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Michele Claire Breton. Completed her PhD in Cellular and Molecular Biology on 2011/06/22 from the Federal University of Rio Grande do Sul (Porto Algre, RS, Brazil), Master in Genetics and Breeding on 2003/02/18 from the State University of Londrina (Londrina, PR; Brazil), Postgraduate Certificate in Genetics Applied to Teaching on 2001/06/17 from the State University of Maringá (Maringá, PR, Brazil), Bachelor in Biological Sciences on 1999/12/15 from the State University of Londrina and Bachelor in Biological Sciences on 2000/12/15 from the State University of Londrina. She has published 9 articles in specialized journals. Has 1 book chapter(s). Co-supervised 2 master's dissertation(s). Participates and/or has participated as a Postdoctoral Fellow in 1 project(s), Technical Development in 1 project(s) and Postdoctoral Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology, Agricultural Sciences with emphasis on Agricultural and Food Biotechnology with emphasis on Agricultural Biotechnology and Food Biotechnology and Exact Sciences with emphasis on Computer and Information Sciences with emphasis on Bioinformatics.
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Identification

Personal identification

Full name
Michele Claire Breton
Gender
Female

Citation names

  • Breton, Michele
  • Breton, Michele C.
  • Breton, Michele Claire

Author identifiers

Ciência ID
2C11-B433-9F9B
Google Scholar ID
https://scholar.google.com.br/citations?hl=pt-BR&user=LtqQq9EAAAAJ&view_op=list_works&gmla=AJ1KiT3BqhBBWue_vgPvrfQmzaHfLkttzsDMWq5CZSn5GEesj5Od0TC5tK9afimVs8yScixkIktK2DshLrcaPxgGkXg

Email addresses

  • michele.breton@ubi.pt (Professional)
  • michele.breton@labfit.eu (Professional)

Telephones

Mobile phone
  • 936917982 (Personal)

Addresses

  • Edifício UBIMEDICAL, Estrada Municipal 506 , 6200-284, Covilhã, Castelo Branco, Portugal (Professional)

Websites

Knowledge fields

  • Agrarian Sciences - Agrarian and Food Biotechnology
  • Medical and Health Sciences - Medical Biotechnology
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
Education
Degree Classification
2008/03/08 - 2015/06/22
Concluded
 PhD in Cellular and Molecular Biology (Doctor)
Major in Plant biotechnology
Universidade Federal do Rio Grande do Sul, Brazil
"Study of the transcriptome in Eucalyptus grandis flowers" (THESIS/DISSERTATION)
 concept 7.0 at CAPES
2001/03/08 - 2003/02/18
Concluded
 Master in Genetics and Breeding (Master)
Major in Plant biotecnologia
Universidade Estadual de Londrina, Brazil
""Differential gene expression in four soybean cultivars [Glycine max (L.) Merrill] subjected to two photoperiods"." (THESIS/DISSERTATION)
 Concept 5.0 at CAPES
1999/12/05 - 2001/06/17
Concluded
 Specialization in Genetics Applied to Teaching (Postgraduate Certificate)
Major in Ensino de genética
Universidade Estadual de Maringá, Brazil
1995/02/01 - 2000/12/15
Concluded
 Biological Sciences (Bachelor)
Major in Genética - mutagênese
Universidade Estadual de Londrina, Brazil
"Evaluation of the mutagenicity of the drug Prozac, with and without the addition of vitamins A and C, in V79 mammalian cells" (THESIS/DISSERTATION)
1995/02/01 - 1999/12/15
Concluded
 Biological Sciences (Licence)
Major in Genética
Universidade Estadual de Londrina, Brazil
Affiliation

Science

Category
Host institution 		Employer
2019/03/01 - 2022/02/28 Auxiliary Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/02/01 - 2015/01/31 Postdoc (Research) Centro de Citricultura Sylvio Moreira, Brazil
Centro de Citricultura Sylvio Moreira, Brazil
2004/06 - 2005/11 Contracted Researcher (Research) Alellyx Applied Genomics S.A., Brazil
Alellyx Applied Genomics S.A., Brazil
2003 - 2004 Research Trainee (Research) Centro de Biotecnologia da UFRGS, Brazil
Centro de Biotecnologia da UFRGS, Brazil

Teaching in Higher Education

Category
Host institution 		Employer
2019 - 2020 Tutor (University Teacher) Faculdade de Ciências da Saúde UBI, Portugal
Faculdade de Ciências da Saúde UBI, Portugal
2014/02 - 2015/12 Assistant Professor (University Teacher) Faculdade Anhanguera de Leme, Brazil
Faculdade Anhanguera de Leme, Brazil

Other Careers

Category
Host institution 		Employer
2023/07/10 - Current Assistente (Farmacêutica) Health Products Research and Development Lda, Portugal
Health Products Research and Development Lda, Portugal
2022/04/20 - 2023/06/30 Técnico Superior (Técnico Superior) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
1995/11 - 2001/03 Assistente (Médica) Prefeitura de Londrina, Brazil
Centrolab - Laboratório de Análises Clínicas, Brazil
1994/04/05 - 1995/04/04 Técnico de Informática-Adjunto Nível 3 (Técnico de informática) Prefeitura de Londrina, Brazil
Departamento de Informação em Saúde, Brazil
Projects

Grant

Designation Funders
2013/02/01 - 2015/01/31 Dynamic analysis of the citrus transcriptome in response to Candidatus Liberibacter asiaticus, the causal agent of Huanglongbing (ex-greening)
12/20667-7
Post-doc Fellow
Centro de Citricultura Sylvio Moreira, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2003 - 2004 Implementation of the Bioinformatics Laboratory in the Southern Network for Genome Analysis and Structural Biology
0000
Technical development
Centro de Biotecnologia da UFRGS, Brazil
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded

Contract

Designation Funders
2019/03/01 - 2022/02/28 Ischemic cholangiopathy in conditions of liver dysfunction
POCI-01-0145-FEDER-028956
Post-doc
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
Outputs

Publications

Book chapter
  1. Dalio, Ronaldo J. D.; Magahães, Diogo M.; Atílio, Lísia B.; Rodrigues, Carolina M.; Breton, Michele C.; Pichi, Simone; Paschoati, Sérgio F.; Machado, Marcos A.. "Effectors in plant-pathogen interactions". In Revisão Anual de Pataologia de Plantas, 25-68. Passo Fundo - RS, Brazil: Sociendade Brasileira de Fitopatologia de Plantas, 2014.
    Published
Conference abstract
  1. d'Almeida, Gabriel; Breton, Michèle; Camargo, Sandro; Frazzon, Jeverson; Pasquali, Giancarlo. "Phylogenetic comparative and expression analysis of genes encoding dof transcription factors from Eucalyptus grandis". Paper presented in IUFRO Tree Biotechnology Conference 2011: From Genomes to Integration and Delivery, Arraial D´Ajuda BA, 2011.
    Published • 10.1186/1753-6561-5-s7-p159
Conference poster
  1. DINIZ, CATARINA; Breton, Michele; ADRIANA OLIVEIRA DOS SANTOS. "EVALUATION OF RALGPS2 EXPRESSION IN FREE HUMAN CANCER DATASETS". Paper presented in IV International Congress in Health Science Research – Challenges from Research to Clinics, 2023.
  2. Fernandes, Mariana; Gaspar, Carlos; Breton, Michele Claire; Martinez-de-Oliveira, José; Oliveira, Ana Cristina Palmeira de; Rolo, Joana. "Niche-specific genes of vaginal Candida albicans isolates: an in-silico analysis - Poster". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022.
  3. Mariana Zagalo Fernandes; Carlos Gaspar; Breton, Michele; Martinez-de-Oliveira, José; Oliveira, Ana Cristina Palmeira de; Rolo, Joana. Corresponding author: Rolo, Joana. "Niche-specific genes of vaginal Candida albicans isolates: an in-silico analysis.". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022.
  4. Quelhas, Patricia; Breton, Michele Claire; Cipriano, Maria Augusta; Shivakumar, Pranav; Bezerra, Jorge ; Vieira, Sandra; Kieling, Carlos; Verde, Ignacio; dos Santos, Jorge Luiz. "Ischemic cholangiopathy in biliary atresia: immunohistochemical and molecular evidences". Paper presented in EASl International Liver Congress, 2021.
Journal article
  1. Quelhas, Patrícia; Breton, Michele Claire; Oliveira, Rui Caetano; Cipriano, Maria Augusta; Teixeira, Paulo; Cerski, Carlos Thadeu; Shivakumar, Pranavkumar; et al. "HIF-1alpha-pathway activation in cholangiocytes of patients with biliary atresia: An immunohistochemical/molecular exploratory study". Journal of Pediatric Surgery 57 9 (2022): http://dx.doi.org/10.1016/j.jpedsurg.2022.08.020.
    Open access • Published • 10.1016/j.jpedsurg.2022.08.020
  2. Nunes, David Ricardo da Conceição Marçal Alves; Breton, Michèle Claire; Monteiro, Cristina Sofia de Jesus; dos Santos, Jorge Luiz. "Drug Induced Liver Injury: Perspective of the Adverse Drug Reaction Reports to the Portuguese Pharmacovigilance System from 2010 to 2019". Healthcare 9 12 (2021): 1630. http://dx.doi.org/10.3390/healthcare9121630.
    Published • 10.3390/healthcare9121630
  3. Granato, Laís Moreira; Galdeano, Diogo Manzano; D’Alessandre, Nathália Da Roz; Breton, Michèle Claire; Machado, Marcos Antonio. "Callose synthase family genes plays an important role in the Citrus defense response to Candidatus Liberibacter asiaticus". European Journal of Plant Pathology 155 1 (2019): 25-38. http://dx.doi.org/10.1007/s10658-019-01747-6.
    10.1007/s10658-019-01747-6
  4. Dalio, R. J. D.; Maximo, H. J.; Oliveira, T. S.; Dias, R. O.; Breton, M. C.; Felizatti, H.; Machado, M.. "Phytophthora parasitica Effector PpRxLR2 Suppresses Nicotiana benthamiana Immunity". Molecular Plant-Microbe Interactions® 31 4 (2018): 481-493. http://dx.doi.org/10.1094/mpmi-07-17-0158-fi.
    10.1094/mpmi-07-17-0158-fi
  5. Máximo, Heros J.; Dalio, Ronaldo J. D.; Rodrigues, Carolina M.; Breton, Michèle C.; Machado, Marcos A.. "Reference genes for RT-qPCR analysis in Citrus and Poncirus infected by zoospores of Phytophthora parasitica". Tropical Plant Pathology 42 2 (2017): 76-85. http://dx.doi.org/10.1007/s40858-017-0134-8.
    10.1007/s40858-017-0134-8
  6. Galdeano, Diogo Manzano; Breton, Michèle Claire; Lopes, João Roberto Spotti; Falk, Bryce W.; Machado, Marcos Antonio. "Oral delivery of double-stranded RNAs induces mortality in nymphs and adults of the Asian citrus psyllid, Diaphorina citri". PLOS ONE 12 3 (2017): e0171847. http://dx.doi.org/10.1371/journal.pone.0171847.
    10.1371/journal.pone.0171847
  7. Ramos-González, Pedro; Chabi-Jesus, Camila; Guerra-Peraza, Orlene; Breton, Michèle; Arena, Gabriella; Nunes, Maria; Kitajima, Elliot; Machado, Marcos; Freitas-Astúa, Juliana. "Phylogenetic and Molecular Variability Studies Reveal a New Genetic Clade of Citrus leprosis virus C". Viruses 8 6 (2016): 153. http://dx.doi.org/10.3390/v8060153.
    10.3390/v8060153
  8. de Oliveira, L. A.; Breton, M. C.; Bastolla, F. M.; Camargo, S. d. S.; Margis, R.; Frazzon, J.; Pasquali, G.. "Reference Genes for the Normalization of Gene Expression in Eucalyptus Species". Plant and Cell Physiology 53 2 (2011): 405-422. http://dx.doi.org/10.1093/pcp/pcr187.
    10.1093/pcp/pcr187
  9. Pascon, Renata C.; Kitajima, João Paulo; Breton, Michèle C.; Assumpção, Laura; Greggio, Christian; Zanca, Almir S.; Okura, Vagner Katsumi; et al. "The Complete Nucleotide Sequence and Genomic Organization of Citrus Leprosis Associated Virus, Cytoplasmatic type (CiLV-C)". Virus Genes 32 3 (2006): 289-298. http://dx.doi.org/10.1007/s11262-005-6913-1.
    Published • 10.1007/s11262-005-6913-1
  10. CASAGRANDE, ELAINE CRISTINA; FARIAS, JOSÉ RENATO BOUÇAS; NEUMAIER, NORMAN; OYA, TETSUJI; PEDROSO, JÚLIO; MARTINS, POLYANA KELLY; BRETON, MICHÈLLE CLAIRE; NEPOMUCENO, ALEXANDRE LIMA. "Differential gene expression during water deficit in soybean". Revista Brasileira de Fisiologia Vegetal 13 2 (2001): 168-184. http://dx.doi.org/10.1590/s0103-31312001000200006.
    10.1590/s0103-31312001000200006
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09 - 2020/07 Drug Induced Liver Disease: Perspective of the Adverse Drug Reaction Reports to the Portuguese Pharmacovigilance Service from 2010 to 2019
Co-supervisor
 Mestrado integrado em Medicina (Master)
Faculdade de Ciências da Saúde UBI, Portugal
2019/09 - 2020/03 Um Jogo Sério de Diagnóstico Médico em Gastroenterologia
Co-supervisor
 Mestrado em Engenharia Informática UBI (Master)
Departamento de Informática UBI, Portugal
2010 - 2010 Comparative genomics in Eucalyptus grandis related to genes encoding transcription factors of the Dof family
Co-supervisor
 Biomedicina (Scientific initiation)
Centro de Biotecnologia da UFRGS, Brazil
2009/03 - 2009/12 Eucalyptus Genomics
Co-supervisor
 Farmácia (Scientific initiation)
Centro de Biotecnologia da UFRGS, Brazil

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2014/04/16 Expressão de genes das vias do jasmonato e etileno na resposta de plantas de citrus às bactérias Candidatus Liberibacter spp., causadoras do Huanlongbing.
(Thesis) Main arguer
 Luciane Fender Coerini (Master)
Universidade de São Paulo Escola Superior de Agricultura Luiz de Queiroz, Brazil
2011/12/05 Production of transgenic citrus plants targeting resistance to Huanglongbing (HLB)
(Thesis) Main arguer
 Amanda Reis (Other)
Centro Universitário Hermínio Ometto UNIARARAS, Brazil

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/02 - 2015/12 General Pathology Medicina Veterinária (Bachelor) Faculdade Anhanguera de Leme, Brazil
2014/02 - 2015/12 Genética Medicina Veterinária (Bachelor) Faculdade Anhanguera de Leme, Brazil
2014/02 - 2015/12 Microbiology and Immunology Enfermagem (Bachelor) Faculdade Anhanguera de Leme, Brazil

Mentoring / Tutoring

Topic Student name
2019/11 - 2020/01 Histology, Physiology and Anatomy of the Digestive System Curso de Medicina