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I graduated in Biology (1990; Univ. Coimbra, Portugal), conducted my doctoral studies at the Charing Cross Hospital in London, UK, (1993-1997) and was awarded my doctorate in Molecular Genetics by the University of Lisbon in 1997. I then joined the lab of Charles ffrench-Constant, one of the foremost researchers in the field of myelinating glia, at the University of Cambridge, UK; as a post-doc (1997-2002), continued my research in glia cell biology first as a junior group leader at ETHZ, in Zurich, (2002-2008), and from 2009 as a Group leader and Principal Investigator at IBMC and i3S in Porto. Completed my “Habilitation” in Neuroscience at the Faculty of Medicine of the University of Porto, where I teach histology and embryology as an invited professor. In addition to expertise in glia biology, I have a broad background in mouse transgenics, transcriptomics and proteomics, and cell signalling. I have been PI and Co-PI on national and international projects financed by competitive funding, have experience in managing large program project grants intended for departmental support, have leadership experience acting as Neurobiology program coordinator (2015-2023), and vice-director of the i3S (2019-2023). I am a member of several boards and committees, including the editorial board of Glia (since 2019), the Executive Board of NetworkGlia (since 2024), the Scientific Committee of Fundação Bial (since 2016), the FENS History Committee (since 2022), the ISN Advanced School Committee (since 2023), and the external advisory board of the Achucarro Basque Centre for Neurosciences (since 2024), among others. I have also extensive experience in reviewing manuscripts for scientific journals, grants for national and international agencies and trusts; and in advising science and technology policies as a member and vice-president of the Health and Life Sciences Council of the Fundação para a Ciência e Tecnologia (FCT) (2013-2016).
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Identification

Personal identification

Full name
Joao Carlos Bettencourt de Medeiros relvas

Citation names

  • Relvas, JB
  • Relvas, Joao B
  • Relvas, João
  • Bettencourt Relvas, João

Author identifiers

Ciência ID
2D1A-908B-05A1
ORCID iD
0000-0001-7636-0924
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=ZK0Uvf0AAAAJ
Scopus Author Id
6602197103

Email addresses

  • jrelvas@ibmc.up.pt (Professional)

Addresses

  • Instituto de Biologia Molecular e Celular e Instituto de Investigação e Inovação em Saúde. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
French Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1) Upper intermediate (B2)
Education
Degree Classification
2023
Concluded
 Neurosciences (Título de Agregado)
Universidade do Porto Faculdade de Medicina, Portugal
1997/01
Concluded
 Molecular Genetics (Doctor of Philosophy)
Universidade de Lisboa, Portugal
 cum laude
1991 - 1993/05
Concluded
 Post-graduate student (Outros)
Instituto Gulbenkian de Ciência, Portugal
1985 - 1990
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra, Portugal
 16/20
Affiliation

Science

Category
Host institution 		Employer
2008/11 - Current Principal Investigator (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006 - 2008 Auxiliary Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/10 - 2002/10 Postdoc (Research) University of Cambridge, United Kingdom
1999/10 - 2001/10 Postdoc (Research) MRC Cambridge Centre for Brain Repair - University of Cambridge, United Kingdom
1997/10 - 1999/10 Postdoc (Research) Wellcome/CRC Institute for Developmental Biology and Cancer - University of Cambridge, United Kingdom
1993/06 - 1997 Research Assistant (Research) Charing Cross & Westminster Medical School (Imperial College of Medicine), United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2024 - Current Invited Full Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2019/01 - 2023 Invited Associate Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2015 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Ciências, Portugal
2011 - 2012 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2019/12 - 2023 Vice-Diretor Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01 - 2023 Coordinator - "Neurobiology and Neurological Disease Program" Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010/01 - 2023 Coordinator - Neuroscience Unit Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2018 - 2020 Coordinator- Porto Campus - Discoveries Centre for Regenerative and Personalised Medicine Discoveries Centre for Regenerative and Personalised Medicine, Portugal
Universidade do Porto, Portugal

Others

Category
Host institution 		Employer
2010 - Current Coordinator and Lecturer in "Módulo de Neurónios e Glia" of the PhD Program in Neurosciences Universidade do Porto Faculdade de Medicina, Portugal
2010 - 2022 Scientific Coordinator of the Histology and Electron Microscopy Service - IBMC and i3S, University of Porto Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010 - 2018 Coordinator and Lecturer of the yearly Glia Biology Course in the Graduate Program in Areas of Basic and Applied Biology Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2002/10 - 2008/10 Group Leader Eidgenössische Technische Hochschule Zürich, Switzerland
2002/10 - 2008/10 Lecturer of Cell and Molecular Biology Eidgenössische Technische Hochschule Zürich, Switzerland
2003 - 2008 Coordinator - Praktikum Neurobiologie Eidgenössische Technische Hochschule Zürich, Switzerland
2003 - 2006 Lecturer in the yearly advanced Course in Neuroscience Eidgenössische Technische Hochschule Zürich, Switzerland
Projects

Grant

Designation Funders
2023 - 2028 CARE-IN-HEALTH - CardiovascularREsolution of INflammation to promote HEALTH
HORIZON-HLTH-2022-STAYHLTH-02-01
Team Member
Ongoing
2021 - 2026 NCBIO: Unlocking Excellence in Research and Innovation in Neurobiology and Neurological Disorders at IBMC/i3S
WIDESPREAD-06-2020 ERA Chairs, project 951923
Team Member
Ongoing
2021 - 2025 LIFESAVER - Living Impact on Fetal Evolution: Shelter-Analyze-Validate-Empower
H2020-LC-GD-2020-3
Team Member
Ongoing
2022 - 2024 ATTENUATION - Advanced therapeutic approaches in addiction: targeting neuroinflammation
PTDC/SAU-TOX/0067/2021
Team Member
Ongoing
2022 - 2024 Msense - a miniaturized biosensor technology for personalized diagnostics and monitoring of multiple sclerosis
Prémio de Investigação Científica Alfredo da Silva
Team Member
Ongoing
2022 - 2023 Brain Sense - a biosensor for the diagnosis of multiple sclerosis
Amyris Innovation BIG Impact Award
Team Member
Concluded
2021 - 2023 Heart Failure-Chip: a miniaturized technology for self-monitoring of biomarkers in minimally or non-invasive body fluids
CaixaImpulse Validate
Team Member
Concluded
2021 - 2023 MUSIIC - Multiple Sclerosis Investigation and Innovation Chip
Team Member
Concluded
2017 - 2022 The Discoveries Centre for Regenerative and Precision Medicine
H2020-WIDESPREAD- TEAMMING; Project number 739572
Team Member
Concluded
2018 - 2021 PsychoGlia - Psychostimulant-induced neuroinflammation: new insight in the crosstalk between microglia, astrocytes and neurons
PTDC/SAU-TOX/30647/2017Y
Co-Principal Investigator (Co-PI)
Concluded
2016 - 2019 Porto Neurosciences and Neurologic Disease Research Initiative at I3S
NORTE-01-0145-FEDER-000008
Coordinator
Concluded
2017 - 2018 The Discoveries CTR - Setting Sails
NORTE-01-0246-FEDER-000022
Team Member
Concluded
2013 - 2017 Neuro-Enhancement Responsible Research and Innovation (NERRI)
FP7-SCIENCE-IN-SOCIETY-2012-1
Team Member
Concluded
2013 - 2015 Cell homeostasis, tissue organization and organism biology
Norte - 07-0124-FEDER-000003
Co-coordinator
Concluded
2007 - 2010 Role of integrin-linked-kinase and associated molecules in myelination and remyelination of the nervous system.
PTDC/BIA-BCM/69841/2006
Principal investigator
Concluded
2006 - 2009 The Function of RhoA in Myelinating Cells in Development and Disease
Co-Principal Investigator (Co-PI)
Concluded
2005 - 2009 Neural Stem Cells: An Integrated Approach to Basic Knowledge and Therapeutic Applications; National Centre Competence in Research (NCCR)
Team Member
Concluded
2005 - 2007 Functional Role of cdc42 in Oligodendrocyte and Schwann Cell Biology
0-20217-04
Principal investigator
2002 - 2005 Beta 1 Integrin in Oligodendrocyte Differentiation
0-85060-03
Principal investigator
Concluded

