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Fernanda Maria Fernandes Roleira has a PhD in Pharmaceutical Chemistry from the Faculty of Pharmacy of the University of Porto and is currently a Professor and Researcher at the Laboratory of Pharmaceutical Chemistry of the Faculty of Pharmacy of the University of Coimbra. She is also Coordinator of the Paul Ehrlich MedChem Euro-PhD Network for the University of Coimbra. Her research interests focus on the area of Medicinal Chemistry and her entire career was related to the discovery of new molecules with biological activity, namely steroidal aromatase inhibitors, with interest in the treatment of estrogen-dependent breast cancer and phenolic cinnamic acid derivatives, with interest as antioxidants, anticancer and anti-inflammatories. In this context, she submitted a national and an international patent, published 4 book chapters, 60 articles in scientific journals with reviewers (3 of which in the Journal of Medicinal Chemistry), with 2592 citations (WoS) and 2903 citations (Scopus), 26 abstracts in scientific journals with reviewers and 5 proceedings. She also delivered 46 oral communications as an author or co-author and presented 112 poster communications. She was a reviewer of several scientific articles (8 of which in the Journal of Medicinal Chemistry), supervised 4 PhD students and several master students. She also supervised several international SEP and Erasmus students. She participated in 4 scientific projects, 9 national and international PhD juries, and 12 Master's juries.
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Identification

Personal identification

Full name
Fernanda Maria Fernandes Roleira

Citation names

  • Roleira, Fernanda

Author identifiers

Ciência ID
3014-1554-7001
ORCID iD
0000-0003-4229-5882

Email addresses

  • froleira@ff.uc.pt (Professional)

Telephones

Fax
  • 239827126 (Professional)
Telephone
  • 239488400 (Professional)

