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Identification

Personal identification

Full name
Nuno Filipe Viegas das Neves Raimundo

Citation names

  • Raimundo, Nuno

Author identifiers

Ciência ID
2B1B-2D1F-ED20
ORCID iD
0000-0002-5988-9129

Addresses

  • Rua da Couraça de Lisboa, nº89, 3º, 3000-435, Coimbra, Coimbra, Portugal (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2003/03/10 - 2009/04/07
Concluded
 Biomedical Sciences (Doktor (PhD))
Major in Biomedical Sciences
Helsingin Yliopisto Laaketieteellinen tiedekunta, Finland
"Mitochondrial malfunction in tumor formation and in neuromuscular diseases - consequences of defects in fumarate hydratase and in the respiratory chain" (THESIS/DISSERTATION)
 Excellence
1994 - 2000
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Effect of selenite supplementation on the action of diethylnitrosamine on rat tissues" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2021/03/01 - Current Principal Investigator (Research) Universidade de Coimbra, Portugal
2013 - 2020/09 Principal Investigator (Research) Georg-August-Universität Göttingen Universitätsmedizin, Germany
2008 - 2012 Postdoc (Research) Yale University Department of Pathology, United States

Teaching in Higher Education

Category
Host institution 		Employer
2000 - 2003 Assistant (Polytechnic Teacher) Escola Superior de Saúde Egas Moniz, Portugal
Projects

Grant

Designation Funders
2022/11/01 - 2026/10/30 Mitochondria-peroxisome communication axis in Parkinson’s Disease: dissecting the role of mitochondrial-derived vesicles
2022.11614.BD
Supervisor
Universidade de Coimbra, Portugal

Contract

Designation Funders
2023/02/01 - Current Different intracellular AMPK pools modulate mitochondria-ER contact sites
2022.04407.PTDC
Researcher
Universidade de Coimbra, Portugal
Ongoing
2023/09/01 - 2026/08/31 ERC-Portugal
ERC-Portugal
Principal investigator
2023/07/01 - 2026/06/30 Mito-lyso crosstalk in physiology and aging
ERC-Portugal
Principal investigator
Universidade de Coimbra, Portugal
2023/03/01 - 2026/02/28 Mitochondria-lysosome communication as a driver of age-related pathology
2022.09311.PTDC
Principal investigator
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/01/01 - 2019/12/31 Characterization of mitochondria-ER contact sites and their role in cellular signalling
SFB1190-P02
Principal investigator
Deutsche Forschungsgemeinschaft
Concluded
2014/02/01 - 2019/07/31 European Research Council - Starting Grant
337327
Principal investigator
European Commission

European Research Council
Concluded
2014 - 2016 Mitochondria and autophagy as therapeutic targets for acid maltase deficiency
sem ref
Principal investigator
Acid Maltase Deficiency Association
Concluded
Outputs

