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Monica M Sousa graduated in Biochemistry and holds a PhD in Biomedical Sciences from the University of Porto. During her PhD she studied the biology of an aggregation-prone protein that induces axon degeneration. As a postdoctoral fellow, Monica worked at Columbia University- New York, where she studied signaling cascades mediating neurodegeneration caused by amyloid fibrils. Since 2008, Monica leads the Nerve Regeneration group at the IBMC/i3S- University of Porto. Her group is focused on understanding cytoskeleton organization and dynamics during axon growth, degeneration and regeneration. Throughout the years, Monica has been the PI of grants from multiple national and international funding agencies, charities, accelerator programs and research sponsored agreements. Monica authored over 70 papers, including recent publications as a senior author in reference journals (Plos Biology 2022, Brain 2022, Developmental Cell 2022, Journal of Clinical Investigation 2020, eLife 2020). Beyond her publications, Monica participates regularly as an invitated speaker in leading conferences including EMBO and GRC meetings and International Societies. Monica has always been involved in the education of the next generation of (neuro)scientists by organizing post-graduate programs, and training students (10 concluded PhDs, 3 ongoing)and postdoctoral fellows (7 past, 3 ongoing) in her group. She is currently the director of the IBMC, one of the founder institutes of the i3S- University of Porto.
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Identification

Personal identification

Full name
Monica M Sousa

Citation names

  • Sousa, Monica M

Author identifiers

Ciência ID
2B16-E5A4-771C
ORCID iD
0000-0002-4524-2260

Email addresses

  • msousa@ibmc.up.pt (Professional)

Telephones

Telephone
  • 220408806 (Professional)

Addresses

  • Instituto de Investigação e Inovação em Saúde (i3S). Rua Alfredo Allen 208 , 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/05/11
Concluded
 Molecular and Cellular Biology- Neurobiology (Título de Agregado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1996/09/15 - 1999/12/20
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Cellular and molecular interactions of transthyretin in health and disease" (THESIS/DISSERTATION)
 Unanimidade
1994
Concluded
 Bioquimica (Licenciatura)
Universidade do Porto, Portugal
"Construction of expression vectors for CRBP" (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2022 - Current Coordinating Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2008/03/01 - 2022 Principal Investigator (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2003/01/01 - 2008/02/29 Auxiliary Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2000/01/01 - 2002/12/31 Postdoc (Research) Fundação para a Ciência e Tecnologia- FCT, Portugal
NewYork-Presbyterian/Columbia University Medical Center, United States
(...)

Positions / Appointments

Category
Host institution 		Employer
2021 - Current President Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010 - 2021 Vice-President Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2018 - 2019 Member of the Board of Directors Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2019 Member of the Scientific Council for Health and Life Sciences Fundação para a Ciência e Tecnologia- FCT, Portugal
2015 - 2019 Vice-coordinator, Program in Neurobiology and Neurological Disorders Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2019 Member of the Scientific Committee Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projects

Contract

Designation Funders
2023/01/01 - 2025/12/31 TARGET: Translating Acomys regenerative capacity
SCML2022
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Santa Casa da Misericórdia de Lisboa
Ongoing
2022/07 - 2025/06 Cytoskeletal and membrane adaptations of stretched neurons: from tension-induced growth to traumatic brain injury
DRI/India/0336/2020
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciencia e Tecnologia-FCT
Ongoing
2020/01/01 - 2024/04/30 SPINY: Characterizing Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord.
MC-39-2019
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Santa Casa da Misericórdia de Lisboa

Wings for Life Spinal Cord Research Foundation
Ongoing
2020/06/01 - 2023/05/31 NG4Leuko-Exploring neuron-glia interactions in leukodystrophies using human iPSC-based models: implication for therapy.
EJPRD/0002/2020
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e Tecnologia- FCT
Ongoing
2018/09/01 - 2022/12/31 ProREGEN- Gene delivery of active Profilin-1 to enhance axon growth capacity and enable REGENeration after spinal cord injury.
N/A
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Morton Cure Paralysis Fund Minnesota

Bluepharma

CaixaForum Barcelona
Concluded
2018/10/01 - 2021/09/30 Protection of industrial property rights for the patent ProRegen (International Patent application WO 2018/203313A1)
CCDR-N; 04/SAICT/2017
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 CCDRN
Ongoing
2018/07/01 - 2021/06/30 ACTinRING: Uncovering the mechanistic assembly and function of actin ring networks in axonal biology and pathology.
NORTE-01-0145-FEDER-028623
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e Tecnologia- FCT

CCDRN
Ongoing
2016/05/01 - 2019/12/31 Porto Neurosciences and Neurologic Disease Research Initiative at i3S.
NORTE-01-0145-FEDER-000008
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 CCDRN
Concluded
2016/01/01 - 2018/12/31 PARES– Pairing rehabilitation and Axonal REgenerative therapies towards promoting Spinal cord repair.
N/A
Principal investigator
Santa Casa da Misericórdia do Porto
Concluded
2017/04/01 - 2018/04/01 ProREGEN- Constitutively Active Profilin1: The key to Axon Growth and Regeneration
N/A
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 CCDRN
Concluded
2014/10/01 - 2016/04/30 Testing HDAC inhibitors as a therapeutic option to prevent early axonal loss in leukodystrophies.
N/A
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Acetylon Pharmaceuticals
Concluded
2013/05/01 - 2015/04/30 Modulating Actin Dynamics during axonal regeneration: the role of adducin and profilin-1
P140
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fondation internationale pour la recherche en paraplégie
Concluded
2011/11/01 - 2015/01/31 Characterization of cell-intrinsic axonal regeneration determinants and their use to promote repair after CNS injury.
HMSP-ICT/0020/2010
Principal investigator
Fundação para a Ciência e Tecnologia- FCT
Concluded
2011/01/01 - 2014/03/30 Dissecting nerve regeneration and the neuritogenic activity of TTR.
PTDC/SAU-GMG/111761/2009
Principal investigator
Fundação para a Ciencia e Tecnologia-FCT
2010 - 2012 Brainiacs: Exploration and development of Nanobody-based therapeutic solutions for disorders of the central nervous system
N/A
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 QREN- Quadro de Referência Estratégico Nacional
Concluded
2007 - 2010 Search for the molecular basis of TTR involvement in the biology of the nervous system.
PTDC/BIA-PRO/64437/2006
Principal investigator
Fundação para a Ciencia e Tecnologia-FCT
2007 - 2010 Identification of the mechanisms allowing central nervous system regeneration after a pre-conditioning injury to the peripheral nervous system.
PTDC/SAU-NEU/68470/2006
Principal investigator
Fundação para a Ciencia e Tecnologia-FCT
2007 - 2009 Finding the relevance of the proteolytic activity of transthyretin in muscle and nerve physiology.
AFM 12421
Principal investigator
AFM

Fundação para a Ciência e Tecnologia- FCT
2005 - 2007 Evaluation of cellular therapy in leukodystrophies with peripheral nervous system demyelination.
N/A
Principal investigator
Association Européenne contre les Leucodystrophies
Concluded
2005 - 2007 Role of transthyretin in the physiology of the peripheral nervous system.
N/A
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 AFM
Concluded
2002 - 2004 A novel function of transthyretin: involvement in proteolysis.
POCTI/BCI/3824/2001
Principal investigator
Fundação para a Ciencia e Tecnologia-FCT
Concluded
Outputs

