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Margarida Ferreira-Silva is currently a postdoctoral researcher at BioNanoSciences - Drug Delivery & Immunoengineering lab at iMed.ULisboa, under the scope of the project “Multifunctional nano-immunotherapy against breast brain metastases” (LCF/PR/HR22/52420016), funded by “la Caixa” Foundation. In this project, she is developing polymeric nanoparticles as an immunotherapeutic strategy to prevent and treat metastatic brain cancers. Since 2015, Margarida has worked in research projects focused on the use of nanotechnology to develop novel therapeutics for cancer and inflammatory diseases. During her MSc, she explored lipid based-drug delivery nanosystems for the treatment of lung cancer. Afterwards, Margarida worked on the project LCO-2017-052/1-1, funded by the Phospholipid Research Center (Germany), focused on the development of liposomes with antioxidant and anti-inflammatory compounds to treat a hepatic inflammatory disease. In 2023, she concluded her PhD degree in Pharmacy (specialization in Pharmaceutical Technology), at Faculty of Pharmacy, University of Lisbon, Portugal. During her PhD, Margarida developed lipid and metallic nanoparticles to deliver drugs, natural compounds and biologic agents to the liver, improving the treatment of hepatic ischemia and reperfusion injury. Afterwards, she worked as a research fellow at CIISA, Faculty of Veterinary Medicine, University of Lisbon, Portugal, in a project funded by FCT (EXPL/CVT-CVT/1285/2021), where a trispecific antibody was developed for the anticancer immune targeting of non-Hodgkin Lymphoma. During that time, she also collaborated in a project funded by Gilead Sciences Europe (PGG/050/2019), that explored immunoliposomes to treat non-Hodgkin Lymphoma.
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Identification

Personal identification

Full name
Margarida Ferreira Silva
Date of birth
1993/11/21
Gender
Female

Citation names

  • Ferreira-Silva, Margarida
  • Silva, Margarida

Author identifiers

Ciência ID
3010-D7CA-D2B9
ORCID iD
0000-0002-5724-2823
Scopus Author Id
57211577334

Email addresses

  • msilva@farm-id.pt (Professional)

Addresses

  • Faculdade de Farmácia, Universidade de Lisboa. Avenida Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Engineering and Technology - Nano-technology
  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
Education
Degree Classification
2018/01/01 - 2023/05
Concluded
 Farmácia (Doutoramento)
Major in Tecnologia Farmacêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Targeting liver ischemia and reperfusion injury: nanoformulations for advanced drug/gene delivery" (THESIS/DISSERTATION)
 Summa cum laude
2021/10 - 2021/12
Concluded
 Interdisciplinary Training Program on Principles, Applications and Nanotechnology Innovation in Pharmaceutical Sciences, Biological Engineering and Medicine (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/10 - 2018/10
Concluded
 Postgraduate Course in Laboratory Animal Science (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 19/20
2014 - 2016
Concluded
 Master in Biochemistry, Specialization in Medical Biochemistry (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudo do direcionamento ativo de nanossistemas lipídicos com antagonista G para células de cancro de pulmão" (THESIS/DISSERTATION)
 19
2011 - 2014
Concluded
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"N/A" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2024/08 - Current Postdoc (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/02 - 2024/06 Researcher (Research) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/02/14 - 2022/07/15 Visiting Teacher (Polytechnic Teacher) Escola Superior de Saúde Egas Moniz, Portugal
Escola Superior de Saúde Egas Moniz, Portugal

Others

Category
Host institution 		Employer
2018/01/01 - 2023/05 PhD Research Grant Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2018/01/01 - 2023/05 PhD Research Grant REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2018/01/01 - 2023/05 PhD Research Grant Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2017/10/11 - 2018/01/01 Master’s Research Grant in the project “Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury" Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/05/01 - 2016/07/01 Technician on the project "Formulação da asparaginase II de Saccharomyces cerevisiae clonada e expressa em Pichia pastoris visando o desenvolvimento de biofármaco antileucêmico" Joint Project Fundaçã Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/09/01 - 2016/07/01 Internship in the scope of master thesis "Estudo do direcionamento ativo de nanossistemas lipídicos com antagonista G para células de cancro de pulmão". Universidade de Lisboa Faculdade de Ciências, Portugal
2014/10 - 2015/04 Volunteer internship in cell culture techniques and aseptic work Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Projects

Grant

Designation Funders
2024/08 - Current Multifunctional nano-immunotherapy against breast brain metastases
LCF/PR/HR22/52420016
Post-doc Fellow
“La Caixa” Banking Foundation, Spain
 “La Caixa” Banking Foundation
Ongoing
2023/03 - 2024/06 TRIFECTA - Development of a novel trispecific antibody for the anticancer immune targeting of non-Hodgkin Lymphoma
EXPL/CVT-CVT/1285/2021
Researcher
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/01/01 - 2022/01/01 Targeting liver ischemia reperfusion injury: nanoformulations for gene silencing
PD/BD/135264/2017
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2017/10 - 2018/01 Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury
200009
Master Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universitätsklinikum Aachen, Germany
Phospholipid Forschungszentrum e V
Concluded

Contract

Designation Funders
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade do Porto, Portugal

Universidade Nova de Lisboa, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Instituto de Investigação do Medicamento
UID/DTP/04138/2019
154706UID
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
154717UID
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Ana I. Matos; Carreira, Barbara; Acúrcio, Rita C; Ferreira-Silva, Margarida; Ferro, Cláudio; Graca, Luis; Satchi-Fainaro, Ronit; Helena F Florindo. "Multidirectional Nano-Immunotherapy against Breast Brain Metastases". Paper presented in 5th SPLC-CRS Young Scientists Meeting: Small Pieces for Big Breakthroughs, 2025.
  2. Leonardo, Ana Sofia; Andre, Ana; Ferreira-Silva, Margarida; Aguiar, Sandra I; Nogueira, Sara; Cavaco, Marco; Gano, Lurdes; et al. "Tackling non-Hodgkin lymphoma on two fronts: Dual-targeting immunoliposomes as a novel drug delivery system". Paper presented in Congress of Microbiology and Biotechnology 2023, 2023.
  3. Ferreira-Silva, Margarida; Rosa, Inês; Basto, Afonso P.; Bule, Pedro; Nogueira, Sara; Storb, Rainer; Tavares, Luis; Frederico Aires da Silva; Dias, Joana N. R.. "Development of a novel T-cell engager trispecific antibody for enhanced immune targeting of non-Hodgkin Lymphoma". Paper presented in Congress of Microbiology and Biotechnology 2023, 2023.
  4. Ferreira-Silva, Margarida; Rosa, Inês; Basto, Afonso P.; Bule, Pedro; Nogueira, Sara; Storb, Rainer; Tavares, Luis; Frederico Aires da Silva; Dias, Joana N. R.. "Development of a novel trispecific antibody for the anticancer immune targeting of non-Hodgkin lymphoma". Paper presented in 15th Annual PEGS Europe - Protein and Antibody Engineering Summit 2023, 2023.
  5. Leonardo, Ana Sofia; S. André, Ana; Ferreira-Silva, Margarida; Aguiar, Sandra I; Nogueira, Sara; Cavaco, Marco; Gano, Lurdes; et al. Corresponding author: Dias, Joana N. R.. "Dual-targeting immunoliposomes as a promising therapeutic strategy for non-Hodgkin Lymphoma". Paper presented in Antibody Engineering and Therapeutics Europe, 2023.
  6. Ferreira-Silva, Margarida; Faria-Silva, C.; Carvalheiro, Manuela; Simões, Sandra; Fernandes, Eduarda (EF18-DEF3-9E2F); Baptista, Pedro; Alexandra R Fernandes; Corvo, M. Luisa. "Quercetin liposomes for hepatic ischemia and reperfusion injury a promising therapeutic approach". Paper presented in First Symposium on Advanced Technologies on Drug Delivery, 2021.
  7. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Metselaar, Josbert; Corvo, M. Luisa; Fernandes, Alexandra. "Evaluation of anti-inflammatory effect of quercetin liposomes in hepatic ischemia and reperfusion injury". Paper presented in XIIIth Spanish Portuguese Conference on Controlled Drug Delivery, 2020.