Publications

Book chapter
  1. Raimundo, Nuno; Joana Pires; Paula I. Moreira; Cristina Carvalho. Corresponding author: Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging From Fundamental Biology to Societal Impact. Elsevier, 2022.
    Published
  2. Carvalho, C.; Pires, J.F.; Moreira, P.I.; Raimundo, N.. "Disrupted cellular quality control mechanisms in aging". 359-384. 2022.
  3. Raimundo, Nuno; Fernandez-Mosquera, Lorena; Yambire, King Faisal. "Mitochondrial Signaling". In Mitochondria and Cell Death, 169-186. Springer New York, 2016.
    Published • 10.1007/978-1-4939-3612-0_9
Journal article
  1. Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko. "Lack of peroxisomal catalase affects heat shock response inCaenorhabditis elegans". Life Science Alliance (2023): https://doi.org/10.26508/lsa.202201737.
    10.26508/lsa.202201737
  2. Cláudia M. Deus; José Teixeira; Nuno Raimundo; Paolo Tucci; Fernanda Borges; Luciano Saso; Paulo J. Oliveira. "Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease". European Journal of Clinical Investigation (2022): https://doi.org/10.1111/eci.13820.
    10.1111/eci.13820
  3. Nuno Raimundo. "Feeding and lipophagy: it takes guts to deliver". The EMBO Journal (2022): https://doi.org/10.15252/embj.2022112180.
    10.15252/embj.2022112180
  4. Silvia Maglioni; Alfonso Schiavi; Marlen Melcher; Vanessa Brinkmann; Zhongrui Luo; Anna Laromaine; Nuno Raimundo; et al. "Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans". Nature Communications (2022): https://doi.org/10.1038/s41467-022-29972-4.
    10.1038/s41467-022-29972-4
  5. Riera-Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; Da Silva Padilha, M.; Fernández-Mosquera, L.; Feigenbutz, D.; et al. "Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity". Life Science Alliance 5 3 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85122904549&partnerID=MN8TOARS.
    10.26508/lsa.202101185
  6. "A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.". Redox biology (2021): https://europepmc.org/articles/PMC8220403.
    10.1016/j.redox.2021.102037
  7. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  8. Mkrtchyan, Garik V.; Abdelmohsen, Kotb; Andreux, Pénélope; Bagdonaite, Ieva; Barzilai, Nir; Brunak, Søren; Cabreiro, Filipe; et al. "ARDD 2020: from aging mechanisms to interventions". Aging (2020): http://dx.doi.org/10.18632/aging.202454.
    10.18632/aging.202454
  9. Sathyanarayanan, Udhayabhaskar; Musa, Marina; Bou Dib, Peter; Raimundo, Nuno; Milosevic, Ira; Krisko, Anita. "ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-19104-1.
    10.1038/s41467-020-19104-1
  10. Zhao, Jingjing; Li, Gen; Zhao, Xuan; Lin, Xin; Gao, Yunge; Raimundo, Nuno; Li, Geng-Lin; et al. "Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss". Aging (2020): http://dx.doi.org/10.18632/aging.102977.
    10.18632/aging.102977
  11. Gowrisankaran, Sindhuja; Houy, Sébastien; del Castillo, Johanna G. Peña; Steubler, Vicky; Gelker, Monika; Kroll, Jana; Pinheiro, Paulo S.; et al. "Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-14993-8.
    10.1038/s41467-020-14993-8
  12. Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno; Oliveira, Paulo J.. "Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 3 (2020): 165615. http://dx.doi.org/10.1016/j.bbadis.2019.165615.
