Carla Isabel Soares Guedes (2B11-8C00-A60D)

Curriculum Vitae

Carla Isabel Soares Guedes

Carla Guedes (CG), is graduated in Biomedical Laboratory Sciences from the School of Health of the Polytechnic Institute of Bragança and a Master's in Clinical Analyses and Public Health - Microbiology and Public Health from the School of Health of the Polytechnic Institute of Porto. After such period, CG was a scholarship researcher at Porto Research, Technology and Innovation Center (PORTIC) - Porto Polytechnic Institute, having participated in several projects in different research areas, with activities in virology, molecular biology, microbiology, and cell culture analyses and procedures. Currently, CG is the Lab Manager at the Research Center for Translational Health and Medical Biotechnology (TBIO) of the School of Health of Porto Polytechnic Institute. At the end of 2022, given their interest in inflammation and neurosciences, CG was integrated into a research team in "Experimental Neurodegeneration Biology", aiming to explore the role of neuroinflammation in the initiation and progression of Parkinson's disease and how the gut-brain axis may be a player on such process/mechanism.

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Identification

Personal identification

Full name: Carla Isabel Soares Guedes

Citation names

Soares-Guedes, Carla
Guedes, Carla

Author identifiers

Ciência ID: 2B11-8C00-A60D
ORCID iD: 0000-0002-3277-7821
AuthenticusID: R-00K-FY0
Researcher Id: D-3704-2017
Scopus Author Id: 57447314300

Email addresses

cisg@ess.ipp.pt (Professional)
cguedes@i3s.up.pt (Professional)

Addresses

Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)
R. Dr. António Bernardino de Almeida 400, 4200-072, Porto, Porto, Portugal (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology
Natural sciences - Biological Sciences - Microbiology

Education

	Degree	Classification
2024/01/01 - 2027/12/31 Ongoing	FCT Grant PhD (Doutoramento) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09/11 - 2027/07/31 Ongoing	Neuroscience Doctoral Programme (PhD) (Doutoramento) Major in Neurociências Experimentais Faculdade de Medicina da Universidade do Porto, Portugal
2019/10/07 - 2021/12/10 Concluded	Master Degree in Clinical Analysis and Public Health - Microbiology and Public Health (Mestrado) Major in Microbiologia e Saúde Pública Instituto Politécnico do Porto Escola Superior de Saúde, Portugal "Bioterapia da infeção por SARS-CoV-2 com nanobodies geneticamente modificados" (THESIS/DISSERTATION)	17 Valores
2021/04/09 - 2021/04/09 Concluded	Covid-19: Harvesting techniques, detection methods and protection measures (Technological specialisation course) (Curso de Especialização Tecnológica) Major in Técnicas de colheita, métodos de deteção e medidas de proteção Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal Cruz Vermelha Portuguesa, Portugal
2015/09/14 - 2019/07/12 Concluded	Biomedical Laboratory Sciences (BSc) (Licenciatura) Major in Análises Clínicas e Saúde Pública - Anatomia Patológica, Citológica e Tanatológica Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal	14 Valores
2018/05/18 - 2018/05/19 Concluded	Animal Cell Culture and Clinical Applications Course (Outros) Major in Cell Cultures Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal
2014/09/15 - 2015/07/17 Concluded	Technological Specialisation in Laboratory Technician (Curso de Especialização Tecnológica) Major in Técnica de Laboratório Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal	15 Valores

Affiliation

Science

	Category Host institution	Employer
2022/02/01 - 2023/12/31	Researcher (Research)	Instituto Politécnico do Porto, Portugal
	Centro de Investigação em Saúde Translacional e Biotecnologia Médica, Portugal
2020/08/10 - 2022/01/31	Researcher (Research)	Instituto Politécnico do Porto, Portugal
	Laboratório de Biotecnologia Médica e Industrial, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2023/02/13 - 2023/06/30	Invited Assistant Professor (University Teacher)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
	Instituto Politécnico do Porto, Portugal

Positions / Appointments

	Category Host institution	Employer
2020/06/25 - 2020/07/17	Diagnostic and Therapeutic Technicians	Instituto Politécnico do Porto, Portugal
	Porto Research, Technology & Innovation Center, Portugal

Others

	Category Host institution	Employer
2019/06/24 - 2019/07/12	Intern	Instituto Nacional de Medicina Legal e Ciências Forenses, Portugal

