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Rita Macedo completed her PhD in Biology in 2019 at the Faculty of Sciences and Technology of the Universidade Nova de Lisboa. She received her Master's degree in Clinical Microbiology from the Faculty of Medicine of the University of Lisbon in 2007, and her Bachelor's degree in Chemistry from the Instituto Superior Técnico of the University of Lisbon in 2005. She is the head of the National Reference Laboratory for Mycobacteria at the Department of Infectious Diseases of the Instituto Nacional de Saúde Doutor Ricardo Jorge IP. Additionally, she is a member of the National Tuberculosis Program and a consultant in the field of laboratory diagnostics at the Direcção-Geral da Saúde (Directorate-General of Health, DGS), as well as the national Official Contact Point (OCP) for microbiology and tuberculosis epidemiology at the European Centre for Disease Prevention and Control (ECDC). Rita Macedo has published 47 articles in peer-reviewed journals, 2 book chapters, and numerous national guidelines and standards. She has participated in various scientific events as an organizer, speaker, and co-author of posters and oral communications. Currently, she is supervising two PhD students and a research fellow from the European Public Health Microbiology Programme (EUPHEM) of the ECDC, and has supervised over ten students (undergraduate, postgraduate, and specialization courses) throughout her professional career. She has participated as a researcher in seven funded scientific projects and is currently the PI of two public health projects funded by the DGS.
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Identification

Personal identification

Full name
Rita Macedo

Citation names

  • Macedo, Rita

Author identifiers

Ciência ID
341E-FB1E-DAFC
ORCID iD
0000-0003-2184-5136

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Infectious Diseases
Education
Degree Classification
2019
Concluded
 Biologia (Doutoramento)
Major in Genómica Molecular
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Tuberculosis: new era for diagnosis and surveillance using whole-genome sequencing-based approaches" (THESIS/DISSERTATION)
2007
Concluded
 Microbiologia Clínica (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2005
Concluded
 Química (Licenciatura)
Major in Bioquímica
Universidade de Lisboa Instituto Superior Técnico, Portugal
Affiliation

Positions / Appointments

Category
Host institution 		Employer
2020/01 - 2023/09 Board Member of DNCC (Disease Network Comittee Coordinator) European Centre for Disease Prevention and Control, Sweden

Others

Category
Host institution 		Employer
2019 - Current Member of the National Tuberculosis Programme Direcção-Geral da Saúde, Portugal
2012 - Current Head of the National Reference Laboratory for Mycobacteria Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2011 - Current National Official Contact Point (OCP) for Tuberculosis European Centre for Disease Prevention and Control, Sweden
2008 - Current Consultant (Tuberculosis) Direcção-Geral da Saúde, Portugal
Projects

Contract

Designation Funders
2024 - Current Perfil Genotípico da Tuberculose Prisional em Portugal
NA
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
 Direção Geral da Saúde
2023 - Current Protocolo para validação da metodologia GeneXPert no diagnóstico de tuberculose pulmonar na criança em amostras de fezes
NA
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
 Direção Geral da Saúde
Ongoing
2018 - 2022 Clinical significance of Mycobacterium tuberculosis cell wall structural diversity: contribution to novel mechanisms of antibiotic resistance and relevance towards tuberculosis progression and treatment
PTDC/BIA-MIC/31233/2017
Researcher
Concluded
2016 - 2020 Prevalência da aspergilose pulmonar crónica em doentes HIV+ com suspeita ou história prévia de tuberculose
-
Researcher
2016 - 2018 Evaluation of mycobacterial resistance acquisition to the antimicrobial peptide LLKKK18
-
Researcher
2014 - 2016 TBomics: AN OMICS APPROACH FOR DIAGNOSING TUBERCULOSIS
INDIGO-DBT2-062
Researcher
2010 - 2012 Epidemiologia molecular de Mycobacterium tuberculosis em Portugal: implementação e análise de uma base de dados
PTDC/SAL-ESA/71208/2006
Researcher

Other

Designation Funders
2017 - Current Identificação de genótipos associados a resistência e/ou multirresistência em Tuberculose usando nanopartículas de ouro
-
Researcher
2016 - 2018 Identificação, optimização e reposicionamento de compostos como potenciais medicamentos destinados ao tratamento de doenças infecciosas com expressão global
-
Researcher
Outputs