Addresses

  • Faculty of Pharmacy, University of Coimbra. Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 , Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
1996
Concluded
 Pharmaceutical Chemistry (Doutoramento)
Major in Sem especialidade
Universidade do Porto Faculdade de Farmácia, Portugal
"Planeamento e Síntese de Fendas Moleculares - Complexos de Associação com Antivirais por Reconhecimento Molecular Artificial" (THESIS/DISSERTATION)
1991
Concluded
 Pharmaceutical sciences (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
 Dezasseis (16) valores
1985
Concluded
 Ensino secundário (Ensino secundário)
Escola Secundária de Monção, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2001/04/08 - Current Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
1996/07/26 - 2001/04/07 Assistant (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
1996/04/08 - 1996/07/25 Trainee Assistant (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
1991/10/01 - 1995/09/30 PhD Scholarship Universidade do Porto Faculdade de Farmácia, Portugal
1989/10/01 - 1991/09/30 Research Initiation Scholarship Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2012/03 - 2015/02 New enzyme inhibitors for breast and prostate cancers: insights to overcome bone loss and endocrine resistance
Provided by PTCRIS: 120319
 Fundação para a Ciência e a Tecnologia
2010/04 - 2013/03 Opening Pandora's Box for Active Anti-Breast Cancer Therapy - The Role of Selective Targeting to Mitochondria
Provided by PTCRIS: 101409
 Fundação para a Ciência e a Tecnologia
2007/01 - 2009/06 Development of New Anticancer Agents: Phenolic Derivatives of Natural or Synthetic Origin - Structure-Activity Relationships
Provided by PTCRIS: 82117
 Fundação para a Ciência e a Tecnologia
2005/10 - 2007/04 Development of New Anticancer Agents: Phenolic Derivatives of Natural or Synthetic Origin - Structure-Activity Relationships
Provided by PTCRIS: 55631
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2019/01/01 - 2019/12/31 Centro de Investigação em Engenharia dos Processos Químicos e dos Produtos da Floresta
UID/EQU/00102/2019
Universidade de Coimbra Centro de Investigação em Engenharia dos Processos Químicos e dos Produtos da Floresta, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 177 - 2011-2012
PEst-OE/SAU/UI0177/2011
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 36 - 2011-2012
PEst-C/FIS/UI0036/2011
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Roleira, Fernanda. "The health components of spices and herbs: The medicinal chemistry point of view". In Aromatic Herbs in Foods, 35-92. Elsevier, 2021.
    Published
  2. Roleira, Fernanda. "Phenolic Derivatives From Medicinal Herbs and Plant Extracts: Anticancer Effects and Synthetic Approaches to Modulate Biological Activity". 2018.
    10.1016/b978-0-444-64057-4.00004-1
  3. Roleira, Fernanda. "Antioxidants and Stroke: Success and Pitfalls". 2012.
    10.1007/978-1-4419-9530-8_6
  4. Borges, M.F.M.; Roleira, F.M.F.; Milhazes, N.J.S.P.; Villares, E.U.; Penin, L.S.. "Simple coumarins: Privileged scaffolds in medicinal chemistry". 2009.
Conference abstract
  1. Laranjo, M.; Gomes, A.R.; Costa, S.; Abrantes, A.M.; Gonçalves, A.C.; Alves, R.; Botelho, M.F.; et al. "80P Steroidal oximes: A new potential therapeutic approach for cancer treatment". 2023.
    10.1016/j.annonc.2023.09.1580
  2. Gomes, A. R.; Pires AS; Abrantes, Ana Margarida; Varela, C.; Tavares-Silva, E.; Botelho, Maria Filomena; Roleira, Fernanda. "Synthesis and antitumor evaluation of new steroidal oximes in several cancer cell lines". Paper presented in CIMAGO Seminar ¿ Challenges in Oncology, Coimbra, 2020.
    Published
  3. Amaral, C.; Augusto, T.; Roleira, F.; Tavares-Da-Silva, E.; Correia-Da-Silva, G.; Teixeira, N.. "Estrogen-dependent breast cancer: The importance of androgen receptor in exemestane treatment". 2017.
  4. Amaral, C.; Augusto, T.; Tavares-da-Silva, E.; Roleira, F.M.F.; Correia-da-Siva, G.; Teixeira, N.. "Unveiling the mechanisms of exemestane-acquired resistance: The role of autophagy and PI3K pathway". 2016.
    10.1016/s0959-8049(16)61502-2
  5. Amaral, Cristina; Correia-da-Siva, Georgina; Roleira, Fernanda M. F.; Tavares da Silva, Elisiário; Teixeira, Natercia. "Estrogen-Dependent breast cancer: Autophagy as a potential mechanism of exemestane-acquired resistance". 2016.
  6. Fernanda M. F. Roleira; C. Tomé; T. Bernardo; T. Serafim; P. Oliveira; Varela, C.; Borges, F.; R. Carvalho; Tavares-da-Silva, E.. "Design, Synthesis and Antiproliferative Activities of Cinnamic and Hydrocinnamic Acid Lipophilic Derivatives". Paper presented in 4th BBBB - Bled International Conference on Pharmaceutical Sciences - Eur. J. Pharm. Sci., 2011.
  7. Varela, Carla L.; Fernanda Roleira; Margarida M. D. S. Cepa; Margarida Azevedo; Cristina B. Amaral; Georgina Correia-da-Silva; Natércia A. A. Teixeira; Elisiário Tavares da Silva. "Design Synthesis and Biological Evaluation Towards Aromatase of C-4 Derivatives of Formestane and 5alpha-Androst-3-en-17-one”". Paper presented in XXI International Symposium on Medicinal Chemistry - Drugs of the Future, 2010.
  8. Varela, Carla L.; Elisiário Tavares da Silva; Margarida M. D. S. Cepa; Margarida Azevedo; Cristina B. Amaral; Correia-da-Silva, Georgina; Natércia A. A. Teixeira; Fernanda M. F. Roleira. "Structure-Activity Relationships on D-Ring Modified 3-Deoxy-3-Androstenes as Aromatase inhibitors". Paper presented in XXI International Symposium on Medicinal Chemistry - Drugs of the Future, 2010.
  9. Roleira, Fernanda; Sintra, Tania; Varela, Carla; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natercia; Tavares-da-Silva, Elisiario. "THE EFFECT OF C-3 STEREOCHEMISTRY IN THE AROMATASE INHIBITORY ACTIVITY OF 3-HYDROXY-4-ANDROSTENES. A STRUCTURE-ACTIVITY STUDY". 2009.
  10. Varela, Carla; Roleira, Fernanda; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natercia; Tavares-da-Silva, Elisiario. "ANDROSTENES vs EPOXYANDROSTANES. THE ROLE OF THE PLANARITY OF THE A-RING IN AROMATASE INHIBITION. A STRUCTURE-ACTIVITY STUDY". 2009.
  11. Teresa L. Serafim; Carvalho, Filipa S.; Marques, Maria P.; Garrido, Jorge; Milhazes, Nuno; Borges, Fernanda; Fernanda M. F. Roleira; et al. "Biochemical Activity of Phenolic Derivatives on Tumour Cell Proliferation and Isolated Mitochondria". Paper presented in XX International Symposium on Medicinal Chemistry - Drugs of the Future, Viena, 2008.
  12. Elisiário J. Tavares da Silva; Margarida M. D. S. Cepa; Correia-da-Silva, Georgina; Natércia A. A. Teixeira; Varela, Carla L.; Fernanda Roleira. "Structure-Activity Relationships on 4-Androstenes and 5¿-Androstan-4-ones as Aromatase Inhibitors". Paper presented in XX International Symposium on Medicinal Chemistry - Drugs of the Future, 2008.
