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Jani Silva has a degree in Clinical Analyses and Public Health from the Faculty of Health Sciences of the Fernando Pessoa University, a master's degree in Clinical Microbiology from the same institution, and a PhD in Biomedicine from the Faculty of Medicine of the University of Porto. She did post-doctoral research at the Molecular Oncology and Viral Pathology Group of the Research Centre of the Portuguese Institute of Oncology-Porto. She has carried out various research projects in the areas of biomedicine and molecular oncology, including the definition of pharmacogenomic and epigenetic profiles and in vitro studies of the anti-tumour and immunomodulatory activity of chemical compounds. As a result of her scientific activity, she has published 21 specialized journals, 3 book chapters, 13 invited oral communications, and 8 poster communications, and supervised several undergraduate and postgraduate students. She is currently Auxiliary Researcher at AQUAVALOR – Centro de Valorização e Transferência de Tecnologia da Água (CoLAB).
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Identification

Personal identification

Full name
Jani Viviana Alves Vital da Silva

Citation names

  • Silva, Jani

Author identifiers

Ciência ID
3419-1190-8347
ORCID iD
0000-0001-5868-4669
Researcher Id
D-3814-2017

Email addresses

  • jani.silva@aquavalor.pt (Professional)

Addresses

  • AQUAVALOR Centro de Valorização e Transferência de Tecnologia da Água (CoLAB), Rua Dr. Júlio Martins Nº1 5, 5400-342 , Chaves, Chaves, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2012 - 2017
Concluded
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"“Sexually transmitted infections in women of reproductive age: epidemiology, risk factors and genetic susceptibility profile”" (THESIS/DISSERTATION)
 Aprovada com Distinção
2009 - 2011
Concluded
 Microbiologia Clínica (Mestrado)
Universidade Fernando Pessoa Faculdade de Ciências da Saúde, Portugal
"“Caracterização molecular de agentes infeciosos associados ao desenvolvimento de cancro do colo do útero em jovens do Norte de Portugal: estudo do vírus do papiloma humano e Chlamydia trachomatis”" (THESIS/DISSERTATION)
2003 - 2008
Concluded
 Análises Clínicas e de Saúde Pública (Licenciatura)
Universidade Fernando Pessoa Faculdade de Ciências da Saúde, Portugal
Affiliation

Science

Category
Host institution 		Employer
2020/09/01 - Current Auxiliary Researcher (Research) AquaValor, Portugal
2018/07 - 2020/08 Postdoc (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2012/01 - 2018/06 Researcher (Research) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2009/07 - 2010/12 Research Trainee (Research) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Projects

Grant

Designation Funders
2018/07 - 2020/08 Circulating MicroRNAs as prognostic biomarkers in prostate cancer patients treated with second generation androgen receptor-axis-targeted (ARAT) agents
CI-IPOP-BPD2018/UID/DTP/00776/POCI-01-0145-FEDER-006868-GOMPV
Post-doc Fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Concluded

Contract

Designation Funders
2023/10 - Current OralTherm - Saúde oral pela água termal
PD23-00018
Researcher
AquaValor, Portugal
 Fundação 'la Caixa'

Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2023/09/01 - Current FINANCIAMENTO BASE - LABORATÓRIO COLABORATIVO- Missão Interface
Investimento RE-C05-i02 – Missão Interface N.º 01/C05-i02/2022
Researcher
2021 - Current Aquae Vitae
PD20-00003
Researcher
AquaValor, Portugal
 Fundação 'la Caixa'
Ongoing
2020/09/01 - 2023/08/31 Infraestruturas Tecnológicas (IT) da Região Norte: Centros de Valorização e Transferência de Tecnologia (CVTT-AquaValor)
NORTE-01-0246-FEDER-000053
Researcher
Ongoing
2020/09/01 - 2023/08/31 Emprego altamente qualificado nas empresas ou em COLABS - Contratação de Recursos Humanos Altamente Qualificados (PME ou CoLAB)
NORTE-06-3559-FSE-000095
Researcher
AquaValor, Portugal
2020 - 2022 Observatório da Atividade Termal
PV19-00034
Researcher
AquaValor, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Silva, Jani; Garcia, Juliana; Guimarães, Rafaela; Palito, Cátia; Lemos, André; Barros, Lillian; Alves, Maria José. "Alkaloids from Fungi". In Natural Secondary Metabolites, 529-554. Springer International Publishing, 2023.
    10.1007/978-3-031-18587-8_16
  2. Garcia, Juliana; Silva, Jani; Gouvinhas, Irene; Guimarães, Rafaela; Bovolini, António; Saavedra, Maria José; Alves, Maria José. "Sulfur-Containing Compounds from Fungi". In Natural Secondary Metabolites, 647-672. Springer International Publishing, 2023.
    10.1007/978-3-031-18587-8_20
  3. Silva, Jani. "Chlamydia silent epidemic disease: From research evidence to prevention". 31-58. 2014.
Conference poster
  1. Silva, Jani. "High prevalence of high-risk HPV infection in university students from the Northeast Region of Portugal using self-sampling". Paper presented in 22nd European Society for Clinical Virology, 2019.
  2. Silva, Jani. "Is over-reporting condom use related to increased prevalence of human papillomavirus? The role of Y chromosome DNA.". Paper presented in 30th International Papillomavirus Conference & Clinical and Public Health Workshops, 2015.
  3. Silva, Jani. "Cervicovaginal coinfections with human papillomavirus and Chlamydia trachomatis in reproductive-age women.". Paper presented in 30th International Papillomavirus Conference & Clinical and Public Health Workshops, 2015.
  4. Silva, Jani. "Genital microbiome and human papillomavirus infection: the case of mycoplasmas.". Paper presented in 30th International Papillomavirus Conference & Clinical and Public Health Workshops, 2015.
  5. Silva, Jani. "Y chromosome DNA presence in cervicovaginal self-collected samples: implications for epitheliotropic sexually transmitted infections prevalence.". Paper presented in 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2014.
  6. Silva, Jani. "Is Chlamydia trachomatis related to human papillomavirus infection in young women of southern european population?". Paper presented in 2º Encontro de Doutorandos, Faculdade de Medicina da Universidade do Porto, 2012.
  7. Silva, Jani. "Prevalence and risk factors for C. trachomatis infection in adolescents and university women from north Portugal.". Paper presented in 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2012.
  8. Silva, Jani. "HPV infection in adolescents and university students from Portugal: self-sampling". Paper presented in 27th International Papillomavirus Conference, 2011.
Journal article
  1. Gouvinhas, I.; Silva, J.; Alves, M. J.; Garcia, J.. "The most dreadful mushroom toxins". EXCLI Journal 23 (2024): 833-859.
    Open access • Published
  2. Jani Silva; Valéria Tavares; Ana Afonso; Juliana Garcia; Fátima Cerqueira; Rui Medeiros. "Plasmatic MicroRNAs and Treatment Outcomes of Patients with Metastatic Castration-Resistant Prostate Cancer: A Hospital-Based Cohort Study and In Silico Analysis". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24109101.
    10.3390/ijms24109101
  3. Jani Silva; José Martins; Cristina Nicomédio; Catarina Gonçalves; Cátia Palito; Ramiro Gonçalves; Paula Odete Fernandes; Alcina Nunes; Maria José Alves. "A Novel Approach to Assess Balneotherapy Effects on Musculoskeletal Diseases—An Open Interventional Trial Combining Physiological Indicators, Biomarkers, and Patients’ Health Perception". Geriatrics (2023): https://doi.org/10.3390/geriatrics8030055.
    10.3390/geriatrics8030055
  4. José Martins; Catarina Gonçalves; Jani Silva; Ramiro Gonçalves; Frederico Branco. "Digital Ecosystem Model for GIAHS: The Barroso Agro-Sylvo-Pastoral System". Sustainability (2022): https://www.mdpi.com/2071-1050/14/16/10349.
    10.3390/su141610349
  5. Guimarães, Rafaela; Milho, Catarina; Liberal, Ângela; Silva, Jani; Fonseca, Carmélia; Barbosa, Ana; Ferreira, Isabel C. F. R.; Alves, Maria José; Barros, Lillian. "Antibiofilm Potential of Medicinal Plants against Candida spp. Oral Biofilms: A Review". Antibiotics 10 9 (2021): 1142. http://dx.doi.org/10.3390/antibiotics10091142.
    10.3390/antibiotics10091142
  6. "Effect of 1-Carbaldehyde-3,4-dimethoxyxanthone on Prostate and HPV-18 Positive Cervical Cancer Cell Lines and on Human THP-1 Macrophages". Molecules 26 12 (2021): 3721-3721. http://dx.doi.org/10.3390/molecules26123721.
    10.3390/molecules26123721
  7. Silva, Jani. "The prevalence and risk-factors of oral HPV DNA detection among HIV-infected men between men who have sex with men and heterosexual men". Infectious Diseases (2020): 1-12. http://dx.doi.org/10.1080/23744235.2020.1811373.
    10.1080/23744235.2020.1811373
  8. Silva, Jani. "YB-1 variant and androgen receptor axis-targeted agents in metastatic castration-resistant prostate cancer patients". Pharmacogenomics 21 13 (2020): 919-928. http://dx.doi.org/10.2217/pgs-2020-0008.
    10.2217/pgs-2020-0008
  9. Silva, Jani. "Prevalence of Neisseria gonorrhoeae and Trichomonas vaginalis in Portuguese women of childbearing age.". Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (2020): https://doi.org/10.1080/01443615.2020.1736014.
    10.1080/01443615.2020.1736014
  10. Silva, Jani. "Aggressive prostate cancer phenotype and genome-wide association studies: where are we now?". Pharmacogenomics (2020): http://dx.doi.org/10.2217/pgs-2019-0123.
    10.2217/pgs-2019-0123
  11. Silva, Jani. "Human papillomavirus prevalence and distribution in self-collected samples from female university students in Maputo". International Journal of Gynecology & Obstetrics (2020): http://dx.doi.org/10.1002/ijgo.13126.
    10.1002/ijgo.13126
  12. Silva, Jani. "Genital mycoplasmas and ureaplasmas in cervicovaginal self-collected samples of reproductive-age women: prevalence and risk factors". International Journal of STD & AIDS (2018): http://dx.doi.org/10.1177/0956462418774209.
    10.1177/0956462418774209
  13. Silva, Jani; Cerqueira, Fátima; Medeiros, Rui. "Acceptability of self-sampling in Portuguese women: the good, the bad or the ugly?". Sexual Health 14 3 (2017): 298. http://dx.doi.org/10.1071/sh16077.
    10.1071/sh16077
  14. Silva, Jani; Cerqueira, Fátima; Medeiros, Rui. "Y chromosome DNA in cervicovaginal self-collected samples of childbearing age women: Implications for epitheliotropic sexually transmitted infections?". Life Sciences 139 (2015): 62-68. http://dx.doi.org/10.1016/j.lfs.2015.07.027.
    10.1016/j.lfs.2015.07.027
  15. Nazareth, N.; Magro, F.; Appelberg, R.; Silva, J.; Gracio, D.; Coelho, R.; Cabral, J.M.; et al. "Increased viability but decreased culturability of Mycobacterium avium subsp. paratuberculosis in macrophages from inflammatory bowel disease patients under Infliximab treatment". Medical Microbiology and Immunology 204 6 (2015): 647-656. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942197352&partnerID=MN8TOARS.
    10.1007/s00430-015-0393-2
  16. Vieira, Mariana; Sequeira, Teresa; Teles, Ana; Silva, Jani; Cerqueira, Fátima; Medeiros, Rui; Silveira, Augusta. "# 58. HPV: aferição de prevalência na cavidade oral de um grupo de mulheres portuguesas". Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial 55 (2014): e27. http://dx.doi.org/10.1016/j.rpemd.2014.11.168.
    10.1016/j.rpemd.2014.11.168
  17. Silva, Jani; Cerqueira, Fátima; Medeiros, Rui. "Response to: Chlamydia trachomatis, human papillomavirus, bacterial vaginosis and cervical neoplasia". Archives of Gynecology and Obstetrics 289 6 (2014): 1157-1158. http://dx.doi.org/10.1007/s00404-014-3215-7.
    10.1007/s00404-014-3215-7
  18. Nazareth, N.; Magro, F.; Silva, J.; Duro, M.; Gracio, D.; Coelho, R.; Appelberg, R.; Macedo, G.; Sarmento, A.. "Infliximab therapy increases the frequency of circulating CD16+monocytes and modifies macrophage cytokine response to bacterial infection". Clinical and Experimental Immunology 177 3 (2014): 703-711. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904751087&partnerID=MN8TOARS.
    10.1111/cei.12375
  19. Silva, Jani; Cerqueira, Fátima; Medeiros, Rui. "Chlamydia trachomatis infection: implications for HPV status and cervical cancer". Archives of Gynecology and Obstetrics 289 4 (2013): 715-723. http://dx.doi.org/10.1007/s00404-013-3122-3.
    10.1007/s00404-013-3122-3
  20. Silva, Jani; Cerqueira, Fátima; Ribeiro, Joana; Sousa, Hugo; Osório, Teresa; Medeiros, Rui. "Is Chlamydia trachomatis related to human papillomavirus infection in young women of southern European population? A self-sampling study". Archives of Gynecology and Obstetrics 288 3 (2013): 627-633. http://dx.doi.org/10.1007/s00404-013-2771-6.
    10.1007/s00404-013-2771-6
  21. Silva, Jani; Ribeiro, Joana; Sousa, Hugo; Cerqueira, Fátima; Teixeira, Ana Luisa; Baldaque, Ines; Osório, Teresa; Medeiros, Rui. "Oncogenic HPV Types Infection in Adolescents and University Women from North Portugal: From Self-Sampling to Cancer Prevention". Journal of Oncology 2011 (2011): 1-8. http://dx.doi.org/10.1155/2011/953469.
    10.1155/2011/953469
Thesis / Dissertation
  1. Silva, Jani. "Sexually transmitted infections in women of reproductive age: epidemiology, risk factors and genetic susceptibility profile". PhD, Universidade do Porto Faculdade de Medicina, 2017.
  2. Silva, Jani. "Caracterização molecular de agentes infeciosos associados ao desenvolvimento de cancro do colo do útero em jovens do Norte de Portugal: estudo do vírus do papiloma humano e Chlamydia trachomatis". Master, Universidade Fernando Pessoa Faculdade de Ciências da Saúde, 2012.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - 2020 Detection and genotyping of Chlamydia trachomatis in university women
Co-supervisor
 Mestrado em Microbiologia Aplicada (Master)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2019 - 2019 Prevalência de infeção por Vírus do Papiloma Humano em estudantes da Escola Superior de Saúde da Região Nordeste utilizando a metodologia de auto-colheita
Co-supervisor
 Licenciatura em Ciências Biomédicas Laboratoriais (Degree)
Instituto Politécnico de Bragança, Portugal
2019 - 2019 Estudo da prevalência do HPV na cavidade oral de estudantes do ensino superior
Co-supervisor
 Ciências Biomédicas Laboratoriais (Degree)
Instituto Politécnico de Bragança, Portugal
2018 - 2019 Aggressive prostate cancer GWAS SNPs and its association with clinical outcome
Co-supervisor
 Mestrado em Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2017 Vírus do Papiloma humano e outros tipos de infeções transmitidas sexualmente em universitárias em Maputo, Moçambique: utilização de um método de auto-colheita
Co-supervisor
 Mestrado em Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2014 Pesquisa de Poliomavírus em amostras cervicovaginais
Co-supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade Fernando Pessoa Faculdade de Ciências da Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/12/02 - 2018/12/03 Participação como palestrante - Congresso Internacional EUROGIN 2018
Congress
 Congresso Internacional EUROGIN 2018
2016/04 - 2016/04 Participação como palestrante - III Jornadas de Ciências Biomédicas- CESPU, Porto III Jornadas de Ciências Biomédicas- CESPU, Porto
2016/03 - 2016/03 Participação como palestrante - II Simpósio Internacional de HPV do Maranhão, II Workshop do Biobanco de Tumores e DNA do Maranhão, Brasil
Congress
 II Simpósio Internacional de HPV do Maranhão, II Workshop do Biobanco de Tumores e DNA do Maranhão, Brasil

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2015/07 Prevalence of high-risk human papilloma virus genotypes (HPV-16 and -18) in Angolan women with invasive cervical cancer: an early report
(Thesis) Arguer
 Ana Damasceno (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - Current Infeções sexualmente transmissíveis- HPV, Clamídia e Micoplasmas genitais Mestrado Integrado em Ciências Farmacêutica Universidade Fernando Pessoa Faculdade de Ciências da Saúde, Portugal
2013 - 2013 Deteção molecular do Papilomavírus humano Análises Clínicas e Saúde Pública Universidade Fernando Pessoa Faculdade de Ciências da Saúde, Portugal
2013 - 2013 Deteção molecular do Papilomavírus humano Mestrado Integrado em Ciências Farmacêuticas Universidade Fernando Pessoa Faculdade de Ciências da Saúde, Portugal