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Sara Duarte Silva is a Junior Researcher at the ICVS, under an FCT Scientific Employment Stimulus contract. She holds a BSc in Applied Biology (2006), a MSc in Molecular Genetics (2011) and a PhD in Health Sciences (2015) from the University of Minho. Due to her interest in translational research, she invested on the development and characterization of transgenic mouse models of Machado-Joseph disease (MJD) and established a complete platform setup for drug testing. She has tested pharmacotherapy approaches, contributing for the discovery of new compounds for possible use in MJD. From the studies resulting of these years, she has obtained evidence for the involvement of glucocorticoid receptors (GR) in the pathogenesis of MJD. Although ground-breaking, these studies highlight that there is still a gap in the understanding of the functional meaning of the dysfunctional GR signaling in this context. Therefore, she is currently trying to decipher the relevance of this cellular mechanism dysfunction to the pathogenesis of MJD, using a multi-disciplinary approach. She has secured a total of 295.000€ in funding (personal salary and two international grants as PI or co-PI). She supervised several students, namely MSc (5 to completion) and PhD students (4 ongoing), and several undergraduate students. She is also a member of the Animal Welfare Body of the Life and Health Sciences Research Institute and is part of the teaching staff in several post-graduation courses. She received 6 awards and published a total of 37 original articles (9 of which as first author, 10 as second-author and 1 as last-author) and 2 book chapters summing a h-index of 20.
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Identification

Personal identification

Full name
Sara Duarte Silva
Date of birth
1984/04/17
Gender
Female

Citation names

  • Duarte-Silva, S

Author identifiers

Ciência ID
2A1B-2E83-6D80
ORCID iD
0000-0001-9680-4027

Email addresses

  • sarasilva@med.uminho.pt (Professional)
  • sara.duarte.silva84@gmail.com (Personal)

Telephones

Telephone
  • 253604839 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho; ICVS/3B’s - PT Government Associate Laboratory. Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Exact Sciences - Mathematics - Statistics and Probability
  • Social Sciences - Media and Communications
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Exact Sciences - Mathematics - Statistics and Probability
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2020/01/02 - 2021/04/14
Concluded
 Determining the Efficacy of NLX-112 in a Mouse Experimental Model of Cerebellar Ataxia (Pós-doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/07/01 - 2019/12/31
Concluded
 Role of glial cells in the neurodegenerative process in Machado-Joseph disease (Pós-doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/12/21
Concluded
 Health Sciences (Doutoramento)
Major in Ageing and chronic diseases
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Searching for therapeutic strategies in a mouse model of Machado-Joseph disease: targeting proteostasis " (THESIS/DISSERTATION)
 Very good (maximum)
2007 - 2011/06/17
Concluded
 Molecular Genetics (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"Insights into pathology and neurodegeneration features in Machado-Joseph disease transgenic mouse model" (THESIS/DISSERTATION)
 18 (out of 20)
2007
Concluded
 Applied Biology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Caracterização de um modelo transgénico de ratinho da Doença de Machado-Joseph" (THESIS/DISSERTATION)
 14 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2021 - Current Contracted Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/12/21 - 2021 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/12/21 - 2016/06/30 Researcher (Research) Takeda Cambridge Ltd, United Kingdom
2011/06/01 - 2011/12/31 Research Assistant (Research) Universidade do Minho, Portugal
2010/04/01 - 2011/03/02 Research Assistant (Research) Universidade do Minho, Portugal

Others

Category
Host institution 		Employer
2018/01/20 - Current Member of the Animal Welfare Body (AWB) of ICVS/3Bs Universidade do Minho Escola de Medicina, Portugal
Projects

Grant

Designation Funders
2022/03/01 - Current Dissecting the mechanism of action of TUDCA as a therapeutic for SCA3
926212
Co-Principal Investigator (Co-PI)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 National Ataxia Foundation
Ongoing
2024/09/01 - 2027/08/31 New molecules harnessing targeted protein degradation for the treatment of Machado-Joseph disease
HR24-00578
Researcher
Obra Social La Caixa
Ongoing
2020/01/02 - 2022/08/31 Determining the Efficacy of NLX-112 in a Mouse Experimental Model of Cerebellar Ataxia
ID3624
Post-doc
Department of Defense Medical Examination Review Board
Concluded
2021/03/01 - 2022/06/30 Intermittent fasting as a novel therapeutic strategy for SCAs
NAF_ATC2021
NA
Researcher
Universidade do Minho, Portugal
 National Ataxia Foundation
Ongoing
2020/03/01 - 2022/04/30 Studying the effect of the molecular tweezer CLR01 in a mouse model of SCA3
681194
Principal investigator
Universidade do Minho Escola de Medicina, Portugal

Laboratório Associado ICVS 3B's, Portugal
National Ataxia Foundation
Concluded
2016/07/01 - 2019/06/30 Role of glial cells in the neurodegenerative process in Machado-Joseph disease
grant.Provided by PTCRIS: 142277
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2017/01/02 - 2017/12/31 Testing the therapeutic potential of Mesenchymal Stem Cells and their secretome in an animal model of spinocerebellar ataxia type 3
NAF_PI_PM_2016 (ID1087)
Researcher
Universidade do Minho, Portugal
 National Ataxia Foundation
Concluded
2008/01/01 - 2011/12/31 "Ataxin-3: gain and loss of function in Machado-Joseph disease"
PTDC/SAU-GMG/101572/2008:
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2008/02 - 2011/03 Therapeutic approaches for Machado-Joseph disease: study in a mouse model
Provided by PTCRIS: 64076
Research Fellow
Fundação para a Ciência e a Tecnologia, I.P.
Concluded

Contract

Designation Funders
2021/04/15 - Current Bile acids as a glucocorticoid-replacement therapy: from Spinocerebellar ataxia type 3 findings to other neurological diseases
2020.00685.CEECIND
Researcher
Universidade do Minho, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 ICVS/3B's - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/10/25 - 2023/04/24 MiniSOG optogenetics: Harnessing the temporal and spatial control of neuron-astrocyte signaling to treat depression
EXPL/MED-NEU/0611/2021
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 ICVS/3B's - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 26 - 2011-2012
PEst-C/SAU/LA0026/2011
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2023/04/01 - Current Multitarget small-molecule therapeutics for treatment of dementias and other neurodegenerative diseases
Brain Living Lab – RESOLVE Health program.
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde
Ongoing
Outputs