  13. Cepa, M.; Pedrosa F.; Correia-Da-Silva, G.; Elisiário J. Tavares da Silva; Fernanda M. F. Roleira; Phung S.; Chen, S.; Teixeira, N.A.. "Screening of New Aromatase Inhibitors in Aromatase Expressing Cell Lines: Potential Use in Breast Cancer Therapy". Paper presented in 4th International Symposium on Target Anticancer Therapies (TAT 2006) - Annals of Oncology, 2006.
  14. Cepa, M.; Correia-Da-Silva, G.; Tavares Da Silva, E.; Fernanda M. F. Roleira; Teixeira, N.. "Evaluation of the Biochemical Activity of new Modified Steroids as Aromatase Inhibitors". Paper presented in 29th FEBS Congres - FEBS Journal, Varsóvia, 2004.
    Published
  15. Elisiário J. Tavares da Silva; Fernanda M. Fernandes Roleira. "Design and Synthesis of New Cyano Derivatives of Formestane and D-Lactone Formestane as Potencial Aromatase Inhibitors". Paper presented in XVIIth International Symposium on Medicinal Chemistry - Drugs of the Future, Barcelona, 2002.
    Published
Conference paper
  1. Roleira, Fernanda. "DEVELOPMENT AND CHARACTERIZATION OF A NOVEL MIXED POLYMERIC MICELLE AS A POTENTIAL THERAPEUTIC STRATEGY FOR OSTEOSARCOMA". Paper presented in The 1st International Electronic Conference on Pharmaceutics, 2020.
    Published
  2. Domingues, Cátia; Jarak, Ivana; Varela, Carla; Tavares, Elisiário; Roleira, Fernanda; Alvarez-Lorenzo, Carmen; Concheiro, Angel; et al. "Synthesis and Characterization of a Novel Nanomicellar System Pluronic-PEI Suitable for Gene and Drug Co-Delivery in Cancer Therapy". 2020.
    10.3390/iecp2020-08795
  3. Roleira, Fernanda. "A NEW APPROACH FOR OSTEOSARCOMA THERAPY: PREPARATION AND CHARACTERIZATION OF MICELLEPLEXES OF PLURONIC L64-PEI-MIR-145". Paper presented in 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, 2018.
    Published
  4. Sobral, Ana Filipa; Faculdade de Ciências e Tecnologia, Universidade de Coimbra; UCIBIO, REQUIMTE, Laboratório de Bioquí; Amaral, Cristina; UCIBIO, REQUIMTE, Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmáci; Varela, Carla; CNC, IBILI, Grupo de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra; Tavares, Elisiário; CNC, IBILI, Grupo de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra; Roleira, Fernanda; CNC, IBILI, Grupo de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra; Correia-Da-Silva, Georgina; UCIBIO, REQUIMTE, Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade ; Teixeira, Natércia; UCIBIO, REQUIMTE, Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmá; et al. "New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models". Paper presented in IV Encontro Nacional Pós - Graduação em Ciências Biológicas CAPTAR - Ciência e ambiente para todos, Aveiro, 2016.
    https://doi.org/10.34624/captar.v6i1.13117
  5. Roleira, Fernanda. "APPROACHES TO HYBRIDS OF ESTRA-1,3,5(10)-TRIENES AND OF ESTRA-1,3,5(10),6-TETRAENES WITH BIOLOGICALLY ACTIVE MOLECULES". Paper presented in 3rd Cross Straits Symposium on Materials, Energy and Environmental Engineering, 2001.
    Published
Conference poster
  1. Janela, João Sousa; Lucas, Mariana; Freitas, Marisa; Shriki, Dania; Varela, Carla; Tavares da Silva, Elisiário; Fernandes, Eduarda; Roleira, Fernanda. "Design, synthesis and structure-activity relationships of amides derived from 3,5-di-tert-butyl-4-hydroxycinnamic acid as COX-2 inhibitors". Paper presented in XII Paul Ehrlich MedChem EuroPhD Network Symposium (MedChem 2023), 2023.
  2. Pires, Lucas de O. ; Janela, João; Lucas, Mariana; Freitas, Marisa; Castro, Rosane N. ; Fernandes, Eduarda; Roleira, Fernanda; Tavares da Silva, Elisiário. "Design, Synthesis and Study of the Structure-Activity Relationships of New O-Prenylated Amides from Caffeic Acid as COX-2 Inhibitors". Paper presented in XII Paul Ehrlich MedChem EuroPhD Network Symposium (MedChem 2023), 2023.
  3. Lucas, Mariana; Ribeiro, Daniela; Shriki, Dania; Janela, João; Varela, Carla; Tavares-da-Silva, Elisiário; Fernandes, Eduarda; Roleira, Fernanda. "Ligand-base design, synthesis and structure-activity relationships of new phenolic cinnamic acid amides as selective COX-2 inhibitors". Paper presented in XXVll EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2022), 2022.
  4. Domingues, Cátia; Jarak, Ivana; Marto, Carlos Miguel; Laranjo, Mafalda; Varela, C; Tavares da Silva, Elisiário; Roleira, Fernanda; et al. "Pluronic® L121-PEI nanomicelles: a key strategy for cancer therapy.". Paper presented in EuroNanoForum 2021, 07 Health and Wellbeing, 2021.
  5. Domingues, Cátia; Jarak, Ivana; Varela, Carla; Marto, Carlos Miguel; Laranjo, Mafalda; Tavares da Silva, Elisário; Roleira, Fernanda; et al. "Pluronic L121-PEI nanosystem: making the trail for gene/drug co-delivery for cancer treatment". Paper presented in 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021.
  6. Serafim, Teresa; Sardão, Vilma; Carvalho, Filipa S.; Marques, Maria P.; Garrido, Jorge; Milhazes, Nuno; Borges, Fernanda; et al. "Antiproliferative activity of ferulic and caffeic acid derivatives on tumor cell lines ¿ Structure-function relations and direct effects on mitochondria". Paper presented in Apoptosis World 2008, From Mechanisms to Applications, Luxembourg, 2008.
  7. Serafim, Teresa; Sardão, Vilma; Holy, Jon; Marques, Maria P.; Batista de Carvalho, Luís A.E.; Garrido, Jorge; Milhazes, Nuno; et al. "Anti-proliferative profile of potential lipophilic antioxidants structurally based on the dietary antioxidants ferulic and caffeic acids". Paper presented in First Iberic Meeting on Medicinal Chemistry ¿ Anticancer Agents, Regua, Portugal, 2007.
Journal article
  1. Gomes, Ana R.; Varela, Carla L.; Pires, Ana S.; Tavares-da-Silva, Elisiário J.; Roleira, Fernanda M.F.. "Synthetic and natural guanidine derivatives as antitumor and antimicrobial agents: A review". Bioorganic Chemistry 138 (2023): 106600. http://dx.doi.org/10.1016/j.bioorg.2023.106600.
    10.1016/j.bioorg.2023.106600
  2. Ana R. Gomes; Ana S. Pires; Fernanda M. F. Roleira; Elisiário J. Tavares-da-Silva. "The Structural Diversity and Biological Activity of Steroid Oximes". Molecules (2023): https://doi.org/10.3390/molecules28041690.
    10.3390/molecules28041690
  3. Roleira, Fernanda M.F.; Costa, Saul C.; Gomes, Ana R.; Varela, Carla L.; Amaral, Cristina; Augusto, Tiago V.; Correia-da-Silva, Georgina; et al. "Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7ß substituted steroids". Bioorganic Chemistry 131 (2023): 106286. http://dx.doi.org/10.1016/j.bioorg.2022.106286.
    10.1016/j.bioorg.2022.106286