Contract

Designation Funders
2022/01/01 - 2024/12/31 Profilin1 at the crossroads between microglia, aging and neurodegeneration
PTDC/MED-NEU/1677/2021
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/06/30 Increasing Vitamin C uptake in Microglia for halting Alzheimer´s disease
EXPL/MED-NEU/0588/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/20 - 2021/10/19 Rac1 regulation of microglia homeostasis and pro-inflammatory polarisation (Role: PI; Funding: 234,000.00EU)
PTDC/MED-NEU/31318/2017
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 E-RISK (Role: participant; Funding Relvas lab: 33 250EU)
POCI-01-0145-FEDER-030356
Other
Ongoing
2016/07/01 - 2020/04/01 Mecanismos moleculares envolvidos no reconhecimento de células com perda da E-caderina
PTDC/BIM-ONC/0281/2014
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/06/30 Sensing dysfunctional E-cadherin cells in gastric epithelia
PTDC/BIM-ONC/0281/2014 -016586
Other
Concluded
2016/01/01 - 2018/12/31 Projecto ESSENCE (Delta) Portugal 2020 - SI I&DT - POCI-01-0247-FEDER-010887 (Role co-PI: 68.947EU)
POCI-01-0247-FEDER-010887
Concluded
2013/06/01 - 2015/09/30 Mutações da Caderina-E e Novos Interactores no Cancro (MECANIC). O papel da caderina-E mutada na interação integrina-matriz extracelular no cancro gástrico.
PTDC/BIM-ONC/0171/2012
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/05/01 - 2015/09/30 The ¿processosome¿: identification and characterization of proteins promoting oligodendrocyte process outgrowth, axon wrapping and (re) myelination of axons (Role PI, 114.062EU)
PTDC/SAU-NMC/119937/2010
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2015/04/30 Modulating Actin Dynamics during axonal regeneration: the role of adducin and profilin-1 (Co-PI. 35 000 CHF)
IRP Research Grant Contract P140
Concluded
2011/01/01 - 2014/06/30 Rho GTPases in the myelination and remyelination of the peripheral nervous system (Role PI: 185.011,00EU)
PTDC/BIA-BCM/112730/2009
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2014/06/30 Understanding the role of the axon/glia functional unit during developmental myelination and in remyelination (Role: PI 179.794EU)
PTDC/SAU-NEU/099007/2008
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2013/04/13 FP7-PEOPLE-2010-IEF - 276322 - OligProcessExtension (159.650EU)
276322
Concluded
2009/03/01 - 2011/08/11 AXOGLIA FP7 Marie Curie grant PIEF-GA-2009-236766 (165 000EU)
PIEF-GA-2009-236766
Concluded

Other

Designation Funders
2017 - 2023 EU Horizon 2020 -Teaming grant (Agreement: 641739) - The Discoveries Centre for Regenerative and Precision Medicine
641739
Other
Ongoing
2016/05/01 - 2019/12/30 Porto Neurosciences and Neurologic Disease Research Initiative at I3S
NORTE-01-0145-FEDER-000008
Principal investigator
Concluded
Outputs

Publications

Book chapter
  1. Melo, Pedro; S. Silveira, Mariana; Mendes-Pinto, Inês; Relvas, JB. Corresponding author: Relvas, JB. "MorphoMacro for in vivo and ex vivo quantitative morphometric analysis of microglia". In Radiation Oncology and Radiotherapy, 75-92. Elsevier, 2023.
    10.1016/bs.mcb.2022.08.003
  2. Salsinha, Ana Sofia; Socodato, Renato; Relvas, JB; Pintado, Manuela. "The pro- and antiinflammatory activity of fatty acids". In Bioactive Lipids, 51-75. Elsevier, 2023.
    10.1016/b978-0-12-824043-4.00002-6
  3. Vieira da Cunha, R.; Relvas, J.B.. ""Who's Afraid of the Big Bad Neuroscience? In Neuroscience's Impact on Our Notions of Self and Free Will". In The Human Sciences after the Decade of the Brain, 24-41. Elsevier, 2017.
    10.1016/b978-0-12-804205-2.00003-3
  4. Socodato, Renato; Portugal, Camila C.; Sampaio, Paula; Relvas, João B.. "Studying subcellular signaling events in living microglial cells using fluorescence resonance energy transfer-based nanosensors". In Fluorescence Imaging and Biological Quantification, 165-179. CRC Press, 2017.
    10.1201/9781315121017-10
  5. Joana Paes de Faria; Filipa Neto; Nuno Gonçalo Dias; João Bettencourt Relvas. "Mielina e Patologias Associadas (Capítulo 5)". In Neurociências. Lidel, 2017.
  6. Montani, L.; Bausch-Fluck, D.; Domingues, A.F.; Wollscheid, B.; Relvas, J.B.. "Identification of new interacting partners for atypical Rho GTPases: A SILAC-based approach". 2012.
    10.1007/978-1-61779-442-1_20
  7. Teresa Summavielle; João Bettencourt Relvas. "Células do Sistema Nervoso". In Biologia Celular e Molecular (5ª Edição). Lidel, 2012.
  8. Bruce, C.C.; Franklin, R.J.M.; Relvas, J.B.. "Remyelination of the central nervous system". 2007.
    10.1007/978-0-387-70830-0_19
Journal article
  1. Costa-Pinto, Sara; Gonçalves-Ribeiro, Joana; Tedim-Moreira, Joana; Socodato, Renato; Relvas, João B.; Sebastião, Ana M.; Vaz, Sandra H.. "Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice". Neurobiology of Disease 193 (2024): 106435. http://dx.doi.org/10.1016/j.nbd.2024.106435.
    10.1016/j.nbd.2024.106435
  2. Socodato, Renato; Relvas, João B.. "A Cytoskeleton Symphony: Actin and Microtubules in Microglia Dynamics and Aging". Progress in Neurobiology (2024): 102586. http://dx.doi.org/10.1016/j.pneurobio.2024.102586.
    10.1016/j.pneurobio.2024.102586
  3. Socodato, Renato; Almeida, Tiago O.; Portugal, Camila C.; Santos, Evelyn C.S.; Tedim-Moreira, Joana; Galvão-Ferreira, João; Canedo, Teresa; et al. Corresponding author: Relvas, JB. "Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance". Cell Reports 42 12 (2023): 113447. http://dx.doi.org/10.1016/j.celrep.2023.113447.
    10.1016/j.celrep.2023.113447
  4. Socodato, Renato; Rodrigues-Santos, Artur; Tedim-Moreira, Joana; Almeida, Tiago O.; Canedo, Teresa; Portugal, Camila C.; Relvas, JB. Corresponding author: Relvas, JB. "RhoA balances microglial reactivity and survival during neuroinflammation". Cell Death & Disease 14 10 (2023): http://dx.doi.org/10.1038/s41419-023-06217-w.
    10.1038/s41419-023-06217-w
  5. Rocha, Daniela N.; Carvalho, Eva D.; Pires, Liliana R.; Gardin, Chiara; Zanolla, Ilaria; Szewczyk, Piotr K.; Machado, Cláudia; et al. "It takes two to remyelinate: A bioengineered platform to study astrocyte-oligodendrocyte crosstalk and potential therapeutic targets in remyelination". Biomaterials Advances 151 (2023): 213429. http://dx.doi.org/10.1016/j.bioadv.2023.213429.
    10.1016/j.bioadv.2023.213429
  6. Seixas, Ana I.; Morais, Miguel R.G.; Brakebusch, Cord; Relvas, JB. Corresponding author: Relvas, JB. "A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination". Progress in Neurobiology 227 (2023): 102481. http://dx.doi.org/10.1016/j.pneurobio.2023.102481.
    10.1016/j.pneurobio.2023.102481
  7. Salsinha, A.S.; Socodato, R.; Rodrigues, A.; Vale-Silva, R.; Relvas, JB; Pintado, M.; Rodríguez-Alcalá, L.M.. "Potential of omega-3 and conjugated fatty acids to control microglia inflammatory imbalance elicited by obesogenic nutrients". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1868 7 (2023): 159331. http://dx.doi.org/10.1016/j.bbalip.2023.159331.
    10.1016/j.bbalip.2023.159331
  8. Sepúlveda, M. Rosario; Relvas, João B.; Peri, Francesca; Neubrand, Veronika E.. "Editorial: Cell biology of microglia". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1210124.
    10.3389/fncel.2023.1210124
  9. Báo, Sônia Nair; Machado, Manuela; Da Silva, Ana Luisa; Melo, Adma; Cunha, Sara; Sousa, Sérgio S.; Malheiro, Ana Rita; et al. "Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System". Molecules 28 3 (2023): 1219. http://dx.doi.org/10.3390/molecules28031219.
    10.3390/molecules28031219
  10. Paes de Faria, Joana; Vale-Silva, Raquel S.; Fässler, Reinhard; Werner, Hauke B.; Relvas, JB. Corresponding author: Relvas, JB. "Pinch2 regulates myelination in the mouse central nervous system". Development 149 13 (2022): http://dx.doi.org/10.1242/dev.200597.
    10.1242/dev.200597
  11. Melo, Pedro; Socodato, Renato; Silveira, Mariana S.; Neves, Miguel António Dias; Relvas, JB; Mendes Pinto, Inês. "Mechanical actuators in microglia dynamics and function". European Journal of Cell Biology 101 3 (2022): 151247. http://dx.doi.org/10.1016/j.ejcb.2022.151247.
    10.1016/j.ejcb.2022.151247
  12. Rocha, Daniela Nogueira; Carvalho, Eva Daniela; Relvas, JB; Oliveira, Maria José; Pêgo, Ana Paula. "Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology". Frontiers in Neuroscience 16 (2022): http://dx.doi.org/10.3389/fnins.2022.861613.
    10.3389/fnins.2022.861613
  13. Plácido, Alexandra; do Pais do Amaral, Constança; Teixeira, Cátia; Nogueira, Ariane; Brango-Vanegas, José; Alves Barbosa, Eder; C. Moreira, Daniel; et al. "Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from Pelophylax perezi". Journal of Cellular and Molecular Medicine 26 10 (2022): 2793-2807. http://dx.doi.org/10.1111/jcmm.17292.
    10.1111/jcmm.17292
  14. Campos, Ana Bela; Duarte-Silva, Sara; Fernandes, Bruno; das Neves, Sofia Pereira; Marques, Fernanda; Teixeira-Castro, Andreia; Neves-Carvalho, Andreia; et al. "Profiling Microglia in a Mouse Model of Machado-Joseph Disease". Biomedicines 10 2 (2022): 237. http://dx.doi.org/10.3390/biomedicines10020237.
    10.3390/biomedicines10020237
  15. Bravo, Joana; Ribeiro, Inês; Terceiro, Ana Filipa; Andrade, Elva B.; Portugal, Camila Cabral; Lopes, Igor M.; Azevedo, Maria M.; et al. "Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity". Cells 11 3 (2022): 355. http://dx.doi.org/10.3390/cells11030355.
    10.3390/cells11030355
  16. Pedro Neves Melo; Mariana Silveira; Inês Mendes Pinto; João Bettencourt Relvas. "Morphofunctional programming of microglia requires distinct roles of type II myosins". Glia (2021): https://doi.org/10.1002/glia.24067.
    10.1002/glia.24067
  17. Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Silva-Carvalho, Amandda É.; Cabral, Wanessa F.; et al. "The peptide secreted at the water to land transition in a model amphibian has antioxidant effects". Proceedings of the Royal Society B: Biological Sciences 288 1962 (2021): http://dx.doi.org/10.1098/rspb.2021.1531.
    10.1098/rspb.2021.1531
  18. Portugal, Camila C.; Almeida, Tiago O.; Socodato, Renato; Relvas, João B.. "Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases". The FEBS Journal (2021): http://dx.doi.org/10.1111/febs.16197.
    10.1111/febs.16197
  19. Canedo, Teresa; Portugal, Camila Cabral; Socodato, Renato; Almeida, Tiago Oliveira; Terceiro, Ana Filipa; Bravo, Joana; Silva, Ana Isabel; et al. "Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine". Neuropsychopharmacology 46 13 (2021): 2358-2370. http://dx.doi.org/10.1038/s41386-021-01139-7.
    10.1038/s41386-021-01139-7
  20. Salsinha, Ana Sofia; Rodríguez-Alcalá, Luis Miguel; Relvas, JB; Pintado, Manuela Estevez. "Fatty acids role on obesity induced hypothalamus inflammation: From problem to solution - A review". Trends in Food Science & Technology 112 (2021): 592-607. http://dx.doi.org/10.1016/j.tifs.2021.03.042.
    10.1016/j.tifs.2021.03.042
  21. Tavares, Lígia; Grácio, Patrícia; Ramos, Raquel; Traquete, Rui; Relvas, João B.; Pereira, Paulo S.. "The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye". Developmental Biology 473 (2021): 90-96. http://dx.doi.org/10.1016/j.ydbio.2021.02.002.
    10.1016/j.ydbio.2021.02.002
  22. Portugal, Camila C.; da Encarnação, Thaísa G.; Sagrillo, Mayara A.; Pereira, Mariana R.; Relvas, João B.; Socodato, Renato; Paes-de-Carvalho, Roberto. "Activation of adenosine A3 receptors regulates vitamin C transport and redox balance in neurons". Free Radical Biology and Medicine 163 (2021): 43-55. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.039.
    10.1016/j.freeradbiomed.2020.11.039
  23. Socodato, Renato; Melo, Pedro; Ferraz-Nogueira, José P.; Portugal, Camila C.; Relvas, João B.. "A Protocol for FRET-Based Live-Cell Imaging in Microglia". STAR Protocols 1 3 (2020): 100147. http://dx.doi.org/10.1016/j.xpro.2020.100147.
    10.1016/j.xpro.2020.100147
  24. Vasconcelos, Andreanne G.; Valim, Martina O.; Amorim, Adriany G.N.; do Amaral, Constança Pais; de Almeida, Miguel Peixoto; Borges, Tatiana K.S.; Socodato, Renato; et al. "Cytotoxic activity of poly-¿-caprolactone lipid-core nanocapsules loaded with lycopene-rich extract from red guava (Psidium guajava L.) on breast cancer cells". Food Research International 136 (2020): 109548. http://dx.doi.org/10.1016/j.foodres.2020.109548.
    10.1016/j.foodres.2020.109548
  25. Relvas, JB; Renato Socodato; Joana F. Henriques; Camila C. Portugal; Tiago Almeida; Joana Tedim-Moreira; Renata Alves; et al. "Alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior.". Science Signaling (2020):
    Accepted
  26. Renato Socodato; Camila C. Portugal; Teresa Canedo; Artur Rodrigues; Tiago Almeida; Joana F. Henriques; Sandra Vaz; et al. "Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration". Cell Reports (2020):
    In press
  27. Plácido, Alexandra; Bueno, João; Barbosa, Eder A.; Moreira, Daniel C.; Dias, Jhones do Nascimento; Cabral, Wanessa Felix; Albuquerque, Patrícia; et al. "The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra)". Biomolecules 10 4 (2020): 512. http://dx.doi.org/10.3390/biom10040512.
    10.3390/biom10040512
  28. Cancelarich, Natalia L.; Wilke, Natalia; Fanani, Mari´a L.; Moreira, Daniel C.; Pérez, Luis O.; Alves Barbosa, Eder; Plácido, Alexandra; et al. "Somuncurins: Bioactive Peptides from the Skin of the Endangered Endemic Patagonian Frog Pleurodema somuncurense". Journal of Natural Products 83 4 (2020): 972-984. http://dx.doi.org/10.1021/acs.jnatprod.9b00906.
    10.1021/acs.jnatprod.9b00906
  29. Sousa, Nayara A.; Oliveira, Guilherme A. L.; de Oliveira, Ana Patrícia; Lopes, André Luís F.; Iles, Bruno; Nogueira, Kerolayne M.; Araújo, Thiago S. L.; et al. "Novel Ocellatin Peptides Mitigate LPS-induced ROS Formation and NF-kB Activation in Microglia and Hippocampal Neurons". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-59665-1.
    10.1038/s41598-020-59665-1
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  87. Leone, D.P.; Relvas, J.B.; Campos, L.S.; Hemmi, S.; Brakebusch, C.; Fässler, R.; Ffrench-Constant, C.; Suter, U.. "Regulation of neural progenitor proliferation and survival by ß1 integrins". Journal of Cell Science 118 12 (2005): 2589-2599. http://www.scopus.com/inward/record.url?eid=2-s2.0-21644437452&partnerID=MN8TOARS.
    10.1242/jcs.02396
  88. Campos, L.S.; Leone, D.P.; Relvas, J.B.; Brakebusch, C.; Fässler, R.; Suter, U.; Ffrench-Constant, C.. "ß1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance". Development 131 14 (2004): 3433-3444. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243144135&partnerID=MN8TOARS.
    10.1242/dev.01199
  89. Colognato, H.; Baron, W.; Avellana-Adalid, V.; Relvas, J.B.; Baron-Van Evercooren, A.; Georges-Labouesse, E.; ffrench-Constant, C.. "CNS integrins switch growth factor signalling to promote target-dependent survival". Nature Cell Biology 4 11 (2002): 833-841. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036850183&partnerID=MN8TOARS.
    10.1038/ncb865
  90. Vogelezang, M.G.; Liu, Z.; Relvas, J.B.; Raivich, G.; Scherer, S.S.; Ffrench-Constant, C.. "a4 integrin is expressed during peripheral nerve regeneration and enhances neurite outgrowth". Journal of Neuroscience 21 17 (2001): 6732-6744. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035437867&partnerID=MN8TOARS.
  91. Prestoz, L.; Relvas, J.B.; Hopkins, K.; Patel, S.; Sowinski, P.; Price, J.; Ffrench-Constant, C.. "Association between integrin-dependent migration capacity of neural stem cells in vitro and anatomical repair following transplantation". Molecular and Cellular Neuroscience 18 5 (2001): 473-484. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035652117&partnerID=MN8TOARS.
    10.1006/mcne.2001.1037
  92. Relvas, J.B.; Setzu, A.; Baron, W.; Buttery, P.C.; LaFlamme, S.E.; Franklin, R.J.M.; Ffrench-Constant, C.. "Expression of dominant-negative and chimeric subunits reveals an essential role for ß1 integrin during myelination". Current Biology 11 13 (2001): 1039-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035838420&partnerID=MN8TOARS.
    10.1016/S0960-9822(01)00292-5
  93. Milner, R.; Relvas, J.B.; Fawcett, J.; Ffrench-Constant, C.. "Developmental regulation of av integrins produces functional changes in astrocyte behavior". Molecular and Cellular Neuroscience 18 1 (2001): 108-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034743196&partnerID=MN8TOARS.
    10.1006/mcne.2001.1003
  94. Jacques, T.S.; Relvas, J.B.; Nishimura, S.; Pytela, R.; Edwards, G.M.; Streuli, C.H.; Ffrench-Constant, C.. "Neural precursor cell chain migration and division are regulated through different ß1 integrins". Development 125 16 (1998): 3167-3177. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031708971&partnerID=MN8TOARS.
  95. Clark, K.M.; Watt, D.J.; Lightowlers, R.N.; Johnson, M.A.; Relvas, J.B.; Taanman, J.-W.; Turnbull, D.M.. "SCID mice containing muscle with human mitochondrial DNA mutations. An animal model for mitochondrial DNA defects". Journal of Clinical Investigation 102 12 (1998): 2090-2095. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032535088&partnerID=MN8TOARS.
    10.1172/JCI944
  96. Jen, L.S.; Hart, A.I.; Jen, A.; Relvas, J.B.; Gentleman, S.M.; Garey, L.J.; Patel, A.J.. "Alzheimer's peptide kills cells of retina in vivo". Nature 392 6672 (1998): 140-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032510580&partnerID=MN8TOARS.
    10.1038/32327
  97. Relvas, JB; Aldridge, H; Wells, KE; Wells, DJ; Watt, DJ. "Exogenous genes are expressed in mdx muscle fibres following the implantation of primary mouse skin cells". Basic and Applied Myology 7 3-4 (1997): 211-219.
  98. Gibson, A.J.; Karasinski, J.; Relvas, J.; Moss, J.; Sherratt, T.G.; Strong, P.N.; Watt, D.J.. "Dermal fibroblasts convert to a myogenic lineage in mdx mouse muscle". Journal of Cell Science 108 1 (1995): 207-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028872320&partnerID=MN8TOARS.
Preprint
  1. Socodato, Renato; Relvas, JB. Corresponding author: Relvas, JB. "Actin And Microtubules: A Tale of Two Cytoskeletons in Microglial Function". 2023. http://dx.doi.org/10.2139/ssrn.4646303.
    10.2139/ssrn.4646303

Intellectual property

Provisional application for patent
  1. 2023. "A miniaturized ultrasensitive point of care biosensor for minimally invasive quantitative molecular profiling of neurodegeneration".

Other

Other output
  1. Profiling interdisciplinarity in higher education: an ecological approach. Working Papers in Higher Education Studies, Volume 3, 121-145. 2018. Ribeiro, F. A.; Relvas, J.B..
  2. Manifesto pela Interdisciplinaridade - Por uma educação transformadora. Cadernos de Literatura Comparada N.º 37 - 12/ 2017 | 229-250.. 2017. Ribeiro, F. M.; Relvas, J.B..
Spin-off company
  1. 2018. Bioprospectum Lda.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023 Departing from a neurocentric-only view of the nervous system: the emerging roles of glia
(Faro, Portugal)
2023 Regulation of glia homeostasis by RhoGTPases comes with sex differences
Centre for Integrative Physiology and Molecular Medicine (Homburg, Germany)
2023 Regulation of Glial homeostasis by RhoGTPase signaling
(Albufeira, Portugal)
2023 Regulation of Glial Homeostasis: Implications for Neurological Disease
Biotech Research and Innovation Centre (BRIC) (Copenhagen, Denmark)
2022 Microglia goes to trial: from bystanders to presumed culprits X Simpósio de Neurociências da UFF/ V Simpósio de Neurociências a UFF-Fiocruz
(Niterói, Brazil)
2021 Glia homeostasis at i3S
(Marvão, Portugal)
2021 Glia Homeostasis
(Brazil)
2021 A revolução glial – Repensar o cérebro
University of Brasília (Brasilia, Brazil)
2021 A microglia view of neuronal homeostasis
CNC, University of Coimbra (Coimbra, Portugal)
2020 And the end of all our exploring will be to arrive where we started EIT Health Ageing PhD School - Advanced Imaging Methods in Neuroscience
(Portugal)
2020 A hora da actina: do Rio de Janeiro ao Porto
(Brazil)
2019 RhoGTPase regulation of redox homeostasis in microglia
(Ferrara, Italy)
2019 RhoGTPase signaling controls glia homeostasis
(Lisbon, Portugal)
2019 Microglia function regulation by RhoGTPases XLV Sociedade Portuguesa de Imunologia
(Coimbra, Portugal)
2018 Molecular mechanisms regulating glial homeostasis
(Lisbon, Portugal)
2018 Mechanisms of glia homeostasis: implications for neurological disease
ITQB/IBET, Universidade Nova de Lisboa (Lisbon, Portugal)
2017 Rho GTPase regulation of glia homeostasis
(Edinburgh, United Kingdom)
2017 Regulation of glial homeostasis
(Braga, Portugal)
2017 Microglia goes to trial: from bystanders to presumed culprits
Instituto de investigação e Inovação em Saúde (i3S) (Porto, Portugal)
2017 Microglia goes to trial: from bystanders to presumed culprits Ciência falada ICVS - Seminar series
ICVS, University of Minho (Braga, Portugal)
2017 Regulation of Glial homeostasis in the adult brain
CEDOC, New University of Lisbon (Lisbon, Portugal)
2016 Microglia homeostasis
(Coimbra, Portugal)
2016 RhoA regulation of microglial homeostasis
Max Planck Institute for Molecular Medicine (Munich, Germany)
2016 RhoA regulation of microglial homeostasis
Departamento de Ciências Médicas, Instituto de Biomedicina - iBIMED, University of Aveiro (Aveiro, Portugal)
2015 Rhocking glia and other tunes
(Coimbra, Portugal)
2015 RhoGTPase function in glia homeostasis
Centre for Research in Molecular Medicine and Chronic Diseases (São Tiago de Compostela, Spain)
2015 RhoGTPase function in glia homeostasis
Faculty of Medicine Universidad Autónoma Madrid (Madrid, Spain)
2015 RhoGTPases signaling regulation of glial homeostasis
INL-International Iberian Nanotechnology Laboratory (Braga, Portugal)
2014 The leading edge of myelination
Federal University of Bahia (Bahia, Brazil)
2013 The leading edge of myelination Centre for Regenerative Medicine Seminar Series SCMR
University of Edinburgh (Edinburgh, United Kingdom)
2012 PINCH signaling in myelination
(Baltimore, United States)
2012 Regulation of myelination by cytoskeleton-associated proteins
(Lisbon, Portugal)
2011 Two PINCHs-two functions. Regulating radial sorting and autocrine Schwann cell survival in PNS development
(Crete, Greece)
2011 The integrin-PINCH-parvin complex in nervous system myelination
(Athens, Greece)
2011 Dois PINCH, duas funções. Relevância para o sistema nervoso periférico
(Brazil)
2011 Myelination of the Peripheral Nervous System I International Conference on Neurophysiology
(Vila Nova de Gaia, Portugal)
2011 Two PINCHs-two functions: insights in Schwann Cell biology
(Lisbon, Portugal)
2011 Rholling the wrap: insights in Schwann cell biology
Biotech Research and Innovation Centre (BRIC) (Copenhagen, Denmark)
2011 Two PINCHs-two functions: Regulating radials sorting and autocrine Schwann cell survival in PNS development
Institute for Cell Biology, Swiss Federal Institute of Technology Zurich (ETHZ) (Zurich, Switzerland)
2010 Extracellular regulation of myelination: role of the IPP complex of proteins
(Coimbra, Portugal)
2010 Extracellular regulation of myelination
(Faro, Portugal)
2010 Extracellular regulation of myelination
(Porto, Portugal)
2009 Key roles for the IPP complex of proteins in myelination
British Neuroscience Association Seminar Series at Edinburgh (Edinburgh, United Kingdom)
2009 Extracellular regulation of myelination
Instituto de Medicina Molecular (IMM), University of Lisbon (Lisbon, Portugal)
2009 Extracellular regulation of myelination
Research Institute for Medicines and Pharmaceutical Sciences, University of Lisbon (Lisbon, Portugal)
2009 Extracellular regulation of myelinating Glia
ICVS, University of Minho (Braga, Portugal)
2008 Extracellular regulation of myelination
(Brazil)
2008 Regulation of PNS myelination by integrin-linked-kinase (ILK) and associated molecules
(Italy)
2008 Differentiation of oligodendrocytes in demyelinating diseases
(Geneve, Switzerland)
2008 Extracelullar regulation of myelination
(Porto, Portugal)
2007 Extracellular signaling and the regulation of PNS and CNS myelination
(Rio de Janeiro, Brazil)
2007 Neural progenitor differentiation: oligodendrocytes and myelination
(Coimbra, Portugal)
2007 Remyelination as a regeneration paradigm
(Ofir, Portugal)
2007 Integrin signaling and downstream effectors in myelination
Department of Materials, ETHZ (Zurich, Switzerland)
2007 The naked axon says: Catch me if you can!
Institute of Anatomy, University of Zurich (Zurich, Switzerland)
2007 FILK it, PINCH it, and Rho’ ll it: it's getting on my nerves!
Department of Anatomy, University of Basel (Basel, Switzerland)
2007 Studies on the extracellular regulation of myelination and remyelination
INEB, University of Porto (Porto, Portugal)
2006 Neural Stem Cells differentiation and repair
(Porto, Portugal)
2006 Rho GTPases in myelination
University of Cambridge (Cambridge, United Kingdom)
2006 Myelination - the nerve wraps and the rac Rhols Developmental Biology Seminar Series
The Gurdon Institute, University of Cambridge (Cambridge, United Kingdom)
2005 Rho GTPase function in myelination
(Zurich, Switzerland)
2005 Integrin signaling and myelination
CNC, University of Coimbra (Coimbra, Portugal)
2004 Role of the small Rho GTPases cdc42 and rac1 in oligodendrocyte biology
University of Tu¨bingen (Germany)
2004 Rho GTPase cdc42 and CNS myelination
Max-Planck-Institute for Biochemistry (Munich, Germany)
2004 Role of the RhoGTPases cdc42 and rac1 in oligodendrocyte biology
Max Planck Institute for Experimental Medicine (Gottingen, Germany)
2000 Integrins, oligodendrocytes and myelin membrane formation
Department of Neuropathology and Clinical Neuroscience, Imperial College Science and Medicine, University of London (London, United Kingdom)
1997 Conversion of skin fibroblasts to the myogenic lineage
Department of Anatomy Seminars, Charing Cross and Westminster Medical School (London, United Kingdom)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Impact of mushroom nutrition on gut microbiota modulation and association with neuroprotective capacity
Co-supervisor
2022 - Current Utilization of Omega 3 and Conjugated Fatty Acids to Develop New Antiobesity Strategies
Co-supervisor
2022 - Current Nonconventional Biomarkers in Multiple Sclerosis
Co-supervisor
2021 - Current Role of cdc42 in microglia function
Supervisor
2021 - Current Psychostimulant-induced neuroinflammation: the role of RhoGTPases in microglia
Co-supervisor
2020/01 - Current Regulation of Myelination by PINCH-Mediated Signaling
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01 - Current Unveilling the Roles of Small Rho GTPase Rac1 in Microglia Homeostasis and Activation During Neuroinflammation
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 - 2023 Characterisation of microglial response to environmental enrichment: the role of the RhoGTPase Rac1
Co-supervisor
2022 - 2023 Modulating ascorbate transport in microglia to target learning and memory deficits in Parkinson´s disease
Co-supervisor
2018 - 2023 Psychostimulants and neuroinflammation: finding critical players in the crosstalk between glial cells and neurons
Co-supervisor
2021 - 2022 Impact of neuronal activity on redox balance of neurons and glia
Co-supervisor
2017/09 - 2022 Mechanical principles driving microglia activation
Supervisor
 GABBA
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - 2021 More bit than bio: communicating and discussing whole Brain Emulation, Mind Uploading & Superintellingence using thought experiments
Supervisor
2019 - 2020 Alcohol intake triggers aberrant synaptic pruning and synapse loss
Supervisor
2019 - 2019 Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration
Co-supervisor
2019 - 2019 Two birds, one frog: evaluating the therapeutic potential of amphibian ocellatin-PT4 and -PT9 peptides for application in leishmaniasis and neuroinflammation-related diseases
Co-supervisor
2018 - 2019 Deciphering the role of RhoA in microglia inflammation
Co-supervisor
2018 - 2019 Control of microglia morphodynamics by the small RhoGTPase RhoA
Supervisor
2018 - 2018/10 Mechanisms of actin cytoskeletal dynamics in oligodendrocyte biology and myelin formation
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018 Birds of a different feather: Pinch1 and Pinch2-mediated signaling in CNS myelination
Co-supervisor
2017 - 2018 Rac1 Regulation of microglia during homeostasis and neuroinflammation
Co-supervisor
2017 - 2018 Regulation of developmental myelination in the peripheral nervous system by Rho signaling
Co-supervisor
2017 - 2018 Impact of SVCT2 modulation in neurodegeneration: a fly-based approach
Co-supervisor
2016 - 2016 Aggregation-Promoting Factors in Neurodegenerative Diseases
Co-supervisor
2015 - 2015 Towards the development of new therapeutic strategies for demyelinating diseases: a microengineering platform for the screening of therapeutical targets promoting remyelination
Co-supervisor
2015 - 2015 The oligodendrocyte processosome: novel regulators of differentiation and myelination
Supervisor
2013 - 2013 Identification and validation of new potential targets for neuroprotection following experimental demyelination
Supervisor
2012 - 2012/04 Functional Characterization of Frabin, a Protein mutant in Charcot-Marie-Tooth Disease
Co-supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland
2012 - 2012/04 Analysis of Rho GTPase signalling in peripheral nervous system development: Proteomic and functional approaches
Co-supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland
2012 - 2012 Functional Characterization of Frabin, a Protein mutant in Charcot-Marie-Tooth Disease
Co-supervisor
2012 - 2012 Analysis of Rho GTPase signaling in peripheral nervous system development: Proteomic and functional approaches
Co-supervisor
2012 - 2012 Identifying neuromuscular abnormalities in RhoBTB3 deficient mice, using SHIRPA
Supervisor
2010 - 2010/10 Analysis of the role of PINCH in system nervous myelination
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 - 2010 Rnd3/RhoE interactome
Supervisor
2010 - 2010 Mielinização e remielinização do Sistema Nervoso Periférico: funções das proteínas gelsolina e profilina 1.
Supervisor
2009 - 2009 Role of the small Rho GTPase rhoA in Neural stem and progenitor cells
Supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland
2008 - 2008/12 Integrin-linked-kinase function in nervous system myelination
Supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland
2008 - 2008/10 Analysis of the role of TGFB signaling in central nervous myelination and remyelination
Supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland

Universidade de Coimbra, Portugal
2008 - 2008 Analysis of the role of the small GTPase RhoA in peripheral nervous system myelination and remyelination
Supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland
2006 - 2006 Studies on vertebrate nervous system myelination
Supervisor
 Diss., Naturwissenschaften (PhD)
Eidgenössische Technische Hochschule Zürich, Switzerland
2006 - 2006 Analysis of the role of integrin beta 1 and the Rho GTPases cdc42 and rac1 in central nervous myelination
Supervisor
Eidgenössische Technische Hochschule Zürich, Switzerland

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 XV ISN Biennal Meeting on Myelin (2023/08/02 - 2023/08/04)
Meeting (Member of the Organising Committee)
2023 - 2023 Joint International Society of Neurochemistry-European Society of Neurochemistry (ISN-ESN) Meeting (2023/07/30 - 2023/08/10)
Meeting (Member of the Organising Committee)
2023 - 2023 XVI European Glial meeting, Glial Cells in Health and Disease (2023/07/08 - 2023/07/11)
Meeting (Member of the Organising Committee)
2021 - 2021 XV European Glial meeting, Glial Cells in Health and Disease (2021/07/07 - 2021/07/10)
Meeting (Member of the Organising Committee)
2019 - 2019 XIV European Glial meeting, Glial Cells in Health and Disease (2019/07/10 - 2019/07/13)
Meeting (Member of the Organising Committee)
2019 - 2019 Meeting of the Portuguese Society for Neuroscience (2019/05/30 - 2019/06/01)
Meeting (Member of the Scientific Committee)
 Sociedade Portuguesa de Neurociências, Portugal
2019 - 2019 Discoveries Forum on Regenerative and Precision Medicine (2019/09/25 - 2019/09/27)
Meeting (Other)
2019 - 2019 Satellite Meeting – SPN Meeting 2019 – IV Symposium – Glia Diversity in Modulation and Neurodegeneration (2019/05/29 - 2019/05/29)
Meeting (Member of the Organising Committee)
2018 - 2018 III Symposium Portuguese Glial Meeting (2018/05/18 - 2018/05/18)
Meeting (Member of the Organising Committee)
2017 - 2017 XV Meeting of the Portuguese Society for Neuroscience (2017/05/25 - 2017/05/26)
Meeting (Member of the Scientific Committee)
2015 - 2015 XIV Meeting of the Portuguese Society for Neuroscience (SPN2015) (2015/06/04 - 2015/06/05)
Meeting (Member of the Organising Committee)
2013 - 2013 XIII Meeting of the Portuguese Society for Neuroscience (2013/05/30 - 2013/06/01)
Meeting (Member of the Scientific Committee)
2010 - 2010 XVII Congresso Nacional de Bioquímica (2010/12/15 - 2010/12/17)
Congress (Member of the Scientific Committee)
2010 - 2010 Harvard Medical School Workshop on Animal Models for Neuroscience (2010/10/18 - 2010/10/22)
Workshop (Co-organisor)
2007 - 2007 2nd International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy. (2007/04/27 - 2007/04/28)
Meeting (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - 2023 Session Chair - 2nd Symposium on Alzheimer´s Disease: An update on Pathology and Therapeutics
Symposium
Universidade do Porto Faculdade de Engenharia, Portugal
2022 - 2022 Chair - VI Symposium Portuguese Glial Network
Symposium
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - 2022 Poster at The Future of Redox Biology, Siena, Italy (last author)
Meeting
 The Future of Redox Biology
2020 - 2020 Session Chair - Neurosciences session, YES Meeting
Meeting
2019 - 2019 Session Chair - XIV European Meeting on Glial Cells in Health and Disease
Meeting
2019 - 2019 Session Chair - XVI Meeting of the Portuguese Society for Neurosciences, Lisbon
Meeting
2019 - 2019 Session Chair - Glial Diversity in Neuromodulation and Neurodegeneration, IV Portuguese Glial Network Symposium
Symposium
2019 - 2019 Poster at XIV European Glial meeting, Glial Cells in Health and Disease Porto, Portugal (last author)
Meeting
2019 - 2019 Poster at 16th Meeting of the Portuguese Society of Neurosciences, Lisbon, Portugal (last author)
Meeting
 16th Meeting of the Portuguese Society of Neurosciences
2018 - 2018 Chair - III Symposium Portuguese Glial Network
Symposium
2017 - 2017 Poster at XIII European Glial meeting, Glial Cells in Health and Disease, Edinburgh, UK (last author)
Meeting
 XIII European Glial meeting, Glial Cells in Health and Disease
2016 - 2016 Session Chair - Brain without boarders
2015 - 2015 XII European Glial meeting, Glial Cells in Health and Disease, Bilbao, Spain
Meeting
 XII European Glial meeting, Glial Cells in Health and Disease
2015 - 2015 Poster at 15th Meeting of the Portuguese Society for Neurosciences, Póvoa do Varzim, Portugal (last author)
Meeting
 15th Meeting of the Portuguese Society for Neurosciences
2013 - 2013 Poster at 13th Meeting of the Portuguese Society for Neurosciences, Luso, Portugal (last author)
Meeting
 13th Meeting of the Portuguese Society for Neurosciences
2012 - 2012 Poster at 42nd Meeting of the Society of Neuroscience, New Orleans, USA (last author)
Meeting
2011 - 2011 Poster at 23rd ISN-ESN Meeting 2011 Athens, Greece (last author)
Meeting
 23rd ISN-ESN Meeting 2011
2011 - 2011 Poster at 41st Meeting of the Society of Neuroscience, Washington, DC, USA (last author)
Meeting
 41st Meeting of the Society of Neuroscience
2009 - 2009 Poster at IX European Glial meeting, Glial Cells in Health and Disease, Paris, France (last author)
Meeting
 IX European Glial meeting, Glial Cells in Health and Disease
2009 - 2009 Poster at 11th Meeting of the Portuguese Society for Neurosciences, Lisbon, Portugal (last author)
Meeting
 11th Meeting of the Portuguese Society for Neurosciences
2008 - 2008 Poster at Federation of European Neuroscience Societies Forum, Geneva, Switzerland (last author)
Meeting
 Federation of European Neuroscience Societies Forum
2008 - 2008 Poster at Gordon Research Conference on Myelin, Il Ciocco, Italy (last author)
Conference
 Gordon Research Conference on Myelin
2007 - 2007 Poster at 10th Meeting of the Portuguese Society for Neurosciences, Ofir, Portugal (last author)
Meeting
 10th Meeting of the Portuguese Society for Neurosciences
2006 - 2006 Poster at D-Biol Symposium (ETH) Davos, Switzerland (last author)
Symposium
 D-Biol Symposium (ETH)
2005 - 2005 Poster at Satellite Meeting of the International and European Society for Neurochemistry (ISN/ESN) on Myelin Development and Function, Irsee, Germany (last author)
Meeting
 Satellite Meeting of the International and European Society for Neurochemistry (ISN/ESN) on Myelin Development and Function
2004 - 2004 Poster at Federation of European Neuroscience Societies Forum, Lisbon, Portugal (last author)
Meeting
 Federation of European Neuroscience Societies Forum

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023 PhD in Ageing and Chronic Diseases (PhDOC)
(Thesis) Main arguer
 Joana Rodrigues (PhD)
2021 GABBA doctoral Program
Thesis Member
 Vitoria Brugada (PhD)
2020 PhD in Ageing and Chronic Diseases (PhDOC)
(Thesis) Main arguer
 Sofia Neves (PhD)
2020 PhD thesis, Department of Experimental Medical Science
(Thesis) Main arguer
 Carla Azevedo (PhD)
2020 PhD in Health Sciences
(Thesis) Main arguer
 Susana Monteiro (PhD)
2018 PhD in Biomedical Engineering
(Thesis) Main arguer
 Ana Rita Bento (PhD)
2018 PhD in Pharmacy
(Thesis) Main arguer
 Gisela Santos (PhD)
2018 Doctoral thesis of the Inter-University Doctoral Program in Aging and Chronic Diseases
(Thesis) Main arguer
 Vanessa Coelho-Santos (PhD)
2018 PhD in Experimental Biology and Biomedicine Neurosciences and Disease
(Thesis) Main arguer
 Patrícia Morais (PhD)
2018 PhD in Experimental Biology and Medicine
(Thesis) Main arguer
 Dominique Fernandes (PhD)
2018 PhD in Neuroscience Carla Jeres (PhD)
2018 PhD in pharmacy
(Thesis) Main arguer
 Andreia Barateiro (PhD)
2018 PhD in Biomedical Sciences
Thesis Member
 Ana Rita Malheiros (PhD)
2018 GABBA doctoral Program
Thesis Member
 Filipa Neto (PhD)
2018 Doctoral Program in Neurosciences
Thesis Member
 Carina Fernandes (PhD)
2017 PhD in Experimental Biology and Biomedicine Neurosciences and Disease
(Thesis) Main arguer
 Blanka Kerlenmeyer (PhD)
2017 PhD in Biomedical Sciences
Thesis Member
 Filipa Franquinho (PhD)
2017 PhD Program in Biomedical Sciences
Thesis Member
 Tiago Silva (PhD)
2016 PhD in Experimental Biology and Biomedicine, Neurosciences and Disease
(Thesis) Main arguer
 Mariana Pinto (PhD)
2014 PhD in Experimental Biology and Medicine, Neurosciences and Disease
(Thesis) Main arguer
 Graciano Leal (PhD)
2014 PhD Program in Biomedical Sciences
Thesis Member
 Maria Teresa Pinto de Almeida (PhD)
2013 PhD in Biochemistry
(Thesis) Main arguer
 Ana Rosa Silva (PhD)
2013 PhD in Cell Biology
(Thesis) Main arguer
 Bruno Carreira (PhD)
2013 PhD in Biomedicine
Thesis Member
 Jorge Ferreira (PhD)
2013 GABBA doctoral Program
Thesis Member
 André Sousa (PhD)
2012 PhD thesis, School of Medicine and Veterinary Medicine
(Thesis) Main arguer
 Ana Cristina Fonseca (PhD)
2012 PhD in Biomedical Sciences
Thesis Member
 Catarina Miranda (PhD)
2011 Doctoral Program in Neurosciences
Thesis Member
 Carla Morgado (PhD)
2009 PhD In Biomedical Sciences (Neurosciences)
(Thesis) Main arguer
 Susana Rocha (PhD)
2009 PhD in Biomedicine
(Thesis) Main arguer
 Ana Luísa Pereira (PhD)
2008 PhD in Cell Biology
(Thesis) Main arguer
 PhD in Cell Biology (PhD)
2008 PhD in Cell Biology
(Thesis) Main arguer
 Liliana Bernardino (PhD)
2007 PhD thesis, Eidgenössische Technische Hochschule ETH Zürich
(Thesis) Main arguer
 François Castagner (PhD)

Association member

Society Organization name Role
2008 - Current Sociedade Portuguesa de Neurociências
2006 - Current American Society for Neuroscience

Committee member

Activity description
Role 		Institution / Organization
2024 - Current Member of the Executive Board of Network Glial (Treasurer) - Max Delbruck Center for Molecular Medicine (MDC), Berlin
2024 - Current Member of the External Advisory Board of the Achucarro Basque Centre for Neurosciences
2022 - Current Member of the History of Neuroscience Committee - Federation of the European Neuroscience Societies (FENS)
Member
2019 - Current GABBA-Graduate Program in Areas of Basic and Applied Biology
Coordinator
2017 - Current Co-founder and Member of the Board of the Portuguese Glial Network
Member
2016 - Current Member of the Scientific Committee for Fundação Bial
Member
2023 - 2025 Member of the International Society of Neuroscience Advanced School Committee - International Society of Neuroscience (ISN)
Member
2017 - 2023 Member of the Network Glia - Max Delbruck Center for Molecular Medicine (MDC), Berlin
2015 - 2023 Member of the Scientific Committee of Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto
Member
2010 - 2023 Member of the Scientific and Executive Committees of Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto
Member
2018 - 2020 Member of the Scientific and Executive Committee of the Discoveries Centre for Regenenrative and Precision Medicine
Member
2013 - 2016 Member and vice-president of the Scientific Committee for Life and Health Sciences of Fundação para a Ciência e a Tecnologia

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2009 - Current Selection Committee for the Graduate Program in Areas of Basic and Applied Biology (GABBA) Universidade do Porto, Portugal
2009 - Current Membro do Quadro de Avaliação de Doutoramento e Pós-Doutoramento (Biomedicina) - Fundação para a Ciência e Tecnologia (FCT- https://www.fct.pt)
Member
2006 - 2007 Selection Committee for admission to the International PhD Program in Neurosciences Eidgenössische Technische Hochschule Zürich, Switzerland

Mentoring / Tutoring

Topic Student name
2014 - Current PhD Program in Biomedical Sciences Sérgio Leite

Other jury / evaluation

Activity description Institution / Organization
2024 - Current Member of the Maria de Sousa Prize jury Fundação Bial, Portugal
2019 - Current Editorial board of Glia
2018 - Current Editorial Board- Glia
2018 - Current Editorial Board of Frontiers in Molecular Neuroscience
2012 - Current Editorial Board - Plos One
2012 - Current Editorial Board of Plos One
2011 - Current Editorial Board - Developmental Neuroscience
2000 - Current Ad hoc reviewer: Acta Neuropathologica, Advanced Biology, Brain Research, Cell and Molecular Life Sciences, Development, Developmental Biology, Developmental Neuroscience, European Journal Neuroscience, European Journal of Cell Biology, ELife, Experimental Neurology, FEBS Letters, Frontiers in Molecular Neuroscience, Frontiers in Cellular and Molecular Neuroscience, Glia, Human Molecular Genetics, iScience, Journal of Biological Chemistry, Journal of Neurochemistry, Journal of Neurological Sciences, Nature Communications, Neuroscience Letters
2000 - Current Ad hoc reviewer: Neurobiology of Disease, Neuroscience, Plos One, Scientific Reports, The Journal of Cell Biology, The Journal of Cell Science, The Journal of Neuroscience
2000 - Current Reviewer for Funding Agencies: ARSEP Multiple Sclerosis France, Austrian Science Fund (FWF), Bial Foundation, European Science Foundation, French National Research Foundation (ANR), Fundação para a Ciência e a Tecnologia (FCT), Israel Science Foundation (ISF), LaCaixa Foundation, Medical Research Council (MRC), Multiple Sclerosis Society Canada, Multiple Sclerosis Society Australia, National Science Foundation (NSF), Netherlands Organisation for Scientific Research (NWO)! Santa Casa da Misericórdia, Stichting Alzheimer Onderzoek, ETH
2023 - 2023 Assessment Committee Member on the Appointment of an Assistant Professorship in Developmental Biology, Faculty of Science, University of Lisbon
2011 - 2023 Editorial Board of Developmental Neuroscience
2022 - 2022 Assessment Committee on the Appointment of an Assistant Professorship in Neurobiology, Faculty of Science, University of Lisbon
2018 - 2018 Assessment Committee on the Appointment of Tenure Track/Associate Professorships in Molecular Cell Biology, Department of Molecular Biology and Genetics, Aarhus University, Denmark
2013 - 2013 Assessment Committee on the Appointment for a Promotion to a Professorial Research Fellowship or a Readership in Faculty of Medicine and Dentistry, University of Bristol, UK
Distinctions

Other distinction

2001 EMBO Short Term Fellowship
1997 Post-doctoral Fellowship from Programa Praxis XXI (BPD/11785/97)
1995 Fellowship Muscular Dystrophy UK
1991 PhD Fellowship from Programa Praxis XXI (BD/1108/90)