Publications

Book
  1. Duarte-Silva, S; Maciel, P.. Pharmacological therapies for Machado-Joseph disease. Portugal: Springer. 2018.
    Published • 10.1007/978-3-319-71779-1_19
  2. Duarte-Silva, S.; Maciel, P.; Jalles, A.. Therapeutic strategies for polyQ diseases: from cellular and animal models to the clinic. Portugal: Nova Science Publishers. 2012.
Conference paper
  1. Neves-Carvalho, A; Duarte-Silva, S; Silva, J; Almeida, Bruno; Heeltveld, S; Sotiropoulos, I; Wan Li, K; Heutink, P; Maciel, Patrícia. "Neuronal missplicing and imbalance in tau isoform ratio through atxn3 mediated deubiquitylation: implications for disease". Paper presented in AAIC 2019, 2019.
Conference poster
  1. Guerreiro, S. ; Monteiro-Fernandes, Daniela; Duarte-Silva, S; Maciel, Patrícia. "Characterization of the movement disorder phenotype of a mouse model of Down Syndrome". Paper presented in 5th T21RS International Conference, Rome (Italy), 2024.
  2. Meireles-Costa L; Duarte-Silva, S; Neves-Carvalho, Andreia; Silva, Joana Margarida; Monteiro-Fernandes, Daniela; Correia, Joana Sofia; Rodrigues, Bruno; et al. "ATXN3-mediated deubiquitylation of splicing factors regulates neuronal mRNA splicing and tau isoform ratio ATXN3 regulates SRSF7 levels and Tau ratio". Paper presented in EMBO Workshop: "Proteostasis: From translation to degradation"., 2023.
  3. Oliveira, S.; Pereira-Sousa, J.; Vilasboas-Campos, D.; Ferreira-Lomba, B.; Kirstein, J.; Li, J.; Morimoto, R. I.; et al. "Serotonin as an endogenous regulator of proteostasis: towards mechanism". Paper presented in EMBO Workshop: "Proteostasis: From translation to degradation", 2023.
  4. Cunha-Garcia, Daniela ; Duarte-Silva, S; Maciel, Patrícia. "The skeletal muscle in SCA3: contribution to disease, potential for biomarker development and therapeutic target". Paper presented in Postgraduate Students Retreat MSc or PhD, grab your future, 2023.
  5. Correia, Joana Sofia; Monteiro-Fernandes, Daniela; Guerreiro, Sara R.; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela ; Gomes, Patrícia; Duarte-Silva, S; Maciel, Patrícia. Corresponding author: Maciel, Patrícia. "Assessing the HPA-axis mediated stress responses in a mouse model of SCA3". Paper presented in 11th World Congress of Neuroscience IBRO 2023, 2023.
  6. Nóbrega-Martins, Rita; Guedes, Sofia; Udochukwu, Lucian; Santos, Beatriz; Campos-Marques, Carlos; Silva, Iara; Maciel, Patrícia; et al. "Therapeutical potential of tauroursodeoxycholic acid in stress-related brain pathologies". Paper presented in ISN-ESN 2023 Meeting, 2023.
  7. Ferreira-Fernandes, AR; Meireles-Costa L; Duarte-Silva, S; Neves-Carvalho, Andreia; Almeida, Bruno; Teixeira-Castro, Andreia; Maciel, Patrícia. "Unraveling the ATXN3 interactome: clues on its contribution for physiology and disease". Paper presented in ICVS retreat, 2023.
  8. Duarte-Silva, S; DA SILVA, JORGE D.; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Pereira-Sousa, Joana; Ferreira-Fernandes, AR; Rodrigues, Fernando; et al. "The glucocorticoid receptor as a biomarker and neuronal therapeutic target of a disease-improving bile acid in SCA3/MJD". Paper presented in ICVS retreat, 2023.
  9. DA SILVA, JORGE D.; Duarte-Silva, S; Costa, Marta Daniela; Neves-Carvalho, Andreia; Raposo, Mafalda; Soares-Cunha, Carina; Correia, Joana; et al. "Glucocorticoid Receptor as a Biomarker and Neuronal Therapeutic Target of a Disease-Improving Bile Acid in SCA3/MJD". Paper presented in International Congress for Ataxia Research (ICAR) 2022, 2022.
  10. Correia, Joana Sofia; Monteiro-Fernandes, Daniela; Guerreiro, Sara R.; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela ; Gomes, Patrícia; Duarte-Silva, S; Maciel, Patrícia. Corresponding author: Maciel, Patrícia. "Understanding the relevance of the cerebellar cognitive affective syndrome in SCA3 mice". Paper presented in International Congress for Ataxia Research (ICAR) 2022, 2022.
  11. Ferreira-Lomba, Bruna; Guerreiro, Sara R.; Duarte-Silva, S; Cunha-Garcia, Daniela ; Teixeira-Castro, Andreia; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al. "Motor coordination and balance ameliorated after treatment of the CMVMJD135 mouse model of Spinocerebellar Ataxia Type 3 with befiradol". Paper presented in International Congress for Ataxia Research (ICAR) 2022, 2022.
  12. Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela ; Duarte-Silva, S; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al. "Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease". Paper presented in International Society for Neurochemistry-Asian Pacific Society of Neurochemistry (ISN-APSN) meeting 2022, Honolulu, USA, 2022.
  13. Monteiro-Fernandes, D; Guerreiro, S; Gomes, P; Domingues, AV; Soares-Cunha, C; Coimbra, B; Santos, A; et al. "Defining novel behavioural and neurophysiological features and testing a 5HT1A-targeting therapeutic agent in a clinically relevant mouse model of Rett Syndrome". Paper presented in ISN, 2022.
  14. Ferreira-Lomba, Bruna; Guerreiro, S. ; Cunha-Garcia, Daniela ; Duarte-Silva, S; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al. "Pre- and post-symptomatic treatment with NLX-112 improved the balance and motor coordination of the CMVMJD135 mouse model of Machado-Joseph Disease". Paper presented in Federation of European Neuroscience Societies (FENS) Forum 2022, Paris, France, 2022.
  15. Correia, Joana Sofia; Monteiro-Fernandes, Daniela; Guerreiro, Sara R.; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela ; Gomes, Patrícia; Duarte-Silva, S; Maciel, Patrícia. Corresponding author: Maciel, Patrícia. "Stress resilience in SCA3: study of depression and cognitive comorbidities in a mouse model". Paper presented in Federation of European Neuroscience Societies (FENS) Forum 2022, 2022.
  16. Machado-Sousa, Margarida; Gonçalves, Céline S.; Carvalho-Neves, Andreia; Martins, Eduarda P.; Costa, Liliana; Duarte-Silva, S; Maciel, Patrícia; Costa, Bruno M.. "Role of the ubiquitin hydrolase ATXN3 in glioblastoma: a new tumor suppressor gene?". Paper presented in 5th ASPIC International Congress, 2022.
  17. Guerreiro, S; Ferreira-Lomba, B; Duarte-Silva, S; Cunha-Garcia, D; Teixeira-Castro, A; Kleven, M. S; Vidinha-Mira, A; et al. "NLX-112 improved themotor coordination and balance in a Mouse Experimental Model of Machado-Joseph Disease". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), Coimbra ¿ Portugal., 2021.
  18. Vidinha-Mira, A; Monteiro-Fernandes, D; Guerreiro, S; Cunha-Garcia, D; Ferreira-Lomba, B; Oliveira, S; Silva, J; et al. "Can chronic activation of serotonergic signalling be atherapeutic approach for neurodegenerative diseases?". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), Coimbra ¿ Portugal., 2021.
  19. Barbosa, Marta; Santos, Marta; de Sousa, Nídia; Duarte-Silva, S; Vaz, Ana Rita; António J. Salgado; Brites, Dora. "Intrathecal injection of secretome from anti-miR-124-treated ALS motor neurons in mSOD1 mice shows promise as a therapeutic strategy". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
  20. Vidinha-Mira, A; Monteiro-Fernandes, D; Guerreiro, S; Vieira, C; Cunha-Garcia, D; Ferreira-Lomba, B; Oliveira, S; et al. "Does activation of serotonergic treatment suppressproteotoxicity in mouse models of neurodegenerative diseases?". Paper presented in 16th Young European Scientist (YES) Meeting, Porto - Portugal., 2021.
  21. Vilaça- Ferreira, A.; Duarte-Silva, S; Beltrão, Nuno; Neves-Carvalho, Andreia; Carvalho, Ana Luisa; Maciel, Patrícia. "A comprehensive characterization of the cerebellar (dys)fucntion in Spinocerebellar Ataxia Type 3". Paper presented in XIII Encontro Nacional de Estudantes de Bioquímica, 2021.
  22. Costa, Marta; Pontes, Olívia; Duarte-Silva, S; Gonçalves, Céline S.; Bessa, Carlos; Sampaio-Marques, Belém; Bruno M. Costa; et al. "A new lead compound for triple negative breast cancer therapy". Paper presented in EFMC-ISMC2021, 2021.
  23. Correia, JS; Neves-Carvalho, Andreia; Mendes-Pinheiro, B; Pires, J; Duarte-Silva, S; Monteiro, S; Teixeira, FG; et al. "Testing the Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in an Animal Model of Spinocerebellar Ataxia Type 3". Paper presented in 8th Ataxia Investigators Meeting (AIM) 2021, Virtual event, 2021.
  24. Vidinha-Mira, André; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Almeida, Bruno; Duarte-Silva, S; Maciel, Patrícia; Teixeira-Castro, Andreia. Corresponding author: Vidinha-Mira, André. "Serotonergic Signalling Activation as a Therapeutic Approach for Neurodegenerative Disorders". Paper presented in IJUP¿21 ¿ 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  25. Vidinha-Mira, A; Monteiro-Fernandes, D; Guerreiro, S; Almeida, B; Duarte-Silva, S; Teixeira-Castro, A. "Serotonergic Signalling Activation as a Therapeutic Approach for Neurodegenerative Diseases". Paper presented in IJUP'21 - 14th Young Investigation Meeting of University of Porto, 2021.
  26. Oliveira, S; Duarte-Silva, S; Da Silva, J. D; Cunha-Garcia, D; Esteves, S; Riess, O; Hübener-Schmid, J; Maciel, P; Teixeira-Castro, A. "Towards the molecular determinants of serotonergic signaling-mediated suppression of SCA3 pathogenesis". Paper presented in 8th Ataxia Investigators Meeting (AIM) 2021, Virtual event, 2021.
  27. Duarte-Silva, S. "Glucocorticoid receptor dysfunction as a SCA3/MJD biomarker and target for bile acid therapy". Paper presented in 8th Ataxia Investigators Meeting (AIM), “Leveraging Therapeutic Opportunity into Novel Treatment Paradigms”, 2021.
  28. Correia, J.S.; Monteiro-Fernandes, D; Guerreiro, S; Lomba, B; Cunha-Garcia, D; Gomes, P; Viana, J; Duarte-Silva, S; Maciel, P. "Do MJD mice present a cerebellar cognitive affective syndrome?". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), Coimbra ¿ Portugal., 2021.
  29. Vilaça- Ferreira, A.; Neves-Carvalho, Andreia; Duarte-Silva, S; Maciel, Patrícia. "Neuronal communication in Spinocerebellar Ataxia Type 3: a longitudinal characterization of the synapse". Paper presented in XIX NeRD Annual Retreat, 2020.
  30. Neves-Carvalho, Andreia; Mendes-Pinheiro B.; Correia S. J.; Duarte-Silva, S; Monteiro S.; Teixeira F. G; Lima R.; Salgado A. J.; Maciel P.. "Pre-clinical study of mesenchymal stem cells transplantation and their secretive administration in an animal model of Spinocerebellat ataxia type 3". Paper presented in Ataxia Investigators Meeting, 2020.
  31. Duarte-Silva, S; Teixeira-Castro, A.; Maciel, Patrícia. "Disease-modifying therapies for SCA3: lessons from preclinical trials". Paper presented in International Ataxia Research Conference, 2019.
  32. Cunha-Garcia, Daniela ; Oliveira, João Filipe; Correia, Joana Sofia; Neves-Carvalho, Andreia; Maciel, Patrícia; Duarte-Silva, S. "Impact of astrocytic calcium suppression in the pathogenesis of Machado Joseph disease". Paper presented in Neurosciences annual retreat (ICVS/3B's), 2019.
  33. Teixeira-Castro, A; Oliveira, S; Pereira-Sousa, J; Duarte-Silva, S; Hübener-Schmid, J; Riess, O; Maciel, P. "Serotonergic signaling activation suppresses proteotoxicity". Paper presented in 2019 International Ataxia Research Conference (IARC), Washington DC - USA, 2019.
  34. Duarte-Silva, S; Da Silva JD; Neves-Carvalho, Andreia; Raposo, Mafalda; Soares-Cunha, Carina; Correia, JS; Nogueira-Gonçalves, G; et al. "A Glucorticoid receptor-dependent mechanism of bile acid action with therapeutic impact in polyglutamine disease.". Paper presented in European Behavioral Pharmacology Society, 2019.
  35. Duarte-Silva, S; Campos, AB; Neves-Carvalho, Andreia; Nogueira-Gonçalves, G; Teixeira-Castro, A; Maciel, Patrícia. "Microglial and astrocytic pathology in a mouse model of Machado-Joseph disease". Paper presented in The XIV European Meeting on Glial Cells in Health and Disease, 2019.
  36. Duarte-Silva, S. "In vitro and in vivo evaluation of new chromene derivatives as potent anticancer agents". Paper presented in Porto cancer meeting 2019 & Porto-Bordeaux joint meeting, 2019.
  37. Oliveira, Stéphanie; Esteves, Sofia; Duarte-Silva, S; Cunha-Garcia, Daniela ; Teixeira-Castro, Andreia; Maciel, Patrícia. "Finding molecular determinants supporting serotonergic modulation as a therapeutic approach in Machado Joseph Disease". Paper presented in ICVS Open Day, 2019.
  38. Oliveira, Stephanie; Esteves, S; Duarte-Silva, S; Cunha-Garcia, Daniela; Maciel, Patrícia; Teixeira-Castro, A. "Early modulation of serotonergic signaling suppresses aggregation in Spinocerebellar Ataxia 3". Paper presented in Workshop on "Strategies & tools for modulating pathologic protein self-assembly in proteinopathies, 2019.
  39. Oliveira, Stephanie; Esteves, S; Duarte-Silva, S; Cunha-Garcia, Daniela; Costa, MC; Teixeira-Castro, A; Maciel, Patrícia. "Preclinical evidence supporting serotonergic modulation as a therapeutic approach for Spinocerebellar Ataxia 3". Paper presented in AD/PD 2019 ¿ The 14th International Conference on Alzheimer¿s & Parkinson¿s Diseases, 2019.
  40. Neves-Carvalho, Andreia; Duarte-Silva, S; Almeida, Bruno; Heetveld S; Sotiropoulos I; Heutink P; Wan KL; Maciel, Patrícia. "Regulation of neuronal mRNA splicing and Tau isoform by ATXN3 in Spinocerebellar Ataxia Type-3 transgenic mice and patients.". Paper presented in VIII National RNA Meeting: ptRNA2019, 2019.
  41. Neves-Carvalho A; Duarte-Silva, S; Silva JM; Almeida B; Heetveld S; Sotiropoulos I; Heutink P; Li KW; Maciel P. "Regulation of neuronal mRNA splicing and of Tau isoforms ratio by ATXN3 through deubiquitylation of splicing factors". Paper presented in RNA Meeting: ptRNA2019, Porto, PT, 2019.
  42. Neves-Carvalho A; Palarz K; Duarte-Silva, S; Khodakhah K; Maciel P. "Study of Cerebellar circuits (dys)function in Spinocerebellar Ataxia type 3". Paper presented in EMBO Workshop: From genes to circuits in health and disease, Bangalore, IN, 2019.
  43. Neves-Carvalho, Andreia; Palarz K.; Duarte-Silva, S; Khodakhah K.; Maciel P.. "Cerebellar Dysfunction in Spinocerebellar Ataxia Type 3". Paper presented in Neurosciences Retreat, 2019.
  44. Neves-Carvalho, Andreia; Mendes-Pinheiro B.; Correia S. J.; Pires J.; Duarte-Silva, S; Monteiro S.; Teixeira F. G.; et al. "Pre-clinical study of mesenchymal stem cells transplantation and their secretome administration in an animal model of Spinocerebellar ataxia type 3". Paper presented in International Ataxia Research Conference, 2019.
  45. Neves-Carvalho, Andreia; Mendes-Pinheiro B.; Correia S. J.; Pires J.; Duarte-Silva, S; Monteiro S.; Teixeira F. G.; et al. "Testing the therapeutical potential of mesenchymal stem cells and their secretome in an animal model of SCA3". Paper presented in EMBO workshop: from genes to disease, 2019.
  46. Neves-Carvalho, Andreia; Mendes-Pinheiro, B; Correia, SJ; Pires, J; Duarte-Silva, S; Monteiro, S; Teixeira, FG; et al. "Testing the therapeutic potential of mesenchymal stem cells and their secretome in an animal model of SCA3". Paper presented in EMBO workshop: from genes to disease, 2019.
  47. Duarte-Silva, S; Neves-Carvalho A; Silva JM; Silva-Fernandes A; Maciel P. "Neuroprotective effects of creatine in the CMVMJD135 mouse model of spinocerebellar ataxia type 3". Paper presented in 7th Ataxia Investigators Meeting, (AIM), Philadelphia, US, 2018.
  48. Duarte-Silva, S; Neves-Carvalho, Andreia; Nogueira-Gonçalves G; Gomes A; Da Silva J; Silva-Fernandes A; Teixeira-Castro A; Maciel P. "TUDCA, a bile acid, improves the phenotype of Machado-Joseph disease models". Paper presented in Workshop Integrative Approaches in Neurodegeneration, Lisbon, PT, 2018.
  49. Duarte-Silva, S; Neves-Carvalho A; Nogueira-Gonçalves G; Gomes A; Silva-Fernandes A; Teixeira-Castro A; Maciel P. "Neuroinflammation assessment in a transgenic mouse model of Machado-Joseph disease". Paper presented in XV Portuguese Society for Neurosciences, Braga, PT, 2017.
  50. Ashraf N.S; Duarte-Silva, S; Maciel P; Paulson HL; Teixeira-Castro A; Costa MC. "Citalopram reduces aggregation of ATXN3 in a YAC transgenic mouse model of Machado-Joseph disease". Paper presented in International Ataxia Research Conference, Pisa, IT, 2017.
  51. Duarte-Silva, S; Neves-Carvalho A; Nogueira-Gonçalves G; Silva-Fernandes A; Teixeira-Castro A; Maciel P. "Time and region-specific glial pathology in mouse model of Machado-Joseph disease". Paper presented in International Ataxia Research Conference, Pisa, IT, 2017.
  52. Teixeira-Castro, A.; Jalles, A.; Esteves, S.; Santos, LS.; Oliveira, S.; Duarte-Silva, S.; Morimoto, RI.; et al. "Serotonergic signaling suppresses ataxin-3 proteotoxicity". Paper presented in AtaxiaUK, 2017.
  53. Oliveira, Stéphanie; Duarte-Silva, S; Esteves, Sofia; Cunha-Garcia, Daniela ; Maciel, Patrícia; Carvalho, A L; Teixeira-Castro, Andreia. "Serotonergic modulation of the proteostasis network and glutamatergic neurotransmission: impact on MJD". Paper presented in Neurosciences annual retreat (ICVS/3B's), 2017.
  54. Duarte-Silva, S; Neves-Carvalho A; Silva JM; Silva-Fernandes A; Maciel P. "Creatine food supplementation improves the phenotype and delays disease onset of the CMVMJD135 mouse model of Machado-Joseph disease.". Paper presented in 10th World Congress on Controversies in Neurology (CONy), Lisbon, PT, 2016.
  55. Duarte-Silva, S; Neves-Carvalho A; Silva JM; Silva-Fernandes A; Maciel P. "Creatine-supplemented diet delays disease onset and improves the overall phenotype of the CMVMJD135 mouse model of MJD". Paper presented in 6th Ataxia Investigators Meeting, (AIM), Orlando, Florida, US, 2016.
  56. Duarte-Silva, S; Neves-Carvalho A; Nogueira-Gonçalves G; Gomes A; Silva-Fernandes A; Maciel P. "TUDCA improves motor symptoms and reduces neuroinflammation in a transgenic mouse model of Machado-Joseph disease". Paper presented in XIX National Congress of Biochemistry (SPB2016), Guimarães, PT, 2016.
  57. Duarte-Silva, S; Neves-Carvalho A; Silva-Fernandes A; Maciel P. "TUDCA improves motor symptoms and reduces neuroinflammation in a transgenic mouse model of Machado-Joseph disease". Paper presented in XIV of the Portuguese Society for Neurosciences, Póvoa de Varzim, PT, 2015.
  58. Duarte-Silva, S; Neves-Carvalho A; Silva-Fernandes A; Maciel P. "TUDCA reduces neuroinflammation and improves motor symptoms in a transgenic mouse model of Machado-Joseph disease". Paper presented in International MJD conference, Cairns, AU, 2015.
  59. Duarte-Silva, S; Neves-Carvalho A; Silva-Fernandes A; Maciel P. "Combined therapy with m-TOR-dependent and –independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.". Paper presented in International MJD conference, Cairns, AU, 2015.
  60. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Soares-Cunha C; Teixeira-Castro A; Maciel P. "Lithium Chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease". Paper presented in Ataxia Investigators Meeting, Las Vegas, US, 2014.
  61. Duarte-Silva, S; Neves-Carvalho A; Silva-Fernandes A; Maciel P. "Testing Tauroursodeoxycholic Acid, a bile acid with neuroprotective action, in a mouse model of Machado-Joseph disease". Paper presented in Portuguese Society of Biochemistry, Coimbra, PT, 2014.
  62. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Amorim M; Soares-Cunha C; Oliveira P; Teixeira-Castro A; Maciel P. "17-DMAG induces autophagy and delays disease progression in a mouse model of Machado-Joseph disease". Paper presented in Neuroscience Portuguese Society, Luso, Portugal, 2013.
  63. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Soares-Cunha C; Teixeira-Castro A; Maciel P. "Autophagy induction as a therapeutic target for Machado-Joseph disease: 17-DMAG and lithium chloride". Paper presented in XXXVIII Jornadas Portuguesas de Genética, 2013.
  64. Neves-Carvalho A; Martins A; Freitas A; Logarinho E; Duarte-Silva, S; Heutink P; Relvas JB; Maciel P. "Ataxin-3 deubiquitylase contributes to neuronal differentiation through the modulation of alpha-5 integrin levels". Paper presented in XXII Meeting of the Portuguese Society of Neurosciences, Luso, PT, 2013.
  65. Neves-Carvalho A; Martins A; Freitas A; Logarinho E; Duarte-Silva, S; Heutink P; Relvas JB; Maciel, P. "Loss of function of the deubiquitylase Ataxin-3 reduces alpha-5 integrin subunit levels and leads to an abnormal neuronal differentiation process". Paper presented in XXXVIII Portuguese Meeting of Genetics, Porto, PT, 2013.
  66. Neves-Carvalho A; Freitas A; Duarte-Silva, S; Silva-Fernandes A; Martins M; Logarinho E; Heutink P; Relvas JB; Maciel P. "Loss of function of the deubiquitylase Ataxin-3 affects differentiation, proliferation and cytoskeletal organization in neuronal cells through the modulation of alpha-5 integrin subunit levels". Paper presented in 5th Annual Ubiquitin Drug Discovery & Diagnostics, Philadelphia, US, 2013.
  67. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Teixeira-Castro A; Maciel P. "Lithium treatment does not ameliorate the phenotype of a new transgenic mouse model of Machado-Joseph". Paper presented in Mouse Models of Disease – linking in vivo observations to pathology endpoints, Cambridge, UK, 2012.
  68. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Teixeira-Castro A; Maciel P. "17-DMAG, an Hsp90 inhibitor, improves the motor phenotype and neuropathology of a transgenic mouse model of Machado-Joseph disease". Paper presented in 16ª Meeting of the Human Genetics Society, Porto, PT, 2012.
  69. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Teixeira-Castro A; Maciel P. "Lithium treatment does not ameliorate the phenotype of a new transgenic mouse model of Machado-Joseph". Paper presented in Ataxia Investigator meeting (AIM), San Antonio, Texas, US, 2012.
  70. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Teixeira-Castro A; Maciel P. "17-DMAG, an Hsp90 inhibitor, improves the phenotype of a new transgenic mouse model of Machado-Joseph disease". Paper presented in Drugs and the Brain: an update in psychophamacology from experimental to clinic, Braga, PT, 2012.
  71. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Soares-Cunha C; Teixeira-Castro A; Maciel P. "Lithium treatment does not ameliorate the phenotype of a new transgenic mouse model of Machado-Joseph". Paper presented in 6th National Meeting on Cell Signaling (SINAL), Braga, PT, 2012.
  72. Duarte-Silva, S; Esteves S; Silva-Fernandes A; Neves-Carvalho A; Teixeira-Castro A; Maciel P. "17-DMAG and Valproic Acid improve the phenotype of a new transgenic mouse model of Machado-Joseph disease". Paper presented in Ataxia Research Conference (ARC), London, UK, 2012.
  73. Silva-Fernandes A; Duarte-Silva, S; Coppola G; Neves-Carvalho A; Rodrigues AJ; Marques F; H. Geschwind H ; Maciel P. "Region-specific transcriptomic profile alterations in a new transgenic mouse model of Machado-Joseph disease". Paper presented in 15ª Meeting of the Human Genetics Portuguese Society, Lisbon, PT, 2011.
  74. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Teixeira-Castro A; Maciel P. "A novel transgenic mouse model of Machado-Joseph disease: genetic, phenotypic and pathologic similarities with the human disease". Paper presented in International congress of Human Genetics, Montrèal, CA, 2011.
  75. Silva-Fernandes A; Duarte-Silva S; Costa MC; Maciel P. "CAG tract length modulates the severity of symptoms in a transgenic mouse model of MJD/SCA3". Paper presented in 7th FENS – Forum European Neuroscience, Amsterdam, NL, 2010.
  76. Duarte-Silva, S; Silva-Fernandes A; Costa MC; Maciel P. "No evidence for apoptosis or necrosis in spite of neurodegeneration in a transgenic mouse model of MJD/SCA3". Paper presented in Jornadas Portuguesas de Genética, Braga, PT, 2010.
  77. Duarte-Silva, S; Silva-Fernandes A; Neves-Carvalho A; Teixeira-Castro A; Maciel P. "A novel transgenic mouse model of Machado-Joseph disease: autophagy as a potential therapeutical approach". Paper presented in Neurodegenerative diseases: biology & therapeutics, Cold Spring Harbor, NY, US, 2010.
  78. Duarte-Silva, Sara; Silva ; Costa MC; Maciel P. "Aging, Genetic Background and parental gender modulate the CAG repeat instability pattern in a transgenic mouse model of Machado-Joseph disease". Paper presented in International workshop on Machado-Joseph disease, Azores, PT, 2009.
  79. Silva-Fernandes A; Costa MC; Duarte-Silva S; Teixeira-Castro A; Cerqueira JJ; Maciel P. "Motor impairment and brain pathology in a transgenic mouse model of Machado-Joseph disease". Paper presented in Annual meeting of the Society for Neuroscience, Washington US, 2008.
  80. Silva-Fernandes A; Teixeira-Castro A; Costa MC; Duarte-Silva S; Saraiva MJ; Maciel P. "Genetic interaction between Machado-Joseph disease mutant gene and age-related cellular quality control mechanisms". Paper presented in Link-Age Meeting, Porto, PT, 2007.
Journal article
  1. Ribeiro, Miguel; Campos, Jonas; Pinho, Tiffany S.; Sampaio-Marques, Belém; Barata-Antunes, Sandra; Cibrão, Jorge Ribeiro; Araújo, Ricardo; et al. "Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions". Biotechnology Journal 19 7 (2024): http://dx.doi.org/10.1002/biot.202400068.
    10.1002/biot.202400068
  2. Duarte-Silva, S; DA SILVA, JORGE D.; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Neves-Carvalho, Andreia; Mafalda Raposo; Soares-Cunha, Carina; et al. "Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3". The Journal of Clinical Investigation 134 5 (2024): https://doi.org/10.1172/JCI162246.
    Published
  3. Bárbara Mendes-Pinheiro; Jonas de Oliveira Campos; Ana Marote; Carina Soares-Cunha; Sarah L. Nickels; Anna S. Monzel; Jorge Ribeiro; et al. "Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration". Cells (2023): https://www.mdpi.com/2073-4409/12/21/2565.
    10.3390/cells12212565
  4. Filipa Almeida; Ildete L. Ferreira; Luana Naia; Daniela Marinho; Ana Catarina Vilaça-Ferreira; Marta D. Costa; Sara Duarte-Silva; Patrícia Maciel; A. Cristina Rego. "Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado–Joseph Disease". Cells (2023): https://doi.org/10.3390/cells12192397.
    10.3390/cells12192397
  5. Daniela Cunha-Garcia; Daniela Monteiro-Fernandes; Andreia Neves-Carvalho; Ana Catarina Vilaça-Ferreira; Sónia Guerra-Gomes; João Filipe Viana; João Filipe Oliveira; et al. "Genetic Ablation of Inositol 1,4,5-Trisphosphate Receptor Type 2 (IP3R2) Fails to Modify Disease Progression in a Mouse Model of Spinocerebellar Ataxia Type 3". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/13/10606.
    10.3390/ijms241310606
  6. Ana Cristina Rodrigues; Lígia Costa; Ricardo Silva-Carvalho; Renato Mota; Sara Duarte-Silva; Andreia Teixeira-Castro; Nuno Lamas; et al. "Assessment of the gastrointestinal fate of bacterial nanocellulose and its toxicological effects after repeated-dose oral administration". Environmental Science: Nano (2023): http://dx.doi.org/10.1039/d2en01019d.
    10.1039/d2en01019d
  7. Correia, Joana Sofia; Duarte-Silva, Sara; Salgado, Antonio Jose; Maciel, Patricia. "Cell-based therapeutic strategies for treatment of spinocerebellar ataxias: an update". Neural Regeneration Research (2023): https://publons.com/wos-op/publon/56321714/.
    10.4103/1673-5374.355981
  8. Marta Barbosa; Marta Santos; Nídia de Sousa; Sara Duarte-Silva; Ana Rita Vaz; António J. Salgado; Dora Brites. "Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice". Biomedicines (2022): https://doi.org/10.3390/biomedicines10092120.
    10.3390/biomedicines10092120
  9. Kristin Mayoral-Palarz; Andreia Neves-Carvalho; Sara Duarte-Silva; Daniela Monteiro-Fernandes; Patrícia Maciel; Kamran Khodakhah. "Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3". Disease Models & Mechanisms (2022): https://doi.org/10.1242/dmm.049514.
    10.1242/dmm.049514
  10. Campos, Ana Bela; Duarte-Silva, Sara; Fernandes, Bruno; das Neves, Sofia Pereira; Marques, Fernanda; Teixeira-Castro, Andreia; Neves-Carvalho, Andreia; et al. "Profiling Microglia in a Mouse Model of Machado–Joseph Disease". Biomedicines 10 2 (2022): 237. http://dx.doi.org/10.3390/biomedicines10020237.
    10.3390/biomedicines10020237
  11. Campos, A.B.; Duarte-Silva, S.; Fernandes, B.; Coimbra, B.; Campos, J.; Monteiro-Fernandes, D.; Teixeira-Castro, A.; Ambrósio, A.F.; Maciel, P.. "Microglial Depletion Has No Impact on Disease Progression in a Mouse Model of Machado–Joseph Disease". Cells 11 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85132547518&partnerID=MN8TOARS.
    10.3390/cells11132022
  12. Correia, Joana Sofia; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela; Gomes, Patricia; Duarte-Silva, Sara; Maciel, Patricia. "The study of depression and cognitive comorbidities in a mouse model of spinocerebellar ataxia type 3". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/56321719/.
  13. Monteiro-Fernandes, Daniela; Guerreiro, Sara; Gomes, Ana; Domingues, Ana Veronica; Soares-Cunha, Carina; Coimbra, Barbara; Santos, Alexandre; et al. "Integration of behavior and neuronal physiology in a mouse model of Rett Syndrome: a focus on serotonergic system modulation". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/56321718/.
  14. Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela; Duarte-Silva, Sara; Teixeira--Castro, Andreia; Vilasboas-Campos, Daniela; Vidinha-Mira, Andre; et al. "Pre-clinical study of a 5HT1A specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/56321717/.
  15. Vilasboas-Campos, Daniela; Duarte-Silva, Sara; Monteiro-Fernandes, Daniela; Pereira-Sousa, Joana; Neves-Carvalho, Andreia; Bitan, Gal; Macedo-Ribeiro, Sandra; et al. "The molecular tweezer CLR01 reduces motor impairments and neuropathology in spinocerebellar ataxia type 3 in vivo models". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/54883390/.
  16. Correia, Joana Sofia; Neves-Carvalho, Andreia; Mendes-Pinheiro, Bárbara; Pires, Joel; Teixeira, Fábio Gabriel; Lima, Rui; Monteiro, Susana; et al. "Preclinical Assessment of Mesenchymal-Stem-Cell-Based Therapies in Spinocerebellar Ataxia Type 3". Biomedicines 9 12 (2021): 1754. http://dx.doi.org/10.3390/biomedicines9121754.
    10.3390/biomedicines9121754
  17. Mendes-Pinheiro, Bárbara; Soares-Cunha, Carina; Marote, Ana; Loureiro-Campos, Eduardo; Campos, Jonas; Barata-Antunes, Sandra; Monteiro-Fernandes, Daniela; et al. "Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response". International Journal of Molecular Sciences 22 21 (2021): 11530. http://dx.doi.org/10.3390/ijms222111530.
    10.3390/ijms222111530
  18. Mendes, M.O.; Rosa, A.I.; Carvalho, A.N.; Nunes, M.J.; Dionísio, P.; Rodrigues, E.; Costa, D.; et al. "Corrigendum to Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy¿ [Mol. Cell. Neurosci., Volume 96, April 2019, Pages 1¿9.](S1044743118303907)(10.1016/j.mcn.2019.01.003)". Molecular and Cellular Neuroscience (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105752069&partnerID=MN8TOARS.
    10.1016/j.mcn.2021.103626
  19. Neves-Carvalho, Andreia; Duarte-Silva, Sara; Teixeira-Castro, Andreia; Maciel, Patrícia. "Polyglutamine spinocerebellar ataxias: emerging therapeutic targets". Expert Opinion on Therapeutic Targets (2020): 1-21. http://dx.doi.org/10.1080/14728222.2020.1827394.
    10.1080/14728222.2020.1827394
  20. Monteiro, Susana; Pinho, Andreia G.; Macieira, Mara; Serre-Miranda, Cláudia; Cibrão, Jorge R.; Lima, Rui; Soares-Cunha, Carina; et al. "Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord". Journal of Neuroinflammation 17 1 (2020): http://dx.doi.org/10.1186/s12974-020-01945-8.
    10.1186/s12974-020-01945-8
  21. Chakraborty, Anirban; Tapryal, Nisha; Venkova, Tatiana; Mitra, Joy; Vasquez, Velmarini; Sarker, Altaf H.; Duarte-Silva, Sara; et al. "Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis". Proceedings of the National Academy of Sciences 117 14 (2020): 8154-8165. http://dx.doi.org/10.1073/pnas.1917280117.
    10.1073/pnas.1917280117
  22. Guerra-Gomes, Sónia; Cunha-Garcia, Daniela; Marques Nascimento, Diana Sofia; Duarte-Silva, Sara; Loureiro-Campos, Eduardo; Morais Sardinha, Vanessa; Viana, João Filipe; et al. "IP 3 R2 null mice display a normal acquisition of somatic and neurological development milestones". European Journal of Neuroscience (2020): http://dx.doi.org/10.1111/ejn.14724.