Publications

Journal article
  1. Pedro Brites; Monica M. Sousa. "Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner". PLOS Biology (2022): https://doi.org/10.1371/journal.pbio.3001706.
    10.1371/journal.pbio.3001706
  2. Ana I Nascimento; Tiago F Da Silva ; Elisabete C Fernandes; Liliana L Luz ; Fernando M Mar ; Boris V Safronov ; Sousa, Monica M. Corresponding author: Sousa, Monica M. "Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain". Brain 145 5 (2022): 1632-1640.
    Accepted • 10.1093/brain/awac078
  3. Nogueira-Rodrigues, Joana; Leite SC; Pinto-Costa R; Sousa SC; Luz LL; Sintra MA; Oliveira R; et al. Corresponding author: Sousa, Monica M. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection.". Developmental Cell 57 4 (2022): 440-450.
    Published • 10.1016/j.devcel.2021.12.008
  4. Leite, Sérgio Carvalho; Pinto-Costa, Rita; Sousa, Monica Mendes. "Actin dynamics in the growth cone: a key player in axon regeneration". Current Opinion in Neurobiology 69 (2021): 11-18. http://dx.doi.org/10.1016/j.conb.2020.11.015.
    10.1016/j.conb.2020.11.015
  5. Ana Rita Costa; Monica Mendes Sousa. "The role of the membrane-associated periodic skeleton in axons". Cellular and Molecular Life Sciences (2021): https://doi.org/10.1007/s00018-021-03867-x.
    10.1007/s00018-021-03867-x
  6. Costa, Ana Rita; Sousa, Sara C; Pinto-Costa, Rita; Mateus, José C; Lopes, Cátia DF; Costa, Ana Catarina; Rosa, David; et al. "The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction". eLife 9 (2020): http://dx.doi.org/10.7554/elife.55471.
    10.7554/elife.55471
  7. Pinto-Costa, Rita; Castro Sousa, Sara; Leite, Sérgio C.; Nogueira-Rodrigues, Joana; Ferreira da Silva, Tiago; Machado, Diana; Marques, Joana Beatriz Moreira; et al. "Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration". Journal of Clinical Investigation (2020): http://dx.doi.org/10.1172/jci125771.
    10.1172/jci125771
  8. Pereira, António; Sousa, Mafalda; Almeida, Ana C.; Ferreira, Luísa T.; Costa, Ana Rita; Novais-Cruz, Marco; Ferrás, Cristina; et al. "Coherent-hybrid STED: high contrast sub-diffraction imaging using a bi-vortex depletion beam". Optics Express 27 6 (2019): 8092. http://dx.doi.org/10.1364/oe.27.008092.
    10.1364/oe.27.008092
  9. Costa, Ana Rita; Pinto-Costa, Rita; Sousa, Sara Castro; Sousa, Mónica Mendes. "The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling". Frontiers in Molecular Neuroscience 11 (2018): http://dx.doi.org/10.3389/fnmol.2018.00319.
    10.3389/fnmol.2018.00319
  10. Ana Isabel Nascimento; Fernando Milhazes Mar; Mónica Mendes Sousa. "The intriguing nature of dorsal root ganglion neurons: Linking structure with polarity and function". Progress in Neurobiology 168 (2018): 86-103. https://doi.org/10.1016/j.pneurobio.2018.05.002.
    10.1016/j.pneurobio.2018.05.002
  11. Franquinho, F.; Nogueira-Rodrigues, J.; Duarte, J.M.; Esteves, S.S.; Carter-Su, C.; Monaco, A.P.; Molnár, Z.; et al. "The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling". Cerebral cortex (New York, N.Y. : 1991) 27 3 (2017): 1732-1747. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021858395&partnerID=MN8TOARS.
    10.1093/cercor/bhx023
  12. Leite, S.C.; Sampaio, P.; Sousa, V.F.; Nogueira-Rodrigues, J.; Pinto-Costa, R.; Peters, L.L.; Brites, P.; Sousa, M.M.. "The Actin-Binding Protein a-Adducin Is Required for Maintaining Axon Diameter". Cell Reports 15 3 (2016): 490-498. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962762309&partnerID=MN8TOARS.
    10.1016/j.celrep.2016.03.047
  13. Eira, J.; Silva, C.S.; Sousa, M.M.; Liz, M.A.. "The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders". Progress in Neurobiology 141 (2016): 61-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964579571&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2016.04.007
  14. Frias, B.; Santos, J.; Morgado, M.; Sousa, M.M.; Gray, S.M.; McCloskey, K.D.; Allen, S.; Cruz, F.; Cruz, C.D.. "The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO)". Journal of Neuroscience 35 5 (2015): 2146-2160. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922372549&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.0373-14.2015
  15. Mar, F.M.; Simões, A.R.; Leite, S.; Morgado, M.M.; Santos, T.E.; Rodrigo, I.S.; Teixeira, C.A.; Misgeld, T.; Sousa, M.M.. "CNS axons globally increase axonal transport after peripheral conditioning". Journal of Neuroscience 34 17 (2014): 5965-5970. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899493785&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4680-13.2014
  16. Liz, M.A.; Mar, F.M.; Santos, T.E.; Pimentel, H.I.; Marques, A.M.; Morgado, M.M.; Vieira, S.; et al. "Neuronal deletion of GSK3ß increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2". BMC Biology 12 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927941057&partnerID=MN8TOARS.
    10.1186/1741-7007-12-47
  17. Mar, F.M.; Bonni, A.; Sousa, M.M.. "Cell intrinsic control of axon regeneration". EMBO Reports 15 3 (2014): 254-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898614180&partnerID=MN8TOARS.
    10.1002/embr.201337723
  18. da Silva, Tiago Ferreira; Eira, Jessica; Lopes, Andre T.; Malheiro, Ana R.; Sousa, Vera; Luoma, Adrienne; Avila, Robin L.; et al. "Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination". Journal of Clinical Investigation 124 6 (2014): 2560-2570.