    Open access • Published • 10.1016/j.bbadis.2019.165615
  13. Deus, Cláudia M.; Yambire, King Faisal; Oliveira, Paulo J.; Raimundo, Nuno. "Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration". Trends in Molecular Medicine 26 1 (2020): 71-88. http://dx.doi.org/10.1016/j.molmed.2019.10.009.
    Open access • Published • 10.1016/j.molmed.2019.10.009
  14. Eid, N.; Menon, M.B.; Thomes, P.; Zeng, T.; Raimundo, N.; Fernandez-Checa, J.C.; Wang, L.; et al. "Editorial: Autophagy and related transcription factors in liver and gut diseases". Frontiers in Pharmacology 10 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079427744&partnerID=MN8TOARS.
    10.3389/fphar.2019.01610
  15. Yambire, King Faisal; Rostosky, Christine; Watanabe, Takashi; Pacheu-Grau, David; Torres-Odio, Sylvia; Sanchez-Guerrero, Angela; Senderovich, Ola; et al. "Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo". eLife 8 (2019): http://dx.doi.org/10.7554/elife.51031.
    Open access • Published • 10.7554/elife.51031
  16. Fonseca, Tiago Branco; Sánchez-Guerrero, Ángela; Milosevic, Ira; Raimundo, Nuno. "Mitochondrial fission requires DRP1 but not dynamins". Nature 570 7761 (2019): E34-E42. http://dx.doi.org/10.1038/s41586-019-1296-y.
    Open access • Published • 10.1038/s41586-019-1296-y
  17. Raimundo, Nuno; Krisko, Anita. "Editorial: Mitochondrial Communication in Physiology, Disease and Aging". Frontiers in Cell and Developmental Biology 7 (2019): http://dx.doi.org/10.3389/fcell.2019.00054.
    Open access • Published • 10.3389/fcell.2019.00054 • Editor
  18. Barriocanal-Casado, Eliana; Hidalgo-Gutiérrez, Agustín; Raimundo, Nuno; González-García, Pilar; Acuña-Castroviejo, Darío; Escames, Germaine; López, Luis C.. "Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease". EBioMedicine 42 (2019): 511-523. http://dx.doi.org/10.1016/j.ebiom.2019.03.025.
    Open access • Published • 10.1016/j.ebiom.2019.03.025
  19. Fernandez-Mosquera, Lorena; Yambire, King Faisal; Couto, Renata; Pereyra, Leonardo; Pabis, Kamil; Ponsford, Amy H.; Diogo, Cátia V.; et al. "Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis". Autophagy 15 9 (2019): 1572-1591. http://dx.doi.org/10.1080/15548627.2019.1586256.
    Open access • Published • 10.1080/15548627.2019.1586256
  20. Yambire, King Faisal; Fernandez-Mosquera, Lorena; Steinfeld, Robert; Mühle, Christiane; Ikonen, Elina; Milosevic, Ira; Raimundo, Nuno. "Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases". eLife 8 (2019): http://dx.doi.org/10.7554/elife.39598.
    Open access • Published • 10.7554/elife.39598
  21. King Faisal Yambire; Lorena Fernandez-Mosquera; Robert Steinfeld; Christiane Mühle; Elina Ikonen; Ira Milosevic; Nuno Raimundo. "Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases". eLife (2019): https://doi.org/10.7554/eLife.39598.
    10.7554/eLife.39598
  22. Musa, Marina; Peric, Matea; Bou Dib, Peter; Sobocanec, Sandra; Šaric, Ana; Lovric, Anita; Rudan, Marina; et al. "Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling". Aging 10 9 (2018): 2407-2427. http://dx.doi.org/10.18632/aging.101560.
    Open access • Published • 10.18632/aging.101560
  23. Simão, Daniel; Silva, Marta M.; Terrasso, Ana P.; Arez, Francisca; Sousa, Marcos F.Q.; Mehrjardi, Narges Z.; Šaric, Tomo; et al. "Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation". Stem Cell Reports 11 2 (2018): 552-564. http://dx.doi.org/10.1016/j.stemcr.2018.06.020.
