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Margarida Ferreira-Silva is a PhD student at Faculdade de Farmácia, Universidade de Lisboa and is enrolled in the PhD Programme in Medicines and Pharmaceutical Innovation (i3DU). She holds a Master’s Degree in Biochemistry (2016, Faculdade de Ciências, Universidade de Lisboa) and currently works in three groups: iMed.ULisboa (Lisbon, Portugal), UCIBIO/REQUIMTE (Lisbon, Portugal) and LAQV/REQUIMTE (Porto, Portugal). Her PhD in Pharmaceutical Technology is focused on developing drug delivery systems for treatment of hepatic ischemia and reperfusion injury.
Identification

Personal identification

Full name
Margarida Ferreira Silva
Date of birth
1993/11/21
Gender
Female

Citation names

  • Ferreira-Silva, Margarida
  • Silva, Margarida

Author identifiers

Ciência ID
3010-D7CA-D2B9
ORCID iD
0000-0002-5724-2823
Scopus Author Id
57211577334

Email addresses

  • msilva@farm-id.pt (Professional)

Addresses

  • Faculdade de Farmácia, Universidade de Lisboa. Avenida Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
Education
Degree Classification
2018/01/01 - 2023/05
Concluded
 Farmácia (Doutoramento)
Major in Tecnologia Farmacêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Targeting liver ischemia and reperfusion injury: nanoformulations for advanced drug/gene delivery" (THESIS/DISSERTATION)
2014 - 2016
Concluded
 Master in Biochemistry, Specialization in Medical Biochemistry (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudo do direcionamento ativo de nanossistemas lipídicos com antagonista G para células de cancro de pulmão" (THESIS/DISSERTATION)
 19
2011 - 2014
Concluded
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"N/A" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2024/08 - Current Postdoc (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/02 - 2024/06 Researcher (Research) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/02/14 - 2022/07/15 Visiting Teacher (Polytechnic Teacher) Escola Superior de Saúde Egas Moniz, Portugal
Escola Superior de Saúde Egas Moniz, Portugal

Others

Category
Host institution 		Employer
2018/01/01 - 2023/05 PhD Research Grant Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2018/01/01 - 2023/05 PhD Research Grant REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2018/01/01 - 2023/05 PhD Research Grant Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2017/10/11 - 2018/01/01 Master’s Research Grant in the project “Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury" Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/05/01 - 2016/07/01 Technician on the project "Formulação da asparaginase II de Saccharomyces cerevisiae clonada e expressa em Pichia pastoris visando o desenvolvimento de biofármaco antileucêmico" Joint Project Fundaçã Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/09/01 - 2016/07/01 Internship in the scope of master thesis "Estudo do direcionamento ativo de nanossistemas lipídicos com antagonista G para células de cancro de pulmão". Universidade de Lisboa Faculdade de Ciências, Portugal
2014/10 - 2015/04 Volunteer internship in cell culture techniques and aseptic work Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Projects

Grant

Designation Funders
2024/08 - Current Multifunctional nano-immunotherapy against breast brain metastases
LCF/PR/HR22/52420016
Post-doc Fellow
“La Caixa” Banking Foundation, Spain
 “La Caixa” Banking Foundation
Ongoing
2023/03 - Current TRIFECTA - Development of a novel trispecific antibody for the anticancer immune targeting of non-Hodgkin Lymphoma
EXPL/CVT-CVT/1285/2021
Researcher
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/01/01 - 2022/01/01 Targeting liver ischemia reperfusion injury: nanoformulations for gene silencing
PD/BD/135264/2017
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2017/10 - 2018/01 Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury
200009
Master Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universitätsklinikum Aachen, Germany
Phospholipid Forschungszentrum e V
Ongoing
Outputs

Publications

Conference poster
  1. Ferreira-Silva, Margarida; Faria-Silva, C.; Carvalheiro, Manuela; Simões, Sandra; Fernandes, Eduarda (EF18-DEF3-9E2F); Baptista, Pedro; Alexandra R Fernandes; Corvo, M. Luisa. "Quercetin liposomes for hepatic ischemia and reperfusion injury a promising therapeutic approach". Paper presented in First Symposium on Advanced Technologies on Drug Delivery, 2021.
  2. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Metselaar, Josbert; Corvo, M. Luisa; Fernandes, Alexandra. "Evaluation of anti-inflammatory effect of quercetin liposomes in hepatic ischemia and reperfusion injury". Paper presented in XIIIth Spanish Portuguese Conference on Controlled Drug Delivery, 2020.
  3. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Fernandes, Eduarda (EF18-DEF3-9E2F); Fernandes, Alexandra; Corvo, M. Luisa. "Evaluation of anti-inflammatory efficacy of liposomal formulations developed for hepatic ischemia and reperfusion injury’s treatment". Paper presented in 6th International Symposium on Phospholipids in Pharmaceutical Research, 2019.
  4. Ferreira-Silva, Margarida; Faria-Silva, Ana Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Josbert Maarten Metselaar; Corvo, M. Luisa; Fernandes, Alexandra. "Assessment Of Anti inflammatory Efficacy Of Liposomal Formulations Developed For The Treatment Of Hepatic Ischemia And Reperfusion Injury". Paper presented in 2019 Controlled Release Society Annual Meeting Exposition, 2019.
  5. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Fernandes, Eduarda (EF18-DEF3-9E2F); Fernandes, Alexandra; Corvo, M. Luisa. "Development of Quercetin Liposomal Formulations for Hepatic Ischemia Reperfusion Injury Prevention". Paper presented in 11th iMed ULisboa Postgraduate Students Meeting & 4th i3DU Meeting, 2019.
  6. Faria-Silva, Catarina; Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Simões, Sandra; Fernandes, Alexandra R.; Corvo, M. Luísa. "Development of Indomethacin Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury Prevention.". Paper presented in 2019 Controlled Release Society Annual Meeting & Exposition., 2019.
  7. Ferreira-Silva, Margarida; Faria-Silva, Ana Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro V. (CD1B-47A3-AB05); Fernandes, Eduarda (EF18-DEF3-9E2F); Fernandes, Alexandra; Corvo, M. Luisa. "Development of Anti-Inflammatory Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting, 2018.
  8. Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Holovanchuk, Denys; Soares, Helena; H. Susana Marinho; Corvo, M. Luisa. "Antagonist G-labeled long circulating liposomes actively targeted to lung tumor cells". Paper presented in 5th International Symposium on Phospholipids in Pharmaceutical Research;, 2017.
  9. Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Holovanchuk, Denys; Soares, Helena; Marinho, H. Susana (D315-F250-6AF2); Corvo, M. Luisa. "Active targeting of lung tumor cells using antagonist G labeled long circulating liposomes". Paper presented in 8th iMed.ULisboa Postgraduate Students Meeting & 1st i3DU Meeting, 2016.
Journal article
  1. Margarida Ferreira-Silva; Ana Catarina Faria da Silva Severiano; Manuela Carvalheiro; Sandra Simões; H. Susana Marinho; Paulo Marcelino; Maria Celeste Campos; et al. "Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/1/104.
    10.3390/pharmaceutics14010104
  2. Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; Marinho, H. Susana; Moreira, João Nuno; Soares, Helena; Corvo, M. Luisa; Cruz, Maria Eugénia M.. "Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma". International Journal of Pharmaceutics 612 (2022): 121380. http://dx.doi.org/10.1016/j.ijpharm.2021.121380.
    Published • 10.1016/j.ijpharm.2021.121380
  3. "Manganese(I) tricarbonyl complexes as potential anticancer agents". JBIC Journal of Biological Inorganic Chemistry (2021): http://dx.doi.org/10.1007/s00775-021-01910-7.
    10.1007/s00775-021-01910-7
  4. Luciana F. C. Girão; Manuela Colla Carvalheiro; Margarida Ferreira-Silva; Surza L. G. da Rocha; Jonas Perales; M. Bárbara F. Martins; Maria Antonieta Ferrara; Elba P. S. Bon; M. Luísa Corvo. "ASP-Enzymosomes with Saccharomyces cerevisiae Asparaginase II Expressed in Pichia pastoris: Formulation Design and In Vitro Studies of a Potential Antileukemic Drug". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222011120.
    10.3390/ijms222011120
  5. Margarida Ferreira-Silva; Catarina Faria-Silva; Pedro Viana Baptista; Eduarda Fernandes; Alexandra Ramos Fernandes; Maria Luísa Corvo. "Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury". Drug Delivery and Translational Research 11 2 (2021): 397-410. https://doi.org/10.1007/s13346-021-00915-8.
    10.1007/s13346-021-00915-8
  6. Margarida Ferreira-Silva; Catarina Faria-Silva; P. V. Baptista; Eduarda Fernandes; Alexandra Fernandes; Maria Luísa Corvo. "Liposomal Nanosystems in Rheumatoid Arthritis". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/4/454.
    10.3390/pharmaceutics13040454
  7. Pedro Pedrosa; M. Luísa Corvo; Margarida Ferreira-Silva; Pedro Martins; Manuela Colla Carvalheiro; Pedro M. Costa; Carla Martins; et al. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles". International Journal of Molecular Sciences 20 21 (2019): 5510-5510. https://doi.org/10.3390/ijms20215510.
    10.3390/ijms20215510
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/07/04 Quercetin Liposomes – an Anti-Inflammatory Therapeutic Approach for Hepatic Ischemia and Reperfusion Injury 13th iMed.ULisboa Students Meeting
Faculty of Pharmacy, University of Lisbon (Lisbon, Portugal)
2022/04/21 Quercetin liposomes: an effective anti-inflammatory treatment for hepatic ischemia and reperfusion injury demonstrated in vitro and in vivo 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting
Sociedado Portuguesa de Química (Almada, Portugal)
2020/01/22 Evaluation of anti-inflammatory effect of quercetin liposomes in hepatic ischemia and reperfusion injury XIIIth Spanish Portuguese Conference on Controlled Drug Delivery
Controlled Release Society - Spanish Portuguese Local Chapter (Santiago de Compostela, Spain)
2018/06/26 In vitro efficacy of liposomal antioxidant and anti inflammatory formulations developed for liver ischemic reperfusion injury’s treatment Researcher’s Day 2018
Phospholipid Research Center (Limburgerhof, Germany)
2017/09/19 Antagonist G labeled long circulating liposomes actively targeted to lung tumor cells 5th International Symposium on Phospholipids in Pharmaceutical Research
Phospholipid Research Center (Heidelberg, Germany)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/14 - 2022/07/15 Biotecnologia Microbiologia e Biologia Molecular (Curso Técnico Superior Profissional) Escola Superior de Saúde Egas Moniz, Portugal
2022/02/14 - 2022/07/15 Técnicas de Biologia Molecular Microbiologia e Biologia Molecular (Curso Técnico Superior Profissional) Escola Superior de Saúde Egas Moniz, Portugal
Distinctions

Other distinction

2017 Poster Award
Phospholipid Research Center, Germany
2015 Diploma de Mérito Académico no 1º ano do Mestrado em Bioquímica
Universidade de Lisboa Faculdade de Ciências, Portugal