    10.1172/JCI72063
  19. Miranda, C.O.; Teixeira, C.A.; Liz, M.A.; Sousa, V.F.; Franquinho, F.; Forte, G.; Di Nardo, P.; Pinto-Do-Ó, P.; Sousa, M.M.. "Systemic delivery of bone marrow-derived mesenchymal stromal cells diminishes neuropathology in a mouse model of Krabbe's disease". Stem Cells 29 11 (2011): 1738-1751. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054957115&partnerID=MN8TOARS.
    10.1002/stem.724
  20. Fleming, C.E.; Nunes, A.F.; Sousa, M.M.. "Transthyretin: More than meets the eye". Progress in Neurobiology 89 3 (2009): 266-276. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350302639&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2009.07.007
  21. Fleming, C.E.; Mar, F.M.; Franquinho, F.; Saraiva, M.J.; Sousa, M.M.. "Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity". Journal of Neuroscience 29 10 (2009): 3220-3232. http://www.scopus.com/inward/record.url?eid=2-s2.0-63849199799&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.6012-08.2009
  22. Fleming, C.E.; Saraiva, M.J.; Sousa, M.M.. "Transthyretin enhances nerve regeneration". Journal of Neurochemistry 103 2 (2007): 831-839. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848818080&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2007.04828.x
  23. Nunes, A.F.; Saraiva, M.J.; Sousa, M.M.. "Transthyretin knockouts are a new mouse model for increased neuropeptide Y". FASEB Journal 20 1 (2006): 166-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-30744463914&partnerID=MN8TOARS.
    10.1096/fj.05-4106fje
  24. Sousa, M.M.; Do Amaral, J.B.; Guimarães, A.; Saraiva, M.J.. "Up-regulation of the extracellular matrix remodeling genes, biglycan, neutrophil gelatinase-associated lipocalin, and matrix metalloproteinase-9 in familial amyloid polyneuropathy". FASEB Journal 19 1 (2005): 124-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244280869&partnerID=MN8TOARS.
    10.1096/fj.04-2022fje
  25. Liz, M.A.; Sousa, M.M.. "Deciphering cryptic proteases". Cellular and Molecular Life Sciences 62 9 (2005): 989-1002. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544370514&partnerID=MN8TOARS.
    10.1007/s00018-005-4544-2
  26. Liz, M.A.; Faro, C.J.; Saraiva, M.J.; Sousa, M.M.. "Transthyretin, a new cryptic protease". Journal of Biological Chemistry 279 20 (2004): 21431-21438. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442635419&partnerID=MN8TOARS.
    10.1074/jbc.M402212200
  27. Sakaguchi, T.; Yan, S.F.; Yan, S.D.; Belov, D.; Rong, L.L.; Sousa, M.; Andrassy, M.; et al. "Central role of RAGE-dependent neointimal expansion in arterial restenosis". Journal of Clinical Investigation 111 7 (2003): 959-972. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037380608&partnerID=MN8TOARS.
    10.1172/JCI200317115
  28. Sousa, M.M.; Saraiva, M.J.. "Neurodegeneration in familial amyloid polyneuropathy: From pathology to molecular signaling". Progress in Neurobiology 71 5 (2003): 385-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642575162&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2003.11.002
  29. Sousa, M.M.; Fernandes, R.; Palha, J.A.; Taboada, A.; Vieira, P.; Saraiva, M.J.. "Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro". American Journal of Pathology 161 5 (2002): 1935-1948. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036841818&partnerID=MN8TOARS.
  30. Mendes Sousa, M.; Cardoso, I.; Fernandes, R.; Guimarães, A.; João Saraiva, M.. "Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: Evidence for toxicity of nonfibrillar aggregates". American Journal of Pathology 159 6 (2001): 1993-2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035180285&partnerID=MN8TOARS.
    10.1016/S0002-9440(10)63050-7
  31. Sousa, M.M.; Saraiva, M.J.. "Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)-sensitive receptor". Journal of Biological Chemistry 276 17 (2001): 14420-14425. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035958040&partnerID=MN8TOARS.
  32. Sousa, M.M.; Yan, S.D.; Fernandas, R.; Guimarães, A.; Stern, D.; Saraiva, M.J.. "Familial amyloid polyneuropathy: Receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways". Journal of Neuroscience 21 19 (2001): 7576-7586. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035478665&partnerID=MN8TOARS.
  33. Sousa, M.M.; Norden, A.G.W.; Jacobsen, C.; Willnow, T.E.; Christensen, E.I.; Thakker, R.V.; Verroust, P.J.; Moestrup, S.K.; Saraiva, M.J.. "Evidence for the role of megalin in renal uptake of transthyretin". Journal of Biological Chemistry 275 49 (2000): 38176-38181. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034624105&partnerID=MN8TOARS.
    10.1074/jbc.M002886200
  34. De Sousa, M.M.; Vital, C.; Ostler, D.; Fernandes, R.; Pouget-Abadie, J.; Carles, D.; Saraiva, M.J.. "Apolipoprotein AI and transthyretin as components of amyloid fibrils in a kindred with apoAI Leu178His amyloidosis". American Journal of Pathology 156 6 (2000): 1911-1917. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033898466&partnerID=MN8TOARS.
    10.1016/S0002-9440(10)65064-X
  35. Sundaram, M.; Sivaprasadarao, A.; DeSousa, M.M.; Findlay, J.B.C.. "The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor". Journal of Biological Chemistry 273 6 (1998): 3336-3342. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032488909&partnerID=MN8TOARS.
    10.1074/jbc.273.6.3336

