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Identification

Personal identification

Full name
Miquéias Lopes-Pacheco

Citation names

  • Lopes-Pacheco, Miquéias

Author identifiers

Ciência ID
2F19-B13D-89DF
ORCID iD
0000-0002-7444-9359
Google Scholar ID
RqRUGo8AAAAJ
Researcher Id
I-1290-2017
Scopus Author Id
55967922900

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Physiology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Projects

Contract

Designation Funders
2023/10/01 - 2025/09/30 Potentiation of R334W-CFTR Function by Novel Small Molecules
LOPES23G0
Principal investigator
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
 Cystic Fibrosis Foundation
Ongoing
Outputs

Publications

Journal article
  1. Filipa C. Ferreira; Margarida D. Amaral; Mafalda Bacalhau; Miquéias Lopes-Pacheco. "PTI-801 (posenacaftor) shares a common mechanism with VX-445 (elexacaftor) to rescue p.Phe508del-CFTR". European Journal of Pharmacology (2024): https://doi.org/10.1016/j.ejphar.2024.176390.
    10.1016/j.ejphar.2024.176390
  2. Filipa Ferreira; Camilla Buarque; Miquéias Lopes-Pacheco. "Organic Synthesis and Current Understanding of the Mechanisms of CFTR Modulator Drugs Ivacaftor, Tezacaftor, and Elexacaftor". Molecules (2024): https://doi.org/10.3390/molecules29040821.
    10.3390/molecules29040821
  3. Mafalda Bacalhau; Mariana Camargo; Miquéias Lopes-Pacheco. "Laboratory Tools to Predict CFTR Modulator Therapy Effectiveness and to Monitor Disease Severity in Cystic Fibrosis". Journal of Personalized Medicine (2024): https://doi.org/10.3390/jpm14010093.
    10.3390/jpm14010093
  4. Claudia C. dos Santos; Miquéias Lopes-Pacheco; Karen English; Sara Rolandsson Enes; Anna Krasnodembskaya; Patricia R. M. Rocco. "The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS". Cells (2024): https://doi.org/10.3390/cells13020122.
    10.3390/cells13020122
  5. L.Z. Salomão; R.A. Athanazio; S.Z. Rached; M. Lopes-Pacheco; M. Camargo. "A real-life study of elexacaftor-tezacaftor-ivacaftor therapy in people with cystic fibrosis in Brazil". Pulmonology (2023): https://doi.org/10.1016/j.pulmoe.2023.03.008.
    10.1016/j.pulmoe.2023.03.008
  6. Kathryn E. Oliver; Marianne S. Carlon; Nicoletta Pedemonte; Miquéias Lopes-Pacheco. "The revolution of personalized pharmacotherapies for cystic fibrosis: what does the future hold?". Expert Opinion on Pharmacotherapy (2023): https://doi.org/10.1080/14656566.2023.2230129.
    10.1080/14656566.2023.2230129
  7. Soraia Abreu; Leonardo Alves; Luiza Carvalho; Debora Xisto; Natália Blanco; Lígia Castro; Priscilla Olsen; et al. "Serum from patients with asthma potentiates macrophage phagocytosis and human mesenchymal stromal cell therapy in experimental allergic asthma". Cytotherapy (2023): https://doi.org/10.1016/j.jcyt.2023.05.014.
    10.1016/j.jcyt.2023.05.014
  8. Miquéias Lopes-Pacheco; Patricia R. M. Rocco. "Functional enhancement strategies to potentiate the therapeutic properties of mesenchymal stromal cells for respiratory diseases". Frontiers in Pharmacology 14 (2023): http://dx.doi.org/10.3389/fphar.2023.1067422.
    10.3389/fphar.2023.1067422
  9. Mafalda Bacalhau; Mariana Camargo; Grace A. V. Magalhães-Ghiotto; Sybelle Drumond; Carlos Henrique M. Castelletti; Miquéias Lopes-Pacheco. "Elexacaftor-Tezacaftor-Ivacaftor: A Life-Changing Triple Combination of CFTR Modulator Drugs for Cystic Fibrosis". Pharmaceuticals (2023): https://doi.org/10.3390/ph16030410.
    10.3390/ph16030410
  10. Mafalda Bacalhau; Filipa C. Ferreira; Iris A. L. Silva; Camilla D. Buarque; Margarida D. Amaral; Miquéias Lopes-Pacheco. "Additive Potentiation of R334W-CFTR Function by Novel Small Molecules". Journal of Personalized Medicine (2023): https://doi.org/10.3390/jpm13010102.
    10.3390/jpm13010102
  11. Iris A. L. Silva; Onofrio Laselva; Miquéias Lopes-Pacheco. "Advances in Preclinical In Vitro Models for the Translation of Precision Medicine for Cystic Fibrosis". Journal of Personalized Medicine (2022): https://doi.org/10.3390/jpm12081321.
    10.3390/jpm12081321
  12. Denise Battaglini; Miquéias Lopes-Pacheco; Hugo C. Castro-Faria-Neto; Paolo Pelosi; Patricia R. M. Rocco. "Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19". Frontiers in Immunology 13 (2022): https://doi.org/10.3389%2Ffimmu.2022.857573.
    10.3389/fimmu.2022.857573
  13. Sang Hyun Lim; Jamie Snider; Liron Birimberg-Schwartz; Wan Ip; Joana C Serralha; Hugo M Botelho; Miquéias Lopes-Pacheco; et al. "CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system". Molecular Systems Biology 18 2 (2022): e10629. https://doi.org/10.15252/msb.202110629.
    Published • 10.15252/msb.202110629
  14. Miquéias Lopes-Pacheco; Mafalda Bacalhau; Sofia S. Ramalho; Iris A. L. Silva; Filipa C. Ferreira; Graeme W. Carlile; David Y. Thomas; et al. "Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A". Cells 11 1 (2022): 136. https://doi.org/10.3390/cells11010136.
    Published • 10.3390/cells11010136
  15. Bacalhau, Mafalda; Ferreira, Ana Filipa C.; Souza, Filipe R.; Kmit, Arthur; da Silva, Verônica D.; Pimentel, André S.; Amaral, Margarida D.; et al. "Identification of novel F508del-CFTR traffic correctors among triazole derivative compounds". Biochemical Pharmacology (2022): https://doi.org/10.1016/j.ejphar.2022.175396.
    Submitted • 10.1016/j.ejphar.2022.175396
  16. Miquéias Lopes-Pacheco; Nicoletta Pedemonte; Guido Veit. "Discovery of CFTR modulators for the treatment of cystic fibrosis". Expert Opinion on Drug Discovery 16 8 (2021): 897-913. https://doi.org/10.1080/17460441.2021.1912732.
    10.1080/17460441.2021.1912732
  17. Madalena C Pinto; Iris AL Silva; Miriam F Figueira; Margarida D Amaral; Miquéias Lopes-Pacheco. "Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis". Journal of Experimental Pharmacology 13 (2021): 693-723. https://doi.org/10.2147/JEP.S255377.
    10.2147/JEP.S255377
  18. Kátia Nunes da Silva; André Luiz Nunes Gobatto; Zaquer Suzana Munhoz Costa-Ferro; Bruno Raphael Ribeiro Cavalcante; Alex Cleber Improta Caria; Luciana Souza de Aragão França; Carolina Kymie Vasques Nonaka; et al. "Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19?". Stem Cell Research & Therapy 12 1 (2021): 425. https://doi.org/10.1186%2Fs13287-021-02502-7.
    10.1186/s13287-021-02502-7
  19. Lúcia Santos; Karen Mention; Kader Cavusoglu-Doran; David J. Sanz; Mafalda Bacalhau; Miquéias Lopes-Pacheco; Patrick T Harrison; Carlos M Farinha. "Comparison of Cas9 and Cas12a CRISPR editing methods to correct the W1282X-CFTR mutation". Journal of Cystic Fibrosis 21 1 (2021): 181-187. https://doi.org/10.1016%2Fj.jcf.2021.05.014.
    10.1016/j.jcf.2021.05.014
