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Laura Maria Alcântara completed the Ph.D from Universidade Estadual de Campinas, UNICAMP, in 2017. She has published 15 articles in peer-reviewed journals, one preprint article, and 2 book chapters, accumulating more than 470 citations to the date (h index = 12). The main research developed by L. M. Alcântara is in the fields of Microbiology and Parasitology. During her Ph.D and Postdoctoral training, her main activities have been focused on the establishment of in vitro infection models and high-content infection assays. She has performed multiple large-scale screenings with libraries of compounds/natural products, and drug combination/repurposing screenings. L. M. Alcântara worked as a MSCA Postdoctoral researcher (Marie Sklodowska-Curie fellowship), at the RNA & Infection laboratory (CNC/CIBB, University of Coimbra, Portugal), under the supervision of Dr. Ana Eulalio. Her studies are focused on drug/functional screenings and host-pathogen interactions, particularly in infection with Staphylococcus aureus.
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Identification

Personal identification

Full name
Laura Maria Alcântara

Citation names

  • Alcântara, Laura

Author identifiers

Ciência ID
2D1B-41ED-642B
ORCID iD
0000-0002-3374-7405

Addresses

  • UC-Biotech/Biocant - Parque Tecnológico de Cantanhede, núcleo 4, lote 8. , 3060-197, Cantanhede, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2013/03 - 2017/07
Concluded
 Doutorado em Genética e Biologia Molecular (Doutoramento)
Universidade Estadual de Campinas, Brazil
"Discovery of new drug candidates for visceral leishmaniasis treatment: from image-based assay development to in vitro compounds screening." (THESIS/DISSERTATION)
2007/08 - 2012/08
Concluded
 Engenharia Biotecnológica (Bachelor)
Universidade Estadual Paulista "Júlio de Mesquita Filho" - UNESP, Brazil
" In vitro chemosensitization effects of tyrosine kinase and third generation P-glycoprotein inhibitors on multidrug resistant malaria." (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2020/10 - Current Postdoc (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/04 - 2020/09 Postdoc (Research) Instituto do Coração do Hospital das Clínicas da FMUSP - Incor, Brazil
Instituto do Coração do Hospital das Clínicas da FMUSP - Incor, Brazil
2017/11 - 2019/03 Postdoc (Research) Universidade de São Paulo, Brazil
Universidade de São Paulo, Brazil

Others

Category
Host institution 		Employer
2019/08 - 2019/11 Visiting scientist Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/03 - 2017/07 PhD fellow Laboratório Nacional de Biociências, Brazil
2016/11 - 2016/12 Visiting scientist Universiteit Antwerpen, Belgium
Universiteit Antwerpen, Belgium
2011/07 - 2012/06 Research Trainee Institut Pasteur Korea , South Korea
Institut Pasteur Korea , South Korea
2010 - 2011 Research trainee Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brazil
2009 - 2011 Junior Enterprise Organization Junior Enterprise Organization - Biotech Junior, Brazil
Projects

Grant

Designation Funders
2020/10 - 2022/10 Functional high-throughput analysis of the role of microRNAs in regulating Staphylococcus aureus infection (miRs4Staph)
893942
Post-doc Fellow
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2019/04 - 2020/09 New therapies for Chagas Disease: repurposing of drugs with synergistic effect with Benznidazole to counteract Trypanosoma cruzi infection
CAPES/FCT - 28/2017
Post-doc Fellow
Instituto do Coração do Hospital das Clínicas da FMUSP - Incor, Brazil
 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação para a Ciência e a Tecnologia
Concluded
2017/11 - 2019/03 Development of secondary in vitro assays for Chagas disease and leishmaniasis early drug discovery.
VPPIS-003-PPE-15-2-6
Post-doc Fellow
Universidade de São Paulo, Brazil
 Drugs for Neglected Diseases initiative
Concluded
2017 - 2018 Identification of starting points for drug discovery and target identification against major neglected diseases
MMV2016
Post-doc Fellow
Universidade de São Paulo, Brazil
 Medicines for Malaria Venture
Concluded
2013/03 - 2017/03 Discovery of new drug candidates for visceral leishmaniasis treatment: from image-based assay development to in vitro compounds screening
140907/2013-0
PhD Student Fellow
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded

Contract

Designation Funders
2022/01 - 2023/11 Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains.
EXPL/BIA-MIC/1251/2021
Co-Principal Investigator (Co-PI)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/10 - 2022/10 Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains
POCI-01-0145-FEDER-029999
Team Member
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014 - 2017 NMTrypl - New Drugs for Trypanosomatidic Infections
603240
Team Member
Centro Nacional de Pesquisa em Energia e Materiais, Brazil
 European Commission Seventh Framework Programme for Research and Technological Development
Concluded
Outputs

Publications

Book chapter
  1. Ariely Barbosa Leite; Ana Caroline Nascimento Castro; Franco, C.H.; Alcântara, Laura; Leila Maria dos Santos Moura; Elton J. R. Vasconcelos; Rubens Lima do Monte Neto; Moretti, Nilmar Silvio. "Fármacos usados nos tratamentos das protozooses e das ectoparasitoses". In Livro-Texto De Farmacologia - Casos Clínicos E Atividades Didáticas. São Paulo, Brazil: Atheneu, 2020.
    Published
  2. Moraes, Carolina Borsoi; Alcântara, Laura Maria. "Quantification of Parasite Loads by Automated Microscopic Image Analysis". In Methods in Molecular Biology, 279-288. Springer New York, 2019.
    Published • 10.1007/978-1-4939-9210-2_15
Conference abstract
  1. Alcântara, Laura; Savoia, M; Vieira, R; Almeida, R; Nunes, J P; Lopes, I; Kalil, J; Mano, M; Cunha-Neto, E. "High-content screening of FDA-approved drugs in combination with benznidazole reveals potential anti-Trypanosoma cruzi agents". Paper presented in XXXVII Annual Meeting of the Brazilian Society of Protozoology / XLVIII Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2022.
  2. Alcântara, Laura; Franco, C; Lopes, I; Mano, M; Eulalio, A. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in Cold Spring Harbor Laboratory Conference Microbial Pathogenesis & Host Response, Cold Spring Harbor, 2021.
  3. Alcântara, Laura; Ferreira, T; Franco, C; Schenkman, S; Freitas-Junior, L; Moraes, C. Corresponding author: Moraes, C. "Screening of the Pathogen Box library for discovery of broad-spectrum anti-trypanosomatidic agents". Paper presented in XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2018.
  4. Moraes, C; Alcântara, Laura; Kebede, B; Wolf, M; Karunakaran, D; Fontana, V; Ferreira, T.C.S.; et al. "Discovery of anti-leishmanial compounds from natural sources.". Paper presented in 6th World Congress on Leishmaniasis (World Leish), Toledo, 2017.
  5. Ferreira, T; Alcântara, Laura; Miguel, D; Chatelain, E; Moraes, C; Freitas-Junior, L. "Development of Leishmania secondary assays for Drug Discovery: in vitro-in vivo translation using high content screening". Paper presented in 6th World Congress on Leishmaniasis (World Leish), Toledo, 2017.
  6. Alcântara, Laura; Ferreira, T; Fontana, V; Moraes, C; Freitas-Junior, L; Chatelain, E. "A multi-species high content screening assay for the discovery of broad spectrum antileishmanial drugs". Paper presented in 6th World Congress on Leishmaniasis (World Leish), Toledo, 2017.
  7. Alcântara, Laura; Franco, C; Fontana, V; Moraes, C; Freitas-Junior, L. "Development and validation of a high content assay for Leishmania chagasi infected THP-1 cells.". Paper presented in XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2015.
Conference poster
  1. Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. Corresponding author: Alcântara, Laura. "Functional high-throughput screening identifies microRNAs regulating Staphylococcus aureus intracellular lifestyle". Paper presented in RNA biology in host-pathogen interactions - Epiviral conference, 2024.
  2. Laura Maria Alcântara; Caio Haddad Franco; Ines Rodrigues Lopes; Miguel Mano; Ana Eulalio. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in RNA in disease - IX ptRNA meeting, 2023.
  3. Lopes, Inês Rodrigues; Alcântara, Laura; Silva, Ricardo Jorge; Josse, Jerome; Vega, Elena Pedrero ; Cabrerizo, Ana Marina; Bonhomme, Melanie; et al. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Paper presented in EMBO| EMBL Symposium: New Approaches and Concepts in Microbiology, 2023.
