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Rui V. Simões joined i3S (Institute for Research and Innovation in Health, Porto, Portugal) as an associate researcher in the Neuroengineering and Computational Neuroscience Laboratory in 2022. In 2023, he established and has since led the Preclinical MRI Unit. Rui holds a BSc in Biochemistry (University of Coimbra, Portugal, 2003) and has specialized training in preclinical magnetic resonance imaging (MRI) and spectroscopy of cancer models, acquired during his PhD (University of Coimbra, Portugal, and Autonomous University of Barcelona, Spain, 2004–2009) and postdoctoral research (Memorial Sloan Kettering Cancer Center, New York, USA, 2010–2013). His research focuses on the quantitative characterization of cellular and tissue metabolism under pathological conditions, spanning fetal growth restriction (Fetal Medicine Research Center, Barcelona, Spain, 2013–2017), neurodegeneration (Clinic Hospital, Barcelona, Spain, 2015–2017), and oncology (Champalimaud Foundation, Lisbon, Portugal, 2017–2022). At i3S, his work integrates the Neurobiology and Neurologic Disorders and Cancer programs with a translational imaging focus, contributing to the Porto Comprehensive Cancer Center “Raquel Seruca” consortium and fostering collaborations with leading clinical centers in the region, including São João and Santo António hospitals. Rui has authored over 30 peer-reviewed publications (h-index: 19), presented 76 peer-reviewed abstracts at international scientific meetings (including 21 first-author oral presentations and 3 as senior author), and delivered 21 invited talks. In the past five years, he secured competitive funding, including an H2020-MSCA-IF fellowship and a PARSUK-FCT bilateral research award. As an active member of the MRI research community, he co-founded the Iberian Chapter of the International Society for Magnetic Resonance in Medicine (ISMRM) and serves as an Executive and Management Board member of the “Glioma MRI Work Group” within the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), where he co-leads the Preclinical MRI Task Force. He is also an active member of the European Society for Molecular Imaging (ESMI).
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Identification

Personal identification

Full name
Rui Vasco Portas Ferreira Simões

Citation names

  • Simões, Rui V

Author identifiers

Ciência ID
2E17-9F8A-504C
ORCID iD
0000-0001-7574-4723

Addresses

  • Rua Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Professional)
  • Av Comendador Ferreira de Matos 856, 1D, 4450-121, Matosinhos, Matosinhos, Portugal (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Exact Sciences - Physical Sciences
  • Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Catalan Intermediate (B1) Advanced (C1) Intermediate (B1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010/02/26
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Biofísica Molecular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Towards Molecular Imaging of Preclinical Brain Tumor Models by Mrs" (THESIS/DISSERTATION)
 magna cum laude
1997/10/15 - 2003/07/27
Concluded
 Bioquímica (Licenciatura)
Major in Bioquímica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Princípios básicos das técnicas NMR/MRI e optimização das condições necessárias para estudos in-vivo de ratinhos dentro de um sistema MRI de alto campo" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2022/09/01 - Current Research Assistant (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/09/15 - 2022/08/31 Postdoc (Research) Fundação Champalimaud, Portugal
Fundação Champalimaud, Portugal
2014/01/01 - 2017/07/15 Researcher (Research) Fundación Sant Joan de Déu, Spain
Fetal Medicine Research Center, Spain
2013/05/21 - 2013/12/31 Researcher (Research) Fundació Clínic per a la Recerca Biomédica, Spain
Fetal Medicine Research Center, Spain
2010/05/21 - 2013/05/10 Postdoc (Research) Memorial Sloan Kettering Cancer Center, United States
Memorial Sloan Kettering Cancer Center, United States
2009/02/01 - 2010/05/01 Postdoc (Research) Universitat Autònoma de Barcelona, Spain
Universitat Autònoma de Barcelona, Spain
2002/09/15 - 2003/07/15 Research Trainee (Research) Universidade de Coimbra, Portugal
Universitat Autònoma de Barcelona, Spain

Others

Category
Host institution 		Employer
2005/02/01 - 2009/01/31 Estudante de Doutoramento Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universitat Autònoma de Barcelona, Spain
2003/09/15 - 2005/01/31 Técnico Investigação Universitat Autònoma de Barcelona, Spain
Universitat Autònoma de Barcelona, Spain
Projects

Grant

Designation Funders
2024/07/01 - 2024/12/31 Harnessing translational MRI for pancreatic tumor assessment (TRANSMAP)
PARSUK-FCT-BRF2024-TRANSMAP
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014/05/01 - 2017/07/15 CEREBRA
CEREBRA-UB
Research Fellow
Fetal Medicine Research Center, Spain
 Cerebra Innovation Centre
Ongoing
2009/01/01 - 2011/01/01 Phenotype and molecular imaging of brain cancer progression by MRS/MRI in murine models. Translational application to humans (PHENOIMA)
MYCT/SAF-2008-03323
PhD Student Fellow
Universitat Autònoma de Barcelona Departament de Bioquímica i Biologia Molecular, Spain
 España Ministerio de Ciencia e Innovación
Concluded
2009/01 - 2011/01 Phenotype and molecular imaging of brain cancer progression by MRS/MRI in murine models. Translational application to humans (PHENOIMA)
MYCT/SAF-2008-03323
 España Ministerio de Ciencia e Innovación
2005/02/01 - 2009/01/31 Towards Molecular imaging of preclinical brain tumor by MRS
10316/13879
PhD Student Fellow
Universitat Autònoma de Barcelona Departament de Bioquímica i Biologia Molecular, Spain
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/09/01 - 2028/08/31 Longitudinal assessment of tumor progression and treatment response with translational MRI
CEECINST/00131/2021/CP2805/CT0001
10.54499/CEECINST/00131/2021/CP2805/CT0001
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/05/03 - 2021/05/02 CHyMERA – Monitoring cancer heterogeneity based on the dynamic assessment of the Warburg effect under metabolic perturbation
H2020-MSCA-IF-2018-CHyMERA
Post-doc Fellow
Fundação Champalimaud, Portugal
 European Commission
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2010/01/01 Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)
CB06/01/0010
Researcher
Universitat Autònoma de Barcelona Departament de Bioquímica i Biologia Molecular, Spain
 Centro de Investigación Biomédica en Red Bioingeniería Biomateriales y Nanomedicina
Ongoing
Outputs

Publications

Book chapter
  1. Simões RV; Muñoz-Moreno E; Tudela R; Soria G. "1H Spectroscopic Imaging of the Rodent Brain.". In Methods in molecular biology (Clifton, N.J.). 2018.
    10.1007/978-1-4939-7531-0_12
  2. Simões, R.V.; Candiota, A.P.; Julià-Sapé, M.; Arús, C.. "In vivo magnetic resonance spectroscopic imaging and ex vivo quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy". In Methods in molecular biology (Clifton, N.J.). 2013.
    10.1007/7657_2011_31
Conference abstract
  1. Henriques, Rafael; Andrada Ianus; Shemesh, Noam; Simões, Rui V. "Correlation Tensor MRI of the mouse brain at 3 Tesla". Paper presented in 33rd Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Honolulu, 2025.
  2. Faria, Joana; Silva, Raquel; Andrada Ianus; Bettencourt Relvas, João; Simões, Rui V. Corresponding author: Simões, Rui V. "Advanced Diffusion MRI in the Mouse Brain in vivo at 3 Tesla". Paper presented in 20th European Molecular Imaging Meeting - Annual Meeting of the European Society for Molecular Imaging (ESMI), Bilbao, 2025.
    Accepted
  3. Silva, Raquel; Andrada Ianus; Faria, Joana; Henriques, Rafael; Bettencourt Relvas, João; Simões, Rui V. "Harnessing 3 Tesla MRI for advanced microstructural imaging of the mouse brain". Paper presented in 40th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), Barcelona, 2024.
    Accepted
Conference paper
  1. Ortega-Martorell, S.; Lisboa, P.J.G.; Vellido, A.; Simões, R.V.; Julià-Sapé, M.; Arús, C.. "Brain tumor pathological area delimitation through Non-negative Matrix Factorization". Paper presented in IEEE International Conference on Data Mining (ICDM): Workshop on Biological Data Mining and its Applications in Healthcare (BioDM)., Vancouver, 2011.
    Published • 10.1109/ICDMW.2011.41
Journal article
  1. Miranda, Jezid; Paules, Cristina; Noell, Guillaume; Youssef, Lina; Paternina-Caicedo, Angel; Crovetto, Francesca; Cañellas, Nicolau; et al. "Similarity network fusion to identify phenotypes of small-for-gestational-age fetuses". iScience 26 9 (2023): 107620. http://dx.doi.org/10.1016/j.isci.2023.107620.
    10.1016/j.isci.2023.107620
  2. Lina Youssef; Francesca Crovetto; Rui Vasco Simoes; Jezid Miranda; Cristina Paules; Miquel Blasco; Marta Palomo; et al. "The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics". Life (2022): https://doi.org/10.3390/life12010086.
    10.3390/life12010086
  3. Simões, R.V.; Henriques, R.N.; Cardoso, B.M.; Fernandes, F.F.; Carvalho, T.; Shemesh, N.. "Glucose fluxes in glycolytic and oxidative pathways detected in vivo by deuterium magnetic resonance spectroscopy reflect proliferation in mouse glioblastoma". NeuroImage: Clinical 33 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123426654&partnerID=MN8TOARS.
    10.1016/j.nicl.2021.102932
  4. Muñoz-Moreno, E.; Simões, R.V.; Tudela, R.; López-Gil, X.; Soria, G.. "Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer’s disease". Scientific Reports 12 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139463498&partnerID=MN8TOARS.
    10.1038/s41598-022-20962-6
  5. Gonçalves, S.I.; Simões, R.V.; Shemesh, N.. "Short TE downfield magnetic resonance spectroscopy in a mouse model of brain glioma". Magnetic Resonance in Medicine 88 2 (2022): 524-536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126761075&partnerID=MN8TOARS.
    10.1002/mrm.29243
  6. Bilreiro, Carlos; Fernandes, Francisca F.; Andrade, Luísa; Chavarrías, Cristina; Simões, Rui V.; Matos, Celso; Shemesh, Noam; et al. "Effective bowel motion reduction in mouse abdominal MRI using hyoscine butylbromide". Magnetic Resonance in Medicine 86 4 (2021): 2146-2155. https://doi.org/10.1002/mrm.28824.
    10.1002/mrm.28824
  7. Youssef, L.; Simões, R.V.; Miranda, J.; García-Martín, M.L.; Paules, C.; Crovetto, F.; Amigó, N.; et al. "Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85111095727&partnerID=MN8TOARS.
    10.1038/s41598-021-93936-9
  8. Simões, Rui. "Multicenter prospective clinical study to evaluate children short-term neurodevelopmental outcome in congenital heart disease (children NEURO-HEART): study protocol.". BMC pediatrics (2019): http://europepmc.org/articles/PMC6737686.
    10.1186/s12887-019-1689-y
  9. Rui V. Simões; Lubo Zhang; Miquel E. Cabañas; Carla Loreiro; Miriam Illa; Fatima Crispi; Eduard Gratacós. "Assessment of prenatal cerebral and cardiac metabolic changes in a rabbit model of fetal growth restriction based on 13C-labelled substrate infusions and ex vivo multinuclear HRMAS". PLOS ONE (2018): https://doi.org/10.1371/journal.pone.0208784.
    10.1371/journal.pone.0208784
  10. "Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction". Scientific Reports (2018): http://dx.doi.org/10.1038/s41598-018-31832-5.
    10.1038/s41598-018-31832-5
  11. Simões, R.V.; Veeraperumal, S.; Serganova, I.S.; Kruchevsky, N.; Varshavsky, J.; Blasberg, R.G.; Ackerstaff, E.; Koutcher, J.A.. "Inhibition of prostate cancer proliferation by Deferiprone". NMR in Biomedicine 30 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85014721481&partnerID=MN8TOARS.
    10.1002/nbm.3712
  12. Simões, R.V.; Muñoz-Moreno, E.; Cruz-Lemini, M.; Eixarch, E.; Bargalló, N.; Sanz-Cortés, M.; Gratacós, E.. "Brain metabolite alterations in infants born preterm with intrauterine growth restriction: association with structural changes and neurodevelopmental outcome". American Journal of Obstetrics and Gynecology 216 1 (2017): 62.e1-62.e14. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006804681&partnerID=MN8TOARS.
    10.1016/j.ajog.2016.09.089
  13. Cortes, M.S.; Bargallo, N.; Arranz, A.; Simoes, R.; Figueras, F.; Gratacos, E.. "Feasibility and Success Rate of a Fetal MRI and MR Spectroscopy Research Protocol Performed at Term Using a 3.0-Tesla Scanner". Fetal Diagnosis and Therapy 41 2 (2017): 127-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982273106&partnerID=MN8TOARS.
    10.1159/000445947
  14. Castells Domingo, X.; Ferrer-Font, L.; Davila, M.; Candiota, A.P.; Simões, R.V.; Fernández-Coello, A.; Gabarrós, A.; et al. "Improving Ribosomal RNA Integrity in Surgically Resected Human Brain Tumor Biopsies". Biopreservation and Biobanking 14 2 (2016): 156-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963829114&partnerID=MN8TOARS.
    10.1089/bio.2015.0086
  15. Simões, R.V.; Ortuño, J.E.; Bokacheva, L.; Candiota, A.P.; Ledesma-Carbayo, M.J.; Delgado-Goñi, T.; García-Martín, M.L.; Santos, A.; Arús, C.. "Effect of acute hyperglycemia on moderately hypothermic GL261 mouse glioma monitored by T1-weighted DCE MRI". Magnetic Resonance Materials in Physics, Biology and Medicine 28 2 (2015): 119-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939879346&partnerID=MN8TOARS.
    10.1007/s10334-014-0447-2
  16. Sanz-Cortes, M.; Egaña-Ugrinovic, G.; Simoes, R.V.; Vazquez, L.; Bargallo, N.; Gratacos, E.. "Association of brain metabolism with sulcation and corpus callosum development assessed by MRI in late-onset small fetuses". American Journal of Obstetrics and Gynecology 212 6 (2015): 804.e1-804.e8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931562980&partnerID=MN8TOARS.
    10.1016/j.ajog.2015.01.041
  17. Simões, R.V.; Serganova, I.S.; Kruchevsky, N.; Leftin, A.; Shestov, A.A.; Thaler, H.T.; Sukenick, G.; et al. "Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment". Neoplasia 17 8 (2015): 671-684. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963957265&partnerID=MN8TOARS.
    10.1016/j.neo.2015.08.005
  18. Simões, R.V.; Sanz-Cortes, M.; Muñoz-Moreno, E.; Gratacós, E.; Vázquez, É.; Bargalló, N.; Fernandez-Zubillaga, A.. "Feasibility and technical features of fetal brain magnetic resonance spectroscopy in 1.5 T scanners". American Journal of Obstetrics and Gynecology 213 5 (2015): 741-742. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946496043&partnerID=MN8TOARS.
    10.1016/j.ajog.2015.06.033
  19. Simões, R.V.; Cruz-Lemini, M.; Bargalló, N.; Gratacós, E.; Sanz-Cortés, M.. "Brain metabolite differences in one-year-old infants born small at term and association with neurodevelopmental outcome". American Journal of Obstetrics and Gynecology 213 2 (2015): 210.e1-210.e11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937967217&partnerID=MN8TOARS.
    10.1016/j.ajog.2015.04.011
  20. Simões, R.V.; Muñoz-Moreno, E.; Carbajo, R.J.; González-Tendero, A.; Illa, M.; Sanz-Cortés, M.; Pineda-Lucena, A.; Gratacós, E.. "In vivo detection of perinatal brain metabolite changes in a rabbit model of intrauterine growth restriction (IUGR)". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84941904049&partnerID=MN8TOARS.
    10.1371/journal.pone.0131310
  21. Candiota, A.P.; Acosta, M.; Simões, R.V.; Delgado-Goñi, T.; Lope-Piedrafita, S.; Irure, A.; Marradi, M.; et al. "A new ex vivo method to evaluate the performance of candidate MRI contrast agents: A proof-of-concept study". Journal of Nanobiotechnology 12 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899493271&partnerID=MN8TOARS.
    10.1186/1477-3155-12-12
  22. Sanz-Cortes, M.; Simoes, R.V.; Bargallo, N.; Masoller, N.; Figueras, F.; Gratacos, E.. "Proton magnetic resonance spectroscopy assessment of fetal brain metabolism in late-onset 'small for gestational age' versus 'intrauterine growth restriction' fetuses". Fetal Diagnosis and Therapy 37 2 (2014): 108-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924341098&partnerID=MN8TOARS.
    10.1159/000365102
  23. Ortuño, J.E.; Ledesma-Carbayo, M.J.; Simões, R.V.; Candiota, A.P.; Arús, C.; Santos, A.. "DCE@urLAB: A dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data". BMC Bioinformatics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886735382&partnerID=MN8TOARS.
    10.1186/1471-2105-14-316
  24. Delgado-Goñi, T.; Martín-Sitjar, J.; Simões, R.V.; Acosta, M.; Lope-Piedrafita, S.; Arús, C.. "Dimethyl sulfoxide (DMSO) as a potential contrast agent for brain tumors". NMR in Biomedicine 26 2 (2013): 173-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872603010&partnerID=MN8TOARS.
    10.1002/nbm.2832
  25. Ortega-Martorell, S.; Lisboa, P.J.G.; Vellido, A.; Simões, R.V.; Pumarola, M.; Julià-Sapé, M.; Arús, C.. "Convex Non-Negative Matrix Factorization for Brain Tumor Delimitation from MRSI Data". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867858795&partnerID=MN8TOARS.
    10.1371/journal.pone.0047824
  26. Simões, R.V.; Ortega-Martorell, S.; Delgado-Goñi, T.; Fur, Y.L.; Pumarola, M.; Candiota, A.P.; Martín, J.; et al. "Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSI". Integrative Biology 4 2 (2012): 183-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863049407&partnerID=MN8TOARS.
    10.1039/c2ib00079b
  27. Simões, R.V.; Delgado-Goñi, T.; Lope-Piedrafita, S.; Arús, C.. "1H-MRSI pattern perturbation in a mouse glioma: The effects of acute hyperglycemia and moderate hypothermia". NMR in Biomedicine 23 1 (2010): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149164789&partnerID=MN8TOARS.
    10.1002/nbm.1421
  28. Simões, R.V.; García-Martín, M.L.; Cerdán, S.; Arús, C.. "Perturbation of mouse glioma MRS pattern by induced acute hyperglycemia". NMR in Biomedicine 21 3 (2008): 251-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-41949133892&partnerID=MN8TOARS.
    10.1002/nbm.1188
  29. Simões, R.V.; Martinez-Aranda, A.; Martín, B.; Cerdán, S.; Sierra, A.; Arús, C.. "Preliminary characterization of an experimental breast cancer cells brain metastasis mouse model by MRI/MRS". Magnetic Resonance Materials in Physics, Biology and Medicine 21 4 (2008): 237-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249127767&partnerID=MN8TOARS.
    10.1007/s10334-008-0114-6
  30. Rodríguez, E.; Simoes, R.V.; Roig, A.; Molins, E.; Nedelko, N.; Slawska-Waniewska, A.; Aime, S.; et al. "An iron-based T1 contrast agent made of iron-phosphate complexes: in vitro and in vivo studies.". Magma (New York, N.Y.) 20 1 (2007): 27-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247892415&partnerID=MN8TOARS.
    10.1007/s10334-006-0066-7
Preprint
  1. Rui V Simões; Rafael N Henriques; Jonas L Olesen; Beatriz M Cardoso; Francisca F Fernandes; Mariana AV Monteiro; Sune N Jespersen; et al. "Deuterium Metabolic Imaging Phenotypes Mouse Glioblastoma Heterogeneity Through Glucose Turnover Kinetics". 2025. https://doi.org/10.7554/eLife.100570.2.
    10.7554/eLife.100570.2
Thesis / Dissertation
  1. Simões, Rui Vasco Portas Ferreira. "Towards molecular imaging of preclinical brain tumor models by MRS : monitoring and analysis of mouse brain glioma MR spectral pattern changes during acute hyperglycemic challenges in vivo". PhD, 2010. http://hdl.handle.net/10316/13879.

Other

Other output
  1. Effective bowel motion reduction in mouse abdominal MRI using hyoscine butylbromide. 2020. Bilreiro, C.; Fernandes, F.F.; Andrade, L.; Chavarrías, C.; Simões, R.V.; Matos, C.; Shemesh, N.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85108379028&partnerID=MN8TOARS.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/07/04 T.B.A. 5th Annual Meeting of the ISMRM Iberian Chapter
Iberian Chapter of the International Society for Magnetic Resonance in Medicine (ISMRM) (Barcelona, Spain)
2025/06/19 T.B.A. XVIII Workshop on Sensors and Molecular Recognition
Universitat Politecnica de Valencia (Valencia, Spain)
2025/03/10 Modeling the brain tumor microenvironment in glioma mouse models: metabolism, microstructure, and perfusion Modelling Minds: Innovations in Preclinical Brain Cancer Research
Net4Brain COST Action (On-Line/Virtual, Spain)
2025/01/22 AI in MRI: Where do We Stand? AI Hub
i3S - Institute for Research & Innovation in Health (Porto, Portugal)
2024/10/18 Imaging Disease Progression and Treatment Response in Rodent Models with Preclinical MRI 3R Day: Models in Biomedical Research
i3S - Institute for Research & Innovation in Health (Porto, Portugal)
2024/10/03 Lecture on Early Research Career Paths Annual Meeting of the ESMRMB
European Society for Molecular Resonance in Medicine and Biology (ESMRMB) (Barcelona, Spain)
2024/09/26 Translational Neuroimaging at i3S: from Disease Models to Patients, and Back Annual Meeting of the Portuguese Society for Neuroradiology (SPNR), Faro, Portugal (September 26-28) – mini-Symposium “Translational MRI and AI”
Portuguese Society for Neuroradiology (Faro, Portugal)
2024/09/18 In vivo Assessment of Mouse Glioblastoma: Magnetic Resonance Imaging and Spectroscopy Young Scientist Seminars
i3S - Institute for Research & Innovation in Health (Porto, Portugal)
2024/03/15 New tools to image cancer (ESMI Annual Meeting – Opening Lecture PS 29) 19th European Molecular Imaging Meeting (EMIM)
European Society for Molecular Imaging (ESMI) (Porto, Portugal)
2023/01/25 Probing glioma metabolism with MRI iBiMED/DCM Winter Seminar Series
University of Aveiro, Institute of Biomedicine, Department of Medical Sciences (Aveiro, Portugal)
2022/12/13 Preclinical MRI Lab at i3S ISMRM Iberian Chapter – Iberian Labs
ISMRM Iberian Chapter (Porto, Portugal)
2022/09/28 Preclinical MRS in glioma models (Translational imaging session “Building bridges between preclinical and clinical glioma imaging”) Glioma MRI COST Action (GliMR 2.0) – Annual Meeting 2022
GlimR 2.0 COST Action (Kusadasi, Turkey)
2020/04/20 Dynamic assessment of early metabolic perturbations in glioma-bearing mice using denoised 2H-MRS. Simões RV, Istúriz J, Olesen JL, Jerpersen SN, Shemesh N. 28th Annual Meeting of the ISMRM
ISMRM (Sydney, Australia)
2018/12/09 Preclinical MR Imaging: Mapping pre-metastatic niches using advanced DW MRI at ultrahigh field Symposium on Imaging Hallmarks of Cancer
European School of Radiology (ESOR) and Champalimaud Foundation (CF) (Lisbon, Portugal)
2017/10/11 MRS and MRSI in small animal models ESMRMB Lectures on MR 2017 – Small Animal MR Imaging
ESMRMB (Barcelona, Spain)
2017/10/09 Monitorización del metabolismo celular en modelos de enfermedad mediante espectroscopia RM multinuclear: cáncer, restricción de crecimiento fetal y enfermedad de Alzheimer Annual Meeting of the ESMRMB – Spanish Experts Session
ESMRMB (Barcelona, Spain)
2016/06/10 MR spectroscopy and spectroscopic imaging: from animal models to patients Neurosciences Institute and MR Imaging Platform Sessions
Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS)
2016/04/06 Perinatal brain metabolic profile changes associated with fetal growth restriction PhD in Biochemistry, Molecular Biology and Biomedicine - seminar series
Autonomous University of Barcelona (UAB) (Barcelona, Spain)
2015/10/12 Improving the performance of fetal brain magnetic resonance spectroscopy (MRS) at 1.5T in a multicentric study. 25th World Congress on Ultrasound in Obstetrics and Gynecology, ISUOG
ISUOG (Montreal, Canada)
2015/05/17 Brain metabolic profile changes associated with fetal growth restriction 2015 Conference Series
Andalucian Center for Nanomedicine and Biotechnology (BIONAND) (Malaga, Spain)
2014/09/14 In vivo assessment of tissue-specific metabolic changes in the fetal rabbit brain associated with intrauterine growth restriction (IUGR). 24th World Congress on Ultrasound in Obstetrics and Gynecology, International Society of Ultrasound in Obstetrics and Gynecology (ISUOG).
ISUOG (Barcelona, Spain)
2014/05/12 Simões RV, Sanz-Cortés M, Bargalló N, Figueras F, Gratacós E. Assessment of late-onset IUGR in the fetal brain using 1H-MRS. 22th Annual Meeting of the ISMRM
ISMRM (Milan, Italy)
2013/04/22 Simões RV, Kruchevsky N, Serganova I, Ackerstaff E, Sukenick G, Blasberg R, Koutcher JA. Inhibition of prostate cancer growth by deferiprone. 21th Annual Meeting of the ISMRM.
ISMRM (Salt Lake City UT, United States)
2012/07/26 Simões RV, Ackerstaff E, Serganova I, Kruchevsky N, Sukenick G, Blasberg R, Koutcher JA. 13C-MRS reveals metabolic markers of metastatic and non-metastatic phenotype in two isogenic breast cancer cell lines. The Third International Workshop on Metabolic Imaging
University of Pennsylvania (Philadelphia PA, United States)
2011/05/23 Tips for Advanced MRI Screening of Mice Annual Meeting of ISMRM – Weekday Educational Course “Mouse Imaging: how to do it faster, cheaper, & better”
ISMRM (Montreal, Canada)
2010/05/06 Simões RV, Ortega-Martorell S, Delgado-Goñi T, Pumarola M, Candiota AP, Julià-Sapé M, Arús C. Improving tumor classification with MRSI pattern perturbation. IV Annual Meeting of CIBER-BBN
CIBER-BBN (Zaragoza, Spain)
2010/03/08 Improving tumor classification with MRSI pattern perturbation CRI Annual International Symposium: “Unanswered Questions in Tumour Monitoring”
Cambridge Research Institute (Cambridge, United Kingdom)
2009/10/02 Simões RV, García-Martín ML, Delgado-Goñi T, Candiota A, Lope-Piedrafita, Pumarola M, S, Arús C. Hot-spots in mouse brain gliomas detected by MRSI pattern perturbation and DCE-MRI. 26th Annual Meeting of the ESMRMB
ESMRMB (Antalya, Turkey)
2009/04/24 Dynamics of Regional Metabolic Patterns by 1H MRSI Annual Meeting of the ISMRM – Dynamic NMR Spectroscopy Study Group.
ISMRM (Honolulu, United States)
2009/04/20 Simões RV, García-Martín ML, Delgado-Goñi T, Lope-Piedrafita S, Arús C. Unraveling mouse glioma heterogeneity with DCE-T1 MRI and 1H-CSI metabolome pattern perturbation. 17th Annual Meeting of the ISMRM
ISMRM (Honolulu HI, United States)
2009/02/17 Simões RV, García-Martín ML, Lope-Piedrafita S, Arús C. Unraveling Mouse glioma heterogeneity with DCE-T1 MRI and 1H-CSI metabolome pattern perturbation. III Annual Meeting of CIBER-BBN.
CIBER-BBN (Zaragoza, Spain)
2008/10/03 Simões RV, Lope-Piedrafita S, Arús C. Glioma metabolic heterogeneity as monitored by 1H-CSI in mice upon acute hyperglycemic challenge. 25th Annual Meeting of the ESMRMB. Valencia, SPAIN.
ESMRMB (Valencia, Spain)
2008/09/14 Simões RV, Lope-Piedrafita S, Arús C. CSI-monitored effects of acute hyperglycemia and moderate hypothermia in a glioma mouse models. ISMRM Workshop, “Frontiers of Magnetic Resonance: from tumor cell to cancer patient”
ISMRM (Nice, France)
2008/05/04 Simões RV, Cerdán S, Arús C. Towards in vivo brain tumor phenotyping with proton CSI pattern perturbation. 16th Annual Meeting of the ISMRM.
ISMRM (Toronto, Canada)
2007/05/20 Simões RV, Garcia-Martín ML, Cerdán S, Arús C. MRS pattern perturbation: a potential tool for improved brain tumor phenotyping in vivo. ISMRM Cancer Study Group – “Hot Topics Session”. ISMRM-ESMRMB Joint Annual Meeting
ISMRM (Berlin, Germany)
2006/05/07 Simões RV, Diekmann C, Cerdán S, Arús C. CSI of mouse brain tumors at 7 Tesla with 0.8µl voxel resolution. 14th Scientific Meeting and Exhibition of the ISMRM
ISMRM (Seattle, United States)
2005/09/16 Simões RV, Martinez A, Cerdán S, Sierra A, Arús C. Progression of Human Brain Metastasis in Nude Mice: Preliminary characterization by MRI/MRS. 22nd Annual Meeting of the ESMRMB
ESMRMB (Basel, Switzerland)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/02/10 - 2025/05/31 Optimized Protocol for Noise Removal in Small Animal Neuroimaging
Supervisor
 Biomedical Engineering (Degree)
Universidade do Porto Faculdade de Engenharia, Portugal
2025/02/10 - 2025/05/31 Establishing a Protocol for Spatio-temporal Quantitative Assessment of De/Re-myelination in a RhoA KO mouse model based on longitudinal MRI data
Supervisor
 Biomedical Engineering (Degree)
Universidade do Porto Faculdade de Engenharia, Portugal
2017/01/01 - 2017/07/20 MS Thesis title: Development of a tool for automatic analysis of magnetic resonance spectroscopy data: application to the study of regional and longitudinal changes of brain metabolic profile in a transgenic rat model of Alzheimer’s disease. Directors: Raúl Tudela PhD and Rui V. Simões PhD. Institution: University of Barcelona.
Supervisor
 Master in Biomedical Engineering.

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/10/03 - 2024/10/03 ESMRMB Annual Meeting – Community-initiates Symposium “Iberian MR Networks” (2024/10/03 - 2024/10/03)
Conference (President of the Organising Committee)
 European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), Austria
2024/07/02 - 2024/07/03 4th Annual Meeting of the ISMRM Iberian Chapter (Local Organizer and Program Chair) (2024/07/02 - 2024/07/03)
Congress (President of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/07/01 - 2024/07/01 Porto Translational MRI: Neuro (2024/07/01 - 2024/07/01)
Meeting (President of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/05/03 - 2023/05/05 GliMR 2.0 COST Action Annual Meeting 2024 (Local Host and Program Committee member) (2023/05/03 - 2023/05/05)
Meeting
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/09/20 - 2025/09/20 Faculty member, teaching 2 sessions on preclinical imaging during the Workshop "Mouse terful MRI"
Workshop
 20th Young European Scientist (YES) Meeting
Universidade do Porto Faculdade de Medicina, Portugal
2024/09/21 - 2024/09/22 Faculty member, teaching 3 sessions on preclinical imaging during the Workshop "Mouse terful MRI"
Workshop
 19th Young European Scientist (YES) Meeting
Universidade do Porto Faculdade de Medicina, Portugal
2022/12/15 - 2022/12/15 ISMRM Iberian Chapter – Iberian Labs: Presentation of the Preclinical MRI Lab at i3S
Meeting
 ISMRM Iberian Chapter – Iberian Labs
International Society for Magnetic Resonance in Medicine, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/09/30 NMR-based metabolomics for the identification of biomarkers of disease [https://producciocientifica.uv.es/documentos/67af954f7c83fd1196164f56]
(Thesis) Arguer
 Marina Botello Marabotto (PhD)
Universitat Politècnica de València, Spain
2016/07/20 Towards an automated analysis pipeline for MRS data: a prototype based on brain tumors". Directors: Margarida Julià-Sapé PhD, Alfredo Vellido PhD, and Carles Arús PhD. Jury: Diana Sima PhD, Dionisio Acosta PhD, and Rui V. Simões PhD
(Thesis) Arguer
 Victor Mocioiu (PhD)
Universitat Autònoma de Barcelona, Spain

Conference scientific committee

Conference name Conference host
2025/03/11 - 2025/03/14 20th European Molecular Imaging Meeting Jordi Llop
2024/09/26 - 2024/09/26 Annual Meeting of the Portuguese Society for Neuroradiology (SPNR), Faro, Portugal (September 26-28) – mini-Symposium “Translational MRI and AI” Ana Mafalda Reis
2024/07/02 - 2024/07/03 ISMRM Iberian Chapter 4th Annual Meeting Rui Simoes
2024/07/01 - 2024/07/01 Porto Translational MRI: Neuro Rui Simoes
2024/03/12 - 2024/03/15 19th European Molecular Imaging Meeting Fabian Kiessling, University of Aachen, Germany
2023/07/04 - 2023/07/05 ISMRM Iberian Chapter 3rd Annual Meeting Carlos Alberola-López, Universityy of Valladolid. Spain
2022/06/27 - 2022/06/28 ISMRM Iberian Chapter 2nd Annual Meeting Rita Nunes, Instituto Superior Técnico, Lisbon, Portugal
2021/06/16 - 2021/06/17 ISMRM Iberian Chapter 1st Annual Meeting Diego Hernando, University of Wisconsin-Madison, USA

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/10/01 - 2014/10/25 Master of Science and Healthcare of Laboratory Animals. Module 6, in vivo NMR. Autonomous University of Barcelona, Spain. 2014 Master of Science and Healthcare of Laboratory Animals (Master) Universitat Autònoma de Barcelona Facultat de Veterinària, Spain
2008/10/01 - 2008/10/25 Master of Science and Healthcare of Laboratory Animals. Module 6, in vivo NMR. Autonomous University of Barcelona, Spain. Master of Science and Healthcare of Laboratory Animals (Master) Universitat Autònoma de Barcelona Facultat de Veterinària, Spain

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2023/09/04 Preclinical MRI for translational imaging at i3S (Article in i3S Newsletter) i3S Newsletter #96

Mentoring / Tutoring

Topic Student name
2025/06/02 - 2025/06/05 ISMRM Iberian Chapter Mobility Action Balbino Yague
2025/02/03 - 2025/02/12 CIBER Mobility Action Ana Paula Candiota
2024/09/06 - 2024/09/06 Porto Summer Academy Ana Beatriz Castro Santos
2024/07/01 - 2024/08/31 Summer internship: Preclinical MRI of mouse models Maria Lima
2016/05/01 - 2019/12/01 Erasmus Mundus Doctorate in Fetal and Perinatal Medicine Lina Youssef
Distinctions

Award

2023 GliMR 2.0 Researcher of the month
2018 Seal of Excellence Certificate: H2020-MSCA-IF-2017
European Commission, Belgium
2017 Front cover (Simões et al. AJOG 2017: issue 1, January)
2017 Best abstract award: International Symposium on Diabetes, Hypertension, Metabolic Syndrome & Pregnancy. Barcelona, Spain.
2015 Best short oral presentation award. ISUOG Meeting. Montreal, CANADA.
2015 Featured Article (http://www.ajog.org/featured)
2014 summa cum laude award for Oral Talk. Joint Annual Meeting ISMRM-ESMRMB. Milan, ITALY.
International Society for Magnetic Resonance in Medicine, United States
2013 Abstract award. ISMRM 21th Meeting. Salt Lake City UT, USA.
2012 Student award for Oral Presentation. Philadelphia PA, USA.
2012 Scholar-in-training grantee award. San Antonio TX, USA.
2009 Student support program. ESMRMB 26th Scientific Meeting & Exhibition, Antalya, Turkey
2008 Educational stipend. ISMRM 16th Scientific Meeting & Exhibition, Toronto/Canada.
International Society for Magnetic Resonance in Medicine, United States
2007 Educational stipend. Joint Annual Meeting ISMRM-ESMRMB, Berlin/Germany.
International Society for Magnetic Resonance in Medicine, United States
2006 Educational stipend. ISMRM 14th Scientific Meeting & Exhibition, Seattle/USA.
International Society for Magnetic Resonance in Medicine, United States
2005 PhD Grant
2005 Student support program. ESMRMB 22nd Meeting, Basle/Switzerland
2004 Beca de Formación de Personal Investigador
2003 Beca de Formació i Suport a la Investigació, projecte MEDIVO
2002 Under-graduate internship grant, PRODEP III

Title

2024 Executive and Management Board (EMB) Member, Glioma MRI Work Group
European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), Austria
2024 Preclinical MRI Task Force Co-Leader, Glioma MRI Work Group
European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), Austria
2020 Secretary Elected: ISMRM Iberian Chapter
International Society for Magnetic Resonance in Medicine, United States

Other distinction

2017 Certification: ParaVision 6/7 Programming Course (PPC)
Bruker BioSpin MRI GmbH, Germany
2016 Certification: Good Clinical Practice for Researchers (GCP)
Hospital Clínic de Barcelona, Spain
2003 Execution and Conception of Animal Procedures (License A and B)
Universitat Autònoma de Barcelona, Spain