???global.info.a_carregar???
Carlos F. M. Silva was born in Vila Nova de Gaia (Portugal) in 1993. He graduated in Biochemistry from the University of Aveiro in July 2014. Then, he followed his master studies in the same institution having concluded the degree in December 2016. In Feb 2023, he received his Ph.D. in Sustainable Chemistry, with honors and distinction, from the University of Aveiro, under the supervision of Full Professor Artur M. S. Silva (University of Aveiro) and Doctor Pedro A. Fernandes (University of Porto). During his Ph.D., he was involved in the guidance of 5 students in the Final Project of the Bachelor's Degree (including 2 ERASMUS students), 1 student in the Master's final thesis and 1 student in a extracurricular project. Published 7 articles in peer-review SCI international journals (h-index 5, 120 citations) and one book chapters. He participated in several National and International scientific conferences, having presented 9 oral communications and 6 panel communications.
Read full resume ↓
Identification

Personal identification

Full name
Carlos Fábio Magalhães da Silva

Citation names

  • Silva, Carlos F. M.

Author identifiers

Ciência ID
2F1A-B4DB-B7E1
ORCID iD
0000-0002-4538-1527

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/04/01 - 2023/02/28
Concluded
 Química Sustentável (Doutoramento)
Major in Química Medicinal
Universidade de Aveiro, Portugal

Universidade do Porto, Portugal
"Design, synthesis and evaluation of novel potential antileishmanial agents" (THESIS/DISSERTATION)
 Honors and distinction
2014/09 - 2016/12
Concluded
 Bioquímica (Mestrado)
Major in Bioquímica Clínica
Universidade de Aveiro, Portugal
"Synthesis and biological evaluation of new 2-benzylchromones" (THESIS/DISSERTATION)
 17
2011/09 - 2014/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Aveiro, Portugal
"2–benzylchromones: Synthesis of new acetylcholinesterase inhibitors" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2022/05/15 - 2022/11/15 Researcher (Research) Universidade de Aveiro, Portugal
Projects

Contract

Designation Funders
2019/12/01 - 2023/11/30 Development of new inhibitors of invasive osteosarcoma based on fisetin derivatives
PTDC/MED-QUI/29243/2017
10.54499/PTDC/MED-QUI/29243/2017
Universidade de Aveiro, Portugal

Universidade do Porto, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Química Orgânica, Produtos Naturais e Agroalimentares
UID/QUI/00062/2019
Universidade de Aveiro, Portugal

Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Silva, Carlos; Batista, Vasco F.; Pinto, Diana Cláudia Gouveia Alves; Silva, Artur. "Synthesis of dihydroquinolines in the XXI century". In Synthetic Approaches to Nonaromatic Nitrogen Heterocycles. 2020.
    In press
Journal article
  1. Carlos F. M. Silva; Ana P. D. de M. S. Guerrinha; Sofia Carvalho; Diana C. G. A. Pinto; Artur M. S. Silva. "1,3,5-Triazine: A Promising Molecular Scaffold for Novel Agents for the Treatment of Alzheimer’s Disease". International Journal of Molecular Sciences (2025): https://doi.org/10.3390/ijms26030882.
    10.3390/ijms26030882
  2. Benramdane, Hanane; Benariba, Nabila; Silva, Carlos F. M.; Catarino, Marcelo D.; Bartolomeu, Maria D.; Zohra Fekhikher, Zohra F; Pinto, Diana. "Phytochemical Profile, Antioxidant, Anti-Alzheimer, And a-Glucosidase Inhibitory Effect Of Algerian Peganum harmala Seeds Extract". Chemistry & Biodiversity (2024): http://dx.doi.org/10.1002/cbdv.202401308.
    10.1002/cbdv.202401308
  3. Fatima Ezzahra Laghchioua; Carlos F. M. da Silva; Diana C. G. A. Pinto; José A. S. Cavaleiro; Ricardo F. Mendes; Filipe A. Almeida Paz; Maria A. F. Faustino; et al. "Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights". ACS Chemical Neuroscience (2024): https://doi.org/10.1021/acschemneuro.4c00241.
    10.1021/acschemneuro.4c00241
  4. Carlos F. M. Silva; Diana C. G. A. Pinto; Pedro A. Fernandes; Artur M. S. Silva. "Evolution of the Quinoline Scaffold for the Treatment of Leishmaniasis: A Structural Perspective". Pharmaceuticals (2024): https://doi.org/10.3390/ph17030285.
    10.3390/ph17030285
  5. Letícia D. Costa; Carlos F.M. Silva; Diana C.G.A. Pinto; Artur M.S. Silva; Florbela Pereira; Maria Amparo F. Faustino; Augusto C. Tomé. "Discovery of thiazolo[5,4-c]isoquinoline based compounds as acetylcholinesterase inhibitors through computational target prediction, molecular docking and bioassay". Journal of Molecular Structure (2023): https://doi.org/10.1016/j.molstruc.2023.136088.
    10.1016/j.molstruc.2023.136088
  6. Carlos F. M. Silva; Teresa Leão; Filipa Dias; Ana M. Tomás; Diana C. G. A. Pinto; Eduardo F. T. Oliveira; Ana Oliveira; Pedro A. Fernandes; Artur M. S. Silva. "Structure-Activity Relationship Studies of 9-Alkylamino-1,2,3,4-tetrahydroacridines against Leishmania (Leishmania) infantum Promastigotes". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020669.
    10.3390/pharmaceutics15020669
  7. Carlos Fábio Magalhães da Silva; Pinto, DCGA; Pedro Alexandrino Fernandes; Artur M. S. Silva. "Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents". Pharmaceuticals 15 2 (2022): 148-148. http://dx.doi.org/10.3390/ph15020148.
    10.3390/ph15020148
  8. Carlos F. M. Silva; João A. Pacheco; Diana C. G. A. Pinto; Artur M. S. Silva. "A Valuable Method for the Synthesis of 2-Benzylchromones: A Comparative Evaluation of Both Conventional and Microwave-Assisted Synthesis". ChemistrySelect 7 2 (2022): https://doi.org/10.1002/slct.202103560.
    10.1002/slct.202103560
  9. Carlos Fábio Magalhães da Silva; Diana C. G. A. Pinto; Pedro Alexandrino Fernandes; Artur M. S. Silva. "Evolution of chromone-like compounds as potential antileishmanial agents, through the 21st century". Expert Opinion on Drug Discovery 15 12 (2020): 1425-1439. http://dx.doi.org/10.1080/17460441.2020.1801630.
    10.1080/17460441.2020.1801630
  10. Silva, Carlos F. M.; Pinto, Diana C. G. A.; Silva, Artur M. S.. "Chromones: privileged scaffolds for the production of multi-target-directed-ligand agents for the treatment of Alzheimer's disease". Expert Opinion on Drug Discovery 13 12 (2018): 1141-1151. http://dx.doi.org/10.1080/17460441.2018.1543267.
    10.1080/17460441.2018.1543267
  11. Silva, Carlos F. M.; Batista, Vasco F.; Pinto, Diana C. G. A.; Silva, Artur M. S.. "Challenges with chromone as a privileged scaffold in drug discovery". Expert Opinion on Drug Discovery 13 9 (2018): 795-798. http://dx.doi.org/10.1080/17460441.2018.1494720.
    Published • 10.1080/17460441.2018.1494720
  12. Silva, Carlos F. M.; Pinto, Diana C. G. A.; Silva, Artur M. S.. "Chromones: A Promising Ring System for New Anti-inflammatory Drugs". ChemMedChem 11 20 (2016): 2252-2260. http://dx.doi.org/10.1002/cmdc.201600359.
    Published • 10.1002/cmdc.201600359
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 Poster Presentation: Design, synthesis and evaluation of novel antileishmanial agents against Leishmania infantum European School of Medicinal Chemistry (ESMEC)
(Urbino, Italy)
2022 Poster Presentation: Design, synthesis and evaluation of novel antileishmanial agents against L. infantum promastigotes XXVII EFMC International Symposium on Medicinal Chemistry
(Nice, France)
2022 Oral Presentation: Structure-Activity Relationship (SAR) studies of 9-alkylamino-1,2,3,4-tetrahydroacridines against L. infantum promastigotes XIV National Meeting on Organic Chemistry and XII National Meeting on Therapeutic Chemistry
(Lisboa, Portugal)
2022 Oral Presentation: Design, synthesis and evaluation of novel potential antileishmanial agents. Research Summit
(Aveiro, Portugal)
2022 Oral Presentation: Design, synthesis and evaluation of novel antileishmanial agents. XXVI Encontro Galego-Portugués de Química
(Santiago de Compostela, Spain)
2021 Oral Presentation: Design, synthesis and evaluation of acridine derivatives as potential leishmanial inhibitors XXIX European Colloquium of Heterocyclic Chemistry, Virtual Event
(France)
2021 Oral Presentation: Design, synthesis and evaluation of novel potential antileishmanial agents. Research Summit
(Aveiro, Portugal)
2020 Poster Presentation: Chromones: A promising building block for medicinal chemistry. 13º National Meeting on Organic Chemistry and 6º National Meeting on Therapeutic Chemistry
(Aveiro, Portugal)
2020 Oral Presentation: Design, synthesis and evaluation of novel potential antileishmanial agents. Research Summit
(Aveiro, Portugal)
2019 Oral Presentation: Design, synthesis and evaluation of novel potential antileishmanial inhibitors Research Summi
(Aveiro, Portugal)
2019 Oral Presentation: Novel 9-substituted-acridine derivatives as potential Acetylcholinesterase inhibitors XXV Encontro Galego-Português de Química
(Santiago de Compostela, Spain)
2019 Poster Presentation: Microwave-assisted synthesis of 2-benzylchromones and further structural functionalization. XXVII Encontro Nacional da SPQ
(Porto, Portugal)
2017 Poster Presentation: 2-Benzylchromones: Synthesis of novel potential biologically active compounds XXV Encontro Nacional da SPQ
(Lisboa, Portugal)
2016 Oral Presentation: 2-Benzylchromones: Synthesis of a novel series of chromone derivatives as potential anti- inflammatory agents XXII Encontro Luso-Galego de Química
(Bragança, Portugal)
2015 Poster Presentation: Síntese e caracterização de novas 2-benzilcromonas 7th Biochemistry Day
University of Aveiro (Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/09 - Current Synthesis and biological evaluation of acridine-triazine hybrids as acetylcholinesterase and butyrylcholinesterase inhibitors
Co-supervisor
 Bioquímica (Master)
Universidade de Aveiro, Portugal
2022/10 - 2023/02 Synthesis and a-glucosidase inhibitory activity evaluation of quinic acid derivatives.
Co-supervisor
 Bioquímica (Other)
Universidade de Aveiro, Portugal
2022/03 - 2022/07 Synthesis of isoxazole derivatives.
Co-supervisor
 Química (Degree)
Universidade de Aveiro, Portugal
2022/03 - 2022/07 Synthesis of isoxazole derivatives.
Co-supervisor
 Química (Degree)
Universidade de Aveiro, Portugal
2020/02 - 2020/07 1,3,5-triazine: A promising molecular scaffold for novel agents for the treatment of Alzheimer’s Disease.
Co-supervisor
 Biotecnologia (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2019/02 - 2019/07 Synthesis and biological evaluation of new acridine-chromone hybrids.
Co-supervisor
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2018/02 - 2018/07 Síntese e estudos de oxidação de 2-benzilcromonas: Alternativa verde para obtenção de 2-estirilcromonas.
Co-supervisor
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016 - Current Preparation of the Portuguese delegation to the International Chemistry Olympiads (IChO) and Olimpíadas Ibero-Americanas de Química (OIAQ) (2016)
Other (Member of the Organising Committee)
 Sociedade Portuguesa de Química, Portugal
2016 - Current Semifinal and Final rounds of the Junior Chemistry Olympiads and Chemistry+ Olympiads (2016)
Other (Member of the Scientific Committee)
 Sociedade Portuguesa de Química, Portugal
2016 - Current Semifinal and Final rounds of the Junior Chemistry Olympiads and Chemistry+ Olympiads (2016)
Other (Member of the Organising Committee)
 Sociedade Portuguesa de Química, Portugal
2018/05 - 2019/12 PubhD Aveiro - Monthly presentation of PhD student for the academic and non-academic community. (2018/05 - 2019/12)
Other (Co-organisor)

Association member

Society Organization name Role
2015/01 - 2016/01 Nucleus of Chemistry Students of the Academic Association of the University of Aveiro Member of the Directory Board (Vogal of the Communication sector)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016 - Current Practical/Laboratory preparation classes for the portuguese delegation to the International Chemistry Olympiads (IChO) and Olimpíadas Ibero-Americanas de Química (OIAQ) (Ensino secundário)

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/08 - 2021/10 Student-Assessor of the External Evaluation Commission from Agência de Acreditação e Avaliação do Ensino Superior (A3ES). Evaluation of the Bachelor's degree on Biotechnology, Master's degree on Biotechnology and Doctoral degree on Biotechnological Sciences from the University of Algarve (Portugal).
Member
 Agência de Acreditação e Avaliação do Ensino Superior (A3ES), Portugal