2018/09/18 - 2019/06/21	Intern	Centro Hospitalar Universitário do Porto EPE, Portugal

2019/04/23 - 2019/05/10	Intern	Centro de Saúde de Braga, Portugal

2015/05 - 2015/07	Intern	Centro de Investigação de Montanha, Portugal
	Instituto Politécnico de Bragança Escola Superior Agrária, Portugal

Projects

Grant

	Designation	Funders
2024/01/01 - 2027/12/31	PD-FOCUS - Transient Blood-Brain Barrier permeabilization by Magnetic Resonance Imaging-guided Focused Ultrasound: can we create a path for an early Parkinson's Disease modulation? 2023.03466.BD Research Fellow	Fundação para a Ciência e a Tecnologia Ongoing

Contract

	Designation	Funders
2023/03/12 - 2024/09/11	Use of Aptarmers towards Theranostics and Precision Medicine in Prostate Carcinoma 2022.09032.PTDC Fundação Ensino e Cultura Fernando Pessoa, Portugal Instituto Politécnico do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021/02/01 - 2023/05/14	Prevention and Sustainable Optimization of the Diagnosis of COVID-19 on a Large Scale (IPP4COVID) RESEARCH4COVID Research Fellow Instituto Politécnico do Porto, Portugal Porto Research, Technology & Innovation Center, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021/02/01 - 2022/02/28	SARS-CoV-2 Molecular Diagnosis: Feira / Arouca IPP4AFA Research Fellow Instituto Politécnico do Porto, Portugal Porto Research, Technology & Innovation Center, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021/02/01 - 2022/02/28	SARS-CoV-2 Molecular Diagnosis: Vale do Sousa Sul IPP4AVSS Research Fellow Instituto Politécnico do Porto, Portugal Porto Research, Technology & Innovation Center, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021/02/01 - 2022/02/28	Hyperinflammation and immunological profile of patients with COVID-19 Vila Gaia / Espinho iHIPI Research Fellow Porto Research, Technology & Innovation Center, Portugal Instituto Politécnico do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020/08/10 - 2021/08/04	European Effectiveness Study I-MOVE-COVID-19 Research Fellow Porto Research, Technology & Innovation Center, Portugal Instituto Nacional de Saúde Doutor Ricardo Jorge Porto, Portugal	Concluded

Outputs

Publications

Conference poster	Cristiana Vilela; Rita Caridade Silva; Bruna Alexandra Vale Araújo; Catarina Correia Teixeira; Joana Catarina Martins Macedo; Guedes, Carla; Eduardo Gomes; et al. Corresponding author: Cristiana Vilela. "Modulating Microbiome with N-acetylcysteine: Unveiling New Therapeutic Paths for Parkinson´s Disease". Paper presented in Annual Meeting 2024 I TBIO, 2024. Soares-Guedes, Carla; Caridade-Silva, Rita; Bruna Alexandra Vale Araújo; Catarina Correia Teixeira; Joana Catarina Martins Macedo; Vilela, Cristiana; Eduardo Gomes; et al. "PD-FOCUS - Transient Blood-Brain Barrier permeabilization by Magnetic Resonance Imaging-guided Focused Ultrasound: can we create a path for an early Parkinson’s Disease modulation?". Paper presented in Annual Meeting 2024 I TBIO, 2024. Bruna Alexandra Vale Araújo; Rita Caridade Silva; Vilaça- Ferreira, AC.; Joana Catarina Martins Macedo; Catarina Correia Teixeira; Soares-Guedes, Carla; Eduardo Gomes; et al. Corresponding author: Bruna Alexandra Vale Araújo. "Impact of Hippocampal Cytogenesis Abrogation in the neurodegeneration process of Parkinson's Disease". Paper presented in Annual Meeting 2024 I TBIO, 2024. Rita Caridade Silva; Bruna Alexandra Vale Araújo; Vilaça- Ferreira, AC.; Vilela, Cristiana; Catarina Correia Teixeira; Joana Catarina Martins Macedo; Soares-Guedes, Carla; et al. Corresponding author: Rita Caridade Silva. "Neurorescue Effects of N-Acetylcysteine Monotherapy on Neural Circuit Modulation: Insiights From a 6-OHDA Intrastriatal Animal Model of Parkinson´s Disease". Paper presented in Annual Meeting 2024 I TBIO, 2024. Vilela, Cristiana; Caridade-Silva, Rita; Araújo, Bruna; Soares-Guedes, Carla; Teixeira, Catarina; Gomes, Eduardo D.; Vieira, Mónica; Teixeira, Fábio G. Corresponding author: Teixeira, Fábio G. "N-acetylcysteine as a modulator of Microbiome levels: A New Aproach For Parkinson’s Disease Treatment?". Paper presented in Encontro Ciência 2024 - Encontro com a Ciência e a Tecnologia, 2024. Aveiro, Alexandra; Soares-Guedes, Carla; André P Sousa; Teixeira, Catarina; Baylina Machado, Pilar; Pereira, Ana. "The influence of secretome adipocytes on bacterial infections and immune response". Paper presented in 1st Conference of the Doctoral Program in Metabolism Clinical and Experimental, 2022. 0D1F-4090-E82A. Corresponding author: 0D1F-4090-E82A. "The synergic effect of antibiotics and biofilm formation is dependent of oxidative stress genes in P. aeruginosa". Paper presented in XXVIII Congresso Sociedad Española de Microbiología, 2021. 0000-0001-5817-6226. Corresponding author: 0000-0001-5817-6226. "Phylogenetic Insights of ß-lactam resistance: focus on CTX-M family". Paper presented in XXVIII Congresso Sociedad Española de Microbiología, 2021. 0D1F-4090-E82A. Corresponding author: 0D1F-4090-E82A. "Oxidative stress genes involved in the virulencedependent susceptibility to antibiotics in P. aeruginosa". Paper presented in XXVIII Congresso Sociedad Española de Microbiología, 2021. 471F-9426-6FFD. Corresponding author: 471F-9426-6FFD. "Avaliação do Potencial Anti-Tumoral da Fármacos Antidiabéticos em Cancro de Próstata". Paper presented in 17º Congresso da Sociedade Portuguesa de Diabetologia, 2021. 471F-9426-6FFD. Corresponding author: 471F-9426-6FFD. "Efeito da Testosterona e Estradiol no Paradoxo Diabetes/Cancro de Próstata". Paper presented in 17º Congresso da Sociedade Portuguesa de Diabetologia, 2021. F414-DA83-F977. Corresponding author: F414-DA83-F977. "Alterações Morfopatológicas no Rim de Rato com Obesidade e Insulino-Resistência". Paper presented in 17º Congresso da Sociedade Portuguesa de Diabetologia, 2021. Soares-Guedes, Carla. "Estilos de vida na Europa do Sul: Portugal". Paper presented in I Congresso Nacional de Ciências Biomédicas Laboratoriais, 2016.
Journal article	Vilela, Cristiana; Araújo, Bruna; Soares-Guedes, Carla; Caridade-Silva, Rita; Martins-Macedo, Joana; Teixeira, Catarina; Gomes, Eduardo D.; et al. "From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment?". Cells 13 9 (2024): 770. http://dx.doi.org/10.3390/cells13090770. 10.3390/cells13090770 Vilela, Cristiana; Araújo, Bruna; Soares-Guedes, Carla; Caridade-Silva, Rita; Martins-Macedo, J; Teixeira, Catarina; Gomes, Eduardo D.; et al. Corresponding author: Teixeira, Fábio G. "From the Gut to the Brain: Is microbiome a new paradigm in Parkinson’s Disease Treatment?". Cells (2024): Accepted Luís, Carla; Guerra-Carvalho, Bárbara; Braga, Patrícia C.; Guedes, Carla; Patrício, Emília; Alves, Marco G.; Fernandes, Ruben; Soares, Raquel. "The Influence of Adipocyte Secretome on Selected Metabolic Fingerprints of Breast Cancer Cell Lines Representing the Four Major Breast Cancer Subtypes". Cells 12 17 (2023): 2123. http://dx.doi.org/10.3390/cells12172123. 10.3390/cells12172123 Ana Fernandes; Ana Oliveira; Carla Guedes; Rúben Fernandes; Raquel Soares; Pedro Barata. "Effect of Radium-223 on the Gut Microbiota of Prostate Cancer Patients: A Pilot Case Series Study". Current Issues in Molecular Biology (2022): https://doi.org/10.3390/cimb44100336. 10.3390/cimb44100336 Bruna Araújo; Rita Caridade-Silva; Carla Soares-Guedes; Joana Martins-Macedo; Eduardo D. Gomes; Susana Monteiro; Fábio G. Teixeira. "Neuroinflammation and Parkinson's Disease: From Neurodegeneration to Therapeutic Opportunities". Cells (2022): https://doi.org/10.3390/cells11182908. 10.3390/cells11182908 Ana Fernandes; Ana Oliveira; Carla Guedes; Rúben Fernandes; Raquel Soares; Pedro Barata. "Ionizing Radiation from Radiopharmaceuticals and the Human Gut Microbiota: An Ex Vivo Approach". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231810809. 10.3390/ijms231810809 Jacinta Mendonça; Carla Guedes; Carina Silva; Sara Sá; Marco Oliveira; Gustavo Accioly; Pilar Baylina; et al. "New CTX-M Group Conferring ß-Lactam Resistance: A Compendium of Phylogenetic Insights from Biochemical, Molecular, and Structural Biology". Biology 11 2 (2022): 256-256. https://doi.org/10.3390/biology11020256. 10.3390/biology11020256 Fernandes, Ruben; Aveiro, Alexandra; Pereira, Claúdia; Silva, Carina; Guedes, Carla; Almeida, Cátia; Lima, Cláudio; et al. "Glutamate to Lysine is the most frequent missense mutation among extended spectrum cephalosporinases involved in the respiratory tract infections". Antibiotics (2022): Submitted Carina Silva; Sara Sá; Carla Guedes; Carla Oliveira; Cláudio Lima; Marco Oliveira; João Mendes; et al. "The History and Applications of Phage Therapy in Pseudomonas aeruginosa". Microbiology Research (2021): https://www.mdpi.com/2036-7481/13/1/2. 10.3390/microbiolres13010002
Thesis / Dissertation	"Bioterapia da infeção por SARS-CoV-2 com nanobodies geneticamente modificados". Master, Instituto Politécnico do Porto Escola Superior de Saúde, 2021. http://hdl.handle.net/10400.22/19848.