  20. Mariana A. Antunes; Cassia L. Braga; Tainá B. Oliveira; Jamil Z. Kitoko; Ligia L. Castro; Debora G. Xisto; Mariana S. Coelho; et al. "Mesenchymal Stromal Cells From Emphysematous Donors and Their Extracellular Vesicles Are Unable to Reverse Cardiorespiratory Dysfunction in Experimental Severe Emphysema". Frontiers in Cell and Developmental Biology 9 (2021): 661385. https://doi.org/10.3389%2Ffcell.2021.661385.
    10.3389/fcell.2021.661385
  21. Luiza Rachel Pinheiro de Carvalho; Soraia Carvalho Abreu; Ligia Lins de Castro; Luísa Helena Andrade da Silva; Paula Matos Silva; Juliana Borges Vieira; Renata Trabach Santos; et al. "Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis*". Critical Care Medicine 49 9 (2021): e880-e890. https://doi.org/10.1097%2Fccm.0000000000005056.
    10.1097/ccm.0000000000005056
  22. Antunes, Mariana Alves; Lopes-Pacheco, Miquéias; Rocco, Patricia R.M.. "Oxidative Stress-derived Mitochondrial Dysfunction in Chronic Pulmonary Obstructive Disease: A Concise Review". Oxidative Medicine and Cellular Longevity (2021): https://doi.org/10.1155/2021/6644002.
    Open access • Published • 10.1155/2021/6644002
  23. Abreu, Soraia C.; Lopes-Pacheco, Miquéias; Weiss, Daniel J.; Rocco, Patricia R. M.. "Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives". Frontiers in Cell and Developmental Biology 9 (2021): 600711. http://dx.doi.org/10.3389/fcell.2021.600711.
    Open access • Published • 10.3389/fcell.2021.600711
  24. Lopes-Pacheco, Miquéias; Silva, Pedro Leme; Cruz, Fernanda Ferreira; Battaglini, Denise; Robba, Chiara; Pelosi, Paolo; Morales, Marcelo Marcos; Caruso Neves, Celso; Rocco, Patricia Rieken Macedo. "Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies". Frontiers in Physiology 12 (2021): 593223. http://dx.doi.org/10.3389/fphys.2021.593223.
    Open access • Published • 10.3389/fphys.2021.593223
  25. Miquéias Lopes-Pacheco; Iris A.L. Silva; Mark J. Turner; Graeme W. Carlile; Elvira Sondo; David Y. Thomas; Nicoletta Pedemonte; John W. Hanrahan; Margarida D. Amaral. "Characterization of the mechanism of action of RDR01752, a novel corrector of F508del-CFTR". Biochemical Pharmacology 180 (2020): 114133-114133. https://doi.org/10.1016%2Fj.bcp.2020.114133.
    Published • 10.1016/j.bcp.2020.114133
  26. Fabio S. Aguiar; André S. Melo; Ana Maria S. Araújo; Alexandre P. Cardoso; Sergio Augusto L. de Souza; Miquéias Lopes-Pacheco; Fernanda F. Cruz; et al. "Autologous bone marrow-derived mononuclear cell therapy in three patients with severe asthma". Stem Cell Research & Therapy 11 1 (2020): https://doi.org/10.1186%2Fs13287-020-01675-x.
    Published • 10.1186/s13287-020-01675-x
  27. Miquéias Lopes-Pacheco. "CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine". Frontiers in Pharmacology 10 (2020): 1662. https://doi.org/10.3389/fphar.2019.01662.
    Open access • Published • 10.3389/fphar.2019.01662
  28. Castro, L.L.; Kitoko, J.Z.; Xisto, D.G.; Olsen, P.C.; Guedes, H.L.M.; Morales, M.M.; Lopes-Pacheco, M.; Cruz, F.F.; Rocco, P.R.M.. "Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma". Stem Cells Translational Medicine 9 2 (2020): 250-260. https://doi.org/10.1002/sctm.19-0120.
    Open access • Published • 10.1002/sctm.19-0120
  29. Lopes-Pacheco, M.; Robba, C.; Rocco, P.R.M.; Pelosi, P.. "Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome". Cell Biology and Toxicology 36 1 (2020): 83-102. https://doi.org/10.1007/s10565-019-09493-5.
    Published • 10.1007/s10565-019-09493-5
  30. Lopes-Pacheco, M.; Pedemonte, N.; Kicic, A.. "Editorial: Emerging therapeutic approaches for cystic fibrosis". Frontiers in Pharmacology 10 (2019): 1440. https://doi.org/10.3389/fphar.2019.01440.
    Open access • Published • 10.3389/fphar.2019.01440
  31. Johnatas D. Silva; Ligia L. de Castro; Cassia L. Braga; Gisele P. Oliveira; Stefano A. Trivelin; Carlos M. Barbosa-Junior; Marcelo M. Morales; et al. "Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology". Stem Cells International 2019 (2019): 8262849. https://doi.org/10.1155/2019/8262849.
    Open access • Published • 10.1155/2019/8262849
  32. Silva, J.D.; Lopes-Pacheco, M.; De Castro, L.L.; Kitoko, J.Z.; Trivelin, S.A.; Amorim, N.R.; Capelozzi, V.L.; et al. "Eicosapentaenoic acid potentiates the therapeutic effects of adipose tissue-derived mesenchymal stromal cells on lung and distal organ injury in experimental sepsis". Stem Cell Research and Therapy 10 1 (2019): 264. https://doi.org/10.1186/s13287-019-1365-z.
    Open access • Published • 10.1186/s13287-019-1365-z
  33. de Castro, L.L.; Lopes-Pacheco, M.; Weiss, D.J.; Cruz, F.F.; Rocco, P.R.M.. "Current understanding of the immunosuppressive properties of mesenchymal stromal cells". Journal of Molecular Medicine 97 5 (2019): 605-618. https://doi.org/10.1007/s00109-019-01776-y.
    Published • 10.1007/s00109-019-01776-y
  34. Soraia C. Abreu; Debora G. Xisto; Tainá B. de Oliveira; Natalia G. Blanco; Lígia Lins de Castro; Jamil Zola Kitoko; Priscilla C. Olsen; et al. "Serum from Asthmatic Mice Potentiates the Therapeutic Effects of Mesenchymal Stromal Cells in Experimental Allergic Asthma". STEM CELLS Translational Medicine 8 3 (2019): 301-312. https://doi.org/10.1002/sctm.18-0056.
    Open access • Published • 10.1002/sctm.18-0056
  35. Waseema Patel; Patrick J. Moore; M. Flori Sassano; Miquéias Lopes-Pacheco; Andrei A. Aleksandrov; Margarida D. Amaral; Robert Tarran; Michael A. Gray. "Increases in cytosolic Ca2+ induce dynamin- and calcineurin-dependent internalisation of CFTR". Cellular and Molecular Life Sciences 76 5 (2019): 977-994. https://doi.org/10.1007/s00018-018-2989-3.
    Published • 10.1007/s00018-018-2989-3
  36. Hananda A. Poggio; Mariana A. Antunes; Nazareth N. Rocha; Jamil Z. Kitoko; Marcelo M. Morales; Priscilla C. Olsen; Miquéias Lopes-Pacheco; Fernanda F. Cruz; Patricia R. M. Rocco. "Impact of one versus two doses of mesenchymal stromal cells on lung and cardiovascular repair in experimental emphysema". Stem Cell Research & Therapy 9 1 (2018): 296. https://doi.org/10.1186/s13287-018-1043-6.
    Open access • Published • 10.1186/s13287-018-1043-6
  37. Miquéias Lopes-Pacheco; Jamil Zola Kitoko; Marcelo M. Morales; Hilda Petrs-Silva; Patricia Rieken Macêdo Rocco. "Self-complementary and tyrosine-mutant rAAV vectors enhance transduction in cystic fibrosis bronchial epithelial cells". Experimental Cell Research 372 2 (2018): 99-107. https://doi.org/10.1016/j.yexcr.2018.09.015.
    Published • 10.1016/j.yexcr.2018.09.015
  38. Mariana Alves Bellezzia; Fernanda F Cruz; Vanessa Martins; Lígia Lins de Castro; Miquéias Lopes-Pacheco; Eduardo Prata Vilanova; Paulo A Mourão; Patricia RM Rocco; Pedro L Silva. "Impact of different intratracheal flows during lung decellularization on extracellular matrix composition and mechanics". Regenerative Medicine 13 5 (2018): 519-530. https://doi.org/10.2217/rme-2018-0008.