  4. Laura Maria Alcântara; Marilda Nascimento Savoia; Raquel de Souza Vieira; Rafael Ribeiro Almeida ; João Paulo Silva Nunes; Ines Rodrigues Lopes; Jorge Kalil ; Miguel Mano; Edecio Cunha Neto. "High-content screening of FDA-approved drugs in combination with benznidazole reveals potential anti-Trypanosoma cruzi agents". Paper presented in XXXVII Annual Meeting of the Brazilian Society of Protozoology / XLVIII Annual Meeting on Basic Research in Chagas Disease, 2022.
  5. Laura Maria Alcântara; Caio Haddad Franco; Ines Rodrigues Lopes; Miguel Mano; Ana Eulalio. Corresponding author: Ana Eulalio. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in Cold Spring Harbor Laboratory Conference Microbial Pathogenesis & Host Response, 2021.
  6. Franco, Caio; Alcântara, Laura; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in EMBO| EMBL Symposium: New Approaches and Concepts in Microbiology, 2021.
  7. Santos, Gregory Pedroso; Abukawa, Fernanda Midori; Souza-Melo, Normanda; Alcântara, Laura; Moretti, Nilmar; McGwire, Bradford S.; Schenkman, Sergio. "Cyclophilin 19 a new player in oxidative stress during Trypanosoma cruzi infection.". Paper presented in British Society for Parasitology BSP Trypanosomiasis & Leishmaniasis Seminar, 2020.
  8. Souza-Melo, Normanda; Rodrigues, DM; Malvezzi, Amaranta Muniz; Alcântara, Laura; Moretti, Nilmar; Santos, Gregory Pedroso; Torrecilhas, Ana Claudia; Schenkman, Sergio. "Characterization of components of the endosomal sorting in Trypanosoma cruzi". Paper presented in XXXVII Annual Meeting of the Brazilian Society of Protozoology / XLVIII Annual Meeting on Basic Research in Chagas Disease, 2019.
  9. Santos, Gregory Pedroso; Abukawa, Fernanda Midori; Moretti, Nilmar; Souza-Melo, Normanda; Alcântara, Laura; McGwire, Bradford S.; Schenkman, Sergio. "Cyclophilin 19 a new player in oxidative stress during Trypanosoma cruzi infection". Paper presented in XXXVII Annual Meeting of the Brazilian Society of Protozoology / XLVIII Annual Meeting on Basic Research in Chagas Disease, 2019.
  10. Santos, Gregory Pedroso; Abukawa, Fernanda Midori; Souza-Melo, Normanda; Alcântara, Laura; Moretti, Nilmar; McGwire, Bradford S.; Schenkman, Sergio. "Cyclophilin 19 a new player in oxidative stress during Trypanosoma cruzi infection". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, Woods Hole, 2019.
  11. Souza-Melo, Normanda; Silva, Natalia; Santos, Gregory Pedroso; Alcântara, Laura; Malvezzi, Amaranta Muniz; Schenkman, Sergio. "Characterization of Deubiquitinases involved in endocytic pathway in T. cruzi.". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, Woods Hole, 2019.
  12. Tropéia, Naomi; Alcântara, Laura; Franco, Caio; Moraes, Carolina B.; Fisher, Dominique. "Chemical composition and Trypanocidal activity evaluation of the volatile oil from Mentha pulegium L.". Paper presented in International Phytocosmetics and Phytotherapy Congress/IPPC, 2019.
  13. Souza-Melo, Normanda; Silva, Natalia; Santos, Gregory Pedroso; Alcântara, Laura; Schenkman, Sergio. "The role of Trypanosoma cruzi deubiquitinases in protein secretion and surface protein turnover". Paper presented in XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, 2018.
  14. Thalita Camelo Ferreira ; Laura Maria Alcântara; Danilo Ciccone Miguel ; Eric Chatelain ; Carolina Borsoi Moraes; Lucio Freitas-Junior. "Development of Leishmania secondary assays for Drug Discovery: in vitro-in vivo translation using high content screening". Paper presented in 6th World Congress on Leishmaniasis, 2017.
  15. Alcântara, Laura; Ferreira, T; Fontana, V; Moraes, C; Freitas-Junior, L; Chatelain, E. "A multi-species high content screening assay for the discovery of broad spectrum antileishmanial drugs". Paper presented in 6th World Congress on Leishmaniasis (World Leish), 2017.
  16. Moraes, C; Alcântara, Laura; Kebede, B; Wolf, M; Karunakaran, D; Ferreira, T; Fontana, V; et al. "Discovery of anti-leishmanial compounds from natural sources.". Paper presented in 6th World Congress on Leishmaniasis (World Leish), 2017.
  17. Laura Maria Alcântara; Caio Haddad Franco; Vanessa Fontana; Carolina Borsoi Moraes; Lucio Freitas-Junior. Corresponding author: Lucio Freitas-Junior. "Development and validation of a high content assay for Leishmania chagasi infected THP-1 cells". Paper presented in XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, 2015.
  18. Laura Maria Alcântara; Vanessa Fontana; Carolina Borsoi Moraes; Lucio Freitas-Junior. "Development and validation of an image-based assay for Leishmania chagasi infection in THP-1 cells". Paper presented in São Paulo School of Advanced Sciences on Neglected Disease Drug Discovery Focus on Kinetoplastids, 2015.
Journal article
  1. Alcântara, Laura; Franco, Caio; Moretti, Nilmar; Pilger, Denise. "Editorial: Drug discovery for emerging and neglected tropical diseases: advances, challenges and perspectives". Frontiers in Drug Discovery 3 (2023): http://dx.doi.org/10.3389/fddsv.2023.1346042.
    Published • 10.3389/fddsv.2023.1346042
  2. Rodrigues Lopes, Ines; Alcantara, Laura Maria; Silva, Ricardo Jorge; Josse, Jerome; Vega, Elena Pedrero; Cabrerizo, Ana Marina; Bonhomme, Melanie; et al. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-34790-9.
    Published • 10.1038/s41467-022-34790-9
  3. Pandey, Ramendra P.; Nascimento, Marilda Savoia; Franco, Caio Haddad; Bortoluci, Karina; Silva, Marcelo Nunes; Zingales, Bianca; Gibaldi, Daniel; et al. Corresponding author: Cunha-Neto, Edecio. "Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo". Antimicrobial Agents and Chemotherapy (2022): http://dx.doi.org/10.1128/aac.00284-22.
    Published • 10.1128/aac.00284-22
  4. Santos, Gregory Pedroso; Abukawa, Fernanda Midori; Souza-Melo, Normanda; Alcântara, Laura Maria; Bittencourt-Cunha, Paula; Moraes, Carolina Borsoi; Jha, Bijay Kumar; et al. "Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth". Cellular Microbiology e13295 (2020): http://dx.doi.org/10.1111/cmi.13295.
    Published • 10.1111/cmi.13295
  5. Alcântara, Laura M.; Ferreira, Thalita C. S.; Fontana, Vanessa; Chatelain, Eric; Moraes, Carolina B.; Freitas-Junior, Lucio H.. "A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity". Molecules 25 11 (2020): 2551. http://dx.doi.org/10.3390/molecules25112551.
    Published • 10.3390/molecules25112551
  6. Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al. "Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes". International Journal of Molecular Sciences 21 10 (2020): 3659. http://dx.doi.org/10.3390/ijms21103659.
    Published • 10.3390/ijms21103659
  7. Franco, Caio Haddad; Alcântara, Laura Maria; Chatelain, Eric; Freitas-Junior, Lucio; Moraes, Carolina Borsoi. "Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection". Tropical Medicine and Infectious Disease 4 2 (2019): 82. http://dx.doi.org/10.3390/tropicalmed4020082.
    Published • 10.3390/tropicalmed4020082
  8. Alcântara, Laura M.; Ferreira, Thalita C.S.; Gadelha, Fernanda R.; Miguel, Danilo C.. "Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis". International Journal for Parasitology: Drugs and Drug Resistance 8 3 (2018): 430-439. http://dx.doi.org/10.1016/j.ijpddr.2018.09.006.
    Published • 10.1016/j.ijpddr.2018.09.006
  9. Linciano, Pasquale; Moraes, Carolina B.; Alcantara, Laura M.; Franco, Caio H.; Pascoalino, Bruno; Freitas-Junior, Lucio H.; Macedo, Sara; et al. "Aryl thiosemicarbazones for the treatment of trypanosomatidic infections". European Journal of Medicinal Chemistry 146 (2018): 423-434. http://dx.doi.org/10.1016/j.ejmech.2018.01.043.
    Published • 10.1016/j.ejmech.2018.01.043
  10. Federico, Leonardo B.; Alcântara, Laura M.; Moraes, Carolina B.; Freitas-Junior, Lucio H.; M. C. Rosa, Joaquín; H. T. P. Silva, Carlos. "Discovery of Novel Leishmanicidal Drugs with Potential L-type Calcium Channel Blockage, Designed by Similarity-Based Virtual Screening Approaches". POJ Pharmaceutical Sciences (2017): 01-06. http://dx.doi.org/10.32648/pojpharmasci/01.
    Published • 10.32648/pojpharmasci/01
  11. Linciano, Pasquale; Dawson, Alice; Pöhner, Ina; Costa, David M.; Sá, Monica S.; Cordeiro-da-Silva, Anabela; Luciani, Rosaria; et al. "Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery". ACS Omega 2 9 (2017): 5666-5683. http://dx.doi.org/10.1021/acsomega.7b00473.
    Published • 10.1021/acsomega.7b00473
  12. Gomes, Marcelo N.; Alcântara, Laura M.; Neves, Bruno J.; Melo-Filho, Cleber C.; Freitas-Junior, Lucio H.; Moraes, Carolina B.; Ma, Rui; et al. "Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum". Bioorganic & Medicinal Chemistry Letters 27 11 (2017): 2459-2464. http://dx.doi.org/10.1016/j.bmcl.2017.04.010.
    Published • 10.1016/j.bmcl.2017.04.010
  13. Di Pisa, Flavio; Landi, Giacomo; Dello Iacono, Lucia; Pozzi, Cecilia; Borsari, Chiara; Ferrari, Stefania; Santucci, Matteo; et al. "Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity". Molecules 22 3 (2017): 426. http://dx.doi.org/10.3390/molecules22030426.
    Published • 10.3390/molecules22030426
  14. Borsari, Chiara; Santarem, Nuno; Torrado, Juan; Olías, Ana Isabel; Corral, María Jesús; Baptista, Catarina; Gul, Sheraz; et al. "Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds". European Journal of Medicinal Chemistry 126 (2017): 1129-1135. http://dx.doi.org/10.1016/j.ejmech.2016.12.017.
    Published • 10.1016/j.ejmech.2016.12.017
  15. Alcantara, Laura M.; Kim, Junwon; Moraes, Carolina B.; Franco, Caio H.; Franzoi, Kathrin D.; Lee, Sukjun; Freitas-Junior, Lucio H.; Ayong, Lawrence S.. "Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites". Experimental Parasitology 134 2 (2013): 235-243. http://dx.doi.org/10.1016/j.exppara.2013.03.022.
    Published • 10.1016/j.exppara.2013.03.022
Online resource
  1. Alcântara, Laura; Eulalio, Ana. Novel host factors against Staphylococcus aureus infection discovered. 2023. https://cordis.europa.eu/article/id/443000-novel-host-targets-against-staphylococcus-aureus-infection?WT.mc_id=exp.
    10.3030/893942
Preprint
  1. Souza-Melo, Normanda; Brito Silva, Nathalia; Malvezzi, Amaranta Muniz; dos Santos, Gregory Pedroso; Alcântara, Laura Maria; de Lima Alcantara, Carolina; da Cunha e Silva, Narcisa Leal; et al. "Trypanosoma cruzi VDU deubiquitinase mediates surface protein trafficking and infectivity". 2023. http://dx.doi.org/10.1101/2023.04.17.537123.
    10.1101/2023.04.17.537123
Thesis / Dissertation
  1. "Discovery of new drugs candidates for visceral leishmaniasis treatment: from image-based assay development to in vitro compounds screening". PhD, Universidade Estadual de Campinas, 2017.
  2. "In vitro chemosensitization effects of tyrosine kinase and third generation P-glycoprotein inhibitors on multidrug resistant malaria". Degree, Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, 2012.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06/04 Functional high-throughput screening identifies microRNAs regulating Staphylococcus aureus intracellular lifestyle RNA biology in host-pathogen interactions - Epiviral conference
University of Aveiro (Porto, Portugal)
2019/12/04 Translational research and drug discovery for tropical neglected diseases: Strategies based on drug combination and repurposing. Weekly Seminars at FMUSP Heart Institute (InCor)
FMUSP Heart Institute (InCor) (São Paulo, Brazil)
2018/11/06 Screening of the Pathogen Box library for discovery of broad-spectrum anti-trypanosomatidic agents. XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease
Brazilian Society of Protozoology (Caxambu, Minas Gerais, Brazil)
2015/07/20 Speaker at a mini-course at Open Congress for Biology Students - Leishmania high content screenings Open Congress for Biology Students
Universidade Estadual de Campinas/CAEB (Campinas, SP, Brazil)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - 2022 Effect of drug combinations on different stages of T. cruzi infection: study in strains belonging to different DTUs.
Co-supervisor of Marilda Savoia Nascimento
 Tropical Medicine (PhD)
Instituto de Medicina Tropical - Faculdade de Medicina USP, Brazil

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021 - 2021 Volunteer of the 2021 edition of European Researchers´s Night - Coimbra (2021/09/24 - 2021/09/24)
Exhibition (Other)
 Universidade de Coimbra, Portugal
2018 - 2018 Member of the organizing committee of this 2-days international event: Tools and Platforms for phenotypic Drug Discovery (150 attendees) (2018 - 2018)
Conference (Member of the Organising Committee)
 Universidade de São Paulo, Brazil

Drugs for Neglected Diseases initiative, Switzerland
2015 - 2015 Member of the organizing committee of this 2-weeks event: Sao Paulo School of Advanced Science on Neglected Diseases Drug Discovery – focus on Kinetoplastids (80 participants) (2015 - 2015)
Other (Member of the Organising Committee)
 Centro Nacional de Pesquisa em Energia e Materiais, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
2015 - 2015 Member of the organizing committee of the meeting Building International Consortia on parasitic diseases: the NMTrypl experience (100 participants) (2015 - 2015)
Meeting (Member of the Organising Committee)
 Laboratório Nacional de Biociências, Brazil
2010 - 2010 Member of the organizing committee of the course "Molecular Biology: basis and applications" (2010)
Workshop (Member of the Organising Committee)
 Junior Enterprise Organization - Biotech Junior, Brazil
2010 - 2010 Coordinator of the "XIV EnEJUnesp - Meeting of Junior Enterprise Organizations (2010)
Meeting (Co-organisor)
 Junior Enterprise Organization - Biotech Junior, Brazil

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/11/25 - 2024/11/27 Attended the "EU-OPENSCREEN AUTUMN TRAINING SCHOOL 2024"
Other
 EU-OPENSCREEN AUTUMN TRAINING SCHOOL 2024
EU-OPENSCREEN Consortium, Germany
2024/09/24 - 2024/09/24 Participant investigator of the 2024 edition of European Researchers´ Night – Coimbra, Portugal. Activity: Super bugs: the invisible threat!
Exhibition
 European Researchers´ Night
Universidade de Coimbra, Portugal
2024/07/29 - 2024/07/29 Participant investigator of the ’Science Studio’ initiative - EXPOFACIC-2024. Activity: Super bugs: the invisible threat!
Exhibition
Universidade de Coimbra, Portugal
2024/06/04 - 2024/06/07 Attended the EpiViral conference "RNA biology in host-pathogen interactions" (Flask Talk and Poster presentation)
Conference
 EpiViral conference - RNA biology in host-pathogen interactions
Universidade de Aveiro, Portugal
2024/02/06 - 2024/02/06 Attended the "Antimicrobial Chemotherapy Conference 2024"
Conference
 Antimicrobial Chemotherapy Conference 2024
2023/09/29 - 2023/09/29 Participant investigator of the 2023 edition of European Researchers´ Night – Coimbra, Portugal. Activity: Super bugs: the invisible threat!
Exhibition
 European Researchers´ Night
Universidade de Coimbra, Portugal
2023/01/26 - 2023/01/27 Attended the RNA in disease - IX ptRNA meeting
Meeting
 RNA in disease - IX ptRNA meeting
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2022/09/30 - 2022/09/30 Participant investigator of the 2022 edition of European Researchers´ Night – Coimbra, Portugal. Activity: Super bugs: the invisible threat!
Exhibition
 European Researchers' Night
Universidade de Coimbra, Portugal
2022/08/22 - 2022/08/24 Attended the XXXVII Annual Meeting of the Brazilian Society of Protozoology / XLVIII Annual Meeting on Basic Research in Chagas Disease
Meeting
 XXXVII Annual Meeting of the Brazilian Society of Protozoology / XLVIII Annual Meeting on Basic Research in Chagas Disease
SBPz - Brazilian Society of Protozoology, Brazil
2022/02/21 - 2022/02/25 Attended (virtually) the Advanced Course : High-Throughput Screening for Target and Drug Discovery
Workshop
 PDBEB course: High-Throughput Screening for Target and Drug Discovery
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/10/27 - 2021/10/27 Attended the webinar: From Base Pairs to Bedside: Antisense Modulation of RNA Splicing by Adrian Krainer.
Seminar
 1st International ICBAS Webinar Series
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10/13 - 2021/10/13 Attended the webinar: Witnessing the fifty-year gene revolution: from single genes and their messenger RNAs to genomes and their transcriptomes, by Nick Proudfoot
Seminar
 1st International ICBAS Webinar Series
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/09/21 - 2021/09/24 Attended (virtually) the Cold Spring Harbor Laboratory Conference: Microbiology Pathogenesis & Host Response
Conference
 Microbial Pathegenesis & Host Response
Cold Spring Harbor Laboratory, United States
2021/04/27 - 2021/04/27 Attended (virtually) the conference: Emerging Infectious Diseases and related environmental, clinical and translational challenges
Conference
 Emerging Infectious Diseases and related environmental, clinical and translational challenges
Universidade de Coimbra, Portugal
2019/10/04 - 2019/10/04 Attended the mini-course: How to Get Published by Elsevier
Other
 How to Get Published
Universidade de Coimbra, Portugal
2018/11/05 - 2018/11/07 Attended the international meeting: XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease
Meeting
 XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease
SBPz - Brazilian Society of Protozoology, Brazil
2018 - 2018 Attended the III Hands On Course - From Genes To Drugs: An introduction to target-based drug discovery. (80h)
Other
 From Genes To Drugs: An introduction to target-based drug discovery
Structural Genomics Consortium - UNICAMP, Brazil
2018 - 2018 Attended the international symposium on drug discovery and development held by pharmaceutic companies and research institutes.
Symposium
 Drug Discovery in Academia: learning from success and failure
Instituto Butantan, Brazil
2017/06/21 - 2017/06/23 Attended the scientific Meeting: Searching for active compounds against neglected diseases
Meeting
 III Scientific Meeting - Searching for active compounds against neglected diseases: from traditional knowledge to structural synthesis
Universidade de São Paulo, Brazil
2016/06/06 - 2016/06/10 Attended seminars on New Approaches to Drug Discovery against Tropical Diseases
Seminar
 New approaches to drug discovery against tropical diseases
Universidade Estadual de Campinas, Brazil
2016 - 2016 Attended the Course: Yeast-based high throughput approaches. (3h)
Workshop
 New approaches to drug discovery against tropical diseases
Universidade Estadual de Campinas, Brazil
2016 - 2016 Attended the Course: Primer in computer-aided drug design for tropical diseases (3h).
Workshop
 New approaches to drug discovery against tropical diseases
Universidade Estadual de Campinas, Brazil
2015/11/09 - 2015/11/11 Attended the XXXI Annual Meeting of the Brazilian Society of Protozoology / XLII Annual Meeting on Basic Research in Chagas Disease
Meeting
 XXXI Annual Meeting of the Brazilian Society of Protozoology / XLII Annual Meeting on Basic Research in Chagas Disease
SBPz - Brazilian Society of Protozoology, Brazil
2015/06/16 - 2015/06/23 Attended seminars on Drug Discovery against Neglected Diseases
Seminar
 Current Drug Discovery for Neglected Diseases
Centro Nacional de Pesquisa em Energia e Materiais, Brazil
2014 - 2014 Hands-on Course: V Curso de Microscopia Eletrônica de Transmissão (120h)
Other
 V Curso de Microscopia Eletrônica de Transmissão
Laboratório Nacional de Nanotecnologia, Brazil
2014 - 2014 Hands-on Course: Data Analysis using the Software KNIME (8h)
Meeting
 1º Encontro Brasileiro de High Content Screening.
Fundação Hemocentro de Ribeirão Preto, Brazil
2014 - 2014 Hands-on Course: Automated Image Analysis Using the Software CellProfiler (8h)
Meeting
 1º Encontro Brasileiro de High Content Screening
Fundação Hemocentro de Ribeirão Preto, Brazil
2014 - 2014 Course: Basic Principles of High Content Screening (8h).
Meeting
 1° Encontro Brasileiro de High Content Screening
Fundação Hemocentro de Ribeirão Preto, Brazil
2013 - 2013 Worldleish 5 - Fifth World Congress on Leishmaniasis
Congress
 Worldleish 5 - Fifth World Congress on Leishmaniasis
2013 - 2013 Workshop on Drug Discovery and Neglected Tropical Diseases
Workshop
 Workshop on Drug Discovery and Neglected Tropical Diseases
Universidade Federal de São Carlos, Brazil

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/10/21 - Current Molecules (1420-3049) MDPI
2023/05/09 - Current Antimicrobial Agents and Chemotherapy (0066-4804) American Society for Microbiology

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/05/17 - 2022/05/17 Lecturer at a Specialization Program Course: Drug discovery for Chagas Disease: strategies based on drug combination and repurposing. (Especialização pós-bacharelato) Centro Universitário São Camilo, Brazil
2021/05/26 - 2021/05/26 Lecturer at a Specialization Program Course: Drug discovery for Chagas Disease: strategies based on drug combination and repurposing. (Especialização pós-bacharelato) Centro Universitário São Camilo, Brazil
2021/02/04 - 2021/02/04 Lecturer at PhD Program Course: Translational research and drug discovery for tropical neglected diseases: Strategies based on drug combination and repurposing. (Doutoramento) Universidade de Coimbra, Portugal
2020/06/23 - 2020/06/23 Lecturer at a Specialization Program Course: Desenvolvimento de Novos Fármacos - Pesquisa Clínica - Da bancada à prateleira. (Especialização pós-bacharelato) Centro Universitário São Camilo, Brazil
2015/02 - 2015/06 Professorship training program in Parasitology Parasitology (Bachelor) Universidade Estadual de Campinas, Brazil

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Pathogens (2076-0817) MDPI
2022/09 - 2024/01 Frontiers in Drug Discovery (2674-0338) Frontiers

Mentoring / Tutoring

Topic Student name
2013 - 2018 Application of high content assays in early drug discovery for neglected diseases. Several undergraduate students
Distinctions

Award

2022 MDPI John M Goldsmid Award for Best Research Article 2019-2020 (Drug Discovery for Chagas Disease: Impact of Different Host Cells Lines on Assay Performance and hit Compound Selection)
MDPI AG, Switzerland

Other distinction

2022 Postdoctoral fellowship
Universidade de Coimbra, Portugal
2020 Postdoctoral fellowship
Universidade de Coimbra, Portugal

European Commission Marie Sklodowska-Curie Actions, Belgium
2019 Postdoctoral fellowship
Universidade de São Paulo, Brazil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
2017 Postdoctoral fellowship
Universidade de São Paulo, Brazil

Drugs for Neglected Diseases initiative, Switzerland
2013 PhD fellowship
Universidade Estadual de Campinas, Brazil

Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil