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Hugo Celso Pinheiro. Publicou 24 artigos em revistas especializadas. Atua na(s) área(s) de Ciências Médicas e da Saúde.
Identification

Personal identification

Full name
Hugo Celso Pinheiro

Citation names

  • Pinheiro, Hugo

Author identifiers

Ciência ID
2D12-E171-81B5
ORCID iD
0000-0001-5329-8224

Telephones

Mobile phone
  • 934281902 (Professional)

Addresses

  • i3S/Ipatimup, Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2018/01/01 - 2023/03/31
Concluded
 Especialista em Medicina Interna (Título de especialista)
ULSTS, Portugal
2011/09/01 - 2016/07/22
Concluded
 Medicina (Mestrado integrado)
Universidade do Minho Escola de Medicina, Portugal
2008/01/01 - 2011/12/22
Concluded
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
 Approved with distinction
2005/09/01 - 2007/09/30
Concluded
 Genética Molecular (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
2000/09/01 - 2004/07/31
Concluded
 Biologia (Licenciatura)
Major in Ramo científico
Universidade do Porto Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2017/01/01 - Current Visiting Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/01/01 - 2016/12/31 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Other Careers

Category
Host institution 		Employer
2023/04/01 - Current Assistente (Médica) ULSTS, Portugal
2018/01/01 - 2023/03/31 Interno (Médica) Centro Hospitalar Tâmega e Sousa EPE, Portugal
2017/01/01 - 2017/12/31 Interno (Médica) Hospital da Senhora da Oliveira Guimarães, Portugal

Others

Category
Host institution 		Employer
2022/08/01 - Current Sócio-gerente Notável Outono Lda, Portugal
Projects

Contract

Designation Funders
2016/01/01 - Current A CDH1 founder-mutation in northern Portugal and its relevance for early diffuse gastric cancer diagnosis
.
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Universidade do Porto Instituto de Investigação e Inovação em Saúde
Ongoing
2018/07/01 - 2021/06/30 Definição da estrutura 3D da cromatina no locus CDH1 para identificar mecanismos associados à doença
PTDC/BTM-TEC/30164/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/05/01 - 2019/12/31 Tumour secreted factors in EMT/non-EMT cells for invasion and metastization
NORTE-01-0145-FEDER-000029
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 NORTE2020
Concluded
2016/01/01 - 2018/12/31 The Intronic Regulation Of The CDH1 Gene
IntCDH1
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Universidade do Porto Instituto de Patologia e Imunologia Molecular
Concluded
2016/01/01 - 2018/12/31 Defining The Contribution Of Mutations In CDH1 Non-Coding Regions And Other Known Susceptibility Genes To Hereditary Gastric Cancer
NSFC_2014
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Concluded
2013/01/01 - 2016/12/31 Using NGS To Uncover Structural And Regulatory Variation In Gastric Cancer
NGSGC_2013
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Concluded
2011/04/01 - 2014/09/30 Novos RNAs da E-caderina: o outro lado de um gene supressor de tumor
PTDC/SAU-GMG/110785/2009
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/08/01 - 2010/11/30 Role of novel regulatory mechanisms in the loss of E-cadherin expression
PTDC/SAU-GMG/72168/2006
PhD Student Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/07/01 - 2008/06/30 Identificação de mecanismos moleculares subjacentes ao desenvolvimento de cancro gástrico em famílias portadoras e não-portadoras de mutações germinativas da caderina-E
POCI/SAU-OBS/58111/2004
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Pinheiro H; Hugo Celso Pinheiro; Margarida Bela; Nuno Magalhães; Mari Mesquita. "Enfarte da Artéria de Percheron: Caso Clínico". Medicina Interna (2021): Vol. 28 N.º 2 (2021)-Vol. 28 N.º 2 (2021). https://revista.spmi.pt/index.php/rpmi/article/view/59.
    10.24950/CC/214/20/2/2021
  2. Pinheiro H; Matos Bela M; Leal AF; Nogueira L; Mesquita M. "Hidden Hunger: A Pellagra Case Report.". Cureus (2021): https://europepmc.org/articles/PMC8152714.
    10.7759/cureus.14682
  3. Pinheiro H; Ivone Duarte; A. Teixeira; Luisa Castro; Marina S; Carla Ribeiro; Jácome C; et al. "Burnout among Portuguese healthcare workers during the COVID-19 pandemic.". BMC public health (2020): https://europepmc.org/articles/PMC7720923.
    10.1186/s12889-020-09980-z
  4. Pinheiro, Hugo. "Redefinition of familial intestinal gastric cancer: clinical and genetic perspectives.". Journal of medical genetics (2020): https://doi.org/10.1136/jmedgenet-2019-106346.
    10.1136/jmedgenet-2019-106346
  5. Pinheiro, Hugo. "CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer.". BMC cancer (2019): https://europepmc.org/articles/PMC6332846.
    10.1186/s12885-019-5294-0
  6. Pinheiro, Hugo. "New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression.". Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2018): https://doi.org/10.1007/s10120-018-0836-8.
    10.1007/s10120-018-0836-8
  7. Pinheiro, Hugo. "Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing.". European journal of human genetics : EJHG (2017): https://europepmc.org/articles/PMC5643972.
    10.1038/ejhg.2017.138
  8. Vogelaar IP; Ligtenberg MJ; van der Post RS; de Voer RM; Kets CM; Jansen TJ; Jacobs L; et al. "Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect.". (2015): http://europepmc.org/abstract/med/26700889.
  9. Queirós P; Pinheiro H; Carvalho J; Oliveira P; Gullo I; Carneiro F; Almeida GM; Oliveira C. "KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity.". (2015): http://europepmc.org/abstract/med/26318594.
  10. van der Post RS; Vogelaar IP; Carneiro F; Guilford P; Huntsman D; Hoogerbrugge N; Caldas C; et al. "Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.". (2015): http://europepmc.org/abstract/med/25979631.
    10.1136/jmedgenet-2015-103094
  11. Hansford S; Kaurah P; Li-Chang H; Woo M; Senz J; Pinheiro H; Schrader KA; et al. "Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond.". (2015): http://europepmc.org/abstract/med/26182300.
    10.1001/jamaoncol.2014.168
  12. Oliveira C; Pinheiro H; Figueiredo J; Seruca R; Carneiro F. "Familial gastric cancer: genetic susceptibility, pathology, and implications for management.". (2015): http://europepmc.org/abstract/med/25638682.
    10.1016/S1470-2045(14)71016-2
  13. Pinheiro H; Oliveira P; Oliveira C. "Hereditary cancer risk assessment: challenges for the next-gen sequencing era.". (2015): http://europepmc.org/abstract/med/25853090.
    10.3389/fonc.2015.00062
  14. Pinheiro H; Oliveira C; Seruca R; Carneiro F. "Hereditary diffuse gastric cancer - pathophysiology and clinical management.". (2014): http://europepmc.org/abstract/med/25439071.
    10.1016/j.bpg.2014.09.007
  15. Gaston D; Hansford S; Oliveira C; Nightingale M; Pinheiro H; Macgillivray C; Kaurah P; et al. "Germline mutations in MAP3K6 are associated with familial gastric cancer.". (2014): http://europepmc.org/abstract/med/25340522.
    10.1371/journal.pgen.1004669
  16. Bordeira-Carriço R; Ferreira D; Mateus DD; Pinheiro H; Pêgo AP; Santos MA; Oliveira C. "Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA.". (2014): http://europepmc.org/abstract/med/24424122.
    10.1038/ejhg.2013.292
  17. Oliveira, C.; Pinheiro, H.; Figueiredo, J.; Seruca, R.; Carneiro, F.. "E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer". Progress in Molecular Biology and Translational Science 116 (2013): 337-359. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875262175&partnerID=MN8TOARS.
    10.1016/B978-0-12-394311-8.00015-7
  18. Carneiro, P.; Fernandes, M.S.; Figueiredo, J.; Caldeira, J.; Carvalho, J.; Pinheiro, H.; Leite, M.; et al. "E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions". FEBS Letters 586 18 (2012): 2981-2989. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864922992&partnerID=MN8TOARS.
    10.1016/j.febslet.2012.07.045
  19. Paredes, J.; Figueiredo, J.; Albergaria, A.; Oliveira, P.; Carvalho, J.; Ribeiro, A.S.; Caldeira, J.; et al. "Epithelial E- and P-cadherins: Role and clinical significance in cancer". Biochimica et Biophysica Acta - Reviews on Cancer 1826 2 (2012): 297-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861800037&partnerID=MN8TOARS.
    10.1016/j.bbcan.2012.05.002
  20. Pinheiro, H.; Carvalho, J.; Oliveira, P.; Ferreira, D.; Pinto, M.T.; Osoquot;rio, H.; Licastro, D.; et al. "Transcription initiation arising from E-cadherin/CDH1 intron2: A novel protein isoform that increases gastric cancer cell invasion and angiogenesis". Human Molecular Genetics 21 19 (2012): 4253-4269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866408689&partnerID=MN8TOARS.
    10.1093/hmg/dds248
  21. Corso, G.; Pedrazzani, C.; Pinheiro, H.; Fernandes, E.; Marrelli, D.; Rinnovati, A.; Pascale, V.; et al. "E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer". European Journal of Cancer 47 4 (2011): 631-639. http://www.scopus.com/inward/record.url?eid=2-s2.0-79851510776&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.10.011
  22. Corso, G.; Velho, S.; Paredes, J.; Pedrazzani, C.; Martins, D.; Milanezi, F.; Pascale, V.; et al. "Oncogenic mutations in gastric cancer with microsatellite instability". European Journal of Cancer 47 3 (2011): 443-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251593630&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.09.008
  23. Pinheiro, H.; Bordeira-Carriço, R.; Seixas, S.; Carvalho, J.; Senz, J.; Oliveira, P.; Inácio, P.; et al. "Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer". Human Molecular Genetics 19 5 (2010): 943-952. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950533734&partnerID=MN8TOARS.
    10.1093/hmg/ddp537
  24. Oliveira, C.; Senz, J.; Kaurah, P.; Pinheiro, H.; Sanges, R.; Haegert, A.; Corso, G.; et al. "Germline CDH1 deletions in hereditary diffuse gastric cancer families". Human Molecular Genetics 18 9 (2009): 1545-1555. http://www.scopus.com/inward/record.url?eid=2-s2.0-64549109715&partnerID=MN8TOARS.
    10.1093/hmg/ddp046
  25. Gonçalves, C.M.; Castro, M.A.A.; Henriques, T.; Oliveira, M.I.; Pinheiro, H.C.; Oliveira, C.; Sreenu, V.B.; et al. "Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily". Molecular Immunology 46 13 (2009): 2585-2596. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650569240&partnerID=MN8TOARS.
    10.1016/j.molimm.2009.05.006
  26. Oliveira, C.; Sousa, S.; Pinheiro, H.; Karam, R.; Bordeira-Carriço, R.; Senz, J.; Kaurah, P.; et al. "Quantification of Epigenetic and Genetic 2nd Hits in CDH1 During Hereditary Diffuse Gastric Cancer Syndrome Progression". Gastroenterology 136 7 (2009): 2137-2148. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149108352&partnerID=MN8TOARS.
    10.1053/j.gastro.2009.02.065
  27. Masciari, S.; Larsson, N.; Senz, J.; Boyd, N.; Kaurah, P.; Kandel, M.J.; Harris, L.N.; et al. "Germline E-cadherin mutations in familial lobular breast cancer". Journal of Medical Genetics 44 11 (2007): 726-731. http://www.scopus.com/inward/record.url?eid=2-s2.0-36348986039&partnerID=MN8TOARS.
    10.1136/jmg.2007.051268
Distinctions

Award

2016 Mhari Saito Scholarship
No Stomach For Cancer, United States