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Patricia C. Freire graduated in Biochemistry by the University of Aveiro, Portugal, and obtained her PhD from the Medical University of Vienna, Austria, under the supervision of Georg Stingl. Her doctoral work in the field of immuno-dermatology earned her the Heinrich Auspitz Innovation Award and the Anton Luger Prize, granted by the Austrian Society of Dermatology and Venereology for excellent scientific contributions to the field of immuno-dermatology and for dissertations of outstanding scientific content in the field of clinical and experimental dermatology, respectively. She then received post-doctoral training at the Institute for Systemic Inflammation Research of the University Medical Center Schleswig-Holstein, in Germany, where she focused on the relevance of the classical complement cascade during the development of skin autoimmune diseases. Since joining Exogenus Therapeutics in early 2020, Patricia helped attract over ¿€1Mi in grant and contract funding and has been involved in most aspects of the company, with particular interest in R&D projects.
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Identification

Personal identification

Full name
Patricia Freire

Citation names

  • Freire, Patricia

Author identifiers

Ciência ID
291D-C149-603E
ORCID iD
0000-0001-8916-9782

Websites

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Clinical Medicine - Dermatology and Venereal Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2018/01/24
Concluded
 PhD (Doktor (PhD))
Medizinische Universität Wien, Austria
2013/07/15
Concluded
 Bioquímica (Mestrado)
Universidade de Aveiro, Portugal
 17
Affiliation

Science

Category
Host institution 		Employer
2020/01 - Current Contracted Researcher (Research) Exogenus Therapeutics, SA, Portugal
2018/11 - 2020/01 Postdoc (Research) Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Germany
Projects

Grant

Designation Funders
2020/10/02 - 2021/10/01 EXOLUNG: Umbilical Cord Blood derived exosomes for treatment of COVID-19 related Acute Respiratory Distress Syndrome (ARDS)
CENTRO-01-02B7-FEDER-070018
Post-doc
Exogenus Therapeutics, SA, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2019/12 - 2020/12 TEXAD – Tailoring EXosomes for Autoimmune Diseases
861869
Post-doc
Exogenus Therapeutics, SA, Portugal
 European Innovation Council
Concluded

Contract

Designation Funders
2022/01 - Current Extracellular vesicles as therapeutic tools for regenerative medicine
n/a
Post-doc
Exogenus Therapeutics, SA, Portugal
 Boehringer Ingelheim - Reseach Beyond Borders
Ongoing
Outputs

Publications

Journal article
  1. Rodrigues, Sílvia C.; Cardoso, Renato M. S.; Freire, Patricia C.; Gomes, Cláudia F.; Duarte, Filipe V.; Neves, Ricardo Pires das; Simões-Correia, Joana. "Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders". International Journal of Molecular Sciences 22 18 (2021): 9797. http://dx.doi.org/10.3390/ijms22189797.
    10.3390/ijms22189797
  2. Rodrigues, Silvia C.; Cardoso, Renato M. S.; Gomes, Claudia F.; Duarte, Filipe V.; Freire, Patricia C.; Neves, Ricardo; Simoes-Correia, Joana. "Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles". Membranes 11 9 (2021): 647. http://dx.doi.org/10.3390/membranes11090647.
    10.3390/membranes11090647
  3. Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia. "Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use". STEM CELLS Translational Medicine (2021): https://doi.org/10.1002/sctm.20-0376.
    10.1002/sctm.20-0376
  4. Patricia Colchete Freire; Cristina Herraez Muñoz; Ulla Derhaschnig; Christian Schoergenhofer; Christa Firbas; Graham C. Parry; Sandip Panicker; et al. "Specific Inhibition of the Classical Complement Pathway Prevents C3 Deposition along the Dermal-Epidermal Junction in Bullous Pemphigoid". Journal of Investigative Dermatology 139 12 (2019): 2417-2424.e2. https://doi.org/10.1016/j.jid.2019.04.025.
    10.1016/j.jid.2019.04.025
  5. P.C. Freire; C.H. Muñoz; G. Stingl. "IgE autoreactivity in bullous pemphigoid: eosinophils and mast cells as major targets of pathogenic immune reactants". British Journal of Dermatology 177 6 (2017): 1644-1653. https://doi.org/10.1111/bjd.15924.
    10.1111/bjd.15924
  6. Gomes, Ana T. P. C.; Freire, Patricia C.; Domingos, Catarina R. M.; Neves, Maria G. P. M. S.; Cavaleiro, Jose A. S.; Almeida Paz, Filipe A.; Saraiva, Jorge A.; Tome, Augusto C.. "Synthesis under high hydrostatic pressure - a new method to prepare 5,10,15,20-tetrakis[4-(substituted amino)-2,3,5,6-tetrafluorophenyl]porphyrins". (2016): http://hdl.handle.net/10773/20790.
    10.1142/S108842461650111X
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/05/18 Umbilical cord blood-derived small extracellular vesicles: Immune-modulating properties and regenerative potential for psoriatic lesions International Society for Extracellular Vesicles (ISEV) Annual Meeting
Virtual
2016/09 Contribution of IgE autoantibodies to the pathogenesis of bullous pemphigoid. Pathogenesis of Pemphigus and Pemphigoid (PPP)
(Munich, Germany)
2016/03 IgE Autoreactivity in Bullous Pemphigoid. Autoimmune Bullous Disease Working Group, ADF
(Vienna, Austria)
2016/01 IgE Autoreactivity in Bullous Pemphigoid. OeGDV: "Science Days"
Austrian Society of Dermatology and Veneorology (Bad Aussee, Austria)
2015/09 IgE Autoreactivity in Bullous Pemphigoid. 4. European Congress of Immunology, ECI
European Federation of Immunological Societies (EFIS) (Vienna, Austria)
2015/03 Bullous Pemphigoid: Contribution of IgE Auto-Antibodies to Disease Pathogenesis. 42. Jahrestagung der Arbeitsgemeinschaft Dermatologische Forschung, ADF
ADF (Sociedade de Investigação em Dermatologia - países de língua alemã) (Ulm, Germany)
2015/02 Bullous Pemphigoid: Contribution of IgE Auto-Antibodies to Disease Pathogenesis. Sharing Visions, Joint MCCA-ICA PhD Symposium
(Salzburg, Austria)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016 - 2016 Joint Symposium of the PhD programs IAI (Inflammation and Immunity), CCHD (Cell Communication in Health and Disease), MCCA (Molecular, Cellular and Clinical Allergology) and ICA (Immunity in Cancer and Allergy). (2016 - 2016)
Symposium (Co-organisor)
2015 - 2015 Organização de simpósio conjunto dos programas de doutoramento "Molecular Cellular and Clinical Allergology", da Universidade de Medicina de Viena, e "Immunity in Cancer and Allergy", da Universidade Salzburgo, Áustria. (2015 - 2015)
Symposium (Co-organisor)
Distinctions

Award

2018 Anton Luger Prize (Dissertations of outstanding scientific content in the field of clinical and experimental dermatology)
Österreichische Gesellschaft für Dermatologie und Venerologie, Austria
2017 Heinrich Auspitz Innovation Award (Excellent scientific contributions to the field of Immuno-dermatology)
Österreichische Gesellschaft für Dermatologie und Venerologie, Austria
2017 Poster Prize (PhD Symposium)
Medizinische Universität Wien, Austria
2017 Poster Prize (Young Scientists Association Symposium)
Medizinische Universität Wien, Austria

Other distinction

2016 Travel Grant (Inflammatory Skin Disease Summit)
Icahn School of Medicine at Mount Sinai, United States