Adelaide Fernandes (2F17-4BE1-A074)

Curriculum Vitae

Adelaide Fernandes

Adelaide Fernandes received her degree in Pharmaceutical Sciences in 2002. She performs neuroscience research since 2002. Her PhD studies focused on glia reactivity during neonatal development were performed at the Faculty of Pharmacy of the University of Lisbon (FFULisboa), having received her PhD in 2006, from the University of Lisbon. From 2006 to 2010 she developed post-doctoral studies focused on changed on neuronal development and myelination during early postnatal conditions, at Research Institute for Medicines (iMed.Ulisboa) and Department of Neuroscience, University of Minneapolis. She is Assistant Professor at FFUlisboa since 2011. Adelaide research focuses on neuron-glial interplay during neurodevelopment and neurodegenerative disorders. Adelaide explored the impact of neurodevelopmental disorders (e.g. jaundice, sepsis) on astrogliosis, neurodegeneration and recently on oligodendrogenesis and myelination. Presently, Adelaide focus on neuroinflammation in neurodegenerative disorders, as Multiple Sclerosis and in ageing associated Alzheimer’s disease, namely in inflammatory cross-talk between neurons and glial cells with a particular interest in microglia phenotype, using organotypic cultures, 3D cellular systems derived from induced Pluripotent Stem Cells or animal models of degenerative disorders. Her work granted her a Medal of Honour L’Óreal for Women in Science – L’Óreal/UNESCO/FCT in 2011, an Innovation Research Grant from Portuguese Pharmaceutical Society in 2013, a National-FCT funded project and a Grant for Multiple Sclerosis Innovation by Merck-Serono in 2017, in parallel with funding from other research projects and procurement agreements.

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Identification

Personal identification

Full name: Adelaide Fernandes

Citation names

Fernandes, Adelaide

Author identifiers

Ciência ID: 2F17-4BE1-A074
ORCID iD: 0000-0002-2782-9519

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2006 Concluded	Pharmacy (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal "Mechanisms of astrocyte inflammatory response to UCB and modulation by immunosuppressive therapy" (THESIS/DISSERTATION)	Unanimous summa cum laude
2002 Concluded	Pharmaceutical Sciences (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal	16 (dezasseis) valores

Affiliation

Science

	Category Host institution	Employer
2015 - Current	Principal Investigator (Research)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2023/07/01 - Current	Associate Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/12/01 - 2023/06/30	Assistant Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

	Category Host institution	Employer
2009/07/01 - 2010/11/30	Research Assistant C2008-FFUL-UBMBE-02-2008, Ciência 2008.	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

2006/10/01 - 2009/06/30	Postdoctoral student (SFRH/BPD/26390/2006)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2002/10/01 - 2006/09/30	PhD Student	Universidade de Lisboa Faculdade de Farmácia, Portugal

2002/04/01 - 2002/09/30	Research Fellow	Universidade de Lisboa Faculdade de Farmácia, Portugal

1999/09/01 - 2001/09/30	Trainee student	Universidade de Lisboa Faculdade de Farmácia, Portugal

Projects

Grant

	Designation	Funders
2024/01/01 - 2025/12/01	Microbiome manipulation to reduce psychopathology in Multiple Sclerosis BiocodexMicrobiota 2024 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Biocodex Microbiota Foundation Ongoing
2022/01 - 2024/12	Análise da desregulação neuroimmune na doença de Alzheimer para uma terapia com miRNAs veiculados por exosomas Provided by PTCRIS: PTDC/MED-NEU/2382/2021 Researcher	Fundação para a Ciência e a Tecnologia
2022/01 - 2024/12	A interação entre a resposta imune inata e a adquirida como base do defice cognitivo presente na Esclerose Múltipla Provided by PTCRIS: PTDC/MED-PAT/2582/2021 Principal investigator	Fundação para a Ciência e a Tecnologia
2022/01 - 2023/12	A interação da microglia e das células T na base da excessiva eliminação de sinapses associada ao défice cognitivo na Esclerose Múltipla 688273478011411110311497109973280698383796547202109209472022DRI Principal investigator	Fundação para a Ciência e a Tecnologia
2020/01 - 2023/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UIDP/04138/2020 Researcher	Fundação para a Ciência e a Tecnologia
2020/01 - 2023/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UIDB/04138/2020 Researcher	Fundação para a Ciência e a Tecnologia
2022/01 - 2023/06	Papel da obesidade na esclerose múltipla: identificação de microRNAs relacionados com o desenvolvimento dos oligodendrócitos como novos alvos terapêuticos para promover a remielinização Provided by PTCRIS: EXPL/MED-NEU/1033/2021 Researcher	Fundação para a Ciência e a Tecnologia
2022 - 2023	Unraveling the role of glial cells in ARSACS ARSACS2022 Co-Principal Investigator (Co-PI) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Ataxia Canada Concluded
2018/10 - 2022/09	Novas Substâncias Psicoativas, Cérebro e Adolescência - Uma Plataforma de Avaliação de Risco Provided by PTCRIS: PTDC/SAU-TOX/32515/2017 Researcher	Fundação para a Ciência e a Tecnologia
2018/09 - 2022/08	Detetar, prevenir, erradicar: uma estratégia concertada para combater a metastização do cancro da mama para o encéfalo Provided by PTCRIS: PTDC/MED-ONC/29402/2017 Researcher	Fundação para a Ciência e a Tecnologia
2018/08 - 2022/08	Desenvolvimento de uma terapia para uso de exosomas autólogos após modulação de microRNAs em microglia e neurónios-motores recorrendo a modelos animais e humanos de esclerose lateral amiotrófica ELA Provided by PTCRIS: PTDC/MED-NEU/31395/2017 Researcher	Fundação para a Ciência e a Tecnologia
2018/07/01 - 2021/06/30	Targeting multiple sclerosis immune- and psycho-pathophysiology by modulation of neuroinflammation GMSI2017 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Merck KGaA Ongoing
2019/01 - 2019/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UID/DTP/04138/2019 Researcher	Fundação para a Ciência e a Tecnologia
2018/09 - 2019/09	New molecules to characterize & treat demyelinating lesions - MyelinBASHY YiMed-2018 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Concluded
2016/01 - 2019/06	Geração de modelos celulares e animais aperfeiçoados para identificação do fenótipo e de novos alvos terapêuticos na Doença de Alzheimer Provided by PTCRIS: JPCOFUND/0003/2015 Researcher	Fundação para a Ciência e a Tecnologia
2017 - 2019	Identification and assessment of new psychoactive substances: a European network - co-funded by the European Union HOME/2014/JDRU/AG/DRUG/7086 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Concluded
2015/01 - 2018/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UID/DTP/04138/2013 Researcher	Fundação para a Ciência e a Tecnologia
2015 - 2018	Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) COST Action BM1402 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Concluded
2014/03 - 2015/08	Decrifrar como os microRNAs regulam o fenótipo da microglia na Doença de Alzheimer Provided by PTCRIS: EXPL/NEU-NMC/1003/2013 Researcher	Fundação para a Ciência e a Tecnologia
2012/01 - 2015/07	SERÁ A MICROGLIA UM NOVO ALVO FARMACOLÓGICO COM POTENCIAL INTERESSE NA ESCLEROSE LATERAL AMIOTRÓFICA ELA? Provided by PTCRIS: PTDC/SAU-FAR/118787/2010 Researcher	Fundação para a Ciência e a Tecnologia
2014/03 - 2015/02	Decoding the regulation of microglia phenotype by microRNAs in Alzheimer's Disease 134028 Provided by PTCRIS: 134028 Principal investigator	Fundação para a Ciência e a Tecnologia, I.P.
2014/02 - 2014/09	LisbonLiving+: Innovative strategies for a healthy life and an active ageing in the Region of Lisbon Provided by PTCRIS: 135837 135837 Researcher	Fundação para a Ciência e a Tecnologia, I.P.
2013/10 - 2014/09	Role of S100B in multiple sclerosis: from a biomarker to a therapeutic target Ordem Farmaceuticos2013 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Ordem dos Farmaceuticos Concluded
2011/01 - 2013/12	Projecto Estratégico - UI 4013 - 2011-2012 123298UID Researcher	Fundação para a Ciência e a Tecnologia
2007/07 - 2011/04	Estudo da perturbação da barreira hemato-encefálica por neurotoxinas e modulação por agentes terapêuticos num modelo humano: efeitos da bilirrubina e da endotoxina em células endoteliais de capilares cerebrais e acção protectora de ácidos biliares Provided by PTCRIS: PTDC/SAU-FCF/68819/2006 Researcher	Fundação para a Ciência e a Tecnologia
2007/07 - 2010/12	À descoberta de potenciais alterações de neurodesenvolvimento em situações comuns no período neonatal, tais como na hiperbilirrubinemia e na inflamação Provided by PTCRIS: PTDC/SAU-NEU/64385/2006 64385 Provided by PTCRIS: 64385 Researcher	Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2009/07	Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators Provided by PTCRIS: 82303 82303 Researcher	Fundação para a Ciência e a Tecnologia, I.P.
2006/10 - 2009/06	MODULATION OF GROWTH CONE BEHAVIOR AND AXONAL CONNECTIONS FORMATION IN DEVELOPING NERVOUS SYSTEM BY TOXICANTS POTENTIALLY RELATED WITH SCHIZOPHRENIA Provided by PTCRIS: SFRH/BPD/26390/2006 Post-doc Fellow	Fundação para a Ciência e a Tecnologia
2005/09 - 2008/06	Lesão cerebral pela bilirrubina e impacto nas doenças neurodegenerativas - À procura de sensores, susceptilidades e moduladores Provided by PTCRIS: POCI/SAU-MMO/55955/2004 PhD Student Fellow	Fundação para a Ciência e a Tecnologia
2002/10 - 2006/09	RESPOSTA INFLAMATÓRIA DAS CÉLULAS NERVOSAS A AGENTES NEUROTÓXICOS COMO A BILIRRUBINA, A ENDOTOXINA E A AMÓNIA. MODULAÇÃO PELA VITAMINA-E E IL-10 Provided by PTCRIS: SFRH/BD/9204/2002 PhD Student Fellow	Fundação para a Ciência e a Tecnologia

Contract

	Designation	Funders
2023/07/01 - 2028/06/30	SIMPATHIC - Accelerating drug repurposing for rare neurological, neurometabolic and neuromuscular disorders by exploiting SIMilarities in clinical and molecular PATHology SYMPATHIC Researcher Universidade de Lisboa Faculdade de Farmácia, Portugal	European Research Executive Agency Ongoing
2015 - 2016	Evaluation of the impact of ingredients on myelination markers in an ex vivo cerebellar slice culture mode Nestle2014 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Nestlé Lausanne Concluded

Outputs

Publications

Book chapter

Fernandes, Adelaide; Barateiro, A.; Afonso, V.; Brites, D.; Santos, G.; Fernandes, A.. "Role of S100B on Oligodendrocyte Physiology and Pathology.". In Oligodendrocytes: Biology, Functions and Role in the Pathology of Diseases. Nova Science Publishers, 2015.
Published • 10.1002/9781634638722.ch5
Fernandes, Adelaide; Vaz, A.R.; Brites, D.. "S100b as a candidate biomarker and therapeutic target in neurodegenerative disorders.". In S100B: Serum Detection, Functions and Clinical Significance. Nova Science Publishers, 2015.
Published

Journal article

Barateiro, A.; Barros, C.; Pinto, M.V.; Ribeiro, A.R.; Alberro, A.; Fernandes, A.. "Women in the field of multiple sclerosis: How they contributed to paradigm shifts". Frontiers in Molecular Neuroscience 16 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85148413021&partnerID=MN8TOARS.
10.3389/fnmol.2023.1087745
Neto, A.; Fernandes, A.; Barateiro, A.. "The complex relationship between obesity and neurodegenerative diseases: an updated review". Frontiers in Cellular Neuroscience 17 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85177635639&partnerID=MN8TOARS.
10.3389/fncel.2023.1294420
Gonçalo Garcia; Sara Pinto; Sofia Ferreira; Daniela Lopes; Maria João Serrador; Adelaide Fernandes; Ana Rita Vaz; et al. "Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease". Cells (2022): https://doi.org/10.3390/cells11213377.
10.3390/cells11213377
Catarina Barros; Andreia Barateiro; Alexandre Neto; Beatriz Soromenho; Afonso P. Basto; Joana M. Mateus; Sara Xapelli; et al. "S100B inhibition protects from chronic experimental autoimmune encephalomyelitis". Brain Communications (2022): https://doi.org/10.1093/braincomms/fcac076.
10.1093/braincomms/fcac076
Ana Rita Ribeiro; Catarina Barros; Andreia Barateiro; Susan E Howlett; Adelaide Fernandes; David Le Couteur. "Improved Assessment of Overall Health in Variably Aged Murine Models of Multiple Sclerosis With a Novel Frailty Index Tool". The Journals of Gerontology: Series A (2022): https://doi.org/10.1093/gerona/glab185.
10.1093/gerona/glab185
Adelaide Fernandes; Cláudia Caldeira; Carolina Cunha; Elisabete Ferreiro; Ana Rita Vaz; Dora Brites. "Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice". Cells (2022): https://doi.org/10.3390/cells11010137.
10.3390/cells11010137
Garcia, G.; Fernandes, A.; Stein, F.; Brites, D.. "Protective Signature of IFN¿-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130760459&partnerID=MN8TOARS.
10.3389/fphar.2022.833066
Acúrcio, R.C.; Pozzi, S.; Carreira, B.; Pojo, M.; Gómez-Cebrián, N.; Casimiro, S.; Fernandes, A.; et al. "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment". Journal for ImmunoTherapy of Cancer 10 7 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85134789748&partnerID=MN8TOARS.
10.1136/jitc-2022-004695
Maria V. Pinto; Fábio M. F. Santos; Catarina Barros; Ana Rita Ribeiro; Uwe Pischel; Pedro M. P. Gois; Adelaide Fernandes. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163-3163. https://doi.org/10.3390/cells10113163.
10.3390/cells10113163
Gonçalo Garcia; Sara Pinto; Mar Cunha; Adelaide Fernandes; Jari Koistinaho; Dora Brites. "Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor". Cells 10 9 (2021): 2424-2424. https://doi.org/10.3390/cells10092424.
10.3390/cells10092424
Ainhoa Alberro; Leire Iparraguirre; Adelaide Fernandes; David Otaegui. "Extracellular Vesicles in Blood: Sources, Effects, and Applications". International Journal of Molecular Sciences 22 15 (2021): 8163-8163. https://doi.org/10.3390/ijms22158163.
10.3390/ijms22158163
Maria J. S. A. Silva; Hélio Faustino; Jaime A. S. Coelho; Maria V. Pinto; Adelaide Fernandes; Ismael Compañón; Francisco Corzana; et al. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie 60 19 (2021): 10850-10857. https://doi.org/10.1002/ange.202016936.
10.1002/ange.202016936
Barros, C.; Fernandes, A.. "Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools". Multiple Sclerosis and Related Disorders 47 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85096671779&partnerID=MN8TOARS.
10.1016/j.msard.2020.102622
Momtazmanesh, S.; Shobeiri, P.; Saghazadeh, A.; Teunissen, C.E.; Burman, J.; Szalardy, L.; Klivenyi, P.; et al. "Neuronal and glial CSF biomarkers in multiple sclerosis: A systematic review and meta-analysis". Reviews in the Neurosciences (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85101030060&partnerID=MN8TOARS.
10.1515/revneuro-2020-0145
Maria V. Pinto; Adelaide Fernandes. "Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21175960.
10.3390/ijms21175960
Ribeiro, A.R.; Howlett, S.E.; Fernandes, A.. "Frailty—A promising concept to evaluate disease vulnerability". Mechanisms of Ageing and Development 187 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85080084499&partnerID=MN8TOARS.
10.1016/j.mad.2020.111217
das Neves, S.P.; Santos, G.; Barros, C.; Pereira, D.R.; Ferreira, R.; Mota, C.; Monteiro, S.; et al. "Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms". Journal of Neuroimmunology 340 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078129302&partnerID=MN8TOARS.
10.1016/j.jneuroim.2020.577163
Santos, F.M.F.; Domínguez, Z.; Fernandes, J.P.L.; Parente Carvalho, C.; Collado, D.; Pérez-Inestrosa, E.; Pinto, M.V.; et al. "Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications". Chemistry - A European Journal 26 62 (2020): 14064-14069. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091763359&partnerID=MN8TOARS.
10.1002/chem.202001623
Santos, G.; Barateiro, A.; Brites, D.; Fernandes, A.. "S100B Impairs Oligodendrogenesis and Myelin Repair Following Demyelination Through RAGE Engagement". Frontiers in Cellular Neuroscience 14 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85091209245&partnerID=MN8TOARS.
10.3389/fncel.2020.00279
de Mello-Sampayo, C.; Vaz, A.R.; Henriques, S.C.; Fernandes, A.; Paradinha, F.; Florindo, P.; Faria, P.; et al. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment". Neurotoxicity Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086428280&partnerID=MN8TOARS.
10.1007/s12640-020-00229-6
Rocha, J.; Leandro, R.; Direito, R.; Gonçalves, M.; Duarte, M.P.; Fernandes, A.; Sepodes, B.; Figueira, M.-E.. "Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice". Applied Sciences (Switzerland) 10 23 (2020): 1-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096646571&partnerID=MN8TOARS.
10.3390/app10238465
Rosa Direito; João Rocha; Ana-Teresa Serra; Adelaide Fernandes; Marisa Freitas; Eduarda Fernandes; Rui Pinto; et al. "Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis". Journal of Dietary Supplements (2019): https://doi.org/10.1080/19390211.2019.1645256.
10.1080/19390211.2019.1645256
João Rocha; Ana Lima; Maria Margarida Gonçalves; Maria Paula Duarte; Vanessa Mateus; Catarina Sousa; Fernandes A; et al. "Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice". Medicines (2019): https://www.mdpi.com/2305-6320/6/2/65.
10.3390/medicines6020065
Markus Schosserer; Gareth Banks; Soner Dogan; Peter Dungel; Adelaide Fernandes; Darja Marolt Presen; Ander Matheu; et al. "Modelling physical resilience in ageing mice". Mechanisms of Ageing and Development 177 (2019): 91-102. https://doi.org/10.1016/j.mad.2018.10.001.
10.1016/j.mad.2018.10.001
Mendes, C.; Rocha, J.; Direito, R.; Fernandes, A.; Sepodes, B.; Figueira, M.-E.; Ribeiro, M.H.. "Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices". Journal of Functional Foods 63 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072299230&partnerID=MN8TOARS.
10.1016/j.jff.2019.103564
Rocha, J.; Direito, R.; Lima, A.; Mota, J.; Gonçalves, M.; Duarte, M.P.; Solas, J.; et al. "Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice". Biomedicine and Pharmacotherapy 118 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070874907&partnerID=MN8TOARS.
10.1016/j.biopha.2019.109351
Ana Luisa Cardoso; Adelaide Fernandes; Juan Antonio Aguilar-Pimentel; Martin Hrabe de Angelis; Joana Ribeiro Guedes; Maria Alexandra Brito; Saida Ortolano; et al. "Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases". Ageing Research Reviews 47 (2018): 214-277. https://doi.org/10.1016/j.arr.2018.07.004.
10.1016/j.arr.2018.07.004
Cunha, C.; Santos, C.; Gomes, C.; Fernandes, A.; Correia, A.M.; Sebastião, A.M.; Vaz, A.R.; Brites, D.. "Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage". Molecular Neurobiology 55 5 (2018): 4207-4224. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020723635&partnerID=MN8TOARS.
10.1007/s12035-017-0631-2
Santos, G.; Barateiro, A.; Gomes, C.M.; Brites, D.; Fernandes, A.. "Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment". Neuropharmacology 129 (2018): 69-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034070602&partnerID=MN8TOARS.
10.1016/j.neuropharm.2017.11.002
Fernandes, A.; Ribeiro, A.R.; Monteiro, M.; Garcia, G.; Vaz, A.R.; Brites, D.. "Secretome from SH-SY5Y APPSwecells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling". Biochimie (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85048597442&partnerID=MN8TOARS.
10.1016/j.biochi.2018.05.015
Direito, R.; Lima, A.; Rocha, J.; Ferreira, R.B.; Mota, J.; Rebelo, P.; Fernandes, A.; et al. "Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities". Journal of Nutritional Biochemistry 46 (2017): 100-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018410246&partnerID=MN8TOARS.
10.1016/j.jnutbio.2017.03.002
Caldeira, C.; Cunha, C.; Vaz, A.R.; Falcão, A.S.; Barateiro, A.; Seixas, E.; Fernandes, A.; Brites, D.. "Key aging-associated alterations in primary microglia response to beta-amyloid stimulation". Frontiers in Aging Neuroscience 9 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030703999&partnerID=MN8TOARS.
Barateiro, A.; Afonso, V.; Santos, G.; Cerqueira, J.J.; Brites, D.; van Horssen, J.; Fernandes, A.. "S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis". Molecular Neurobiology 53 6 (2016): 3976-3991. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937132572&partnerID=MN8TOARS.
10.1007/s12035-015-9336-6
Figueira, I.; Fernandes, A.; Mladenovic Djordjevic, A.; Lopez-Contreras, A.; Henriques, C.M.; Selman, C.; Ferreiro, E.; et al. "Interventions for age-related diseases: Shifting the paradigm". Mechanisms of Ageing and Development 160 (2016): 69-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999035290&partnerID=MN8TOARS.
10.1016/j.mad.2016.09.009
Figueira, M.-E.; Oliveira, M.; Direito, R.; Rocha, J.; Alves, P.; Serra, A.-T.; Duarte, C.; et al. "Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat". Biomedicine and Pharmacotherapy 83 (2016): 1191-1202. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989266756&partnerID=MN8TOARS.
10.1016/j.biopha.2016.08.040
Barateiro, A.; Brites, D.; Fernandes, A.. "Oligodendrocyte development and myelination in neurodevelopment: Molecular mechanisms in health and disease". Current Pharmaceutical Design 22 6 (2016): 656-679. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958232730&partnerID=MN8TOARS.
10.2174/1381612822666151204000636
Barateiro, A.; Chen, S.; Yueh, M.-F.; Fernandes, A.; Domingues, H.S.; Relvas, J.; Barbier, O.; et al. "Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia". Molecular Pharmacology 89 1 (2016): 84-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958151344&partnerID=MN8TOARS.
10.1124/mol.115.098228
Silva, S.; Sepodes, B.; Rocha, J.; Direito, R.; Fernandes, A.; Brites, D.; Freitas, M.; et al. "Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis". Journal of Nutritional Biochemistry 26 4 (2015): 360-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925341472&partnerID=MN8TOARS.
10.1016/j.jnutbio.2014.11.011
Rocha, J.; Figueira, M.-E.; Barateiro, A.; Fernandes, A.; Brites, D.; Pinto, R.; Freitas, M.; et al. "Inhibition of glycogen synthase kinase-3ß attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat". Shock 43 4 (2015): 369-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924905290&partnerID=MN8TOARS.
10.1097/SHK.0000000000000298
Vila-Real, H.; Coelho, H.; Rocha, J.; Fernandes, A.; Ventura, M.R.; Maycock, C.D.; Iranzo, O.; Simplício, A.L.. "Peptidomimetic ß-Secretase Inhibitors Comprising a Sequence of Amyloid-ß Peptide for Alzheimer's Disease". Journal of Medicinal Chemistry 58 14 (2015): 5408-5418. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937675445&partnerID=MN8TOARS.
10.1021/acs.jmedchem.5b00658
Brites, D.; Fernandes, A.. "Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities". Seminars in Fetal and Neonatal Medicine 20 1 (2015): 14-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922931419&partnerID=MN8TOARS.
10.1016/j.siny.2014.12.002
Cardoso, F.L.; Herz, J.; Fernandes, A.; Rocha, J.; Sepodes, B.; Brito, M.A.; McGavern, D.B.; Brites, D.. "Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects". Journal of Neuroinflammation 12 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929431467&partnerID=MN8TOARS.
10.1186/s12974-015-0299-3
Rocha, J.; Eduardo-Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Bronze, R.; Duarte, C.M.; et al. "Anti-inflammatory effect of rosmarinic acid and an extract of rosmarinus officinalis in rat models of local and systemic inflammation". Basic and Clinical Pharmacology and Toxicology 116 5 (2015): 398-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926358222&partnerID=MN8TOARS.
10.1111/bcpt.12335
Brites, D.; Fernandes, A.. "Neuroinflammation and depression: Microglia activation, extracellular microvesicles and microRNA dysregulation". Frontiers in Cellular Neuroscience 9 DEC (2015): 1-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954068135&partnerID=MN8TOARS.
10.3389/fncel.2015.00476
Marto, J.; Baltazar, D.; Duarte, A.; Fernandes, A.; Gouveia, L.; Militão, M.; Salgado, A.; et al. "Topical gels of etofenamate: in vitro and in vivo evaluation". Pharmaceutical Development and Technology 20 6 (2015): 710-715. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964238161&partnerID=MN8TOARS.
10.3109/10837450.2014.915571
Figueira, M.E.; Câmara, M.B.; Direito, R.; Rocha, J.; Serra, A.T.; Duarte, C.M.M.; Fernandes, A.; et al. "Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis". Food and Function 5 12 (2014): 3241-3251. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912123071&partnerID=MN8TOARS.
10.1039/c4fo00376d
Ratilal, B.O.; Rocha, J.P.F.; Fernandes, A.M.A.; Arroja, M.M.C.; Barateiro, A.P.; Brites, D.M.T.O.; Pinto, R.M.A.; Sepodes, B.M.N.; Mota-Filipe, H.D.. "TDZD-8 pre-treatment in transient middle cerebral artery occlusion". Biomedicine and Aging Pathology 4 4 (2014): 361-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908333539&partnerID=MN8TOARS.
10.1016/j.biomag.2014.07.005
Barateiro, A.; Domingues, H.S.; Fernandes, A.; Relvas, J.B.; Brites, D.. "Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-a inhibitors". Molecular Neurobiology 49 1 (2014): 424-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894373448&partnerID=MN8TOARS.
10.1007/s12035-013-8530-7
Barateiro, A.; Fernandes, A.. "Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination". Biochimica et Biophysica Acta - Molecular Cell Research 1843 9 (2014): 1917-1929. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902532010&partnerID=MN8TOARS.
10.1016/j.bbamcr.2014.04.018
Fernandes, A.; Miller-Fleming, L.; Pais, T.F.. "Microglia and inflammation: conspiracy, controversy or control?". Cellular and molecular life sciences : CMLS 71 20 (2014): 3969-3985. http://www.scopus.com/inward/record.url?eid=2-s2.0-84909987977&partnerID=MN8TOARS.
10.1007/s00018-014-1670-8
Torrado, E.F.; Gomes, C.; Santos, G.; Fernandes, A.; Brites, D.; Falcão, A.S.. "Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population". International Journal of Developmental Neuroscience 37 (2014): 94-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905379941&partnerID=MN8TOARS.
10.1016/j.ijdevneu.2014.07.001
Ratilal, B.O.; Arroja, M.M.C.; Rocha, J.P.F.; Fernandes, A.M.A.; Barateiro, A.P.; Brites, D.M.T.O.; Pinto, R.M.A.; Sepodes, B.M.N.; Mota-Filipe, H.D.. "Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion: Laboratory investigation". Journal of Neurosurgery 121 1 (2014): 55-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903879102&partnerID=MN8TOARS.
10.3171/2014.2.JNS132197
Caldeira, C.; Oliveira, A.F.; Cunha, C.; Vaz, A.R.; Falcão, A.S.; Fernandes, A.; Brites, D.. "Microglia change from a reactive to an age-like phenotype with the time in culture". Frontiers in Cellular Neuroscience 8 JUN (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901848126&partnerID=MN8TOARS.
10.3389/fncel.2014.00152
Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Gomes, C.; Fernandes, A.; Barateiro, A.; Tiribelli, C.; Brites, D.; Silva, S.L.. "Cross-talk between neurons and astrocytes in response to bilirubin: Adverse secondary impacts". Neurotoxicity Research 26 1 (2014): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903741375&partnerID=MN8TOARS.
10.1007/s12640-013-9427-y
Rocha, J.; Eduardo-Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Pinto, R.; Freitas, M.; et al. "Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat". Inflammation 38 1 (2014): 312-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964211290&partnerID=MN8TOARS.
10.1007/s10753-014-0035-7
Mariano, C.; Palmela, I.; Pereira, P.; Fernandes, A.; Falcão, A.S.; Cardoso, F.L.; Vaz, A.R.; et al. "Tricellulin expression in brain endothelial and neural cells". Cell and Tissue Research 351 3 (2013): 397-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881223461&partnerID=MN8TOARS.
10.1007/s00441-012-1529-y
Barateiro, A.; Miron, V.E.; Santos, S.D.; Relvas, J.B.; Fernandes, A.; Ffrench-Constant, C.; Brites, D.. "Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination.". Molecular neurobiology 47 2 (2013): 632-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894303554&partnerID=MN8TOARS.
Silva, S.L.; Vaz, A.R.; Diógenes, M.J.; Van Rooijen, N.; Sebastião, A.M.; Fernandes, A.; Silva, R.F.M.; Brites, D.. "Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10". Neuropharmacology 62 7 (2012): 2397-2407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859103402&partnerID=MN8TOARS.
10.1016/j.neuropharm.2012.02.002
Barateiro, A.; Vaz, A.R.; Silva, S.L.; Fernandes, A.; Brites, D.. "ER stress, mitochondrial dysfunction and calpain/jnk activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin". NeuroMolecular Medicine 14 4 (2012): 285-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870563054&partnerID=MN8TOARS.
10.1007/s12017-012-8187-9
Barateiro, A.; Miron, V.E.; Santos, S.D.; Relvas, J.B.; Fernandes, A.; ffrench-Constant, C.; Brites, D.. "Unconjugated Bilirubin Restricts Oligodendrocyte Differentiation and Axonal Myelination". Molecular Neurobiology (2012): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867505724&partnerID=MN8TOARS.
10.1007/s12035-012-8364-8
Vaz, A.R.; Silva, S.L.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Selective vulnerability of rat brain regions to unconjugated bilirubin". Molecular and Cellular Neuroscience 48 1 (2011): 82-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960929537&partnerID=MN8TOARS.
10.1016/j.mcn.2011.06.008
Vaz, A.R.; Silva, S.L.; Barateiro, A.; Fernandes, A.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin". Experimental Neurology 229 2 (2011): 381-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956137679&partnerID=MN8TOARS.
10.1016/j.expneurol.2011.03.004
Fernandes, A.; Barateiro, A.; Falcão, A.S.; Silva, S.L.-A.; Vaz, A.R.; Brito, M.A.; Marques Silva, R.F.; Brites, D.. "Astrocyte reactivity to unconjugated bilirubin requires TNF-a and IL-1ß receptor signaling pathways". GLIA 59 1 (2011): 14-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349235777&partnerID=MN8TOARS.
10.1002/glia.21072
Mariano, C.; Silva, S.L.; Pereira, P.; Fernandes, A.; Brites, D.; Brito, M.A.. "Evidence of tricellulin expression by immune cells, particularly microglia". Biochemical and Biophysical Research Communications 409 4 (2011): 799-802. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959261876&partnerID=MN8TOARS.
10.1016/j.bbrc.2011.05.093
Palmela, I.; Cardoso, F.L.; Bernas, M.; Correia, L.; Vaz, A.R.; Silva, R.F.M.; Fernandes, A.; et al. "Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity". Current Neurovascular Research 8 2 (2011): 153-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955733304&partnerID=MN8TOARS.
10.2174/156720211795495358
Silva, S.L.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation". Neurobiology of Disease 40 3 (2010): 663-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957807564&partnerID=MN8TOARS.
10.1016/j.nbd.2010.08.010
Brito, M.A.; Vaz, A.R.; Silva, S.L.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Brites, D.. "N-methyl-D-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity". Molecular Medicine 16 9-10 (2010): 372-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956632156&partnerID=MN8TOARS.
10.2119/molmed.2009.00152
Brites, D.; Fernandes, A.; Falcão, A.S.; Gordo, A.C.; Silva, R.F.M.; Brito, M.A.. "Biological risks for neurological abnormalities associated with hyperbilirubinemia". Journal of Perinatology 29 (2009): S8-S13. http://www.scopus.com/inward/record.url?eid=2-s2.0-59549101479&partnerID=MN8TOARS.
10.1038/jp.2008.214
Fernandes, A.; Falcão, A.S.; Abranches, E.; Bekman, E.; Henrique, D.; Lanier, L.M.; Brites, D.. "Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis". Developmental Neurobiology 69 9 (2009): 568-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749127695&partnerID=MN8TOARS.
10.1002/dneu.20727
Fernandes, A.; Brites, D.. "Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents". Current Pharmaceutical Design 15 25 (2009): 2915-2926. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449389923&partnerID=MN8TOARS.
10.2174/138161209789058165
Popko, J.; Fernandes, A.; Brites, D.; Lanier, L.M.. "Automated analysis of neuronj tracing data". Cytometry Part A 75 4 (2009): 371-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549113129&partnerID=MN8TOARS.
10.1002/cyto.a.20660
Brito, M.A.; Lima, S.; Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid". NeuroToxicology 29 2 (2008): 259-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749156518&partnerID=MN8TOARS.
10.1016/j.neuro.2007.11.002
Brito, M.A.; Rosa, A.I.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells". Neurobiology of Disease 29 1 (2008): 30-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549090063&partnerID=MN8TOARS.
10.1016/j.nbd.2007.07.023
Falcão, A.S.; Bellarosa, C.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Tiribelli, C.; Brites, D.. "Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin". Neuroscience 144 3 (2007): 878-888. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845899686&partnerID=MN8TOARS.
10.1016/j.neuroscience.2006.10.026
Fernandes, A.; Vaz, A.R.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin". Journal of Neuropathology and Experimental Neurology 66 9 (2007): 789-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548454884&partnerID=MN8TOARS.
10.1097/nen.0b013e3181461c74
Falcão, A.S.; Silva, R.F.M.; Pancadas, S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus". Journal of Neuroscience Research 85 6 (2007): 1229-1239. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248141645&partnerID=MN8TOARS.
10.1002/jnr.21227
Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes". European Journal of Neuroscience 25 4 (2007): 1058-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847203682&partnerID=MN8TOARS.
10.1111/j.1460-9568.2007.05340.x
Falcão, A.S.; Silva, R.F.M.; Fernandes, A.; Brito, M.A.; Brites, D.. "Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes". Brain Research 1149 1 (2007): 191-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247503256&partnerID=MN8TOARS.
10.1016/j.brainres.2007.02.039
Silva, R.F.M.; Falcão, A.S.; Fernandes, A.; Gordo, A.C.; Brito, M.A.; Brites, D.. "Dissociated primary nerve cell cultures as models for assessment of neurotoxicity". Toxicology Letters 163 1 (2006): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644832098&partnerID=MN8TOARS.
10.1016/j.toxlet.2005.09.033
Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state". Acta Neuropathologica 112 1 (2006): 95-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745401404&partnerID=MN8TOARS.
10.1007/s00401-006-0078-4
Gordo, A.C.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Unconjugated bilirubin activates and damages microglia". Journal of Neuroscience Research 84 1 (2006): 194-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745770001&partnerID=MN8TOARS.
10.1002/jnr.20857
Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Gordo, A.C.; Gama, M.J.; Brito, M.A.; Brites, D.. "Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin". Journal of Neurochemistry 96 6 (2006): 1667-1679. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644812051&partnerID=MN8TOARS.
10.1111/j.1471-4159.2006.03680.x
Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells". Neurobiology of Disease 20 2 (2005): 199-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-26944464585&partnerID=MN8TOARS.
10.1016/j.nbd.2005.03.001
Fernandes, A.; Silva, R.F.M.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS". Journal of Neuroimmunology 153 1-2 (2004): 64-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242679583&partnerID=MN8TOARS.
10.1016/j.jneuroim.2004.04.007

Other

Other output

Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress. 2023. Rodrigues, R.S.; Moreira, J.B.; Vaz, S.H.; Barateiro, A.; Paulo, S.L.; Mateus, J.M.; Lourenço, D.M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85160346262&partnerID=MN8TOARS.
10.1101/2023.04.24.538087

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/12/01	Participar de Corpo Inteiro	18º Congresso Nacional de Esclerose Multipla SPEM (Evora, Portugal)
2023/06/26	Exploring the impact and CD8 T cells interplay in Multiple Sclerosis	14th iMed.ULisboa Postgraduate Students Meeting iMed (Lisboa, Portugal)
2023/05/01	Microglia and T cells: the dark side of cognitive impairment in multiple sclerosis	European Neuroscience Conference by Doctoral Students (ENCODS 2023) ENCODS (Faro, Portugal)
2022/12/03	O que significa Atrasar a EM?	17ª edição do Congresso Nacional da Esclerose Múltipla (CNEM) SPEM (Lisboa, Portugal)
2022/10/18	Alterations in CNS Pathogenesis of the In Vivo Model of Multiple Sclerosis: Age Impact.	VI Symposium of the Portuguese Glial Network (Porto, Portugal)
2022/07/05	The impact of age in the in vivo model of Multiple Sclerosis: insights in overall health, spinal cord pathology and gut microbiome.	13th iMed.ULisboa Posgraduate Students Meeting (Lisboa, Portugal)
2022/02/11	The impact of age in the glial-immune interplay using the in vivo model of Multiple Sclerosis	52nd Meeting of the Portuguese Society of Pharmacology/40th Clinical Pharmacological Meeting/21st Toxicology Meeting Portuguese Society of Pharmacology (Porto, Portugal)
2021/02/19	THE CELLULAR PLAYERS INTERVENING IN CEREBRAL ISCHEMIA-REPERFUSION INJURY ASSOCIATED WITH STROKE	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/19	A NEW PHARMACOLOGICAL APPROACH TO PREVENT SYNAPTIC LOSS AND PROMOTE MYELIN PHAGOCYTOSIS: A STEP FORWARD TO MODULATE COGNITIVE IMPAIRMENT AND REMYELINATION IN MS	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/19	PENTAMIDINE PREVENTS MULTIPLE SCLEROSISLIKE PATHOGENESIS BY NEUTRALIZING S100B TOXIC EFFECTS	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/19	IMPROVED FRAILTY INDEX SCALE IN IN VIVO MODEL OF MULTIPLE SCLEROSIS: A NOVEL APPROACH TO BETTER UNDERSTAND PHENOTYPIC ALTERATIONS IN DISTINCT MICE- AGED	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/18	DOES A SINGLE BINGE DOSING OF 4-CLOROETHCATHINONE (4-CEC) IMPAIR LEARNING AND MEMORY ABILITIES IN YOUNG MICE?	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/18	NANOBODY-BASED STRATEGIES TO TARGET S100B AND IMPROVE RECOVERY IN AN EX VIVO DEMYELINATING MODEL	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2020/09	Pentamidine as a new therapeutic strategy against Multiple Sclerosis-like pathology	8th Joint ACTRIMS-ECTRIMS Meeting ECTRIMS-ACTRIMS (Washington, United States)
2020/01/24	Neuronal miR-124 modulation as a dual-front approach in AD: Benefits for neuronal homeostasis and paracrine microglia immunomodulation.	Meeting Juntos pelo Fernando, Faculty of Medicine University of Lisbon (Lisboa, Portugal)
2019/11	Microglia: responders or inducers of neurodegenerative disorders	CNC Seminars Universidade de Coimbra (Coimbra, Portugal)
2019/10	Human iPSC-derived astrocytes as a model to study neuroinflammation and implications on cell to cell trafficking	1th International Meeting of Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019/10	Neuroinflammation and neurodegeneration – a gliocentric perpective	33rd Meeting for the Study Group of Cerebral Aging and Dementia Study Group of Cerebral Aging and Dementia (Curia, Portugal)
2019/09	S100B as a biomarker and therapeutic target in Multiple Sclerosis	ESN Biennial Meeting - 7th Conference on Molecular Mechanisms of Regulation in the Nervous System ESN Biennial Meeting (Milan, Italy)
2019/09	Interplay between glial-immune cells in multiple sclerosis	18th National Meeting of the Spanish Neuroscience Society (SENC), 18th National Meeting of the Spanish Neuroscience Society (SENC), (Santiago de Compostela, Spain)
2019/05/30	S100B has crucial role in neuroinflammation and immune response in the in vivo model of Multiple Sclerosis.	XIV Meeting of the Portuguese Society for Neuroscience (SPN) Portuguese Society for Neuroscience (SPN) (Lisboa, Portugal)
2019/05/29	Immunomodulation of microglia inflammatory repertoire by dynamic miR-124 signature of APP-Swe neuronal cells.	IV Symposium of the Portuguese Glial Network Portuguese Glial Network (Lisboa, Portugal)
2019/05	Microglia: much more than M1 and M2 phenotypes	IV Symposium of the Portuguese Glial Network Portuguese Glial Network (Lisboa, Portugal)
2019/03/26	Morphological and inflammatory aberrancies in homogeneous and heterogeneous populations of human astrocytes generated from AD-iPSCs and consequences in exosomal cargo	14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD 2019) (Lisboa, Portugal)
2019/03/26	Overexpression of mir-124 in APP-Swe cells is a protective mechanism to maintain their morphology and reduce exosomal inflammatory-miRNA cargo.	14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD) (Lisboa, Portugal)
2019/02/14	Targeting S100B prevents in vivo Multiple Sclerosis-like pathology.	5th International Porto Congress of Multiple Sclerosis (Porto, Portugal)
2019/01	Relevance of neuroinflammation in demyelinating disorders: from pathogenesis to therapeutic targeting.	Chemistry Biology Crosstalks Department of Chemistry, Faculdade de Farmácia, Universidade de Lisboa (Lisboa, Portugal)
2018/06	Neuroinflammation in Mutiple Sclerosis: from target discovery to development of a therapeutic strategy	Seminários CNC (coimbra, Portugal)
2018/03	Multiple sclerosis: a journey from target discovery to therapeutic strategy assay.	9th AIMS - Annual International Medical Students Meeting. (Lisbo, Portugal)
2018/02	Exosomes from SH-APPSwe cells recapitulate their microRNA profile and trigger microglial autophagic dysfunction	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia Faculty of Medicine of the University of Lisbon (Lisboa, Portugal)
2017/11	Role of astrocyte activation in demyelination. ongress of Portuguese society of Neurology. Lisboa, Portugal, Nov 16-18, 2017.C	Congress of Portuguese society of Neurology. (lis, Portugal)
2017/05	Glia interplay during demyelination.	II Symposium – Portuguese Glial Network. Glial cells: much more than glue. ICVS/3B’s, (Braga , Portugal)
2016/11	Targeting in situ neuroinflammation in MS.	6th Annual Meeting Frontiers in Neurology (FIN6). Trinity College Dublin, (Dublin, Ireland)
2016/11	Tackling neuroinflammation in multiple sclerosis.	I Symposium – Portuguese Glial Network. ICVS/3B’s, (Braga, Portugal)
2016/06	Neuron-glial interplay during neurodevelopment and neurodegenerative disorders.	Understanding the Molecular Brain in Health and Disease Simposium. Faculdade Ciências Universidade Lisboa, (lisbo, Portugal)
2015/11	Tackling S100B as a new player in Multiple Sclerosis.	I Congress in Health Sciences Research towards Innovation and entrepreneurship. (covilhã, Portugal)
2015/06	Tackling S100B in Multiple Sclerosis.	Neuroscience Seminars. IMM, FMULisboa (Lisboa, Portugal)
2015/03	S100B: a new crucial player in Multiple Sclerosis.	VI Jornadas Nacionais de Ciências Biomédicas, Universidade Algarve, (Faro, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - Current	Avanços na investigação sobre linfomas: do diagnóstico à terapia Supervisor	Análises Clínicas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Current	Envolvimento do sistema nervoso central (SNC) em neoplasias malignas hematológicas Supervisor	Análises Clínicas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Current	Linfoma Nodal da Zona Marginal – O peso dos critérios morfológicos, fenotípicos e clínicos no diagnóstico da doença, análise retrospetiva Co-supervisor	Análises Clínicas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - Current	Investigating Microglia-T Cell Interactions and Demyelination in a 3D Brainsphere Model of Multiple Sclerosis: Development of new therapeutic Strategies Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - Current	Cerebral spinal fluid and plasma biomarkers in late-onset Spinal Muscular Atrophy patients treated with Nusinersen Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - Current	Hericium erinaceus polyphenolic and polysaccharides on the strive against Alzheimer’s Disease Supervisor	Qualidade Alimentar e Saúde (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - Current	Deciphering the role of microglia-T cells interplay upon viral infection: impact in Multiple Sclerosis progression Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - Current	Nanovaccine for oral immunisation to break the link between periodontitis and Alzheimer’s disease Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - Current	BDNF receptor cleavage in Alzheimer's disease: unveiling the impact on microglia Co-supervisor	Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2022 - Current	Avaliação do risco cardiovascular em doentes com hiperferritinemia Supervisor	Análises Clínicas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/10/01 - 2023/11	New in vitro model of microglia-derived from human PBMCs to unravel their contribution in neurodegenerative disorders Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - 2023/05/31	Innovative platform for in vivo imaging of myelin clearance during Multiple Sclerosis progression Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023	Mieloma Múltiplo: do Diagnóstico à Terapêutica Supervisor	Análises Clínicas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023	O papel da microglia no desenvolvimento da Esclerose Múltipla Supervisor	Análises Clínicas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2023	Terapêutica com células CAR-T: Novas Aplicações Terapêuticas em Doenças Hematológicas Supervisor	Análises Clínicas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2023	Deciphering the role of neuroinflammation in the psycho-pathology and frailty index of multiple sclerosis Supervisor of Ana Rita Ribeiro	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/01 - 2022/12	Detection of Age-associated Changes of the Targets of Disease Modifying Therapies in Multiple Sclerosis Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/01 - 2022/12	Neuronal and behavioral alterations after intake of N-ethylpentylone in CD-1 mice Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/01 - 2021/11/09	Effects of Newly Detected Synthetic Cathinones on the Central Nervous System Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09 - 2021/03	The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammation. Supervisor of Mafalda Manso	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09 - 2021/01/29	Organotypic brain slice cultures as a model to study supressors of amyloid-ß toxicity relevant in Alzheimer’s disease. Co-supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09 - 2021/01	Role of CNS cells in ischemia-reperfusion lesion associated with stroke. Co-supervisor of Sofia Santos	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09 - 2020/12/17	Tackling the role of S100B and associated neuroinflammation in an ex vivo demyelinating model. Supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2020/06/05	Role of S100B in EAE pathogenesis Supervisor	Neurociências (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019/10	BASHY dyes for characterization of demyelination and possible microglia targeting Supervisor	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2019	Benefits of targeting microRNAs to prevent AD-related neurodegeneration and inflammation by cell-derived exosomes Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2019	The role of S100B in Multiple Sclerosis: from a biomarker to a therapeutic target Supervisor of Andreia Barateiro
2013/09/01 - 2018/04/04	DECIPHERING THE INVOLVEMENT OF S100B-RAGE AXIS IN INFLAMMATION-ASSOCIATED MYELIN DAMAGE Supervisor of Gisela Santos	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Target S100B to reduce Experimental Autoimmune Encephalomyelitis pathogenesis Supervisor of Catarina da Silva Barros	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Vesicular Trafficking in Alzheimer’s Disease Co-supervisor of Sofia Gravanita Ferreira	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2017	S100B targeting to reduce demyelination and EAE pathogenesis Supervisor of Pedro Filipe Marques Pascoal	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Dissecting deregulated cell-to-cell communication in in vitro Alzheimer’s Disease models Co-supervisor	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2017	Evaluation of neuroprotective and neurotoxic functions of different microglia phenotypes in Alzheimer’s disease onset and progression, using in-vitro and in-vivo models Co-supervisor of Claudia Caldeira	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2016	Role of microRNA in microglial phenotype during the progression of Alzheimer’s disease Supervisor of Mafalda Aurélio Monteiro	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015	Modulation of microglia reactivity by S100B in Multiple Sclerosis Supervisor of Carla Isabel Silveira Ferreira	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2014	Role of S100B on central nervous system demyelination and remyelination Supervisor of Vera Alexandra Padrela Martins Afonso	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012	Bilirubin dysregulates myelination in early neonatal life Co-supervisor of Andreia Barateiro	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019 - Current	XIV European Meeting on Glial Cells in Health and Disease - Local organizing committee (2019) Congress (Member of the Organising Committee)
2019 - Current	IV Symposium of the Portuguese Glial Network - organizing committee (2019) Symposium (Member of the Organising Committee)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - Current	Cientificamente Provável, the participation of iMed.ULisboa in this initiative has been contributing to the promotion of scientific literacy and enrichment of the training path of young people, motivating them to deepen their knowledge and pursue higher studies in their areas of interest. (2019/05/03) Workshop (Member of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Current	Brain Awareness Week - Dissemination of Neuroscience Science to elementary and high school students under the Brain Awareness Week initiative created by the Dana Foundation, USA, which aims to raise awareness of the general public, including students, for the progress and benefit of brain study. (2021/03/15 - 2021/03/19) Seminar (Co-organisor)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/06/25 - 2024/06/29	Symposium of the FENS Forum 2024- "Diverse glial contribution to demyelination and Multiple Sclerosis" (2024/06/25 - 2024/06/29) Symposium (President of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/07 - 2023/07	SCIENTIFIC OCCUPATION OF YOUNG PEOPLE ON VACATION 2023, by Ciência Viva (2023/07 - 2023/07) Workshop (President of the Organising Committee)	Universidade de Lisboa Faculdade de Farmácia, Portugal Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2022/07 - 2022/07	SCIENTIFIC OCCUPATION OF YOUNG PEOPLE ON VACATION 2022, by Ciência Viva (2022/07 - 2022/07) Workshop (President of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07 - 2021/07	SCIENTIFIC OCCUPATION OF YOUNG PEOPLE ON VACATION 2021, by Ciência Viva (2021/07 - 2021/07) Workshop (President of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/11 - 2014/11	Profiling alterations in microglia dynamic properties by neuroinflammation (2014/11) Workshop	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/10 - 2012/10	Myelin: genesis, disease and repair (2012/10 - 2012/10) Symposium (President of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/02 - 2012/02	xCELLigence System On Your Campus (2012/02 - 2012/02) Workshop (President of the Organising Committee)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/12	Investigations of S100 proteins and their role in huntingtin aggregation (Thesis) Main arguer	Marta Sofia Silva da Cruz Botelho (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2023/12	Comparative Efficacy of CK1 Inhibitors and miRNA loaded Exosomes on the Recovery of ALS Injured Microglia (Thesis) Main arguer	Rita Jorge Barbosa (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/12	Mieloma Múltiplo: do Diagnóstico à Terapêutica Supervisor	Rita Margarida Madeira Gonçalves (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Terapêutica com células CAR-T: Novas Aplicações Terapêuticas em Doenças Hematológicas Supervisor	Carolina Miki Sakamoto Tasca (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	New in vitro model of microglia derived from human PBMCs to unravel their contribution in neurodegenerative disorders Supervisor	Inês Sofia Tomaz da Costa (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	O papel da microglia no desenvolvimento da Esclerose Múltipla Supervisor	Rita Alexandra Andrade da Cruz Soares Ramos (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Aplicação de nanopartículas metálicas no tratamento do cancro da próstata President of the jury	Sara Inês Bastos Pinho (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Contaminantes nos Alimentos - Microplásticos President of the jury	Mafalda Inês Domingos Potier (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Formulation, characterization and stability studies of emulsions containing different vegetable oils and caffeine as active compound President of the jury	Ana Margarida Colaço Dionísio (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/07	Investigation of novel compounds to prevent TrkB-FL cleavage (Thesis) Main arguer	Lia Marta Barreira Fernandes (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2023/06	Microglia depletion impact in epileptogenesis Focusing on NLRP3 inflammasome pathways (Thesis) Main arguer	Carolina Maria Vieira Capela (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/10	Developing molecular tools for the study of the STAT3 pathway (Thesis) Arguer	Ricardo Letra-Vilela (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/12/20	ROLE OF SP1 AND PADI2 ON OLIGODENDROCYTE DIFFERENTIATION ENHANCED BY MECHANOTRANSDUCTION (Thesis) Main arguer	Tânia Milene Pires Lourenço (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/12/19	Detection of age-associated changes of the targets of disease modifying therapies in Multiple Sclerosis Supervisor	Raquel Rei Pereira (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/12/13	Neuronal and behavioral alterations after intake of N-ethylpentylone in CD-1 Supervisor	Catarina Isabel Venda Grilo (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/07/20	Deadly Delivery: Unraveling the Contribution of Microglial Exosomes to Retinal Degeneration in Glaucoma (Thesis) Arguer	Inês Sofia Dinis Aires (PhD) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/07/04	Search for novel compounds to prevent TrkB-FL cleavage (Thesis) Main arguer	Sara Inteiro de Oliveira (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2022/06/03	Mechanical principles driving microglia activation (Thesis) Main arguer	Pedro Neves Melo (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/04/29	DIFFERENTIAL ROLE OF PGC-1a ISOFORMS IN THE MODULATION OF ASTROCYTES REACTIVE PHENOTYPE (Thesis) Main arguer	CARLOTA DE SÁ LEMOS GARCIA (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/12/10	Exploring cognition, 4-octyl itaconate treatment and clinical scoring in the animal model of Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis (Thesis) Main arguer	Maria Inês Portela de Melo (Master) Universidade do Porto Faculdade de Medicina, Portugal
2021/12/10	Can the extracellular vesicles released by Müller glial cells provide neuroprotection to retinal ganglion cells? (Thesis) Main arguer	Carolina Marques dos Santos (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/12/09	Development of new pharmacological approaches in ischemic stroke: A Systematic Review of transient MCAO model in rats. (Thesis) Arguer	João Solas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/11/09	Effects Of Newly Detected Synthetic Cathinones On The Central Nervous System Supervisor	Ana Margarida Barata Leitão (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07/19	Bacteriological etiology of Alzheimer’s Disease: Possibility of a vaccine? (Thesis) Main arguer	Alexandra Filipa Neves Gomes (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07/01	Characterization of BDNF signalling in the neonatal phencyclidine mouse model of schizophrenia (Thesis) Main arguer	Céline Felicidade Freitas (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/25	Characterization of the Cancer Antigen Release Profile of Nanoparticle-based Immunotherapy (Thesis) Arguer	Maria Machado Rodrigues González (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/06/25	Development of nanoparticle-based immunotherapy using chitosan as an immunomodulator (Thesis) Arguer	Pedro Lino Rosado (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/06/22	Unveiling the link between BDNF alterations and cognitive deficits in Schizophrenia (Thesis) Arguer	Sara Luísa Ramalho Tanqueiro (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/20	Determining the Cellular and Molecular Mechanisms Behind Glial Cell Phagocytosis (Thesis) Arguer	Lynn Nazareth (PhD) School of Pharmacy and Medical Science, Griffith Health, Griffith University, Australia
2021/03/22	Unravelling the contribution of glial cells for the neuroinflammatory milieu of epileptic-like organotypic slices (Thesis) Arguer	Mafalda Cagica Pinto de Carvalho (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/18	The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammationn Supervisor	Mafalda Manso (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/18	The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammation Supervisor	Mafalda Ferreira Manso (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/30	Organotypic brain slice cultures as a model to study supressors of Amyloid-ß toxicity relevant in Alzheimer’s Disease Supervisor	Francisco Schäller Dias (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/14	Neuronal miR-124 in Alzheimer's Disease human models: from cell functioning to trafficking (Thesis) Arguer	Henrique Paulino Sasso Pereira Mamede (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/12/17	Gene deletion and nanobodies strategies to target S100B and improve recovery in an ex vivo demyelinating model Supervisor	Alexandre Nunes Neto (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/12	Wound Healing: The role of Exosomes (Thesis) Main arguer	Júlia Carolina Lopes Matos (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/12	Linfoma de Hodgkin. Diagnóstico e terapêuticas atuais (Thesis) Main arguer	Nuno Manuel Cepeda da Silva (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11	Leucemia Linfocítica Crónica Diagnóstico e terapêutica: Novas abordagens (Thesis) Main arguer	Maria João Correia Goulart (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11	Mieloma Múltiplo: Diagnóstico e Terapêutica. Novos Marcadores da Doença (Thesis) Main arguer	Ana Margarida Murteira Damásio Boieiro Cotovio (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/06/05	Role of S100B in EAE pathogenesis Supervisor	Beatriz dos Santos Pinto Soromenho (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2020/02/17	Evaluating cortical transcriptomic differences between Alzheimer’s disease PSEN1-mutated mouse models and human patients, and their implications in drug development (Thesis) Arguer	Sara Rodrigues Mendes (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/21	TUNING CELL DEATH AND INFLAMMATION IN PARKINSON’S DISEASE (Thesis) Arguer	Pedro Dionísio (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/13	Characterization of blood markers and their implication in human aging (Thesis) Main arguer	Ainhoa Alberro Garitano (PhD) Universidad del País Vasco, Spain
2019/12/12	Impact of the Modulation of Tumor Vasculature on Cancer Vaccine Efficacy against Colorectal Cancer (Thesis) Arguer	Sandra Pena (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/19	Implication of induced Reelin-KO in the deposition of Aß plaques in Alzheimer´s Disease mouse models (Thesis) Main arguer	Rita Patrocínio (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/11/06	Vectored immunoprophylaxis to produce anti-BACE1 nanobodies for treatment of Alzheimer’s disease (Thesis) Main arguer	Eugénia Machado (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/10	MICROGLIA-MEDIATED REMODELLING OF THE CEREBELLAR CIRCUIT (Thesis) Main arguer	Pedro Ferreira (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/07/25	Dissecting pentraxin-3 role in the modulation of Multiple Sclerosis (Thesis) Main arguer	Joana Lima Sá (Master) Universidade do Minho Escola de Medicina, Portugal
2019/07/25	The potential role of innate immune memory in Multiple Sclerosis disease using autoimmune experimental encephalomyellitis mouse model (Thesis) Main arguer	Marta Monteiro (Master) Universidade do Minho Escola de Medicina, Portugal
2019/06/18	The calcium binding S100B protein as a new modulator of amyloid-ß peptide aggregation (Thesis) Arguer	Joana Cristóvão (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2019	UNVEILLING THE INTERPLAY BETWEEN ACTIVATED ASTROCYTES AND NEURONS IN AN IN VITRO MODEL OF ALZHEIMER’S DISEASE Supervisor	Ana Filipa da Costa Moreira (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Deciphering the involvement of S100B-RAGE axis in inflammation-associated myelin damage Supervisor	Gisela Filipa Assunção Santos (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Mechanisms of actin cytoskeletal dynamics in oligodendrocyte biology and myelin formation (Thesis) Main arguer	Maria Manuela Azevedo (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018	Targeting mitochondria-nucleus communication to improve aging-impaired neurogenesis (Thesis) Main arguer	Marcia Filipa Freire Dias da Costa (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Changes in Erythropoiesis and Transferrin Receptor 2 in Malaria-induced Anemia (Thesis) Main arguer	Ana Catarina Guilherme Pêgo (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	TARGETING MIR-124 IN MOTOR NEURONS AS A THERAPEUTIC STRATEGY TO PREVENT NEURODEGENERATION AND GLIAL ACTIVATION IN ALS (Thesis) Main arguer	Daniela Catarina Ribeiro Vizinha (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Role of adenosine A2A Receptors in Multiple Sclerosis: Neural Stem Cells as a potential target (Thesis) Main arguer	Ana Marta Alonso Gomes (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Astrocyte-specific Transcriptomic Response to PGC-1alpha Isoforms (Thesis) Main arguer	Mariana Messias de Jesus Rufino Ribeiro (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	S100B targeting to reduce demyelination and EAE pathogenesis Supervisor	Pedro Filipe Marques Pascoal (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	Visualization of STAT3 dimers in living cells (Thesis) Main arguer	Ana Catarina da Silva Almeida (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016	Role of microRNA in microglial phenotype during the progression of Alzheimer’s disease Supervisor	Mafalda Aurélio Monteiro (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015	Impact of Mechanotransduction in the Context of Central Nervous System Diseases (Thesis) Main arguer	Daniela Nogueira da Rocha Mar (PhD) Universidade do Porto Faculdade de Engenharia, Portugal
2015	Modulation of microglia reactivity by S100B in Multiple Sclerosis Supervisor	Carla Isabel Silveira Ferreira (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015	Exploring the modulatory role of A2A receptors in oligodendrogenesis derived from neural stem/progenitor cells of the subventricular zone (Thesis) Main arguer	Ana Iolanda d’Armada Moreira (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2014	Role of S100B on central nervous system demyelination and remyelination Supervisor	Vera Alexandra Padrela Martins Afonso (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014	Organotypic Hippocampal Slice Culture Model of Epileptogenesis: Electrophysiological and Molecular Features (Thesis) Main arguer	Noémia Marisa Felix Pereira (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2012	Bilirubin dysregulates myelination in early neonatal life Supervisor	Andreia Pereira Barateiro (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

	Society Organization name	Role
2016 - Current	Portuguese Glia Network	Outreach team
2008 - Current	Portuguese Society of Neurosciences
2008 - Current	Federation of European Neuroscience Societies
2002/04/01 - Current	Ordem dos Farmacêuticos

Conference scientific committee

	Conference name	Conference host
2019 - Current	XVI Meeting of the Portuguese Society for Neuroscience
2019 - Current	XIV European Meeting on Glial Cells in Health and Disease

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2022 - Current	Master Laboratory Medicine	Análises Clínicas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/07/06 - Current	Advances in Neuropharmaceutics	Farmácia	Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - Current	Master in Biochemistry	(Mestrado)	Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - Current	Master/PhD in Neurosciences	(Mestrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - Current	Master in Biopharmaceutical Sciences: Development and Organization of the Nervous System, Neuropathology and Neuropharmacology, Brain Barriers and Drug development, Physiopathology of Neuroinflammation (Regency).	(Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Current	Master in Pharmaceutical Chemistry and Therapeutics: Pharmaceutical Chemistry II	(Mestrado)
2009 - Current	Integrated master degree in Pharmaceutical Sciences: Anatomy, Biology Laboratory, Histology, Hematology.	master (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2020	Molecular Biomarkers and Technologies	Farmácia (Doutoramento)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016	PhD Programme GABBA	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2015	PhD Programme Human Genetics and Infectious Diseases	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Evaluation committee

	Activity description Role	Institution / Organization
2024 - Current	ERA4HEALTH_NUTRIBRAIN Evaluator
2023 - Current	MSCA POSTDOCTORAL FELLOWSHIPS 2023 Evaluator	European Commission, Belgium
2016 - Current	Alzheimer's Association – Call for Alzheimer's Association Research Grant (AARG) Evaluator
2015 - Current	Italian Ministry of Health, Scientific Research and Health Innovation - Call for Research
2014 - Current	MS Research Australia -Research projects Evaluator
2019 - 2019	Austrian Research Projects 2019 Evaluator	Fonds zur Förderung der wissenschaftlichen Forschung, Austria
2016 - 2016	Israel Science Foundation Evaluator	Israel Science Foundation, Israel
2015 - 2015	Medical Research Council, UK Evaluator	Medical Research Council, United Kingdom

Mentoring / Tutoring

	Topic	Student name
2024/02 - Current	Treatment of innovative human 3D brainspheres with pentamidine to tackle the role of S100B in human demyelination	annelore Douven
2023/01 - 2023/09	Role of glial cells in the pathogenesis of Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)	Elisa Farsetti
2022/10 - 2022/12	Characterization of iMG to a demyelinating insult	Paula Hebing

Distinctions

Award

2023	Portuguese call for research projects 2023 - BIOCODEX MICROBIOTA FOUNDATION
2022	ARSACS Project -2022-2023 Ataxia Canada, Canada
2017	Best Oral Communication at 4th International Porto Congress of Multiple Sclerosis Merck KGaA, Germany
2017	Grant for Multiple Sclerosis Innovation (GMSI) Merck & Co Inc, United States
2013	Bolsa Inovação da Secção Regional de Lisboa da Ordem dos Farmacêuticos Ordem dos Farmaceuticos, Portugal
2012	Edgar Cruz e Silva Prize Grupo de Estudo de Envelhecimento Cerebral e Demências (GEECD), Portugal
2011	Medal of Honor for Women in Science L’Oréal Fundação para a Ciência e a Tecnologia, Portugal UNESCO Office of International Standards and Legal Affairs, France Fondation L'Oréal, France
2007	EMBO short term felowship
2002	Programa Gulbenkian de Estímulo à Investigação Fundação Calouste Gulbenkian, Portugal