
Curriculum Vitae
Andreia Alexandra Neves de Carvalho
Andreia Neves-Carvalho graduated in Applied Biology by the University of Minho in 2006. She has been focused on merging fundamental
and translational questions. She studies the physiological role of Ataxin-3 (ATXN3) as a path towards a better understanding
of the pathogenic mechanism of Spinocerebellar Ataxia Type 3 (SCA3) and other proteinopathies, and definition of targets for
development of effective treatments. During a consolidation period, she worked in the Molecular Biology and Functional Genomics
field, using the nematode C. elegans as a model, which became her MSc thesis project on Molecular Genetics. From 2009-2014
she integrated a Health Sciences Doctoral programme and developed her PhD thesis in collaboration with two groups at Vrije
University at Amsterdam, led by Prof Ka Wan Li and Prof Peter Heutink. She developed neuronal lines to screen for molecular
partners and targets for ATXN3’s deubiquitylating activity, generating a large amount of data by high throughput assays that
can be further explored by us and researchers worldwide, as well as important tools for the field such as cellular models
(cell lines and primary cultures), molecular characterization of protein function and interactions, and analysis of the ubiquitome,
her main contribution to the field, allowed collaborations in projects in diverse fields such as use of MSCs to study neural/glial
proliferation and differentiation, and Tau pathology. She has also described a new substrate for ATXN3’s deubiquitylating
function in neurons and new role of ATXN3 in splicing regulation, in particular splicing of Tau, which establishes a link
between two proteins involved in different neurodegenerative disorders. In parallel, She contributed to the characterization
of a SCA3 mouse model as well as to various pre-clinical trials to test the effect of different drugs for SCA3 such as 17-DMAG,
Lithium Chloride, Valproic acid, Creatine and Citalopram, contributing for the discovery of new compounds for possible use
in SCA3 therapy. She started her post doctoral training in 2015, focused on dissecting the structure-function correlations
in the cerebellum in the context of SCA3, to define targets for future therapeutic approaches and identify relevant biomarkers
for preclinical trials. More recently, she started performing in vivo freely moving electrophysiological studies in our SCA3
mouse in collaboration with Dr Khodakhah (Albert Einstein College of Medicine), a relatively new technique in Portugal. To
date, she has supervised 2 MSc and 2 PhD students in their lab rotations. She received 12 awards and published 14 original
articles with accumulated IF = 71.33 (average IF = 5.095).
Identification
Personal identification
- Full name
- Andreia Alexandra Neves de Carvalho
- Date of birth
- 1984/03/27
- Gender
- Female
Citation names
- Neves-Carvalho, Andreia
Author identifiers
- Ciência ID
- 281E-C57D-5DA3
- ORCID iD
- 0000-0002-5710-0040
Email addresses
- andreiacarvalho@med.uminho.pt (Professional)
- andreia.an.carvalho@gmail.com (Personal)
Telephones
- Telephone
-
- 253605835 Ext.: 604835 (Professional)
Addresses
- Instituto de Ciências da Vida e da Saúde (ICVS). Escola de Ciências da Saúde, Campus de Gualtar, Universidade do Minho, 4710, Braga, Braga, Portugal (Professional)
Websites
- http://www.icvs.uminho.pt (Professional)
- http://www.icvs.uminho.pt/about-icvs/people/andreiacarvalho (Professional)
Knowledge fields
- Social Sciences - Media and Communications
- Exact Sciences - Mathematics - Statistics and Probability
- Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
- Exact Sciences - Mathematics - Statistics and Probability
- Exact Sciences - Computer and Information Sciences - Bioinformatics
- Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging
- Natural sciences - Biological Sciences - Biochemical Research Methods
- Natural sciences - Biological Sciences - Cell Biology
- Natural sciences - Biological Sciences - Cell Biology
- Social Sciences - Media and Communications
- Medical and Health Sciences - Basic Medicine
- Medical and Health Sciences - Basic Medicine
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
Spanish; Castilian | Beginner (A1) | Beginner (A1) | Beginner (A1) | Beginner (A1) | Beginner (A1) |
Portuguese (Mother tongue) |
Education
Degree | Classification | |
---|---|---|
2020
Ongoing
|
Postdoctoral Fellow (Pós-doutoramento)
Major in Neurosciences
Universidade do Minho, Portugal
|
n/a |
2009 - 2014
Concluded
|
Health Sciences (Doutoramento)
Major in Health Sciences
Universidade do Minho Escola de Medicina, Portugal
Vrije University Amsterdam Onderzoeksgroep Organische Chemie, Netherlands "When gaining is losing: insights into the function of ataxin-3 and its perturbation in the context of Machado-Joseph disease" (THESIS/DISSERTATION)
|
Aprovado por unanimidade |
2009
Concluded
|
Molecular Genetics MSc (Mestrado)
Major in Molecular Genetics MSc
Universidade do Minho Escola de Ciências, Portugal
"Increased thermotolerance in the absence of ataxin-3 in C. elegans" (THESIS/DISSERTATION)
|
19 |
2007
Concluded
|
Aplied Biology (Licenciatura)
Major in Aplied Biology
Universidade do Minho Escola de Ciências, Portugal
"Estudo de parceiros moleculares da proteina de C.elegans envolvida na doença de Machado-Joseph, ATX-3" (THESIS/DISSERTATION)
|
15 |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2014/12/01 - Current | Postdoc (Research) | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
Others
Category Host institution |
Employer | |
---|---|---|
2017/09/01 - Current | Posdoctoral fellowship: "Study of Cerebellar (Dys)function in Spinocerebellar Ataxia Type 3" | Fundação para a Ciência e a Tecnologia, Portugal |
2016/06/01 - 2017/12/31 | Posdoctoral grant: “Study of Tau splicing in the context of Machado-Joseph disease” | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2017/02/15 - 2017/08/31 | Posdoctoral grant:" Testing the therapeutic potential of Mesenchymal Cells and their secretive in an animal model of spinocerebellar ataxia type 3" | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2014/03/01 - 2015/05/28 | Research grant: “Estudo da função da ubiquitina hydrolase ataxina-3 em neurónios” | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2009/09/01 - 2014/12/01 | PhD student | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2008/01/01 - 2013/12/31 | Team member of a scientific project: PTDC/SAU-GMG/101572/2008 – “Ataxin-3: gain and loss of Machado-Joseph Disease” | Fundação para a Ciência e a Tecnologia, Portugal |
2007/09/01 - 2008/07/15 | Especialidade em Genética Molecular | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2006/12/01 - 2007/12/31 | Estágio | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2016/01/02 - 2016/12/31 | Testing the Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in an Animal Model of Spinocerebellar Ataxia
Type 3
NAF_PI_2016(ID1087)
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
National Ataxia Foundation
Concluded
|
2013/05 - 2015/09 | Proteostasis as a link between longevity pathways and neurodegenerative diseases
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2010/04 - 2013/09 | Ataxin-3: gain and loss of function in Machado-Joseph disease
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2007 - 2012 | Atraso Mental Idiopático: avaliação de uma esratégia de microarray CGH para diagnostico genético
Atraso Mental Idiopático: avaliação de uma esratégia de microarray CGH para diagnostic genético
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Concluded
|
Contract
Designation | Funders | |
---|---|---|
2018 - 2021 | Combining Mesenchymal Stem Cells (MSCs) Secretome and Pharmacotherapies for the treatment of Parkinson's Disease
POCI-01-0145-FEDER-029751
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018 - 2020 | Nuclear Ataxin-3 Protein-protein Interactions as Therapeutic Targets in Machado-Joseph Disease
GFP-NAPPIT-MJD-04/2019
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2007 - 2012 | Atraso Mental Idiopático: avaliação de uma esratégia de microarray CGH para diagnostic genético
PIC//IC/83026/2007
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
Conference poster |
|
Journal article |
|
Thesis / Dissertation |
|
Other
Other output |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2019 | Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors: implication for disease | RNA Meeting: ptRNA2019
(Porto, Portugal)
|
2019 | Study of Cerebellar circuits (Dys)function in Spinocerebellar Ataxia Type 3 | Molecular Neuroscience: From genes to circuits in health and disease
EMBO (Bangalore, India)
|
2019 | Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors | International Ataxia Research Conference
(United States)
|
2019 | Microglial and astrocytic pathology in a mouse model of Machado-Joseph disease | IV Symposium of the Portuguese Glial Network; |
2019 | Microglial and astrocytic pathology in a mouse model of Machado-Joseph disease | International Ataxia Research Conference |
2018 | Testing the Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in an Animal Model of Machado-Joseph disease | Portuguese Society of Movement disorders
(Curia, Portugal)
|
2018 | Testing peripheral BDNF gene delivery using neuron-targeted nanoparticles as a strategy to reduce skeletal muscle atrophy and motor neuronopathy in a mouse model of SCA3 | Portuguese Society of Movement Disorders |
2017 | Study of the function of ATXN3, a DUB enzyme involved in Machado-Joseph disease | Bioinformatics postgraduation course
Universidade do Minho (Braga, Portugal)
|
2017 | Transfection methods: overview | Molecular and cellular analysis posgraduation course
Universidade do Minho (Braga, Portugal)
|
2017 | Neuroprotective effects of creatine-supplemented diet in the CMVMJD135 mouse model of Machado-Joseph disease | V Jornadas de Química e Bioquímica
Universidade da Beira Interior (Portugal)
|
2017 | Loss of function of ATXN3 alters the ubiquitome of neuronal cells, negatively impacting on the splicing process | São Paulo School of Advanced Science on Mass Spectrometry -based Proteomics (SPSAS-MS)
Universidade de Campinas - UNICAMP (Campinas, Brazil)
|
2017 | ATXN3 modulates mRNA splicing of Tau through ubiquitylation of splicing factors | Portuguese Society for Neuroscience (SPN) 2017
Portuguese Society for Neuroscience (SPN) (Braga, Portugal)
|
2017 | Regulation of neuronal mRNA splicing by ATXN3 is disturbed in SCA3/MJD | International Ataxic Research Conference (IARC) - 2017
International Ataxic Research Conference (IARC) (Pisa, Italy)
|
2017 | Neuroprotective effects of creatine-supplemented diet in the CMVMJD135 mouse model of Machado-Joseph disease | Portuguese Society of Movement disorders - 2017
Portuguese Society of Movement disorders (Portugal)
|
2016 | TUDCA reduces neuroinflammation and improves motor symptoms in a transgenic mouse model of Machado-Joseph disease | Ataxia Investigators Meeting (AIM) - 2016
Ataxia Investigators Meeting (AIM) (Florida, United States)
|
2015 | Citalopram treatment ameliorates motor impairment and suppresses ataxin-3 aggregation in a Machado-Joseph disease mouse model | Ataxia Research Conference - 2015
Ataxia Research Conference (Windsor, United Kingdom)
|
2014 | Study of the function of ATXN3, a DUB enzyme involved in Machado-Joseph disease | Bioinformatics postgraduation course
Universidade do Minho (Braga, Portugal)
|
2014 | When gaining is loosing: insights into the function of ataxia-3 and its perturbation in the context of Machado-Joseph Disease | XVIII Congress of the Portuguese Biochemical Society - 2014
XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal)
|
2014 | Mesenchymal stem cells secretome: a new therapeutic tool for Central Nervous System repair? | 6th Meeting FIRST
(Milão, Italy)
|
2013 | Tauroursodeoxycholic acid reduces neuroinflammation and improves motor symptoms in a transgenic mouse model of Machado-Joseph Disease | Portuguese Society of Movement Disorders
(Portugal)
|
2013 | Loss of function of the DUB Ataxin-3 affects differentiation, proliferation and cytoskeletal organization of neuronal cells through the modulation of ITGA5 levels | 5th Annual Ubiquitin Drug Discovery & Diagnostics Conference
(Filadélfia, United States)
|
2012 | 17-DMAG and Valproic Acid improve the phenotype of a new transgenic mouse model of Machado-Joseph Disease | Ataxia Research Conference (ARC)
(Londres, United Kingdom)
|
2009 | Ataxin-3, UBXN-5 and CDC-48: a new trimolecular complex in C. elegans | V International Workshop on Machado-Joseph Disease
(S. Miguel, Portugal)
|
2009 | Increased thermotolerace and hormesis in the absence of ataxin-3 in C. elegans | V International Workshop on Machado-Joseph Disease
(S. Miguel, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2020 - Current | "Ataxin-3 as a biomarker in gliomas"
Supervisor
|
Universidade do Minho, Portugal
|
2020 - 2021 | "Sex differences in Citalopram effect in a Transgenic mouse model of spinocerebellar ataxia type 3"
Supervisor
|
|
2020 - 2021 | "A comprehensive characterisation of the cerebellar (dye)function in spinocerebellar ataxia type 3"
Supervisor
|
Universidade do Minho, Portugal
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2019 - 2019 | XII Annual Scientific Neurosciences Retreat (2019 - 2019) | Universidade do Minho, Portugal |
2018 - 2018 | XII Annual Scientific Neurosciences Retreat (2018 - 2018)
Meeting (Member of the Organising Committee)
|
Universidade do Minho, Portugal |
2018 - 2018 | I Workshop on the Cerebellum (2018 - 2018)
Workshop (President of the Organising Committee)
|
Universidade do Minho, Portugal |
2017 - 2017 | XI Annual Scientific Neurosciences Retreat (2017 - 2017)
Meeting (Member of the Organising Committee)
|
Universidade do Minho, Portugal |
2005 - 2005 | VI Applied Biology students Meeting (2005 - 2005)
Meeting (Member of the Organising Committee)
|
Universidade do Minho, Portugal |
Event participation
Activity description Type of event |
Event name Institution / Organization |
|
---|---|---|
2019 - Current | Poster presentation
Congress
|
RNA Meeting: ptRNA2019
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2017 - Current | Oral communication
Workshop
|
São Paulo School of Advanced Science on Mass Spectrometry -based Proteomics (SPSAS-MS)
Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
|
2018 - 2018 | Poster presentation
Congress
|
7th Ataxia Investigators Meeting
National Ataxia Foundation, United States
|
2018 - 2018 | Oral communication
Congress
|
Portuguese Society of Movement disorders |
2017 - 2017 | Oral communication
Congress
|
International Ataxia Research Conference (IARC) |
2017 - 2017 | Oral communication
Congress
|
XV Portuguese Society for Neuroscience (SPN) |
2015 - 2015 | Poster presentation
Congress
|
XXII Annual Meeting of Portuguese Society for Neurosciences
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2014 - 2014 | Oral communication
Congress
|
5th Ataxia Investigators Meeting
National Ataxia Foundation, United States
|
2014 - 2014 | Oral communication
Congress
|
XVIII Congress of the Portuguese Biochemical Society |
2013 - 2013 | Oral communication
Congress
|
5th Annual Ubiquitin Drug Discovery & Diagnostics Conference
Ubiquitin Conferences, United States
|
2013 - 2013 | Poster presentation
Congress
|
XIII Portuguese Society for Neurosciences (SPN)
Universidade de Coimbra, Portugal
|
2013 - 2013 | Poster presentation
Congress
|
XXXVIII Portuguese Meeting of Genetics
Universidade do Porto, Portugal
|
2012 - 2012 | Poster communication
Congress
|
6th National Meeting on Cell Signaling (SINAL)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
2010 - 2010 | Participation as a student in the EMBO practical course: Ubiquitin and SUMO
Workshop
|
EMBO practical course: Ubiquitin and SUMO
Cancer Research UK, United Kingdom
|
2010 - 2010 | Poster presentation
Congress
|
Proteomics of Protein Degradation & Ubiquitin Pathways (PPDUP)
International Forum of Proteomics, Canada
|
2009 - 2009 | Oral communication
Workshop
|
V Workshop on Machado-Joseph Disease
Universidade dos Açores Departamento de Biologia, Portugal
|
2004 - 2004 | Participation in Applied Biology students Meeting
Meeting
|
VI Meeting of Applied Biology
Universidade do Minho, Portugal
|
2003 - 2003 | Participation in the Applied Biology students Meeting
Meeting
|
V Meeting of Applied Biology
Universidade do Minho, Portugal
|
2002 - 2002 | Participation in the Applied Biology students Meeting
Meeting
|
IV Meeting of Applied Biology
Universidade do Minho, Portugal
|
2000 - 2000 | Workshop within the program "Ciência viva"
Workshop
|
Química Aplicada - Iniciação à Investigação
Ministério da Ciência e da Tecnologia, Portugal
|
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2017 - Current | Laboratory Animal Sciences Advanced course at ICVS - Practical classes | (Curso de doutoramento (conclusão de unidades curriculares)) | Universidade do Minho, Portugal |
2017 - Current | Molecular and Cellular Analysis Course | (Curso de doutoramento (conclusão de unidades curriculares)) | Universidade do Minho, Portugal |
2017 - Current | Bioinformatics course | (Curso de doutoramento (conclusão de unidades curriculares)) | Universidade do Minho, Portugal |
Evaluation committee
Activity description Role |
Institution / Organization | Funding entity | |
---|---|---|---|
2019 - Current | Evaluation of students performance on the Laboratory Animal Sciences course
Evaluator
|
Universidade do Minho, Portugal |
Interview (tv / radio show)
Program | Topic | |
---|---|---|
2017 - 2017 | Filmed at the International Ataxia Research Conference 2017 | Regulation of neuronal mRNA splicing by ATXN3 is disturbed in SCA3/MJD |
Mentoring / Tutoring
Topic | Student name | |
---|---|---|
2019 - Current | Project development | Liliana Costa |
2019 - Current | Project development | Ana Cristina Fernandes |
2019 - Current | Ana Catarina Ferreira | |
2019 - Current | Ana Cristina Fernandes | |
2019 - Current | Liliana Costa | |
2012 - Current | Fátima Lopes | |
2012 - Current | Joana Silva | |
2019 - 2020 | Master in Health Science: Laboratory rotation | Ana Margarida Sousa |
2019 - 2020 | Master in Health Science: Laboratory rotation | Beatriz Ferreira |
2018 - 2019 | Trainnee student: Bachelor in Biochemistry | Catarina Ferreira |
2013 - 2014 | Mestrado | Revina Marslin |
2013 - 2014 | "Stable silencing of Ataxin-3 leads to abnormal differentiation in neuronal cells” | Ana Freitas |
2013 - 2013 | Master in Health Science: Laboratory rotation | Revina Mary Ann Marslin |
2013 - 2013 | Master in Health Science | Ana Freitas |
2013 - 2013 | PhD in Health Sciences: Laboratory rotation | Joana Margarida Mota Silva |
2013 - 2013 | PhD in Health Sciences: Laboratory Rotation | Fátima Daniela Lopes |
Distinctions
Award
2021 | Best work at XIII ENEBIOQ Workshop
Universidade of Trás-os-Montes e Alto Douro, Portugal
|
2019 | Best poster award at the VIII National RNA Meeting: ptRNA 2019: “Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors”, Porto (Portugal) |
2019 | Traveling award for EMBO workshop: from genes to disease (India) |
2019 | Travel grant – participation in the EMBO workshop: from genes to disease |
2019 | 3. Best poster presentation at the VII National RNA Meeting: ptRNA2019 |
2018 | National Ataxia Foundation (NAF) award for the AIM Meeting at Philadelphia (USA)
National Ataxia Foundation, United States
|
2018 | Traveling award for EMBO workshop: from genes to disease (India) |
2018 | 1. Travel grant – participation in the 7th Ataxia Investigators Meeting |
2017 | Sociedade Portuguesa de Doenças do movimento (Portugal) |
2016 | Traveling award for Ataxia UK (Italy)
Ataxia UK, United Kingdom
|
2014 | National Ataxia Foundation (NAF) award for the AIM Meeting at Las Vegas (USA)
National Ataxia Foundation, United States
|
2013 | Best poster presentation – Prize Prof Luís Archer: “17-DMAG induces autophagy and delays disease progression in a mouse model
of Machado-Joseph Disease”
Prize Prof Luís Archer, Portugal
|
2013 | Traveling award for the Ubiquitin Discovery & Diagnostics Conference, Philadelphia (USA) |
2013 | Best Abstract award at the Ubiquitin Discovery & Diagnostics Conference: “Loss of function of the DUB Ataxin-3 affects differentiation, proliferation and cytoskeletal organization of neuronal cell through the modulation of ITGA5 levels”, Philadelphia (USA |
2010 | VXII Rafael Hervada award for Biomedical Research: “Genetic and pharmacological modulation of the IIs and HSF-1 pathways rescues
neuronal proteotoxicity in a C. elegans model of Machado-Joseph disease”,
VXII Rafael Hervada award for Biomedical Research, Spain
|
2009 | Best oral communication at the V International workshop on Machado-Joseph Disease: “Ataxin-3, UBXN-5 and CDC-48: a new trimolecular
complex in C. elegans”,
V International workshop on Machado-Joseph Disease, Portugal
|
2008 | Traveling Award for EMBO Practical course |