Publications

Book chapter
  1. Macedo, Rita. "Tuberculose". In Pneumologia fundamental. 2019.
    Published
  2. Macedo, Rita. "Clinical management of M/XDR-TB in the Northern Regional Reference Centre". In Compendium of good practices in the implementation of the Tuberculosis Action Plan for the WHO European Region 2016–2020. 2019.
    Published
Conference poster
  1. Sofia Carneiro; Miguel Pinto; Andrea Santos; Sónia Silva; João Paulo Gomes; Irene Rodrigues; Macedo, Rita. "Genomic diversity of Mycobacterium abscessus isolates in Portugal". Paper presented in 6th National Congress of Tropical Medicine, 2023.
  2. Joana Rodrigues; Sofia Carneiro; Macedo, Rita. Corresponding author: Macedo, Rita. "Genomic divesity and resistance profile of Mycobacterium avium strains circulating in Portugal over the last 5 years". Paper presented in 6th National Congress of Tropical Medicine, 2023.
  3. Sónia Silva; Sofia Carneiro; Irene Rodrigues; Andrea Santos; Macedo, Rita. Corresponding author: Macedo, Rita. "Subespécies do complexo Mycobacterium tuberculosis em circulação em Portugal". Paper presented in XII Congresso Nacional de Patologia Clinica, 2023.
  4. Andrea Santos; Délia Silva; Irene Rodrigues; Sónia Silva; Macedo, Rita. Corresponding author: Macedo, Rita. "Avaliação de nova metodologia de identificação e deteção de resistências de MycobacteriumTuberculosis". Paper presented in XII Congresso Nacional de Patologia Clinica, 2023.
  5. Olivença, Francisco; Nunes, Alexandra; Macedo, Rita; Pires, David; Silveiro, Cátia; ANES, ELSA; João Paulo Gomes; Catalão, Maria João. "Decoding Beta-lactam Susceptibility Patterns in Mycobacterium tuberculosis Clinical Strains". Paper presented in 32nd European Congress of Clinical Microbiology and Infectious Diseases, 2022.
  6. Miguel Pinto; Macedo, Rita. Corresponding author: Macedo, Rita. "Genome-scale epidemiological and antimicrobial resistance surveillance of Mycobacterium tuberculosis in Portugal". Paper presented in 42nd Annual Meeting of the European Society of Mycobacteriology, 2022.
  7. Andrea Santos; Miguel Pinto; João Munhá; Macedo, Rita. Corresponding author: Macedo, Rita. "Clinical, microbiologic and genomic characterization of a Mycobacteroides abscessus persistent infection – a case report". Paper presented in 42nd Annual Meeting of the European Society of Mycobacteriology, 2022.
  8. Andrea Santos; Sofia Carneiro; Sónia Silva; Anabela Silva; Macedo, Rita. Corresponding author: Macedo, Rita. "Trends in Circulation of Nontuberculous Mycobacteria in Portugal". Paper presented in 42nd Annual Meeting of the European Society of Mycobacteriology, 2022.
  9. Sofia Carneiro; Andrea Santos; Anabela Silva; João Paulo Gomes; Macedo, Rita. Corresponding author: Macedo, Rita. "Nontuberculous Mycobacteria diversity in Portugal: overview from the last 8 years". Paper presented in ECCMID, 2022.
  10. Olivença, Francisco; Alexandra Nunes; Macedo, Rita; David Pires; Silveiro, Cátia; Anes, Elsa; João Paulo Gomes; Maria João Catalão. "Repurposing Beta-lactams in Tuberculosis: a Valuable Therapeutic Alternative Against Drug-Resistant Clinical Isolates of Mycobacterium tuberculosis". Paper presented in NOVOS DESAFIOS EM SÁUDE NA ULISBOA, 2021.
  11. Francisco Olivença; David Pires; Alexandra Nunes; Elsa Anes; Macedo, Rita; João Paulo Gomes; Maria João Catalão; et al. "Inhibition of Peptidoglican Biosynthesis as a strategy against drug-resistant Mycobacterium tuberculosis". Paper presented in Symposium of Research on Tuberculosis and Nontuberculous Mycobacteria in Portugal, 2021.
  12. Francisco Olivença; David Pires; Alexandra Nunes; Macedo, Rita; Elsa Anes; João Paulo Gomes; Maria João Catalão. "Finding key genomic markers of beta-lactam susceptibility in clinical isolates of Mycobacterium tuberculosis.". 2021.
  13. Ricardo Cordeiro; Macedo, Rita; Natália André. "LTBI - MDR/XDR-TB cases - should all be treated?". Paper presented in ERS International Congress, 2021.
  14. Francisco Olivença; David Pires; Alexandra Nunes; Macedo, Rita; Elsa Anes; João Paulo Gomes; Maria João Catalão. "The combination of carbapnems and clavulanic acid efficiently inhibits Mycobacetrium tuberculosis clinical isolates". Paper presented in iMed.ULisboa Meeting, 2021.
  15. Ricardo Cordeiro; André Nunes; Carina Rolo; Natália André; Macedo, Rita; António Domingos. "An outbreak of extensively drug-resistant tuberculosis among a Portuguese family". Paper presented in ERS International Congress, 2020.
  16. Francisco Olivença; David Pires; Alexandra Nunes; Macedo, Rita; Elsa Anes; João Paulo Gomes; Maria João Catalão; et al. "Shifting the Paradigm: Repurposing beta-lactams antibiotics against drug-resistant clinical isolates of Mycobacterium tuberculosis.". Paper presented in The great Wall Symposium 2019, 2019.
  17. Macedo, Rita; Joana Isidro; Miguel Pinto; Alexandra Nunes; Vítor Borges; João Paulo Gomes. "Strengthening Mycobacterium tuberculosis surveillance through culture-independent whole-genome sequencing.". Paper presented in 12th International Meeting on Microbial Epidemiological Markers 2019, 2019.
  18. Olena Oliveira; Macedo, Rita; Margarida Correia-Neves; Raquel Duarte; Teresa Rito. "Multidrug-resistant tuberculosis in Portugal: 4-year nationwide molecular and epidemiological study.". Paper presented in 1º Simpósio de Investigação em Tuberculose e Micobactérias Não Tuberculosas em Portugal, 2018.
  19. Macedo, Rita; Alexandra Nunes; Sílvia Duarte; Luís Vieira; João Paulo Gomes. "Can we use bioinformatics platforms for predicting M. tuberculosis resistance?". Paper presented in 28th European Congress of Clinical Microbiology and Infectious Diseases, 2018.
  20. Inês João; Macedo, Rita. "Identificação de Micobactérias Não Tuberculosas: Estudo retrospetivos dos últimos 3 anos.". Paper presented in 11ª Jornadas de Doenças Infecciosas. Hospital Curry Cabral, 2018.
  21. Macedo, Rita; Inês João; Anabela Silva. "Caraterização laboratorial dos casos de tuberculose multirresistente diagnosticados entre 2012 e 2015 em Portugal". Paper presented in V Congresso Nacional de Saúde Pública, 2017.
  22. Bernardo Gomes; Macedo, Rita; Ana Maria Correia. "Surto de Tuberculose Multirresistente em Santa Maria da Feira". Paper presented in V Congresso Nacional de Saúde Pública, 2017.
  23. Catarina Pereira; Macedo, Rita; Carla Silva; João Perdigão; Isabel Portugal. "Molecular epidemiological perspective on the Mycobacterium tuberculosis population structure among immigrants in Lisbon, Portugal". Paper presented in 27th European Congress of Clinical Microbiology and Infectious Diseases, 2017.
  24. Pereira, Catarina Ventura; Macedo, Rita; Silva, Carla; Perdigão, João; Portugal, Isabel. "Insights on the population structure of Mycobacterium tuberculosis across the immigrant population in Lisbon, Portugal: implications at the Public Health level.". Paper presented in 8th iMed.ULisboa Postgraduate Students Meeting and 1st I3DU Meeting., 2016.
  25. Perdigão, João; Macedo, Rita; Machado, Diana; Silva, Carla; Jordão, Luísa; Couto, Isabel; Viveiros, Miguel; Portugal, Isabel. "Polymorphism in gidB gene as a genetic marker for the Mycobacterium tuberculosis Q1 cluster and implications for the streptomycin resistance level". Paper presented in MicroBiotec¿13, 2013.
  26. Perdigão, João; Silva, Hugo; Machado, Diana; Macedo, Rita; Maltez, Fernando; Silva, Carla; Jordão, Luísa; et al. "Genomic diversity of drug-resistant Mycobacterium tuberculosis isolates in Lisbon Portugal: towards tuberculosis genomic epidemiology.". Paper presented in MicroBiotec¿13, 2013.
  27. Perdigão, João; Macedo, Rita; Machado, Diana; Silva, Carla; Jordão, Luísa; Couto, Isabel; Viveiros, Miguel; Portugal, Isabel. "Correlation between streptomycin intermediate level resistance and gidB mutation in an endemic multidrug-resistant tuberculosis cluster.". Paper presented in 34th Annual Congress of the European Society of Mycobacteriology, 2013.
  28. Perdigão, João; Macedo, Rita; Silva, Carla; Portugal, Isabel. "Laboratory data on drug-resistant tuberculosis in Lisbon Health Region.". Paper presented in Tuberculosis 2012: Biology, pathogenesis, intervention strategies, 2012.
  29. Perdigão, João; Silva, Diogo; Pereira, Catarina; Macedo, Rita; Silva, Carla; Machado, Diana; Couto, Isabel; et al. "Dynamics and development of extensively drug-resistant tuberculosis, Portugal.". Paper presented in Tuberculosis 2012: Biology, pathogenesis, intervention strategies., 2012.
  30. Macedo, Rita; Irene Rodrigues; Arlinda Lopes; Edna Pereira. "Comparison of IGRA and TST for screening for LTBI in HIV positive patients". Paper presented in 33rd Annual Congress of the European Society of Mycobacteriology, 2012.
  31. Perdigão, João; Silva, Carla; Macedo, Rita; Brum, Laura; Portugal, Isabel. "Mutational analysis of eis gene in injectable second-line Mycobacterium tuberculosis drug-resistant strains". Paper presented in 32nd Annual Congress of the European Society of Mycobacteriology, 2011.
    10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1822
  32. Macedo, Rita; Rodrigues, Irene; Arlinda Lopes; Edna Pereira. "Tuberculosis in lisbon area: a laboratory data overview from 2008-2010". Paper presented in 32nd Annual Congress of the European Society of Mycobacteriology, 2011.
  33. Macedo, Rita; João Perdigão; Edna Pereira; Isabel Portugal. "Multidrug and Extensively Drug Resistant Tuberculosis in Lisbon Health Region in 2008-2010". Paper presented in 32nd Annual Congress of the European Society of Mycobacteriology, 2011.
  34. André Horta; Arlinda Lopes; Irene Rodrigues; Edna Pereira; Macedo, Rita. "Development of an in-house PCR for the detection of M. tuberculosis complex strains directly from clinical samples". Paper presented in 32nd Annual Congress of the European Society of Mycobacteriology, 2011.
  35. Lopes JS; Marques I; Soares P; Guimaraes H; Costa J; Miranda A; Alves A; et al. "SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity in Portugal and Northeast Brazil". Paper presented in XVIII International Congress for Tropical Medicine and Malaria, 2011.
  36. Perdigão, João; Macedo, Rita; Silva, Carla; Pinto, Claudia; Furtado, C; Brum, Laura; Portugal, Isabel. "Perspectiva Laboratorial da Tuberculose Resistente na Região de Saúde de Lisboa.". Paper presented in X & VIII Congresso Nacional de Doenças Infecciosas e Microbiologia Clínica & sobre SIDA., 2010.
  37. Perdigão, João; Macedo, Rita; Silva, Carla; Pinto, Claudia; Furtado, C; Brum, Laura; Portugal, Isabel. "Laboratory data report on drug-resistant tuberculosis in Lisbon Health Region between 2001-2006.". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010.
  38. Macedo, Rita; Irene Rodrigues; Arlinda Lopes; Edna Pereira. "Use of high-dose Isoniazid therapy for Isoniazid-resistant tuberculosis in Lisbon". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010.
  39. Macedo, Rita; Arlinda Lopes; Irene Rodrigues; Edna Pereira. "Evaluation of the MGIT TBcID for M. tuberculosis complex detection from liquid and solid cultures in a routine setting". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010.
  40. João Perdigão; Macedo, Rita; Laura Brum; Isabel Portugal. "Cluster differentiation by gyrA mutation analysis in extensive drug-resistant tuberculosis". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010.
  41. João Perdigão; Macedo, Rita; Laura Brum; Isabel Portugal. "Cluster association of gyrA mutations in extensively drug-resistant tuberculosis isolates from Lisbon, Portugal". Paper presented in European Congress of Clinical Microbiology and Infectious Diseases, 2010.
  42. Abecassis AB; Guimarães H; Miranda A; Marques I; Macedo, Rita; Antunes AF; Gonçalves CP; Leal JP; Gomes MG. "A countrywide database for tuberculosis research in Portugal". Paper presented in European Scientific Conference on Applied Infectious Disease Epidemiology, 2009.
  43. Carreira RJ; Macedo, Rita; Pereira E; Glez-Pena D; Reboiro-Jato M; Fdez-Riverola F; Diniz MS; Lodeiro C; Capelo JL. "Rapid Identification of Mycobacterium tuberculosis by peptide mass mapping with MALDI-TOF-MS". Paper presented in 1st International Congress on Analytical Proteomics (ICAP) and 5th Congress of the Portuguese Proteomics Network – ProCura, 2009.
  44. Reboiro-Jato M; Glez-Pena D; Carreira RJ; Macedo, Rita; Pereira E; Diniz MS; Santos HM; Lodeiro C; Capelo JL. "Bacterial Identification: a tool for rapid identification of Mycobacterium tuberculosis by peptide mass mapping". Paper presented in 1st International Congress on Analytical Proteomics (ICAP) and 5th Congress of the Portuguese Proteomics Network – ProCura, 2009.
  45. Glez-Pena D; Reboiro-Jato M; Fdez-Riverola F; Carreira RJ; Macedo, Rita; Pereira E; Diniz MS; et al. "BioMarker Search: a tool for biomarker discovery by protein quantification". Paper presented in 1st International Congress on Analytical Proteomics (ICAP) and 5th Congress of the Portuguese Proteomics Network – ProCura, 2009.
  46. da Silva G; Macedo, Rita; Famba I; Taniça M; Serrano R; MAluleque M; Agostinho A; et al. "Antimycobacterial activity of medicinal plants from Mozambique". Paper presented in 57th International Congress and Annual meeting of the Society for Medicinal Plant and Natural Product Research, 2009.
  47. António Amorim; Macedo, Rita; Edna Pereira. "Nontuberculous mycobacteria isolated from patients with lung disease from Lisboa e Vale do Tejo region during 2008". Paper presented in 30th Annual Congress of the European Society of Mycobacteriology, 2009.
  48. João Perdigão; Sabino A; Milho C; Macedo, Rita; Laura Brum; Isabel Portugal. "Characterization of gidB gene in Mycobacterium tuberculosis isolates in Lisbon Health region: role in streptomycin resistance and epidemiological markers". Paper presented in 30th Annual Congress of the European Society of Mycobacteriology, 2009.
  49. João Perdigão; Ferreira A; Malaquias A; Macedo, Rita; Laura Brum; Isabel Portugal. "Mutational analysis of genes associated with resistance to injectable second-line drugs in Mycobacterium tuberculosis clinical isolates from Lisbon, Portugal". Paper presented in 30th Annual Congress of the European Society of Mycobacteriology, 2009.
  50. João Perdigão; Sabino A; Milho C; Macedo, Rita; Laura Brum; Isabel Portugal. "Characterization of gidB gene in streptomycin-resistant Mycobacterium tuberculosis isolates in Lisbon Health region". Paper presented in 19th European Congress of Clinical Microbiology and Infectious Diseases, 2009.
  51. Perdigão J; Ferreira A; Malaquias A; Macedo, Rita; Brum L; Portugal I. "Mutations associated with resistance to second-line drugs in Mycobacterium tuberculosis clinical isolates from Lisbon, Portugal". Paper presented in 19th European Congress of Clinical Microbiology and Infectious Diseases, 2009.
  52. Macedo, Rita; Antonio Amorim; Edna Pereira. "Multidrug Resistant Tuberculosis: rapid molecular detection with MTBDrplus assay". Paper presented in 29th Annual Congress of the European Society of Mycobacteriology, 2008.
  53. Perdigão J; Sabino A; Milho C; Macedo, Rita; Brum L; Portugal I. "Characterization of gidB mutations in Streptomycin-resistant isolates in Lisbon, Portugal". Paper presented in 29th Annual Congress of the European Society of Mycobacteriology, 2008.
  54. Perdigão J; Macedo, Rita; Ribeiro A; Brum L; Portugal I. "Prevalence of embB306 mutations among ethambutol-resistant and susceptible isolates: correlation with ethambutol and multidrug resistance". Paper presented in 18th European Congress of Clinical Microbiology and Infectious Diseases, 2008.
  55. Perdigão J; Macedo, Rita; João I; Fernandes E; Ribeiro A; Brum L; Portugal I. "Multidrug and extensive drug-resistant tuberculosis in Lisbon, Portugal: molecular epidemiology and resistance mechanisms". Paper presented in 18th European Congress of Clinical Microbiology and Infectious Diseases, 2008.
  56. Perdigão J; Macedo, Rita; Brum L; Portugal I. "Mutations associated with streptomycin resistance in Mycobacterium tuberculosis: predominance and rapid detection in Lisbon, Portugal". Paper presented in Congresso Nacional MICRO-BIOTEC - XXXIII Jornadas Portuguesas de Genética, 2007.
  57. Perdigão J; Macedo, Rita; Brum L; Portugal I. "Occurrence of embB306 mutations in ethambutol-resistant and -susceptible Mycobacterium tuberculosis clinical isolates". Paper presented in Congresso Nacional MICRO-BIOTEC - XXXIII Jornadas Portuguesas de Genética, 2007.
  58. Furtado C; Macedo, Rita; Nogueira P; Antunes AF; Ferrinho P; Brum L. "Recent transmission of Tuberculosis in the Portuguese Health Region of Lisboa e Vale do Tejo in 2003". Paper presented in 4th Congress of the European Society for Emerging Infections, 2007.
  59. Furtado C; Macedo, Rita; Nogueira P; Antunes AF; Brum L; Ferrinho P. "Risk factors for Multidrug Resistant Tuberculosis (MDR-TB) in the Portuguese Health Region of Lisboa e Vale do Tejo in 2003". Paper presented in 4th Congress of the European Society for Emerging Infections, 2007.
  60. Furtado C; Macedo, Rita; Nogueira P; Antunes AF; Ferrinho P; Brum L. "Emergence of Extensively drug Resistant Tuberculosis (XDR-TB) in the Portuguese Health Region of Lisboa e Vale do Tejo in 2003". Paper presented in 4th Congress of the European Society for Emerging Infections, 2007.
  61. Nogueira P; Furtado C; Macedo, Rita; Antunes AF; Catarino J; Brum L; Ferrinho P. "Three sources capture-recapture analysis to assess the sensitivity of Tuberculosis surveillance in the Portuguese Health Region of Lisboa e Vale do Tejo in 2003". Paper presented in 4th Congress of the European Society for Emerging Infections, 2007.
  62. Perdigão J; Macedo, Rita; João I; Fernandes E; Brum L; Portugal I. "Multidrug-resistant Tuberculosis in Lisbon: molecular epidemiology and resistance". Paper presented in 4th Congress of the European Society for Emerging Infections, 2007.
  63. Macedo, Rita; Perdigão J; Portugal I; Brum L. "MDR-TB in Lisbon area: data report from 2004 to 2006". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007.
  64. Macedo, Rita; Perdigão J; Portugal I; Brum L. "XDR and MDR-TB markers: a way to overcome resistance detection". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007.
  65. Perdigão J; Macedo, Rita; Brum L; Portugal I. "Mutational characterization of ethambutol resistance-determining region in ethambutol-resistant isolates: prevalence of embB306 mutations and their role in ethambutol resistance". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007.
  66. Fernandes E; Reis L; Cristóvão P; Macedo, Rita; Garcia A; Varandas L; Brum L. "Miliary tuberculosis in a neonate". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007.
  67. Brum L; Macedo, Rita; Cristóvão P; Reis L; Fernandes E; Pereira E; Garcia A; Portugal I. "XDR tuberculosis in Lisbon health region". Paper presented in 17th European Congress of Clinical Microbiology and Infectious Diseases, 2007.
  68. Macedo, Rita; Fernandes E; Furtado C; Portugal I; Brum L. "Molecular epidemiology of Mycobacterium tuberculosis strains in Lisbon: Monitoring Family Lisboa". Paper presented in 12th International Congress of Infectious Diseases, 2006.
  69. Perdigão J; Macedo, Rita; João I; Fernandes E; Brum L; Portugal I. "Molecular characterization of multidrug resistant Mycobacterium tuberculosis strais isolated in Lisbon". Paper presented in 12th International Congress of Infectious Diseases, 2006.
  70. Macedo, Rita; Furtado C; Fernandes E; Portugal I; Brum L; VigLab Tuberculose Network. "Molecular epidemiology of Mycobacterium tuberculosis complex strains isolated in Lisbon area in 2003". Paper presented in Dia do Jovem Investigador, INSA, 2006.
  71. João I; Macedo, Rita; Fernandes E; Portugal I; Brum L; Perdigão J. "Screening and characterization of mutations in Isoniazid-resistant M. tuberculosis isolates from Lisbon". Paper presented in Dia do Jovem Investigador, INSA, 2006.
  72. Oramas E; Macedo, Rita; Brum L. "Mutational Analysis by DHPLC of multirresistant Mycobacterium tuberculosis strains". Paper presented in Dia do Jovem Investigador, INSA, 2006.
  73. Portugal I; Macedo, Rita; Fernandes E; Perdigão J; Joao I; Pereira E; Brum L. "Multidrug-resistant tuberculosis in Lisbon in 2003". Paper presented in 16th European Congress of Clinical Microbiology and Infectious Diseases, 2006.
  74. Oramas E; Macedo, Rita; Brum L. "Análise mutacional por DHPLC de estirpes de Mycobacterium tuberculosis multirresistentes". Paper presented in VI Jornadas de Análises Clínicas e Saúde Pública, 2006.
  75. Macedo, Rita; Fernandes E; Furtado C; Brum L. "Epidemiologia molecular de estirpes de Mycobacterium tuberculosis em Lisboa, 2003". Paper presented in V Jornadas de Actualização em Doenças Infecciosas, 2006.
  76. Macedo, Rita; Fernandes E; Portugal I; Brum L. "MIRU-VNTR and RFLP-IS6110 typing of Mycobacterium tuberculosis strains". Paper presented in 26th Annual Congress of the European Society of Mycobacteriology, 2005.
  77. Fernandes E; Macedo, Rita; Portugal I; Brum L. "Comparison of RFLP-IS6110 and MIRU-VNTR typing of Mycobacterium tuberculosis strains". Paper presented in 15th European Congress of Clinical Microbiology and Infectious Diseases, 2005.
Journal article
  1. Joana Rodrigues; Sofia Carneiro; Macedo, Rita. "Diversidade genómica e perfil de resistência dos isolados clínicos de Mycobacterium avium circulantes em Portugal entre 2018 e 2022". Anais do IHMT 22 2 (2024): 22-32. https://anaisihmt.com/index.php/ihmt/article/view/453.
    Open access • Published
  2. S. Sousa; C.M. Alves; R. Macedo; C. Carvalho; G. Gonçalves; R. Duarte. "An investigation of TB infection and reinfection among stone quarry workers". Pulmonology (2023): https://doi.org/10.1016/j.pulmoe.2023.05.004.
    10.1016/j.pulmoe.2023.05.004
  3. Sofia Carneiro; Miguel Pinto; Sónia Silva; Andrea Santos; Irene Rodrigues; Daniela Santos; Sílvia Duarte; et al. "Genome-Scale Characterization of Mycobacterium abscessus Complex Isolates from Portugal". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms242015402.
    10.3390/ijms242015402
  4. Andrea Santos; Miguel Pinto; Sofia Carneiro; Sónia Silva; Irene Rodrigues; João Munhá; João Paulo Gomes; Rita Macedo. "Microevolution of a Mycobacteroides abscessus subsp. bolletii strain in a clinical persistent infection". Infection, Genetics and Evolution 112 (2023): 105437-105437. https://doi.org/10.1016%2Fj.meegid.2023.105437.
    10.1016/j.meegid.2023.105437
  5. S. Sousa; R. Macedo; C.M. Alves; C. Carvalho; G. Gonçalves; R. Duarte. "Coffee shops, a hub for TB clusters?". Pulmonology (2023): https://doi.org/10.1016%2Fj.pulmoe.2023.04.007.
    10.1016/j.pulmoe.2023.04.007
  6. Rita Macedo; Joana Isidro; Rita Ferreira; Miguel Pinto; Vítor Borges; Sílvia Duarte; Luís Vieira; João Paulo Gomes. "Molecular Capture of Mycobacterium tuberculosis Genomes Directly from Clinical Samples: A Potential Backup Approach for Epidemiological and Drug Susceptibility Inferences". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032912.
    10.3390/ijms24032912
  7. Sofia Carneiro; João Paulo Gomes; Macedo, Rita. "Nontuberculous Mycobacteria: A Review". Clinical Infectious Diseases: Open Access 7 3 (2023): 206.
    Open access • Published
  8. Richard Anthony; E. Tagliani; V. Nikolayevskyy; R. de Zwaan; A. Mulder; M. Kamst; C. Ködmön; et al. "Experiences from 4 Years of Organization of an External Quality Assessment for Mycobacterium tuberculosis Whole-Genome Sequencing in the European Union/European Economic Area". Microbiology Spectrum (2022): http://dx.doi.org/10.1128/spectrum.02244-22.
    10.1128/spectrum.02244-22
  9. "SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal". Communications Medicine 2 1 (2022): http://dx.doi.org/10.1038/s43856-022-00072-0.
    10.1038/s43856-022-00072-0
  10. Rita Macedo; Ana Fernandes; Luís Gafeira Gonçalves; Maria Bento; Sandra I. Anjo; Bruno Manadas; Clara Barroso; et al. "Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples for Discovery and Validation of Tuberculosis Diagnostic Biomarker Signature". International Journal of Molecular Sciences 23 22 (2022): 13733-13733. http://dx.doi.org/10.3390/ijms232213733.
    10.3390/ijms232213733
  11. Francisco Olivença; Alexandra Nunes; Rita Macedo; David Pires; Cátia Silveiro; Elsa Anes; Maria Miragaia; et al. "Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing". Microbiology Spectrum (2022): https://doi.org/10.1128/spectrum.00674-22.
    10.1128/spectrum.00674-22
  12. Conde, R.; Laires, R.; Gonçalves, L.G.; Rizvi, A.; Barroso, C.; Villar, M.; Macedo, R.; et al. "Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort". Biomedical Journal 45 4 (2022): 654-664. http://dx.doi.org/10.1016/j.bj.2021.07.006.
    10.1016/j.bj.2021.07.006
  13. A. Santos; S. Carneiro; A. Silva; J.P. Gomes; R. Macedo. "Nontuberculous Mycobacteria in Portugal: Trends from the last decade". Pulmonology (2022): https://doi.org/10.1016/j.pulmoe.2022.01.011.
    10.1016/j.pulmoe.2022.01.011
  14. Macedo, Rita. "Impact of COVID-19 pandemic on tuberculosis laboratory services in Europe". European Respiratory Journal (2020): 2003890-2003890. http://dx.doi.org/10.1183/13993003.03890-2020.
    10.1183/13993003.03890-2020
  15. Rita Macedo; Joana Isidro; Maria Conceição Gomes; Ana Botelho; Teresa Albuquerque; Arlete Sogorb; Rui Bernardino; et al. "Animal-to-human transmission of Mycobacterium pinnipedii". European Respiratory Journal (2020): https://doi.org/10.1183/13993003.00371-2020.
    10.1183/13993003.00371-2020
  16. Macedo, Rita. "Use of a Whole Genome Sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017–2019: an ECDC pilot study". European Respiratory Journal (2020): 2002272-2002272. http://dx.doi.org/10.1183/13993003.02272-2020.
    10.1183/13993003.02272-2020
  17. Gomes B; Molina-Correa G; Neves-Reina L; Oliveira AC; Macedo R; Carvalho C; Correia AM. "Poly-resistant tuberculosis outbreak in Northern Portugal: a nine year tale.". Pulmonology (2020): http://europepmc.org/abstract/med/32238328.
    10.1016/j.pulmoe.2020.02.006
  18. Macedo, Rita. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal". Emerging Microbes & Infections (2020): http://dx.doi.org/10.1080/22221751.2020.1844552.
    10.1080/22221751.2020.1844552
  19. Equipas de resposta à emergência do diagnóstico laboratorial da COVID-19 no INSA. "O INSA e a resposta de emergência ao diagnóstico laboratorial da COVID-19 em Portugal". Boletim Epidemiológico Observações 9 12 (2020): 9-18.
    Published
  20. Macedo, Rita. "National advisory services for multidrug-resistant tuberculosis (MDRTB) in Europe: an ERS-TBnet survey". Tuberculosis (2019): http://dx.doi.org/10.1183/13993003.congress-2019.pa5285.
    10.1183/13993003.congress-2019.pa5285
  21. Rita Macedo; Miguel Pinto; Vítor Borges; Alexandra Nunes; Olena Oliveira; Isabel Portugal; Raquel Duarte; João Paulo Gomes. "Evaluation of a gene-by-gene approach for prospective whole-genome sequencing-based surveillance of multidrug resistant Mycobacterium tuberculosis". Tuberculosis 115 (2019): 81-88. https://doi.org/10.1016/j.tube.2019.02.006.
    10.1016/j.tube.2019.02.006
  22. Catarina Pereira; Pedro Gomes; Ricardo Taveira; Carla Silva; Fernando Maltez; Rita Macedo; Catarina Costa; et al. "Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in greater Lisbon, Portugal: Implications at the public health level". Infection, Genetics and Evolution (2019): https://doi.org/10.1016%2Fj.meegid.2019.03.025.
    10.1016/j.meegid.2019.03.025
  23. Rita Macedo; Raquel Duarte. "Trends of multidrug-resistant tuberculosis clustering in Portugal". ERJ Open Research 5 1 (2019): 00151-2018. https://doi.org/10.1183/23120541.00151-2018.
    10.1183/23120541.00151-2018
  24. Durão V; Silva A; Macedo R; Durão P; Santos-Silva A; Duarte R. "Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines.". Pulmonology (2018): http://europepmc.org/abstract/med/30309821.
    10.1016/j.pulmoe.2018.09.001
  25. Rita Macedo; Alexandra Nunes; Isabel Portugal; Sílvia Duarte; Luís Vieira; João Paulo Gomes. "Dissecting whole-genome sequencing-based online tools for predicting resistance in Mycobacterium tuberculosis : can we use them for clinical decision guidance?". Tuberculosis 110 (2018): 44-51. https://doi.org/10.1016/j.tube.2018.03.009.
    10.1016/j.tube.2018.03.009
  26. Perdigão J; Silva C; Diniz J; Pereira C; Machado D; Ramos J; Silva H; et al. "Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries.". Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2018): http://europepmc.org/abstract/med/29559379.
    10.1016/j.meegid.2018.03.011
  27. Macedo, Rita; Miguel Pinto; Vítor Borges; Alexandra Nunes; Joana Isidro; Sílvia Duarte; Luís Vieira; João Paulo Gomes. Corresponding author: Macedo, Rita. "Nova era na vigilância da tuberculose multirresistente em Portugal: sequenciação do genoma completo". Boletim Epidemiológico Observações 10 (2018): 17-21. https://repositorio.insa.pt/bitstream/10400.18/5693/1/Boletim_Epidemiologico_Observacoes_NEspecia10-2018_artigo4.pdf.
    Published
  28. van Leth F; Günther G; Hoffmann H; Lange C; European MDR-TB Database Collaboration. "Reply: Benefit of the Shorter Multidrug-Resistant Tuberculosis Treatment Regimen in California and Modified Eligibility Criteria.". American Journal of Respiratory and Critical Care Medicine (2017): http://europepmc.org/abstract/med/28715229.
    10.1164/rccm.201705-0995le
  29. Mendes-Bastos P; Macedo R; Duarte R. "Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?". The British journal of dermatology (2017): http://europepmc.org/abstract/med/28718933.
    10.1111/bjd.15500
  30. Olena Oliveira; A. Gaio; Anabela Silva; Rita Macedo; Raquel Duarte. "Shifting Profile of MDR-TB Patients in Northern Portugal?". International Journal of Clinical Research & Trials 2 1 (2017): https://doi.org/10.15344%2F2456-8007%2F2017%2F114.
    10.15344/2456-8007/2017/114
  31. Stucki D; Brites D; Jeljeli L; Coscolla M; Liu Q; Trauner A; Fenner L; et al. "Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.". Nature genetics (2016): http://europepmc.org/abstract/med/27798628.
    10.1038/ng.3704
  32. Lange C; Duarte R; Fréchet-Jachym M; Guenther G; Guglielmetti L; Olaru ID; Oliveira O; et al. "Limited Benefit of the New Shorter Multidrug-Resistant Tuberculosis Regimen in Europe.". American journal of respiratory and critical care medicine (2016): http://europepmc.org/abstract/med/27685538.
    10.1164/rccm.201606-1097le
  33. Perdigão J; Silva H; Machado D; Macedo R; Maltez F; Silva C; Jordao L; et al. "Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.". BMC genomics (2014): http://europepmc.org/abstract/med/25407810.
    10.1186/1471-2164-15-991
  34. Perdigão J; Macedo R; Machado D; Silva C; Jordão L; Couto I; Viveiros M; Portugal I. "GidB mutation as a phylogenetic marker for Q1 cluster Mycobacterium tuberculosis isolates and intermediate-level streptomycin resistance determinant in Lisbon, Portugal.". Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (2014): http://europepmc.org/abstract/med/24102832.
    10.1111/1469-0691.12392
  35. Botelho A; Perdigão J; Canto A; Albuquerque T; Leal N; Macedo R; Portugal I; Cunha MV. "Pre-multidrug-resistant Mycobacterium tuberculosis Beijing strain associated with disseminated tuberculosis in a pet dog.". Journal of clinical microbiology (2014): http://europepmc.org/abstract/med/24153119.
    10.1128/jcm.02800-13
  36. Hoefsloot W; van Ingen J; Andrejak C; Angeby K; Bauriaud R; Bemer P; Beylis N; et al. "The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study.". The European respiratory journal (2013): http://europepmc.org/abstract/med/23598956.
    10.1183/09031936.00149212
  37. Lopes JS; Marques I; Soares P; Nebenzahl-Guimaraes H; Costa J; Miranda A; Duarte R; et al. "SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil.". Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2013): http://europepmc.org/abstract/med/23648425.
    10.1016/j.meegid.2013.04.028
  38. Perdigão J; Macedo R; Silva C; Machado D; Couto I; Viveiros M; Jordao L; Portugal I. "From multidrug-resistant to extensively drug-resistant tuberculosis in Lisbon, Portugal: the stepwise mode of resistance acquisition.". The Journal of antimicrobial chemotherapy (2013): http://europepmc.org/abstract/med/23054995.
    10.1093/jac/dks371
  39. Macedo R; Antunes AF; Villar M; Portugal I. "Multidrug and extensively drug-resistant tuberculosis in Lisbon and Vale do Tejo, Portugal, from 2008 to 2010.". International journal of mycobacteriology (2012): http://europepmc.org/abstract/med/26787208.
    10.1016/j.ijmyco.2012.07.001
  40. Perdigão J; Macedo R; Silva C; Pinto C; Furtado C; Brum L; Portugal I. "Tuberculosis drug-resistance in Lisbon, Portugal: a 6-year overview.". Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (2011): http://europepmc.org/abstract/med/20731680.
    10.1111/j.1469-0691.2010.03351.x
  41. Amorim A; Macedo R; Lopes A; Rodrigues I; Pereira E. "Non-tuberculous mycobacteria in HIV-negative patients with pulmonary disease in Lisbon, Portugal.". Scandinavian journal of infectious diseases (2010): http://europepmc.org/abstract/med/20632900.
    10.3109/00365541003754485
  42. Perdigão J; Macedo R; Malaquias A; Ferreira A; Brum L; Portugal I. "Genetic analysis of extensively drug-resistant Mycobacterium tuberculosis strains in Lisbon, Portugal.". The Journal of antimicrobial chemotherapy (2010): http://europepmc.org/abstract/med/20028780.
    10.1093/jac/dkp452
  43. Perdigão J; Macedo R; Ribeiro A; Brum L; Portugal I. "Genetic characterisation of the ethambutol resistance-determining region in Mycobacterium tuberculosis: prevalence and significance of embB306 mutations.". International journal of antimicrobial agents (2009): http://europepmc.org/abstract/med/19097862.
    10.1016/j.ijantimicag.2008.09.021
  44. Macedo R; Amorim A; Pereira E. "Multidrug-resistant tuberculosis: rapid molecular detection with MTBDRplus assay in clinical samples.". Revista portuguesa de pneumologia (2009): http://europepmc.org/abstract/med/19401789.
    10.1016/s0873-2159(15)30140-9
  45. Perdigão J; Macedo R; João I; Fernandes E; Brum L; Portugal I. "Multidrug-resistant tuberculosis in Lisbon, Portugal: a molecular epidemiological perspective.". Microbial drug resistance (Larchmont, N.Y.) (2008): http://europepmc.org/abstract/med/18573039.
    10.1089/mdr.2008.0798
  46. Portugal I; Barreiro L; Vultos T; Macedo R; Furtado C; Fonseca Antunes A; Brum L. "Molecular epidemiology of Mycobacterium tuberculosis in Lisbon.". Revista portuguesa de pneumologia (2008): http://europepmc.org/abstract/med/18363021.
    10.1016/s0873-2159(15)30233-6
  47. Macedo, Rita; João Perdigão; Laura Brum; Isabel Portugal. Corresponding author: Macedo, Rita. "Tuberculose multirresistente em Lisboa". Revista Portuguesa de Pneumologia 13 (2007): 20-21.
    Published
Magazine article
  1. Macedo, Rita; Pinto, Miguel; Borges, Vitor; Nunes, Alexandra; Isidro, Joana; Duarte, Sílvia; Vieira, Luís; Gomes, JP. "New era on the surveillance of multidrug resistant tuberculosis in Portugal: whole genome sequencing", Boletim Epidemiológico Observações, 2018, http://repositorio.insa.pt/bitstream/10400.18/5693/1/Boletim_Epidemiologico_Observacoes_NEspecia10-2018_artigo4.pdf.
Newsletter article
  1. Macedo, Rita; Silva, Anabela ; Irene Rodrigues; Maria João Simões; Inês João; Anabela Silva. "Tuberculose em Portugal no período 2008-2012: avaliação da taxa de confirmação laboratorial no INSA e padrão de suscetibilidade aos antibacilares", Boletim Epidemiológico Observações, 2013, http://www2.insa.pt/sites/INSA/Portugues/PublicacoesRepositorio/Documents/observacoesN62013_artigo7.pdf.
Report
  1. Macedo, Rita. Corresponding author: Macedo, Rita. 2023. Vigilância Laboratorial da Tuberculose - Relatório 2020-2022.

Other

Other output
  1. Tuberculosis across the seas: CPLP-TB - a joint effort in cataloguing mycobacterium tuberculosis genetic diversity in the lusophone space. The Community of Portuguese Language Speaking Countries (CPLP) comprises nine countries across four continents, accounting for 7.2% of the world¿s land area, and where tuberculosis (TB) is still a cause of public health concern. A marked variation in TB incidence (23 to 551 cases per 100 000 habitants) can be observed across the different member-states and, despite of this, a considerable gap in t. 2017. Perdigão, João; Silva, Carla; Diniz, Jaciara; Pereira, Catarina; Machado, Diana; Ramos, Jorge; da Silva, Fernanda; et al. http://hdl.handle.net/10400.18/4737.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021 Inhibition of Peptidoglican Biosynthesis as a strategy against drug-resistant Mycobacterium tuberculosis II Symposium of Research on Tuberculosis and Nontuberculous Mycobacteria in Portugal
. Faculdade de Farmácia, Universidade de Lisboa (Portugal)
2017 Omics approaches towards discovery of biomarkers for early diagnosis of tuberculosis EMBL Symposium: From Single- to Multiomics: Applications and Challenges in Data Integration
EMBO (Germany)
2017 A metabolomics approach towards the early diagnostics of tuberculosis 4.º Congresso Nacional de Medicina Tropical (CNMT) e do 1.º Encontro Lusófono de Sida, Tuberculose e Doenças Oportunistas
IHMT (Portugal)
2017 Tuberculosis Across the Seas: CPLP-TB - A Joint Effort in Cataloguing Mycobacterium tuberculosis Genetic Diversity in the Lusophone Space 4.º Congresso Nacional de Medicina Tropical (CNMT) e do 1.º Encontro Lusófono de Sida, Tuberculose e Doenças Oportunistas
IHMT (Portugal)
2011 Six-year laboratory data report on drug-resistant tuberculosis in Lisbon Health Region, Portugal 21st ECCMID/ 27th ICC 2011
ECCMID (Italy)
2008 Assessing the sensitivity of tuberculosis surveilance and missing positive cases of Mycobacterium tuberculosis cultures in the Health Region of Lisboa e Vale do Tejo in 2003 using three sources capture-recapture analysis EUPHA
(Portugal)
2007 Mutational characterization of tlyA gene in capreomycin-resistant Mycobacterium tuberculosis clinical isolates 29th Annual Congress of the European Society of Mycobacteriology
(Bulgaria)
2007 Genetic characterization of Multidrug Resistant and Extensively Drug Resistant Tuberculosis in Lisboa e Vale do Tejo Health region Congresso Nacional MICRO-BIOTEC - XXXIII Jornadas Portuguesas de Genética
(Portugal)
2007 Tuberculose Multirresistente em Lisboa XXIII Congresso de Pneumologia
(Portugal)
2007 Genetic characterization of multidrug resistant tuberculosis isolates in Lisbon in 2003 28th Annual Congress of the European Society of Mycobacteriology
(Greece)
2007 Casuística Laboratorial das micobactérias atípicas identificadas no Insa V Encontro Nacional das Ciências e Tecnologias da Saúde
(Portugal)
2006 Molecular characterization of Multidrug Resistant Mycobacterium tuberculosis strains isolated in Lisbon 12th International Congress of Infectious Diseases
(Portugal)
2006 Molecular typing of M. tuberculosis by mycobacterial interspersed repetitive units – variable number tandem repeat analysis in Lisbon in 2003 16th European Congress of Clinical Microbiology and Infectious Diseases
(France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Evaluation of Nanopore sequencing for Mycobacterium tuberculosis genotypic drug susceptibility prediction
Supervisor
 EUROPEAN PUBLIC HEALTH MICROBIOLOGY PROGRAMME (Specialization course)
European Centre for Disease Prevention and Control, Sweden
2021 - Current Genomics of nontuberculous mycobacteria (NTM): development of a laboratory tool for rapid and precise diagnosis and surveillance of NTM infections
Supervisor
 Biologia
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 - Current Nano-sensors for real-time bio-aerosol detection
Co-supervisor
 Advanced Integrated Microsystems (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/12 Diversidade genómica e perfil de resistência de isolados clínicos do complexo Mycobacterium avium circulantes em Portugal nos últimos 8 anos
Supervisor
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2023/10 - 2023/11 Diagnóstico laboratorial de tuberculose (molecular /fenotípico / genómico / vigilância)
Supervisor
 Especialização em Farmácia (Specialization course)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/06 - 2023/07 Diagnóstico laboratorial da tuberculose (molecular / fenotípico / genómico / vigilância)
Supervisor
 Especialização em Farmácia (Specialization course)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020 Development of methodologies to predict resistance of M. tuberculosis strains to Bedaquiline and Delamanid
Supervisor
 EUROPEAN PUBLIC HEALTH MICROBIOLOGY PROGRAMME (Specialization course)
European Centre for Disease Prevention and Control, Sweden
2016/04 - 2016/07 Padrão de susceptibilidade de M. tuberculosis aos antimicrobianos entre 2014 e 2015
Supervisor
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2016/01 - 2016/07 Identificação, optimização e reposicionamento de compostos como potenciais medicamentos destinados ao tratamento de doenças infecciosas com expressão global
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/01 - 2014/05 análise dos dados de epidemiologia convencional e molecular da tuberculose pulmonar, diagnosticada entre 2008 e 2013 em indivíduos residentes na área metropolitana de Lisboa, área com elevada incidência de TB, com vista a determinar a prevalência da co-infecção VIH/Tuberculose e factores de risco associados
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/07 - 2010/09 Desenvolvimento e implementação de uma tecnologia baseada em amplificação de ácidos nucleicos para detecção de Mycobacterium tuberculosis directamente na amostra clínica
Supervisor
 Biologia Marinha e Biotecnologia (Degree)
Escola Superior de Hotelaria e Turismo do Estoril, Portugal
2009/03 - 2009/03 Métodos moleculares de identificação de micobactérias e de mutações genéticas associadas a resistência a antibacilares e Testes de sensibilidade a antibióticos de 1ª e 2ª linha
Supervisor
 Estágio da Carreira de Técnicos Superiores de Saúde, ramo de laboratório (Specialization course)
2006/12 - 2007/06 Técnicas de identificação de espécies de Mycobacterium e Testes de sensibilidade a antibióticos de 1ª e 2ª linha
Supervisor
 Análises Clínicas e Saúde Pública (Degree)
Escola Superior de Saúde Ribeiro Sanches, Portugal
2005/08 - 2006/08 Desenvolvimento da tecnologia de D-HPLC para detecção de mutações associadas a resistência de Mycobacterium tuberculosis
Supervisor
 Análises Clínicas e de Saúde Pública (Degree)
Escola Superior de Tecnologias da Saúde de Coimbra, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/03 - 2022/03 Simpósio “Investigação em Tuberculose: que caminhos?” - no âmbitos das comemorações oficiais do Dia Mundial da Tuberculose (2022/03 - 2022/03)
Symposium (President of the Organising Committee)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2021/03 - 2021/03 Webinar “O papel do laboratório no diagnóstico da TB” - oragnização conjunta INSA e DGS no âmbito das comemorações do Dia Mundial da tuberculose (2021/03 - 2021/03)
Conference
 Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/10/27 - 2023/10/27 "Tuberculose, momento presente e desafios futuros" - palestra realizada sob convite no âmbito de um Workshop sobre diagnóstico in vitro organizado pela Isoder
Workshop
2023/10/20 - 2023/10/20 "Tuberculose em Portugal: Desafios no Controlo, Diagnóstico e Vigilância Laboratorial" - palestra realizada sob convite no âmbito da 2ª Jornada Iberoamericana - Sanidad sin fronteras
Symposium
 Sanidad sin fronteras
2023/10/17 - 2023/10/17 "Diagnóstico Laboratorial de Tuberculose: Estado da Arte em Portugal" - palestra sob convite no âmbito de uma sessão sobre Diagnóstico de Micobactérias
Workshop
Centro Hospitalar e Universitario de Coimbra EPE Campus dos Hospitais da Universidade de Coimbra, Portugal
2023/05/05 - 2023/05/05 "O papel do laboratório no diagnóstico de Tuberculose" - palestra realizada sob convite da Comissão de Trabalho para a Tuberculose da Sociedade Portuguesa de Pneumologia
Conference
 Fórum Primavera
Sociedade Portuguesa de Pneumologia, Portugal
2023/05/03 - 2023/05/04 "Passado, presente e Futuro do Diagnóstico de Tuberculose: Atualização no estudo das micobactérias - o papel do Laboratório de Referência" - palestra realizada sob convite da Quilaban no âmbito das comemorações dos seus 50 anos realizada em Lisboa e no Porto
Meeting
 Passado Presente e Futuro da Microbiologia
Quilaban, Portugal
2023/03/23 - 2023/03/23 "Inovação na abordagem da Tuberculose - o papel do laboratório" - palestra realizada sob convite da ARS Norte no âmbito do Encontro Regional da Tuberculose do Norte para o Dia Mundial da Tuberculose
Meeting
 Encontro Regional da Tuberculose do Norte
Administração Regional da Saúde - Norte, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/07/21 Past, present and future of drug-resistant tuberculosis treatment
(Thesis) Main arguer
 Mariana Ruiz Estrela (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/12 Ascertaining mycobacterial inducible resistance to peptidoglycan synthesis inhibitors
(Thesis) Main arguer
 Cláudia Sofia Oliveira Ferreira (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/04 Clinical significance of Mycobacterium tuberculosis cell wall structural diversity: contribution to novel mechanisms of antibiotic resistance and relevance towards tuberculosis progression and treatment
(Thesis) Main arguer
 Francisco Olivença (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/02/09 - 2024/02/09 "O que há de novo nos testes laboratoriais" - disciplina lecionada no âmbito de uma formação em Tuberculose para médicos e enfermeiros do Centros de Diagnóstico Pneumológico (CDP Tuberculose (Curso de Especialização Tecnológica) Direção Geral da Saúde, Portugal
2023/10 - 2023/11 Curso Diagnóstico Laboratorial de Tuberculose e micobacterioses (9ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2023/09/18 - 2023/09/22 Diagnóstico laboratorial de tuberculose (PALOPS) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2023/06/07 - 2023/06/07 "Métodos de diagnóstico de tuberculose activa: a articulação com o laboratório" - disciplina lecionada no âmbito de uma formação em Tuberculose para médicos e enfermeiros do Centros de Diagnóstico Pneumológico (CDP Tuberculose (Curso de Especialização Tecnológica) Direção Geral da Saúde, Portugal
2023/05/08 - 2023/05/12 Diagnóstico laboratorial de tuberculose (PALOPS) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2022/10/03 - 2022/10/31 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (8ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2022/04 - 2022/04 Diagnóstico laboratorial de tuberculose (PALOPS) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2021/11/04 - 2021/11/29 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (7ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2020/12/12 - 2020/12/13 "Tuberculose: o agente" - disciplina lecionada por convite da Sociedade Portuguesa de Pneumologia no âmbito da "Escola da Infeção" (Curso de Especialização Tecnológica) Sociedade Portuguesa de Pneumologia, Portugal
2020/10/12 - 2020/11/16 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (6ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2019/10/07 - 2019/11/11 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (5ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2018/10/22 - 2018/11/26 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (4ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2017/09/25 - 2017/10/30 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (3ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2016/10/03 - 2016/11/14 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (2ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2015/10/19 - 2015/12/09 Diagnóstico laboratorial de tuberculose e micobactérias (em b-learning) (1ª ed.) (Curso de Especialização Tecnológica) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal