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Ana Luísa Carvalho, Ph.D., completed her doctoral studies in Structural Biology in 2002 and has since served as a Senior Independent Researcher at UCIBIO-NOVA, a position she began in 2003. Her research endeavors are dedicated to uncovering unexplored biological protein-carbohydrate interactions with significant biotechnological implications in nutrition, pharmaceuticals, and the biofuel industry. Leveraging a diverse array of structural biology and biophysics methods, Ana Luísa employs cutting-edge techniques, notably X-ray Crystallography, to elucidate molecular mechanisms. ------- > In her quest for advancing structural biology techniques, Ana Luísa is currently spearheading the implementation of Cryo-Electron Microscopy methods at UCIBIO. In this capacity, she leads the NOVA FCT node of the CryoEM-PT National Roadmap Infrastructure, facilitating groundbreaking research initiatives. ------- > Ana Luísa's commitment to mentorship and academic leadership is evident through her supervision of five successful Ph.D. students, one of whom was honored with the Antonio Xavier Prize for Best Thesis in 2013. Presently, she mentors a Ph.D. student from the Biochemistry NOVA FCT Doctoral program, in addition to training MSc students, Post-Doctoral Fellows, and other undergraduate and graduate students. ------- > Having served as an Invited Assistant Professor at NOVA FCT from 2003 to 2008 and as a member of the Scientific Council from 2012 to 2015, Ana Luísa has played pivotal roles in academic governance and curriculum development. ------- > As Principal Investigator, Ana Luísa has steered four national FCT-MCTES funded projects and contributed as a team member in 15 others. She presently co-leads the FCT-MCTES GlycOSELECT project, securing a total of 981,673.00 EUR in R&D Projects under her leadership. Her contributions have been recognized through prestigious awards, including the Santander-Totta Scientific Merit Award (2012), the Bluepharma Innovation Award (2013), and the Gilead Genese Award (2022). ------- > Ana Luísa's prolific research output encompasses 58 peer-reviewed publications (14 as corresponding author), 6 book chapters (one in press), 22 invited oral communications, and 30 co-authored oral communications. Additionally, she has co-authored 95 poster presentations, with nine awarded as Best Poster. Her editorial contributions include serving as a Guest Editor for a Special Issue of the open-access journal Crystals. Citation metrics in Scopus indicate 65 documents with citation data, with more than 1680 citations and an h-index of 22. ------- > Engaging in science outreach activities, Ana Luísa has actively contributed to the International Year of Crystallography (2014) and the International Year of Chemistry (2011). She has also served as a regular translator for the Science-in-School magazine (2006-2012) and maintains active engagement through social media platforms and her personal website. Since January 2020, Ana Luísa has undertaken the role of Ambassador for Science Communication & Outreach for the XTAL research lab.
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Identification

Personal identification

Full name
Ana Luisa Moreira de Carvalho
Date of birth
1972/08/07

Citation names

  • Carvalho, Ana Luísa
  • Carvalho, Ana L.
  • Carvalho, AL

Author identifiers

Ciência ID
351C-DCB9-6912
ORCID iD
0000-0002-3824-0240
Google Scholar ID
IQgJcAAAAJ
Researcher Id
G-5638-2011
Scopus Author Id
57195976906

Email addresses

  • almc@fct.unl.pt (Professional)

Addresses

  • UCIBIO, Departamento de Quimica, FCT-NOVA, 2829-516, Caparica, Almada, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemical Research Methods

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Elementary (A2) Advanced (C1) Intermediate (B1) Intermediate (B1) Beginner (A1)
Spanish; Castilian Upper intermediate (B2) Proficiency (C2) Intermediate (B1) Proficiency (C2) Beginner (A1)
Education
Degree Classification
2002/12/01 - 2003/11/14
Concluded
 Structural characterization of cellulosomal protein complexes: study of function and assembly mechanisms (Pós-doutoramento)
Major in Structural Biology
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade Nova de Lisboa, Portugal
1998/02/01 - 2002/11/05
Concluded
 Biochemistry (Doutoramento)
Major in Structural Biology
Universidade Nova de Lisboa, Portugal

Centro de Investigaciones Biológicas, Spain
"Caracterização Estrutural e Bioquímica de uma Protease de Serina (Calicreína) Isolada do Plasma Seminal de Cavalo." (THESIS/DISSERTATION)
 Approved by unanimity
1996/09/01 - 1998/01/31
Concluded
 MSc in Biophysics and Biomedical Enginneering (Mestrado)
Major in Biophysics
Universidade de Lisboa Instituto de Biofísica e Engenharia Biomédica, Portugal
"aSFP, an acidic Seminal Fluid Protein: crystallization, heavy-atom derivatization and X-ray diffraction data collection" (THESIS/DISSERTATION)
 A, Very Good
1989/09/01 - 1992/06/01
Concluded
 Degree of Proficiency in English (Diploma de especialização)
British Council Lisbon, Portugal
 Grade C
Affiliation

Science

Category
Host institution 		Employer
2003/10 - Current Auxiliary Researcher (Research) Unidade de Ciências Biomoleculares Aplicadas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
(...)
2002 - 2003 Postdoc (Research) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2000/03 - 2000/04 Research Trainee (Research) Centro de Investigaciones Biológicas, Spain
2000 - 2000 Research Trainee (Research) Instituto de Biomedicina de Valencia, Spain
1999/06 - 1999/07 Research Trainee (Research) Max-Planck-Institut für Biochemie, Germany
1998/11 - 1998/12 Research Trainee (Research) Max-Planck-Institut für Biochemie, Germany
1998/03 - 1998/03 Research Trainee (Research) Centro de Investigaciones Biológicas, Spain
1994/08 - 1994/12 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2003/11/01 - 2007/02/28 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Contract

Designation Funders
2023/01/01 - 2027/12/31 CryoEM@NOVA: a cryo electron microscopy hub enabling drug discovery
101087571
Primary Coordinator Contact
Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Horizon 2020
Ongoing
2023/03/01 - 2026/02/28 Glycofoldamers as bacterial toxin inhibitors
2022.03561.PTDC
10.54499/2022.03561.PTDC
Universidade NOVA de Lisboa, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2026 GlycOSELECT: Targeting a toolbox of microbiome O-Glycan-Selective proteins towards new approaches in cancer research
2022.06104.PTDC
Co-Principal Investigator (Co-PI)
Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/12/01 - 2025/11/30 GLYCOTwinning: Building Networks to Excel in Glycosciences
101079417
member of team
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Horizon 2020
Ongoing
2023/03/12 - 2024/09/11 Designing a new generation of antibody-enzyme conjugates for cancer immunotherapy through glycocalyx editing in feline mammary carcinoma
2022.07903.PTDC
10.54499/2022.07903.PTDC
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2021/07/01 - 2023/06/30 LISBOA-01-0247-FEDER-047033 - GlycoMed: A new generation of enzymes for biofilm dispersion and immunomodulation in cancer
LISBOA-01-0247-FEDER-047033
Researcher
NZYTech Lda, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2022/09/30 Detoxification of Hydrogen Peroxide by Pathogenic Bacteria - E.coli Tri-haem peroxidase as a model
PTDC/BIA-BQM/29442/2017
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2021 GLYCOInteract: Glycan-human microbiome interaction: glycan diversity and recognition in the human gut with impact on health and nutrition
PTDC/BIA-MIB/31730/2017
Researcher
Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2021 Characterization of reflectin proteins and reflectin-materials
PTDC/BII-BIO/28878/2017
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2021 Destoxificação de peróxido de hidrogénio por Bactérias Patogénicas - Peroxidase tri-hémicas de E.coli como modelo
PTDC/BBB-BQB/29442/2017
Researcher
Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/12/31 Determinantes moleculares de diversidade bacteriana de celulossomas em nichos ecológicos diferentes
PTDC/BIA-MIC/5947/2014
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/01 - 2019/05/01 An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition
Provided by PTCRIS: 139494
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2016/04/01 - 2019/04/01 Regulação farmacológica das proteínas da família p53: a caminho de novas terapias anticancerígenas
PTDC/DTP-FTO/1981/2014
Universidade do Minho, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/01 - 2018/12 Molecular determinants of bacterial cellulosome diversity in different ecological niches
Provided by PTCRIS: 144587
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2015/12 - 2018/11 Targeting p53 family proteins: on the route to new anticancer agents
Provided by PTCRIS: 140607
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2013/07 - 2016/06 Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography
125363
Provided by PTCRIS: 125363
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2013/04 - 2015/04 Ionic liquid-based systems for protein crystallization
129159
Provided by PTCRIS: 129159
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2013/07/01 - 2014/12/31 Desenvolvimento de microarrays de coesina para a determinação de especificidades coesina-doquerina de novas espécies cellulolíticas
EXPL/BBB-BEP/0506/2012
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 Microarrays de hidratos de carbono para identificação de novos ligandos no reconhecimento de polissacáridos por módulos proteicos de bactérias.
PTDC/QUI-QUI/112537/2009
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03 - 2014/08 A carbohydrate microarray platform for discovery of ligands in polysaccharides recognised by microbial carbohydrate-binding modules.
Provided by PTCRIS: 112537
112537
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2013/07 - 2014/06 Development of cohesin- microarrays for determining cohesin-dockerin specificities of novel cellulolytic species
Provided by PTCRIS: 126085
126085
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2010/01/01 - 2013/06/30 Estrutura, função e mecanismos de acção de novas Glicosido Hidrolases e Módulos de Ligação a Carbohidratos do celulossoma do Clostridium thermocellum
PTDC/BIA-PRO/103980/2008
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 O Celulossoma: estrutura, função e especificidade de novas celulases e complexos supra-moleculares
PTDC/QUI-BIQ/100359/2008
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Centro de Investigaciones Biológicas Margarita Salas, Spain

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Consejo Superior de Investigaciones Científicas, Spain
Fundação para a Ciência e a Tecnologia
Concluded
2010/01 - 2013/06 The Cellulosome assembly: structure, function and specificity of new cellulases and supramolecular complexes
Provided by PTCRIS: 100359
100359
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2011/01/01 - 2012/12/31 Strategic Project - LA 6 - 2011-2012
PEst-C/EQB/LA0006/2011
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/03 - 2012/03 Molecular Determinants of Ligand Specificity in Carbohydrate-Binding Modules: an NMR and X-ray crystallography integrated study
SFRH/BD/35992/2007
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2011/12/31 Estrutura e função de novos módulos de ligação a carbohidratos e complexos coesina-doquerina do Clostridium thermocellum
PTDC/BIA-PRO/69732/2006
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01 - 2011/12 Structure and function of novel carbohydrate-binding modules and cohesin-dockerin protein complexes from Clostridium thermocellum
69732
Provided by PTCRIS: 69732
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2008/01 - 2011/09 A combined approach of X-ray Crystallography, NMR and Computational Chemistry for the study of the molecular interactions that define the ligand specificity in cellulosomal Carbohydrate Binding Modules
68286
Provided by PTCRIS: 68286
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
2008 - 2010 Uma abordagem complementar por Cristalografia de Raios-X, RMN e Química Computacional para a compreensão dos mecanismos de reconhecimento e ligação de substratos em módulos proteicos de ligação a polissacáridos
PTDC/QUI/68286/2006
PTDC/QUI/68286/2006
Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01 - 2009/04 Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes
82210
Provided by PTCRIS: 82210
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2007/01 - 2008/11 Structural and Functional Characterization of Nitrate Reductases and Formate Dehydrogenases
82151
Provided by PTCRIS: 82151
Researcher
Ministério da Ciência Tecnologia e Ensino Superior
2005/07/01 - 2007/12/31 Determinantes moleculares de especificidade em módulos de ligação a carbohidratos e complexos coesina-doquerina
POCI/BIA-PRO/59118/2004
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Correia, Viviana G.; Pinheiro, Benedita; Carvalho, Ana Luísa; Palma, Angelina S.. "Resistance to Aminoglycosides". 1-38. John Wiley & Sons, Ltd, 2019.
    10.1002/9781119282549.ch1
  2. Ribeiro, Diana O.; Pinheiro, Benedita A.; Carvalho, Ana Luísa; Palma, Angelina S.. "Targeting protein-carbohydrate interactions in plant cell-wall biodegradation: the power of carbohydrate microarrays". 2018.
    10.1039/9781788010641-00159
  3. Carvalho, Ana Luisa; Santos-Silva, Teresa; Romao, Maria Joao; Cabrita, Eurico J.; Marcelo, Filipa. "Structural Elucidation of Macromolecules". In Essential Techniques for Medical and Life Scientists: A Guide to Contemporary Methods and Current Applications with the Protocols, 30-91. BENTHAM SCIENCE PUBLISHERS, 2018.
    10.2174/9781681087092118010005
  4. Brás, Joana L.A.; Carvalho, Ana Luisa; Viegas, Aldino; Najmudin, Shabir; Alves, Victor D.; Prates, José A.M.; Ferreira, Luís M.A.; et al. "Escherichia coli Expression, Purification, Crystallization, and Structure Determination of Bacterial Cohesin–Dockerin Complexes". In Methods in Enzymology, 395-415. Elsevier, 2012.
    10.1016/b978-0-12-415931-0.00021-5
  5. Carvalho, Ana Luisa; Trincao, Jose; Romao, Maria Joao; Carvalho, A.L.; Trincão, J.; Romão, M.J.. "X-ray crystallography in drug discovery". In Methods in molecular biology (Clifton, N.J.), 31-56. 2010.
    Published
Conference poster
  1. Trovão, Filipa; Andrade Pinheiro, Benedita; Candeias, Alícia; Abrahams, Jodie; Di Maio, Antonio; Yu, Jin; Chai, Wengang; et al. "Molecular recognition on Mucin O-glycans by a human gut commensal ¿ Bacteroides caccae". Paper presented in Structural Glycoscience Summer School, 2023.
  2. Candeias, Alícia; Trovão, Filipa; Pinheiro, Benedita; Palma, Angelina S.; Carvalho, Ana Luísa. Corresponding author: Candeias, Alícia. "Structural basis for recognition of mucin O-glycans by a novel member of family 32 CBM from Bacteroides caccae". Paper presented in XIII Jornadas de Carbohidratos (Spanish Carbohydrate Meeting), 2023.
  3. Candeias, Alícia; Trovão, Filipa; Pinheiro, Benedita; Palma, Angelina S.; Carvalho, Ana Luísa. Corresponding author: Candeias, Alícia. "The 3D structure of BC16100-C, a novel protein from Bacteroides caccae, in complex with the Tn antigen reveals the molecular determinants that allow this bacterium to recognise host glycoproteins". Paper presented in GLUPOR14 - 14th International Meeting of the Portuguese Carbohydrate Group, 2023.
  4. Trovão, Filipa; Candeias, Alícia; Pinheiro, Benedita; Palma, Angelina S.; Carvalho, Ana Luísa. Corresponding author: Candeias, Alícia. "Structural insights on the glycan-binding function of a novel protein from Bacteroides caccae, a commensal bacterium from the human gut". Paper presented in 2nd National Crystallographic Meeting, 2022.
  5. Lima, Carlos D. L.; Coelho, Helena; Gimeno, Ana; Trovão, Filipa; Diniz, Ana; Dias, Jorge S; Jiménez-Barbero, Jesús; et al. "Deciphering the molecular recognition mechanism between human immune related lectins and the cancer and pathogenic glycobiomarker LacdiNAc". Paper presented in Summer School in Biomedical Glycoscience, 2022.
  6. Trovão, Filipa; Candeias, Alicia; Pinheiro, Benedita A.; Liu, Yan; Carvalho, Ana Luísa; Palma, Angelina S.. "Structural elucidation of novel glycan-binding proteins from Bacteroides caccae - a resident of the human gut microbiota.". Paper presented in Diamond-CCP4 Data Collection and Structure Solution Workshop, 2021.
  7. Trovão, Filipa; Correia, Viviana G.; Lourenço, Frederico; Carvalho, Ana Luísa; Palma, Angelina S.; Pinheiro, Benedita A.. "A special guest to PDB50: Bacteroides thetaiotaomicron, the human gut microbe that owns the required protein machinery to degrade complex pectic polysaccharides for us.". Paper presented in PDB50: A special symposium celebrating the 50th anniversary of the Protein Data Bank., 2021.
  8. Lima, Carlos D. L.; Coelho, Helena; Gimeno, Ana; Trovão, Filipa; Diniz, Ana; Dias, Jorge S; Jiménez-Barbero, Jesús; et al. "Understanding the difference on molecular recognition of LacdiNAc by immune-related lectins". Paper presented in 9th IberoAmerican NMR meeting (presented by Carlos D. L. Lima), 2021.
  9. Trovão, Filipa; Correia, Viviana G.; Lourenço, Frederico; Brás, Joana L. A.; Silva, Lisete M.; Paulsen, Berit S.; Feizi, Ten; et al. "Characterisation of a novel CBM from human gut microbiota provides further insight into the bacterial degradation of complex pectic polysaccharides.". Paper presented in 22nd EMBL PhD Symposium: The Roaring 20s, 2020.
  10. Andrade Pinheiro, Benedita; Ribeiro, Diana O.; Correia, Viviana G.; Costa, Raquel; Trovão, Filipa; Romão, Maria João; Carvalho, Ana Luísa; Palma, Angelina S.. "Glycan microarrays ¿ driving structural biology approaches to unravel glycan recognition". Paper presented in 1st Meeting COST Action CA18132, 2019.
  11. Trovão, Filipa; Gomes, Ana Sara; Andrade Pinheiro, Benedita; Gomes, Sara; Oliveira, Carla; Domingues, Lucília; Romão, Maria João; Saraiva, Lucília; Carvalho, Ana Luísa. "The loss of DNA binding function of a Human p53 mutant elucidated through X-ray crystallography". Paper presented in Ciência 2019, 2019.
  12. Trovão, Filipa; Gomes, Ana Sara; Andrade Pinheiro, Benedita; Gomes, Sara; Oliveira, Carla; Domingues, Lucília; Romão, Maria João; Saraiva, Lucília; Carvalho, Ana Luísa. "Crystal structure of Human p53 R280K mutant (DNA binding domain) ¿ Explaining the loss of DNA binding". Paper presented in 7th National Meeting of Portuguese Users of Synchrotron Radiation (ENURS), 2018.
  13. Correia, Viviana G.; Lourenço, Frederico; Trovão, Filipa; Brás, Joana L. A.; Andrade Pinheiro, Benedita; Silva, Lisete M.; Feizi, Ten; et al. "A novel pectin binding protein from the human gut microbiota". Paper presented in 7th National Meeting of Portuguese Users of Synchrotron Radiation (ENURS), 2018.
  14. Lourenço, Frederico; Leote, Catarina; Correia, Viviana G; Brás, Joana L. A; Fontes, Carlos M.G.A; Romão, Maria João; Carvalho, Ana Luísa; Palma, Angelina S.; Pinhero, Benedita A. "Assignment of biological roles for CBM57 modules in human gut bacteria". Paper presented in 6th National Meeting of Portuguese Synchrotron Radiation Users (ENURS), 2017.
  15. Najmudin, Shabir; Bule, Pedro; Venditto, Immacolata; Cameron, K; Pires, VMR; Bras, Joana L. A.; Freire, Filipe; et al. "Structural insights into the assembly and function of the Cellulosome from Clostridiato Ruminococci". Paper presented in 6th Meeting of Synchrotron Radiation Users from Portugal, 2017.
  16. Freire, Filipe; Aveiro, Susana S.; Maria Joao Romao; Goodfellow, Brian J.; Macedo, AL; Carvalho, Ana Luísa. "Structure determination of human SOUL protein by Se-SAD using synchrotron radiation". Paper presented in 1st Meeting of Synchrotron Radiation Users from Portugal, 2012.
  17. Viegas, Aldino; Freire, Filipe; Sardinha, João; Carvalho, Ana Luísa; Fontes, CMGA; Maria Joao Romao; Macedo, AL. "Solution Structure, Dynamics and Binding Studies of CtCBM11". Paper presented in 2nd PTNMR Meeting, 2012.
  18. Viegas, Aldino; Freire, Filipe; Carvalho, Ana Luísa; Maria Joao Romao; Cabrita, E. J.. "Insights into the mechanism of molecular selectivity and recognition by carbohydrate-binding modules from Clostridium thermocellum". Paper presented in 9th Carbohydrate Bioengineering Meeting, 2011.
  19. Viegas, Aldino; Freire, Filipe; Carvalho, Ana Luísa; Macedo, AL; Cabrita, E. J.. "The influence of Temperature and Binding on the Dynamics of CtCBM11". Paper presented in Conference CCPN Europa 2011 ¿Supporting best practice in biomolecular NMR¿, 2011.
  20. Freire, Filipe; Aveiro, Susana S.; Maria Joao Romao; Carvalho, Ana Luísa; Goodfellow, Brian J.; Macedo, AL. "NMR structural studies of the human SOUL". Paper presented in Conference CCPN Europa 2011 ¿Supporting best practice in biomolecular NMR¿, 2011.
  21. Dias, Fernando; García-Alvarez, B.; Melero, R; Prates, JAM; Smith, SP; Romão, MJ; Fontes, CMGA; Carvalho, Ana L.; Llorca, O. "Three-dimensional organization of a Clostridium thermocellum mini-cellulosome, revealed by cryo-electron microscopy.". Paper presented in 9th Carbohydrate Bioengineering Meeting, 2011.
  22. Freire, Filipe; Aveiro, Susana S.; Maria Joao Romao; Carvalho, Ana Luísa; Macedo, AL; Goodfellow, Brian J.. "Use of NMR to study the interaction of heme with Human SOUL". Paper presented in Joint EUROMAR 2010 and 17th ISMAR Conference, Worldwide Magnetic Resonance Conference, 2010.
  23. Brian James Goodfellow; Freire, Filipe; Aveiro, SS; Maria Joao Romao; Carvalho, Ana L.; Felix, VS; Micaelo, N; Ferreira, GC; Macedo, AL. "Structural studies of the SOUL/HBP Family of Heme-Binding Proteins". Paper presented in International BioIron Society 2009 Meeting, 2009.
  24. Freire, Filipe; Carvalho, Ana Luísa; Dias, JS; Ferreira, GC; Brian James Goodfellow; Maria Joao Romao; Macedo, AL. "Structural characterization of two heme-binding proteins from the HBP/SOUL family". Paper presented in 1st Portuguese-Spanish-British Joint Biophysics Congress, 2008.
  25. Freire, Filipe; Carvalho, Ana Luísa; Dias, JS; Ferreira, GC; Brian James Goodfellow; Maria Joao Romao; Macedo, AL. "An NMR Approach for the Structural and Dynamic Characterization of SOUL, a Heme-Binding Protein". Paper presented in IV Bienal del GERMN ¿ I Reunión Ibérica de RMN, 2008.
  26. Freire, Filipe; Carvalho, AL; Dias, JS; Ferreira, GC; Volkman, BF; Brian James Goodfellow; Romão, Maria; Macedo, AL. "Structural studies on two heme-binding proteins from the HBP/SOUL family; an integrated study by Crystallography and NMR". Paper presented in 8th Course: Biophysics and the Challenges of Emerging Threats, 2007.
  27. Catarina Guerreiro; Najmudin, Shabir; Carvalho, Ana L.; Correia, M. A. S.; Maria Joao Romao; Carlos MGA Fontes. "Structural basis for the promiscuous specificity of carbohydrate-binding modules from the beta-sandwich super-family". Paper presented in 7th Carbohydrate Bioengineering Meeting (CBM7), 2007.
  28. Fontes, CMGA; Carvalho, Ana L.; Dias, Fernando; Proctor, MR; Prates, JAM; Nagy, T; Smith, T; et al. "Identification of a dual binding mode in the cohesin-dockerin complexes.". Paper presented in 7th Carbohydrate Bioengineering Meeting, 2007.
  29. Freire, Filipe; Teresa Santos-Silva; Trincão, José; Carvalho, Ana Luísa; Bonifacio, Cecilia; Auchère, F; Raleiras, Patrícia; et al. "Class III Superoxide Reductase from Treponema pallidum". Paper presented in 8th International School on the Crystallography of Biological Macromolecules, 2006.
  30. Freire, Filipe; Teresa Santos-Silva; Trincão, José; Carvalho, Ana Luísa; Bonifacio, Cecilia; Auchère, F; Raleiras, Patrícia; et al. "Structural Characterization of the Superoxide Reductase from Treponema pallidum". Paper presented in XV National Congress of Biochemistry, 2006.
  31. José Mestre Prates; Najmudin, Shabir; Catarina Guerreiro; Carvalho, Ana Luísa; Correia, M. A. S.; Maria Joao Romao; Gilbert, Harry J.; Carlos MGA Fontes. "Crystal structure of novel CBMs that bind with equal affinity to cellulose and xyloglucan (CelJ CBM44 and CBM30)". Paper presented in XV National Congress of Biochemistry, 2006.
Journal article
  1. Ana Margarida Gonçalves Carvalho Dias; Inês Pimentel Moreira; Iana Lychko; Cátia Lopes Soares; Arianna Nurrito; Arménio Moura Barbosa; Viviane Lutz-Bueno; et al. "Hierarchical self-assembly of a reflectin-derived peptide". Frontiers in Chemistry 11 (2023): https://novaresearch.unl.pt/en/publications/e8af87b9-f51b-4c43-a8bd-831661072fd6.
    10.3389/fchem.2023.1267563
  2. José Malanho Silva; Linda Cerofolini; Carvalho, Ana Luísa; Enrico Ravera; Marco Fragai; Giacomo Parigi; Anjos L. Macedo; Carlos F. G. C. Geraldes; Claudio Luchinat. "Elucidating the concentration-dependent effects of thiocyanate binding to carbonic anhydrase". Journal of Inorganic Biochemistry 244 (2023): https://novaresearch.unl.pt/en/publications/3e9b4f0c-48cb-4d7f-8b18-0b541b154316.
    10.1016/j.jinorgbio.2023.112222
  3. Cláudia S. Nóbrega; Carvalho, Ana Luísa; Maria João Romão; Sofia R. Pauleta. "Structural Characterization of Neisseria gonorrhoeae Bacterial Peroxidase—Insights into the Catalytic Cycle of Bacterial Peroxidases". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24076246.
    10.3390/ijms24076246
  4. Marlene Duarte; Victor D. Alves; Márcia A. S. Correia; Catarina Caseiro; Luís M. A. Ferreira; Maria João Romão; Carvalho, Ana Luísa; et al. "Structure-function studies can improve binding affinity of cohesin-dockerin interactions for multi-protein assemblies". International Journal of Biological Macromolecules 224 (2023): 55-67. https://novaresearch.unl.pt/en/publications/602f601b-7b8e-49f9-959c-81142822b4e6.
    10.1016/j.ijbiomac.2022.10.102
  5. Trovão, Filipa; Correia, Viviana G.; Lourenço, Frederico M.; Ribeiro, Diana O.; Carvalho, Ana Luísa; Palma, Angelina S.; Pinheiro, Benedita A.. "The structure of a Bacteroides thetaiotaomicron carbohydrate-binding module provides new insight into the recognition of complex pectic polysaccharides by the human microbiome". Journal of Structural Biology: X 7 (2023): 100084. http://dx.doi.org/10.1016/j.yjsbx.2022.100084.
    10.1016/j.yjsbx.2022.100084
  6. Inês P. Moreira; Carina Esteves; Susana I. C. J. Palma; Efthymia Ramou; Carvalho, Ana Luísa; Roque, A.C.A.. "Synergy between silk fibroin and ionic liquids for active gas-sensing materials". Materials TodayBIO 15 (2022): https://novaresearch.unl.pt/en/publications/cf7e84c8-159e-498e-98d0-ff71edec80e8.
    10.1016/j.mtbio.2022.100290
  7. Esteves, Carina; Palma, Susana I. C. J.; Costa, Henrique M. A.; Alves, Cláudia; Santos, Gonçalo M. C.; Ramou, Efthymia; Carvalho, Ana Luísa; Alves, Vitor; Roque, Ana C. A.. "Tackling Humidity with Designer Ionic Liquid-Based Gas Sensing Soft Materials". Advanced Materials 34 8 (2022): 2107205. http://dx.doi.org/10.1002/adma.202107205.
    10.1002/adma.202107205
  8. Goodfellow, Brian J.; Freire, Filipe; Carvalho, Ana Luísa; Aveiro, Susana S.; Charbonnier, Peggy; Moulis, Jean-Marc; Delgado, Leonildo; et al. "The SOUL family of heme-binding proteins: Structure and function 15 years later". Coordination Chemistry Reviews 448 (2021): 214189. http://dx.doi.org/10.1016/j.ccr.2021.214189.
    10.1016/j.ccr.2021.214189
  9. Viviana G. Correia; Ana Sara Gomes; Benedita Pinheiro; Joana L. A. Brás; Lisete M. Silva; Cláudia Nunes; Manuel A. Coimbra; et al. Corresponding author: Carvalho, Ana Luísa. "Mapping Molecular Recognition of ß1,3-1,4-Glucans by a Surface Glycan-Binding Protein from the Human Gut Symbiont Bacteroides ovatus". Microbiology Spectrum 9 3 (2021): e0182621-e0182621. https://novaresearch.unl.pt/en/publications/0f923c5c-f2ec-49e8-9e48-6bf8356f6993.
    Published • 10.1128/Spectrum.01826-21
  10. Polino, M.; Rho, H. S.; Pina, M. P.; Mallada, R.; Carvalho, Ana Luísa; Romão, M. J.; Coelhoso, Isabel; et al. "Protein Crystallization in a Microfluidic Contactor with Nafion®117 Membranes". Membranes 11 8 (2021): 549. http://dx.doi.org/10.3390/membranes11080549.
    10.3390/membranes11080549
  11. Lima, Carlos D. L.; Coelho, Helena; Gimeno, Ana; Trovão, Filipa; Diniz, Ana; Dias, Jorge S.; Jiménez-Barbero, Jesús; et al. "Structural insights into the molecular recognition mechanism of the cancer and pathogenic epitope, LacdiNAc by immune-related lectins". Chemistry – A European Journal (2021): http://dx.doi.org/10.1002/chem.202100800.
    10.1002/chem.202100800
  12. Raquel dos Santos; Maria João Romão; Ana Cecília A. Roque; Carvalho, Ana Luísa. Corresponding author: Carvalho, Ana Luísa. "Magnetic particles used in a new approach for designed protein crystallization". CrystEngComm 23 5 (2021): 1083-1090. https://novaresearch.unl.pt/en/publications/8986cc88-9b6d-4de2-9427-6e161e3790eb.
    Published • 10.1039/d0ce01529f
  13. Duarte, Marlene; Viegas, Aldino; Alves, Victor D.; Prates, José A.M.; Ferreira, Luís M.A.; Najmudin, Shabir; Cabrita, Eurico J.; et al. Corresponding author: Carvalho, Ana Luísa. "A dual cohesin–dockerin complex binding mode in Bacteroides cellulosolvens contributes to the size and complexity of its cellulosome". Journal of Biological Chemistry 296 (2021): 100552. http://dx.doi.org/10.1016/j.jbc.2021.100552.
    Published • 10.1016/j.jbc.2021.100552
  14. Raquel Dos Santos; Inês Iria; Ana M. Manuel; Ana P. Leandro; Catarina Madeira; João Goncalves; Ana Luísa Carvalho; Ana Cecília Roque. "Magnetic Precipitation: A New Platform for Protein Purification". Biotechnology Journal 15 9 (2020): https://novaresearch.unl.pt/en/publications/7aa5e1f7-f218-482b-83c7-fd56698b6686.
    10.1002/biot.202000151
  15. Mani Outis; V. Rosa; César A. T. Laia; J. C. Lima; Barroso, S. B.; Ana Luísa Carvalho; Maria Jose' Calhorda; Avilés T.. "Synthesis, Crystal Structure, and DFT Study of Two New Dinuclear Copper(I) Complexes Bearing Ar-BIAN Ligands Functionalized with NO2 Groups". European Journal of Inorganic Chemistry 2020 30 (2020): 2900-2911. https://novaresearch.unl.pt/en/publications/42ec2745-9aa6-4475-9933-f0478dbba713.
    10.1002/ejic.202000423
  16. Ana Sara Gomes; Helena Ramos; Sara Gomes; Joana B. Loureiro; Joana Soares; Valentina Barcherini; Paola Monti; et al. "SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations". Biochimica et Biophysica Acta - General Subjects 1864 1 (2020): https://novaresearch.unl.pt/en/publications/835b29c1-bec5-44df-8a20-8167fd34ec7c.
    10.1016/j.bbagen.2019.129440
  17. Ribeiro, Diana O.; Viegas, Aldino; Pires, Virgínia M. R.; Medeiros-Silva, João; Bule, Pedro; Chai, Wengang; Marcelo, Filipa; et al. "Molecular basis for the preferential recognition of ß1,3-1,4-glucans by the family 11 carbohydrate-binding module from Clostridium thermocellum". The FEBS Journal 287 13 (2019): 2723-2743. http://dx.doi.org/10.1111/febs.15162.
    10.1111/febs.15162
  18. Peixoto, Daniela; Malta, Gabriela; Cruz, Hugo; Barroso, Sónia; Carvalho, Ana Luisa; Ferreira, Luisa Maria; Branco, Paula Serio. "N-Heterocyclic olefin catalysis for the ring opening of cyclic amidine compounds: a pathway to the synthesis of e-caprolactam and ¿-lactam-derived amines". The Journal of Organic Chemistry (2019):
    In press • 10.1021/acs.joc.8b02823
  19. Pedro Bule; Virgínia M. R. Pires; Victor D. Alves; Ana Luísa Carvalho; José A. M. Prates; Luís M. A. Ferreira; Steven P. Smith; et al. "Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction". Scientific Reports (2018):
    10.1038/s41598-018-25171-8
  20. Sabrina Santarsia; Ana Sofia Grosso; Filipa Trovão; Jesús Jiménez-Barbero; Ana Luísa Carvalho; Cristina Nativi; Filipa Marcelo. "Molecular recognition of a Thomsen-Friedenreich antigen mimetic targeting human galectin-3". ChemMedChem (2018):
    10.1002/cmdc.201800525
  21. Krishan Kumar; Márcia A. S. Correia; Virgínia M R Pires; Arun Dhillon; Kedar Sharma; Vikky Rajulapati; Carlos M G A Fontes; Ana Luísa Carvalho; Arun Goyal. Corresponding author: Ana Luísa Carvalho. "Novel insights into the degradation of ß-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase". International Journal Of Biological Macromolecules 117 (2018): 890-901.
    10.1016/j.ijbiomac.2018.06.003
  22. Peixoto, Daniela; Figueiredo, Margarida; Malta, Gabriela; Roma-Rodrigues, Catarina; Baptista, Pedro V.; Fernandes, Alexandra R.; Barroso, Sónia; et al. "Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H )-Anthrone". European Journal of Organic Chemistry 2018 4 (2018): 545-549.
    10.1002/ejoc.201701500
  23. Gomes, A. S.; Trovao, F.; Pinheiro, B. A.; Freire, F.; Gomes, S.; Oliveira, C.; Domingues, L.; et al. Corresponding author: Carvalho, A. L.. "The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding". International Journal of Molecular Sciences 19 4 (2018): 12-12.
    Published • 10.3390/ijms19041184
  24. Kryshtafovych, A.; Albrecht, R.; Basle, A.; Bule, P.; Caputo, A. T.; Carvalho, A. L.; Chao, K. L.; et al. "Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)". Proteins-Structure Function and Bioinformatics 86 (2018): 27-50.
    10.1002/prot.25392
  25. Pedro Bule; Victor D. Alves; Vered Israeli-Ruimy; Ana L. Carvalho; Luís M. A. Ferreira; Steven P. Smith; Harry J. Gilbert; et al. "Assembly of Ruminococcus flavefaciens cellulosome revealed by structures of two cohesin-dockerin complexes". Scientific Reports (2017):
    10.1038/s41598-017-00919-w
  26. Mariella Polino; Ana Luísa Carvalho; Lina Juknaite; Carla A.M. Portugal; Isabel Coelhoso; Maria João Romão; João Crespo. "Ion-Exchange Membranes for Stable Derivatization of Protein Crystals". Crystal Growth and Design 17 9 (2017): 4563-4572.
    10.1021/acs.cgd.7b00315
  27. Virgínia M R Pires; Pedro M. Pereira; Joana L A Brás; Márcia A. S. Correia; Vânia Cardoso; Pedro Bule; Victor D Alves; et al. "Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C". Journal of Biological Chemistry 292 12 (2017): 4847-4860.
    10.1074/jbc.M116.767541
  28. Magdalena Kowacz; Mateusz Marchel; Lina Juknaité; J. M. S. S. Esperança; Maria João Romão; Ana Luísa Carvalho; Luis Paulo Rebelo. Corresponding author: Ana Luísa Carvalho. "Infrared light-induced protein crystallization. Structuring of protein interfacial water and periodic self-assembly". Journal Of Crystal Growth 457 (2017): 362-368.
    10.1016/j.jcrysgro.2016.01.003
  29. dos Santos, Raquel; Carvalho, Ana Luisa; Roque, A. Cecilia A.. Corresponding author: Carvalho, Ana Luisa. "Renaissance of protein crystallization and precipitation in biopharmaceuticals purification". Biotechnology Advances 35 1 (2017): 41-50.
    10.1016/j.biotechadv.2016.11.005
  30. Hussain, A.; Semeano, A. T. S.; Palma, Sicj; Pina, A. S.; Almeida, J.; Medrado, B. F.; Padua, Accs; et al. "Tunable Gas Sensing Gels by Cooperative Assembly". Advanced Functional Materials 27 27 (2017): 9-9.
    10.1002/adfm.201700803
  31. Brás, Joana L. A.; Pinheiro, Benedita A.; Cameron, Kate; Cuskin, Fiona; Viegas, Aldino; Najmudin, Shabir; Bule, Pedro; et al. Corresponding author: Carvalho, Ana Luísa. "Diverse specificity of cellulosome attachment to the bacterial cell surface". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep38292.
    10.1038/srep38292
  32. Kowacz, M.; Marchel, M.; Juknaite, L.; Esperança, J. M. S. S; Romão, M. J.; Carvalho, A. L.; Rebelo, L. P. N.. Corresponding author: Carvalho, A. L.. "Ionic-Liquid-Functionalized Mineral Particles for Protein Crystallization". Crystal Growth & Design 15 6 (2015): 2994-3003. http://dx.doi.org/10.1021/acs.cgd.5b00403.
    10.1021/acs.cgd.5b00403
  33. Maria Angelina de Sá Palma; Yan Liu; Hongtao Zhang; Yibing Zhang; Barry V McCleary; Guangli Yu; Qilin Huang; et al. "Unravelling glucan recognition systems by glycome microarrays using the designer approach and mass spectrometry". Molecular & Cellular Proteomics 14 4 (2015): 974-988.
    10.1074/mcp.M115.048272
  34. Ribeiro, D.; Kulakova, A.; Quaresma, P.; Pereira, E.; Bonifacio, C.; Romao, M. J.; Franco, R.; Carvalho, A. L.. Corresponding author: Carvalho, A. L.. "Use of Gold Nanoparticles as Additives in Protein Crystallization". Crystal Growth & Design 14 1 (2014): 222-227.
    10.1021/cg4014398
  35. Viegas, Aldino; Sardinha, Joao; Freire, Filipe; Duarte, Daniel F.; Carvalho, Ana L.; Fontes, Carlos M. G. A.; Romao, Maria J.; et al. "Solution structure, dynamics and binding studies of a family 11 carbohydrate-binding module from Clostridium thermocellum (CtCBM11)". The Biochemical journal 451 2 (2013): 289-300.
    10.1042/bj20120627
  36. Ana Luísa Carvalho; Maria João Romão; Luis Paulo Rebelo; Magdalena Kowacz; J. M. S. S. Esperança. "Hofmeister effects of ionic liquids in protein crystallization: Direct and water-mediated interactions". CrystEngComm 14 15 (2012): 4912-4921.
    10.1039/c2ce25129a
  37. Pinheiro, B. A.; Bras, J. L. A.; Najmudin, S.; Carvalho, A. L.; Ferreira, L. M. A.; Prates, J. A. M.; Fontes, Cmga. "Flexibility and specificity of the cohesin-dockerin interaction: implications for cellulosome assembly and functionality". Biocatalysis and Biotransformation 30 3 (2012): 309-315.
    10.3109/10242422.2012.681854
  38. Bras, Joana L. A.; Alves, Victor D.; Carvalho, Ana Luisa; Najmudin, Shabir; Prates, Jose A. M.; Ferreira, Luis M. A.; Bolam, David N.; et al. "Novel Clostridium thermocellum Type I Cohesin-Dockerin Complexes Reveal a Single Binding Mode". The Journal of biological chemistry 287 53 (2012): 44394-405.
    10.1074/jbc.M112.407700
  39. Aveiro, S. S.; Freire, F.; Clayton, J.; Cameloc, M.; Carvalho, A. L.; Ferreira, G. C.; Romao, M. J.; Macedo, A. L.; Goodfellow, B. J.. "Structural studies of the p22HBP/SOUL family of heme-binding proteins". Febs Journal 279 (2012): 458-458.
  40. Bras, J. L. A.; Cartmell, A.; Carvalho, A. L. M.; Verze, G.; Bayer, E. A.; Vazana, Y.; Correia, M. A. S.; et al. Corresponding author: Carvalho, A. L. M.. "Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis". Proceedings of the National Academy of Sciences of the United States of America 108 13 (2011): 5237-5242. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288894800024&KeyUID=WOS:000288894800024.
    10.1073/pnas.1015006108
  41. Garcia-Alvarez, Begona; Melero, Roberto; Dias, Fernando M. V.; Prates, Jose A. M.; Fontes, Carlos M. G. A.; Smith, Steven P.; Romao, Maria Joao; Carvalho, Ana Luisa; Llorca, Oscar. "Molecular Architecture and Structural Transitions of a Clostridium thermocellum Mini-Cellulosome". Journal of Molecular Biology 407 4 (2011): 571-580. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288925200008&KeyUID=WOS:000288925200008.
    10.1016/j.jmb.2011.01.060
  42. Ana Luísa Carvalho; Natália de Fátima Teixeira Correia; Maria João Romão; DQ Group Author. "Real-Time Monitoring of Molecular Dynamics of Ethylene Glycol Dimethacrylate Glass Former". Journal Of Physical Chemistry B 113 43 (2009): 14209-14217. https://research.unl.pt/en/publications/realtime-monitoring-of-molecular-dynamics-of-ethylene-glycol-dimethacrylate-glass-former(fe8e55a5-aafd-4a2b-a60f-93347de9f37b).html.
    10.1021/jp903212g
  43. Freire, F.; Romão, M.J.; MacEdo, A.L.; Aveiro, S.S.; Goodfellow, B.J.; Carvalho, A.L.. Corresponding author: Carvalho, A.L.. "Preliminary structural characterization of human SOUL, a haem-binding protein". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65 7 (2009): 723-726. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149089746&partnerID=MN8TOARS.
    10.1107/S174430910902291X
  44. Godinho, M. H.; Filip, D.; Costa, I.; Carvalho, A. -L.; Figueirinhas, J. L.; Terentjev, E. M.. "Liquid crystalline cellulose derivative elastomer films under uniaxial strain". Cellulose 16 2 (2009): 199-205. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000263352900005&KeyUID=WOS:000263352900005.
    10.1007/s10570-008-9258-9
  45. Freire, F.; Macedo, A. L.; Aveiro, S. S.; Romao, M. J.; Carvalho, A. L.; Goodfellow, B. J.. "Structural and dynamic characterization of hSOUL, a heme-binding protein". Febs Journal 276 (2009): 139-140. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000267069900390&KeyUID=WOS:000267069900390.
  46. Viegas, Aldino; Brás, Natércia F.; Cerqueira, Nuno M. F. S. A.; Fernandes, Pedro Alexandrino; Prates, José A. M.; Fontes, Carlos M. G. A.; Bruix, Marta; et al. Corresponding author: Carvalho, Ana Luísa. "Molecular determinants of ligand specificity in family 11 carbohydrate binding modules - an NMR, X-ray crystallography and computational chemistry approach". FEBS Journal 275 10 (2008): 2524-2535. http://dx.doi.org/10.1111/j.1742-4658.2008.06401.x.
    10.1111/j.1742-4658.2008.06401.x
  47. José Pedro da Silva Trincão; José J. G. Moura; Pablo Javier Gonzalez; Ana Luísa Carvalho; Isabel Maria Andrade Martins Galhardas de Moura; Maria João Romão. "Heterodimeric nitrate reductase (NapAB) from Cupriavidus necator H16: purification, crystallization and preliminary X-ray analysis". Acta Crystallographica Section F-Structural Biology And Crystallization Com 63 NA (2007): 516-519. https://research.unl.pt/en/publications/heterodimeric-nitrate-reductase-napab-from-cupriavidus-necator-h16-purification-crystallization-and-preliminary-xray-analysis(d36d0822-7f80-4415-b022-3a4f09c10733).html.
    10.1107/S1744309107022129
  48. Carvalho, Ana Luisa; Dias, Fernando M. V.; Nagy, Tibor; Prates, Jose A. M.; Proctor, Mark R.; Smith, Nicola; Bayer, Edward A.; et al. "Evidence for a dual binding mode of dockerin modules to cohesins". Proceedings of the National Academy of Sciences of the United States of America 104 9 (2007): 3089-3094. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000244661400015&KeyUID=WOS:000244661400015.
    10.1073/pnas.0611173104
  49. Santos-Silva, T.; Trincão, J.; Carvalho, A.L.; Bonifácio, C.; Auchère, F.; Raleiras, P.; Moura, I.; Moura, J.J.G.; Romão, M.J.. "The first crystal structure of class III superoxide reductase from Treponema pallidum". Journal of Biological Inorganic Chemistry 11 5 (2006): 548-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745364810&partnerID=MN8TOARS.
    10.1007/s00775-006-0104-y
  50. Najmudin, S; Guerreiro, CIPD; Carvalho, AL; Prates, JAM; Correia, MAS; Alves, VD; Ferreira, LMA; et al. "Xyloglucan is recognized by carbohydrate-binding modules that interact with beta-glucan chains". Journal of Biological Chemistry 281 13 (2006): 8815-8828. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000236247100061&KeyUID=WOS:000236247100061.
    10.1074/jbc.M510559200
  51. Santos-Silva, T.; Trincão, J.; Carvalho, A.L.; Bonifácio, C.; Auchère, F.; Moura, I.; Moura, J.J.G.; Romão, M.J.. "Superoxide reductase from the syphilis spirochete Treponema pallidum: Crystallization and structure determination using soft X-rays". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61 11 (2005): 967-970. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744487895&partnerID=MN8TOARS.
    10.1107/S174430910502885X
  52. Carvalho, A.L.; Pires, V.M.R.; Gloster, T.M.; Turkenburg, J.P.; Prates, J.A.M.; Ferreira, L.M.A.; Romão, M.J.; et al. "Insights into the structural determinants of cohesin - Dockerin specificity revealed by the crystal structure of the type II cohesin from Clostridium thermocellum SdbA". Journal of Molecular Biology 349 5 (2005): 909-915. http://www.scopus.com/inward/record.url?eid=2-s2.0-20344372400&partnerID=MN8TOARS.
    10.1016/j.jmb.2005.04.037
  53. Carvalho, AL; Goyal, A; Prates, JAM; Bolam, DN; Gilbert, HJ; Pires, VMR; Ferreira, LMA; et al. "The family 11 carbohydrate-binding module of Clostridium thermocellum Lic26A-Cel5E accommodates beta-1,4- and beta-1,3-1,4-mixed linked glucans at a single binding site". Journal of Biological Chemistry 279 33 (2004): 34785-34793. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000223134800086&KeyUID=WOS:000223134800086.
    10.1074/jbc.M405867200
  54. Carvalho, AL; Dias, FMV; Prates, JAM; Nagy, T; Gilbert, HJ; Davies, GJ; Ferreira, LMA; Romao, MJ; Fontes, CMGA. "Cellulosome assembly revealed by the crystal structure of the cohesin-dockerin complex". Proceedings of the National Academy of Sciences of the United States of America 100 24 (2003): 13809-13814. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186803800015&KeyUID=WOS:000186803800015.
    10.1073/pnas.1936124100
  55. Carvalho, AL; Sanz, L; Barettino, D; Romero, A; Calvete, JJ; Romao, MJ. "Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: A homologue of human PSA". Journal of Molecular Biology 322 2 (2002): 325-337. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000178230500007&KeyUID=WOS:000178230500007.
    10.1016/S0022-2836(02)00705-2
  56. Carvalho, A. L.; Dias, J. M.; Sanz, L.; Romero, A.; Calvete, J. J.; Romao, M. J.; Carvalho, A.L.; et al. "Purification, crystallization and identification by X-ray analysis of a prostate kallikrein from horse seminal plasma". Acta Crystallographica Section D-Biological Crystallography 57 8 (2001): 1180-1183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000170041200025&KeyUID=WOS:000170041200025.
    10.1107/s0907444901009805
  57. Archer, M; Carvalho, AL; Teixeira, S; Moura, I; Moura, JJG; Rusnak, F; Romao, MJ. "Structural studies by X-ray diffraction on metal substituted desulforedoxin, a rubredoxin-type protein". Protein Science 8 7 (1999): 1536-1545. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000081271700019&KeyUID=WOS:000081271700019.
    10.1110/ps.8.7.1536
  58. Teixeira, S.; Dias, J. M.; Carvalho, A. L.; Bourenkov, G.; Bartunik, H.; Almendra, M. J.; Moura, I.; Moura, J. J. G.; Romao, M. J.. "Crystallographic studies on a tungsten-containning formate dehydrogenase from Desulfovibrio gigas". Journal of Inorganic Biochemistry 74 1-4 (1999): 89-89. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000081157700167&KeyUID=WOS:000081157700167.
  59. Romero, A.; Romao, M. J.; Varela, P. F.; Kolln, I.; Dias, J. M.; Carvalho, A. L.; Sanz, L.; TopferPetersen, E.; Calvete, J. J.. "The crystal structures of two spermadhesins reveal the CUB domain fold". Nature Structural Biology 4 10 (1997): 783-788. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997YA20300007&KeyUID=WOS:A1997YA20300007.
    10.1038/nsb1097-783
  60. Romao, M. J.; Kolln, I.; Dias, J. M.; Carvalho, A. L.; Romero, A.; Varela, P. F.; Sanz, L.; Topfer-Petersen, E.; Calvete, J. J.. "Crystal structure of acidic seminal fluid protein (aSFP) at 1.9 angstrom resolution: a bovine polypeptide of the spermadhesin family". Journal of Molecular Biology 274 4 (1997): 650-660. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071252400018&KeyUID=WOS:000071252400018.
    10.1006/jmbi.1997.1423
  61. Dias, J. M.; Carvalho, A. L.; Kolln, I.; Calvete, J. J.; TopferPetersen, E.; Varela, P. F.; Romero, A.; Urbanke, C.; Romao, M. J.. "Crystallization and preliminary x-ray diffraction studies of aSFP, a bovine seminal plasma protein with a single CUB domain architecture". Protein Science 6 3 (1997): 725-727. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997WM74000023&KeyUID=WOS:A1997WM74000023.
    10.1002/pro.5560060323
Magazine article
  1. Maria Joao Romao; Teresa Santos-Silva; Bento, I; Freire, Filipe; Marino Filipe Alves dos Santos; Carvalho, Ana Luísa. "Marcos Históricos em Cristalografia", Boletim da Sociedade Portuguesa de Química, 2015

Other

Dataset
  1. Carvalho, Ana Luísa; Carvalho, Ana L.; Carvalho, AL. My structures in the PDB. Up to January 2024, I have co-authored 54 entries in the Protein Data Bank.. https://docentes.fct.unl.pt/almc/links/structures-protein-data-bank.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/15 CBMcarb-DB, a novel curated database at the interface of the structural and functional knowledge on CBMs and their carbohydrate ligands 7th Iberian Carbohydrate Meeting
University of Barcelona (Sitges, Spain)
2023/06/05 A molecular view on how the human gut symbiont Bacteroides ovatus can recognize diet-derived health-promoting carbohydrates Affinity 2023
UCIBIO-FCT-NOVA (Lisbon, Portugal)
2021/10/15 A molecular view on the carbohydrate preferences of highly efficient cellulolytic bacteria XXI Congress of the Portuguese Biochemistry Society
(Évora, Portugal)
2019/09/04 Investigating the ligand-specificity of a Carbohydrate-Binding protein Module from Clostridium thermocellum: a biotechnological tool to target ß1,3-1,4-mixed-linked glucans GLUPOR13
Universidade do Porto, i3S (Porto, Portugal)
2019/01/09 X-Ray Crystallography in Drug Development: the case study of Galectin-3 and the Thomsen-Friedenreich Antigen Mimetic Seminar of the I3DU PhD Program
Universidade de Lisboa, Faculdade de Farmácia
2018/06/22 Investigating the carbohydrate preferences of cellulolytic bacteria 6th International Iberian Biophysics Congress
University Jaume I, Castellón (Spain)
2017/07/26 X-Ray Crystallography to investigate molecular interactions: seeing is believing Ist Symposium of the Biomolecular Engineering Lab
Biomolecular Engineering Lab, FCT-NOVA
2017/07/17 Integrative Structural Biology tools for the study of protein-ligand interactions PCISBIO Day
ITQB-NOVA
2014/08/10 The use of Gold Nanoparticles as Additives in Protein Crystallization IUCr Meeting
(Montreal, Canada)
2014/07/17 Protein-ligand interactions investigated using X-Rays and Glycoarrays PCISBIO Day
ITQB-NOVA
2011/01/14 A structural biology contribution to the understanding of bio-ethanol production Encontro REQUIMTE (Highlights Ciência2010)
REQUIMTE-FCT-NOVA
2010/07/27 Carbohydrate Binding Modules, a Driving Force behind Cellulose Recognition and Degradation in the Microbial World Session for Young Scientists at IBIO2010, BIT’s 3rd Annual World Congress of Industrial Biotechnology
(Dalian, China)
2010/07/04 A structural biology contribution to the understanding of bio-ethanol production Ciência2010
FCT-MCTES, Lisbon Congress Center (Lisbon)
2010/03/31 Protein-protein interactions determine the assembly of cellulosomes in Clostridium thermocellum Meeting Protein-Protein Interactions and Protein Folding
FCT-NOVA
2009/03/19 The Cellulosome: a nano-machine for the degradation of cellulose Conference cycle of Facolta' di Scienze - Università degli Studi di Verona
Facolta' di Scienze - Università degli Studi di Verona (Verona, Italy)
2008/02/17 The Cellulosome from Clostridium thermocellum: Building the Puzzle EMBO Practical course: Combination of electron microscopy and X-ray crystallography
(Gif-sur-Ivette, France)
2007/01/29 My research activities and scientific achievements as member of the Associate Laboratory REQUIMTE Sessões Científicas do Departamento de Química da FCT-UNL
2005/04/13 A estrutura do Cellulosoma: um mega-complexo de proteínas destinado à degradação da celulose – Um estudo por Cristalografia de Raios-X XXIV Ciclo de Conferências do DQ, Departamento de Química da FCT-UNL
2004/01/09 Cellulosome assembly and the crystal structure of the Cohesin-Dockerin complex 3º meeting ReQuimTe
FCT-NOVA
2003/09/19 Os Cristais de Proteína como Biocatalisadores DQ seminars
FCT-NOVA
2000/10/11 Protein Identification and Sequencing by Crystallography: The Crystal Structure of Horse Prostate Kallikrein at 1.42 Å resolution IBValencia Seminars
Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas (Valencia, Spain)
1999/04/07 Crystallographic studies on a Xanthine Oxidase purified from Rat Liver DQ seminars
FCT-NOVA

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/12/01 - Current Translating the human-microbiome molecular cross-talk using glycan microarray and structural biology strategies Ref: SFRH/BD/143494/2019
Co-supervisor of Filipa Grifo Trovão
 Biochemistry (PhD)
Universidade Nova de Lisboa, Portugal
2016 - 2023/12/21 Deciphering the human-microbiome glyco-code: an integrative approach to uncover protein-glycan interactions in the gut environment Ref: PD/BD/135517/2018
Co-supervisor of Raquel Lopes Costa
 Biociências Moleculares (PhD)
Universidade Nova de Lisboa, Portugal
2015 - 2023/12/20 Deciphering carbohydrate:protein interactions in the Human Microbiome – A combined high-throughput and structural approach Ref: PD/BD/105727/2014
Co-supervisor of Viviana Correia
 Biociências Moleculares (PhD)
Universidade Nova de Lisboa, Portugal
2021 - 2022 A molecular view on how a commensal bacterium thrives in the human gut
Supervisor of Alícia Candeias
 Biochemistry (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2021/01/26 Protein-carbohydrate recognition by the human commensal Bacteroides thetaiotaomicron: expression, purification and preliminary 3D structure solution of highly specific proteins
Co-supervisor of André Griffin de Almeida Favinha
 MSc in Biochemistry (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2020/03 Protein-carbohydrate recognition in the biodegradation of the plant cell wall: Functional and structural studies using carbohydrate microarrays and X-ray crystallography
Co-supervisor of Diana de Oliveira Ribeiro
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2020 Novel strategies for antibody purification through crystallization Ref: PD/BD/105753/2014
Supervisor of Raquel Santos
 Biociências Moleculares (PhD)
Universidade Nova de Lisboa, Portugal
2018/02/01 - 2019/01/31 MSc Fellow hired under project PTDC/BBB-BEP/0869/2014
Supervisor of Filipa Trovão
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017/02/01 - 2018/01/31 MSc Fellow hired under project PTDC/DTP-FTO/1981/2014
Supervisor of Filipa Trovão
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017 - 2018 Post-Doctoral Fellow hired under project PTDC/BIA-MIC/5947/2012
Supervisor of Benedita Pinheiro, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2016 - 2017 Post-Doctoral Fellow hired under project PTDC/BBB-BEP/0869/2014
Supervisor of Benedita Pinheiro, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015 - 2017 Ligand discovery and structural-functional analysis of proteins involved in plant cell wall degradation
Co-supervisor of Raquel Costa
 Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2016 Post-Doctoral Fellow hired under project RECI/BBB-BEP/0124/2012
Supervisor of Ramesh Pandian, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2014 - 2015 Structural characterization of glyco-proteins from the envelope of HIV-2 virus
Co-supervisor of Elizabeth Nelly Pires
 Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Post-Doctoral Fellow hired under project PTDC/BBB-BEP/3058/2012
Supervisor of Lina Juknaité, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2014 - 2015 Post-Doctoral Fellow hired under project RECI/BBB-BEP/0124/2012
Supervisor of Isabel Bento, PhD
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2013 - 2014 Structural characterization of glyco-proteins from the envelope of HIV-2 virus
Supervisor of Tiago Mestre
 Bioquímica (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2012 Using gold nanoparticles in protein crystallography: Studies in crystal growth and derivatization
Co-supervisor of Diana Ribeiro
 Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009 - 2012 Molecular determinants of ligand specificity in carbohydrate-binding modules: an NMR and X-ray crystallography integrated study
Co-supervisor of Aldino José Martins Viegas
 Bioquímica (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - 2009 Structural characterization of an exocellulase from the Cellulosome of Clostridium thermocellum
Co-supervisor of Genny Verzé
 Biochemistry (Master)
Università degli Studi di Verona, Italy

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/09/25 - 2023/09/28 GlycoTwinning Summer School "Scientific Hands-on course in protein/glycan interactions: a structural perspective. NMR, X-ray crystallography, cryoEM and molecular modelling." (2023/09/25 - 2023/09/28)
Workshop (Co-organisor)
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2023/01/16 - 2023/01/18 Member of the Organising Committee of the 14th International Meeting of the Portuguese Carbohydrate Group – GLUPOR 14 (2023/01/16 - 2023/01/18)
Conference (Member of the Organising Committee)
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Sociedade Portuguesa de Química, Portugal
2022/07/10 - 2022/07/15 7th European Crystallographic School (ECS7) (2022/07/10 - 2022/07/15)
Other (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/07/13 - 2015/07/19 ISBio2015: Integrative Structural Biology tools for the study of protein-ligand interactions (2015/07/13 - 2015/07/19)
Other (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 2014, International Year of Crystallography at FCT-NOVA (http://xtal.dq.fct.unl.pt/iycr2014), includes regular conferences by national and international speakers, a photo contest (Crystals & Symmetry in Art, Science and Life) and an exhibition, from April 2014 to July 2015. (2014 - 2015)
Symposium (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/10/06 - 2014/10/12 ISBio2014: Integrative Structural Biology tools for the study of protein-ligand interactions (2014/10/06 - 2014/10/12)
Other (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2011 2011, International Year of Chemistry at FCT-UNL (http://www.dq.fct.unl.pt/IYC2011). (2010 - 2011)
Symposium (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/02/09 Production and characterization of odorant-binding proteins
(Thesis) Main arguer
 Joana Ramos dos Santos Calvário (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/01/21 Deciphering the structural features of glycan-lectin interactions in the immune system
(Thesis) Main arguer
 Carlos David Lourenço Lima (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/06/05 Developing non-chromatographic strategies for biopharmaceuticals purification
Supervisor
 Raquel Alexandra Ribeiro dos Santos (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/10/30 Design and production of peptide-based scaffolds for bioengineering applications
(Thesis) Main arguer
 Iana Lychko (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/12/09 Production of membrane histidine kinases and structural studies on Thiosulfate dehydrogenase
(Thesis) Main arguer
 Alina Vitaliyivna Kulakova (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/06/12 Discovering novel Carbohydrate-Active Enzymes in the cellulosome of anaerobic bacteria
(Thesis) Main arguer
 Vânia Ondina Pedro Fernandes (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2014/12/17 Structural and functional studies of a high activity NiFeSe hydrogenase
(Thesis) Arguer
 Marta Franco Coimbra Marques (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/06/11 Deficiência na Desidrogenase dos Ésteres de Acil-Coenzima A de Cadeia Média (MCAD): caracterização de nova formas mutantes
(Thesis) Main arguer
 Joana Rita Luís Nunes (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/11/20 Structure and function relationships in novel cellulosomal enzymes and cohesin-dockerin complexes
(Thesis) Main arguer
 Joana Luís Armada Brás (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2012/09/21 Integrated study by NMR and X-Ray Crystallography on the analysis of the molecular interactions in Heme-Binding Proteins
Thesis Member
 Filipe Miguel dos Santos Freire (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/05/28 Molecular determinants of ligand specificity in carbohydrate-binding modules: and NMR and X-ray Crystallography integrated study
Supervisor
 Aldino José Martins Viegas (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/11/29 Rational use of dietary enzymes and lipids to improve broiler performance and meat quality
Thesis Member
 Teresa Paula Costa Ribeiro (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2010/10/08 Biochemical and structural studies on the PhoR-PhoB two component regulatory system from Deinococcus radiodurans
(Thesis) Arguer
 Sofia Maria Dias de Gouveia Caria (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/02/08 Novel insight into the mechanism of cellulosome assembly and plant cell wall hydrolysis in anaerobic bacteria
(Thesis) Main arguer
 Benedita Andrade Pinheiro (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009/03/19 Expression and purification of human muscleblind-like-protein-1 and structural characterization of an exocellulase from Clostridium thermocellum
(Thesis) Main arguer
 Genny Verzé (Master)
2008/11/21 Structural studies on family III alcohol dehydrogenases from pathogenic bacteria
(Thesis) Arguer
 David Marçal (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007/07/25 Estrutura e função de hemicelulases e complexos coesina-doquerina: implicações na hidrólise de polissacáridos estruturais da parede celular vegetal
(Thesis) Main arguer
 Fernando Manuel Vaz Dias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2006/11/13 Structural Characterization of Heme and Non-Heme Iron-Containing Proteins
Thesis Member
 Teresa Sacadura Santos Silva (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Association member

Society Organization name Role
2016 - Current Portuguese Chemistry Society
1998 - Current Portuguese Biophysics Society
1998 - Current Portuguese Biochemistry Society

Committee member

Activity description
Role 		Institution / Organization
2023 - Current UCIBIO Working Group Funding
Member
2022 - Current Coordinator of the UCIBIO-NOVA node of the CryoEM-PT National Roadmap Infrastructure
Coordinator
2021 - Current Thesis Advisory Committee of PhD student Carlos Costa (Molecular Biosciences)
President / Vice-president
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - Current Thesis Advisory Committee of PhD student Filipa Grifo Trovão (Structural Biology)
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2003 - Current Coordinator the X-ray Diffraction Facility of UCIBIO-FCT-NOVA
Coordinator
2003 - Current Coordinator of the UCIBIO team of the Portuguese Block Allocation Group (BAG-Portugal)
Coordinator
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2018 - 2023/12/21 Thesis Advisory Committee of PhD student Raquel Lopes Costa
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2023/12/19 Thesis Advisory Committee of PhD student Viviana Correia
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - 2023 Coordinator of Working Group 1 (Networking & Fundraising Opportunities) of UCIBIO-FCT-NOVA
Coordinator
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2016 - 2023 Member of Working Group 3 (Equipment & Infrastructures) of UCIBIO-FCT-NOVA
Member
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2020/02/01 - 2022/02/28 Scientific Commission of the Biochemistry Section
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2020 Scientific Council of FCT-NOVA (substitute member)
Other
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2020 Thesis Advisory Committee of PhD student Diana de Oliveira Ribeiro
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2020 Thesis Advisory Committee of PhD student Raquel Santos
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2015 Scientific Council of FCT-NOVA
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2014 Commission for the Scientific Matters of the Scientific Council
Member
2012 - 2014 Substitute Evacuation Coordinator of the Internal Emergency Plan of the TOMO 3 - Edifício Departamental (Chemistry wing)
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009 - 2012 Scientific Council of FCT-NOVA (substitute member)
Other
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Conference scientific committee

Conference name Conference host
2022/07/15 - 2022/07/16 2nd National Crystallographic Meeting Instituto Superior Técnico

Consulting

Activity description Institution / Organization
2014 - Current Web design, feed and maintenance of websites (https://sites.fct.unl.pt/glycoselect, https://sites.fct.unl.pt/cryoem-at-nova, http://sites.fct.unl.pt/xtal, https://sites.fct.unl.pt/pcisbio/, http://xtal.dq.fct.unl.pt/iycr2014, https://www.facebook.com/XtalNOVA, https://twitter.com/XTALUCIBIOFCTN1, https://eventos.fct.unl.pt/isbio) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2005 - Current Peer-reviewing in international journals: Acta Crystallographica Section F, Crystals, Journal of Biological Inorganic Chemistry, Chemical Physics Letters, Journal of Applied Crystallography, Journal of Crystal Growth https://publons.com/researcher/1327109/ana-luisa-carvalho/peer-review/
2019/10/16 - 2019/10/20 Invited evaluator of the Innovate Competition, from the iMed Conference® 11.0 – Lisbon
2006 - 2012 Translation activities to Journal Science in School (http://www.scienceinschool.org/). I contribute to this project by translating to Portuguese several articles that I find of interest to young students. After translation, the articles are made available online.

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2007 - Current Support, on an yearly basis, to the Disciplines Fundamentos de Bioquímica Estrutural (undergraduate) e Bioquímica Estrutural (MSc students) (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/09/25 - 2023/09/28 X-ray Crystallography module of the GlycoTwinning Summer School "Scientific Hands-on course in protein/glycan interactions: a structural perspective. NMR, X-ray crystallography, cryoEM and molecular modelling." (Pós-Graduação) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2020/07/27 - 2020/07/27 UCIBIO Summer School, Programa “Ciência no Verão” FCT-MCTES, Lesson on Biological Macromolecules, 27 July, FCT-NOVA (Curso de doutoramento (conclusão de unidades curriculares)) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2018/07/18 - 2018/07/19 Workshop Cristalografia de Raios-X, 18-19 July, UCIBIO-FCT-NOVA (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/07/13 - 2015/07/19 Co-organizer of International hands-on Course ISBio2015: Integrative Structural Biology tools for the study of protein-ligand interactions, 13-19 Julho, DQ-FCT-NOVA. INSTRUCT/COST supported training course (Outros)
2014/10/06 - 2014/10/12 Co-organizer of international hands-on Course ISBio2014: Integrative Structural Biology tools for the study of protein-ligand interactions, 6-12 October, DQ-FCT-NOVA. INSTRUCT/COST supported training course (Outros)
2012/07/11 - 2012/07/24 Summer Course 2012: Hands-On Course in Proteins and Proteomics, 11-24 July, FCT-UNL (co-organization and teaching in the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/07/11 - 2010/07/24 Summer Course 2010: Hands-On Course in Proteins and Proteomics, 11-24 July, FCT-UNL (co-organization and teaching in the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/02/01 - 2010/02/05 REQUIMTE Advanced Course 2010: Protein Crystallography, 1-5 February, FCT-UNL (co-organization and teaching). (Outros) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2009/07/07 - 2009/09/18 Summer Course 2009: Hands-On Course in Proteins and Proteomics, 7-18 September, FCT-UNL (co-organization and teaching; supervisor of the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/07/12 - 2008/07/25 Summer Course 2008: Hands-On Course in Proteins and Proteomics, 12-25 July, FCT-UNL (co-organization and teaching; supervisor of the X-ray Crystallography module). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2000 - 2007 Curso Monográfico editions: 2007, 2004, 2001, 2000: Cristalografia de Proteínas, FCT-NOVA (co-organization and teaching). (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Interview (tv / radio show)

Program Topic
2023/09/28 - 2023/09/28 Video-report of the 1st GlycoTwinning Summer School https://youtu.be/4JKdNzOVtkI?si=8sQgswPTMtTHVpfZ
2010 - 2010 Encontro Ciência2010; Session "Bio-Energia e Biocombustíveis". A structural biology contribution to the understanding of bio-ethanol production
2002 - 2002 Antena 1 PhD thesis subject
Distinctions

Award

2023 Best Poster award to PhD student Raquel Costa
NZYTech Lda, Portugal

Sociedade Portuguesa de Química, Portugal
2022 Gilead Genese award to team led by Pedro Bule
Gilead Genese, Portugal
2021 Best Poster Award to PhD student Filipa Trovão
Diamond Light Source Ltd, United Kingdom
2020 Best Poster Award to PhD student Raquel Costa
Diamond Light Source Ltd, United Kingdom
2018 IUCr Young Scientist Award, ECM31 in Oviedo, Spain (attributed to PhD student Raquel Santos)
2016 Best poster award at GlycoSummerSchool, Groningen, Alemanha (attributed to PhD student Viviana Correia)
2015 Best poster award at GLUPOR11 (attributed to PhD student Diana Ribeiro)
2014 Best poster award at 3rd ENURS & ESRF Day (attributed to post-graduate student Viviana Correia)
Instituto Politécnico de Leiria, Portugal
2014 Best poster award at 1st FEBS-INSTRUCT Crystallization Course: Advanced methods in macromolecular crystallization VI, Nové Hrady, Czech Republic (attributed to PhD student Diana Ribeiro)
2013 Scientific Merit Prize Santander-Totta/Universidade Nova de Lisboa
Santander-Totta/Universidade Nova de Lisboa, Portugal
2013 Bluepharma / Universidade de Coimbra Innovation Award
Bluepharma, Portugal
2013 António Xavier Prize awarded to my PhD student Aldino Viegas, for the Best National Thesis in the field of NMR
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 Best poster award at the 9th Congress Carbohydrate Bioengeneering Meeting (attributed to PhD student Aldino Viegas)
2006 2nd best poster presentation award at III Bienal of GERMN (attributed to PhD student Aldino Viegas)

Other distinction

2002 Post-doctoral scholarship SFRH/BPD/9446/2002
Fundação para a Ciência e a Tecnologia, Portugal
1998 PhD scholarship PRAXIS XXI/BD/15763/98
Fundação para a Ciência e a Tecnologia, Portugal
1996 MSc scholarship PRAXIS XXI/BM/7221/95
Fundação para a Ciência e a Tecnologia, Portugal