  4. Amaral, Cristina; Correia-da-Silva, Georgina; Almeida, Cristina Ferreira; Valente, Maria João; Varela, Carla; Tavares-da-Silva, Elisiário; Vinggaard, Anne Marie; Teixeira, Natércia; Roleira, Fernanda M. F.. "An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER+) Breast Cancer: Effects on Sensitive and Resistant Cell Lines". Molecules 28 2 (2023): 789. http://dx.doi.org/10.3390/molecules28020789.
    10.3390/molecules28020789
  5. Pires, Ana S.; Varela, Carla L.; Marques, Inês A.; Abrantes, Ana M.; Gonçalves, Cristina; Rodrigues, Tiago; Matafome, Paulo; et al. "Oxymestane, a cytostatic steroid derivative of exemestane with greater antitumor activity in non-estrogen-dependent cell lines". The Journal of Steroid Biochemistry and Molecular Biology 212 (2021): 105950. http://dx.doi.org/10.1016/j.jsbmb.2021.105950.
    10.1016/j.jsbmb.2021.105950
  6. Gomes, Ana R.; Pires, Ana S.; Abrantes, Ana M.; Gonçalves, Ana C.; Costa, Saul C.; Varela, Carla L.; Silva, Elisiário T.; Botelho, Maria F.; Roleira, Fernanda M.F.. "Design, synthesis, and antitumor activity evaluation of steroidal oximes". Bioorganic & Medicinal Chemistry 46 (2021): 116360. http://dx.doi.org/10.1016/j.bmc.2021.116360.
    10.1016/j.bmc.2021.116360
  7. Gomes, Ana R.; Varela, Carla L.; Tavares-da-Silva, Elisiário J.; Roleira, Fernanda M.F.. "Epoxide containing molecules: A good or a bad drug design approach". European Journal of Medicinal Chemistry 201 (2020): 112327. http://dx.doi.org/10.1016/j.ejmech.2020.112327.
    10.1016/j.ejmech.2020.112327
  8. Varela, Carla L.; Cabral, Ana M. T. D. P. V.; Barbosa, Isabel R.; Costa, Saul C.; Silva, Elisiário J. T.; Roleira, Fernanda M. F.. "Getting the Classroom Closer to Research Work: Undergraduate Students Prepare N-Hexylcinnamamide". Journal of Chemical Education (2020): http://dx.doi.org/10.1021/acs.jchemed.8b00604.
    Accepted • 10.1021/acs.jchemed.8b00604
  9. Jarak, Ivana; Varela, Carla L.; Tavares da Silva, Elisiário; Roleira, Fernanda F.M.; Veiga, Francisco; Figueiras, Ana. "Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications". European Journal of Medicinal Chemistry (2020): 112526. http://dx.doi.org/10.1016/j.ejmech.2020.112526.
    10.1016/j.ejmech.2020.112526
  10. Roleira, Fernanda. "Effects of new C6-substituted steroidal aromatase inhibitors in hormone-sensitive breast cancer cells: Cell death mechanisms and modulation of estrogen and androgen receptors". The Journal of Steroid Biochemistry and Molecular Biology (2019): http://dx.doi.org/10.1016/j.jsbmb.2019.105486.
    10.1016/j.jsbmb.2019.105486
  11. Roleira, Fernanda. "A novel GC-MS methodology to evaluate aromatase activity in human placental microsomes: a comparative study with the standard radiometric assay". Analytical and Bioanalytical Chemistry (2019): http://dx.doi.org/10.1007/s00216-019-02076-7.
    10.1007/s00216-019-02076-7
  12. Roleira, Fernanda. "New phenolic cinnamic acid derivatives as selective COX-2 inhibitors. Design, synthesis, biological activity and structure-activity relationships". Bioorganic Chemistry (2019): http://dx.doi.org/10.1016/j.bioorg.2019.103179.
    10.1016/j.bioorg.2019.103179
  13. Fernanda M. F. Roleira; Carla Varela; Cristina Amaral; Saul C. Costa; Georgina Correia-da-Silva; Federica Moraca; Giosuè Costa; et al. "C-6a- vs C-7a-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure–Activity Relationships". Journal of Medicinal Chemistry (2019): https://doi.org/10.1021/acs.jmedchem.9b00157.
    10.1021/acs.jmedchem.9b00157
  14. Roleira, Fernanda. "miR-145-loaded micelleplexes as a novel therapeutic strategy to inhibit proliferation and migration of osteosarcoma cells". (2018): http://dx.doi.org/10.1016/j.ejps.2018.07.021.
    10.1016/j.ejps.2018.07.021
  15. Roleira, Fernanda. "Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance". (2018): http://dx.doi.org/10.1016/j.jsbmb.2018.05.006.
    10.1016/j.jsbmb.2018.05.006
  16. Amaral, C.; Varela, C.L.; Maurício, J.; Sobral, A.F.; Costa, S.C.; Roleira, F.M.F.; Tavares-da-Silva, E.J.; Correia-da-Silva, G.; Teixeira, N.. "Anti-tumor efficacy of new 7a-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells". Journal of Steroid Biochemistry and Molecular Biology 171 (2017): 218-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017457908&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2017.04.002
  17. Oliveira, C.L.; Veiga, F.; Varela, C.; Roleira, F.; Tavares, E.; Silveira, I.; Ribeiro, A.J.. "Characterization of polymeric nanoparticles for intravenous delivery: Focus on stability". Colloids and Surfaces B: Biointerfaces 150 (2017): 326-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006136637&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2016.10.046
  18. Varela, C.L.; Amaral, C.; Correia-Da-Silva, G.; Costa, S.C.; Carvalho, R.A.; Costa, G.; Alcaro, S.; et al. "Exploring new chemical functionalities to improve aromatase inhibition of steroids". Bioorganic and Medicinal Chemistry 24 12 (2016): 2823-2831. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965029205&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.04.056
  19. Tavares-da-Silva, E.J.; Varela, C.L.; Pires, A.S.; Encarnação, J.C.; Abrantes, A.M.; Botelho, M.F.; Carvalho, R.A.; et al. "Combined dual effect of modulation of human neutrophils’ oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives". Bioorganic and Medicinal Chemistry 24 16 (2016): 3556-3564. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973461690&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.05.065
  20. Roleira, F.M.F.; Da Silva, E.J.T.; Pereira, J.A.C.; Ortuso, F.; Alcaro, S.; Pinto, M.M.M.. "Molecular clefts of Rebek revisited: Potential application as drug carriers for the antiviral acyclovir". Journal of Inclusion Phenomena and Macrocyclic Chemistry 83 1-2 (2015): 203-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958766762&partnerID=MN8TOARS.
    10.1007/s10847-015-0554-3
  21. Roleira, F.M.F.; Tavares-Da-Silva, E.J.; Varela, C.L.; Costa, S.C.; Silva, T.; Garrido, J.; Borges, F.. "Plant derived and dietary phenolic antioxidants: Anticancer properties". Food Chemistry 183 (2015): 235-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925860642&partnerID=MN8TOARS.
    10.1016/j.foodchem.2015.03.039
  22. Amaral, C.; Lopes, A.; Varela, C.L.; Da Silva, E.T.; Roleira, F.M.F.; Correia-Da-Silva, G.; Teixeira, N.. "Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane". International Journal of Biochemistry and Cell Biology 69 (2015): 183-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946406321&partnerID=MN8TOARS.
    10.1016/j.biocel.2015.10.024
  23. Varela, C.L.; Roleira, F.M.F.; Costa, S.C.P.; Pinto, A.S.C.T.; Martins, A.I.O.S.; Carvalho, R.A.; Teixeira, N.A.; Correia-Da-Silva, G.; Tavares-Da-Silva, E.. "Insights into the synthesis of steroidal A-ring olefins". Helvetica Chimica Acta 97 1 (2014): 39-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892750803&partnerID=MN8TOARS.