Activities

Event participation

	Activity description Type of event	Event name Institution / Organization
2021/04/12 - 2021/11/30	Health crisis solutions - Project "AGRO4COVID". Call	Angelini University Award! 2020/2021 Angelini University Award, Portugal
2021/01/29 - 2021/01/31	Portuguese Congress of Endocrinology 2021 Congress	Congresso Português de Endocrinologia 2021 - 72ª Reunião Anual da SPEDM Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal
2018/10/24 - 2018/10/31	Living with Severe Mental Illness - Project "Dandelion - Smile, Breath and go Slow" Call	Angelini University Award! 2017/2018 Angelini University Award, Portugal
2018/10/18 - 2018/10/19	16th International Symposium on Trombosis and Hemostasis, and 8th Meeting of the North Haematology Forum Congress	International Symposium on Thrombosis & Haemostasis
2017/10/18 - 2017/10/31	Development of Products and Services to combat Antibiotic Resistance - Project "B-PAM Conjugate in Combating Resistance to ESBLs". Call	Angelini University Award! 2016/2017 Morada Angelini Farmacêutica Lda, Portugal
2016/10/28 - 2016/10/30	I National Congress of Biomedical Laboratory Sciences Congress	I Congresso Nacional de Ciências Biomédicas Laboratoriais Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal
2015/04/23 - 2015/04/24	Participation in the 12-hour "Biofactories Bioproducts Innovation" workshop, conferring 1.5 ECTS. Workshop	Biofactories, Bioproducts and Innovation Instituto Politécnico de Bragança, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/06/27	Relatório de Estágio do Curso Técnico Superior Profissional em Laboratórios de Química e Bioquímica (Thesis) Arguer	Renata Beatriz da Costa Pinheiro (Other) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/06/27	Relatório de Estágio do Curso Técnico Superior Profissional em Laboratórios de Química e Bioquímica (Thesis) Arguer	Alexandra Gonçalves Ferreira (Other) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2023/02/15 - 2023/07/31	Técnicas Laboratoriais de Bioquímica (TLB1)	Biologia e Bioquímica (Curso Técnico Superior Profissional)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/02/15 - 2023/07/31	Análise Química de Alimentos e Bebidas (AQAB) - Ramo de Bioquímica Aplicada	Biologia e Bioquímica (Mestrado)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/02/15 - 2023/07/31	Análise Química de Alimentos e Bebidas (AQAB) - Ramo de Biotecnologia	Biologia e Bioquímica (Mestrado)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Distinctions

Other distinction

2023	Fundação para a Ciência e a Tecnologia Instituto Politécnico do Porto Escola Superior de Saúde, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal