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Jeremy C Simpson. Published 19 articles in journals. Has 1 book(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: membrane traffic; high-content screening (HCS) microscopy ; high-content analysis (HCA); Rab GTPases; RNAi screening; endomembrane system; spheroids; nanoparticles; endocytosis; secretory pathway; .
Identification

Personal identification

Full name
Jeremy C Simpson

Citation names

  • Simpson, Jeremy C

Author identifiers

Ciência ID
2F12-4AFA-181E
ORCID iD
0000-0002-7956-7805

Addresses

  • UCD School of Biology & Environmental Science, D4, Dublin, Dublin, Ireland (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
Education
Degree Classification
1992/09 - 1995/12
Concluded
 Biochemistry / Cell Biology (Doktor (PhD))
University of Warwick, United Kingdom
"The Intracellular Transport and Translocation of Ricin" (THESIS/DISSERTATION)
1988/09 - 1992/06
Concluded
 Microbiology & Microbial Technology (Bachelor)
University of Warwick, United Kingdom
 First class
Affiliation

Science

Category
Host institution 		Employer
2008/05/01 - Current Principal Investigator (Research) University College Dublin, Ireland
2001/06/01 - 2008/12/31 Researcher (Research) European Molecular Biology Laboratory, Italy
1999/06/01 - 2001/05/31 Researcher (Research) European Molecular Biology Laboratory, Germany
1996/01/01 - 1999/05/31 Postdoc (Research) University of Warwick, United Kingdom

Positions / Appointments

Category
Host institution 		Employer
2011/12 - Current Vice Principal (International) University College Dublin, Ireland
University College Dublin College of Science, Ireland
2014/01 - 2019/08 Head of School University College Dublin, Ireland
University College Dublin School of Biology and Environmental Science, Ireland
Projects

Contract

Designation Funders
2015/01/01 - 2021/01/01 Medical Devices For Buccal Delivery Of Bioactive Drugs: An SFI Curam Core Project
SFI2015
Principal investigator
University College Dublin, Ireland
 Science Foundation Ireland
Ongoing
2017/04/01 - 2020/03/31 Elucidating The Mechanisms And Pathways Of Extracellular Vesicle Uptake And Intercellular Stress Response
BBSRC-SFI2017
Principal investigator
Science Foundation Ireland
Ongoing
2017/01/01 - 2017/12/31 An Advanced High-Throughput Imaging Platform For Multi- Dimensional Analysis Of Complex Biological Models In Health And Disease
SFI2017
Principal investigator
University College Dublin, Ireland
 Science Foundation Ireland
Concluded
2013/10/01 - 2016/09/30 Investigating the Role of The Actin Cytoskeleton in the Early Secretory Pathway
IRC2013
Supervisor
University College Dublin, Ireland
 Irish Research Council
Concluded
2010/03/01 - 2016/02/29 Dissecting plasma membrane to endoplasmic reticulum trafficking pathways in mammalian cells – potential new avenues for improved drug delivery
09/IN.1/B2604
Principal investigator
Science Foundation Ireland
Concluded

Other

Designation Funders
2019/09/01 - 2023/08/31 Molecular Dissection Of The Mechanisms Of Nanoparticle Penetrance Into 3D Cancer Cell Models
IRC2019-1
Supervisor
Irish Research Council
Ongoing
2019/09/01 - 2023/08/31 Towards A Molecular Understanding Of The Role Of Rab33b In Hereditary Skeletal Dysplasia
IRC2019-2
Supervisor
Irish Research Council
Ongoing
2014/10/06 - 2018/09/30 Investigation Of The Cellular Uptake Of Functionalised Carbon Nanoparticles
RESA2014
Supervisor
University College Dublin, Ireland
Concluded
2014/10/01 - 2018/09/30 Molecular Characterisation of the Cellular Role of Rab33B in Healthy and Diseased Cells
IRC2014
Supervisor
University College Dublin, Ireland
 Irish Research Council
Concluded
2012/09/01 - 2015/08/31 Elucidating The Molecular Machinery Of The Rab6-Dependent Retrograde Pathway
IRC2012
Supervisor
University College Dublin, Ireland
 Irish Research Council
Concluded
Outputs

Publications

Book
  1. Galea, G.; Simpson, J.C.. High-content screening and analysis of the golgi complex. 2013.
    10.1016/B978-0-12-417164-0.00017-3
  2. Pepperkok, R.; Simpson, J.C.; Rietdorf, J.; Cetin, C.; Liebel, U.; Terjung, S.; Zimmermann, T.. Imaging platforms for measurement of membrane trafficking. 2006.
    10.1016/S0076-6879(05)04002-4
  3. Simpson, J.C.; Pepperkok, R.. Systematic Subcellular Localization of Novel Proteins. 2006.
    10.1016/B978-012164730-8/50140-4
  4. Simpson, J.C.; Jones, A.T.. Early endocytic Rabs: Functional prediction to functional characterization. 2005.
Conference paper
  1. Rietdorf, Jens; Stephens, David J.; Squire, Anthony; Simpson, Jeremy; Shima, David T.; Paccaud, Jean-Pierre; Bastiaens, Philippe I.H.; Pepperkok, Rainer. "Illuminating cellular structure and function in the early secretory pathway by multispectral 3D imaging in living cells". 2000.
Journal article
  1. Jeremy C. Simpson. "Modification of the Mammalian Endomembrane System in Healthy and Diseased Cells". International Journal of Molecular Sciences 21 6 (2020): 2133-2133. https://doi.org/10.3390/ijms21062133.
    10.3390/ijms21062133
  2. Silke Morris; Niall D. Geoghegan; Jessica B.A. Sadler; Anna M. Koester; Hannah L. Black; Marco Laub; Lucy Miller; et al. "Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes". PeerJ (2020): https://doi.org/10.7717/peerj.8751.
    10.7717/peerj.8751
  3. Matthew V. X. Whelan; Laura Ardill; Kentaro Koide; Chie Nakajima; Yasuhiko Suzuki; Jeremy C. Simpson; Tadhg Ó Cróinín. "Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-54620-1.
    10.1038/s41598-019-54620-1
  4. Meritxell B. Cutrona; Jeremy C. Simpson. "A High-Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids". Small (2019): 1902033-1902033. https://doi.org/10.1002/smll.201902033.
    10.1002/smll.201902033
  5. Niamh E. Morgan; Meritxell B. Cutrona; Jeremy C. Simpson. "Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b". International Journal of Molecular Sciences 20 16 (2019): 3916-3916. https://doi.org/10.3390/ijms20163916.
    10.3390/ijms20163916
  6. Kevin T. O’Brien; Surajit Bhattacharjya; Kalyan Golla; Tilen Kranjc; Darragh O’Donovan; Seamus Allen; Patricia Maguire; et al. "Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome". PLOS ONE (2019): https://doi.org/10.1371/journal.pone.0210337.
    10.1371/journal.pone.0210337
  7. Stephen J. Devereux; Marina Massaro; Andrew Barker; David T. Hinds; Badriah Hifni; Jeremy C. Simpson; Susan J. Quinn. "Spectroscopic study of the loading of cationic porphyrins by carbon nanohorns as high capacity carriers of photoactive molecules to cells". Journal of Materials Chemistry B (2019): https://doi.org/10.1039/C9TB00217K.
    10.1039/C9TB00217K
  8. Tilen Kranjc; Eugene Dempsey; Gerard Cagney; Nobuhiro Nakamura; Denis C. Shields; Jeremy C. Simpson. "Functional characterisation of the YIPF protein family in mammalian cells". Histochemistry and Cell Biology (2017): https://doi.org/10.1007%2Fs00418-016-1527-3.
    10.1007/s00418-016-1527-3
  9. Maeve Long; Jeremy C. Simpson. "Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology". Tissue and Cell (2017): http://dx.doi.org/10.1016/j.tice.2016.09.007.
    10.1016/j.tice.2016.09.007
  10. Amy Lyden; Lisa Lombardi; Wilfried Sire; Peng Li; Jeremy C. Simpson; Geraldine Butler; Gil U. Lee. "Characterization of carboxylate nanoparticle adhesion with the fungal pathogen Candida albicans". Nanoscale 9 41 (2017): 15911-15922. https://doi.org/10.1039/C7NR04724J.
    10.1039/C7NR04724J
  11. Varela, J.A.; Åberg, C.; Simpson, J.C.; Dawson, K.A.. "Trajectory-Based Co-Localization Measures for Nanoparticle-Cell Interaction Studies". Small 11 17 (2015): 2026-2031. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928801800&partnerID=MN8TOARS.
    10.1002/smll.201401849
  12. Higa, A.; Taouji, S.; Lhomond, S.; Jensen, D.; Fernandez-Zapico, M.E.; Simpson, J.C.; Pasquet, J.-M.; Schekman, R.; Chevet, E.. "Endoplasmic reticulum stress-activated transcription factor ATF6a requires the disulfide isomerase PDIA5 to modulate chemoresistance". Molecular and Cellular Biology 34 10 (2014): 1839-1849. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899139079&partnerID=MN8TOARS.
    10.1128/MCB.01484-13
  13. Michel, G.; Matthes, H.W.D.; Hachet-Haas, M.; El Baghdadi, K.; de Mey, J.; Pepperkok, R.; Simpson, J.C.; Galzi, K.-L.; Lecat, S.. "Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation". Journal of Cell Science 127 4 (2014): 773-787. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894031924&partnerID=MN8TOARS.
    10.1242/jcs.136432
  14. Bexiga, M.G.; Kelly, C.; Dawson, K.A.; Simpson, J.C.. "RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells". Nanomedicine 9 11 (2014): 1651-1664. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908880951&partnerID=MN8TOARS.
    10.2217/nnm.13.151
  15. Farrell, J.; Kelly, C.; Rauch, J.; Kida, K.; García-Muñoz, A.; Monsefi, N.; Turriziani, B.; et al. "HGF induces epithelial-to-mesenchymal transition by modulating the mammalian Hippo/MST2 and ISG15 pathways". Journal of Proteome Research 13 6 (2014): 2874-2886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902077145&partnerID=MN8TOARS.
    10.1021/pr5000285
  16. Sauvageau, E.; Rochdi, M.D.; Oueslati, M.; Hamdan, F.F.; Percherancier, Y.; Simpson, J.C.; Pepperkok, R.; Bouvier, M.. "CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum". Traffic 15 4 (2014): 383-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896764696&partnerID=MN8TOARS.
    10.1111/tra.12148
  17. Heffernan, L.F.; Simpson, J.C.. "The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport". Biochemical Society Transactions 42 (2014): 1453-1459. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907192657&partnerID=MN8TOARS.
    10.1042/BST20140178
  18. McCarthy, J.M.; Franke, M.; Resenberger, U.K.; Waldron, S.; Simpson, J.C.; Tatzelt, J.; Appelhans, D.; Rogers, M.S.. "Anti-Prion Drug mPPIg5 Inhibits PrPC Conversion to PrPSc". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873848887&partnerID=MN8TOARS.
    10.1371/journal.pone.0055282
  19. Stadler, C.; Rexhepaj, E.; Singan, V.R.; Murphy, R.F.; Pepperkok, R.; Uhlén, M.; Simpson, J.C.; Lundberg, E.. "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells". Nature Methods 10 4 (2013): 315-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875701652&partnerID=MN8TOARS.
    10.1038/nmeth.2377
  20. Miranda-CasoLuengo, A.A.; Miranda-CasoLuengo, R.; Lieggi, N.T.; Luo, H.; Simpson, J.C.; Meijer, W.G.. "A Real-Time Impedance Based Method to Assess Rhodococcus equi Virulence". PLoS ONE 8 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875506714&partnerID=MN8TOARS.
    10.1371/journal.pone.0060612
  21. Wang, F.; Bexiga, M.G.; Anguissola, S.; Boya, P.; Simpson, J.C.; Salvati, A.; Dawson, K.A.. "Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles". Nanoscale 5 22 (2013): 10868-10876. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886682963&partnerID=MN8TOARS.
    10.1039/c3nr03249c
  22. Bexiga, M.G.; Simpson, J.C.. "Human diseases associated with form and function of the Golgi complex". International Journal of Molecular Sciences 14 9 (2013): 18670-18681. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884192614&partnerID=MN8TOARS.
    10.3390/ijms140918670
  23. Singan, V.R.; Handzic, K.; Curran, K.M.; Simpson, J.C.. "A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients". BMC Research Notes 5 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861947787&partnerID=MN8TOARS.
    10.1186/1756-0500-5-281
  24. Sandin, P.; Fitzpatrick, L.W.; Simpson, J.C.; Dawson, K.A.. "High-speed imaging of rab family small GTpases reveals rare events in nanoparticle trafficking in living cells". ACS Nano 6 2 (2012): 1513-1521. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857714396&partnerID=MN8TOARS.
    10.1021/nn204448x
  25. Roth, S.D.; Schüttrumpf, J.; Milanov, P.; Abriss, D.; Ungerer, C.; Quade-Lyssy, P.; Simpson, J.C.; et al. "Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A". PLoS ONE 7 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866043687&partnerID=MN8TOARS.
    10.1371/journal.pone.0044505
  26. Simpson, J.C.; Joggerst, B.; Laketa, V.; Verissimo, F.; Cetin, C.; Erfle, H.; Bexiga, M.G.; et al. "Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway". Nature Cell Biology 14 7 (2012): 764-774. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863205689&partnerID=MN8TOARS.
    10.1038/ncb2510
  27. Singan, V.R.; Handzic, K.; Simpson, J.C.. "Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells". Biochemical Society Transactions 40 6 (2012): 1389-1393. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870155302&partnerID=MN8TOARS.
    10.1042/BST20120145
  28. Varela, J.A.; Bexiga, M.G.; Åberg, C.; Simpson, J.C.; Dawson, K.A.. "Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells". Journal of Nanobiotechnology 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866517033&partnerID=MN8TOARS.
    10.1186/1477-3155-10-39
  29. Yi, P.; Higa, A.; Taouji, S.; Bexiga, M.G.; Marza, E.; Arma, D.; Castain, C.; et al. "Sorafenib-mediated targeting of the AAA+ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death". Molecular Cancer Therapeutics 11 12 (2012): 2610-2620. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871382622&partnerID=MN8TOARS.
    10.1158/1535-7163.MCT-12-0516
  30. Tängemo, C.; Ronchi, P.; Colombelli, J.; Haselmann, U.; Simpson, J.C.; Antony, C.; Stelzer, E.H.K.; Pepperkok, R.; Reynaud, E.G.. "A novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells". Journal of Cell Science 124 6 (2011): 978-987. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952811199&partnerID=MN8TOARS.
    10.1242/jcs.079640
  31. Moore, H.M.; Bai, B.; Boisvert, F.-M.; Latonen, L.; Rantanen, V.; Simpson, J.C.; Pepperkok, R.; Lamond, A.I.; Laiho, M.. "Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation". Molecular and Cellular Proteomics 10 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80054043851&partnerID=MN8TOARS.
    10.1074/mcp.M111.009241
  32. Moore, H.M.; Bai, B.; Boisvert, F.M.; Latonen, L.; Rantanen, V.; Simpson, J.C.; Pepperkok, R.; Lamond, A.I.; Laiho, M.. "Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.". Molecular & cellular proteomics : MCP 10 10 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856455055&partnerID=MN8TOARS.
  33. Bexiga, M.G.; Varela, J.A.; Wang, F.; Fenaroli, F.; Salvati, A.; Lynch, I.; Simpson, J.C.; Dawson, K.A.. "Cationic nanoparticles induce caspase 3-, 7-and 9-mediated cytotoxicity in a human astrocytoma cell line". Nanotoxicology 5 4 (2011): 557-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-80655125242&partnerID=MN8TOARS.
    10.3109/17435390.2010.539713
  34. Singan, V.R.; Jones, T.R.; Curran, K.M.; Simpson, J.C.. "Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images". BMC Bioinformatics 12 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80054752054&partnerID=MN8TOARS.
    10.1186/1471-2105-12-407
  35. Burgo, A.; Sotirakis, E.; Simmler, M.-C.; Verraes, A.; Chamot, C.; Simpson, J.C.; Lanzetti, L.; Proux-Gillardeaux, V.; Galli, T.. "Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth". EMBO Reports 10 10 (2009): 1117-1124. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449704085&partnerID=MN8TOARS.
    10.1038/embor.2009.186
  36. Martinez-Morales, J.R.; Rembold, M.; Greger, K.; Simpson, J.C.; Brown, K.E.; Quiring, R.; Pepperkok, R.; et al. "Ojoplano-mediated basal constriction is essential for optic cup morphogenesis". Development 136 13 (2009): 2165-2175. http://www.scopus.com/inward/record.url?eid=2-s2.0-69549110656&partnerID=MN8TOARS.
    10.1242/dev.033563
  37. Heinz, S.; Schüttrumpf, J.; Simpson, J.C.; Pepperkok, R.; Nicolaes, G.A.; Abriss, D.; Milanov, P.; et al. "Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII". Thrombosis and Haemostasis 102 5 (2009): 925-935. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449565560&partnerID=MN8TOARS.
    10.1160/TH08-12-0807
  38. Simpson, J.C.. "Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway". Seminars in Cell and Developmental Biology 20 8 (2009): 903-909. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449094672&partnerID=MN8TOARS.
    10.1016/j.semcdb.2009.07.005
  39. Simpson, J.C.; Wellenreuther, R.; Poustka, A.; Pepperkok, R.; Wiemann, S.. "Erratum: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing (EMBO reports (2000) 1 (287-292) DOI: 10.1093/embo-reports/kvd058)". EMBO Reports 10 12 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-73849091601&partnerID=MN8TOARS.
    10.1038/embor.2009.245
  40. Tsai, Y.-S.; Chung, I.-F.; Simpson, J.C.; Lee, M.-I.; Hsiung, C.-C.; Chiu, T.-Y.; Kao, L.-S.; et al. "Automated recognition system to classify subcellular protein localizations in images of different cell lines acquired by different imaging systems". Microscopy Research and Technique 71 4 (2008): 305-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049114520&partnerID=MN8TOARS.
    10.1002/jemt.20555
  41. Fladeby, C.; Gupta, S.N.; Barois, N.; Lorenzo, P.I.; Simpson, J.C.; Saatcioglu, F.; Bakke, O.. "Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells". International Journal of Cancer 122 6 (2008): 1229-1235. http://www.scopus.com/inward/record.url?eid=2-s2.0-39649095155&partnerID=MN8TOARS.
    10.1002/ijc.23185
  42. Dejgaard, S.Y.; Murshid, A.; Erman, A.; Kizilay, Ö.; Verbich, D.; Lodge, R.; Dejgaard, K.; et al. "Rab18 and Rab43 have key roles in ER-Golgi trafficking". Journal of Cell Science 121 16 (2008): 2768-2781. http://www.scopus.com/inward/record.url?eid=2-s2.0-52649178960&partnerID=MN8TOARS.
    10.1242/jcs.021808
  43. Schallus, T.; Jaeckh, C.; Fehér, K.; Palma, A.S.; Liu, Y.; Simpson, J.C.; Mackeen, M.; et al. "Malectin: A novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation". Molecular Biology of the Cell 19 8 (2008): 3404-3414. http://www.scopus.com/inward/record.url?eid=2-s2.0-54249136020&partnerID=MN8TOARS.
    10.1091/mbc.E08-04-0354
  44. Simpson, J.C.; Cetin, C.; Erfle, H.; Joggerst, B.; Liebel, U.; Ellenberg, J.; Pepperkok, R.. "An RNAi screening platform to identify secretion machinery in mammalian cells". Journal of Biotechnology 129 2 (2007): 352-365. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047171306&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2006.12.027
  45. Laketa, V.; Simpson, J.C.; Bechtel, S.; Wiemann, S.; Pepperkok, R.. "High-content microscopy identifies new neurite outgrowth regulators". Molecular Biology of the Cell 18 1 (2007): 242-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846048340&partnerID=MN8TOARS.
    10.1091/mbc.E06-08-0666
  46. von Brunn, A.; Teepe, C.; Simpson, J.C.; Pepperkok, R.; Friedel, C.C.; Zimmer, R.; Roberts, R.; Baric, R.; Haas, J.. "Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome". PLoS ONE 2 5 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-35148862429&partnerID=MN8TOARS.
    10.1371/journal.pone.0000459
  47. Simpson, J.C.; Mateos, A.; Pepperkok, R.. "Maturation of the mammalian secretome". Genome Biology 8 4 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-35748943215&partnerID=MN8TOARS.
    10.1186/gb-2007-8-4-211
  48. Lin, C.-C.; Tsai, Y.-S.; Lin, Y.-S.; Chiu, T.-Y.; Hsiung, C.-C.; Lee, M.-I.; Simpson, J.C.; Hsu, C.-N.. "Boosting multiclass learning with repeating codes and weak detectors for protein subcellular localization". Bioinformatics 23 24 (2007): 3374-3381. http://www.scopus.com/inward/record.url?eid=2-s2.0-36949037952&partnerID=MN8TOARS.
    10.1093/bioinformatics/btm497
  49. Wessels, E.; Simpson, J.C.. "Impact of live cell imaging on coated vesicle research". Seminars in Cell and Developmental Biology 18 4 (2007): 412-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548419828&partnerID=MN8TOARS.
    10.1016/j.semcdb.2007.07.002
  50. Mehrle, A.; Rosenfelder, H.; Schupp, I.; del Val, C.; Arlt, D.; Hahne, F.; Bechtel, S.; et al. "The LIFEdb database in 2006.". Nucleic acids research. 34 Database i (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33644877441&partnerID=MN8TOARS.
  51. Al-Taei, S.; Penning, N.A.; Simpson, J.C.; Futaki, S.; Takeuchi, T.; Nakase, I.; Jones, A.T.. "Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors". Bioconjugate Chemistry 17 1 (2006): 90-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-31544479580&partnerID=MN8TOARS.
    10.1021/bc050274h
  52. Kolb-Kokocinski, A.; Mehrle, A.; Bechtel, S.; Simpson, J.C.; Kioschis, P.; Weimann, S.; Wellenreuther, R.; Poustka, A.. "The systematic functional characterisation of Xq28 genes prioritises candidate disease genes". BMC Genomics 7 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33645554587&partnerID=MN8TOARS.
    10.1186/1471-2164-7-29
  53. Simpson, J.C.; Nilsson, T.; Pepperkok, R.. "Biogenesis of tubular ER-to-golgi transport intermediates". Molecular Biology of the Cell 17 2 (2006): 723-737. http://www.scopus.com/inward/record.url?eid=2-s2.0-31944449219&partnerID=MN8TOARS.
    10.1091/mbc.E05-06-0580
  54. Stertz, S.; Reichelt, M.; Krijnse-Locker, J.; Mackenzie, J.; Simpson, J.C.; Haller, O.; Kochs, G.. "Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum". Journal of Interferon and Cytokine Research 26 9 (2006): 650-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750615869&partnerID=MN8TOARS.
    10.1089/jir.2006.26.650
  55. Simpson, J.C.; Pepperkok, R.. "The subcellular localization of the mammalian proteome comes a fraction closer". Genome Biology 7 6 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33750104230&partnerID=MN8TOARS.
    10.1186/gb-2006-7-6-222
  56. Stauber, T.; Simpson, J.C.; Pepperkok, R.; Vernos, I.. "A Role for Kinesin-2 in COPI-Dependent Recycling between the ER and the Golgi Complex". Current Biology 16 22 (2006): 2245-2251. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750932783&partnerID=MN8TOARS.
    10.1016/j.cub.2006.09.060
  57. Neubrand, V.E.; Will, R.D.; Möbius, W.; Poustka, A.; Wiemann, S.; Schu, P.; Dotti, C.G.; Pepperkok, R.; Simpson, J.C.. "¿-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO Journal 24 6 (2005): 1122-1133. http://www.scopus.com/inward/record.url?eid=2-s2.0-17144388940&partnerID=MN8TOARS.
    10.1038/sj.emboj.7600600
  58. Welsch, T.; Endlich, N.; Gökce, G.; Doroshenko, E.; Simpson, J.C.; Kriz, W.; Shaw, A.S.; Endlich, K.. "Association of CD2AP with dynamic actin on vesicles in podocytes". American Journal of Physiology - Renal Physiology 289 5 58-5 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-26844439600&partnerID=MN8TOARS.
    10.1152/ajprenal.00178.2005
  59. Arlt, D.; Huber, W.; Liebel, U.; Schmidt, C.; Majety, M.; Sauermann, M.; Rosenfelder, H.; et al. "Functional profiling: From microarrays via cell-based assays to novel tumor relevant modulators of the cell cycle". Cancer Research 65 17 (2005): 7733-7742. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744471663&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-05-0642
  60. Schmidt, M.; Gerlach, F.; Avivi, A.; Laufs, T.; Wystub, S.; Simpson, J.C.; Nevo, E.; et al. "Cytoglobin Is a Respiratory Protein in Connective Tissue and Neurons, Which Is Up-regulated by Hypoxia". Journal of Biological Chemistry 279 9 (2004): 8063-8069. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744220623&partnerID=MN8TOARS.
    10.1074/jbc.M310540200
  61. Schlickum, S.; Moghekar, A.; Simpson, J.C.; Steglich, C.; O'Brien, R.J.; Winterpacht, A.; Endele, S.U.. "LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein". Genomics 83 2 (2004): 254-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347359154&partnerID=MN8TOARS.
    10.1016/j.ygeno.2003.08.013
  62. Erfle, H.; Simpson, J.C.; Bastiaens, P.I.H.; Pepperkok, R.. "siRNA cell arrays for high-content screening microscopy". BioTechniques 37 3 (2004): 454-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444290116&partnerID=MN8TOARS.
  63. Becker, S.; Simpson, J.C.; Pepperkok, R.; Heinz, S.; Herder, C.; Grez, M.; Seifried, E.; Tonn, T.. "Confocal microscopy analysis of native, full length and B-domain deleted coagulation factor VIII trafficking in mammalian cells". Thrombosis and Haemostasis 92 1 (2004): 23-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-3543036376&partnerID=MN8TOARS.
  64. Nakase, I.; Niwa, M.; Takeuchi, T.; Sonomura, K.; Kawabata, N.; Koike, Y.; Takehashi, M.; et al. "Cellular uptake of arginine-rich peptides: Roles for macropinocytosis and actin rearrangement". Molecular Therapy 10 6 (2004): 1011-1022. http://www.scopus.com/inward/record.url?eid=2-s2.0-10344221003&partnerID=MN8TOARS.
    10.1016/j.ymthe.2004.08.010
  65. Starkuviene, V.; Liebel, U.; Simpson, J.C.; Erfle, H.; Poustka, A.; Wiemann, S.; Pepperkok, R.. "High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic". Genome Research 14 10 A (2004): 1948-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-6344222240&partnerID=MN8TOARS.
    10.1101/gr.2658304
  66. Simpson, J.C.; Griffiths, G.; Wessling-Resnick, M.; Fransen, J.A.M.; Bennett, H.; Jones, A.T.. "A role for the small GTPase Rab21 in the early endocytic pathway". Journal of Cell Science 117 26 (2004): 6297-6311. http://www.scopus.com/inward/record.url?eid=2-s2.0-13444254076&partnerID=MN8TOARS.
    10.1242/jcs.01560
  67. Elsner, M.; Hashimoto, H.; Simpson, J.C.; Cassel, D.; Nilsson, T.; Weiss, M.. "Spatiotemporal dynamics of the COPI vesicle machinery". EMBO Reports 4 10 (2003): 1000-1005. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242439330&partnerID=MN8TOARS.
    10.1038/sj.embor.embor942
  68. Simpson, J.C.; Pepperkok, R.. "Localizing the proteome". Genome Biology 4 12 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0345865040&partnerID=MN8TOARS.
    10.1186/gb-2003-4-12-240
  69. Liebel, U.; Starkuviene, V.; Erfle, H.; Simpson, J.C.; Poustka, A.; Wiemann, S.; Pepperkok, R.. "A microscope-based screening platform for large-scale functional protein analysis in intact cells". FEBS Letters 554 3 (2003): 394-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242458219&partnerID=MN8TOARS.
    10.1016/S0014-5793(03)01197-9
  70. Reynaud, E.G.; Simpson, J.C.. "Navigating the secretory pathway. Conference on exocytosis membrane structure and dynamics". EMBO Reports 3 9 (2002): 828-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036747341&partnerID=MN8TOARS.
    10.1093/embo-reports/kvf185
  71. Brown, W.L.; Mastico, R.A.; Wu, M.; Heal, K.G.; Adams, C.J.; Murray, J.B.; Simpson, J.C.; et al. "RNA bacteriophage capsid-mediated drug delivery and epitope presentation". Intervirology 45 4-6 (2002): 371-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036980063&partnerID=MN8TOARS.
    10.1159/000067930
  72. Pepperkok, R.; Simpson, J.C.; Wiemann, S.. "Being in the right location at the right time". Genome Biology 2 9 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034806512&partnerID=MN8TOARS.
  73. Simpson, J.C.; Neubrand, V.E.; Wiemann, S.; Pepperkok, R.. "Illuminating the human genome". Histochemistry and Cell Biology 115 1 (2001): 23-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035098929&partnerID=MN8TOARS.
  74. Kerkhoff, E.; Simpson, J.C.; Leberfinger, C.B.; Otto, I.M.; Doerks, T.; Bork, P.; Rapp, U.R.; Raabe, T.; Pepperkok, R.. "The Spir actin organizers are involved in vesicle transport processes". Current Biology 11 24 (2001): 1963-1968. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035846602&partnerID=MN8TOARS.
    10.1016/S0960-9822(01)00602-9
  75. Simpson, J.C.; Wellenreuther, R.; Poustka, A.; Pepperkok, R.; Wiemann, S.. "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 3 (2000): 287-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034280113&partnerID=MN8TOARS.
  76. Jackson, M.E.; Simpson, J.C.; Girod, A.; Pepperkok, R.; Roberts, L.M.; Lord, J.M.. "The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum". Journal of Cell Science 112 4 (1999): 467-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032969203&partnerID=MN8TOARS.
  77. Girod, A.; Storrie, B.; Simpson, J.C.; Johannes, L.; Goud, B.; Roberts, L.M.; Lord, J.M.; Nilsson, T.; Pepperkok, R.. "Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum". Nature Cell Biology 1 7 (1999): 423-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033224214&partnerID=MN8TOARS.
  78. Simpson, J.C.; Roberts, L.M.; Römisch, K.; Davey, J.; Wolf, D.H.; Lord, J.M.. "Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast". FEBS Letters 459 1 (1999): 80-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032879634&partnerID=MN8TOARS.
    10.1016/S0014-5793(99)01222-3
  79. Simpson, J.C.; Smith, D.C.; Roberts, L.M.; Lord, J.M.. "Expression of mutant dynamin protects cells against diphtheria toxin but not against ricin". Experimental Cell Research 239 2 (1998): 293-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031868419&partnerID=MN8TOARS.
    10.1006/excr.1997.3921
  80. Simpson, J.C.; Roberts, L.M.; Lord, J.M.. "Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol". Experimental Cell Research 229 2 (1996): 447-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030589643&partnerID=MN8TOARS.
    10.1006/excr.1996.0390
  81. Simpson, J.C.; Lord, J.M.; Roberts, L.M.. "Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocation". European Journal of Biochemistry 232 2 (1995): 458-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029088942&partnerID=MN8TOARS.
    10.1111/j.1432-1033.1995.tb20831.x
  82. Simpson, J.C.; Dascher, C.; Roberts, L.M.; Lord, J.M.; Balch, W.E.. "Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex". Journal of Biological Chemistry 270 34 (1995): 20078-20083. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029147513&partnerID=MN8TOARS.
    10.1074/jbc.270.34.20078
  83. Simpson, J.C.; Roberts, L.M.; Lord, J.M.. "Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus". Protein Expression and Purification 6 5 (1995): 665-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029379790&partnerID=MN8TOARS.
    10.1006/prep.1995.1087
Distinctions

Title

2014 Head of School
University College Dublin School of Biology and Environmental Science, Ireland
2011 Vice-Principal (International)
University College Dublin College of Science, Ireland

Other distinction

2012 Head of Subject, Cell and Molecular Biology
University College Dublin, Ireland