic, D.; Gigante, J.; Badenes, M.; Pedrosa, A.-R.; Fernandes, A.-C.; Lopes-da-Costa, L.; et al. "Low-Dosage inhibition of DLL4 signaling promotes wound healing by inducing functional Neo-Angiogenesis". PLoS ONE 7 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855938803&partnerID=MN8TOARS. 10.1371/journal.pone.0029863 Real, C.; Remédio, L.; Caiado, F.; Igreja, C.; Borges, C.; Trindade, A.; Pinto-do-Ó, P.; et al. "Bone marrow-derived endothelial progenitors expressing delta-like 4 (Dll4) regulate tumor angiogenesis". PLoS ONE 6 4 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953685607&partnerID=MN8TOARS. 10.1371/journal.pone.0018323 Djokovic, D.; Trindade, A.; Gigante, J.; Badenes, M.; Silva, L.; Liu, R.; Li, X.; et al. "Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis". BMC Cancer 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78549253191&partnerID=MN8TOARS. 10.1186/1471-2407-10-641 Benedito, R.; Trindade, A.; Hirashima, M.; Henrique, D.; Da Costa, L.L.; Rossant, J.; Gill, P.S.; Duarte, A.. "Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli". BMC Developmental Biology 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-59649084735&partnerID=MN8TOARS. 10.1186/1471-213X-8-117 Trindade, A.; Kumar, S.R.; Scehnet, J.S.; Lopes-Da-costa, L.; Becker, J.; Jiang, W.; Liu, R.; Gill, P.S.; Duarte, A.. "Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos". Blood 112 5 (2008): 1720-1729. http://www.scopus.com/inward/record.url?eid=2-s2.0-52649121738&partnerID=MN8TOARS. 10.1182/blood-2007-09-112748 Scehnet, J.S.; Jiang, W.; Kumar, S.R.; Krasnoperov, V.; Trindade, A.; Benedito, R.; Djokovic, D.; et al. "Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion". Blood 109 11 (2007): 4753-4760. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247479498&partnerID=MN8TOARS. 10.1182/blood-2006-12-063933 Duarte, A.; Hirashima, M.; Benedito, R.; Trindade, A.; Diniz, P.; Bekman, E.; Costa, L.; Henrique, D.; Rossant, J.. "Dosage-sensitive requirement for mouse Dll4 in artery development". Genes and Development 18 20 (2004): 2474-2478. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444261424&partnerID=MN8TOARS. 10.1101/gad.1239004
Thesis / Dissertation	Trindade, Alexandre. "Analysis on the function of Delta4 in the regulation of embryonic angiogenesis and tumoral neo-angiogenesis". PhD, Universidade de Lisboa Faculdade de Medicina Veterinária, 2008. http://hdl.handle.net/10400.5/511. Trindade, Alexandre. "Production of a transgenic mouse line conditionally overexpressing mdelta4". Degree, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2002.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2018/11/17	Developmental versus oncogenic Notch function in the prostate. Exploring the boundaries of animal, veterinary and biomedical sciences.	CIISA Congress 2018 Centro Interdisciplinar de Investigação em Sanidade Animal (Lisboa, Portugal)
2014/10/23	Dll4Fc concurrent systemic therapy improves tumor drug delivery with considerable gain of therapeutic efficacy.	Vascular Biology 2014 North American Vascular Biology Organization (Asilomar, United States)
2010/11/03	Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.	MedImmune European Oncology Research Competition MedImmune (Cambridge, United Kingdom)
2010/03/10	Dll4 inhibition therapy can accelerate wound healing by inducing functional neo-angiogenesis: a matter of dosage.	1st São Paulo School of Translational Science Hospital AC Camargo (São Paulo, Brazil)
2009	Dll4 inhibition therapy can accelerate wound healing by inducing functional neo-angiogenesis: a matter of dosage.	IGC Post-Doc retreat Instituto Gulbenkian de Ciência (Sesimbra, Portugal)
2008	Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.	MRC-IGC Student Meeting Instituto Gulbenkian de Ciência (Ericeira, Portugal)
2007	Sobre-expressão de dll4 provoca hipertrofia arterial e defeitos vasculares através do bloqueio de vias pró-angiogénicas.	Jornadas do ensino pós graduado da FMV Centro de Investigação Interdisciplinar em Sanidade Animal (Lisboa, Portugal)
2006	Overexpression of delta-like 4 attenuates vessel formation and induces arterialization in developing mouse embryos vasculature.	First annual meeting of Gulbenkian Students Gulbenkian Institute of Science (Oeiras, Portugal)
2005	Dll4 overexpression causes arterial hypertrophy and loss of vascular identity in developing mouse embryos.	PDIGC Annual meeting Gulbenkian Institute of Science (Oeiras, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/07/01 - Current	Real-time personalized learning using cardiovascular stress markers in a histology learning software (HistoGYM): the impact of stress on visual memory Supervisor	Centro de Investigação Interdisciplinar Egas Moniz, Portugal
2022/09/01 - Current	A Mosca Soldado Negro como ferramenta de Biorremediação: uma perspetiva One Health Co-supervisor	PhD in Biomedicine (PhD) Centro de Investigação Interdisciplinar Egas Moniz, Portugal
2020/10/01 - 2021/07/31	Avaliação do potencial da Nisina Z no controlo de infeções por Estafilococos resistentes Co-supervisor	Integrated Masters in Veterinary Medicine, FMV/ULisboa. (Master) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2019/10/01 - 2020/11/30	Vascular characterisation of testicular tumors in dogs Co-supervisor of CLAUDIA CRISTINA DOS SANTOS ROQUE ALVARADO	Integrated Masters in Veterinary Medicina (Master) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2011/03/01 - 2019/10/02	The role of endothelial Dll4 in cancer metastasis Co-supervisor	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009/11/01 - 2016/01/12	The role of Jagged1 in adult angiogenesis and in solid tumor development Co-supervisor	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/07/05 - 2023/07/07	6th Egas Moniz International Scientific Congress - "Immediate and Future Challenges to Promote One Health" (2023/07/05 - 2023/07/07) Conference (Member of the Organising Committee)	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2018/03/01 - 2018/11/17	Exploring the boundaries of animal, veterinary and biomedical sciences (2018/11/16 - 2018/11/17) Conference (Member of the Organising Committee)	Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2021/12/20	Role of mitofusin-2 in non-alcoholic fatty liver disease and targeting by microRNAs (Thesis) Main arguer	Pedro Amaral Picado (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/12/11	Histological characterisation of the NLRP3 inflammasome in the ovary of obese mice (Thesis) Main arguer	Joana Proença Gonçalves Pita de Oliveira (Master) Universidade Lusófona de Humanidades e Tecnologias Faculdade de Medicina Veterinária, Portugal

Association member

	Society Organization name	Role
2016 - Current	European Society for Microcirculation
2015 - Current	The European Association for Cancer Research (EACR20999)
2015 - Current	The Portuguese Association for Cancer Research (ASPIC160)
2011 - Current	The North American Vascular Biology Association (00017003)

Committee member

	Activity description Role	Institution / Organization
2024/01/01 - Current	Head of the Research Group "Technologies and Solutions in Healthcare" Coordinator	Centro de Investigação Interdisciplinar Egas Moniz, Portugal
2023/09/03 - Current	Course Coordinator for Degree in Biomedical Sciences at Egas Moniz School of Health & Science Coordinator	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2021/12/05 - Current	Member of the Direction of the Portuguese Society for Veterinary Sciences Other	Sociedade Portuguesa de Ciências Veterinárias, Portugal
2019/03/01 - 2024/06/30	Coordinating committee of CIISA Member	Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Conference scientific committee

	Conference name	Conference host
2018/02/01 - 2018/11/30	Exploring the boundaries of animal, veterinary and biomedical sciences	Faculty of Veterinary Medicina, University of Lisbon

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2022 - Current	Scientific Thinking, Introduction to Diagnosis, Animal Body Function I, II, III, IV, V, VII, VIII and IX.	Medicina Veterinária (Mestrado integrado)	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2021/09/01 - Current	Animal Organism I, II & III	Mestrado Integrado em Medicina Veterinária (Mestrado integrado)	Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2018/09/23 - 2021/08/31	Physiology	Veterinary Medicine (Licenciatura)	Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2020/01/01 - Current	Science Fund of the Republic of Serbia, Program IDEAS Evaluator. Evaluator	Fond za nauku Republike Srbije, Serbia	Fond za nauku Republike Srbije
2015/11/22 - 2015/11/26	Evaluation of project proposals for funding decision Evaluator	North West Cancer Research, United Kingdom	North West Cancer Research

Mentoring / Tutoring

	Topic	Student name
2020/10/01 - 2021/06/30	Histologic mapping of the Notch signalling pathway at mouse embryonic day 16	Tetyana Pryschepova
2021/02/22 - 2021/05/31	Histologic mapping of the Notch signalling pathway at mouse embryonic day 18	Maria Ruivo
2021/02/17 - 2021/05/31	Histologic mapping of the Notch signalling pathway at mouse embryonic day 13	Inês Oliveira

Distinctions

Award

2023	Prémio de Inovação Pedagógica Egas Moniz 2023 Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2022	Prémio de Inovação Pedagógica Egas Moniz 2022 Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2010	2nd MedImmune European Oncology Research Competition - 2nd Prize. AstraZeneca UK Ltd, United Kingdom
2009	Prémio Jovens Investigadores UTL/Caixa Geral de Depósitos - Área de Ciencias Veterinárias Caixa Geral de Depositos, Portugal

Other distinction

2011	Diploma of Scientific Merit Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal