Beatriz Columbano Almeida (2816-8C5B-DA82)

Curriculum Vitae

Beatriz Columbano Almeida

Identification

Personal identification

Full name: Beatriz Columbano Almeida

Citation names

Almeida, Beatriz C.

Author identifiers

Ciência ID: 2816-8C5B-DA82
ORCID iD: 0000-0002-1278-803X
Researcher Id: O-3949-2017

Knowledge fields

Natural sciences - Biological Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2020 - 2024 Ongoing	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal "The role of Zinc in transcription factor allosteric regulation" (THESIS/DISSERTATION)
2015/10 - 2017/12 Concluded	Genética Forense (Mestrado) Major in Sem especialização Universidade do Porto Faculdade de Ciências, Portugal "Portuguese and Taiwanese Machado-Joseph disease haplotype backgrounds" (THESIS/DISSERTATION)	18/20
2016/12 Concluded	Analysis of Data from Molecular Techniques (Outros) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	87%
2012 - 2015 Concluded	Genetic and Biotechnology (Licenciatura) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal "Isolamento e caracterização molecular de Staphylococcus spp. isolados de furões, doninhas e ouriços-cheiro." (THESIS/DISSERTATION)	14/20

Affiliation

Science

	Category Host institution	Employer
2018/09 - 2020/08	Researcher (Research)	CNC.IBILI, Portugal
	Universidade de Coimbra, Portugal

Projects

Grant

	Designation	Funders
2019/12/04 - 2020/08	Rational design of endonucleases IF/01272/2015 Research Fellow Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/09/03 - 2019/11/30	Rational design of a thermostable esterase for the production of high-value bioplastics for biomedical applications MIT-EXPL/ISF/0021/2017 Research Fellow Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference poster

Almeida, Beatriz C.; Kaczmarek, Jennifer A; Prather, Kristala L. J.; Alexandra T.P. Carvalho. "Allosteric transcription factors: essential residues". Paper presented in 8th Annual CCPBioSim Conference - Frontiers in Biomolecular Simulation 2022, 2022.
González, Ricardo D.; Figueiredo, Pedro; Almeida, Beatriz C.; Carvalho, Alexandra T. P.. "Peptide Nucleic Acids modifications with enzymes". Paper presented in Next Generation Biocatalysis, 2021.
Figueiredo, Pedro; González, Ricardo D.; Almeida, Beatriz C.; Carvalho, Alexandra T. P.. "Poly(e-caprolactone) enzymatic synthesis". Paper presented in Next Generation Biocatalysis, 2021.
Almeida, Beatriz C.; Kaczmarek, Jennifer; Pedro R. Figueiredo; González, Ricardo D.; Prather, Kristala L. J.; Carvalho, Alexandra T. P.. "Transcription factor allosteric regulation: substrate coordination to zinc". Paper presented in Next Generation Biocatalysis, 2021.
González, Ricardo D.; Pedro R. Figueiredo; Almeida, Beatriz C.; Carvalho, Alexandra T. P.. "Single stranded Peptide Nucleic Acids as Therapeutic Tool". Paper presented in EuroNanoForum, 2021.
Almeida, Beatriz C.; Kaczmarek, Jennifer; Pedro R. Figueiredo; González, Ricardo D.; Prather, Kristala L. J.; Carvalho, Alexandra T. P.. "Allosteric transcription factor: regulation through zinc coordination". Paper presented in EuroNanoForum, 2021.
González, Ricardo D.; Pedro R. Figueiredo; Almeida, Beatriz C.; Carvalho, Alexandra T. P.. "Enzymatic modification of peptide nucleic acids conjugates for cell delivery". Paper presented in Oligonucleotide Technologies and Therapeutics@Portugal, 2021.
Almeida, Beatriz C.; Kaczmarek, Jennifer; Pedro R. Figueiredo; González, Ricardo D.; Prather, Kristala L. J.; Alexandra T. P. Carvalho. "Allosteric characterization of a GntR transcription factor". Paper presented in Quantifying Protein Dynamics and Allosteric regulation in the cell with emerging technologies: From Cryo-EM and NMR to Multiscale Simulations, Networks and Machine Learning, 2021.
Almeida, Beatriz C.; Figueiredo R. Pedro; Alexandra TP Carvalho. "From common plastics to sustainable alternatives: A mechanistic study of a green catalyst". Paper presented in Microbiotec’19, 2019.
Figueiredo R. Pedro; Almeida, Beatriz C.; Alexandra TP Carvalho. "Enzymatic transesterification of PCL-PEG co-polymers". Paper presented in Microbiotec'19, 2019.
Almeida, Beatriz C.; Figueiredo, Pedro; ATP, Carvalho. "Rational design of enzymatic production of high-value biodegradable polymers". Paper presented in 7th Annual CCPBioSim Conference - Frontiers in Biomolecular Simulation, 2019.
Figueiredo, Pedro; Almeida, Beatriz C.; Carvalho, Alexandra T. P.. "Enzymatic synthesis of poly(e-caprolactone): a QM/MM MD study". Paper presented in 7th Annual CCPBioSim Conference - Frontiers in Biomolecular Simulation, 2019.
Carvalho, Alexandra T. P.; Almeida, Beatriz C.; Figueiredo, Pedro. "Rational design of enzymatic production of high-value biodegradable polymers for biomedical applications". Paper presented in BioTrans Symposium 2019, 2019.
Almeida, Beatriz C.; Figueiredo, Pedro; ATP, Carvalho. "Rational design of enzymatic production of high value biodegradable polymers for biomedical applications". Paper presented in Ageing: Models, mechanisms and their applies, 2019.
Almeida, Beatriz C; Carvalho, ATP. "QM/MM studies on a thermophilic esterase". Paper presented in CECAM workshop Multiscale Modeling from Macromolecules to Cell: Opportunities and Challenges of Biomolecular Simulations, 2019.
Almeida, BC; Carvalho, ATP. "Rational design of a thermostable esterase for the production of highvalue bioplastics for biomedical applications.". Paper presented in MIT Portugal Conference, 2018.
Beatriz Columbano, Margarida Sousa, Joana Rodrigues, Vanessa Correia, Nuno Silva, Tiago Rodrigues, Gilberto Igrejas, Pat. "Caracterização fenotípica e genotípica de Staphylococcus spp. isolados de pequenos mamíferos selvagens dos Açores.". Paper presented in VII Jornadas de Genética e Biotecnologia., 2015.
Joana Rodrigues, Margarida Sousa, Beatriz Columbano, Vanessa Correia, Nuno Silva, Tiago Rodrigues, Patrícia Poeta, Gilbe. "Caracterização fenotípica e genotípica de Staphylococcus spp. Isolados de coelhos selvagens dos Açores.". Paper presented in II Jornadas de Genética e Biotecnologia, 2015.
Vanessa Correia, Margarida Sousa, Joana Rodrigues, Beatriz Columbano, Nuno Silva, Tiago Rodrigues, Patrícia Poeta, Gilbe. "Podemos encontrar genes de resistência a antibióticos em estirpes de Escheriachia coli portadoras de beta-lactamases de largo espectro isoladas de aves migratórias?". Paper presented in VII Jornadas de Genética e Biotecnologia., 2015.

Journal article

Beatriz C. Almeida; Pedro R. Figueiredo; Daniel F.A.R. Dourado; Stephanie Paul; Andreia F. Sousa; Armando J.D. Silvestre; Derek J. Quinn; Thomas S. Moody; Alexandra T.P. Carvalho. "Development of Enzymatic Variants for the Synthesis of Bioresorbable Polyesters". Organic Process Research & Development (2022): https://doi.org/10.1021/acs.oprd.1c00480.
10.1021/acs.oprd.1c00480
Pedro R. Figueiredo; Sónia F. G. Santos; Beatriz C. Almeida; Isaura Simões; Alexandra T. P. Carvalho. "Introduction of a Glycine Linker Connecting the Heavy and Light Chains in Synthetic Cardosin B-Derived Rennet Changes the Specificity of Subpocket S3'". The Journal of Physical Chemistry B (2021): https://doi.org/10.1021/acs.jpcb.1c01826.
Published • 10.1021/acs.jpcb.1c01826
Almeida, Beatriz C; Kaczmarek, Jennifer A; Figueiredo, Pedro R; Prather, Kristala L J; Carvalho, Alexandra T P. "Transcription factor allosteric regulation through substrate coordination to zinc". NAR Genomics and Bioinformatics 3 2 (2021): http://dx.doi.org/10.1093/nargab/lqab033.
Published • 10.1093/nargab/lqab033
Figueiredo, Pedro; Almeida, Beatriz; Dourado, Daniel F.A.R; Sousa, Andreia; Silvestre, Armando; Pires Carvalho, Alexandra Teresa. "Enzymatic Synthesis of Polyesters: a QM/MM study". ChemCatChem (2020): http://dx.doi.org/10.1002/cctc.202000780.
Published • 10.1002/cctc.202000780
Figueiredo, Pedro; Almeida, Beatriz C.; Carvalho, Alexandra T. P.. "Enzymatic Polymerization of PCL-PEG Co-polymers for Biomedical Applications". Frontiers in Molecular Biosciences 6 (2019): http://dx.doi.org/10.3389/fmolb.2019.00109.
Published • 10.3389/fmolb.2019.00109
Almeida, Beatriz C.; Figueiredo, Pedro; Carvalho, Alexandra T. P.. "Polycaprolactone Enzymatic Hydrolysis: A Mechanistic Study". ACS Omega 4 4 (2019): 6769-6774. http://dx.doi.org/10.1021/acsomega.9b00345.
Published • 10.1021/acsomega.9b00345
Costa, Inês P. D.; Almeida, Beatriz C.; Sequeiros, Jorge; Amorim, António; Martins, Sandra. "A Pipeline to Assess Disease-Associated Haplotypes in Repeat Expansion Disorders: The Example of MJD/SCA3 Locus". Frontiers in Genetics 10 (2019): http://dx.doi.org/10.3389/fgene.2019.00038.
Published • 10.3389/fgene.2019.00038