Intellectual property

Patent
  1. Sousa, Monica M. 2020. "Constitutively active profilin-1 for use in the therapy and/or treatment of a neurological disorder and/or for promoting neuronal regeneration, kit and products thereof.".
    Granted/Issued
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10 Keynote Speaker International Spinal Cord Society Annual Scientific Meeting
(Edinburgh, United Kingdom)
2023/09/13 Invited Speaker International Symposium on Cellular ecosystems in CNS injury and repair. Karolinska Institute
(Stockholm, Sweden)
2023/09 Keynote Speaker International Society for Regenerative Biology
(Vienna, Austria)
2023/07 Invited Speaker Gordon Research Conference, Neural Injury and Repair
(Barga, Italy)
2023/05 Invited Speaker AxonRepair 2023
(Montreal, Canada)
2023/05 Speaker Wings for Life Meeting
(Salzburg, Austria)
2023/03 Invited Speaker Checkpoints of CNS recovery
(Munich, Germany)
2023/03 Invited Speaker EMBO Workshop on Emerging Concepts of the Neuronal Cytoskeleton
(Santa Cruz, Chile)
2023 Invited Speaker BonnBrain meeting
(Bonn, Germany)
2022/11 Invited Seminar IMM Seminars, University of Lisbon
2022/10 Invited Speaker International Society of Developmental Biology
(Salgados, Algarve, Portugal)
2022/10 Invited Speaker Workshop on Axonal Degeneration and Regeneration
(Okinawa, Japan)
2022/06 Invited Seminar IBIMED Seminars, University of Aveiro
2022/05 Speaker EMBO workshop, Molecular Neurobiology.
(Fodele, Greece)
2021/12 Invited Speaker Sociedade Portuguesa de Neurociências
(Portugal)
2021/10 Invited Speaker Workshop on axonal degeneration and regeneration at the Okinawa Institute for Science and Technology- OIST (virtual)
(Okinawa, Japan)
2021/10 Invited Speaker Microtubules in neurons 2021. French German fall school for young scientists
(Frauenchiemsee, Germany)
2021/01 Speaker SfN Global Connectome: A Virtual Event
(online, United States)
2020/07 Invited Speaker FENS Forum 2020 (virtual)
(Glasgow (online), United Kingdom)
2020 Invited Speaker 38th Annual Meeting, Indian Academy of Neuroscience
(online, India)
2019 Invited Seminar Grenoble Institute of Neuroscience
(Grenoble, France)
2019 Invited Speaker EMBO workshop on Cell Biology of the Neuron
(Fodele, Greece)
2019 Invited Speaker EMBO workshop on Emerging Concepts of the Neuronal Cytoskeleton
(Vilaricca, Chile)
2019 Invited Speaker Membrane plasticity in tissue development and remodeling meeting, Marburg University
(Marburg, Germany)
2019 Invited Speaker Synaptic Function, Dysfunction and Repair Workshop, Discoveries Center, CEDOC
(Porto, Portugal)
2018 Invited Seminar Neuropathophysiology Insitute, Aix Marseille University
(Marseille, France)
2018 Invited Speaker Portuguese Society of Neurology
(Porto, Portugal)
2018 Invited Speaker Action talks, Portuguese Pharmaceutical Board
(Lisbon, Portugal)
2018 Invited Speaker IGC PhD Programmes, 25 Years, Fundação Calouste Gulbenkian
(Lisbon, Portugal)
2018 Invited Speaker Portuguese Spinal Cord Injury Network Meeting
(Aveiro, Portugal)
2018 Invited Speaker Krabbe Translational Network Meeting
(Tampa, United States)
2018 Invited Speaker Workshop on Integrated Glial and Neuronal Function
(Coimbra, Portugal)
2017 Session Chair 12th Young European Scientist- YES meeting
(Porto, Portugal)
2017 Invited Speaker Mediterranean Society for Neuroscience
(St Julian, Malta)
2017 Session Chair EMBO Conference, Cell Biology of the Neuron
(Fodele, Greece)
2017 Invited Speaker 1st Symposium Applied Biochemistry, University of Minho
(Braga, Portugal)
2017 Invited Speaker Portuguese Physical Medicine and Rehabilitation Society (SPMFR)
(Porto, Portugal)
2017 Invited Speaker Centro de Reabilitação do Norte
(Francelos, Portugal)
2016 Seminar Bordeaux Neurocampus
(Bordeaux, France)
2015 Seminar Instituto de Tecnologia Química e Biológica
(Oeiras, Portugal)
2015 Invited Speaker European Cytoskeleton Forum 2015
(Postjona, Slovenia)
2015 Invited Speaker EMBO workshop on Emerging Concepts of the Neuronal Cytoskeleton
(Puerto Varas, Chile)
2015 Seminar Centro de Neurociências e Biologia Celular- CNC
(Coimbra, Portugal)
2015 Seminar Instituto de Tecnologia Química e Biológica- ITQB, University of Lisbon
(Oeiras, Portugal)
2015 Invited Speaker 1st Iberian Symposium in Spinal Cord Injuries
(Alcoitão, Portugal)
2015 Session chair 5th Axon Degeneration Meeting
(Berlim, Germany)
2015 Invited Speaker ON.2 Symposium on Neurodegenerative Disorders
(Porto, Portugal)
2014 Invited Speaker VII national Meeting of Biochemistry students (ENEBIOQ)
(Lisbon, Portugal)
2014 Invited Speaker ON.2 Symposium on Neurodegenerative Disorders
(Porto, Portugal)
2013 Invited Speaker workshop on Emerging Concepts on Neuronal Cytoskeleton
(Marbella Resort, Chile)
2013 Speaker Keystone Symposia, Growing to Extremes: Cell Biology and Pathology of Axons
(Tahoe City, United States)
2013 Seminar Faculty of Medicine, University of Porto
(Porto, Portugal)
2013 Invited Speaker European Advanced Postgraduate Course on Transthyretin Associated Amyloidosis
(Porto, Portugal)
2012 Seminar Instituto de Medicina Molecular- IMM
(Lisbon, Portugal)
2012 Invited Speaker Instituto Gulbenkian de Ciência-IGC International meeting
(Lisbon, Portugal)
2012 Seminar Biocante
(Cantanhede, Portugal)
2012 Seminar Center for Molecular and Structural Biomedicine, University of Algarve
(Faro, Portugal)
2012 Invited Speaker European Advanced Postgraduate Course on Transthyretin Associated Amyloidosis
(Porto, Portugal)
2010 Keynote Portuguese Society for Neuroscience
(Braga, Portugal)
2009 Seminar
Instituto Gulbenkian de Ciência (IGC) (Oeiras, Portugal)
2007 Seminar Instituto de Tecnologia Química e Biológica- ITQB
(Oeiras, Portugal)
2007 Seminar Instituto de Medicina Molecular-IMM
(Oeiras, Portugal)
2006 Invited Speaker Hot Topics Symposium, 8th European Congress of Endocrinology
(Glasgow, United Kingdom)
2006 Seminar Instituto Gulbenkian de Ciência-IGC
(Oeiras, Portugal)
2006 Seminar 1st Sino-portuguese Workshop on Health Sciences and Biotechnology
(Hangzhou, China)
2006 Speaker Peripheral Nerve Society Meeting
(Il Ciocco, Italy)
2004 Invited Speaker Jornadas de Genética, Instituto Tecnologia Quimica e Biologica- ITQB
(Oeiras, Portugal)
2003 Speaker Peripheral Nerve Society Meeting
(Banff, Canada)
2003 Seminar Netherlands Institute for Neuroscience
(Amsterdam, Netherlands)
2003 Seminar Rudolf Magnus lecture, University Medical Center
(Utrech, Netherlands)
2002 Speaker 5th International Symposium in FAP and other TTR related disorders
(Matsumoto, Japan)
2002 Seminar Center for Neuroscience
(Coimbra, Portugal)
2001 Speaker 31st Meeting of the Society for Neuroscience
(San Diego, United States)
2001 Seminar Instituto Gulbenkian de Ciência- IGC
(Oeiras, Portugal)
2000 Speaker 72nd Meeting of the European Atherosclerosis Society
(Stocholm, Sweden)
1998 Speaker VIII International Symposium on Amyloidosis- Mayo Clinic
(Rochester, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10 - Current AcOMICS - Defining neuronal-intrinsic factors that sustain Acomys axon regeneration after spinal cord injury
Supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09 - Current Understanding axonal actin ring nucleation.
Supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/09 - Current Mechanisms of adaptation of the axonal cytoskeleton to physiological tension
Supervisor
Universidade do Porto Faculdade de Engenharia, Portugal
2020 - Current Unraveling the role of the microtubule cytoskeleton in DRG axonal asymmetry and regenerative capacity
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - Current STRETCH: Dissecting the molecular mechanisms underlying tension-driven axon growth.
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2003 - Current SUPERVISOR UNDERGRADUATES: 2022:Gonçalo Castro, Bioeng UP 2022:Ricardo Ribeiro, Bioch UP 2018:Rafaela Silva, Biochem UP 2017:Joanna Wiese, Erasmus, Medical Univ Gdansk 2015:Marta Pereira, Biochem UP 2015:Sofia Esteves, Biochem UP 2014:Joana Duarte, Biochem UP 2013:Bruno Cavalcante, Bioeng UP 2013:Yago Santos, Bioeng UP 2011:Peter McCarthy, Exchange stud, Harvard Medical School 2007:Tatiana Barros, Pathol Anatomy, UP 2005:Ana Gonçalves, Biochem, Univ Coimbra 2003:Hugo Pinheiro, Biol UP
Supervisor
2022/09 - 2023/11 Understanding the nucleation, assembly and dynamics of axonal actin rings.
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2021 - 2022 Role of orphan genes in the nervous system of the rodent Acomys cahirinus
Supervisor
Faculdade de Medicina da Universidade do Porto, Portugal
2018 - 2022 Identifying molecules and mechanisms enhancing axon growth: Acomy cahirinus as a model of mammalian regeneration
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2022 Dorsal root ganglia neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - 2020/11 Pre-clinical trial with viral delivery of Pfn1 on spinal cord injury model
Supervisor
 Neurociências (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2019 Membrane-Associated Periodic Skeleton: Investigating ßII-Spectrin as a MPS-Determining Protein and Non-muscle Myosin II as a Key Regulator of Axonal Growth
Supervisor
 Neurociências (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2019 Profilin-1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2018 New molecules and mechanisms enhancing axon growth following spinal cord injury.
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 - 2018 Microtubule organisation contributes to DRG axon asymmetry and intrinsic regenerative capacity.
Supervisor
 Neurociências (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2017 The role of profilin-1 in axon formation and regeneration.
Supervisor
 Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2017 Dorsal root ganglion neurons: the link between ultrastructure and function.
Supervisor
 Medicina (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2017 Characterization of genes with unknown function highly expressed in the spinal cord and dorsal rot ganglion
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 Exploring the role of Profilin 1 in axon formation, growth and regeneration.
Supervisor
 Bioquímica (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2015 Dissecting the role of adducin in the axonal cytoskeleton.
Supervisor
 Biologia Molecular e Celular (Master)
2014 - 2015 Modulating Actin Dynamics during Axon growth and Regeneration: the role of Profilin-1.
Supervisor
 Bioquímica (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2015 Modulating Actin Dynamics during Axonal Formation, Growth and Regeneration: the importance of adducin and profilin-1
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014 Modulating the extracellular environment during axonal regeneration following spinal cord injury.
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2013 - 2014 Modulating Actin Dynamics During Axon Formation, Growth and Regeneration:The Role of Adducin
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2014 Dissecting the role of Profilin1 in axon formation, growth and regeneration.
Supervisor
 Bioquímica (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014 Unraveling intrinsic mechanisms of nerve regeneration.
Supervisor
 Engenharia Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 - 2014 Novel Targets to Improve Axonal Regeneration in the CNS: the role of myelin lipid inhibitors, injury signals and axonal transport.
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - 2013 Evaluating injury signals and regeneration enhancers following a central nervous system injury.
Supervisor
 Biologia Celular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2012 Evaluation of the regenerative capacity in models of spinal cord injury.
Supervisor
 Medicina Experimental (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2008 - 2012 Bone marrow-derived mesenchymal stromal cell transplantation: an add-on option for Krabbe’s disease.
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 - 2010 The function of TTR in nerve and bone biology
Supervisor
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2009 - 2010 Identifying Proteins Differentially Expressed Following Conditioning Lesions
Supervisor
 Bioquímica (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 - 2010 Transthyretin as an enhancer of nerve regeneration: disclosing mechanism and biological consequences
Supervisor
 Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2004 - 2008 Influence of transthyretin on neuropeptide processing.
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2004 - 2008 The role of transthyretin in peripheral nerve biology.
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2008 Novel function of transthyretin: a cryptic protease activity.
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/07/10 - 2019/07/13 Local Organizer, European Glia Meeting, Porto on Glial Cells in heath and Disease (2019/07/10 - 2019/07/13)
Congress (Member of the Organising Committee)
2016/07/10 - 2016/07/31 Co-director, CAJAL course 2016 on Neuronal Cell Biology: Cytoskeleton and Trafficking, The CAJAL Advanced Neuroscience Training Programme, Bordeaux, France. (2016/07/10 - 2016/07/31)
Other (Co-organisor)
2015/06/04 - 2015/06/05 Member of the Organizing Committee of the XIV Meeting of the Portuguese Society for Neuroscience (SPN2015). Póvoa do Varzim, Portugal (2015/06/04 - 2015/06/05)
Congress (Member of the Organising Committee)
2013/05/30 - 2013/06/01 Member of the Scientific Committee of the XIII Meeting of the Portuguese Society for Neuroscience (SPN2013) (2013/05/30 - 2013/06/01)
Congress
2012 - 2012 Member of the organizing committee of the 7th International Meeting of the Portuguese Society for Stem cells and Cell Therapy. Porto, Portugal. April 26-27. (2012 - 2012)
Congress (Member of the Organising Committee)
2010 - 2010 Co-chair of the Workshop on “Strategies for promoting peripheral nerve regeneration”, 7th Forum of European Neuroscience, Amsterdam, The Netherlands. July 2-6. (2010 - 2010)
Workshop (Co-organisor)
2010 - 2010 Co-organizer of the Harvard Medical School Workshop on “Animal Models for Neuroscience”. Porto, Portugal. 18-22 Oct. (2010 - 2010)
Workshop (Co-organisor)
2007 - 2007 Member of the organizing committee of the 10th Meeting of the Portuguese Society for Neuroscience. Ofir, Portugal. 23-26 May. (2007 - 2007)
Congress (Member of the Organising Committee)
2004 - 2004 Chair of the workshop “Neurogenesis in the Peripheral Nervous System” - 4th Forum of European Neuroscience, Lisbon, Portugal. Jul 10-14. (2004 - 2004)
Workshop (Co-organisor)
2003 - 2003 Member of the Scientific Committee of the FENS/IBRO Summer School: “Peripheral Nervous System: from biology to disease”. Ofir, Portugal. (2003 - 2003)
Other (Member of the Scientific Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2006 Since 2006: Member of the jury of 29 PhD Thesis (national and abroad; 20 as one of the main Examiners and 9 as a part of the remaining jury members). N/A (PhD)

Association member

Society Organization name Role
2007 - 2011 Sociedade Portuguesa de Neurociências Vice-President
2005 - 2009 Sociedade Portuguesa de Células Estaminais e Terapia Celular Member of the Board

Consulting

Activity description Institution / Organization
2018 - Current Member of Editorial Boards Since 2019: Cytoskeleton, Board Member Since 2018: Associate Editor, Frontiers in Molecular Neuroscience
2004 - Current Ad-hoc reviewer scientific journals (among others): Acta Neuropathologica; Brain; Cell Reports; Current Biology; eLife; EMBO Journal; EMBO Reports; Journal of Cell Biology; Journal of Neuroscience; Nature Communications; Nature Reviews Neuroscience; Plos Biology; PNAS; Science; Science Advances

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - Current Coordinator of the module on Neuroscience- Molecular and Cell Biology PhD program (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - Current Organizer of the module “Nerve Regeneration”- Neuroscience PhD Program (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2007 - Current Lecturer on “Nerve Regeneration”- Neuroscience PhD/MSc Program (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2019 Organizer of the module “Nerve Regeneration”- GABBA PhD Program (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 Coordinator of the Module Biological System and Tissues- Molecular and Cell Biology PhD Program (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2016 Lecturer on “Cellular Engineering”, Masters Degree in Bioengineering (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - 2015 Lecturer on Stem Cell Biology (module on Molecular Biology Complements), MSc in Biochemistry (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000 - 2010 Lecturer on Proteolysis (part of the module on Protein Structure and Function), Biochemistry degree and MSc on Biochemistry (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1998 - 2000 Assistant of Biochemistry. (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2013 - Current Reviewer (National) 2016, 2017: Vice-chair, Panel of Experimental Biology and Biochemistry, PhD and Postdoc fellowships- FCT. 2013: Coordinator of the Reviewing Panel of PhD and Postdoc fellowships in Neuroscience, FCT.
2005 - Current Reviewer of International Grants: 2023: ERC- Advanced Grants; HFSP; European Science Foundation; Telethon-Italy; 2022: Rose Trees Trust; FRHE, Belgium. Since 2020: National Science Centre Poland. 2020: Deutsche Forschungsgemeinschaft. Since 2018: MRC, UK. Since 2017: Research Grants Council, Hong Kong. Since 2015: EUROSTARS. Since 2014: ANR. Since 2011: Marie Sklodowska-Curie actions. 2017: Innovation Fund Denmark. 2016: NC3Rs, Research Councils UK. 2015: Grant applications H2020. 2014: European Leukodystrophy Association (ELA).
Evaluator

Mentoring / Tutoring

Topic Student name
2022/04/01 - Current Postdoctoral Researcher Sandra Braz
2015/10 - Current Researcher (iFCT; CEEC) Márcia Liz
2016 - 2024 Ana Rita Leitão Costa- Postdoctoral Fellow (FCT SFRH/BPD/114912/2016; CEEC2022). Ana Rita Leitão Costa
2020 - 2021 Postdoctoral Researcher Ana Rita Pinto Costa
2017 - 2019 Blanca Murillo- Postdoctoral Fellow (Norte2020) Blanca Murillo
2015 - 2017 Fernando Milhazes Mar- Postdoctoral Fellow (FCT; SFRH/BPD/104503/2014) Fernando Milhazes Mar; Current position: Clinician
2009 - 2013 Pedro Brites- Postdoctoral Fellow (ELA Research Foundation) Pedro Brites; Current position: Group Leader i3S
2008 - 2013 Márcia Liz- Postdoctoral Fellow (FCT; SFRH/BPD/34811/2007) Márcia Raquel de Almeida e Liz; Current position: Team leader IBMC/i3S
2008 - 2013 Carla Teixeira- Postdoctoral Fellow (Ciência 2007) Carla Teixeira; Current position: Research Associate, Immunethep.
2008 - 2009 Luís Craveiro- Postdoctoral Fellow (FCT; SFRH/BDP/28397/2006) Luís Craveiro; Current position: Founder 5L Properties
Distinctions

Award

2022 Prémio Melo e Castro 2022
Santa Casa da Misericórdia de Lisboa, Portugal
2022 Prémio Grunenthal Dor 2021, Basic Research
Fundação Grünenthal, Portugal
2019 Prémio Melo e Castro
Santa Casa da Misericórdia de Lisboa, Portugal
2018 Bluepharma Innovation Award
Bluepharma, Portugal
2016 Prémio Melo e Castro (Team Member)
Santa Casa da Misericórdia de Lisboa, Portugal
2016 Prémio Albino Aroso (Team Member)
Santa Casa da Misericórdia do Porto, Portugal
2010 Best paper on Cellular and Molecular Neuroscience
2006 Pfizer Award in Basic Research
2005 Labmed Prize in Laboratorial Medicine
2003 BIAL- Mention of Honour (Team Member)
Fundação Bial, Portugal
2003 Mention of Honour- Neuroscience Prize
Fundação Pulido Valente, Portugal