    Published • 10.2217/rme-2018-0008
  39. Soraia Carvalho Abreu; Miquéias Lopes-Pacheco; Adriana Lopes da Silva; Debora Gonçalves Xisto; Tainá Batista de Oliveira; Jamil Zola Kitoko; Lígia Lins de Castro; et al. "Eicosapentaenoic Acid Enhances the Effects of Mesenchymal Stromal Cell Therapy in Experimental Allergic Asthma". Frontiers in Immunology 9 (2018): 1147. https://doi.org/10.3389%2Ffimmu.2018.01147.
    Open access • Published • 10.3389/fimmu.2018.01147
  40. M.A.S. Malaquias; L.A. Oyama; P.C. Jericó; I. Costa; G. Padilha; S. Nagashima; M. Lopes-Pacheco; et al. "Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance in a murine model of asthma". Allergologia et Immunopathologia 46 2 (2018): 136-143. https://doi.org/10.1016/j.aller.2017.06.003.
    Published • 10.1016/j.aller.2017.06.003
  41. Silva, J.D.; Lopes-Pacheco, M.; Paz, A.H.R.; Cruz, F.F.; Melo, E.B.; de Oliveira, M.V.; Xisto, D.G.; et al. "Mesenchymal Stem Cells From Bone Marrow, Adipose Tissue, and Lung Tissue Differentially Mitigate Lung and Distal Organ Damage in Experimental Acute Respiratory Distress Syndrome". Critical Care Medicine 46 2 (2018): e132-e140. https://doi.org/10.1097/ccm.0000000000002833.
    Published • 10.1097/CCM.0000000000002833
  42. Helena D’Anunciação de Oliveira; Elga Bernardo Bandeira de Melo; Johnatas Dutra Silva; Jamil Zola Kitoko; Bianca Gutfilen; Thiago Barboza; Sergio Augusto Lopes de Souza; et al. "Therapeutic effects of bone marrow-derived mononuclear cells from healthy or silicotic donors on recipient silicosis mice". Stem Cell Research & Therapy 8 1 (2017): 259. https://doi.org/10.1186/s13287-017-0699-7.
    Open access • Published • 10.1186/s13287-017-0699-7
  43. Miquéias Lopes-Pacheco; Clément Boinot; Inna Sabirzhanova; Daniele Rapino; Liudmila Cebotaru. "Combination of Correctors Rescues CFTR Transmembrane-Domain Mutants by Mitigating their Interactions with Proteostasis". Cellular Physiology and Biochemistry 41 6 (2017): 2194-2210. https://doi.org/10.1159/000475578.
    Open access • Published • 10.1159/000475578
  44. Miquéias Lopes-Pacheco. "CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis". Frontiers in Pharmacology 7 (2016): 275. https://doi.org/10.3389/fphar.2016.00275.
    Open access • Published • 10.3389/fphar.2016.00275
  45. Isabela Henriques; Miquéias Lopes-Pacheco; Gisele A. Padilha; Patrícia S. Marques; Raquel F. Magalhães; Mariana A. Antunes; Marcelo M. Morales; et al. "Moderate Aerobic Training Improves Cardiorespiratory Parameters in Elastase-Induced Emphysema". Frontiers in Physiology 7 (2016): 329. https://doi.org/10.3389/fphys.2016.00329.
    Open access • Published • 10.3389/fphys.2016.00329
  46. Elga Bandeira; Miquéias Lopes-Pacheco; Nadia Chiaramoni; Débora Ferreira; Maria J. Fernandez-Ruocco; Maria J. Prieto; Tatiana Maron-Gutierrez; et al. "Association with Amino Acids Does Not Enhance Efficacy of Polymerized Liposomes As a System for Lung Gene Delivery". Frontiers in Physiology 7 (2016): 151. https://doi.org/10.3389/fphys.2016.00151.
    Open access • Published • 10.3389/fphys.2016.00151
  47. Lopes-Pacheco, Miquéias. "Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis". ChemBioChem 17 6 (2016): 493-505. https://doi.org/10.1002/cbic.201500620.
    Published • 10.1002/cbic.201500620