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021	Computational studies on enzymatic polymerizations	PDBEB Courses 2020/2021-Computational Biology
2021	Hands-on session: Molecular Dynamics	PDBEB Courses 2020/2021-Computational Biology
2018/03	Mutational origins of Machado-Joseph disease in patients from Portugal and Taiwan	X Jornadas de Genética e Biotecnologia Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2017/11	Machado-Joseph disease mutational events in Portuguese and Taiwanese populations	6th ANNUAL MEETING Instituto de Investigação e Inovação em Saúde- i3S (Póvoa de Varzim, Portugal)

Event participation

	Activity description Type of event	Event name Institution / Organization
2021/09/15 - 2021/09/17	Quantifying Protein Dynamics and Allosteric regulation in the cell with emerging technologies: From Cryo-EM and NMR to Multiscale Simulations, Networks and Machine Learning Workshop	Quantifying Protein Dynamics and Allosteric regulation in the cell with emerging technologies: From Cryo-EM and NMR to Multiscale Simulations, Networks and Machine Learning CECAM, Switzerland
2021/02/11 - 2021/02/12	An International Young Investigator Virtual Symposium Symposium	Next Generation Biocatalysis
2019/12/19 - 2019/12/20	A meeting with the aim to promote and strength the scientific excellence of the Centre for Innovative Biomedicine and Biotechnology. Meeting	CIBB Meeting Universidade de Coimbra, Portugal
2019/12/05 - 2019/12/07	This biennale conference although directed at the Portuguese scientists, aims to provide an international scientific forum by which researchers from all over the world share their knowledge, exchange ideas, and discuss scientific policy and regulatory issues associated with the microbiology and the biotechnology in the future. The debate will also be focused on the relationship with industry, the creation of a network of culture collections in Portugal, or the risks to food safety. Congress	Microbiotec'19 Universidade de Coimbra, Portugal
2019/09/04 - 2019/09/06	The 7th annual meeting of CCP-BioSim is organized jointly with the Molecular Graphics and Modelling Society and will have the theme of Modelling and Simulation for Synthetic Biology. The conference will showcase important advances in biomolecular modelling and simulation tools, technologies, interplay with experiment, and applications to biomolecular design and synthetic biology. Conference	7th Annual CCPBioSim Conference - Frontiers in Biomolecular Simulation University of Bristol School of Chemistry, United Kingdom
2019/06/28 - 2019/06/29	This conference will have the contribution of renowned scientists from 3 continents that will discuss for 2 days new approaches to model, prevent and treat ageing-related diseases. Conference	Ageing: models, mechanisms and therapies Universidade de Coimbra, Portugal
2019/02/04 - 2019/02/06	Multiscale Modeling from Macromolecules to Cell: Opportunities and Challenges of Biomolecular Simulations Workshop	École Polytechnique Fédérale de Lausanne, Switzerland
2018/03/22 - 2018/03/23	18th Meeting Portugaliæ Genetica Meeting	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2016/03/17 - 2016/03/18	17th Meeting Portugaliae Genetica Meeting	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2015/04/09 - 2015/04/10	4th Edition of the Bioinformatics Open Days Congress	Universidade do Minho, Portugal
2015/03/26 - 2015/03/28	VII Jornadas de Genética e Biotecnologia Congress	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2015/03 - 2015/03	V Palestras Solidárias de Genética e Biotecnologia Seminar	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2014/03/09 - 2014/03/09	II Encontro Nacional de Estudantes de Biotecnologia Meeting	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2014/03/06 - 2014/03/08	VI Jornadas Nacionais de Genética e Biotecnologia Congress	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2014/03 - 2014/03	Ano Internacional de Cristalografia Conference	Universidade de Trás-os-Montes e Alto Douro, Portugal
2014/03 - 2014/03	4º Ciclo de Palestras de Genética e Biotecnologia Seminar	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2014/02 - 2014/02	2º Ciclo de Palestras de Genética e Biotecnologia Seminar	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2013/02/20 - 2013/02/22	V Jornadas Nacionais de Genética e Biotecnologia Congress	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2012/11 - 2012/11	I Palestras de Neurociências Seminar	Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal

Distinctions

Other distinction

2022	Fulbright Grant for Research with the support of FCT Fulbright Portugal, Portugal