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Patricio Soares-da-Silva. Obtained his PhD in Medicine (Physiology and Pharmacology) in 1988/10/17 by University of Porto Faculty of Medicine and a Medical degree in 1981 by University of Porto Faculty of Medicine. Is full professor at University of Porto Faculty of Medicine and director of the PhD Program in Experimental and Clinical Pharmacology and Toxicology at University of Porto. Authored 363 full papers in peer reviewed journals and 9 books. Supervised 10 PhD thesis and co-supervised another 4 PhD thesis. Supervised 4 master thesis. Received 5 awards. Participates and/or participated as Investigator in 1 competitive research project and Principal Investigador in 10 competitive research projects. His main research area is concerned with Medical and Health Sciences with emphasis in Pharmacology and Drug Discovery. In his Ciência Vitae CV the more frequent terms regarding scientific production are: Parkinson’s disease; COMT inhibitors; Hepatotoxicity; Nitrocatechol compounds and heterocycle catechol mimetics; fibrogenesis; ATPase Na+; K+; potassium channels; colitis; TLRs toll-like receptors; NOD2 nucleotide-binding oligomerization domain; Electrolyte transport in intestinal cells; membrane potential; Cardiovascular risk; hypertension; genetic markers; oxidative stress; Arterial hypertension; LAT2; Dopamine; Regulation of expression and function; Na+-independent Cl-/HCO3-; Na+/HCO3- cotransport; Hypertension; Antinatriuretic agents.
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Identification

Personal identification

Full name
Patricio Soares-da-Silva

Citation names

  • Soares-da-Silva, Patricio

Author identifiers

Ciência ID
2A17-D12B-96BF

Email addresses

  • pss@med.up.pt (Professional)

Telephones

Fax
  • 225513643 (Professional)
Telephone
  • 220426700 (Professional)

Addresses

  • Fauldade de Medicina - Universidade do Porto. Unidade de Farmacologia e Terapêutica, Departamento Biomedicina, Faculdade de Medicina do Porto, Al. Prof. Hernani Monteiro, 4200-319, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
1985 - 1988/10/17
Concluded
 Medicina (Doutoramento)
Major in Fisiologia e farmacologia
Universidade do Porto Faculdade de Medicina, Portugal
"Peripheral sympathetic neurotransmission and the role of dopamine on the synthesis and release of norepinephrine" (THESIS/DISSERTATION)
 unanimidade
1976 - 1981
Concluded
 Medicina (Licenciatura)
Universidade do Porto, Portugal
 14 valores
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2009/01/01 - Current Full Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
1999/01/22 - 2008/12/31 Full Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
1997/01/22 - 1999/01/21 Full Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
1992/07/01 - 1997/01/22 Associate Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
1988/12/29 - 1992/06/30 Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
1986/05/02 - 1988/12/28 Assistant (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2016/01/18 - Current Director de Curso de Doutoramento Programa Doutoral em Farmacologia e Toxicologia Experimentais e Clínicas Universidade do Porto Faculdade de Medicina, Portugal
Projects

Contract

Designation Funders
2018/07/26 - 2021/07/25 Development of centrally-active and safe catechol O-methyltransferase inhibitors
PTDC/MED-QUI/29164/2017
Researcher
Universidade do Porto Centro de Investigação Farmacológica e Inovação Medicamentosa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/26 - 2021/07/25 Desenvolvimento de inibidores da catecol O-metiltransferase de acção central sem risco de hepatotoxicidade
PTDC/MED-QUI/29164/2017
Universidade do Porto, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/06/01 - 2020/03/01 Intervenção farmacológica sobre sensores e mecanismos de transporte iónico na fibrose da doença de Crohn
PTDC/DTP-FTO/0735/2014
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Centro de Investigação Farmacológica e Inovação Medicamentosa
UID/BIM/04308/2019
Principal investigator
Universidade do Porto Centro de Investigação Farmacológica e Inovação Medicamentosa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01 - 2019/12 Centro de Investigação Farmacológica e Inovação Medicamentosa
UID/BIM/04308/2019
 Fundação para a Ciência e a Tecnologia
2016/01/01 - 2018/12/31 Centro de Investigação Farmacológica e Inovação Medicamentosa
UID/BIM/4308/2016
Principal investigator
Universidade do Porto Centro de Investigação Farmacológica e Inovação Medicamentosa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/02/01 - 2015/04/30 Efeitos regulatórios exercidos pelos receptores envolvidos no reconhecimento de antigénios microbianos no transporte de eletrólitos e potencial de membrana em células epiteliais intestinais.
PTDC/SAU-TOX/117664/2010
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/02 - 2012/01/01 Oxidative stress and genetic markers of cardiovascular risk in hypertension
PIC/IC/83204/2007
Principal investigator
Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Hospital de São João, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/07/01 - 2008/02/29 Regulação genómica e não-genómica do LAT2 em modelos genéticos de hipertensão
POCI/SAU-OBS/57916/2004
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2007/10/31 Agentes antinatriuréticos e a manipulação renal de bicarbonato na hipertensão
POCI/SAU-FCF/59207/2004
POCI/SAU-FCF/59207/2004
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2003/08/01 - 2006/07/31 Renal tubular vetcorial sodium transport and regulatory mechanisms
POCTI/CBO/45767/2002
Principal investigator
Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002/08 - 2005/07 Study of renal dopaminergic system in heart failure
POCTI/CBO/42788/2001
POCTI/CBO/42788/2001
Principal investigator
Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2000/09/01 - 2003/08/31 Dopamine and sodium handling in immortalised renal tubular epithelial cells from Spontaneous Hypertensive Rats (SHR) and Wistar Kyoto (WKY) rats
POCTI/SAU/35747/FCB/2000
Principal investigator
Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2001/07/25 - 2003/01/24 Papel da dopamina e 5-hidroxitriptamina no metabolismo hidroelectrolítico na doença inflamatória intestinal humana e no rato
POCTI/SAU/14010/2001
Principal investigator
Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Bonifácio, M.J.; Torrão, L.; Loureiro, A.; Fernandes-Lopes, C.; Wright, L.C.; Soares-da-Silva, P.. Pharmacological Profile of Opicapone in Wistar rat. 2013.
    10.1016/B978-0-12-800044-1.00072-6
  2. João Bonifácio, M.; Sutcliffe, J.S.; Torrão, L.; Wright, L.; Soares-da-Silva, P.. Effect of Opicapone, a New Catechol-O-Methyltransferase Inhibitor, in Levodopa Pharmakokinetics in the Cynomolgous Monkey. 2013.
    10.1016/B978-0-12-800044-1.00069-6
  3. Loureiro, A.I.; João Bonifácio, M.; Fernandes-Lopes, C.; Igreja, B.; Pires, N.; Wright, L.; Soares-da-Silva, P.. Pharmacokinetic and Pharmacodynamic Properties of Etamicastat, a New DBH Inhibitor: Comparison to Nepicastat. 2013.
    10.1016/B978-0-12-800044-1.00004-0
  4. Soares-da-Silva, P.. Novel COMT Inhibitors in Parkinson Disease. 2013.
    10.1016/B978-0-12-800044-1.00068-4
  5. Silva, E.; Soares-da-Silva, P.. New Insights into the Regulation of Na +,K +-ATPase by Ouabain. 2012.
    10.1016/B978-0-12-394305-7.00002-1
  6. Learmonth, D.A.; Kiss, L.E.; Soares-da-Silva, P.. The chemistry of catechol-O-methyltransferase inhibitors. 2010.
    10.1016/B978-0-12-381326-8.00006-5
  7. Gomes, P.; Soares-da-silva, P.. Dopamine. 2009.
    10.1002/9783527626236.ch11
  8. Almeida, L.; Bialer, M.; Soares-da-Silva, P.. Eslicarbazepine Acetate. 2009.
    10.1002/9781444316667.ch38
  9. Soares-da-Silva, P.; Vieira-Coelho, M.A.. Nonneuronal Dopamine. 1997.
    10.1016/S1054-3589(08)60884-4
Conference abstract
  1. Mota, F; Moreira, J; Nunes, T; Soares Da Silva, P. "A CLINICAL STUDY METHOD USED TO EVALUATE THE EFFICACY AND SAFETY OF NOVEL ANTIEPILEPTIC DRUG ESLICARBAZEPINE ACETATE IN EPILEPTIC CHILDREN WITH PARTIAL-ONSET SEIZURES". 2012.
  2. Soares Da Silva, P; Hebeisen, S. "SLOW AND FAST INACTIVATION OF VOLTAGE-GATED SODIUM CHANNELS BY ESLICARBAZEPINE AND CARBAMAZEPINE". 2012.
  3. Hebeisen, S; Brady, K; Soares Da Silva, P. "THE EFFECTS OF ESLICARBAZEPINE AND R-LICARBAZEPINE ON SODIUM CURRENTS THROUGH NAV1.7 AND NA(V)1.8 CHANNELS". 2012.
  4. Aires, C; Hebeisen, S; Soares Da Silva, P. "EFFECTS OF ESLICARBAZEPINE, R-LICARBAZEPINE AND OXCARBAZEPINE ON FAST AND SLOW INACTIVATION OF VOLTAGE-GATED SODIUM CHANNELS". 2012.
  5. Ferreira, J; Rocha, JF; Santos, A; Lopes, N; Nunes, T; Soares da Silva, P. "Design of a double-blind, placebo- and active-controlled, phase-III trial in patients with Parkinson's disease and end-of-dose motor fluctuations: opicapone superiority vs. placebo and non-inferiority vs. entacapone". 2012.
  6. Rocha, JF; Nunes, T; Vaz da Silva, M; Machado, R; Wright, L; Falcao, A; Almeida, L; Soares da Silva, P. "Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel COMT inhibitor, during multiple rising dose regimens in healthy male subjects". 2012.
  7. Lees, A; Costa, R; Oliveira, C; Lopes, N; Nunes, T; Soares da Silva, P. "Design of a double-blind, placebo-controlled, phase-III trial in patients with Parkinson's disease and end-of-dose motor fluctuations: opicapone superiority vs. placebo". 2012.
  8. Vaz Da Silva, M; Falcao, A; Nunes, T; Almeida, L; Soares Da Silva, P. "STEADY-STATE PHARMACOKINETICS AND TOLERABILITY OF ONCE-DAILY AND TWICE-DAILY REGIMENS OF ESLICARBAZEPINE ACETATE IN HEALTHY VOLUNTEERS". 2012.
  9. Loureiro, AI; Bonifacio, MJ; Wright, L; Soares Da Silva, P. "THE EFFECTS OF ESLICARBAZEPINE ON RECEPTORS, ION CHANNELS, ENZYMES AND TRANSPORTERS". 2012.
  10. Morte, MI; Carreira, BP; Soares Da Silva, P; Araujo, IM; Carvalho, CM. "ESLICARBAZEPINE DOES NOT ALTER PROLIFERATION AND CELL CYCLE DISTRIBUTION OF NEURAL STEM CELLS ISOLATED FROM THE RAT SUBVENTRICULAR ZONE". 2012.
  11. Falcao, A; Vaz Da Silva, M; Nunes, T; Almeida, L; Soares Da Silva, P. "STEADY-STATE PHARMACOKINETICS AND TOLERABILITY OF ESLICARBAZEPINE ACETATE AND OXCARBAZEPINE IN HEALTHY VOLUNTEERS". 2012.
  12. Bialer, M; Falcao, A; Costa, R; Lopes, N; Nunes, T; Soares Da Silva, P. "ESLICARBAZEPINE ACETATE AND PLASMA LEVELS OF COMBINED ANTIEPILEPTIC DRUGS: A POPULATION PHARMACOKINETICS EVALUATION BASED ON DOUBLE-BLIND PHASE III CLINICAL STUDIES". 2012.
  13. Sousa, RP; Lima, R; Nunes, T; Soares Da Silva, P. "COMPARATIVE BIOAVAILABILITY STUDY OF TWO DIFFERENT SOURCES OF ESLICARBAZEPINE ACETATE IN HEALTHY SUBJECTS". 2012.
  14. Pires, N; Brady, K; Hebeisen, S; Soares Da Silva, P. "THE EFFECTS OF ESLICARBAZEPINE, R-LICARBAZEPINE, OXCARBAZEPINE, AND CARBAMAZEPINE ON SODIUM CURRENTS THROUGH NAV1.2 CHANNELS". 2012.
  15. Moreira, J; Trinka, E; Mota, F; Nunes, T; Soares Da Silva, P. "DESIGN OF A PHASE III, DOUBLE-DUMMY, ACTIVE-CONTROLLED, MULTI-NATIONAL NON-INFERIORITY MONOTHERAPY TRIAL OF ESLICARBAZEPINE ACETATE VERSUS CONTROLLED-RELEASE CARBAMAZEPINE IN ADULTS WITH PARTIAL-ONSET SEIZURES". 2012.
  16. Wright, L; Brady, K; Hebeisen, S; Soares Da Silva, P. "THE EFFECTS OF ESLICARBAZEPINE, R-LICARBAZEPINE, OXCARBAZEPINE AND CARBAMAZEPINE ON SODIUM CURRENTS THROUGH NAV1.3 CHANNELS". 2012.
  17. Nunes, T; Rocha, JF; Falcao, A; Almeida, L; Soares Da Silva, P. "STEADY-STATE PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF ESLICARBAZEPINE ACETATE AND OXCARBAZEPINE IN HEALTHY VOLUNTEERS". 2012.
  18. Lees, A; Costa, R; Oliveira, C; Lopes, N; Nunes, T; Soares da Silva, P. "The design of a double-blind, placebo-controlled, multi-national phase-III trial in patients with Parkinson's disease and end-of-dose motor fluctuations: Opicapone superiority vs. placebo". 2012.
  19. Bonifacio, MJ; Hebeisen, S; Soares Da Silva, P. "EFFECTS OF ESLICARBAZEPINE AND LACOSAMIDE ON SLOW AND FAST INACTIVATION OF VOLTAGE-GATED SODIUM CHANNELS". 2012.
  20. Ferreira, JJ; Rocha, JF; Santos, A; Nunes, T; Soares da Silva, P. "The design of a double-blind, placebo- and active-controlled, multi-national phase-III trial in patients with Parkinson's disease and end-of-dose motor fluctuations: Opicapone superiority vs. placebo and non-inferiority vs. entacapone". 2012.
  21. Versavel, M; Meador, K; Blum, D; Zummo, J; Tripp, K; Soares da Silva, P. "The Incidence of Cognitive Adverse Events Related to Eslicarbazepine Acetate: An Integrated Analysis". 2012.
  22. Versavel, M; Cheng, HL; Blum, D; Zummo, J; Nunes, T; Soares da Silva, P. "Efficacy of Eslicarbazepine Acetate by Type of Concomitantly Used AEDs: An Exploratory Integrated Analysis of Two Phase III Studies". 2012.
  23. Sperling, M; Grinnell, T; Versavel, M; Zummo, J; Blum, D; Soares da Silva, P. "An Investigation of the Incidence and Time to Onset of Adverse Events Associated with Eslicarbazepine Acetate Adjunct Treatment: An Integrated Analysis of Two Double-Blind Placebo-Controlled Trials". 2012.
  24. Blum, D; Grinnell, T; Versavel, M; Zummo, J; Nunes, T; Soares da Silva, P. "Safety of Eslicarbazepine Acetate by Type of Concomitantly Used AEDs: An Exploratory Integrated Analysis of Two Phase III Studies". 2012.
  25. Nunes, T; Rocha, JF; Pinto, R; Machado, R; Wright, L; Falcao, A; Almeida, L; Soares da Silva, P. "Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel COMT inhibitor, during the first administration to healthy male subjects". 2012.
  26. Fernandes Lopes, C; Loureiro, AI; Bonifacio, MJ; Wright, LC; Soares da Silva, P. "A VALIDATED CHIRAL LIQUID-CHROMATOGRAPHY TANDEM MASS-SPECTROMETRY (LC-MS/MS) METHOD FOR THE SEPARATION AND QUANTIFICATION OF ESLICARBAZEPINE ACETATE AND ITS METABOLITES IN HUMAN PLASMA". 2011.
  27. Zummo, J; Blum, D; Versavel, M; Tripp, K; Soares da Silva, P. "An Evaluation of the Effect of Eslicarbazepine Acetate on Weight, Glucose, and Lipids: An Integrated Analysis of Two Double-Blind Phase III Clinical Studies". 2011.
  28. Gil Nagel, A; Lopes Lima, J; Ben Menachem, E; Halasz, P; Versavel, M; Tripp, K; Gama, H; Soares da Silva, P. "AN INTEGRATED DATA ANALYSIS FROM THREE PLACEBO-CONTROLLED CLINICAL STUDIES ON OVER-READ ELECTROCARDIOGRAMS OF EPILEPTIC PATIENTS TREATED WITH ESLICARBAZEPINE ACETATE: ARE THERE ANY EFFECTS ON CARDIAC IMPULSE TRANSMISSION?". 2011.
  29. Igreja, B; Pires, NM; Wright, LC; Soares da Silva, P. "Antihypertensive Effects of a Selective Peripheral Dopamine beta-Hydroxylase Inhibitor Alone or in Combination With Other Antihypertensive Drugs". 2011.
  30. Halasz, P; Ben Menachem, E; Gil Nagel, A; Gabbai, AA; Almeida, L; Moreira, J; Soares da Silva, P. "AN EVALUATION OF EFFICACY AND SAFETY OF ADJUNCTIVE ESLICARBAZEPINE ACETATE IN THREE DOUBLE-BLIND CLINICAL STUDIES ON PATIENTS WITH PARTIAL-ONSET SEIZURES UNSATISFACTORILY TREATED WITH CARBAMAZEPINE". 2011.
  31. Pedrosa, R; Gomes, P; Hopfer, U; Jose, PA; Soares da Silva, P. "Enhanced dopamine D3 receptor-mediated inhibition of the Na+/H+ exchanger in immortalized SHR proximal tubular epithelial cells". 2003.
  32. Pedrosa, R; Gomes, P; Hopfer, U; Jose, PA; Soares Da Silva, P. "Impaired D1-like receptor-mediated inhibition of the Cl-/HCO3-exchanger in immortalized SHR proximal tubular epithelial cells". 2003.
  33. Pinho, MJ; Gomes, P; Serrao, MP; Bonifacio, MJ; Soares da Silva, P. "The onset of hypertension is preceded by overexpression of renal LAT2 and enhanced tubular uptake of dopamine precursor". 2003.
  34. Gomes, P; Soares da Silva, P. "Up-regulation of Na+-K+-ATPase activity in renal OK cells by expression of the alpha1 subunit of the pump". 2003.
  35. Pedrosa, R; Soares da Silva, P. "SHR renal proximal tubules respond to dopamine D3 receptor stimulation with inhibition of the Na+/H+ exchanger". 2003.
  36. Gomes, P; Hopfer, U; Jose, PA; Soares Da Silva, P. "Defective D1-like receptor-mediated inhibition of the C1-/HCO3-exchanger in immortalized SHR proximal tubular epithelial cells". 2003.
  37. Magro, F; Fraga, S; Soares da Silva, P. "IFN-gamma-induced PKC-mediated inhibition of intestinal Na+/H+ exchange activity involves a PKC-MEK-p38 MAPK signaling cascade". 2003.
  38. Gomes, P; Soares da Silva, P. "Dopamine D-2-like receptor-mediated opening of K+ channels in opossum kidney cells". 2003.
  39. Pedrosa, R; Soares da Silva, P. "D-1-mediated inhibition of renal Na+/H+ exchanger through a signalling cascade involving protein G(s)alpha, adenylyl cyclase (AC) and protein kinase A (PKA)". 2003.
  40. Gomes, P; Soares da Silva, P. "Dopamine-mediated inhibition of renal Na+/H+ exchanger isoform 3: Involvement of protein kinase A and C pathways". 2003.
  41. Soares da Silva, P; Pinho, MJ; Serrao, MP. "The L-3,4-dihydroxyphenylalanine transporter in renal epithelial cells is a LAT2/4F2hc hetero amino acid exchanger". 2003.
  42. Soares da Silva, P; Serrao, MP; Gomes, P; Pinho, MJ. "Activity of renal dopaminergic systems in SHR and WKY of 4, 8 and 12 weeks of age on low sodium (LS), normal sodium (NS), and high sodium (HS) intake". 2003.
  43. Magro, F; Fraga, S; Tome Ribeiro, A; Soares Da Silva, P. "Short- and long-term regulation of intestinal Na+/H+ exchanger by IFN-gamma in Caco-2 cells". 2003.
    10.1016/s0016-5085(03)81576-7
  44. Fraga, S; Soares da Silva, P. "D1 receptor-mediated inhibiton of Na plus /H plus exchanger activity in intestinal epithelial IEC-6 cells". 2003.
  45. Soares da Silva, P; Pinho, MJ; Serrao, MP. "L-type amino acid transporter in the renal porcine epithelial cell line LLC-PK1 function as exchanger with neutral amino acids". 2003.
  46. Gomes, P; Jose, PA; Soares da Silva, P. "Up-regulation of Na+-K+-ATPase activity in renal ok cells by expression of the alpha 1 subunit of the pump". 2003.
  47. Pinho, MJ; Bonifacio, MJ; Soares da Silva, P. "Organ specific overexpression of renal LAT2 precedes the onset of hypertension". 2003.
  48. Magro, F; Fraga, S; Tome Ribeiro, A; Soares Da Silva, P. "Role of IFN-gamma on Na+-Na+-ATPase activity in non-inflamed intestinal segments in experimental colitis and its signal transduction". 2003.
    10.1016/s0016-5085(03)81568-8
  49. Soares Da Silva, P; Vieira Coelho, MA; Serrao, MP; Pinho, MJ. "Sensitivity of renal Na+-K+-ATPase activity to dopamine in SHR and WKY of 4 and 12 weeks of age". 2003.
  50. Pinheiro, H; Soares da Silva, P; Alves, J; Torres, L; Moura, D; Guimaraes, S. "The role of several antagonists at pre- and postjunctional angiotensin II receptors in the rat.". 2002.
  51. Fraga, S; Soares Da Silva, P. "L-amino acid transporters and the apical inward and outward transfer of L-DOPA in human and rat intestinal cells". 2002.
  52. Gomes, P; Soares da Silva, P. "Gs alpha protein coupled D1-like receptors stimulate PLC via cAMP-dependent process". 2002.
  53. Gomes, P; Serrao, P; Xu, J; Jose, PA; Soares da Silva, P; Gomes, P.; Xu, J.; et al. "Expression and function of sodium transporters in two opossum kidney cell clonal sublines". 2002.
    10.1152/ajprenal.00340.2001
  54. Gomes, P; Soares da Silva, P. "D-1-like receptors stimulate plc activity in OK cells independent of Gq/11 activation". 2002.
  55. Gomes, P; Soares da Silva, P. "Involvement of multiple signalling pathways during stimulation of renal dopamine D-1-like receptors". 2001.
  56. Sampaio Maia, MB; Serao, P; Soares da Silva, P. "Role of intracellular regulatory pathways upon uptake and handling of L-DOPA by capillary cerebral endothelial cells, astrocytes and neuronal cells". 2001.
  57. Fraga, S; Soares da Silva, P. "L-type amino acid transporter in Caco-2 cells". 2001.
  58. Fraga, S; Soares da Silva, P. "Intestinal epithelial IEC-6 cells are endowed with L-type amino acid transporter". 2001.
  59. Gomes, P; Soares da Silva, P. "Gi protein coupled D-2-like receptors stimulate ATP-sensitive K+ channels through a cyclic AMP-independent pathway in OK cells". 2001.
  60. Vieira Coelho, MA; Gomes, P; Serrao, P; Soares Da Silva, P. "Tolcapone, entacapone and nitecapone stimulate renal D1-like receptors and decrease renal tubular sodium absorption". 2001.
  61. Gomes, P; Vieira Coelho, MA; Soares da Silva, P. "Decreases in Na plus transepithelial flux by dopamine is primarily dependent on inhibition of the apical Na plus /H plus exchanger". 2001.
  62. Calhau, C; Martel, F; Pinheiro Silva, SM; Soares da Silva, P; Hipolito Reis, C; Azevedo, I. "The putative involvement of an ecto-phosphatase on insulin internalization into RBE4 cells.". 2001.
  63. Gomes, P; Soares da Silva, P. "Activation of sequential PKA/PKC signalling pathways during D1-mediated inhibition of renal Na+-K+ ATPase". 2001.
  64. Fraga, S; Soares da Silva, P. "L-type amino acid transporter takes up L-DOPA in intestinal epithelial IEC-6 cells". 2001.
  65. Fraga, S; Soares da Silva, P. "Uptake of L-DOPA by L-type amino acid transporter in Caco-2 cells". 2001.
  66. Gomes, P; Soares da Silva, P. "D-2-like receptors stimulate ATP-sensitive K+ channels through a cAMP-independent pathway in OK cells". 2001.
  67. Calhao, C; Martel, F; Soares da Silva, P; Hipolito Reis, C; Azevedo, I. "Modulation of 3H-MPP+ uptake in RBE4 cells by an ecto-phosphatase activity.". 2001.
  68. Soares da Silva, P; Serrao, MP. "Modulation of inward and outward apical transporters of L-DOPA in LLC-PK1 cells". 2000.
  69. Lucas Teixeira, VA; Vieira Coelho, MA; Serrao, P; Soares da Silva, P. "Sensitivity of intestinal Na+-K+ ATPase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto". 2000.
  70. Maia, MBS; Soares da Silva, P. "Mouse neuroblastoma neuro 2A cells take up L-DOPA through the L-type amino acid transporter". 2000.
  71. Gomes, P; Soares da Silva, P. "Effects of dopamine upon intracellular pH in opossum kidney (OK) cells". 2000.
  72. Maia, MBS; Soares da Silva, P; Sampaio-Maia, B.; Soares-Da-Silva, P.. "Ca2+/calmodulin-mediated pathways regulate the uptake of L-DOPA in mouse neuroblastoma neuro 2A cells". 2000.
    10.1016/S0024-3205(00)00903-6
  73. Gomes, P; Vieira Coelho, MA; Soares da Silva, P. "Inhibition of Na+-K+ ATPase in OK cells by D-1 and D-2 dopamine receptor stimulation". 2000.
  74. Gomes, P; Soares da Silva, P. "Transepithelial flux of sodium and handling of L-DOPA in renal epithelial cells". 2000.
  75. Maia, MBS; Soares Da Silva, P. "Control of luminal uptake of L-dopa at the blood-brain barrier by Ca2+/calmodulin-mediated pathways". 1999.
  76. Damasceno, A; Santos, A; Pestana, M; Serrao, P; Soares da Silva, P; Polonia, J. "Renal dopaminergic system participates in the natriuretic responses to acute sodium load in black salt-resistant but not in salt-sensitive subjects.". 1999.
  77. Gomes, P; Soares Da Silva, P. "Apical L-DOPA-Na+ cotransport and intracellular pH in OK cells". 1999.
  78. Soares da Silva, P; Serrao, P. "Effect of P-glycoprotein substrates and inhibitors on the apical outward transfer of L-DOPA in LLC-PK1 and LLC-GA5 Col300 renal cells". 1999.
  79. Soares da Silva, P; Serrao, P. "Apical uptake of L-DOPA by L-type amino acid transporter in porcine kidney LLC-PK1 cells". 1999.
  80. Vieira Coelho, MA; Serrao, P; Soares da Silva, P. "Ontogenic influences on the regulation of rat intestinal Na+ K+ ATPase by G proteins". 1999.
  81. Vieira Coelho, MA; Soares da Silva, P. "The age-dependent inhibitory effects of dopamine on rat jejunal electrolyte transport and Na-K+ ATPase are mediated through D-1 receptors". 1999.
  82. Soares da Silva, P; Serrao, P. "Ca2+/calmodulin-mediated pathways and the control of apical uptake of L-DOPA in porcine kidney LLC-PK1 cells". 1999.
  83. Soares da Silva, P; Serrao, P. "Sensitivity to UIC2 and verapamil of native and human P-glycoprotein in LLC-PK1 and LLC-GA5 Co1300 renal cells". 1999.
  84. DASILVA, PS. "RENAL NA+-H+ EXCHANGER ACTIVITY, ALPHA-ADRENOCEPTORS AND THE CONTROL OF DOPAMINE OUTFLOW". 1992.
  85. DASILVA, PS. "IS THERE A DOPAMINERGIC VASODILATOR SYSTEM IN THE MESENTERIC ARTERIAL BED". 1986.
Edited book
  1. Soares-da-Silva, Patricio. Cardiovascular and Renal Actions of Dopamine. Oxford, United Kingdom: Pergamon Press. 1993.
    Published • Editor
Journal article
  1. Ana I. Loureiro; Francisco Rocha; Ana T. Santos; Nand Singh; Maria João Bonifácio; Rui Pinto; Laszlo E. Kiss; Patrício Soares-da-Silva. "Absorption, metabolism and excretion of opicapone in human healthy volunteers". British Journal of Clinical Pharmacology (2022): https://doi.org/10.1111/bcp.15383.
    10.1111/bcp.15383
  2. Laura Monni; Larissa Kraus; Matthias Dipper-Wawra; Patricio Soares-da-Silva; Nikolaus Maier; Dietmar Schmitz; Martin Holtkamp; Pawel Fidzinski. "In vitro and in vivo anti-epileptic efficacy of eslicarbazepine acetate in a mouse model of KCNQ2 -related self-limited epilepsy". British Journal of Pharmacology (2022): https://doi.org/10.1111/bph.15689.
    10.1111/bph.15689
  3. Heinz Reichmann; Karla Eggert; Christian Oehlwein; Tobias Warnecke; Andrew J. Lees; Michael Kemmer; Patrício Soares-da-Silva. "Opicapone Use in Clinical Practice across Germany: A Sub-Analysis of the OPTIPARK Study in Parkinson’s Disease Patients with Motor Fluctuations". European Neurology (2022): https://doi.org/10.1159/000523771.
    10.1159/000523771
  4. Luís M. Magalhães; Raquel Costa; Mariana Vieira; Joana Moreira; Helena Gama; Patrício Soares-da-Silva. "Safety of Eslicarbazepine Acetate in Elderly Versus Non-Elderly Patients with Focal Seizures: From Pooled Data of Clinical Studies to 8 Years of Post-Marketing Experience". Drug Safety (2021): https://doi.org/10.1007/s40264-021-01097-5.
    10.1007/s40264-021-01097-5
  5. Tatiana António; Dina Cosme; Bruno Igreja; Sónia Fraga; Maria Paula Serrão; Nuno M. Pires; Patrício Soares-da-Silva. "The role of salt-inducible kinases on the modulation of renal and intestinal Na+,K+-ATPase activity during short- and long-term high-salt intake". European Journal of Pharmacology 904 (2021): 174153-174153. https://doi.org/10.1016/j.ejphar.2021.174153.
    10.1016/j.ejphar.2021.174153
  6. Nuno M. Pires; Bruno Igreja; Patrício Soares-da-Silva. "Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake". Clinical and Experimental Hypertension (2021): 1-8. https://doi.org/10.1080/10641963.2021.1896728.
    10.1080/10641963.2021.1896728
  7. Sarah Schmidt; Leonie Pothmann; Daniel Müller-Komorowska; Thoralf Opitz; Patrício Soares da Silva; Heinz Beck. "Complex effects of eslicarbazepine on inhibitory micro networks in chronic experimental epilepsy". Epilepsia 62 2 (2021): 542-556. https://doi.org/10.1111/epi.16808.
    10.1111/epi.16808
  8. Heinz Reichmann; Andrew Lees; José-Francisco Rocha; Diogo Magalhães; Patrício Soares-da-Silva. "Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study". Translational Neurodegeneration 9 1 (2020): https://doi.org/10.1186/s40035-020-00187-1.
    10.1186/s40035-020-00187-1
  9. Eugen Trinka; Rodrigo Rocamora; João Chaves; Joana Moreira; Fábio Ikedo; Patrício Soares-da-Silva; Conrado Estol; et al. "Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study". Epilepsia (2020): https://doi.org/10.1111/epi.16666.
    10.1111/epi.16666
  10. Maria-João Bonifácio; Filipa Sousa; Cátia Aires; Ana I. Loureiro; Carlos Fernandes-Lopes; Nuno M. Pires; Pedro Nuno Palma; Paul Moser; Patrício Soares-da-Silva. "Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474". British Journal of Pharmacology (2020): https://doi.org/10.1111/bph.14973.
    10.1111/bph.14973
  11. Diogo Nóbrega Catelas; Maria Paula Serrão; Patricio Soares-Da-Silva. "Effects of nepicastat upon dopamine-ß-hydroxylase activity and dopamine and norepinephrine levels in the rat left ventricle, kidney, and adrenal gland". Clinical and Experimental Hypertension (2020): 1-8. https://doi.org/10.1080/10641963.2019.1583245.
    10.1080/10641963.2019.1583245
  12. Verónica Cabreira; Patrício Soares-da-Silva; João Massano. "Contemporary Options for the Management of Motor Complications in Parkinson’s Disease: Updated Clinical Review". Drugs 79 6 (2019): 593-608. https://doi.org/10.1007/s40265-019-01098-w.
    10.1007/s40265-019-01098-w
  13. Takashi Kitajima; Shintaro Mizote; Maria João Bonifácio; Takeo Umemura; Kazuhiro Yoneda; Paul Moser; Patrício Soares-da-Silva; Makoto Tanaka. "Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration". Neuropharmacology 143 (2018): 282-288. https://doi.org/10.1016/j.neuropharm.2018.10.001.
    10.1016/j.neuropharm.2018.10.001
  14. László E. Kiss; Alexandre Beliaev; Humberto S. Ferreira; Carla P. Rosa; Maria João Bonifácio; Ana I. Loureiro; Nuno M. Pires; P. Nuno Palma; Patrício Soares-da-Silva. "Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase". ChemMedChem 13 20 (2018): 2177-2188. https://doi.org/10.1002/cmdc.201800393.
    10.1002/cmdc.201800393
  15. Dominik Holtkamp; Thoralf Opitz; Simon Hebeisen; Patrício Soares-da-Silva; Heinz Beck. "Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells". Epilepsia (2018): https://doi.org/10.1111/epi.14504.
    10.1111/epi.14504
  16. Niklas Michael Beckonert; Thoralf Opitz; Julika Pitsch; Patrício Soares da Silva; Heinz Beck. "Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy". The Journal of Neuroscience (2018): 0640-18. https://doi.org/10.1523/JNEUROSCI.0640-18.2018.
    10.1523/JNEUROSCI.0640-18.2018
  17. Eugen Trinka; José Francisco Rocha; Patrício Soares-da-Silva. "Response: Comparing the dosages of lacosamide, eslicarbazepine acetate, and controlled-release carbamazepine in noninferiority epilepsy monotherapy trials: How much “fair” is “fair”". Epilepsia 59 4 (2018): 900-901. https://doi.org/10.1111/epi.14062.
    10.1111/epi.14062
  18. Christian Elger; Mathias Koepp; Eugen Trinka; Vicente Villanueva; João Chaves; Elinor Ben-Menachen; Pedro A. Kowacs; et al. "Pooled efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Data from four double-blind placebo-controlled pivotal phase III clinical studies". CNS Neuroscience & Therapeutics 23 12 (2017): 961-972. https://doi.org/10.1111/cns.12765.
    10.1111/cns.12765
  19. Alexandre Beliaev; Humberto S. Ferreira; David A. Learmonth; Maria João Bonifácio; Leonel Torrão; Nuno M. Pires; Patrício Soares-da-Silva; László E. Kiss. "Synthesis and structure–activity relationships of ionizable 1,3,4-oxadiazol-2(3H)-ones as peripherally selective FAAH inhibitors with improved aqueous solubility". Pure and Applied Chemistry 88 4 (2016): 341-347. https://doi.org/10.1515/pac-2016-0104.
    10.1515/pac-2016-0104
  20. Igreja, B.; Pires, N.M.; Bonifácio, M.J.; Loureiro, A.I.; Fernandes-Lopes, C.; Wright, L.C.; Soares-Da-Silva, P.. "Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat". Hypertension Research 38 1 (2015): 30-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920541004&partnerID=MN8TOARS.
    10.1038/hr.2014.143
  21. Potschka, H.; Soerensen, J.; Pekcec, A.; Loureiro, A.; Soares-da-Silva, P.. "Effect of eslicarbazepine acetate in the corneal kindling progression and the amygdala kindling model of temporal lobe epilepsy". Epilepsy Research 108 2 (2014): 212-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895075196&partnerID=MN8TOARS.
    10.1016/j.eplepsyres.2013.11.017
  22. Doeser, A.; Soares-da-Silva, P.; Beck, H.; Uebachs, M.. "The effects of eslicarbazepine on persistent Na+ current and the role of the Na+ channel ß subunits". Epilepsy Research 108 2 (2014): 202-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895076823&partnerID=MN8TOARS.
    10.1016/j.eplepsyres.2013.11.022
  23. Bonifácio, M.J.; Sutcliffe, J.S.; Torrão, L.; Wright, L.C.; Soares-Da-Silva, P.. "Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor". Neuropharmacology 77 (2014): 334-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887298369&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2013.10.014
  24. Loureiro, A.I.; Rocha, J.F.; Fernandes-Lopes, C.; Nunes, T.; Wright, L.C.; Almeida, L.; Soares-Da-Silva, P.. "Human disposition, metabolism and excretion of etamicastat, a reversible, peripherally selective dopamine ß-hydroxylase inhibitor". British Journal of Clinical Pharmacology 77 6 (2014): 1017-1026. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901371715&partnerID=MN8TOARS.
    10.1111/bcp.12274
  25. Loureiro, A.I.; João Bonifácio, M.; Fernandes-Lopes, C.; Igreja, B.; Wright, L.C.; Soares-Da-Silva, P.. "Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat". European Journal of Pharmacology 740 (2014): 285-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906542722&partnerID=MN8TOARS.
    10.1016/j.ejphar.2014.07.027
  26. Grunze, H.; Kotlik, E.; Costa, R.; Nunes, T.; Falcão, A.; Almeida, L.; Soares-Da-Silva, P.. "Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: Experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder i". Journal of Affective Disorders 174 (2014): 70-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918498493&partnerID=MN8TOARS.
    10.1016/j.jad.2014.11.013
  27. Rocha, J.F.; Santos, A.; Falcão, A.; Lopes, N.; Nunes, T.; Pinto, R.; Soares-Da-Silva, P.. "Effect of moderate liver impairment on the pharmacokinetics of opicapone". European Journal of Clinical Pharmacology 70 3 (2014): 279-286. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894473758&partnerID=MN8TOARS.
    10.1007/s00228-013-1602-9
  28. Popov, S.; Takemori, H.; Tokudome, T.; Mao, Y.; Otani, K.; Mochizuki, N.; Pires, N.; et al. "Lack of Salt-Inducible Kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake". PLoS ONE 9 4 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899697539&partnerID=MN8TOARS.
    10.1371/journal.pone.0095771
  29. Rocha, J.-F.; Falcão, A.; Santos, A.; Pinto, R.; Lopes, N.; Nunes, T.; Wright, L.C.; Vaz-Da-Silva, M.; Soares-Da-Silva, P.. "Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations". European Journal of Clinical Pharmacology 70 9 (2014): 1059-1071. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906276703&partnerID=MN8TOARS.
    10.1007/s00228-014-1701-2
  30. Gonçalves, D.; Alves, G.; Fortuna, A.; Soares-da-Silva, P.; Falcão, A.. "An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.". The Analyst 138 8 (2013): 2463-2469. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894330921&partnerID=MN8TOARS.
    10.1039/c3an36671e
  31. Loureiro, A.I.; Fernandes-Lopes, C.; Bonifácio, M.J.; Wright, L.C.; Soares-da-Silva, P.. "N-acetylation of etamicastat, a reversible dopamine-ß-hydroxylase inhibitor". Drug Metabolism and Disposition 41 12 (2013): 2081-2086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888623645&partnerID=MN8TOARS.
    10.1124/dmd.113.053736
  32. Almeida, L.; Nunes, T.; Costa, R.; Rocha, J.F.; Vaz-da-Silva, M.; Soares-da-Silva, P.. "Etamicastat, a Novel Dopamine ß-Hydroxylase Inhibitor: Tolerability, Pharmacokinetics, and Pharmacodynamics in Patients With Hypertension". Clinical Therapeutics 35 12 (2013): 1983-1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890309584&partnerID=MN8TOARS.
    10.1016/j.clinthera.2013.10.012
  33. Almeida, L.; Rocha, J.F.; Falcão, A.; Nuno Palma, P.; Loureiro, A.I.; Pinto, R.; Bonifácio, M.J.; et al. "Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-o-methyltransferase inhibitor, in healthy subjects: Prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor". Clinical Pharmacokinetics 52 2 (2013): 139-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877048700&partnerID=MN8TOARS.
    10.1007/s40262-012-0024-7
  34. Pinto, V.; Pinho, M.J.; Soares-Da-Silva, P.. "Renal amino acid transport systems and essential hypertension". FASEB Journal 27 8 (2013): 2927-2938. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881192710&partnerID=MN8TOARS.
    10.1096/fj.12-224998
  35. Elger, C.; Bialer, M.; Falcão, A.; Vaz-Da-Silva, M.; Nunes, T.; Almeida, L.; Soares-Da-Silva, P.. "Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers". Epilepsia 54 8 (2013): 1453-1461. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881177072&partnerID=MN8TOARS.
    10.1111/epi.12242
  36. Fortuna, A.; Alves, G.; Soares-da-Silva, P.; Falcão, A.. "Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models". Epilepsy Research 107 1-2 (2013): 37-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886953855&partnerID=MN8TOARS.
    10.1016/j.eplepsyres.2013.08.013
  37. Cabral, J.M.; Soares-Da-Silva, P.; Magro, F.. "Short- and long-term regulation of intestinal Na+/H+ exchange activity associated with TLR2 receptor activation is independent of nuclear factor-¿b signaling". Journal of Pharmacology and Experimental Therapeutics 346 3 (2013): 453-464. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882421561&partnerID=MN8TOARS.
    10.1124/jpet.113.204602
  38. Nunes, T.; Rocha, J.F.; Falcão, A.; Almeida, L.; Soares-Da-Silva, P.. "Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers". Epilepsia 54 1 (2013): 108-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872068392&partnerID=MN8TOARS.
    10.1111/j.1528-1167.2012.03595.x
  39. Morte, M.I.; Carreira, B.P.; Falcão, M.J.; Ambrósio, A.F.; Soares-da-Silva, P.; Araújo, I.M.; Carvalho, C.M.. "Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons". Toxicology in Vitro 27 8 (2013): 2193-2202. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885692648&partnerID=MN8TOARS.
    10.1016/j.tiv.2013.09.008
  40. Simão, S.; Gomes, P.; Pinho, M.J.; Soares-Da-Silva, P.. "Identification of SLC26A transporters involved in the Cl -/HCO3 - exchange in proximal tubular cells from WKY and SHR". Life Sciences 93 12-14 (2013): 435-440. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884201988&partnerID=MN8TOARS.
    10.1016/j.lfs.2013.07.026
  41. Falcão, A.; Vaz-da-Silva, M.; Gama, H.; Nunes, T.; Almeida, L.; Soares-da-Silva, P.. "Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy women". Epilepsy Research 105 3 (2013): 368-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880038011&partnerID=MN8TOARS.
    10.1016/j.eplepsyres.2013.02.020
  42. Falcão, A.; Pinto, R.; Nunes, T.; Soares-da-Silva, P.. "Effect of repeated administration of eslicarbazepine acetate on the pharmacokinetics of simvastatin in healthy subjects". Epilepsy Research 106 1-2 (2013): 244-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883304674&partnerID=MN8TOARS.
    10.1016/j.eplepsyres.2013.04.009
  43. Gomes, P.; Simão, S.; Lemos, V.; Amaral, J.S.; Soares-Da-Silva, P.. "Loss of oxidative stress tolerance in hypertension is linked to reduced catalase activity and increased c-Jun NH2-terminal kinase activation". Free Radical Biology and Medicine 56 (2013): 112-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872168784&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2012.11.017
  44. Rocha, J.F.; Almeida, L.; Falcão, A.; Palma, P.N.; Loureiro, A.I.; Pinto, R.; Bonifácio, M.J.; et al. "Opicapone: A short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects". British Journal of Clinical Pharmacology 76 5 (2013): 763-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886928771&partnerID=MN8TOARS.
    10.1111/bcp.12081
  45. Afonso, J.; Passos, C.P.; Coimbra, M.A.; Silva, C.M.; Soares-da-Silva, P.. "Inhibitory effect of phenolic compounds from grape seeds (Vitis vinifera L.) on the activity of angiotensin I converting enzyme". LWT - Food Science and Technology 54 1 (2013): 265-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879783227&partnerID=MN8TOARS.
    10.1016/j.lwt.2013.04.009
  46. Hufnagel, A.; Ben-Menachem, E.; Gabbai, A.A.; Falcão, A.; Almeida, L.; Soares-da-Silva, P.. "Long-term safety and efficacy of eslicarbazepine acetate as adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy: Results of a 1-year open-label extension study". Epilepsy Research 103 2-3 (2013): 262-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873081426&partnerID=MN8TOARS.
    10.1016/j.eplepsyres.2012.07.014
  47. Falcão, A.; Lima, R.; Sousa, R.; Nunes, T.; Soares-Da-Silva, P.. "Bioequivalence of eslicarbazepine acetate from two different sources of its active product ingredient in healthy subjects". Drugs in R and D 13 2 (2013): 137-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879734951&partnerID=MN8TOARS.
    10.1007/s40268-013-0016-6
  48. Gil Nagel, A; Elger, C; Ben Menachem, E; Halasz, P; Lopes Lima, J; Gabbai, AA; Nunes, T; et al. "Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Integrated analysis of pooled data from double-blind phase III clinical studies". EPILEPSIA (2013): https://www.authenticus.pt/P-002-1V5.
    10.1111/j.1528-1167.2012.03605.x
  49. Fortuna, A.; Alves, G.; Almeida, A.; Lopes, B.; Falcão, A.; Soares-da-Silva, P.. "A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain". Biomedical Chromatography 26 3 (2012): 384-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856569184&partnerID=MN8TOARS.
    10.1002/bmc.1670
  50. Gonçalves, D.; Alves, G.; Soares-da-Silva, P.; Falcão, A.. "Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: A review". Analytica Chimica Acta 710 (2012): 17-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-84155162415&partnerID=MN8TOARS.
    10.1016/j.aca.2011.10.026
  51. Fortuna, A.; Alves, G.; Falcão, A.; Soares-Da-Silva, P.. "Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique". Epilepsia 53 3 (2012): 529-538. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857546604&partnerID=MN8TOARS.
    10.1111/j.1528-1167.2012.03409.x
  52. Popov, S.; Venetsanou, K.; Jorge Chedrese, P.; Pinto, V.; Takemori, H.; Franco-Cereceda, A.; Eriksson, P.; et al. "Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line". American Journal of Physiology - Heart and Circulatory Physiology 303 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863636917&partnerID=MN8TOARS.
    10.1152/ajpheart.00512.2011
  53. Nuno Palma, P.; João Bonifácio, M.; Isabel Loureiro, A.; Soares-Da-Silva, P.. "Computation of the binding affinities of catechol-O-methyltransferase inhibitors: Multisubstate relative free energy calculations". Journal of Computational Chemistry 33 9 (2012): 970-986. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857452205&partnerID=MN8TOARS.
    10.1002/jcc.22926
  54. Vaz-Da-Silva, M.; Nunes, T.; Almeida, L.; Gutierrez, M.J.; Litwin, J.S.; Soares-Da-Silva, P.. "Evaluation of eslicarbazepine acetate on cardiac repolarization in a thorough QT/QTc study". Journal of Clinical Pharmacology 52 2 (2012): 222-233. http://www.scopus.com/inward/record.url?eid=2-s2.0-81755165629&partnerID=MN8TOARS.
    10.1177/0091270010391789
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  223. Vaz-da-Silva, M.; Hainzl, D.; Almeida, L.; Dolgner, A.; Silveira, P.; Maia, J.; Soares-da-Silva, P.. "Relative bioavailability of two enteric-coated formulations of omeprazole following repeated doses in healthy volunteers". Clinical Drug Investigation 21 3 (2001): 203-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035096528&partnerID=MN8TOARS.
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  224. Gomes, P.; Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "Ouabain-insensitive acidification by dopamine in renal ok cells: Primary control of the Na+/H+ exchanger". American Journal of Physiology - Regulatory Integrative and Comparative Physiology 281 1 50-1 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034809518&partnerID=MN8TOARS.
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  225. Rodrigues, M.L.; Archer, M.; Bonifácio, M.J.; Soares-da-Silva, P.; Carrondo, M.A.. "Crystallization and preliminary crystallographic characterization of catechol-O-methyltransferase in complex with its cosubstrate and an inhibitor". Acta Crystallographica Section D: Biological Crystallography 57 6 (2001): 906-908. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034984640&partnerID=MN8TOARS.
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  226. Vieira-Coelho, M.A.; Gomes, P.; Serrão, M.P.; Soares-da-Silva, P.. "D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors". Kidney International 59 5 (2001): 1683-1694. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744629&partnerID=MN8TOARS.
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  227. Parada, A.; Loureiro, A.I.; Vieira-Coelho, M.A.; Hainzl, D.; Soares-da-Silva, P.. "BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation". European Journal of Pharmacology 420 1 (2001): 27-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035907998&partnerID=MN8TOARS.
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  228. Vieira-Coelho, M.A.; Soares-da-Silva, P.. "Comparative study on sodium transport and Na+,K+-ATPase activity in Caco-2 and rat jejunal epithelial cells: Effects of dopamine". Life Sciences 69 17 (2001): 1969-1981. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035860346&partnerID=MN8TOARS.
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  229. Ambrósio, A.F.; Silva, A.P.; Malva, J.O.; Soares-da-Silva, P.; Carvalho, A.P.; Carvalho, C.M.. "Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels". Biochemical Pharmacology 61 10 (2001): 1271-1275. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035873841&partnerID=MN8TOARS.
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  230. Bonifácio, M.J.; Sheridan, R.D.; Parada, A.; Cunha, R.A.; Patmore, L.; Soares-Da-Silva, P.. "Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: Comparison with carbamazepine". Epilepsia 42 5 (2001): 600-608. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035013202&partnerID=MN8TOARS.
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  231. Bonifácio, M.J.; Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "Expression and characterization of rat soluble catechol-O-methyltransferase fusion protein". Protein Expression and Purification 23 1 (2001): 106-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034817085&partnerID=MN8TOARS.
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  232. Sampaio-Maia, B.; Soares-Da-Silva, P.. "Inhibition of calcium-independent luminal uptake of L-dopa by calmodulin antagonists in immortalized rat capillary cerebral endothelial cells". Cell Biology International 25 3 (2001): 245-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034967850&partnerID=MN8TOARS.
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  233. Johansen, J.E.; Teixeira, V.L.; Johansson, C.; Serrão, P.; Berggren, P.-O.; Soares-Da-Silva, P.; Schalling, M.; Bertorello, A.M.. "Altered dopaminergic transmission in the anorexic anx/anx mouse striatum". NeuroReport 12 12 (2001): 2737-2741. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035964371&partnerID=MN8TOARS.
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  234. Ferreira, A.; Bettencourt, P.; Pestana, M.; Correia, F.; Serrao, P.; Martins, L.; Cerqueira-Gomes, M.; Soares-da-Silva, P.. "Heart failure, aging, and renal synthesis of dopamine". American Journal of Kidney Diseases 38 3 (2001): 502-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034861985&partnerID=MN8TOARS.
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  235. Soares-da-Silva, P.. "Clinical and Experimental Hypertension: Preface". Clinical and Experimental Hypertension 22 3 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034023694&partnerID=MN8TOARS.
  236. Soares-Da-Silva, P.; Serrao, M.P.. "Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK1 cells". American Journal of Physiology - Renal Physiology 279 4 48-4 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0033712281&partnerID=MN8TOARS.
  237. Lucas-Teixeira, V.; Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "Food intake abolishes the response of rat jejunal Na+,K+-ATPase to dopamine". Journal of Nutrition 130 4 (2000): 877-881. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034020621&partnerID=MN8TOARS.
  238. Soares-Da-Silva, P.; Serrão, M.P.. "Outward transfer of dopamine precursor L-3,4-dihydroxyphenylalanine (L- dopa) by native and human P-glycoprotein in LLC-PK1 and LLC-GA5 Col300 renal cells". Journal of Pharmacology and Experimental Therapeutics 293 2 (2000): 697-704. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034099810&partnerID=MN8TOARS.
  239. Lucas-Teixeira, V.; Vieira-Coelho, M.A.; Serrao, M.P.; Soares-Da-Silva, P.. "Food deprivation increases a2-adrenoceptor-mediated modulation of jejunal epithelial transport in young and adult rats". Journal of Nutrition 130 10 (2000): 2461-2466. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033798155&partnerID=MN8TOARS.
  240. Vieira-Coelho, M.A.; Soares-da-Silva, P.. "Ontogenic aspects of D 1 receptor coupling to G proteins and regulation of rat jejunal Na +, K + ATPase activity and electrolyte transport". British Journal of Pharmacology 129 3 (2000): 573-581. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033622023&partnerID=MN8TOARS.
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  241. Vieira-Coelho, M.A.; Serrao, P.; Guimaraes, J.T.; Pestana, M.; Soares-da-Silva, P.. "Concerted action of dopamine on renal and intestinal Na+-K+-ATPase in the rat remnant kidney". American Journal of Physiology - Renal Physiology 279 6 48-6 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034548041&partnerID=MN8TOARS.
  242. Tiago Guimaraes, J.; Soares-da-Silva, P.; Guimaraes, J.T.. "Unusual pattern of ß-phenylethylamine deamination in the rat heart". Neurobiology 8 1 (2000): 109-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033816831&partnerID=MN8TOARS.
  243. Ferreira, A.; Bettencourt, P.; Pestana, M.; Oliveira, N.; Serrao, P.; Maciel, M.J.; Cerqueira-Gomes, M.; Soares-Da-Silva, P.. "Renal synthesis of dopamine in asymptomatic post-infarction left ventricular systolic dysfunction". Clinical Science 99 3 (2000): 195-200. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033816424&partnerID=MN8TOARS.
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  244. Ambrósio, A.F.; Silva, A.P.; Araújo, I.; Malva, J.O.; Soares-da-Silva, P.; Carvalho, A.P.; Carvalho, C.M.. "Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024". European Journal of Pharmacology 406 2 (2000): 191-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034644868&partnerID=MN8TOARS.
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  245. Soares-Da-Silva, P.; Pestana, M.; Ferreira, A.; Damasceno, A.; Polónia, J.; Cerqueira-Gomes, M.. "Renal dopaminergic mechanisms in renal parenchymal diseases, hypertension, and heart failure". Clinical and Experimental Hypertension 22 3 (2000): 251-268. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034065234&partnerID=MN8TOARS.
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  246. Lucas-Teixeira, V.; Serrão, M.P.; Soares-da-Silva, P.. "Effect of salt intake on jejunal dopamine, Na+,K+-ATPase activity and electrolyte transport". Acta Physiologica Scandinavica 168 1 (2000): 225-231. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034052698&partnerID=MN8TOARS.
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  247. Bonifácio, M.J.; Vieira-Coelho, M.A.; Borges, N.; Soares-da-Silva, P.. "Kinetics of rat brain and liver solubilized membrane-bound catechol-O-methyltransferase". Archives of Biochemistry and Biophysics 384 2 (2000): 361-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034672072&partnerID=MN8TOARS.
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  248. Parada, A.; Soares-Da-Silva, P.. "The dopamine antagonist Sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization". Neuropharmacology 39 9 (2000): 1645-1652. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034105115&partnerID=MN8TOARS.
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  249. Soares-da-Silva, P.; Parada, A.; Serrao, P.. "The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase". Brain Research 863 1-2 (2000): 293-297. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034725156&partnerID=MN8TOARS.
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  250. Lucas-Teixeira, V.; Serrão, M.P.; Soares-Da-Silva, P.. "Response of jejunal Na+, K+-ATPase to 5-hydroxytryptamine in young and adult rats: Effect of fasting and refeeding". Acta Physiologica Scandinavica 169 2 (2000): 167-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034073194&partnerID=MN8TOARS.
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  251. Lucas-Teixeira, V.A.; Vieira-Coelho, M.A.; Serrão, P.; Pestana, M.; Soares-Da-Silva, P.. "Salt intake and sensitivity of intestinal and renal NA+-K+ atpase to inhibition by dopamine in spontaneous hypertensive and wistar-kyoto rats". Clinical and Experimental Hypertension 22 5 (2000): 455-469. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033861511&partnerID=MN8TOARS.
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  252. Damasceno, A.; Santos, A.; Serrão, P.; Caupers, P.; Soares-da-Silva, P.; Polónia, J.. "Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects". Journal of Hypertension 17 12 SUPPL. (1999): 1995-2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033499092&partnerID=MN8TOARS.
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  253. Vieira-Coelho, M.A.; Hussain, T.; Kansra, V.; Serrao, M.P.; Guimaraes, J.T.; Pestana, M.; Soares-Da-Silva, P.; Lokhandwala, M.F.. "Aging, high salt intake, and renal dopaminergic activity in Fischer 344 rats". Hypertension 34 4 I (1999): 666-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032699694&partnerID=MN8TOARS.
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  254. Benes, J.; Parada, A.; Figueiredo, A.A.; Alves, P.C.; Freitas, A.P.; Learmonth, D.A.; Cunha, R.A.; Garrett, J.; Soares-Da-Silva, P.. "Anticonvulsant and sodium channel-blocking properties of novel 10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives". Journal of Medicinal Chemistry 42 14 (1999): 2582-2587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566070&partnerID=MN8TOARS.
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  255. Ambrósio, A.F.; Silva, A.P.; Malva, J.O.; Soares-Da-Silva, P.; Carvalho, A.P.; Carvalho, C.M.. "Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists". Neuropharmacology 38 9 (1999): 1349-1359. http://www.scopus.com/inward/record.url?eid=2-s2.0-18244425608&partnerID=MN8TOARS.
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  256. Damascene, A.; Santos, A.; Pestana, M.; Serrão, P.; Caupers, P.; Soares-da-Silva, P.; Polónia, J.. "Acute hypotensive, natriuretic, and hormonal effects of nifedipine in salt-sensitive and salt-resistant black normotensive and hypertensive subjects". Journal of Cardiovascular Pharmacology 34 3 (1999): 346-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032872498&partnerID=MN8TOARS.
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  257. Gomes, P.; Soares-Da-Silva, P.. "L-DOPA transport properties in an immortalised cell line of rat capillary cerebral endothelial cells, RBE 4". Brain Research 829 1-2 (1999): 143-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033594775&partnerID=MN8TOARS.
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  258. Sampaio-Maia, B.; Gomes, R.; Soares-da-Silva, P.. "P-glycoprotein phosphorylation/dephosphorylation and cellular accumulation of L-DOPA in LLC-GA5 col300 cells". Journal of Autonomic Pharmacology 19 3 (1999): 173-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032846628&partnerID=MN8TOARS.
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  259. Vieira-Coelho, M.A.; Soares-da-Silva, P.. "Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase". Brain Research 821 1 (1999): 69-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033528426&partnerID=MN8TOARS.
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  260. Gomes, P.; Soares-Da-Silva, P.. "Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells". Neuropharmacology 38 9 (1999): 1371-1380. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032809060&partnerID=MN8TOARS.
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  261. Borges, N.; Vieira-Coelho, M.A.; Parada, A.; Soares-Da-Silva, P.. "Rat liver catechol-O-methyltransferase kinetics and assay methodology". Journal of Enzyme Inhibition 13 6 (1998): 473-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031737541&partnerID=MN8TOARS.
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  262. Guimarães, J.T.; Vindis, C.; Soares-Da-Silva, P.; Parini, A.. "Molecular and kinetic characterization of monoamine oxidases in the rat heart". Biochemical Society Transactions 26 4 (1998): http://www.scopus.com/inward/record.url?eid=2-s2.0-17644435630&partnerID=MN8TOARS.
  263. Gomes, P.; Soares-da-Silva, P.. "NA+/H+ exchange and L-DOPA handling in OK cells". FASEB Journal 12 5 (1998): http://www.scopus.com/inward/record.url?eid=2-s2.0-4243319251&partnerID=MN8TOARS.
  264. Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "Uptake and intracellular fate of L-DOPA in a human intestinal epithelial cell line: Caco-2". American Journal of Physiology - Cell Physiology 275 1 44-1 (1998): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031872957&partnerID=MN8TOARS.
  265. Augusta Vieira-Coelho, M.; Lucas Teixeira, V.A.; Finkel, Y.; Soares-Da-Silva, P.; Bertorello, A.M.. "Dopamine-dependent inhibition of jejunal Na+-K+-ATPase during high- salt diet in young but not in adult rats". American Journal of Physiology - Gastrointestinal and Liver Physiology 275 6 38-6 (1998): http://www.scopus.com/inward/record.url?eid=2-s2.0-20644454164&partnerID=MN8TOARS.
  266. Soares-Da-Silva, P.; Serrão, M.P.; Vieira-Coelho, M.A.. "Apical and basolateral uptake and intracellular fate of dopamine precursur L-dopa in LLC-PK1 cells". American Journal of Physiology - Renal Physiology 274 2 43-2 (1998): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031989185&partnerID=MN8TOARS.
  267. Soares-da-Silva, P.; Serrão, P.. "P-glycoprotein and L-DOPA cell outward transfer". FASEB Journal 12 5 (1998): http://www.scopus.com/inward/record.url?eid=2-s2.0-33749347634&partnerID=MN8TOARS.
  268. Soares-da-Silva, P.; Vieira-Coelho, M.A.. "Nonneuronal dopamine.". Advances in pharmacology (San Diego, Calif.) 42 (1998): 866-869. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031961675&partnerID=MN8TOARS.
  269. Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "a2-Adrenoceptors mediate the effect of dopamine on adult rat jejunal electrolyte transport". European Journal of Pharmacology 356 1 (1998): 59-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032575380&partnerID=MN8TOARS.
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  270. Soares-da-Silva, P.; Serrão, M.P.; Vieira-Coelho, M.A.; Pestana, M.. "Evidence for the involvement of P-glycoprotein on the extrusion of taken up L-DOPA in cyclosporine A treated LLC-PK1 cells". British Journal of Pharmacology 123 1 (1998): 13-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031974168&partnerID=MN8TOARS.
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  271. Almeida, M.J.; Machado, J.; Vieira Coelho, M.A.; Soares Da Silva, P.; Coimbra, J.. "l-3,4-Dihydroxyphenylalanine (L-DOPA) secreted by oyster (Crassostrea gigas) mantle cells: Functional aspects". Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 120 4 (1998): 709-713. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032436942&partnerID=MN8TOARS.
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  272. Vieira-Coelho, M.A.; Lucas Teixeira, V.; Guimarães, J.T.; Serrão, M.P.; Soares-Da-Silva, P.. "Caco-2 cells in culture synthesize and degrade dopamine and 5- hydroxytryptamine: A comparison with rat jejunal epithelial cells". Life Sciences 64 1 (1998): 69-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032573625&partnerID=MN8TOARS.
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  273. Pestana, M.; Jardim, H.; Afonso, C.; Serrão, P.; Santos, N.; Guerra, L.; Soares-da-Silva, P.. "Renal dopaminergic system in nephrotic syndrome and after remission". Nephrology Dialysis Transplantation 13 10 (1998): 2559-2562. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031684240&partnerID=MN8TOARS.
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  274. Tiago Guimarães, J.; Soares-da-Silva, P.. "The activity of MAO A and B in rat renal cells and tubules". Life Sciences 62 8 (1998): 727-737. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032535945&partnerID=MN8TOARS.
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  275. Gomes, P.; Serrão, M.P.; Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan share the same transporter in Opossum kidney cells". International Journal of Biochemistry and Cell Biology 30 2 (1998): 243-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032571152&partnerID=MN8TOARS.
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  276. Pestana, M.; Jardim, H.; Serrão, P.; Soares-da-Silva, P.; Guerra, L.. "Reduced urinary excretion of dopamine and metabolites in chronic renal parenchymal disease". Kidney and Blood Pressure Research 21 1 (1998): 59-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031780843&partnerID=MN8TOARS.
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  277. Borges, N.; Vieira-Coelho, M.A.; Parada, A.; Soares-Da-Silva, P.. "Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain Catechol-O-methyltransferase". Journal of Pharmacology and Experimental Therapeutics 282 2 (1997): 812-817. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030746313&partnerID=MN8TOARS.
  278. Pestana, M.; Faria, M.S.; Oliveira, J.G.; Baldaia, J.; Santos, A.; Guerra, L.E.; Soares-da-Silva, P.. "Assessment of renal dopaminergic system activity during the recovery of renal function in human kidney transplant recipients". Nephrology Dialysis Transplantation 12 12 (1997): 2667-2672. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030683623&partnerID=MN8TOARS.
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  279. Vieira-Coelho, M.A.; Gomes, P.; Serrao, M.P.; Soares-Da-Silva, P.. "Renal and intestinal autocrine monoaminergic systems: Dopamine versus 5-hydroxytryptamine". Clinical and Experimental Hypertension 19 1-2 (1997): 43-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031050111&partnerID=MN8TOARS.
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  280. Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "Apical and basal uptake of L-dopa and L-5-HTP and their corresponding amines, dopamine and 5-HT, in OK cells". American Journal of Physiology - Renal Physiology 272 5 41-5 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0030826388&partnerID=MN8TOARS.
  281. Guimaräes, J.T.; Soares-Da-Silva, P.. "88 Unusual pattern of ß-phenylethylamine deamination in the rat heart". Biochemical Society Transactions 25 4 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-33745040767&partnerID=MN8TOARS.
  282. Pinto-do-O, P.C.; Chibalin, A.V.; Katz, A.I.; Soares-da-Silva, P.; Bertorello, A.M.. "Short-term vs. sustained inhibition of proximal tubule Na,K-ATPase activity by dopamine: Cellular mechanisms". Clinical and Experimental Hypertension 19 1-2 (1997): 73-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031057630&partnerID=MN8TOARS.
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  283. Gomes, P.; Serrão, M.P.; Vieira-Coelho, M.A.; Soares-da-Silva, P.. "Competitive and non-competitive inhibition of L-3,4-dihydroxyphenylalanine uptake in Opossum kidney cells". European Journal of Pharmacology 332 2 (1997): 219-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030804935&partnerID=MN8TOARS.
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  284. Guimarães, J.T.; Vieira-Coelho, M.A.; Serrão, M.P.; Soares-Da-Silva, P.. "Opossum Kidney (OK) cells in culture synthesize and degrade the natriuretic hormone dopamine: A comparison with rat renal tubular cells". International Journal of Biochemistry and Cell Biology 29 4 (1997): 681-688. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343145721&partnerID=MN8TOARS.
    10.1016/S1357-2725(96)00166-5
  285. Gomes, P.; Serrão, M.P.; Vieira-Coelho, M.A.; Soares-da-Silva, P.. "Opossum kidney cells take up L-DOPA through an organic cation potential-dependent and proton-independent transporter". Cell Biology International 21 4 (1997): 249-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031126688&partnerID=MN8TOARS.
    10.1006/cbir.1997.0142
  286. Barili, P.; Sabbatini, M.; Soares-da-Silva, P.; Amenta, F.. "Dopamine D2-like receptors in the rat kidney: Effect of denervation". European Journal of Pharmacology 334 2-3 (1997): 233-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030609089&partnerID=MN8TOARS.
    10.1016/S0014-2999(97)01185-0
  287. Soares-Da-Silva, P.; Vieira-Coelho, M.A.; Serrão, M.P.. "Uptake of L-3,4-dihydroxyphenylalanine and dopamine formation in cultured renal epithelial cells". Biochemical Pharmacology 54 9 (1997): 1037-1046. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030667360&partnerID=MN8TOARS.
    10.1016/S0006-2952(97)00318-3
  288. Pinto-do-Ó, P.C.; Soares-da-Silva, P.. "Studies on the pharmacology of the inward transport of L-DOPA in rat renal tubules". British Journal of Pharmacology 118 3 (1996): 741-747. http://www.scopus.com/inward/record.url?eid=2-s2.0-8944246321&partnerID=MN8TOARS.
  289. Soares-Da-Silva, P.; Pinto-Do-Ó, P.C.; Bertorello, A.M.. "Antagonistic actions of renal dopamine and 5-hydroxytryptamine: Increase in Na+, K+-ATPase activity in renal proximal tubules via activation of 5-HT1A receptors". British Journal of Pharmacology 117 6 (1996): 1199-1203. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029865749&partnerID=MN8TOARS.
  290. Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "Ontogenic aspects of liver and kidney catechol-O-methyltransferase sensitivity to tolcapone". British Journal of Pharmacology 117 3 (1996): 516-520. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030040182&partnerID=MN8TOARS.
  291. Almeida, M.J.; Moura, G.; Machado, J.; Coimbra, J.; Vilarinho, L.; Ribeiro, C.; Soares-da-Silva, P.. "Amino acid and metal content of Crassostrea gigas shell infested by Polydora sp. in the prismatic layer insoluble matrix and blister membrane". Aquatic Living Resources 9 2 (1996): 179-186. http://www.scopus.com/inward/record.url?eid=2-s2.0-0008495129&partnerID=MN8TOARS.
    10.1051/alr:1996021
  292. Soares-Da-Silva, P.; Vieira-Coelho, M.A.; Pestana, M.. "Antagonistic actions of renal dopamine and 5-hydroxytryptamine: Endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake". British Journal of Pharmacology 117 6 (1996): 1193-1198. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029965409&partnerID=MN8TOARS.
  293. Vieira-Coelho, M.A.; Serrao, M.P.; Soares-da-Silva, P.. "Neither L-arginine nor its decarboxylation product, agmatine, change the conversion of L-DOPA to dopamine in rat renal tubules". Pharmacology Communications 7 3 (1996): 209-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029922718&partnerID=MN8TOARS.
  294. Vieira-Coelho, M.A.; Pestana, M.; Soares-da-Silva, P.. "High sodium intake increases the urinary excretion of L-3,4-dihydroxyphenylalanine but fails to alter the urinary excretion of dopamine and amine metabolites in Wistar rats". General Pharmacology 27 8 (1996): 1421-1427. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030561242&partnerID=MN8TOARS.
    10.1016/S0306-3623(96)00064-X
  295. Soares-da-Silva, P.; Serrão, M.P.; Vieira-Coelho, M.A.. "A comparative study on the synthesis of the natriuretic hormone dopamine in OK and LLC-PK1 cells". Cell Biology International 20 8 (1996): 539-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030221897&partnerID=MN8TOARS.
    10.1006/cbir.1996.0070
  296. Soares-da-Silva, P.; Vieira-Coelho, M.A.; Pestana, M.; Fernandes, M.H.; Guimarães, J.T.. "Ontogeny of the cell outward dopamine transporter in canine renal tissues". Fundamental and Clinical Pharmacology 9 3 (1995): 255-262. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029013968&partnerID=MN8TOARS.
    10.1111/j.1472-8206.1995.tb00293.x
  297. Soares-Da-Silva, P.; Vieira-Coelho, M.A.; Pinto-do, -O.P.C.; Pestana, M.; Bertorello, A.M.. "Studies on the nature of the antagonistic actions of dopamine and 5-hydroxytryptamine in renal tissues". Hypertension Research - Clinical and Experimental 18 SUPPL. 1 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029085773&partnerID=MN8TOARS.
  298. Pinto-Do, -O.P.C.; Soares-Da-Silva, P.. "Effect of lithium and ouabain on the cell inward transport of L-DOPA in rat renal tubules". Pharmacology Communications 6 4 (1995): 327-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029161983&partnerID=MN8TOARS.
  299. Pestana, M.; Vieira-Coelho, M.A.; Pinto-Do, -O.P.C.; Fernandes, M.H.; Soares-Da-Silva, P.; Albino-Teixeira, A.. "Assessment of renal dopaminergic system activity during cyclosporine A administration in the rat". British Journal of Pharmacology 115 8 (1995): 1349-1358. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029082713&partnerID=MN8TOARS.
  300. Guimaraes, J.T.; Vieira-Coelho, M.A.; Soares-Da-Silva, P.. "Inhibitory effects of RO 41-1049, lazabemide and tolcapone on rat jejunal MAO-A, MAO-B and COMT activities". Pharmacology Communications 5 3 (1995): 213-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028938362&partnerID=MN8TOARS.
  301. Soares-da-Silva, P.. "Nature and kinetic characteristics of L-DOPA uptake in rat renal proximal tubules". Amino Acids 8 3 (1995): 265-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029033998&partnerID=MN8TOARS.
    10.1007/BF00806823
  302. Pestana, M.; Soares-Da-Silva, P.. "Effect of type A and B monoamine oxidase selective inhibition by Ro 41-1049 and Ro 19-6327 on dopamine outflow in rat kidney slices". British Journal of Pharmacology 113 4 (1994): 1269-1274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027998156&partnerID=MN8TOARS.
  303. Pestana, M.; Soares-Da-Silva, P.. "Outflow of dopamine and noradrenaline originating from l-DOPA and l-threo-DOPS in rat renal tissues". General Pharmacology 25 5 (1994): 879-885. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027936526&partnerID=MN8TOARS.
    10.1016/0306-3623(94)90090-6
  304. Pestana, M.; Soares-Da-Silva, P.. "The renal handling of dopamine originating from L-DOPA and ¿-glutamyl-L-DOPA". British Journal of Pharmacology 112 2 (1994): 417-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028228759&partnerID=MN8TOARS.
  305. Soares-Da-Silva, P.; Fernandes, M.H.; Pinto-do, -Q.P.C.. "Cell inward transport of L-DOPA and 3-0-methyl-L-DOPA in rat renal tubules". British Journal of Pharmacology 112 2 (1994): 611-615. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028318591&partnerID=MN8TOARS.
  306. Villanueva, M.M.; Soares-da-Silva, P.; Osswald, W.. "Effect of sympathetic denervation on the relaxing responses of rabbit arterial smooth muscle". Journal of Autonomic Pharmacology 14 4 (1994): 275-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028050159&partnerID=MN8TOARS.
    10.1111/j.1474-8673.1994.tb00608.x
  307. Finkel, Y.; Eklöf, A.C.; Granquist, L.; Soares-da-Silva, P.; Bertorello, A.M.. "Endogenous dopamine modulates jejunal sodium absorption during high-salt diet in young but not in adult rats". Gastroenterology 107 3 (1994): 675-679. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028030650&partnerID=MN8TOARS.
    10.1016/0016-5085(94)90114-7
  308. Albino-Teixeira, A.; Soares-Da-Silva, P.. "Isosorbide 5-mononitrate reverses high blood pressure in NG-nitro-l-arginine methyl ester treated rats". General Pharmacology 25 7 (1994): 1329-1336. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028020750&partnerID=MN8TOARS.
    10.1016/0306-3623(94)90155-4
  309. Vieira-Coelho, M.A.; Fernandes, M.H.; Soares-da-Silva, P.. "In vivo effects of the monoamine oxidase inhibitors Ro 41-1049 and Ro 19- 6327 on the production and fate of renal dopamine". Journal of Neural Transmission, Supplement 41 (1994): 365-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028182799&partnerID=MN8TOARS.
  310. Fernandes, M.H.; Soares-da-Silva, P.. "Role of monoamine oxidase and cathecol-O-methyltransferase in the metabolism of renal dopamine". Journal of Neural Transmission, Supplement 41 (1994): 101-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028249229&partnerID=MN8TOARS.
  311. Soares-Da-Silva, P.; Fernandes, M.H.; Pestana, M.. "A comparative study on the synthesis of dopamine in the human, dog and rat kidney". Acta Physiologica Scandinavica 148 3 (1993): 347-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027255382&partnerID=MN8TOARS.
    10.1111/j.1748-1716.1993.tb09566.x
  312. Soares-da-Silva, P.. "Enhanced protein kinase C mediated inhibition of renal dopamine synthesis during high sodium intake". Biochemical Pharmacology 45 9 (1993): 1791-1800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027336525&partnerID=MN8TOARS.
    10.1016/0006-2952(93)90435-Y
  313. Soares-da-Silva, P.; Pestana, M.; Fernandes, M.H.; SOARESDASILVA, P; PESTANA, M; FERNANDES, MH. "Involvement of tubular sodium in the formation of dopamine in the human renal cortex". Journal of the American Society of Nephrology 3 9 (1993): 1591-1599. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027571283&partnerID=MN8TOARS.
  314. Soares-da-Silva, P.. "Renal tubular dopamine outward transfer during Na+-H+ exchange activation by a1- and a2-adrenoceptor agonists". British Journal of Pharmacology 109 2 (1993): 569-576. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027253958&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1993.tb13608.x
  315. Soares-da-Silva, P.. "Kinetic study of the tubular dopamine outward transporter in the rat and dog kidney". British Journal of Pharmacology 109 2 (1993): 577-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027311050&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1993.tb13609.x
  316. Soares-da-Silva, P.; Fernandes, M.H.; Pestana, M.. "Studies on the role of sodium on the synthesis of dopamine in the rat kidney". Journal of Pharmacology and Experimental Therapeutics 264 1 (1993): 406-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027485234&partnerID=MN8TOARS.
  317. Matias, A.; Soares-da-Silva, P.; Azevedo, I.. "Neurotoxicity and induction of fibroblast proliferation by acetaldehyde in the rabbit liver". Journal of Autonomic Pharmacology 13 4 (1993): 275-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027317946&partnerID=MN8TOARS.
    10.1111/j.1474-8673.1993.tb00275.x
  318. Soares-da-Silva, P.. "Preferential decarboxylation of l-threo-3,4-dihydroxyphenylserine in rat renal tissues". General Pharmacology 24 1 (1993): 75-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027513922&partnerID=MN8TOARS.
    10.1016/0306-3623(93)90013-N
  319. Vieira-Coelho, M.A.; Soares-da-Silva, P.. "Dopamine formation, from its immediate precursor 3,4-dihydroxyphenylalanine, along the rat digestive tract". Fundamental and Clinical Pharmacology 7 5 (1993): 235-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027230374&partnerID=MN8TOARS.
  320. SOARESDASILVA, P. "RENAL TUBULAR DOPAMINE OUTWARD TRANSFER DURING NA+-H+ EXCHANGE ACTIVATION BY ALPHA(1)-ADRENOCEPTOR AND ALPHA(2)-ADRENOCEPTOR AGONISTS". BRITISH JOURNAL OF PHARMACOLOGY (1993): https://www.authenticus.pt/P-001-MZN.
  321. Soares-da-Silva, P.. "Actin cytoskeleton, tubular sodium and the renal synthesis of dopamine". Biochemical Pharmacology 44 9 (1992): 1883-1886. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026459939&partnerID=MN8TOARS.
    10.1016/0006-2952(92)90085-W
  322. Soares-da-Silva, P.; Fernandes, M.H.; Albino-Teixeira, A.; Azevedo, I.; Pestana, M.. "Brief transient ischemia induces long-term depletion of norepinephrine without affecting the aromatic amino acid decarboxylase and monoamine oxidase activities in the rat kidney". Journal of Pharmacology and Experimental Therapeutics 260 2 (1992): 902-908. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026576353&partnerID=MN8TOARS.
  323. Garrett, M.C.; Soares-da-Silva, P.. "Increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in Huntington's disease: Evidence for an overactive dopaminergic brain transmission". Journal of Neurochemistry 58 1 (1992): 101-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026513174&partnerID=MN8TOARS.
    10.1111/j.1471-4159.1992.tb09283.x
  324. Soares-da-Silva, P.; Fernandes, M.H.. "Sodium-dependence and ouabain-sensitivity of the synthesis of dopamine in renal tissues of the rat". British Journal of Pharmacology 105 4 (1992): 811-816. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026521684&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1992.tb09062.x
  325. Soares-da-Silva, P.; Fernandes, M.H.. "Effect of a-human atrial natriuretic peptide on the synthesis of dopamine in the rat kidney". British Journal of Pharmacology 105 4 (1992): 869-874. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026606801&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1992.tb09070.x
  326. Soares-da-Silva, P.. "A study on the neuronal and non-neuronal stores of dopamine in rat and rabbit kidney". Pharmacological Research 26 2 (1992): 161-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026806573&partnerID=MN8TOARS.
    10.1016/S1043-6618(05)80129-X
  327. Fernandes, M.H.; Soares-Da-Silva, P.. "Type A and B monoamine oxidase activities in the human and rat kidney". Acta Physiologica Scandinavica 145 4 (1992): 363-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026768824&partnerID=MN8TOARS.
    10.1111/j.1748-1716.1992.tb09376.x
  328. Villanueva, M.M.; Nunes, J.P.; Soares-da-Silva, P.. "Relaxant effects of a-human atrial natriuretic peptide on venous smooth muscle". Journal of Autonomic Pharmacology 11 3 (1991): 139-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025852157&partnerID=MN8TOARS.
    10.1111/j.1474-8673.1991.tb00313.x
  329. Soares-da-Silva, P.; Fernandes, M.H.. "A study on the renal synthesis of dopamine in aged rats". Acta Physiologica Scandinavica 143 3 (1991): 287-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025997075&partnerID=MN8TOARS.
    10.1111/j.1748-1716.1991.tb09234.x
  330. Fernandes, M.H.; Pestana, M.; Soares-da-Silva, P.. "Deamination of newly-formed dopamine in rat renal tissues". British Journal of Pharmacology 102 3 (1991): 778-782. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025969366&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1991.tb12250.x
  331. Soares-da-Silva, P.; Fernandes, M.H.. "Inhibitory effects of guanosine 3':5'-cyclic monophosphate on the synthesis of dopamine in the rat kidney". British Journal of Pharmacology 103 4 (1991): 1923-1927. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025866578&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1991.tb12353.x
  332. Soares-Da-Silva, P.; Fernandes, M.H.. "Regulation of dopamine synthesis in the rat kidney". Journal of Autonomic Pharmacology 10 SUPPL. 1 (1991): http://www.scopus.com/inward/record.url?eid=2-s2.0-0026019719&partnerID=MN8TOARS.
  333. Soares-da-Silva, P.; Fernandes, M.H.. "Synthesis and metabolism of dopamine in the kidney: Effects of sodium chloride, monoamine oxidase inhibitors and a-human atrial natriuretic peptide". American Journal of Hypertension 3 6 II SUPPL (1990): http://www.scopus.com/inward/record.url?eid=2-s2.0-0025114108&partnerID=MN8TOARS.
  334. Soares-Da-Silva, P.; Garrett, M.C.. "A kinetic study of the rate of formation of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain of the rat: Implications for the origin of dopac". Neuropharmacology 29 10 (1990): 869-874. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025037167&partnerID=MN8TOARS.
    10.1016/0028-3908(90)90135-E
  335. Soares-da-Silva, P.; Garrett, M.C.. "Overflow of endogenous dopamine and 3,4-dihydroxyphenylacetic acid from tissues of the rat brain, elicited by electrical stimulation, depolarization by potassium and activation of carrier-mediated release". Neuropharmacology 29 12 (1990): 1151-1159. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025203192&partnerID=MN8TOARS.
    10.1016/0028-3908(90)90039-T
  336. Garrett, M.C.; Soares-Da-Silva, P.. "Role of type A and B monoamine oxidase on the formation of 3,4-dihydroxyphenylacetic acid (DOPAC) in tissues from the brain of the rat". Neuropharmacology 29 10 (1990): 875-879. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025081171&partnerID=MN8TOARS.
    10.1016/0028-3908(90)90136-F
  337. Albino-Teixeira, A.; Matias, A.; Soares-da-Silva, P.; Sarmento, A.; Azevedo, I.. "Effects of sympathetic denervation on liver fibroblasts: Prevention by adenosine". Journal of Autonomic Pharmacology 10 3 (1990): 181-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025132441&partnerID=MN8TOARS.
    10.1111/j.1474-8673.1990.tb00017.x
  338. Caramona, M.M.; Soares-da-Silva, P.. "Evidence for an extraneuronal location of monoamine oxidase in renal tissues". Naunyn-Schmiedeberg's Archives of Pharmacology 341 5 (1990): 411-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025218388&partnerID=MN8TOARS.
  339. Soares-Da-Silva, P.; Fernandes, M.H.. "Inhibition by the putative potassium channel opener pinacidil of the electrically-evoked release of endogenous dopamine and noradrenaline in the rat vas deferens". Naunyn-Schmiedeberg's Archives of Pharmacology 342 4 (1990): 415-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025083306&partnerID=MN8TOARS.
  340. Soares-Da-Silva, P.; Villanueva, M.M.. "The vascular relaxant effects of guanabenz are not mediated by a2-adrenoceptors in rat aortic rings". Journal of Pharmacy and Pharmacology 42 3 (1990): 209-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025041203&partnerID=MN8TOARS.
  341. Fernandes, M.H.; Soares-Da-Silva, P.. "Effects of MAO-A and MAO-B selective inhibitors Ro 41-1049 and Ro 19-6327 on the deamination of newly formed dopamine in the rat kidney". Journal of Pharmacology and Experimental Therapeutics 255 3 (1990): 1309-1313. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025672586&partnerID=MN8TOARS.
  342. Fernandes, M.H.; Soares-da-Silva, P.. "Role of monoamine oxidase A and B in the deamination of newly-formed dopamine in the rat kidney.". Journal of Neural Transmission, Supplement 32 (1990): 155-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025618002&partnerID=MN8TOARS.
  343. SOARESDASILVA, P; Soares-Da-Silva, P.. "THE EFFECTS OF QUINPIROLE AND FENOLDOPAM ON THE POTASSIUM-EVOKED OVERFLOW OF ENDOGENOUS DOPAMINE AND NORADRENALINE IN DOG MESENTERIC-ARTERIES". NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 341 1-2 (1990): 37-42. https://www.authenticus.pt/P-001-S6X.
  344. Soares-da-Silva, P.. "Prospects for treatment of hypertension: interventions at the level of the dopaminergic system". Revista Portuguesa de Cardiologia 7 2 (1988): 191-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023967491&partnerID=MN8TOARS.
  345. Soares-da-Silva, P.. "Further evidence for a noradrenaline-independent storage of dopamine in the dog kidney". Journal of Autonomic Pharmacology 8 2 (1988): 127-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023888417&partnerID=MN8TOARS.
    10.1111/j.1474-8673.1988.tb00176.x
  346. Soares-da-Silva, P.; Azevedo, I.. "Differential effects of 6-hydroxydopamine on the two types of nerve vesicles and dopamine and noradrenaline content in mesenteric arterial vessels". Journal of Autonomic Pharmacology 8 1 (1988): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023918244&partnerID=MN8TOARS.
    10.1111/j.1474-8673.1988.tb00163.x
  347. Soares-Da-Silva, P.; Caramona, M.M.. "Effects of methylene blue on the uptake, release and metabolism of noradrenaline in mesenteric arterial vessels". Journal of Pharmacy and Pharmacology 40 8 (1988): 534-538. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023753249&partnerID=MN8TOARS.
  348. Soares-da-Silva, P.. "Evidence for dopaminergic co-transmission in dog mesenteric arterial vessels". British Journal of Pharmacology 95 1 (1988): 218-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023747627&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1988.tb16567.x
  349. Soares-da-Silva, P.; SOARESDASILVA, P. "Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels". British Journal of Pharmacology 91 3 (1987): 591-599. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023187636&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1987.tb11252.x
  350. SOARESDASILVA, P; Soares-da-Silva, P.. "A COMPARISON BETWEEN THE PATTERN OF DOPAMINE AND NORADRENALINE RELEASE FROM SYMPATHETIC NEURONS OF THE DOG MESENTERIC-ARTERY". BRITISH JOURNAL OF PHARMACOLOGY 90 1 (1987): 91-98. https://www.authenticus.pt/P-001-VCF.
    10.1111/j.1476-5381.1987.tb16828.x
  351. Soares-da-Silva, P.. "Evidence for a non-precursor dopamine pool in noradrenergic neurones of the dog mesenteric artery". Naunyn-Schmiedeberg's Archives of Pharmacology 333 3 (1986): 219-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022492683&partnerID=MN8TOARS.
    10.1007/BF00512932
  352. Bowman, A.; Gillespie, J.S.; Soares-da-Silva, P.. "A comparison of the action of the endothelium-derived relaxant factor and the inhibitory factor from the bovine retractor penis on rabbit aortic smooth muscle.". British Journal of Pharmacology 87 1 (1986): 175-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022644304&partnerID=MN8TOARS.
    10.1111/j.1476-5381.1986.tb10169.x
  353. Azevedo, I.; Soares-da-Silva, P.. "A study of the relationship between dopamine and noradrenaline content and transmural pressure in the mesenteric arteries of the dog". Journal of Autonomic Pharmacology 6 1 (1986): 33-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022637340&partnerID=MN8TOARS.
  354. Caramona, M.M.; Soares-da-Silva, P.. "The effects of chemical sympathectomy on dopamine, noradrenaline and adrenaline content in some peripheral tissues". British Journal of Pharmacology 86 2 (1985): 351-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021930939&partnerID=MN8TOARS.
  355. Soares-da-Silva, P.; Davidson, R.. "Effects of 6-hydroxydopamine on dopamine and noradrenaline content in dog blood vessels and heart. Evidence for a noradrenaline-independent dopamine pool". Naunyn-Schmiedeberg's Archives of Pharmacology 329 3 (1985): 253-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021800184&partnerID=MN8TOARS.
    10.1007/bf00501876
  356. Sarmento, A.; Soares-da-Silva, P.; Azevedo, I.. "Adrenergic mechanisms in modulation of activity of the cell nucleus | MECANISMOS ADRENERGICOS NA MODULACAO DA ACTIVIDADE DO NUCLEO CELULAR". Jornal da Sociedade das Ciencias Medicas de Lisboa 149 1 (1985): 17-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021957770&partnerID=MN8TOARS.
  357. Soares-da-Silva, P.; Azevedo, I.. "Fibroblasts and sympathetic innervation of blood vessels". Blood Vessels 22 6 (1985): 278-285. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022294744&partnerID=MN8TOARS.
  358. Esplugues, J.V.; Caramona, M.M.; Moura, D.; Soares-da-Silva, P.. "Effects of chemical sympathectomy on dopamine and noradrenaline content of the dog gastrointestinal tract". Journal of Autonomic Pharmacology 5 3 (1985): 189-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021994949&partnerID=MN8TOARS.
    10.1111/j.1474-8673.1985.tb00119.x
  359. Moura, D.; Soares-da-Silva, P.. "Drug activation of GABAergic transmission in the central nervous system: benzodiazepines and GABAergic agonists | Activação farmacológica da transmissão GABAérgica no sistema nervoso central: benzodiazepinas e agonistas GABAérgicos.". Acta medica portuguesa 6 2 (1985): 57-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021798325&partnerID=MN8TOARS.
  360. Azevedo, I.; Soares-Da-Silva, P.. "Are fibroblasts adrenergically innervated cells?". Blood Vessels 18 6 (1981): 330-332. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019767895&partnerID=MN8TOARS.
Preprint
  1. Marlene Fonseca; Cheila Ribeiro; Guillermo Fernández; Helena Gama; Luís Magalhães; Sara Carolina Henriques; Nuno Silva; et al. "Effect of zamicastat on blood pressure and heart rate response to cold pressor test: a double-blind, randomised, placebo-controlled study in healthy subjects". 2023. https://doi.org/10.22541/au.170007311.18358983/v1.
    10.22541/au.170007311.18358983/v1

Other

Other output
  1. DOES BRAIN 3,4-DIHYDROXYPHENYLACETIC ACID REFLECT DOPAMINE RELEASE. Journal of Pharmacy and Pharmacology. 1987. SOARESDASILVA, P; Soares-da-Silva, P.. https://www.authenticus.pt/P-001-VB5.
    10.1111/j.2042-7158.1987.tb06958.x
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015 - 2020 Modelling propofol pharmacokinetics and pharmacodynamics during an intravenous anaesthesia guided by bispectral index
Supervisor of Ana Maria Faria Araújo
 Medicina (PhD)
Universidade do Porto, Portugal
2019 - 2019 Effects of salt-inducible kinase 1 (SIK1) ablation on intestinal ion transport modulation
Supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2019 Discovery of cardiovascular benefits from dopamine beta-hydroxylase inhibition
Co-supervisor of Bruno Azevedo Igreja
 Farmacologia e Toxicologia Experimentais e Clínicas (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2018 Differential effects of nepicastat upon dopamine-ß-hydroxilase activity and dopamine and noradrenaline levels in the left ventricle, kidney and adrenal glands of the rat
Supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2018 Pharmacodynamic Evaluation of new Brain and Liver Catechol-O-methyltransferase Inhibitors
Supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2018 Inervação simpática e mecanismos adrenérgicos locais na regulação funcional da córnea
Supervisor of Luís Pedro Caldas Figueira
 Medicina (PhD)
Universidade do Porto, Portugal
2014 - 2014 The Translational Approach between Computational Chemistry and Clinical Expertise in Drug Development
Supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2010 - 2014 Etamicastat, a new dopmanine beta-hydroxylase inhibitor pharmacological characterization
Co-supervisor of Ana Isabel Abrantes Loureiro
 Ciências Farmacêuticas (PhD)
Universidade do Porto, Portugal
2007 - 2012 O papel do stress oxidativo na regulação dos transportadores de aminoácidos renais na hipertensão e no envelhecimento
Supervisor of Vanda Carina Ribeiro Pinto
 Biomedicina (PhD)
Universidade do Porto, Portugal
2005 - 2008 Caracterização psico-social de voluntários saudáveis em ensasios clínicos de farmacologia humanan e sua correlação com os resultados de tolerabilidade e farmacocinética
Supervisor
 Medicina (PhD)
Universidade do Porto, Portugal
2002 - 2008 Caracterização funcional e molecular dos transportadores tubulares renais de L-DOPA na hipertensão arterial
Supervisor
 Biomedicina (PhD)
Universidade do Porto, Portugal
2001 - 2006 Contribuição para o estudo do sistema dopaminérgico intestinal: identificação, caracterização funcional e expressão dos sistemas de transporte do percursor da dopamina e mecanismos de acção da amina
Supervisor of Sónia Alexandra Teixeira Fraga
 Biomedicina (PhD)
Universidade do Porto, Portugal
1998 - 2002 Regulação do fluxo transepitelial de sódio e pH intracelular por monoaminas e precurssores imediatos
Supervisor of António Pedro de Barros Gomes
 Biomedicina (PhD)
Universidade do Porto, Portugal
1998 - 2001 Contribuição para o estudo do sistema dopaminérgico renal na insuficiência cardíaca humana
Co-supervisor of António Luís Trindade Sousa e Lobo Ferreira
 Medicina (PhD)
Universidade do Porto, Portugal
1995 - 2001 Contribuição para o estudo das monoaminoxídases A e B
Supervisor of João Tiago de Sousa Pinto Guimarães
 Medicina (PhD)
Universidade do Porto, Portugal
1996 - 2000 Importância da dopmina e 5-hidroxitriptamina no transporte de electrólitos e água a nível do epitélio jejunal
Supervisor of Vera Alexandra Lucas Teixeira
 Biomedicina (PhD)
Universidade do Porto, Portugal
1995 - 2000 Sistemas monoaminérgicos epiteliais autócrinos e metabolismo hidroelectrólico
Supervisor of Maria Augusta Vieira Coelho
 Medicina (PhD)
Universidade do Porto, Portugal
1990 - 1994 Contribuição para o estudo do sistema dopaminérgico renal
Co-supervisor of Manuel de Jesus Falcão Pestana de Vasconcelos
 Medicina (PhD)
Universidade do Porto, Portugal

Association member

Society Organization name Role
2017/10/07 - Current Oligonucleotide Therapeutic Society associado
2013/10/01 - Current American Society Cell Biology regular membership
2013/01/23 - Current American Society Pharmacology and Experimental Therapeutics regular membership
2005/07/04 - Current American Epilepsy Society Full member
2003 - Current American association for the Advance of Science Full member
2000 - Current British Pharmacological Society Full member
1996 - Current American Heart Association Premium Professional Gold Heart member
1993 - Current American Physiological Society regular membership
1985/12/01 - Current Sociedade Portuguesa de Farmacologia associado
Distinctions

Award

2003 Prémio Delta de Hipertensão
Sociedade Portuguesa de Cardiologia, Portugal
2002 Prémo Gulbenkian de Ciência
Fundação Calouste Gulbenkian, Portugal
2001 Prémio Gonçalves Ferreira de Nutrição/Alimentação
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
1986 1º Prémio Pfizer para Jovens Investigadores

Other distinction

2008 Grande Oficial da Ordem do Infante
Presidência da República Portuguesa, Portugal