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Sylvain Ladame. Published 8 articles in journals. Works in the area(s) of Engineering and Technology with emphasis on Medical Engineering. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: nucleic acids; biosensor; fluorescence; peptide nucleic acid; molecular targeting; therapeutic; diagnostics; .
Identification

Personal identification

Full name
Sylvain Ladame

Citation names

  • Ladame, Sylvain

Author identifiers

Ciência ID
2F16-ABED-669E
ORCID iD
0000-0002-3358-9638

Telephones

Telephone
  • (+44) 0207594530 (Professional)

Addresses

  • Imperial College London, Department of Bioengineering, South Kensington Campus, SW7 2AZ, London, London, United Kingdom (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Medical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
1997/09/01 - 2001/06/22
Concluded
 chimie des biomolecules (Doctorat)
Université Toulouse III Paul Sabatier, France
1996/09/01 - 1997/06/30
Concluded
 Chimie des Biomolecules (DEA)
Université Toulouse III Paul Sabatier, France
Affiliation

Science

Category
Host institution 		Employer
2006/09/01 - 2010/06/30 Principal Investigator (Research) Centre National de la Recherche Scientifique, France
Institut de Science et d'Ingénierie Supramoléculaires, France

Teaching in Higher Education

Category
Host institution 		Employer
2010/07/01 - Current Lecturer (University Teacher) Imperial College London, United Kingdom
Imperial College London, United Kingdom
Projects

Grant

Designation Funders
2018/06/15 - 2020/09/30 Engineering and validation of a modular and non-invasive screening tool for Cancer based on automated microRNA profiling from whole blood with paper-hydrogel electrochemical sensors
C49996/A26141
Principal investigator
Imperial College London, United Kingdom
 Cancer Research UK
Ongoing
2012/06/01 - 2015/05/31 G-quadruplexes in gene promoters and untranslated regions: myth or reality
RPG-2012-603
Principal investigator
Imperial College London, United Kingdom
Concluded

Other

Designation Funders
2019/07/01 - 2022/06/30 Engineering of a predictive point-of-care test for preterm birth based on automated microRNA profiling on paper
WSCR_P80733
Principal investigator
Imperial College London, United Kingdom
 March of Dimes Foundation
Ongoing
Outputs

Publications

Journal article
  1. Dana Al Sulaiman; Jason Y. H. Chang; Nitasha R. Bennett; Helena Topouzi; Claire A. Higgins; Darrell J. Irvine; Sylvain Ladame. "Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid". ACS Nano (2019): https://doi.org/10.1021/acsnano.9b04783.
    10.1021/acsnano.9b04783
  2. Philip Gillespie; Sylvain Ladame; Danny O'Hare. "Molecular methods in electrochemical microRNA detection". The Analyst (2019): https://doi.org/10.1039/C8AN01572D.
    10.1039/C8AN01572D
  3. Suraj Pavagada; Robert B. Channon; Jason Y. H. Chang; Sung Hye Kim; David MacIntyre; Phillip R. Bennett; Vasso Terzidou; Sylvain Ladame. "Oligonucleotide-templated lateral flow assays for amplification-free sensing of circulating microRNAs". Chemical Communications 55 83 (2019): 12451-12454. https://doi.org/10.1039/C9CC05607F.
    10.1039/C9CC05607F
  4. Dana Al Sulaiman; Paolo Cadinu; Aleksandar P. Ivanov; Joshua B. Edel; Sylvain Ladame. "Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing". Nano Letters (2018): https://doi.org/10.1021/acs.nanolett.8b03111.
    10.1021/acs.nanolett.8b03111
  5. Dana Al Sulaiman; Jason Y. H. Chang; Sylvain Ladame. "Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity". Angewandte Chemie International Edition 56 19 (2017): 5247-5251. https://doi.org/10.1002/anie.201701356.
    10.1002/anie.201701356
  6. Dana Al Sulaiman; Jason Y. H. Chang; Sylvain Ladame. "Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity". Angewandte Chemie 129 19 (2017): 5331-5335. https://doi.org/10.1002/ange.201701356.
    10.1002/ange.201701356
  7. Metcalf GA; Shibakawa A; Patel H; Sita-Lumsden A; Zivi A; Rama N; Bevan CL; Ladame S. "Amplification-Free Detection of Circulating microRNA Biomarkers from Body Fluids Based on Fluorogenic Oligonucleotide-Templated Reaction between Engineered Peptide Nucleic Acid Probes: Application to Prostate Cancer Diagnosis.". Analytical chemistry (2016): http://europepmc.org/abstract/med/27498854.
    10.1021/acs.analchem.6b01594
  8. Zuffo M; Doria F; Spalluto V; Ladame S; Freccero M. "Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad.". Chemistry (Weinheim an der Bergstrasse, Germany) (2015): http://europepmc.org/abstract/med/26463116.
    10.1002/chem.201503020