  48. Fernanda Ferreira Cruz; Lucas Felipe Bastos Horta; Lígia de Albuquerque Maia; Miquéias Lopes-Pacheco; André Benedito da Silva; Marcelo Marco Morales; Cassiano Felippe Gonçalves-de-Albuquerque; et al. "Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis". PLoS ONE 11 1 (2016): e0147005. https://doi.org/10.1371/journal.pone.0147005.
    Open access • Published • 10.1371/journal.pone.0147005
  49. Miquéias Lopes-Pacheco; Elga Bandeira; Marcelo M. Morales. "Cell-Based Therapy for Silicosis". Stem Cells International 2016 (2016): 5091838. https://doi.org/10.1155/2016/5091838.
    Open access • Published • 10.1155/2016/5091838
  50. Lopes-Pacheco, Miquéias; Boinot, Clément; Sabirzhanova, Inna; Morales, Marcelo M.; Guggino, William B.; Cebotaru, Liudmila. "Combination of Correctors Rescue ¿F508-CFTR by Reducing Its Association with Hsp40 and Hsp27". Journal of Biological Chemistry 290 42 (2015): 25636-25645. https://doi.org/10.1074/jbc.m115.671925.
    Published • 10.1074/jbc.m115.671925
  51. Gisele A. Padilha; Isabela Henriques; Miquéias Lopes-Pacheco; Soraia C. Abreu; Milena V. Oliveira; Marcelo M. Morales; Lidia M. Lima; et al. "Therapeutic effects of LASSBio-596 in an elastase-induced mouse model of emphysema". Frontiers in Physiology 6 (2015): 267. https://doi.org/10.3389/fphys.2015.00267.
    Open access • Published • 10.3389/fphys.2015.00267
  52. Marcelo M. Morales; Sérgio A. L. Souza; Luiz Paulo Loivos; Marina A. Lima; Amir Szklo; Leandro Vairo; Taís H. K. Brunswick; et al. "Pilot safety study of intrabronchial instillation of bone marrow-derived mononuclear cells in patients with silicosis". BMC Pulmonary Medicine 15 (2015): 66. https://doi.org/10.1186/s12890-015-0061-8.
    Published • 10.1186/s12890-015-0061-8
  53. Daniele Rapino; Inna Sabirzhanova; Miquéias Lopes-Pacheco; Rahul Grover; William B. Guggino; Liudmila Cebotaru; Klaus Brusgaard. "Rescue of NBD2 Mutants N1303K and S1235R of CFTR by Small-Molecule Correctors and Transcomplementation". PLoS ONE 10 3 (2015): e0119796. https://doi.org/10.1371/journal.pone.0119796.
    Open access • Published • 10.1371/journal.pone.0119796
  54. Sabirzhanova, I.; Lopes Pacheco, M.; Rapino, D.; Grover, R.; Handa, J.T.; Guggino, W.B.; Cebotaru, L.; et al. "Rescuing trafficking mutants of the ATP-binding cassette protein, ABCA4, with small molecule correctors as a treatment for Stargardt eye disease". Journal of Biological Chemistry 290 32 (2015): 19743-19755. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939178528&partnerID=MN8TOARS.
    Published • 10.1074/jbc.M115.647685
  55. Lopes-Pacheco, Miquéias; Ventura, Túlio G.; de Oliveira, Helena D'Anunciação; Monção-Ribeiro, Leonardo C.; Gutfilen, Bianca; de Souza, Sergio A. L.; Rocco, Patrícia R. M.; et al. "Infusion of Bone Marrow Mononuclear Cells Reduces Lung Fibrosis but Not Inflammation in the Late Stages of Murine Silicosis". PLoS ONE 9 10 (2014): e109982. http://dx.doi.org/10.1371/journal.pone.0109982.
    Published • 10.1371/journal.pone.0109982
  56. Mariana A Antunes; Soraia C Abreu; Fernanda F Cruz; Ana Clara Teixeira; Miquéias Lopes-Pacheco; Elga Bandeira; Priscilla C Olsen; et al. "Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema". Respiratory Research 15 1 (2014): 118. https://doi.org/10.1186/s12931-014-0118-x.
    Open access • Published • 10.1186/s12931-014-0118-x
  57. Johnatas D. Silva; Bruno D. Paredes; Indianara M. Araújo; Miquéias Lopes-Pacheco; Milena V. Oliveira; Grazielle D. Suhett; Lanuza A. P. Faccioli; et al. "Effects of Bone Marrow-Derived Mononuclear Cells From Healthy or Acute Respiratory Distress Syndrome Donors on Recipient Lung-Injured Mice". Critical Care Medicine 42 7 (2014): e510-e524. https://doi.org/10.1097/ccm.0000000000000296.
    Published • 10.1097/ccm.0000000000000296
  58. Sabrina V. Martini; Adriana L. da Silva; Debora Ferreira; Karina Gomes; Felipe M. Ornellas; Miquéias Lopes-Pacheco; Emilia Zin; et al. "Single Tyrosine Mutation in AAV8 Vector Capsid Enhances Gene Lung Delivery and Does Not Alter Lung Morphofunction in Mice". Cellular Physiology and Biochemistry 34 3 (2014): 681-690. https://doi.org/10.1159/000363033.
    Open access • Published • 10.1159/000363033
  59. Miquéias Lopes-Pacheco; Debora G. Xisto; Felipe M. Ornellas; Mariana A. Antunes; Soraia C. Abreu; Patricia R.M. Rocco; Christina M. Takiya; Marcelo M. Morales. "Repeated Administration of Bone Marrow-Derived Cells Prevents Disease Progression in Experimental Silicosis". Cellular Physiology and Biochemistry 42 7 (2013): 1681-1694. https://doi.org/10.1097/ccm.0000000000000296.
    Open access • Published • 10.1159/000356603
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017/05/07 CFTR Modulators: Shedding Light of Precision Medicine for Cystic Fibrosis VI Multidisciplinar Brazilian Conference of Cystic Fibrosis
Brazilian Cystic Fibrosis Study Group (Curitiba, Brazil)
2015/05/02 Correctors Rescue CFTR Mutations in NBD1 Through a Proteostatic Network of Proteins V Multidisciplinar Brazilian Conference of Cystic Fibrosis
Brazilian Cystic Fibrosis Study Group (Gramado, Brazil)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09/01 - Current Identification of Corrector Combinations to Increase the Rescue of F508del-CFTR Traffic
Supervisor
 Medical Biochemistry (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2022/03/05 - 2022/07/05 Rescue of rare class II CFTR mutants by novel small-molecule correctors
Supervisor
 Biotechnology (Other)
Università degli Studi di Foggia, Italy
2022/03/01 - 2022/07/01 Rescue of rare misfolding CFTR mutants by small-molecule correctors
Supervisor
 Biotechnical Faculty (Other)
Univerza v Ljubljani, Slovenia
2021/05 - 2021/09 Rescue of rare misfolding CFTR mutants by small-molecule correctors
Supervisor
 Bioquímica (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2016 Therapeutic effects of bone marrow- and adipose tissue-derived mesenchymal stromal cells in experimental asthma
Co-supervisor
 Biological Sciences (Biophysics) (Master)
Universidade Federal do Rio de Janeiro, Brazil
2015 - 2016 Impact of one versus two doses of mesenchymal stromal cells on lung and cardiovascular repair in experimental emphysema
Co-supervisor
 Medicine (Degree)
Universidade Federal do Estado do Rio de Janeiro, Brazil
2014/08 - 2015/07 Therapeutic effects of bone marrow-derived mononuclear cells from healthy or silicotic donors on recipient silicosis mice
Co-supervisor
 Biological Sciences (Physiology) (Master)
Universidade Federal do Rio de Janeiro, Brazil
2011/08/01 - 2012/06/30 Pharmacological treatments for patients with type 2 diabetes
Co-supervisor
 Pharmaceutical Sciences (Degree)
Universidade Presidente Antônio Carlos Juiz de Fora, Brazil

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/01/31 Investigation of the genotypic profile of cystic fibrosis patients in a mixed population of the Middle-West of Brazil
(Thesis) Main arguer
 Letícia de Souza Pereira (Master)
Universidade Estadual de Goiás, Brazil
2014/11 Importance of folic acid in the formation of the neural tube
(Thesis) Main arguer
 Giselle Aquino Martins (Other)
Universidade Presidente Antônio Carlos Juiz de Fora, Brazil

Association member

Society Organization name Role
2021/07/01 - Current Portuguese Society of Biochemistry Regular member
2018 - Current European Respiratory Society (ERS) Regular member
2018 - Current Portuguese Society of Pneumology (SPP) Regular member
2014 - Current Associação Brasileira de Terapia Celular e Gênica (ABTCel-Gen) Regular member
2011 - Current Brazilian Society of Biophysics (SBBf) Regular member
2022 - 2024 European Cystic Fibrosis Society Regular member

Committee member

Activity description
Role 		Institution / Organization
2022 - 2024 Scientific Committee Member (within Cell Biology/Physiology assembly) of the European Cysitic Fibrosis Society Conference
Member
 European Cystic Fibrosis Society, Denmark
2021/08/06 - 2021/08/07 Technical-Scientifica Member of the II Brazilian Interdisciplinary Symposium of CF Instituto Unidos Pela Vida, Brazil
2020/11/20 - 2020/11/21 Technical-Scientific Member of the I Brazilian Interdisciplinary Symposium of CF
Member
 Instituto Unidos Pela Vida, Brazil

Conference scientific committee

Conference name Conference host
2017/05/01 - 2017/05/04 VII Multidisciplinar Brazilian Conference of Cystic Fibrosis Curitiba, Paraná, Brazil

Consulting

Activity description Institution / Organization
2017 - 2017 Incentive Award in Science, Technology and Innovation for the Unified Health System (SUS) 2017 Department of Science and Technology/Ministry of Health (Brazil), Brazil

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2019/04/19 Miquéias Lopes-Pacheco: The Brazilian CF Researcher And Traveler Proteostasis Therapeutic - For Patients & Families
2017/04 A proteína CFTR e seus moduladores Unidos Pela Vida - Instituto Brasileiro de Atenção a Fibrose Cística

Journal scientific committee

Journal title (ISSN) Publisher
2022 - Current Journal of Personalized Medicine (2075-4426) Multidisciplinary Digital Publishing Institute
2021/03/23 - Current Current Pharmacogenomics and Personalized Medicine (1875-6921) Benthan Science
2021/02 - Current Expert Opinion On Pharmacotherapy (1465-6566) Taylor & Francis
2021/02 - Current Frontiers in Cellular and Infection Microbiology Frontiers Media S.A.
2021/02 - Current Internation Journal of Molecular Sciences (1422-0067) Multidisciplinary Digital Publishing Institute
2021/01 - Current Life (2075-1729) Multidisciplinary Digital Publishing Institute
2020/10 - Current Stem Cells International (1687-9678) Hindawi Publishing Corporation (Sage-Hindawi Access to Research)
2020/08/08 - Current Frontiers in Immunology (1664-3224) Frontiers Media SA
2020/04 - Current BMJ Open (2044-6055) BMJ
2020/03 - Current Journal of Translational Medicine (1479-5876) Springer (Biomed Central Ltd.)
2020/03 - Current Lung (1432-1750) Springer-Verlag
2020/02 - Current Stem Cell Research & Therapy (1757-6512) Springer (Biomed Central Ltd.)
2019/12 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2019/09 - Current Stem Cells Translational Medicine (2157-6580) Wiley (John Wiley & Sons)
2018/06 - Current Molecular Biology Reports (1573-4978) Springer-Verlag
2018/05 - Current Frontiers in Pharmacology (1663-9812) Frontiers Media SA
2018/03 - Current Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2018/03 - Current Journal of Molecular Medicine (1432-1440) Springer-Verlag
2017/06 - Current Biochemical Pharmacology (0006-2952) Elsevier
2016/06 - Current British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
2016/04 - Current International Journal of Immunopathology and Pharmacology (0394-6320) SAGE Publications
2016/04 - Current Respiratory Research (1465-9921) Springer (Biomed Central Ltd.)
2016/02 - Current Journal of Thoracic Disease (2077-6624) AME Publishing Company
Distinctions

Award

2021 Path to a Cure Award
Cystic Fibrosis Foundation, United States
2018 Award in the Research Scholars Program in Cystic Fibrosis
Gilead Sciences Inc, United States
2016 2016 Cells Travel Award
Multidisciplinary Digital Publishing Institute AG, Switzerland
2012 RSF - ATS Travel Award
American Thoracic Society, United States

Other distinction

2023 World Top 2% Cited Scientists (single year 2022)
Stanford University, United States
2022 World Top 2% Cited Scientists (single year 2021)
Stanford University, United States
2021 World Top 2% Cited Scientists (single year 2020)
Stanford University, United States
2012 Honorable Mention
2011 Best Poster Presentation