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I am a bioinformatician but as I used to say, ¿above all I am a biologist¿!! I have a BSc in Biology and a MSc in Molecular and Cellular Biology, both awarded by the University of Aveiro. Nevertheless, my urgent need to know more about the emerging field - at the time - Bioinformatics it took me to the University of Minho where I completed a MSc in Bioinformatics. My professional path started in Spain where I entered in my first fellowship at the end of my stay at the University of Vigo ¿ Campus of Ourense. After that I started working as a freelancer for a company of Switzerland where I developed my programming skills. I got in later into an internship in Oporto at a diagnose facility of rare diseases (CGPP). Still, in Oporto I joined into my second fellowship, in the field of population genetics applied to virus and cancer, at Ipatimup - i3S. I entered in another fellowship connected to a project called Metafluidics, in Cantanhede at a facility of NGS ¿ Genoinseq, that makes part of CNC of University of Coimbra. So far, I have published 5 scientific articles in peer-reviewed journals (2 as first author) in the areas of, microbiology network mining, 2 in population genetics of virus and one in taxonomy classification of a new bacterial species (Tepidimonas xarontis) as well as one in the microbiology of freshwaters. I am currently in a PhD studentship granted by Fundação para a Ciência e Tecnologia in a project entitled "A computational framework towards the study of metabolic interactions of the gut microbiome and the human host in Type 2 Diabetes" and it will end in 2025.
Identification

Personal identification

Full name
Nadine Castelhano Santos

Citation names

  • Castelhano, N.
  • Santos, N.

Author identifiers

Ciência ID
321D-844E-D1E1
ORCID iD
0000-0002-6181-6471

Websites

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2020/10/01 - 2025/02/28
Ongoing
Programa doutoral em Engenharia Biomédica (Doutoramento)
Universidade do Minho, Portugal
"A computational framework towards the study of metabolic interactions of the gut microbiome and the human host in Type 2 Diabetes" (THESIS/DISSERTATION)
2011/09/15 - 2013/12/16
Concluded
Mestrado em Bioinformática (Mestrado)
Universidade do Minho Escola de Engenharia, Portugal
"Mining quorum sensing in the opportunistic pathogens P. aeruginosa and C. albicans" (THESIS/DISSERTATION)
16
2013/02/01 - 2013/09/30
Concluded
LPP/ERASMUS grant (Master)
Universidade de Vigo - Campus Ourense, Spain
16
2009/09/15 - 2011/07/06
Concluded
Mestrado em Biologia Aplicada (Mestrado)
Universidade de Aveiro, Portugal
"SARP 2 as a molecular marker of human sperm morphology" (THESIS/DISSERTATION)
17
2004/09/15 - 2009/06/23
Concluded
Licenciatura em Biologia (1º Ciclo) (Licenciatura)
Universidade de Aveiro, Portugal
"Flora do distrito de Aveiro: Adianthaceae - Urticaceae" (THESIS/DISSERTATION)
15
Affiliation

Science

Category
Host institution
Employer
2020/10/01 - 2025/02/28 Research Trainee (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Minho, Portugal
(...)

Others

Category
Host institution
Employer
2019/03/25 - 2020/05/31 Research contract - H2020-LEIT-BIO-2015-1, nu. 685474 - Metafluidics- Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/07/01 - 2017/07/01 Research contract - NORTE-01-0145-FEDER-000029 - "Mapping genetic and phenotypic heterogeneity in HER2 positive cancers to anticipate and counteract resistance phenotypes." Supervisor: Miguel Arenas Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/05/01 - 2016/06/01 Bioinformatician - freelancer Biomarker discovery on several types of cancer, such as breast and prostate cancer, using R as programming language, data mining techniques and exploratory data analysis SimplicityBio SA, Switzerland
2015/07/01 - 2016/05/31 Bioinformatician-trainee (IEFP) Project(s):Development of a web applications:RDG creator, using perl, cgi, xml and HTML, web api of Ensembl (genomic sequences, and variants) CGPP (Centro de Genética Preditiva e Preventiva)–IBMC I3S - Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2015/03/31 Bioinformatician - Trainee (Volunteer) Project(s): Variant calling study on tomato. Working on in-house pipeline written in python integrated with GATK toolkit and bash language Sequentia Biotech, Spain
2013/10/01 - 2013/12/31 Research contract - INOU13-07 Title: Framework para a análise de datos microbiolóxicos de patóxenos con gran incidencia hospitalaria Funding agency: Universidad de Vigo Universidade de Vigo - Campus Ourense, Spain
2011/03/31 - 2011/07/06 CBC Researcher on project: SARP 2 as a molecular marker of human sperm morphology Universidade de Aveiro, Portugal
2008/09/15 - 2009/05/15 Traineeship: food and water microbiology, animal microbiology (helping to prepare vaccines after pathogen isolation) Controlvet, Portugal
Projects

Grant

Designation Funders
2020/10/01 - 2025/02/28 A computational framework towards the study of metabolic interactions of the gut microbiome and the human host in Type 2 Diabetes
2020.06810.BD
PhD Student Fellow
Universidade do Minho, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/03/25 - 2020/05/31 Metafluidics- Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics
H2020-LEIT-BIO-2015-1, nu. 685474
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Horizon 2020
2016/07 - 2017/07 Mapping genetic and phenotypic heterogeneity in HER2 positive cancers to anticipate and counteract resistance phenotypes
NORTE-01-0145-FEDER-000029
Research Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
NORTE2020: Portuguese Government & EU (Porto, Portugal)
2013/10 - 2013/12 INOU13-07 - Framework para a análise de datos microbiolóxicos de patóxenos con gran incidencia hospitalaria
INOU13-07
Research Fellow
Universidade de Vigo - Campus Ourense, Spain
N/A
Outputs

Publications

Conference poster
  1. Castelhano, Nadine (321D-844E-D1E1); Conceição Egas; Hugo Froufe; Luciana Albuquerque; Milton Costa. "P41: Lignocellulose degradation in wood and urban-waste composts analysed by functional metagenomics". Paper presented in Microbiotec 2019 - Congress of Microbiology and Biotechnology, 2019.
  2. Gabriela Simões; Castelhano, N.; Hugo Froufe; Cristina Barroso; Luciana Albuquerque; Milton S. da Costa; Conceiçao Egas. "P44: Microorganisms from sun-exposed stone wall microorganisms as a new source for the production of compatible solutes". Paper presented in Microbiotec 2019 - Congress of Microbiology and Biotechnology, 2019.
  3. Gabriela Simões; Castelhano, N.; Hugo Froufe; Cristina Barroso; Luciana Albuquerque; Milton S. da Costa; Conceiçao Egas. "P46: Analysis of the functional metagenome of two Portuguese hot springs identify the potential for compatible solutes synthesis". Paper presented in Microbiotec 2019 - Congress of Microbiology and Biotechnology, 2019.
Journal article
  1. Nuno F.F. Moreira; Sara Ribeirinho-Soares; Ana Teresa Viana; Cátia A.L. Graça; Ana Rita L. Ribeiro; Nadine Castelhano; Conceição Egas; et al. "Rethinking water treatment targets: Bacteria regrowth under unprovable conditions". Water Research (2021): https://doi.org/10.1016/j.watres.2021.117374.
    10.1016/j.watres.2021.117374
  2. Luciana Albuquerque; Castelhano, Nadine (321D-844E-D1E1); Pedro Raposo; Hugo J. C. Froufe; Igor Tiago; Rita Severino; Inês Roxo; et al. "Comparative genome sequence analysis of several species in the genus Tepidimonas and the description of a novel species Tepidimonas charontis sp. nov.". International Journal of Systematic and Evolutionary Microbiology 70 3 (2020): 1596-1604. https://doi.org/10.1099/ijsem.0.003942.
    10.1099/ijsem.0.003942
  3. Castelhano, Nadine (321D-844E-D1E1); Natalia M Araujo; Miguel Arenas. "Heterogeneous recombination among Hepatitis B virus genotypes.". Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2017): http://europepmc.org/abstract/med/28827173.
    10.1016/j.meegid.2017.08.015
  4. Miguel Arenas; Natalia M Araujo; Catarina Branco; Castelhano, Nadine (321D-844E-D1E1); Eduardo Castro-Nallar; Perez-Losada, Marcos. "Mutation and recombination in pathogen evolution: Relevance, methods and controversies.". Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2017): http://europepmc.org/abstract/med/28951202.
    10.1016/j.meegid.2017.09.029
  5. Castelhano Santos N; Pereira MO; Lourenço A. "Pathogenicity phenomena in three model systems: from network mining to emerging system-level properties.". Briefings in Bioinformatics (2015): http://europepmc.org/abstract/med/24106130.
    10.1093/bib/bbt071
Thesis / Dissertation
  1. Castelhano, N.. "Mining quorum sensing in the opportunistic pathogens P. aeruginosa and C. albicans". Master, Universidade do Minho Departamento de Engenharia Biológica, 2013. https://pdfs.semanticscholar.org/85f1/30efd91a160871c63c00986b317fbb43040c.pdf.
  2. Castelhano, N.. "SARP 2 as a molecular marker of human sperm morphology". Master, Universidade de Aveiro Departamento de Biologia, 2011. https://ria.ua.pt/bitstream/10773/5800/1/completo.pdf.
Activities

Event organisation

Event name
Type of event (Role)
Institution / Organization
2012/03/14 - 2012/03/15 2nd Edition of Bioinformatics Open Days (2012/03/14 - 2012/03/15) Universidade do Minho, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/04/12 - 2023/04/14 ELIXIR Systems Biology Community F2F/hybrid & Implementation Study Kickoff meeting, participation on the workshop - Microbiome Modeling
Workshop
ELIXIR Systems Biology Community F2F/hybrid & Implementation Study Kickoff meeting
2023/01/12 - 2023/01/13 III Metabolism Aging and Disease Meeting - junior talks – Gut microbiome and type 2 diabetes patients
Congress
III Metabolism Aging and Disease Meeting
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/11/21 - 2022/11/21 Think Thank com a Pfizer - Digital Health
Round table
Think Thank com a Pfizer - Digital Health
Biocant Associação de Transferência de Tecnologia, Portugal
2022/11/08 - 2022/11/08 Webinar: Python para Data Science – GADES Solutions
Workshop
Webinar: Python para Data Science
2022/10/25 - 2022/10/25 Workshop Metabolism and mathematical models: Two for a tango | 2nd Edition
Workshop
Workshop Metabolism and mathematical models: Two for a tango | 2nd Edition
2021/11/25 - 2021/11/25 Introdução a sistemas lineares em NumPy e SciPy - NEBIUM online course
Workshop
Introdução a sistemas lineares em NumPy e SciPy
Universidade do Minho, Portugal
2021/10/20 - 2021/10/20 The gut microbiota and diabetes - Professor Fredrik Bäck - University of Gothenburg
Conference
The gut microbiota and diabetes - Professor Fredrik Bäck
2021/06/30 - 2021/07/09 S2MS Summer school in metabolic modeling - online course provided by NEBIUM from Univeristy of Minho
Workshop
S2MS Summer school in metabolic modeling
Universidade do Minho, Portugal
2020/11/18 - 2020/11/18 Oral presentation "A computational framework towards the study of metabolic interactions of the gut microbiome and the human host in Type 2 Diabetes" at 1st retreat MAD (Metabolism Aging and Disease) meeting
Congress
1st retreat MAD meeting
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/03/07 - 2020/03/08 Gut Microbiota for Health - World Summit 2020
Congress
2019/12/05 - 2019/12/07 Microbiotec 2019 - Congress of Microbiology and Biotechnology
Congress
Universidade de Coimbra, Portugal
2017/07/04 - 2017/07/04 IV Annual BiotechHealth Symposium
Conference
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/05/29 - 2017/06/17 VII Workshop of Cancer Research: Biological and molecular basis
Workshop
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/10/06 - 2014/10/09 Transcriptome Assembly, Automatic Annotation and Data Mining Subjects: RNA-seq and functional annotation practical workshop on Blast2GO Duration: 4 days
Workshop
Instituto Gulbenkian de Ciência, Portugal
2014/02/25 - 2014/02/26 Analysis of Biological data with R Duration: 15 hours
Workshop
Universidade do Minho Centro de Engenharia Biológica, Portugal
2013/11/15 - 2013/11/17 Biofilm transcriptomics - Quantifying gene expression from pathogenic bacterial biofilms (7th edition)
Workshop
Universidade do Minho Centro de Engenharia Biológica, Portugal
2007/02 - 2007/03 Scientifc illustration course with Pedro Salgado
Workshop
Universidade de Aveiro Departamento de Biologia, Portugal
Distinctions

Award

2013 LPP/ERASMUS grant