    Open access • Published • 10.1016/j.stemcr.2018.06.020
  24. Cátia V. Diogo; King Faisal Yambire; Lorena Fernández Mosquera; Tiago Branco F.; Nuno Raimundo. "Mitochondrial adventures at the organelle society". Biochemical and Biophysical Research Communications 500 1 (2018): 87-93. https://doi.org/10.1016/j.bbrc.2017.04.124.
    Published • 10.1016/j.bbrc.2017.04.124
  25. Raimundo, Nuno; Kriško, Anita. "Cross-organelle communication at the core of longevity". Aging 10 1 (2018): 15-16. http://dx.doi.org/10.18632/aging.101373.
    Open access • Published • 10.18632/aging.101373 • Editor
  26. Peric, Matea; Lovric, Anita; Šaric, Ana; Musa, Marina; Bou Dib, Peter; Rudan, Marina; Nikolic, Andrea; et al. "TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan". Aging Cell 16 5 (2017): 994-1005. http://dx.doi.org/10.1111/acel.12623.
    Open access • Published • 10.1111/acel.12623
  27. Fernández-Mosquera, Lorena; Diogo, Cátia V.; Yambire, King Faisal; Santos, Gabriela L.; Luna Sánchez, Marta; Bénit, Paule; Rustin, Pierre; et al. "Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/srep45076.
    Open access • Published • 10.1038/srep45076
  28. John D. Murdoch; Christine M. Rostosky; Sindhuja Gowrisankaran; Amandeep S. Arora; Sandra-Fausia Soukup; Ramon Vidal; Vincenzo Capece; et al. "Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System". Cell Reports 17 4 (2016): 1071-1086. http://dx.doi.org/10.1016/j.celrep.2016.09.058.
    Published • 10.1016/j.celrep.2016.09.058
  29. Raimundo, Nuno; Fernández-Mosquera, Lorena; Yambire, King Faisal; Diogo, Cátia V.. "Mechanisms of communication between mitochondria and lysosomes". The International Journal of Biochemistry & Cell Biology 79 (2016): 345-349. http://dx.doi.org/10.1016/j.biocel.2016.08.020.
    Open access • Published • 10.1016/j.biocel.2016.08.020
  30. Peric, Matea; Dib, Peter Bou; Dennerlein, Sven; Musa, Marina; Rudan, Marina; Lovric, Anita; Nikolic, Andrea; et al. "Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep28751.
    Open access • 10.1038/srep28751
  31. McKay, Sharen E.; Yan, Wayne; Nouws, Jessica; Thormann, Maximilian J.; Raimundo, Nuno; Khan, Abdul; Santos-Sacchi, Joseph; Song, Lei; Shadel, Gerald S.. "Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness". The American Journal of Pathology 185 12 (2015): 3132-3140. http://dx.doi.org/10.1016/j.ajpath.2015.08.014.
    Published • 10.1016/j.ajpath.2015.08.014
  32. West, A. Phillip; Khoury-Hanold, William; Staron, Matthew; Tal, Michal C.; Pineda, Cristiana M.; Lang, Sabine M.; Bestwick, Megan; et al. "Mitochondrial DNA stress primes the antiviral innate immune response". Nature 520 7548 (2015): 553-557. http://dx.doi.org/10.1038/nature14156.
    Published • 10.1038/nature14156
  33. Raimundo, Nuno. "Mitochondrial pathology: stress signals from the energy factory". Trends in Molecular Medicine 20 5 (2014): 282-292. http://dx.doi.org/10.1016/j.molmed.2014.01.005.
    Published • 10.1016/j.molmed.2014.01.005
  34. Schroeder, Elizabeth A.; Raimundo, Nuno; Shadel, Gerald S.. "Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity". Cell Metabolism 17 6 (2013): 954-964. http://dx.doi.org/10.1016/j.cmet.2013.04.003.
    Open access • Published • 10.1016/j.cmet.2013.04.003
  35. Raimundo, Nuno; Song, Lei; Shutt, Timothy E.; McKay, Sharen E.; Cotney, Justin; Guan, Min-Xin; Gilliland, Thomas C.; et al. "Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness". Cell 148 4 (2012): 716-726. http://dx.doi.org/10.1016/j.cell.2011.12.027.
    Published • 10.1016/j.cell.2011.12.027
  36. Raimundo, Nuno; Baysal, Bora E.; Shadel, Gerald S.. "Revisiting the TCA cycle: signaling to tumor formation". Trends in Molecular Medicine 17 11 (2011): 641-649. http://dx.doi.org/10.1016/j.molmed.2011.06.001.
    Published • 10.1016/j.molmed.2011.06.001
  37. Tyynismaa, Henna; Carroll, Christopher J.; Raimundo, Nuno; Ahola-Erkkilä, Sofia; Wenz, Tina; Ruhanen, Heini; Guse, Kilian; et al. "Mitochondrial myopathy induces a starvation-like response". Human Molecular Genetics 19 20 (2010): 3948-3958. http://dx.doi.org/10.1093/hmg/ddq310.
    Open access • Published • 10.1093/hmg/ddq310
  38. Raimundo, Nuno; Shadel, Gerald S.. "A "radical" mitochondrial view of autophagy-related pathology". Aging 1 4 (2009): 354-356. http://dx.doi.org/10.18632/aging.100037.
    Open access • Published • 10.18632/aging.100037
  39. Raimundo, N; Vanharanta, S; Aaltonen, L A; Hovatta, I; Suomalainen, A. "Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas". Oncogene 28 9 (2009): 1261-1273. http://dx.doi.org/10.1038/onc.2008.472.
    Open access • Published • 10.1038/onc.2008.472
  40. Raimundo, Nuno; Ahtinen, Jouni; Fumic, Ksenija; Baric, Ivo; Remes, Anne M.; Renkonen, Risto; Lapatto, Risto; Suomalainen, Anu. "Differential metabolic consequences of fumarate hydratase and respiratory chain defects". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1782 5 (2008): 287-294. http://dx.doi.org/10.1016/j.bbadis.2008.01.008.
    Open access • Published • 10.1016/j.bbadis.2008.01.008
  41. Guarino, Maria P.; Afonso, Ricardo A.; Raimundo, Nuno; Raposo, João F.; Macedo, M. Paula. "Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action". American Journal of Physiology-Gastrointestinal and Liver Physiology 284 4 (2003): G588-G594. http://dx.doi.org/10.1152/ajpgi.00423.2002.
    Open access • Published • 10.1152/ajpgi.00423.2002
Thesis / Dissertation
  1. Wieciorek-Pluciennik, Katarzyna. "Effect of CLN3-loss-of-function on cellular metabolism and signalling". PhD, 2022. http://dx.doi.org/10.53846/goediss-9277.
    10.53846/goediss-9277
  2. Couto, Renata Lopes Familiar. "Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites". PhD, 2019. http://dx.doi.org/10.53846/goediss-7742.
    10.53846/goediss-7742
  3. Pereyra, Leonardo Gabriel. "Organelle dysfunction modulates cholesterol biosynthesis pathway". PhD, 2019. http://dx.doi.org/10.53846/goediss-7666.
    10.53846/goediss-7666
  4. Yambire, King Faisal. "Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function". PhD, 2018. http://dx.doi.org/10.53846/goediss-7142.
    10.53846/goediss-7142
  5. Fonseca, Tiago Alexandre Branco. "The role of dynamins and dynamin-related protein 1 (Drp 1) in the regulation of mitochondrial and peroxisomal fission.". Master, Universidade de Coimbra, 2017. http://hdl.handle.net/10316/82986.
  6. Fernández Mosquera, Lorena. "Mechanisms of communication from mitochondria to lysosomes". PhD, 2017. http://dx.doi.org/10.53846/goediss-6214.
    10.53846/goediss-6214

Intellectual property

Patent
  1. Raimundo, Nuno. 2010. "Dysfunction of the mitochondrial respiratory chain, methods for diagnosis, treatment and follow-up".
    Granted/Issued

Other

Other output
  1. Cx43 promotes exocytosis of damaged lysosomes through actin remodelling. 2022. Domingues, N.; Catarino, S.; Cristovao, B.; Rodrigues, L.; Filomena, C.; Sarmento, M.J.; Zuzarte, M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85146213610&partnerID=MN8TOARS.
    10.21203/rs.3.rs-2277227
  2. Functional peroxisomes are required for heat shock-induced hormesis in Caenorhabditis elegans. 2021. Musa, M.; Milosevic, I.; Raimundo, N.; Krisko, A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114259983&partnerID=MN8TOARS.
    10.1101/2021.07.13.452156
  3. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. 2020. Silvia Maglioni; Alfonso Schiavi; Marlen Melcher; Vanessa Brinkmann; Zhongrui Luo; Anna Laromaine; Nuno Raimundo; et al. https://doi.org/10.1101/2020.02.20.957225.
    10.1101/2020.02.20.957225
  4. Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity. 2019. Tillman Schaefer; Irene Riera-Tur; Daniel Hornburg; Archana Mishra; Lorena Fernández-Mosquera; Nuno Raimundo; Matthias Mann; et al. https://doi.org/10.1101/2019.12.16.877431.
    10.1101/2019.12.16.877431
  5. Endophilin-A controls recruitment, priming and fusion of neurosecretory vesicles. 2019. Ira Milosevic; Sindhuja Gowrisankaran; Vicky Steubler; Sebastien Houy; Johanna G. Pena del Castillo; Monika Gelker; Jana Kroll; et al. https://doi.org/10.1101/540864.
    10.1101/540864
  6. Impaired lysosomal acidification triggers iron deficiency, necrotic cell death and inflammation in vivo. 2019. Yambire, K.F.; Rostosky, C.; Watanabe, T.; Pacheu-Grau, D.; Torres-Odio, S.; Sanchez-Guerrero, A.; Senderovich, O.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095624444&partnerID=MN8TOARS.
    10.1101/710798
  7. Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. 2018. King Faisal Yambire; Lorena Fernandez-Mosquera; Robert Steinfeld; Christiane Muehle; Elina Ikonen; Ira Milosevic; Nuno Raimundo. https://doi.org/10.1101/381376.
    10.1101/381376
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/12 Mitochondria and lysosomal malfunction involve metabolic rewiring and organelle crosstalk adaptation in mammalian cells and tissues CellBio 2022, Annual meeting of the American Society for Cell Biology
American Society for Cell Biology (Washington DC, United States)
2022/10 Mitochondrial malfunction engages lysosomes to modify cellular nutrient signaling Healthy Aging Alliance 12th annual meeting
Healthy Aging Alliance (Minneapolis, United States)
2022/06 Mitochondrial dynamics in cardiovascular injury Zagreb Spring Symposium of Applied Cardiovascular Physiology and Treatment
Dr. Ina Filipovic-Grcic (Zagreb, Croatia)
2022/06 AMPK bosses organelles around to rewire cellular metabolism 56th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Bari, Italy)
2022/03 Autophagosome accumulation triggers a signaling response that modifies organelle homeostasis and metabolism Gordon Research Conference Autophagy in Stress, Development and Disease
Gordon Research Conference (Ventura, CA, United States)
2021/09 AMPK regulates interactions between mitochondria, lysosomes and ER 11th International Meeting on AMPK
(Evian-les-bains, France)
2019/09 Lysosomes rule with an iron fist LYSOCIL Symposium
Prof. Miguel Seabra (Lisbon, Portugal), Dr. Cláudia Almeida (Lisbon, Portugal), Dr. Helena Vieira (Lisbon, Portugal), Dr. Otília Vieira (Lisbon, Portugal). (Lisboa, Portugal)
2019/02 Mitochondrial Malfunction Impairs Lysosomal Hydrolysis via AMPK-PtdIns(3,5)P2 Keystone Autophagy
Keystone Symposia (Santa Fé, United States)
2019/01 Impact of Mitochondrial Function in Aging is Mediated by Impaired Lysosomes Keystone Mitochondria in Aging and Age-Related Disease
Keystone Symposia (Keystone, CO, United States)
2018/10 Crosstalk between mitochondria and lysosomes orchestrates lipid metabolism. Cold Spring Harbor Laboratory Meeting Nutrient Signaling
Cold Spring Harbor Laboratory (Cold Spring Harbor, NY, United States)
2018/02 Mechanisms of cross-regulation between mitochondria and lysosomes Weizmann Conference Emerging Concepts in Mitochondrial Biology
(Rehovot, Israel)
2018 Cross-regulatory mechanisms between mitochondria and lysosomes 52nd Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Barcelona, Spain)
2017 Mitochondria and lysosomes – united we stand FEBS3+ Meeting
FEBS (Barcelona, Spain)
2017 Lysosomal malfunction impairs mitochondria – a unifying mechanism in lysosomal storage diseases Gordon Research Conference in Lysosomal Diseases
Gordon Research Conferences (Lucca)
2017 Lysosomal malfunction impairs mitochondria via a transcriptional mechanism 21st European Study Group for Lysosomal Diseases
European Study Group for Lysosomal Diseases (Lyon, France)
2017 AMPK regulates lysosomal function and coordinates the crosstalk between mitochondria and lysosomes 3rd European Symposium on AMPK
3rd European Symposium on AMPK (Porquerolles, France)
2014 Mitochondrial signaling - the energy factory takes control of the boardroom Mechanisms of Signal Transduction
Associazione di Biologia Cellulare e del Differenziamento (Padova, Italy)
2014 Mitochondrial malfunction elicits a metabolic code which modulates the signaling environment EMBO Frontiers in Metabolism: From Molecular Physiology to Systems Medicine
EMBO (Heidelberg, Germany)
2014 Mitochondria, the social organelle: interactions between mitochondria and other cellular organelles in physiology and disease EuroMIT 9th Conference in Mitochondrial Research
(Tampere, Finland)
2013 AMPK-autophagy pathway determines myopathy formation in response to mitochondrial malfunction EMBO Workshop Molecular mechanisms of muscle growth and wasting in health and disease,
(Ascona, Switzerland)
2013 Tissue-specificity of mitochondrial pathology is determined by the AMPK-autophagy pathway. Cell Symposium Mitochondria: from signalling to disease
(Lisboa, Portugal)
2012 Mitochondrial Stress Triggers E2F1 Apoptotic Signaling to Cause Deafness – Insights into Tissue-Specific Mechanisms Keystone Symposium Mitochondrial Dynamics and Function, and Keystone Symposium Cell Death Pathways: Beyond Apoptosis (Joint Session)
(Banff, Canada)
2012 Mitochondrial Stress Triggers E2F1 Apoptotic Signaling to Cause Deafness UMDF Symposium 2012
United Mitochondrial Disease Foundation (Bethesda, MA, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/11/01 - Current Mitochondria-peroxisome communication axis in Parkinson’s Disease: dissecting the role of mitochondrial-derived vesicles
Supervisor
Universidade de Coimbra, Portugal
2018 - 2022 Effect of CLN3-loss-of-function on cellular metabolism and signalling
Supervisor
Georg-August-Universität Göttingen, Germany
2016 - 2019 Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites
Supervisor
Georg-August-Universität Göttingen, Germany
2015 - 2019 Organelle dysfunction modulates cholesterol biosynthesis pathway
Supervisor
Georg-August-Universität Göttingen, Germany
2014 - 2018 Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function
Supervisor
Georg-August-Universität Göttingen, Germany
2016 - 2017 The role of dynamins and dynamin-related protein 1 in the regulation of mitochondrial and peroxisomal division
Supervisor
Universidade de Coimbra, Portugal
2016 - 2017 Links between defective endocytosis and mitochondria
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2017 Mechanisms of communication from mitochondria to lysosomes
Supervisor
Georg-August-Universität Göttingen, Germany

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/01 - Current MITOtalks - biweekly online seminar series focused on mitochondrial biology (2021/01)
Seminar (Co-organisor)
2019/03 - Current organized a symposium within the German Neuroscience Society 2019, with the theme "Mitochondria and neurodegeneration". Invited speakers: Thomas Langer (MPI-AGE, Cologne, DE), Elena Rugarli (CECAD, Cologne, DE), Nektarios Tavernarakis (Heraklion, GR), Patrik Verstreken (VIB Leuven, BE) and two selected abstracts from early-career researchers. (2019/03)
Symposium (Co-organisor)
 Neurowissenschaftliche Gesellschaft, Germany
2021/12/01 - 2021/12/10 Metabolic Signaling symposium at ASBC/EMBO CellBio 2021 (2021/12/01 - 2021/12/10)
Conference (Co-organisor)
2020/12 - 2020/12 Organizer of a Special Interest Subgroup at the Annual Meeting of the American Society for Cell Biology (Cell Bio 2020). The Subgroup is titled: “Functional crosstalk of mitochondria and lysosomes in health and disease” (2020/12 - 2020/12)
Congress (Co-organisor)
 American Society for Cell Biology, United States

EMBO Press, Germany

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/03 - 2020/03 Doctoral Program in Experimental Biology and Biomedicine (PDBEB) 2019/2020 Edition The Avenging Metabolism in Human Disease: Endgame!
Workshop
 Doctoral Program in Experimental Biology and Biomedicine (PDBEB) 2019/2020 Edition The Avenging Metabolism in Human Disease: Endgame!
Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/11/22 The regulatory role of BCL2L13 in skeletal muscle inter-organelle communication
(Thesis) Main arguer
 Dogan Grepper (PhD)
Université de Lausanne, Switzerland
2019 Organelle dysfunction modulates cholesterol biosynthesis pathways
Supervisor
 Leonardo Gabriel Pereyra (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2019 Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites
Supervisor
 Renata Familiar Lopes Couto (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2019 The impact of the integrated stress response on DNA replication
(Thesis) Arguer
 Josephine Ann Mun Yee Choo (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2018 OPA1 deficiency drives muscle inflammation
(Thesis) Arguer
 Aida Rodriguez (PhD)
Universitat Autònoma de Barcelona, Spain
2018 The role of alpha-synuclein on transcriptional deregulation in Parkinson disease
(Thesis) Arguer
 Isabel Paiva de Carvalho (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2018 The role of mammalian TRC40 in membrane-protein targeting and chaperoning
(Thesis) Arguer
 Francesco Javier Coy Vergara (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2018 Onset and progression of neurodegeneration in mouse models for defective endocytosis
(Thesis) Arguer
 Christine Rostosky (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2017 Mechanisms of communication between mitochondria and lysosomes
Supervisor
 Lorena Fernandez-Mosquera (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2017 Lysosomal and mitochondrial crosstalk – the role of lysosomal signaling in mitochondrial biogenesis and function
Supervisor
 King Faisal Yambire (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2016 Identification and characterization of importin 13 substrates
(Thesis) Arguer
 Inke Baade (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2016 Transport of tail-anchored proteins to the inner nuclear membrane
(Thesis) Arguer
 Janine Pfaff (PhD)
Universitätsmedizin Göttingen Institut für Molekularbiologie, Germany
2016 Cellular and subcellular analysis of peripheral neuropathy caused by peroxisomal dysfunction in mice
(Thesis) Arguer
 Sandra Kleineke (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany
2016 The role of the mammalian GET pathway in the mouse liver
(Thesis) Arguer
 Lena Musiol (PhD)
Georg-August-Universität Göttingen Universitätsmedizin, Germany

Committee member

Activity description
Role 		Institution / Organization
2018/09 - 2021/08 Part of a PhD student committee for the student Dogan Grepper
Member
 Université de Lausanne Faculté de biologie et médecine, Switzerland

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/02 - 2020/06 Doencas Metabolicas Doencas Metabolicas (Mestrado) Universidade de Aveiro, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current EMBO Reports (1469-3178) EMBO
2019 - Current Science Advances
2019 - Current Nature Metabolism (2522-5812) Springer Science and Business Media LLC
2018 - Current eLife (2050-084X) "eLife Sciences Publications, Ltd."
2017 - Current The EMBO Journal (1460-2075) EMBO
2017 - Current Experimental & Molecular Medicine (2092-6413) Springer Science and Business Media LLC
2017 - Current Frontiers in Pharmacology (1663-9812) Frontiers Media SA
2017 - Current Frontiers in Molecular Neuroscience
2017 - Current Chemical Science
2017 - Current Autophagy (1554-8635) Landes Bioscience
2016 - Current Cellular and Molecular Life Sciences (1420-9071) Springer-Verlag
2016 - Current American Journal of Physiology - Cell Physiology
2016 - Current Experimental and Molecular Pathology (1096-0945) Elsevier
2016 - Current Aging
Distinctions

Award

2022 Prix Tremplin Mariano Gago
Institut de France, France
2014 Acid Maltase Deficiency Association Research Award
Acid Maltase Deficiency Association, United States
2012 Postdoctoral Fellowship
United Mitochondrial Disease Foundation, United States
2003 Award Ernesto Roma
Associacao Protectora dos Diabeticos de Portugal, Portugal

Boehringer Ingelheim Corp USA, United States

Other distinction

2012 Travel Grant
Keystone Symposia, United States
2007 best contribution by a PhD student/post-doc to the FEBS Advanced Lecture Course - Mitochondria in cell life, death and disease