  8. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Fernandes, Eduarda (EF18-DEF3-9E2F); Fernandes, Alexandra; Corvo, M. Luisa. "Evaluation of anti-inflammatory efficacy of liposomal formulations developed for hepatic ischemia and reperfusion injury’s treatment". Paper presented in 6th International Symposium on Phospholipids in Pharmaceutical Research, 2019.
  9. Ferreira-Silva, Margarida; Faria-Silva, Ana Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Josbert Maarten Metselaar; Corvo, M. Luisa; Fernandes, Alexandra. "Assessment Of Anti inflammatory Efficacy Of Liposomal Formulations Developed For The Treatment Of Hepatic Ischemia And Reperfusion Injury". Paper presented in 2019 Controlled Release Society Annual Meeting Exposition, 2019.
  10. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Fernandes, Eduarda (EF18-DEF3-9E2F); Fernandes, Alexandra; Corvo, M. Luisa. "Development of Quercetin Liposomal Formulations for Hepatic Ischemia Reperfusion Injury Prevention". Paper presented in 11th iMed ULisboa Postgraduate Students Meeting & 4th i3DU Meeting, 2019.
  11. Faria-Silva, Catarina; Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Simões, Sandra; Fernandes, Alexandra R.; Corvo, M. Luísa. "Development of Indomethacin Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury Prevention.". Paper presented in 2019 Controlled Release Society Annual Meeting & Exposition., 2019.
  12. Ferreira-Silva, Margarida; Faria-Silva, Ana Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro V. (CD1B-47A3-AB05); Fernandes, Eduarda (EF18-DEF3-9E2F); Fernandes, Alexandra; Corvo, M. Luisa. "Development of Anti-Inflammatory Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting, 2018.
  13. Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Holovanchuk, Denys; Soares, Helena; H. Susana Marinho; Corvo, M. Luisa. "Antagonist G-labeled long circulating liposomes actively targeted to lung tumor cells". Paper presented in 5th International Symposium on Phospholipids in Pharmaceutical Research;, 2017.
  14. Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Holovanchuk, Denys; Soares, Helena; Marinho, H. Susana (D315-F250-6AF2); Corvo, M. Luisa. "Active targeting of lung tumor cells using antagonist G labeled long circulating liposomes". Paper presented in 8th iMed.ULisboa Postgraduate Students Meeting & 1st i3DU Meeting, 2016.
Journal article
  1. Cláudia Braga; Margarida Ferreira-Silva; M. Luísa Corvo; Rui Moreira; Alexandra R. Fernandes; João Vaz; Maria J. Perry. "Nitroaromatic-based triazene prodrugs to target the hypoxic microenvironment in glioblastoma". RSC Medicinal Chemistry (2025): https://doi.org/10.1039/D4MD00876F.
    10.1039/D4MD00876F
  2. Margarida Ferreira-Silva; Ana Catarina Faria da Silva Severiano; Manuela Carvalheiro; Sandra Simões; H. Susana Marinho; Paulo Marcelino; Maria Celeste Campos; et al. "Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/1/104.
    10.3390/pharmaceutics14010104
  3. Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; Marinho, H. Susana; Moreira, João Nuno; Soares, Helena; Corvo, M. Luisa; Cruz, Maria Eugénia M.. "Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma". International Journal of Pharmaceutics 612 (2022): 121380. http://dx.doi.org/10.1016/j.ijpharm.2021.121380.
    Published • 10.1016/j.ijpharm.2021.121380
  4. Lenis-Rojas, Oscar A.; Carvalho, Beatriz; Cabral, Rui; Ferreira-Silva, Margarida; Friães, Sofia; Roma-Rodrigues, Catarina; Meireles, Marta S. H.; et al. Corresponding author: Fernandes, Alexandra. "Manganese(I) tricarbonyl complexes as potential anticancer agents". JBIC Journal of Biological Inorganic Chemistry (2021): http://dx.doi.org/10.1007/s00775-021-01910-7.
    10.1007/s00775-021-01910-7
  5. Luciana F. C. Girão; Manuela Colla Carvalheiro; Margarida Ferreira-Silva; Surza L. G. da Rocha; Jonas Perales; M. Bárbara F. Martins; Maria Antonieta Ferrara; Elba P. S. Bon; M. Luísa Corvo. "ASP-Enzymosomes with Saccharomyces cerevisiae Asparaginase II Expressed in Pichia pastoris: Formulation Design and In Vitro Studies of a Potential Antileukemic Drug". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222011120.
    10.3390/ijms222011120
  6. Margarida Ferreira-Silva; Catarina Faria-Silva; Pedro Viana Baptista; Eduarda Fernandes; Alexandra Ramos Fernandes; Maria Luísa Corvo. "Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury". Drug Delivery and Translational Research 11 2 (2021): 397-410. https://doi.org/10.1007/s13346-021-00915-8.
    10.1007/s13346-021-00915-8
  7. Margarida Ferreira-Silva; Catarina Faria-Silva; P. V. Baptista; Eduarda Fernandes; Alexandra Fernandes; Maria Luísa Corvo. "Liposomal Nanosystems in Rheumatoid Arthritis". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/4/454.
    10.3390/pharmaceutics13040454
  8. Pedro Pedrosa; M. Luísa Corvo; Margarida Ferreira-Silva; Pedro Martins; Manuela Colla Carvalheiro; Pedro M. Costa; Carla Martins; et al. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles". International Journal of Molecular Sciences 20 21 (2019): 5510-5510. https://doi.org/10.3390/ijms20215510.
    10.3390/ijms20215510
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/16 Development of a novel trispecific antibody for the anticancer immune targeting of non-Hodgkin lymphoma 15th Annual PEGS Europe - Protein and Antibody Engineering Summit 2023
PEGS Europe (Lisbon, Portugal)
2023/10/21 Unveiling the potential of T cell engager antibodies: development of a novel trispecific antibody for the antitumoral immune targeting of non-Hodgkin lymphoma AL4AnimalS - Comparative Translational Medicine and Biotechnology
AL4AnimalS (Porto, Portugal)
2022/07/04 Quercetin Liposomes – an Anti-Inflammatory Therapeutic Approach for Hepatic Ischemia and Reperfusion Injury 13th iMed.ULisboa Students Meeting
Faculty of Pharmacy, University of Lisbon (Lisbon, Portugal)
2022/04/21 Quercetin liposomes: an effective anti-inflammatory treatment for hepatic ischemia and reperfusion injury demonstrated in vitro and in vivo 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting
Sociedado Portuguesa de Química (Almada, Portugal)
2020/01/22 Evaluation of anti-inflammatory effect of quercetin liposomes in hepatic ischemia and reperfusion injury XIIIth Spanish Portuguese Conference on Controlled Drug Delivery
Controlled Release Society - Spanish Portuguese Local Chapter (Santiago de Compostela, Spain)
2018/06/26 In vitro efficacy of liposomal antioxidant and anti inflammatory formulations developed for liver ischemic reperfusion injury’s treatment Researcher’s Day 2018
Phospholipid Research Center (Limburgerhof, Germany)
2017/09/19 Antagonist G labeled long circulating liposomes actively targeted to lung tumor cells 5th International Symposium on Phospholipids in Pharmaceutical Research
Phospholipid Research Center (Heidelberg, Germany)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/14 - 2022/07/15 Biotecnologia Microbiologia e Biologia Molecular (Curso Técnico Superior Profissional) Escola Superior de Saúde Egas Moniz, Portugal
2022/02/14 - 2022/07/15 Técnicas de Biologia Molecular Microbiologia e Biologia Molecular (Curso Técnico Superior Profissional) Escola Superior de Saúde Egas Moniz, Portugal
Distinctions

Other distinction

2017 Poster Award
Phospholipid Research Center, Germany
2015 Diploma de Mérito Académico no 1º ano do Mestrado em Bioquímica
Universidade de Lisboa Faculdade de Ciências, Portugal