    Accepted • 10.1111/ejn.14724
  23. Mendes, MO; Rosa, AI; Neves Carvalho, A; Nunes, MJ; Dionísio, Pedro; Rodrigues, E; Costa, Daniela; et al. "Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy". Molecular and Cellular Neuroscience (IF=3.312, Q2) (2019): http://dx.doi.org/10.1016/j.mcn.2019.01.003.
    Published • 10.1016/j.mcn.2019.01.003
  24. de Campos, A. B. S.; Duarte-Silva, S.; Neves-Carvalho, A.; Nogueira-Goncalves, G.; Silva-Fernandes, A.; Teixeira-Castro, A.; Brites, D.; Ambrosio, A. F.; Maciel, P.. "Autologous transplantation of intestine-isolated glia cells improves neuropathology and restores cognitive deficits in beta amyloid-induced neurodegeneration". Glia (2019): https://publons.com/wos-op/publon/48978951/.
  25. Silva, J. D.; Duarte-Silva, S.; Neves-Carvalho, A.; Soares-Cunha, C.; Correia, J.; Nogueira-Goncalves, G.; Oliveira, S.; Teixeira-Castro, A.; Maciel, P.. "A glucocorticoid receptor-dependent mechanism of bile acid action with therapeutic impact in polyglutamine disease". Journal of Neurochemistry (2019): https://publons.com/wos-op/publon/30410181/.
  26. Esteves S; Oliveira S; DUARTE-SILVA, S; Cunha-Garcia D; Teixeira-Castro A; Maciel P. "Preclinical Evidence Supporting Early Initiation of Citalopram Treatment in Machado-Joseph Disease.". Molecular neurobiology (IF= 5.076; Q1) (2018): http://europepmc.org/abstract/med/30173407.
    Published • 10.1007/s12035-018-1332-1
  27. Ashraf NS; DUARTE-SILVA, S; Shaw ED; Maciel P; Paulson HL; Teixeira-Castro A; Costa MDC. "Citalopram Reduces Aggregation of ATXN3 in a YAC Transgenic Mouse Model of Machado-Joseph Disease.". Molecular neurobiology (IF= 5.076; Q1) (2018): http://europepmc.org/abstract/med/30187384.
    Published • 10.1007/s12035-018-1331-2
  28. DUARTE-SILVA, S; Rosa AI; Silva-Fernandes A; Nunes MJ; Carvalho AN; Rodrigues E; Gama MJ; et al. "Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease.". Molecular neurobiology (IF= 5.076; Q1) (2018): http://europepmc.org/abstract/med/29651747.
    Published • 10.1007/s12035-018-1062-4
  29. DUARTE-SILVA, S; Neves-Carvalho A; Soares-Cunha C; Silva JM; Teixeira-Castro A; Vieira R; Silva-Fernandes A; Maciel P. "Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3.". Movement disorders : official journal of the Movement Disorder Society (IF=8.3; Q1) (2018): http://europepmc.org/abstract/med/29570846.
    Published • 10.1002/mds.27292
  30. Esteves, S.; DUARTE-SILVA, S; Maciel, P.. "Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts". Medicinal Research Reviews (IF=9.135; Q1) 37 4 (2017): 860-906. http://www.scopus.com/inward/record.url?eid=2-s2.0-85005814142&partnerID=MN8TOARS.
    Published • 10.1002/med.21425
  31. Lopes S; Lopes A; Pinto V; Guimarães MR; Sardinha VM; DUARTE-SILVA, S; Pinheiro S; et al. "Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment.". Aging Cell (IF=5.76; Q1) (2016): http://europepmc.org/abstract/med/26748966.
    Published • 10.1111/acel.12391
  32. DUARTE-SILVA, S; Silva-Fernandes A; Neves-Carvalho A; Soares-Cunha C; Teixeira-Castro A; Maciel P. "Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.". Neuroscience (IF=3.231; Q1) (2016): http://europepmc.org/abstract/med/26601773.
    Published • 10.1016/j.neuroscience.2015.11.030
  33. Ramos A; Kazachkova N; Silva F; Maciel P; Silva-Fernandes A; DUARTE-SILVA, S; Santos C; Lima M. "Differential mtDNA damage patterns in a transgenic mouse model of Machado-Joseph disease (MJD/SCA3).". Journal of Molecular Neuroscience (IF=2.352; Q3) (2015): http://europepmc.org/abstract/med/25001003.
    Published • 10.1007/s12031-014-0360-1
  34. Neves-Carvalho A; Logarinho E; Freitas A; DUARTE-SILVA, S; Costa Mdo C; Silva-Fernandes A; Martins M; et al. "Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.". Human Molecular Genetics (IF=6.393; Q1) (2015): http://europepmc.org/abstract/med/25143392.
    Published • 10.1093/hmg/ddu422
  35. Teixeira-Castro, A.; Jalles, A.; Esteves, S.; Kang, S.; Da Silva Santos, L.; Silva-Fernandes, A.; Neto, M.F.; et al. "Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease". Brain (IF=10.103; Q1) 138 11 (2015): 3221-3237. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947806720&partnerID=MN8TOARS.
    Published • 10.1093/brain/awv262
  36. Esteves S; DUARTE-SILVA, S; Naia L; Neves-Carvalho A; Teixeira-Castro A; Rego AC; Silva-Fernandes A; Maciel P. "Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.". PLoS ONE (IF=3.234; Q1) (2015): http://europepmc.org/abstract/med/26505994.
    Published • 10.1371/journal.pone.0141610
  37. DUARTE-SILVA, S; Neves-Carvalho A; Soares-Cunha C; Teixeira-Castro A; Oliveira P; Silva-Fernandes A; Maciel P. "Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease.". The Cerebellum (IF=2.717; Q1) (2014): http://europepmc.org/abstract/med/25112410.
    Published • 10.1007/s12311-014-0589-9
  38. Sotiropoulos I; Lopes AT; Pinto V; Lopes S; Carlos S; DUARTE-SILVA, S; Neves-Carvalho A; et al. "Selective impact of Tau loss on nociceptive primary afferents and pain sensation.". Experimental Neurology (IF=4.657; Q1) (2014): http://europepmc.org/abstract/med/25079367.
    Published • 10.1016/j.expneurol.2014.07.008
  39. DUARTE-SILVA, S; Silva-Fernandes A; Neves-Carvalho A; Amorim M; Soares-Cunha C; Oliveira P; Thirstrup K; Teixeira-Castro A; Maciel P. "Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease.". Neurotherapeutics (IF=5.054; Q1) (2014): http://europepmc.org/abstract/med/24477711.
    Published • 10.1007/s13311-013-0255-9
  40. Kazachkova N; Raposo M; Montiel R; Cymbron T; Bettencourt C; Silva-Fernandes A; DUARTE-SILVA, S; Maciel P; Lima M. "Patterns of mitochondrial DNA damage in blood and brain tissues of a transgenic mouse model of Machado-Joseph disease.". Neurodegenerative Diseases (IF=3.454; Q1) (2013): http://europepmc.org/abstract/med/22832131.
    Published • 10.1159/000339207
  41. DUARTE-SILVA, S; Silva-Fernandes A; Costa Mdo C; Oliveira P; Botelho CM; Martins L; Mariz JA; et al. "Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products.". Neurobiology of Disease (IF=5.121; Q1) (2010): http://europepmc.org/abstract/med/20510362.
    Published • 10.1016/j.nbd.2010.05.021
  42. Santos M; Summavielle T; Teixeira-Castro A; Silva-Fernandes A; DUARTE-SILVA, S; Marques F; Martins L; et al. "Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome.". Neuroscience (IF=3.215; Q1) (2010): http://europepmc.org/abstract/med/20633611.
    Published • 10.1016/j.neuroscience.2010.07.010
  43. Silva-Fernandes, Anabela; Costa, Maria Do Carmo; Duarte-Silva, Sara; Costa, Cristina; Oliveira, Pedro; Maciel, Patricia. "Genotype-Phenotype Correlation in a Transgenic Mouse Model of Machado-Joseph Disease". Neurology (2009): https://publons.com/wos-op/publon/7571444/.
  44. Cruto, Teresa; Teixeira-Castro, Andreia; Silva-Fernandes, Anabela; Costa, Maria do Carmo; Duarte-Silva, Sara; Maciel, Patricia. "Region-Specific Changes in the Expression of Hsp70 in the Central Nervous System of a Transgenic Mouse Model of Machado-Joseph Disease". Neurology (2009): https://publons.com/wos-op/publon/30410186/.
Preprint
  1. Alexandra Silva; Sara Duarte-Silva; Pedro M. Martins; Beatriz Rodrigues; Débora Serrenho; Daniela Vilasboas-Campos; Andreia Teixeira-Castro; et al. "Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies". 2025. https://doi.org/10.1101/2025.01.22.633970.
    10.1101/2025.01.22.633970
Thesis / Dissertation
  1. Maciel, P.; Silva, Sara Carina Duarte. "Searching for therapeutic strategies in a mouse modelo of Machado-Joseph disease: targeting proteostases". PhD, 2015. http://hdl.handle.net/1822/40642.
  2. Maciel, P.; Fernandes, Anabela Silva; Schuller, Dorit Elisabeth; Silva, Sara Carina Duarte. "Insights into pathology and neurodegeneration features in a transgenic mouse model of Machado-Joseph disease". Master, 2011. http://hdl.handle.net/1822/18994.

Other

Other output
  1. MorphData: Automating the data extraction process of morphological features of microglial cells in ImageJ. 2021. Campos, A.B.; Duarte-Silva, S.; Ambrósio, A.F.; Maciel, P.; Fernandes, B.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115303617&partnerID=MN8TOARS.
    10.1101/2021.08.05.455282
  2. Assessment of the Gastrointestinal Fate of Bacterial Cellulose and Its Toxicological Effects After Repeated-dose Oral Administration. 2021. Gama, M.; Rodrigues, A.C.; Rodrigues, L.; Duarte-Silva, S.; Teixeira-Castro, A.; Lamas, N.; Dourado, F.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85132134278&partnerID=MN8TOARS.
    10.21203/rs.3.rs-1117993
  3. Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors. 2019. Neves-Carvalho, A.; Duarte-Silva, S.; Silva, J.; Almeida, B.; Heetveld, S.; Sotiropoulos, I.; Heutink, P.; Li, K.W.; Maciel, P.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095638735&partnerID=MN8TOARS.
    10.1101/711424
  4. Pre-Clinical Assessment of Mesenchymal Stem Cell-Based Therapies in Spinocerebellar Ataxia Type 3. 2019. Neves-Carvalho, A.; Mendes-Pinheiro, B.; Correia, J.S.; Pires, J.; Teixeira, F.G.; Silva, N.; Lima, R.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85109511656&partnerID=MN8TOARS.
    10.2139/ssrn.3475576
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07/04 Glucocorticoid receptor-dependent therapeutic efficacy of TUDCA in preclinical models of Machado-Joseph disease ICVS summer retreat
ICVS (Braga, Portugal)
2024/05/29 The nematode C. elegans in the study of neurodegenerative diseases: the bridge to mouse studies III Workshop in Mouse Models
University of Évora (Évora, Portugal)
2024/01/25 Enhancing animal welfare and research accuracy with DVC®: A study on non-intrusive monitoring of rodent behavior and activity V CONGRESSO DA SPCAL
SPCAL (Coimbra, Portugal)
2022/11/03 CLR01, a molecular tweezer, attenuates motor dysfunction and pathology in SCA3 in vivo models International Congress for Ataxia Research
The National Ataxia Foundation (NAF), the Friedreich’s Ataxia Research Alliance (FARA), and Ataxia UK (Dallas, Texas, United States)
2022/11/02 The Glucocorticoid Receptor as a Biomarker and Neuronal Therapeutic Target of a Disease-Improving Bile Acid in SCA3/MJD International Congress for Ataxia Research (ICAR) 2022
NAF (Texas, United States)
2022/06/13 Digital Ventilated Cages (DVC) as a tool for the study of Machado-Joseph Disease: Influence of physical exercise on established motor dysfunction in transgenic MJD mice 15th FELASA congress
FELASA and AFSTAL (Marseille)
2019/11/14 Disease-modifying therapies for SCA3: lessons from preclinical trials International Ataxia Research Conference (IARC)
Ataxia UK (Washington, United States)
2018/04/03 Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease. Portuguese Society of Movement Disorders.
Portuguese Society of Movement Disorders. (Curia, Portugal)
2018/03/03 Testing peripheral BDNF gene delivery using neuron-targeted nanoparticles as a strategy to reduce skeletal muscle atrophy and motor neuronopathy in a mouse model of SCA3 Portuguese Society of Movement Disorders.
Portuguese Society of Movement Disorders. (Curia, Portugal)
2017/05/10 Neuroprotective effects of creatine-supplemented diet in the CMVMJD135 mouse model of Machado-Joseph disease. Jornadas de Química e Bioquímica
University of Beira Interior (Covilhã, Portugal)
2017/04/23 Neuroprotective effects of creatine-supplemented diet in the CMVMJD135 mouse model of Machado-Joseph disease. Portuguese Society of Movement Disorders
Portuguese Society of Movement Disorders (Póvoa de Varzim)
2016/03/30 TUDCA reduces neuroinflammation and improves motor symptoms in a transgenic mouse model of Machado-Joseph disease. 6th Ataxia Investigators Meeting
National Ataxia Foundation (Orlando, United States)
2015/04/14 Tauroursodeoxycholic acid reduces neuroinflammation and improves motor symptoms in a transgenic mouse model of Machado-Joseph disease Portuguese Society of Movement disorders
Portuguese Society of Movement disorders (Póvoa de Varzim, Portugal)
2013/11/23 Creatine food supplementation improves the motor phenotype of a transgenic mouse model of Machado-Joseph disease 17th meeting of the Portuguese Society of Human Genetics
Human Genetics Society (Coimbra, Portugal)
2012/11/02 17-DMAG and Valproic acid improve the phenotype of a new transgenic mouse model of Machado-Joseph disease Ataxia Research Conference
Ataxia UK (London, United Kingdom)
2010/05/06 No evidence for apoptosis or necrosis in spite of neurodegeneration in a transgenic mouse model of MJD/SCA3 EMBO Workshop: Proteolysis and Neurodegeneration
EMBO (Madrid, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/02/01 - Current Testing the therapeutic efficacy of magnetic lipid nanoparticles in neuroinflammation: advances for Parkinson’s and Machado-Joseph diseases
Supervisor
 Biomedicine and Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022/09/01 - Current Estudo da via de sinalização do Glucocorticoid-Krüppel-like Factor 15 na Ataxia Espinocerebelosa ar do tipo 3: O impacto no músculo esquelético no modelo de ratinho CMVMJD135
Supervisor
 Master in Medicine (Master)
Universidade do Minho, Portugal
2021/10/01 - Current The skeletal muscle in SCA3: contribution to disease, potential for biomarker development and therapeutic target
Supervisor
 Health Sciences (PhD)
Universidade do Minho, Portugal
2021/04/02 - Current Cell and gene-based approaches to target identification and therapy development in SCA3/MJD
Co-supervisor
 PhD (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/11/02 - Current Integration of behavior and cerebellar-neuronal physiology in a mouse model of Rett Syndrome: a particular focus on serotonergic system modulation
Co-supervisor
 Health Sciences (PhD)
Universidade do Minho, Portugal
2018/09/15 - Current Cell and gene-based approaches for target identification and therapy development in SCA3/MJD
Supervisor
 Health Sciences (PhD)
Universidade do Minho, Portugal
2022/09/01 - 2024/01/16 Interneuron differentiation and development in Rett Syndrome
Supervisor
 Master in Health Sciences (Master)
Universidade do Minho, Portugal
2021/09/01 - 2023/12/09 THE CHOROID PLEXUS ROLE IN CSF PRODUCTION AND BRAIN HOMEOSTASIS: FUNCTION REVISITING
Supervisor
 Master in Health Sciences (Master)
Universidade do Minho, Portugal
2022/06/01 - 2022/11/07 Stereotypies in MECP2-mutant female mouse model of Rett Syndrome: characterisation and response to treatment with a 5-HT1A receptor agonist
Supervisor
 Master in Medicine (Master)
Universidade do Minho, Portugal
2020/03/01 - 2022/04/22 Study the therapeutic efficacy of MAPT (Tau-4R) protein overexpression in the onset and progression of Machado-Joseph disease
Supervisor
 Health Sciences (Master)
Universidade do Minho, Portugal
2021/08/01 - 2021/09/04 In vivo evaluation of chromene-derivative toxicity
Supervisor
 Medicine Lab rotation (Other)
Universidade do Minho, Portugal
2019/09/01 - 2021/03/29 Digital Ventilated Cages (DVC®) as tool for the study of Machado-Joseph Disease: Influence of physical exercise on established motor dysfunction in a transgenic mouse model of MJD
Co-supervisor
 Biotechnology (Master)
Universidade da Beira Interior, Portugal
2018/09/01 - 2021/03/18 Impact of astrocytic calcium suppression in the pathogenesis of Machado-Joseph disease
Supervisor of Daniela Cunha Garcia
 Master in Health Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/06/01 - 2016/05/15 Assessment of neuroprotection ant anti-inflammatory effects of TUDCA in the CMVMJD135 mouse model of Machado-Joseph disease
Co-supervisor
 BSc (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2015/06/14 - 2016/01/04 Neuroinflammation in a mouse model of Machado-Joseph disease: TUDCA as an inflammatory modulator and neuroprotective agent
Co-supervisor
 Integrated Masters in medicine (Master)
Universidade do Minho Escola de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/12/12 - 2020/12/12 Annual Neuroscience Research Domain Scientific Retreat (2020/12/12 - 2021/12/12)
Meeting (Member of the Organising Committee)
 Universidade do Minho, Portugal
2018/08/28 - 2019/08/31 International Meeting: EBPS BIENNIAL MEETING 2019 (2019/08/28 - 2019/08/31)
Meeting (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2018/10/01 - 2018/12/02 Annual Neuroscience Research Domain Scientific Retreat (2018/11/30 - 2018/12/01)
Meeting (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2017/04 - 2017/05 XV Meeting of the Portuguese Society for Neurosciences (2017/05/25 - 2017/05/26)
Meeting (Other)
 Universidade do Minho Escola de Medicina, Portugal
2005 - 2005 Applied Biology Meeting (2005/11 - 2005/11)
Meeting (Member of the Organising Committee)
 Universidade do Minho Escola de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/02/21 - Current Rare Disease Day
Other
 Rare Disease Day awareness
Universidade do Minho, Portugal
2024/09/12 - 2024/09/13 How to prepare a scientific poster
Meeting
 IX Edição do Meeting Medical Education
Universidade do Minho, Portugal
2018/06 - 2018/06 Poster presentation
Workshop
 Workshop on Integrative Approaches in Neurodegeneration
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/03 - 2018/03 Oral communication
Conference
 Portuguese Society of Movement Disorders
2018 - 2018 Workshop attendee
Workshop
 I Workshop on the cerebellum: motor and non-motor functions
Universidade do Minho Escola de Medicina, Portugal
2017/05/25 - 2017/05/26 Poster presentation
Congress
 XV Meeting of the Portuguese Society for Neurosciences
Universidade do Minho, Portugal
2017/04 - 2017/04 Course attendee
Congress
 Advanced course: Pathogenesis in neurodegenerative diseases
Universidade do Minho Escola de Medicina, Portugal
2017/03 - 2017/03 Oral communication
Conference
 Portuguese Society of Movement Disorders
2016/03/29 - 2016/04/01 Oral communication
Meeting
 6th Ataxia Investigators Meeting (AIM 2016)
National Ataxia Foundation, United States
2015/06/04 - 2015/06/05 Poster presentation
Conference
 XIV Meeting of the Portuguese Society for Neurosciences
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/03/13 - 2015/03/14 Oral communication
Congress
 Portuguese Society of Movement Disorders
2013/06/04 - 2013/06/05 Poster presentation
Conference
 XXXVIII Portuguese Genetics Conference
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/05/30 - 2013/06/01 Poster presentation
Congress
 XIII Meeting of the Portuguese Society for Neurosciences
Universidade de Coimbra, Portugal
2012/11/01 - 2012/11/03 Oral communication
Conference
 Ataxia Research Conference
Ataxia UK, United Kingdom
2012 - 2012 Poster presentation
Congress
 Mouse Models of disease - linking in vivo observations to pathology endpoints
Wellcome Genome Campus, United Kingdom
2012 - 2012 Poster presentation
Meeting
 6th National Meeting on Cell Signaling (SINAL)
Universidade do Minho, Portugal
2011/05/26 - 2011/05/28 Poster presentation
Meeting
 XII Meeting of the Portuguese Neuroscience Society
Instituto de Medicina Molecular, Portugal
2011 - 2011 Workshop attendee
Workshop
 Novel experimental therapies for diseases of the nervous system
Harvard Medical School, United States
2011 - 2011 Workshop attendee
Workshop
 Animal models in Neurosciences
Harvard Medical School, United States
2010 - 2010 Poster presentation
Conference
 Neurodegenerative diseases: biology & therapeutics
Cold Spring Harbor Laboratory, United States
2009/04 - 2009/04 Poster presentation
Workshop
 V International Workshop on Machado-Joseph disease, Azores
Universidade dos Açores Departamento de Biologia, Portugal
2005/11/10 - 2005/11/12 Meeting attendee
Meeting
 VII Meeting of Applied Biology
Universidade do Minho Escola de Ciências, Portugal
2004/11/11 - 2004/11/12 Meeting attendee
Meeting
 VI Meeting of Applied Biology
Universidade do Minho Escola de Ciências, Portugal
2003/11/10 - 2003/11/12 Meeting organising committee
Meeting
 V Meeting of Applied Biology
Universidade do Minho Escola de Ciências, Portugal
2002/11/11 - 2002/11/12 Meeting attendee
Meeting
 IV Meeting of Applied Biology
Universidade do Minho Escola de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/11/18 The role of cytotoxic granule-associated RNA binding-protein TIA1 in stress-driven Tau pathology
(Thesis) Main arguer
 Luís Santos (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2024/06/18 Involvement of sensory inputs to the nucleus accumbens in cue-outcome associative learning
(Thesis) Arguer
 Anabela Campos Ferreira (Master)
Universidade do Minho, Portugal
2024/03/01 Combinatory use of Gellan Gum and Mesenchymal Stem Cells to Promote Traumatic Brain Injury Regeneration
(Thesis) Arguer
 Helena Cavaleiro (PhD)
Universidade do Minho, Portugal
2023/12/13 The therapeutical potential of TUDCA against stress related brain pathologies
(Thesis) Main arguer
 Rita Nóbrega (Master)
Universidade do Minho Departamento de Biologia, Portugal
2023/12/12 Tau protein as a regulator of the hippocampal neurogenic niche
(Thesis) Arguer
 Iara Pereira (Master)
Universidade do Minho Escola de Medicina, Portugal
2017/01/03 Master in Medicine
(Thesis) Arguer
 Micaela José Nunes Sousa (Master)
Universidade do Minho Escola de Medicina, Portugal
2016/01/04 Master in Medicine
(Thesis) Arguer
 Rui Pedro Bragança Rebelo (Master)
Universidade do Minho Escola de Medicina, Portugal

Committee member

Activity description
Role 		Institution / Organization
2023/01/05 - Current Grant proposal reviewer
Advisor / Consultant
2018/01/20 - Current Member of the AWB (Animal Welfare Body) of ICVS/I3B’s.
Member
 Universidade do Minho Escola de Medicina, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015/09/10 - Current Fundamentals in Neurosciences (FiNs) at ICVS, School of Medicine, University of Minho; theoretical class on motor behavior (Annual Editions 2015-2022). Co-coordination of the FiNs advanced course (2024-2027). (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Minho Escola de Medicina, Portugal
2012/09/05 - Current Laboratory Animal Science advanced course at ICVS, School of Medicine, University of Minho– practical classes (Annual Editions) (Outros) Universidade do Minho Escola de Medicina, Portugal
2025/01/10 - 2025/01/17 Data management Peer-review process Master in Biomedicine (Pós-Graduação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2019/02/08 - Current Laboratory Animal Science course Universidade do Minho Escola de Medicina, Portugal

Interview (tv / radio show)

Program Topic
2021/02/25 - Current Café com Ciência
2018/04/21 - 2018/04/21 Daily Portuguese News (RTP1) Press release: Creatine treatment for Machado-Joseph disease

Mentoring / Tutoring

Topic Student name
2018/12/01 - Current The role of glial cells in the pathogenesis of Machado-Joseph disease Daniela Monteiro Fernandes
2018/01/04 - Current TUDCA as a therapeutic strategy for Machado-Joseph disease Jorge Diogo da Silva
2018/01/04 - Current Ataxin-3 in Health and Disease Bruna Lomba
2017/08/01 - Current Testing the therapeutic potential of mesenchymal stem cells and their secretome in an animal model of spinocerebellar ataxia type 3 Joana Sofia Correia
2012/05/02 - Current Laboratory Rotations on ongoing research projects Medical students
2013/09/01 - 2014/09/02 Master in Health Sciences Revina Ann Mary Marslin
2012/09/01 - 2013/09/02 Master in Molecular Genetics Ana Marina Amorim
Distinctions

Award

2019 Best 5 posters award
European Behavioral Pharmacology Society, Germany
2016 National Ataxia Foundation (NAF) award for the AIM meeting at Orlando, USA
National Ataxia Foundation, United States
2013 Prize Prof. Doutor Luís Archer - Best poster presentation at ICBAS, University of Porto, PT
2009 Best poster at V International meeting on Machado-Joseph disease, Azores, PT