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Carla Lima obtained his First Degree in Chemistry in 2020 and his Master’s Degree in chemistry at the Faculty of Sciences of the University of Porto (FCUP) in 2022. During his Master's Thesis, he performed his work in the Medicinal Chemistry Group of FCUP, under the supervision of Doctor Sofia Benfeito, entitled “Development of new multitarget-directed ligands with potential application in Alzheimer’s disease”. After the MSc completion, Carla became a research fellow in the same group and his work focused on the development of bona fide targeted covalent inhibitors to unravel NOX2 (2022-2023). Later in 2023, she was awarded a PhD Research Scholarship from Fundação para a Ciência e Tecnologia and she’s currently a PhD student in chemistry under the supervision of Doctor Sofia Benfeito. Carla’s research interests include neurodegenerative disease, Targeted Drug Delivery, and Medicinal Chemistry.
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Identification

Personal identification

Full name
Carla Patricia Costa Lima

Citation names

  • Lima, Carla

Author identifiers

Ciência ID
3514-AAA6-3E95
ORCID iD
0000-0001-9389-686X
Scopus Author Id
57206493270

Email addresses

  • up201705563@fc.up.pt (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2023/09/12 - 2027/09
Ongoing
 Doutoramento em química (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2020/09/28 - 2022/10
Concluded
 Química (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Development of new multitargetdirected ligands with potential application in Alzheimer's disease" (THESIS/DISSERTATION)
 16
2017/09/13 - 2020/09/29
Concluded
 Química (Licenciatura)
Major in Formação complementar Centrada em Química
Universidade do Porto Faculdade de Ciências, Portugal
"A importância das fluoroquinolonas como agentes antibacterianos" (THESIS/DISSERTATION)
 13
Affiliation

Others

Category
Host institution 		Employer
2023/09/12 - Current PhD Student Fellow Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2022/10/15 - 2023/07/31 Master Research Fellow (NOXIous Project - EXPL/BIA-BQM/0492/2021) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2022/10/15 - 2023/07/31 Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure
EXPL/BIA-BQM/0492/2021
Research Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2023/01 - Current DeFend: De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators
2022.04633.PTDC
PhD Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal
Outputs

Publications

Conference poster
  1. Carla Lima; Letícia Soares; Catarina Alves; Daniel Chamaria; Lisa Sequeira; Fernando Cagide; Fernanda Borges; Sofia Benfeito. "Getting around on Friedrich ataxia: development of new mitochondriotropic strategies". Paper presented in Ciência 2024: + Ciência para uma só saúde para o bem-estar global, 2024.
  2. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Recent Advances in the Discovery of Isoform-Selective NOX Inhibitors". Paper presented in Encontro Ciência 2024, 2024.
  3. Mariana Castelôa; Joana Reis; Carla Lima; Marta Massari; Sara Marchese; Lorenzo Basile; Fernanda Borges; et al. "Insights into the Development of Isoform-Selective, Non-Interfering Nox Inhibitors". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network Rome, Italy, 2024.
  4. Carla Lima; Catarina Alves; Lisa Sequeira; Fernando Cagide; Fernanda Borges; Sofia Benfeito. "De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network Rome, Italy, 2024.
  5. Soares, Letícia; Lima, Carla; Chavarria, Daniel; Lisa, Sequeira; Alves, Catarina; Borges, Fernanda; Benfeito, Sofia; et al. "Development of new iron chelators targeting mitochondria with potencial application in friedreich ataxia". Paper presented in IJUP - Encontro de Investigação Jovem, 2024.
  6. Castelôa, Mariana; Lima, Carla; Benfeito, S.; Brandon Aguiar; Soares Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the Reactivity and Drug-like Profile of Potential Covalent NOX2 Inhibitors". Paper presented in MedChem 2023 - XII Paul Ehrlich Euro-PhD Network meeting, 2023.
  7. Lima, Carla; Benfeito, Sofia ; Borges, Fernanda. "New Multitarget-directed ligands for the treatment of Alzheimer's disease". Paper presented in Mitochondrial physiology, redox biology, and genetics. International Meeting, May 12 and 13, 2023.
  8. Silva, Vera; Benfeito, Sofia; Lima, Carla; Chavarria, Daniel; Gonçalves, Tiago; Costa, Inês; Remião, Fernando; Borges, Fernanda; Silva, Renata. "3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson's disease". Paper presented in II TOXRUN International Congress 2023, 2023.
  9. Mariana Casteloa; Pedro Soares; Sofia Benfeito; Carla Lima; Fernanda Borges; Daniel Chavarria. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Encontro Galego Português de Química, 2022.
  10. Carla Lima; Fernanda Borges; Sofia Benfeito. "New Multitarget-directed ligands for the treatment of Alzheimer's disease". Paper presented in 1º Congresso de Ciências, 2022.
  11. Vera silva; Sofia Benfeito; Inês Costa; Carla Lima; Daniel Chavarria; Fernando Remião; Fernanda Borges; Renata Silva. "Evaluation of cytotoxic and neuroprotective profile of potential dual-acting ligands for the treatment of Parkinson's disease". Paper presented in MedChem 2022 - XI Paul Ehrlich Euro-PhD Network meeting, 2022.
Journal article
  1. Benfeito, Sofia; Albuquerque, Bárbara; Sequeira, Lisa; Lima, Carla; Chavarria, Daniel; Serrão, Paula; Cagide, Fernando; Soares-da-Silva, Patrício; Borges, Fernanda. "Discovery of a Potent, Selective, and Blood-Brain Barrier Permeable Non-nitrocatechol Inhibitor of Catechol-O-methyltransferase". Journal of Medicinal Chemistry (2024): http://dx.doi.org/10.1021/acs.jmedchem.4c01682.
    10.1021/acs.jmedchem.4c01682
  2. Chavarria, Daniel; Benfeito, Sofia; Soares, Pedro; Lima, Carla; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; et al. "Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor". European Journal of Medicinal Chemistry 243 (2022): 114740. http://dx.doi.org/10.1016/j.ejmech.2022.114740.
    10.1016/j.ejmech.2022.114740
Thesis / Dissertation
  1. "A importância das fluoroquinolonas como agentes antibacterianos". Degree, 2020.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/11/17 Development of new multitarget-directed ligands with potential application in Alzheimer's disease XXVI Encontro Galego-Português de Química
Faculdade de Química da Universidade de Santiago de Compostela (Santiago Compostela, Spain)
2022/05/05 Development of new multitarget-directed ligands with potential application in Alzheimer's disease IJUP’22 – 15º Encontro de Investigação Jovem da Universidade do Porto
Universidade do Porto (Porto, Portugal)
2022/04/27 Development of new multitarget-directed ligands with potential application in Alzheimer's disease Seminário Cientifico do Mestrado de Química
Faculdade de Ciências da Universidade do Porto (Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06/26 - 2023/07/12 Co-organizer/Trainer of the international course "Drug Discovery 2030: A Roadmap for a New Decade". This course aimed to improve, via virtual classes and a week of intensive training, the participants skills in Medicinal Chemistry and Chemistry Biology. This course was funded with support from the European Commission and implemented within the framework of Blended Intensive Programmes (BIPs), a new format of Erasmus+ mobility. https://drugdiscovery2030.pt/ (2023/06/26 - 2023/07/12) (2023/06/26 - 2023/07/12) Erasmus Plus, Netherlands

Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal

Università degli Studi di Cagliari, Italy

Università degli Studi di Pisa, Italy

Universiteit Gent Faculteit Farmaceutische Wetenschappen, Belgium

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/04/21 - 2022/04/24 Demonstração do curso de química pela Faculdade de Ciências da Universidade do Porto no pavilhão multiusos de Gondomar
Exhibition
 Mostra da UP 19º
Universidade do Porto, Portugal
2018/04/12 - 2018/04/15 Demonstração do curso de química pela Faculdade de Ciências da Universidade do Porto nas instalações ICBAS/FFUP
Exhibition
 Mostra da UP 16º
Universidade do Porto, Portugal
2018/02/22 - 2018/02/23 Demostração de várias atividade na Faculdade de Ciências da Universidade do Porto
Exhibition
 Dias Abertos FCUP 2018
Universidade do Porto Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2022 - Current Centro de Investigação em Química da Universidade do Porto