    10.1002/hlca.201300082
  24. Varela, C.L.; Amaral, C.; Tavares Da Silva, E.; Lopes, A.; Correia-Da-Silva, G.; Carvalho, R.A.; Costa, S.C.P.; Roleira, F.M.F.; Teixeira, N.. "Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line". European Journal of Medicinal Chemistry 87 (2014): 336-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907586379&partnerID=MN8TOARS.
    10.1016/j.ejmech.2014.09.074
  25. Amaral, C.; Varela, C.; Correia-Da-Silva, G.; Tavares Da Silva, E.; Carvalho, R.A.; Costa, S.C.P.; Cunha, S.C.; et al. "New steroidal 17ß-carboxy derivatives present anti-5a-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line". Biochimie 95 11 (2013): 2097-2106. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885049687&partnerID=MN8TOARS.
    10.1016/j.biochi.2013.07.023
  26. Varela, C.L.; Amaral, C.; Correia-Da-Silva, G.; Carvalho, R.A.; Teixeira, N.A.; Costa, S.C.; Roleira, F.M.F.; Tavares-Da-Silva, E.J.. "Design, synthesis and biochemical studies of new 7a-allylandrostanes as aromatase inhibitors". Steroids 78 7 (2013): 662-669. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877042832&partnerID=MN8TOARS.
    10.1016/j.steroids.2013.02.016
  27. Amaral, C.; Varela, C.; Borges, M.; Tavares Da Silva, E.; Roleira, F.M.F.; Correia-Da-Silva, G.; Teixeira, N.. "Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis". Apoptosis 18 11 (2013): 1426-1436. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886434710&partnerID=MN8TOARS.
    10.1007/s10495-013-0879-6
  28. Amaral, C.; Cunha, S.C.; Fernandes, J.O.; Tavares Da Silva, E.; Roleira, F.M.F.; Teixeira, N.; Correia-Da-Silva, G.. "Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5a-reductase activity". Talanta 107 (2013): 154-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873337500&partnerID=MN8TOARS.
    10.1016/j.talanta.2012.12.045
  29. Amaral, C.; Varela, C.; Azevedo, M.; Da Silva, E.T.; Roleira, F.M.F.; Chen, S.; Correia-Da-Silva, G.; Teixeira, N.. "Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: Aromatase inhibition and autophagy". Journal of Steroid Biochemistry and Molecular Biology 135 1 (2013): 51-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873021507&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2012.12.017
  30. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Tavares Da Silva, E.J.; Fernandes Roleira, F.M.. "N-Hexyl-3-(4-hydroxy-3,5-dimethoxyphenyl)propanamide". Acta Crystallographica Section E: Structure Reports Online 68 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862279766&partnerID=MN8TOARS.
    10.1107/S1600536812019022
  31. Andrade, L.C.R.; De Almeida, M.J.M.; Fernandes Roleira, F.M.; Varela, C.L.; Tavares Da Silva, E.J.. "6-Methyl-ideneandrost-4-ene-3,17-dione". Acta Crystallographica Section E: Structure Reports Online 68 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84860285797&partnerID=MN8TOARS.
    10.1107/S1600536812013207
  32. Varela, C.; Tavares Da Silva, E.J.; Amaral, C.; Correia Da Silva, G.; Baptista, T.; Alcaro, S.; Costa, G.; et al. "New structure-activity relationships of A-and D-ring modified steroidal aromatase inhibitors: Design, synthesis, and biochemical evaluation". Journal of Medicinal Chemistry 55 8 (2012): 3992-4002. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860267099&partnerID=MN8TOARS.
    10.1021/jm300262w
  33. Serafim, T.L.; Carvalho, F.S.; Marques, M.P.M.; Calheiros, R.; Silva, T.; Garrido, J.; Milhazes, N.; et al. "Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells". Chemical Research in Toxicology 24 5 (2011): 763-774. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956157475&partnerID=MN8TOARS.
    10.1021/tx200126r
  34. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Tavares Da Silva, E.J.; Fernandes Roleira, F.M.. "5-Androst-3-en-17ß-yl acetate". Acta Crystallographica Section E: Structure Reports Online 66 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-74349100764&partnerID=MN8TOARS.
    10.1107/S1600536809053264
  35. Roleira, F.M.F.; Siquet, C.; Orr, E.; Garrido, E.M.; Garrido, J.; Milhazes, N.; Podda, G.; et al. "Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties". Bioorganic and Medicinal Chemistry 18 16 (2010): 5816-5825. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955472869&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.06.090
  36. Roleira, F.M.F.; da Silva, T.E.J.; Carvalho, R.A.; Marques, M.P.M.. "Lithocholic acid derivative as a model for artificial receptors: A Raman study". Letters in Drug Design and Discovery 7 8 (2010): 610-617. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958453285&partnerID=MN8TOARS.
    10.2174/157018010792062731
  37. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Fernandes Roleira, F.M.; Tavares Da Silva, E.J.. "3a,4a-Ep-oxy-5a-androstan-17¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 65 4 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-64149091826&partnerID=MN8TOARS.
    10.1107/S160053680900899X
  38. Roleira, F.M.F.; Borges, F.; Andrade, L.C.R.; Paixão, J.A.; Almeida, M.J.M.; Carvalho, R.A.; Tavares da Silva, E.J.. "Activation of hydrocinnamic acids with pentafluorophenol versus pentafluorothiophenol: Reactivity towards hexylamine". Journal of Fluorine Chemistry 130 2 (2009): 169-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-58649093964&partnerID=MN8TOARS.
    10.1016/j.jfluchem.2008.09.013
  39. Andrade, L.C.R.; De Almeida, M.J.M.; Roleira, F.M.F.; Varela, C.L.; Da Silva, E.J.T.. "5a-Androst-3-en-17-one oxime". Acta Crystallographica Section C: Crystal Structure Communications 64 9 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-51049117281&partnerID=MN8TOARS.
    10.1107/S0108270108023299
  40. Cepa, M.M.D.S.; Tavares da Silva, E.J.; Correia-da-Silva, G.; Roleira, F.M.F.; Teixeira, N.A.A.. "Synthesis and biochemical studies of 17-substituted androst-3-enes and 3,4-epoxyandrostanes as aromatase inhibitors". Steroids 73 14 (2008): 1409-1415. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549118561&partnerID=MN8TOARS.
    10.1016/j.steroids.2008.07.001
  41. Cepa, M.; Correia-da-Silva, G.; da Silva, E.; Roleira, F.M.F.; Borges, M.; Teixeira, N.A.. "New steroidal aromatase inhibitors: Suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death". BMC Cell Biology 9 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-49749093721&partnerID=MN8TOARS.
    10.1186/1471-2121-9-41
  42. Cepa, M.; Correia-Da-Silva, G.; Tavares Da Silva, E.J.; Roleira, F.M.F.; Hong, Y.; Chen, S.; Teixeira, N.A.. "Molecular mechanisms of aromatase inhibition by new A, D-ring modified steroids". Biological Chemistry 389 9 (2008): 1183-1191. http://www.scopus.com/inward/record.url?eid=2-s2.0-49749135814&partnerID=MN8TOARS.
    10.1515/BC.2008.134
  43. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Fernandes Roleira, F.M.; Tavares Da Silva, E.J.. "3,17-Dioxoandrost-4-en-4-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 63 6 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34250003812&partnerID=MN8TOARS.
    10.1107/S0108270107015533
  44. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Tavares Da Silva, E.J.; Fernandes Roleira, F.M.. "Pentafluorophenyl 3-phenylprop-2-enoate". Acta Crystallographica Section E: Structure Reports Online 62 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33644974071&partnerID=MN8TOARS.
    10.1107/S1600536805040389
  45. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Tavares Da Silva, E.J.; Fernandes Roleira, F.M.. "3a,7a,12a-triformyloxy-24-nor-5ß-chol-22-ene". Acta Crystallographica Section E: Structure Reports Online 62 5 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33744530077&partnerID=MN8TOARS.
    10.1107/S1600536806012669
  46. Borges, F.; Roleira, F.; Milhazes, N.; Santana, L.; Uriarte, E.. "Simple coumarins and analogues in medicinal chemistry: Occurrence, synthesis and biological activity". Current Medicinal Chemistry 12 8 (2005): 887-916. http://www.scopus.com/inward/record.url?eid=2-s2.0-15944389028&partnerID=MN8TOARS.
    10.2174/0929867053507315
  47. Cepa, M.M.D.S.; Tavares Da Silva, E.J.; Correia-Da-Silva, G.; Roleira, F.M.F.; Teixeira, N.A.A.. "Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: Design, synthesis, and biological activity evaluation". Journal of Medicinal Chemistry 48 20 (2005): 6379-6385. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444502089&partnerID=MN8TOARS.
    10.1021/jm050129p
  48. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Fernandas Roleira, F.M.; Tavares Da Silva, E.J.. "17-Oxo-5a-androstane-3a,4ß-diyl diacetate and 17-oxo-5ß-androstane3a,4ß-di diacetate". Acta Crystallographica Section C: Crystal Structure Communications 61 3 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-30744442088&partnerID=MN8TOARS.
    10.1107/S0108270104034250
  49. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Tavares Da Silva, E.J.; Fernandes Roleira, F.M.. "17-Oxo-5ß-hydroxyandrostan-3ß-yl acetate". Acta Crystallographica Section E: Structure Reports Online 61 4 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-18544391154&partnerID=MN8TOARS.
    10.1107/S1600536805008895
  50. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Tavares da Silva, E.J.; Sá e Melo, M.L.; Fernandes Roleira, F.M.. "3ß,7a,12a-triformyloxy-24-nor-5ß-chol-22-ene". Acta Crystallographica Section C: Crystal Structure Communications 60 1 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-1242310418&partnerID=MN8TOARS.
    10.1107/S0108270103024521
  51. Santana, L.; Uriarte, E.; Roleira, F.; Milhazes, N.; Borges, F.. "Furocoumarins in medicinal chemistry. Synthesis, natural occurrence and biological activity". Current Medicinal Chemistry 11 24 (2004): 3239-3261. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844219683&partnerID=MN8TOARS.
  52. Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Roleira, F.M.F.; Sá E Melo, M.L.; Neves, A.S.C.; Da Silva, E.J.T.. "3a,4ß-Dihydroxy-5ß-androstan-17-one". Acta Crystallographica Section E: Structure Reports Online 59 1 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-18444408728&partnerID=MN8TOARS.
    10.1107/S1600536802022055
  53. Wang, J.; Watanabe, M.; Mataka, S.; Thiemann, T.; Ribeiro Morais, G.; Roleira, F.; Da Silva, E.T.; Melo E Silva, C.. "Synthesis and radiosynthesis of 17a -[p-(iodophenylethynyl)]estra-3,17ß-diols". Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 58 8 (2003): 799-804. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141729378&partnerID=MN8TOARS.
  54. Borges, F.; Fernande, E.; Roleira, F.. "Progress towards the discovery of xanthine oxidase inhibitors". Current Medicinal Chemistry 9 2 (2002): 195-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036227759&partnerID=MN8TOARS.
  55. Tavares Da Silva, E.J.; Roleira, F.M.F.; Sá E Melo, M.L.; Campos Neves, A.S.; Paixão, J.A.; De Almeida, M.J.; Silva, M.R.; Andrade, L.C.R.. "X-ray and deuterium labeling studies on the abnormal ring cleavages of a 5ß-epoxide precursor of formestane". Steroids 67 3-4 (2002): 311-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036173409&partnerID=MN8TOARS.
    10.1016/S0039-128X(01)00164-7
  56. Paixao, JA; Andrade, LCR; de Almeida, MJ; da Silva, EJT; Roleira, FMF; Melo, MLSE; Neves, ASC. "5 alpha-androst-3-en-17-one". Acta Crystallographica Section E-Structure Reports Online 57 (2001): o189-o191.
    10.1107/S1600536801001726
  57. Damas, A.M.; Roleira, F.F.; Pinto, M.M.M.. "2-[2-(hydroxyethyl)phenoxy]benzoic acid". Acta Crystallographica Section C: Crystal Structure Communications 53 8 (1997): 1143-1145. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031207195&partnerID=MN8TOARS.
  58. Borges, M.F.M.; Roleira, F.M.F.; Pinto, M.M.M.. "Simultaneous isocratic hplc separation of the diastereoisomers of caffeic, ferulic, and isoferulic acids and related coumarins". Journal of Liquid Chromatography 16 1 (1993): 149-160. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027402382&partnerID=MN8TOARS.
    10.1080/10826079308020903
  59. Borges, M.F.M.; Roleira, F.M.F.; Pinto, M.M.M.. "Erratum: Isocratic HPLC separation of scopoletin and cis/trans isomers of ferulic acid as well as isoscopoletin and cis/trans isomers of isoferulic acid (J. Liquid Chromat. 14 (12), (1991) 2307-2316)". Journal of Liquid Chromatography 15 2 (1992): http://www.scopus.com/inward/record.url?eid=2-s2.0-0026536754&partnerID=MN8TOARS.
  60. Fernanda, M.; Borges, M.; Fernanda, M.F.; Roleira, F.; Madalena, M.; Pinto, M.. "Isocratic hplc separation of scopoletin and cis/trans isomers of ferulic acid as well as isoscopoletin and cis/trans isomers of isoferulic acid". Journal of Liquid Chromatography 14 12 (1991): 2307-2316. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025733730&partnerID=MN8TOARS.
    10.1080/01483919108049693
Online resource
  1. Ana R. Gomes; Ana S. Pires; Fernanda M. F. Roleira; Elisiário J. Tavares-da-Silva. STEROID OXIMES. 2023. https://encyclopedia.pub/entry/41373.
  2. Freitas, Marisa; Proença, Carina; Ana S. Pires; Elisiário J. Tavares-da-Silva; Fernanda M. F. Roleira; Eduarda Fernandes. THE COMPLEMENTARY ANTI-INFLAMMATORY AND ANTICANCER ACTIVITY OF HYDROXYCINNAMIC ACID DERIVATIVES. 2021. https://atlasofscience.org/the-complementary-anti-inflammatory-and-anticancer-activity-of-hydroxycinnamic-acid-derivatives/.

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  1. 2024. "AROMATASE INHIBITOR, COMPOSITION AND USES THEREOF".
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2023/11/24 1,2-Epoxide steroids as a potential new treatment for different types of cancer
2023/07/16 1,2-Epoxide steroids: the future of cancer treatment? Design, synthesis, and biological studies MedChem 2023 - XII Paul Ehrlich MedChem EuroPhD Network Symposium
2021/06/29 Functionalizing Pluronic® L121 and PEI into polymeric micelles for gene/drug co-delivery for cancer therapy 4th Doctoral Congress in Engineering - symposium on “Materials Science and Engineering
2020/12 Development and characterization of a novel mixed polymeric micelle as a potential therapeutic strategy for osteosarcoma The 1st International Electronic Conference on Pharmaceutics
2020/12 Synthesis and characterization of a novel nanomicellar system Pluronic-PEI suitable for gene and drug co-delivery in cancer therapy The 1st International Electronic Conference on Pharmaceutics
2020/11/06 Discovery and optimization of new phenolic cinnamic acid derivatives as selective COX-2 inhibitors. Chemistry and structure-activity relationships IberPhenol International Conference
(Coimbra, Portugal)
2016/12/09 Estrogen-dependent breast cancer and exemestane-acquired resistance: the role of androgen receptor as a possible target XIX National Congresso of Biochemistry
(Guimarães, Portugal)
2016/09 Anti-proliferative efficacy of new steroidal AIs on sensitive and resistant breast cancer cell lines YES Meetting
(Porto, Portugal)
2016/04/28 Estrogen-dependent Breast Cancer: The Involvement of Androgen Receptor in Exemestane-Acquired Resistance 2nd ASPIC International Congress
(Porto, Portugal)
2015/09/25 Estrogen-dependent Breast Cancer: autophagy as a potential mechanism of exemestane-acquired resistance UMIB Summit 2015 - Multidisciplinary Meeting
(Porto, Portugal)
2015/09/18 Cell cycle arrest and apoptosis activation in breast cancer MCF-7aro cells induced by new aromatase inhibitors 10th Young European Scientist Meeting – YES Meeting
(Porto, Portugal)
2015/09/07 New Breakthroughs Towards Aromatase Inhibition in Breast Cancer Treatment XXIII National Meeting on Medicinal Chemistry (NMMC) and 9th Young Medicinal Chemists Symposium “Nuove Prospettive in Chimica Farmaceutica” (NPCF9)
(Salerno, Italy)
2015/05/13 Potential of New Steroidal Aromatase Inhibitiors in Breast Cancer: Anti-proliferative Effects and Cell Death Mechanisms 8th Meeting of Young Researchers at UP, IJUP`15
(Porto, Portugal)
2015/04/01 New Steroidal Aromatase Inhibitiors: Biological Effects in Hormone-dependent Breast Cancer Cell Models IV National Meeting in Post-graduation in Biological Sciences
(Aveiro, Portugal)
2014/10/11 New 7a-Allylandrostanes as Aromatase Inhibitors: Biological Effects in Hormone-dependent and Hormone-resistant Breast Cancer Cells XV Conference on Senology
(Luso, Portugal)
2014/09/10 Exploring New Chemical Functionalities to Improve Aromatase Inhibition of Steroids 22nd Conference on Isoprenoids
(Praga, Czech Republic)
2014/09/09 Exemestane Metabolites: Synthesis, Stereochemical Elucidation and Mechanism of Action in Breast Cancer
(Praga, Czech Republic)
2014/09/08 Targeting Aromatase in Breast Cancer: New Steroidal Olefins and Epoxides as Aromatase Inhibitors and Structure-Activity Relationships 22nd Conference on Isoprenoids
(Praga, Czech Republic)
2014/02/14 New 7a-Allylandrostanes as Aromatase Inhibitors: Biological Effects in Hormone-dependent and Hormone-resistant Breast Cancer Cells
(Porto, Portugal)
2014/02/05 Effects of Exemestane Metabolites in Sensitive and Resistant Breast Cancer Cells: Role of Autophagy Annual Meeting of the Portuguese Pharmacology Society
(Coimbra, Portugal)
2013/11/27 New steroidal 17beta-carboxy derivarives - Design, synthesis and evaluation as 5alpha reductase inhibitors Conferência CEF 2013
(Coimbra, Portugal)
2013/09/27 Steroidal aromatase inhibitors in breast cancer research. Structure and subtrate-guided desgn, synthesis and structure-activity relatioships (SAR) 5th BBBB International Conference
(Atenas, Greece)
2013/02/13 Exemestane metabolites: Effects on breast cancer cell proliferation and induction of cell death 6th Meeting of Young Researchers at UP
(Porto, Portugal)
2012/09/25 Structure-Activity Relationships of A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors Conferência CEF 2012
(Coimbra, Portugal)
2011/06/12 New A-Ring Steroidal Olefins and Epoxides as Aromatase Inhibitors. Synthesis and SAR Studies Second Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery
(Porto, Portugal)
2010/12/17 Structure Based Design, Synthesis and Biological Activity on Steroidal Aromatase Inhibitors. New Structure-Activity Relationships First Workshop in Medicinal Chemistry
(Porto, Portugal)
2010/02/17 Two new Aromatase Inhibitors: Biological Evaluation and Effects in an Estrogen-dependent Breast Cancer Cell Line 3º Encontro de Jovens Investigadores da U. Porto (IJUP 2010)
(Porto, Portugal)
2008/12/03 Pharmacological and Toxicological Activity of Phenolic Acids on Breast Cancer Cell Models XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica e VIII Reunião de Toxicologia
(Lisboa, Portugal)
2007/12/05 Antiproliferative Activity of Ferulic and Caffeic Acid Derivatives on Tumour Cell Lines – Stucture-Function Relations and Direct Effects on Mitochondria XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia
(Coimbra, Portugal)
2007/04/28 New 3-Deoxysteroids as Potential Supressors of Hormone-Dependent Breast Cancer First Iberic Meeting on Medicinal Chemistry-Anticancer Agents
(Régua, Portugal)
2006/12/05 The Medicinal Chemistry Artwork on the Development of New Phenolic Antioxidants XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
(Porto, Portugal)
2006/10/14 New 3-Deoxysteroids as Mechanism-Based Inhibitors of Aromatase Medicinal Chemistry in the 21st Century
(Lisboa, Portugal)
2006/10/13 The Medicinal Chemistry´s Contribution in the Discovery of Anticancer Agents Medicinal Chemistry in the 21st Century
(Lisboa, Portugal)
2006/03/23 Phenolic Derivatives: A New Challenge for Anticancer Therapy Smart Toxicology: Subcellular Targets of Anticancer Therapy - Cursos Internacionais de Toxicologia
(Coimbra, Portugal)
2005/10/06 Phenolic Derivatives: A Study Case on the Relationship Between Structure, Activity and Physicochemical Parameters Latest Advances on Anti-Inflammatory Molecules: Innovations and Perpectives, Pasteur Institute
(Paris, France)
2002/11/29 Xanthine Oxidase Inhibitors Ciclo de Seminários de 2002 do Centro de Estudos de Ciências Farmacêuticas da Faculdade de Farmácia da Universidade de Lisboa
(Lisboa, Portugal)
2002/09/06 Estrutura Cristalográfica e Conformação Molecular dos Diacetatos de 17-Oxo-5alpha-androstano-3alpha,4alpha-di-ilo e de 17-Oxo-5alpha-androstano-3alpha,4beta-di-ilo 13ª Conferência Nacional de Física - 12º Encontro Ibérico para o Ensino da Física
(Évora, Portugal)
2001/10/30 Synthetic Strategies for the Preparation of Novel Antioxidant-Estrogen Conjugates Xemes Conferences Europeénnes du Groupment des Pharmacochimistes de l´ Arc Atlantique
(Nantes, France)
2001/10/29 Synthesis and Evaluation of Steroids with Pharmaceutical Application Xemes Conferences Europeénnes du Groupment des Pharmacochimistes de l´ Arc Atlantique
(Nantes, France)
2001/05/21 Design e Síntese de Esteróides Potenciais Anti-Neoplásicos: Inibidores da Aromatase Ciclo de Seminários de 2001 do Centro de Estudos de Ciências Farmacêuticas da Faculdade de Farmácia da Universidade de Lisboa
(Lisboa, Portugal)
1998/11/13 Novas Estratégias de Síntese de um Esteróide com Actividade Anti-tumoral no Cancro da Mama: Estudo da Reactividade Química dos Intermediários de Síntese XII Encontro Luso-Galego de Química
(Porto, Portugal)
1998/02/21 Synthesis and Evaluation of Compounds with Pharmaceutical Application 1.st Meeting Opportunities for Pharmaceutical R&D in Portugal
(Oeiras, Portugal)
1995/07/15 Vidarabine: NMR Studies of Self-association and Complex Formation with a Molecular Cleft 1º Encontro Nacional de Química Orgânica
(Braga, Portugal)
1993/04/20 Determinação, por HPLC, das constantes de associação entre o Aciclovir e Fendas Moleculares de Rebek Workshop de HPLC (Merck)
(Porto, Portugal)
1992/07/10 Fendas Moleculares de Rebek: Receptores Artificiais para o Aciclovir Encontro de Jovens Investigadores em Ciências Farmacêuticas
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/12/01 - Current DESIGN AND SYNTHESIS OF ANTI-INFLAMMATORY DRUGS BASED ON CINNAMIC ACID DERIVATIVES TARGETING COX-2
Supervisor
Universidade de Coimbra, Portugal
2021/01/01 - Current Design, synthesis and biological activity evaluation of functionalized steroids as anticancer agents
Supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2020 Synthesis of amides of 4-hydroxy-3,5-di-tert-butylcinnamic acid as potential anti-inflammatory drugs
Supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2019 ANTITUMOR ACTIVITY EVALUATION OF SYNTHETIC STEROIDAL OXIMES AND EPOXIDES
Supervisor
 Mestrado em Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Cancro do cólon e suas terapêuticas
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - 2018 Artrite Reumatóide: abordagens terapêuticas
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - 2018 Derivados do ácido cinâmico. Contribuição para a investigação dos inibidores das ciclo-oxigenases
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016 - 2018 Synthesis of derivatives of cinnamic acids as potential anti-inflammatory drugs
Supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016 - 2017 Doença de crohn: uso de pre e probióticos na terapêutica
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - 2016 O uso de Esteróides Androgénicos-Anabolizantes em química terapêutica e o seu uso ilícito no mercado de venda paralelo
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2016 Development of an amidation reaction to introduce in Organic Chemistry Laboratorial Classes of the Pharmaceutical Sciences Course
Co-supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2015 Hormonoterapia no cancro da mama
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2015 Terapia fotodinâmica: Conceitos Básios e Aplicações
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2015 Synthesis of steroidal aromatase inhibitors for breast cancer treatment
Co-supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2015 Synthesis of steroidal aromatase inhibitors for breast cancer treatment
Supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012 - 2014 Design, synthesis and biochemical studies of 17ß-carboxamyde derivatives of formestane as aromatase inhibitors
Supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012 - 2013 Novas terapias no tratamento do cancro: A evolução dos anticorpos monoclonais
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012 - 2013 Design, synthesis and biochemical studies of 7alpha-vinyl derivatives of androstenedione as aromatase inhibitors
Co-supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2013 DESIGN, SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS STUDIES ON STEROIDAL AROMATASE AND 5ALPHA-REDUCTASE INHIBITORS AS ANTI-TUMORS
Supervisor
 Química Farmacêutica (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2012 Vitaminas – Vantagens, desvantagens e aconselhamento ao doente
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2012 O papel do Farmacêutico no acompanhamento/aconselhamento de doentes com SIDA
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2012 Acidente vascular cerebral: Terapêutica hospitalar e em ambulatório
Supervisor
 Mestrado Integrado em Ciências Farmaêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2012 Design, synthesis and biochemical studies of 4,5-epoxy- and 4,5-cyclopropane-3-deoxyandrostan-17-one derivatives as aromatase inhibitors
Co-supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2012 Design, synthesis and biochemical studies of 3-deoxy analogues of ¿6-androstenedione and its 7a-allyl derivatives as aromatase inhibitors
Co-supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2011 Terapia de substituição hormonal: Alternativa para mulheres que tiveram cancro de mama hormono-dependente
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2011 Gestão da Contaminação Cruzada por Beta lactâmicos
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (MICF up-grade) (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2011 Synthesis of potential aromatase and 5alpha-reductase inhibitors
Supervisor
 Estágios de iniciação à investigaçáo em colaboração com o Núcleo de Estudantes de Farmácia - NEF da FFUC (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2010 Os inibidores da 5a-reductase no tratamento da alopécia e riscos associados
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2010 Opções terapêuticas para tratamento adjuvante do cancro da mama
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - 2010 SYMTHESIS OF ANTITUMOR STEROIDS WITH ACTION ON ENZYMES RELATED TO BREAST AND PROSTATE CANCERS
Supervisor
 Bolseira de Integração na Investigação (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2002 - 2003 Esterificação da função álcool do éster metílico do ácido litocólico. Síntese, purificação e elucidação estrutural dos produtos
Co-supervisor
 Disciplina de Síntese Química e Enzimática (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2001 - 2002 Esterificação da função carboxilo do ácido litocólico. Síntese, purificação e elucidação estrutural dos produtos
Supervisor
 Disciplina de Síntese Química e Enzimática (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
1998 - 1999 Descarboxilação oxidativa do ácido cólico com os grupos hidroxilo protegidos. Síntese, purificação e elucidação estrutural dos produtos
Supervisor
 Disciplina de Síntese Química e Enzimática (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal
1997 - 1998 Protecção dos grupos hidroxilo do ácido cólico. Síntese, purificação e elucidação estrutural dos produtos
Supervisor
 Disciplina de Síntese Química e Enzimática (Scientific initiation)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023/10 - Current Bioorganic Chemistry
2022/02/14 - 2022/02/25 Jornal of Medicinal Chemistry
2020/12/17 - 2020/12/29 Critical Reviews in Food Science and Nutrition (1549-7852) Informa UK (Taylor & Francis)
2020/11 - 2020/11 Future Medicinal Chemistry (1756-8927) Newlands Press Ltd
2020/07 - 2020/07 Brazilian Journal of Pharmaceutical Sciences (1984-8250) SciELO
2019 - 2019 Journal of Medicinal Chemistry
2019 - 2019 Bioorganic Chemistry
2019 - 2019 Bioorganic Chemistry
2019 - 2019 Bioorganic Chemistry
2018 - 2018 Journal of Medicinal Chemistry
2018 - 2018 Journal of Medicinal Chemistry
2017 - 2017 Journal of Medicinal Chemistry
2016 - 2016 Journal of Medicinal Chemistry
2015 - 2015 Journal of Medicinal Chemistry (1520-4804) American Chemical Society
2015 - 2015 Journal of Medicinal Chemistry
2014 - 2014 Molecules (1420-3049) MDPI AG
2014 - 2014 European Journal of Medicinal Chemistry
2014 - 2014 Hormone and Metabolic Research
2014 - 2014 Bioorganic and Medicinal Chemistry
2013 - 2013 Expert Opinion on Therapeutic Patents
2012 - 2012 Journal of Pharmacy Pharmacology
2011 - 2011 Molecules (1420-3049) MDPI AG
2010 - 2010 Current Organic Synthesis
2010 - 2010 European Journal of Medicinal Chemistry

Association member

Society Organization name Role
2019 - 2024 Sociedade Portuguesa de Química
1991 - 2024 Ordem dos Farmacêuticos
Distinctions

Award

1992 Prémio Carlos Richter
1992 Prémio Eng. António de Almeida
Fundação Engenheiro António de Almeida, Portugal
1992 Prémio Sociedade Portuguesa Lusitana
Ordem dos Farmaceuticos, Portugal
1992 Prémio Nuno Salgueiro
1989 Prémio Marques de Carvalho