| Journal article |
- Pereira, Andreia; Mendonca, Maria Isabel; Borges, Sofia; Sousa, Ana Célia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana;
et al. "Additional value of a combined genetic risk score to standard cardiovascular stratification". Genetics and Molecular
Biology 41 4 (2018): 766-774. http://dx.doi.org/10.1590/1678-4685-gmb-2017-0173.
10.1590/1678-4685-gmb-2017-0173
- Sousa, Ana Célia; Reis, Roberto Palma dos; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Gouveia, Sara;
et al. "Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa População Portuguesa". Acta Médica
Portuguesa 31 10 (2018): 542. http://dx.doi.org/10.20344/amp.9184.
Open access • 10.20344/amp.9184
- Sousa, Ana Célia; Reis, Roberto Palma dos; Pereira, Andreia; Borges, Sofia; Gouveia, Sara; Spínola, Adelaide; Freitas, Ana
Isabel; et al. "A variante genética c825t da subunidade ß3 da proteína G associa-se com a hipertensão arterial numa população
portuguesa". Revista Portuguesa de Cardiologia 37 6 (2018): 499-507. http://dx.doi.org/10.1016/j.repc.2017.09.018.
Open access • 10.1016/j.repc.2017.09.018
- Brehm, António. "Sebastião e o cometa espantoso. O cometa de 1577, os avisos de céu e as crónicas sebastianistas". (2018):
http://hdl.handle.net/10400.13/2281.
- Pereira, Andreia; Mendonça, Maria Isabel; Borges, Sofia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; Freitas, Ana
Isabel; et al. "Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic
Risk Score of 31 Variants". Abstract Background: Genetic risk score can quantify individual’s predisposition to coronary
artery disease; however, its usefulness as an independent risk predictor remains inconclusive. Objective: To evaluate the
incremental predictive value of a genetic risk score to traditional risk factors associated with coronary disease. Methods:
Thirty-three genetic variants previously associated wit (2018): http://hdl.handle.net/10400.26/25692.
10.5935/abc.20180107
- Pereira,Andreia; Mendonca,Maria Isabel; Borges,Sofia; Sousa,Ana Célia; Freitas,Sónia; Henriques,Eva; Rodrigues,Mariana; et
al. "Additional value of a combined genetic risk score to standard cardiovascular stratification". The utility of genetic
risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus
GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566
coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined
for 32 (2018): http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500766.
https://doi.org/10.1590/1678-4685-gmb-2017-0173
- Sousa, Ana Célia; Palma dos Reis, Roberto; Pereira, Andreia; Borges, Sofia; Gouveia, Sara; Spínola, Adelaide; Freitas, Ana
Isabel; et al. "A variante genética c825t da subunidade ß3 da proteína G associa-se com a hipertensão arterial numa população
portuguesa". (2018): http://hdl.handle.net/10400.26/27893.
10.1016/j.repc.2017.09.018
- Sousa, Ana Célia; Reis, Roberto Palma; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Gouveia, Sara;
et al. "Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa População Portuguesa". Introdução:
A hipertensão arterial é uma doença complexa, multifatorial, controlada por fatores genéticos e ambientais.Objetivo: Avaliar
a susceptibilidade genética no aparecimento de hipertensão arterial e sua associação com os fatores de risco tradicionais
na eclosão desta patologia.Material e Métodos: Estudo caso-controlo com 1712 indivíduos, idade média de 51,0 ± 7,9 anos (860
hipertensos e 85 (2018): http://www.scopus.com/inward/record.url?scp=85055909462&partnerID=8YFLogxK.
https://doi.org/10.20344/amp.9184
- Gomes, Iva; Pereira, Plácido J.P.; Harms, Sonja; Oliveira, Andréa M.; Schneider, Peter M.; Brehm, António. "Genetic characterization
of Guinea-Bissau using a 12 X-chromosomal STR system: Inferences from a multiethnic population". Forensic Science International:
Genetics 31 (2017): 89-94. http://dx.doi.org/10.1016/j.fsigen.2017.08.016.
Open access • 10.1016/j.fsigen.2017.08.016
- Spínola, H.; Lemos, A.; Couto, A. R.; Parreira, B.; Soares, M.; Dutra, I.; Bruges-Armas, J.; Brehm, A.; Abreu, S.. "Human
leucocyte antigens class II allele and haplotype association with Type 1 Diabetes in Madeira Island (Portugal)". International
Journal of Immunogenetics 44 6 (2017): 305-313. http://dx.doi.org/10.1111/iji.12335.
Open access • 10.1111/iji.12335
- Afilal, Driss; Basselam, Mohamed Amine; Brakez, Zahra; Chouham, Said; Brehm, António; Izaabel, El Hassan. "Genetic Polymorphism
of Drug-Metabolizing Enzymes CYP2C9 and CYP2C19 in Moroccan Population". Genetic Testing and Molecular Biomarkers 21
5 (2017): 298-304. http://dx.doi.org/10.1089/gtmb.2016.0304.
Open access • Published • 10.1089/gtmb.2016.0304
- Silventoinen, Karri; Gouveia, Élvio; Jelenkovic, Aline; Maia, José; Antunes, António M.; Carvalho, Miguel A A Pinheiro de;
Brehm, António M; et al. "The Genetic Background of Metabolic Trait Clusters in Children and Adolescents". Metabolic Syndrome
and Related Disorders 15 7 (2017): 329-336. http://hdl.handle.net/10400.13/2197.
Open access • Published • 10.1089/met.2017.0013
- Sousa, Ana Célia; Mendonça, Maria I.; Pereira, Andreia; Gouveia, Sara; Freitas, Ana I.; Guerra, Graça; Rodrigues, Mariana;
et al. "Synergistic Association of Genetic Variants with Environmental Risk Factors in Susceptibility to Essential Hypertension".
(2017): http://hdl.handle.net/10400.26/28007.
10.1089/gtmb.2017.0048
- Sousa, Ana Célia; Palma dos Reis, Roberto; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Góis, Teresa;
et al. "Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island". Essential
hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis.
The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The
objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population
from (2017): http://hdl.handle.net/10400.26/27891.
10.1097/MD.0000000000007861
- Brehm, António Manuel Dias. "Auto de entrega do corpo de D. Sebastião: Ceuta, 10 de dezembro de 1578". (2017): http://hdl.handle.net/10400.13/1516.
- Pereira, Andreia; Mendonca, Maria Isabel; Sousa, Ana Célia; Borges, Sofia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana;
et al. "Genetic risk score and cardiovascular mortality in a southern european population with coronary artery disease". Several
genetic risk scores (GRS) have been associated with cardiovascular disease; their role, however, in survival from proven coronary
artery disease (CAD) have yielded conflicting results. Objective: The objective of this study was to evaluate long- term cardiovascular
mortality according to the genetic risk score in a Southern European population with CAD. Methods: A cohort of 1464 CAD patien
(2017): http://hdl.handle.net/10400.26/25696.
10.1111/ijcp.12956
- Spínola, H.; Lemos, A.; Couto, A. R.; Parreira, B.; Soares, M.; Dutra, I.; Bruges-Armas, J.; Brehm, A.. "HLA-DQA1 and HLA-DQB1
allele diversity and its extended haplotypes in Madeira Island (Portugal)". International Journal of Immunogenetics
44 1 (2016): 27-31. http://dx.doi.org/10.1111/iji.12300.
Open access • 10.1111/iji.12300
- Pereira, A.; Palma dos Reis, R.; Rodrigues, R.; Sousa, A. C.; Gomes, S.; Borges, S.; Ornelas, I.; et al. "Association of ADAMTS7
gene polymorphism with cardiovascular survival in coronary artery disease". Physiological Genomics 48 11 (2016): 810-815.
http://dx.doi.org/10.1152/physiolgenomics.00059.2016.
Open access • 10.1152/physiolgenomics.00059.2016
- Gomes, Iva; Brehm, António; Gusmão, Leonor; Schneider, Peter M.. "New sequence variants detected at DXS10148, DXS10074 and
DXS10134 loci". Forensic Science International: Genetics 20 (2016): 112-116. http://dx.doi.org/10.1016/j.fsigen.2015.10.005.
Open access • 10.1016/j.fsigen.2015.10.005
- Berenguer, Anabela G.; Rosa, Alexandra; Brehm, António. "Asthma—snapshot or motion picture?". Frontiers in Genetics
4 (2013): http://dx.doi.org/10.3389/fgene.2013.00073.
Open access • 10.3389/fgene.2013.00073
- Kheradmand Kia, Sima; Verbeek, Elly; Engelen, Erik; Schot, Rachel; Poot, Raymond A.; de Coo, Irenaeus F.M.; Lequin, Maarten H.;
et al. "RTTN Mutations Link Primary Cilia Function to Organization of the Human Cerebral Cortex". The American Journal
of Human Genetics 91 3 (2012): 533-540. http://dx.doi.org/10.1016/j.ajhg.2012.07.008.
Open access • 10.1016/j.ajhg.2012.07.008
- Brehm, Antonio ; Berenguer, Anabela Gonçalves; Câmara, Rita A. "Distribution of polymorphisms IL4-590 C/T and IL4 RP2 in the
human populations of Madeira, Azores, Portugal, Cape Verde and Guinea-Bissau". 3 2 (2012): 179-183.
Open access • Published
- Fernandes, Ana Teresa; Gonçalves, Rita; Gomes, Sara; Filon, Dvora; Nebel, Almut; Faerman, Marina; Brehm, António. "Y-chromosomal
STRs in two populations from Israel and the Palestinian Authority Area: Christian and Muslim Arabs". Forensic Science International:
Genetics 5 5 (2011): 561-562. http://dx.doi.org/10.1016/j.fsigen.2010.08.005.
Open access • 10.1016/j.fsigen.2010.08.005
- Batini, C.; Ferri, G.; Destro-Bisol, G.; Brisighelli, F.; Luiselli, D.; Sanchez-Diz, P.; Rocha, J.; et al. "Signatures of
the Preagricultural Peopling Processes in Sub-Saharan Africa as Revealed by the Phylogeography of Early Y Chromosome Lineages".
Molecular Biology and Evolution 28 9 (2011): 2603-2613. http://dx.doi.org/10.1093/molbev/msr089.
Open access • Published • 10.1093/molbev/msr089
- Berenguer, Alberto; Câmara, Rita A; Brehm, António D; Oliveira, Susana; Fernandes, Ana T. "Distribution of polymorphisms IL4
-590 C/T and IL4 RP2 in the human populations of Madeira, Azores, Portugal, Cape". (2011): http://hdl.handle.net/10400.26/29717.
- Spínola, Carla; Brehm, António; Spínola, Hélder. "Alpha-1-antitrypsin deficiency in the Cape Verde islands (Northwest Africa):
high prevalence in a sub-Saharan population". (2010): http://hdl.handle.net/10400.13/2157.
- Spínola, Carla; Bruges-Armas, Jácome; Pereira, Conceição; Brehm, António; Spínola, Hélder. "Alpha-1-antitrypsin deficiency
in Madeira (Portugal): the highest prevalence in the world". Alpha-1-antitrypsin (AAT) deficiency is a common genetic disease
which affects both lung and liver. Early diagnosis can help asymptomatic patients to adjust their lifestyle choices in order
to reduce the risk of Chronic Obstructive Pulmonary Disease (COPD). The determination of this genetic deficiency prevalence
in Madeira Island (Portugal) population is important to clarify susceptibility and def (2009): http://hdl.handle.net/10400.13/2160.
- Saldanha, Nádia; Spínola, Carla; Santos, Margarida R.; Simões, Joaquim P.; Bruges-Armas, Jácome; Brehm, António; Spínola,
Hélder. "HLA polymorphysms in Forros and Angolares from São Tomé Island (West Africa): evidence for the population origin".
(2009): http://hdl.handle.net/10400.13/31.
- Spínola, C.; Bruges-Armas, J.; Brehm, A.; Spínola, H.. "HLA-A polymorphisms in four ethnic groups from Guinea-Bissau (West
Africa) inferred from sequence-based typing". Tissue Antigens 72 6 (2008): 593-598. http://dx.doi.org/10.1111/j.1399-0039.2008.01147.x.
Open access • 10.1111/j.1399-0039.2008.01147.x
- Prieto, L.; Alonso, A.; Alves, C.; Crespillo, M.; Montesino, M.; Picornell, A.; Brehm, A.; et al. "2006 GEP-ISFG collaborative
exercise on mtDNA: reflections about interpretation, artefacts, and DNA mixtures". Forensic Science International: Genetics
2 2 (2008): 126-133. http://dx.doi.org/10.1016/j.fsigen.2007.10.010.
Open access • 10.1016/j.fsigen.2007.10.010
- Gonçalves, Rita; Parik, Jüri; Freitas, Ana Isabel; Jesus, José; Villems, Richard; Brehm, António. "Identification of endangered
petrel species from poor quality feather debris using cytochrome b sequences". Forensic Science International 174 1
(2008): 87-88. http://dx.doi.org/10.1016/j.forsciint.2006.10.024.
10.1016/j.forsciint.2006.10.024
- Freitas, Ana I.; Mendonça, Isabel; Guerra, Graça; Brión, Maria; Reis, Roberto P.; Carracedo, Angel; Brehm, António. "Methylenetetrahydrofolate
reductase gene, homocysteine and coronary artery disease: The A1298C polymorphism does matter. Inferences from a case study
(Madeira, Portugal)". (2008): http://hdl.handle.net/10400.26/28009.
10.1016/j.thromres.2008.02.005
- Fernandes, A. T.; Rosa, A.; Gonçalves, R.; Jesus, J.; Brehm, A.. "The Y-chromosome short tandem repeats variation within haplogroup
E3b: Evidence of recurrent mutation in SNP". American Journal of Human Biology 20 2 (2008): 185-190. http://dx.doi.org/10.1002/ajhb.20693.
10.1002/ajhb.20693
- Jesus, José; James Harris, D.; Brehm, António. "Relationships of Afroablepharus Greer, 1974 skinks from the Gulf of Guinea
islands based on mitochondrial and nuclear DNA: Patterns of colonization and comments on taxonomy". Molecular Phylogenetics
and Evolution 45 3 (2007): 904-914. http://dx.doi.org/10.1016/j.ympev.2007.08.011.
10.1016/j.ympev.2007.08.011
- Gonçalves, Rita; Spínola, Hélder; Brehm, António. "Y-Chromosome lineages in São Tomé e Príncipe Islands: evidence of european
in¿uence". The Y-chromosome haplogroup composition of the population of Sa ˜ o Tome ´ e Pri ´ ncipe (STP) archipelago was
analyzed using 25 biallelic markers and compared with popula- tions of different origins from Europe, Africa, and the Middle
East. Two main Y-chromosome haplogroups were found: E3a, very common among sub-Saharans accounts for 84.2% of the pa- ternal
lineages and R1b, typical of West Euras (2007): http://hdl.handle.net/10400.13/2147.
- Spínola, Hélder; Bruges-Armas, Jácome; Brehm, António. "Discrepancies in HLA Typing by PCR-SSOP and SBT Techniques: a case
study". Six hundred twenty-one samples from Portugal, the Cabo Verde archipelago, and Guinea-Bissau were typed for HLA-A,
HLA-B, and HLADRB1usingthepolymerasechainreaction–sequence-speci¿coligonucleotide probe (PCR-SSOP) method and the sequence-based
typing (SBT) method to characterizeandcomparediscrepanciesbetweenthetwomethods.Fifty-three alleles (4.27% of 1,242 chromosomes
typed) identi¿ed by the PCR-SS (2007): http://hdl.handle.net/10400.13/1351.
- Rosa, Alexandra; Ornelas, Carolina; Jobling, Mark A; Brehm, António; Villems, Richard. "Y-chromosomal diversity in the population
of Guinea-Bissau: a multiethnic perspective". BMC Evolutionary Biology 7 1 (2007): 124. http://dx.doi.org/10.1186/1471-2148-7-124.
10.1186/1471-2148-7-124
- Gonçalves, Rita; Spínola, Hélder; Brehm, António. "Y-chromosome lineages in São Tomé e Príncipe islands: Evidence of European
influence". American Journal of Human Biology 19 3 (2007): 422-428. http://dx.doi.org/10.1002/ajhb.20604.
10.1002/ajhb.20604
- Crespillo, Manuel; Paredes, Miguel R.; Prieto, Lourdes; Montesino, Marta; Salas, Antonio; Albarran, Cristina; V, Álvarez-Iglesias;
et al. "Results of the 2003–2004 GEP-ISFG collaborative study on mitochondrial DNA: Focus on the mtDNA profile of a mixed
semen-saliva stain". Forensic Science International 160 2-3 (2006): 157-167. http://dx.doi.org/10.1016/j.forsciint.2005.09.005.
10.1016/j.forsciint.2005.09.005
- Fernandes, A. T.. "DAZ gene copies: evidence of Y chromosome evolution". Molecular Human Reproduction 12 8 (2006):
519-523. http://dx.doi.org/10.1093/molehr/gal051.
10.1093/molehr/gal051
- Spínola, Hélder; Bruges-Armas, Jácome; Mora, Marian Gantes; Middleton, Derek; Brehm, António. "HLA genes in Madeira Island
(Portugal) inferred from sequence-based typing: Footprints from different origins". Molecular Immunology 43 10 (2006):
1726-1728. http://dx.doi.org/10.1016/j.molimm.2005.10.001.
10.1016/j.molimm.2005.10.001
- Rosa, Alexandra; Ornelas, Carolina; Brehm, António; Villems, Richard. "Population data on 11 Y-chromosome STRs from Guiné-Bissau".
Forensic Science International 157 2-3 (2006): 210-217. http://dx.doi.org/10.1016/j.forsciint.2005.04.005.
10.1016/j.forsciint.2005.04.005
- Spínola, Hélder; Bruges-Armas, Jácome; Mora, Marian Gantes; Middleton, Derek; Brehm, António. "HLA genes in Madeira Island
(Portugal) inferred from sequence-based typing: footprints from different origins". Human leukocyte antigen (HLA)-A, HLA-B,
and HLA-DRB1 polymorphisms were examined in Madeira Island populations. The data was obtained at high-resolution level, using
sequence-based typing (SBT). The most frequent alleles at each loci were: A*020101 (24.6%), B*5101 (9.7%), B*440201 (9.2%),
and DRB1*070101 (15.7%). The predominant three-loci haplotypes in Madeira were A*020101–B*510101–DRB1*130101 ( (2006):
http://hdl.handle.net/10400.13/2162.
- Freitas, Tamira.; Brehm, António.; Fernandes, Ana Teresa.. "Frequency of the CCR5-¿32 Mutation in the Atlantic Island Populations
of Madeira, the Azores, Cabo Verde, and São Tomé e Príncipe". Human Biology 78 6 (2006): 697-703. http://dx.doi.org/10.1353/hub.2007.0011.
10.1353/hub.2007.0011
- Jesus, José; Harris, D. James; Brehm, António. "Phylogeography of Mabuya maculilabris (Reptilia) from São Tomé Island (Gulf
of Guinea) inferred from mtDNA sequences". Molecular Phylogenetics and Evolution 37 2 (2005): 503-510. http://dx.doi.org/10.1016/j.ympev.2005.04.032.
10.1016/j.ympev.2005.04.032
- Spínola, Hélder; Bruges-Armas, Jácome; Middleton, Derek; Brehm, António. "HLA Polymorphisms in Cabo Verde and Guiné-Bissau
Inferred From Sequence-Based Typing". Human Immunology 66 10 (2005): 1082-1092. http://dx.doi.org/10.1016/j.humimm.2005.09.001.
10.1016/j.humimm.2005.09.001
- Spinola, H.; Brehm, A.; Bettencourt, B.; Middleton, D.; Bruges-Armas, J.. "HLA class I and II polymorphisms in Azores show
different settlements in Oriental and Central islands". Tissue Antigens 66 3 (2005): 217-230. http://dx.doi.org/10.1111/j.1399-0039.2005.00471.x.
10.1111/j.1399-0039.2005.00471.x
- Spinola, H.; Middleton, D.; Brehm, A.. "HLA genes in Portugal inferred from sequence-based typing: in the crossroad between
Europe and Africa". Tissue Antigens 66 1 (2005): 26-36. http://dx.doi.org/10.1111/j.1399-0039.2005.00430.x.
10.1111/j.1399-0039.2005.00430.x
- Gonçalves, Rita; Freitas, Ana; Branco, Marta; Rosa, Alexandra; Fernandes, Ana T.; Zhivotovsky, Lev A.; Underhill, Peter A.;
Kivisild, Toomas; Brehm, António. "Y-chromosome Lineages from Portugal, Madeira and Açores Record Elements of Sephardim and
Berber Ancestry". Annals of Human Genetics 69 4 (2005): 443-454. http://dx.doi.org/10.1111/j.1529-8817.2005.00161.x.
10.1111/j.1529-8817.2005.00161.x
- Martins, N.; Lopes, I.; Brehm, A.; Ribeiro, R.. "Cytochrome B Gene Partial Sequence and RAPD Analysis of Two Daphnia longispina
Lineages Differing in their Resistance to Copper". Bulletin of Environmental Contamination and Toxicology 74 4 (2005):
755-760. http://dx.doi.org/10.1007/s00128-005-0646-7.
10.1007/s00128-005-0646-7
- Jesus, José; Brehm, Antonio; Harris, D. James. "Phylogenetic relationships of Hemidactylus geckos from the Gulf of Guinea
islands: patterns of natural colonizations and anthropogenic introductions estimated from mitochondrial and nuclear DNA sequences".
Molecular Phylogenetics and Evolution 34 3 (2005): 480-485. http://dx.doi.org/10.1016/j.ympev.2004.11.006.
10.1016/j.ympev.2004.11.006
- Salas, Antonio; Prieto, Lourdes; Montesino, Marta; Albarrán, Cristina; Arroyo, Eduardo; Paredes-Herrera, Miguel R.; Di Lonardo,
Ana Ma; et al. "Mitochondrial DNA error prophylaxis: assessing the causes of errors in the GEP’02–03 proficiency testing trial".
Forensic Science International 148 2-3 (2005): 191-198. http://dx.doi.org/10.1016/j.forsciint.2004.06.008.
10.1016/j.forsciint.2004.06.008
- Spínola, Hélder; Bruges-Armas, Jácome; Middleton, Derek; Brehm, António. "HLA polymorphisms in Cabo Verde and Guiné-Bissau
inferred from sequence-based typing". Human leukocyte antigen (HLA)-A, -B, and -DRB1 polymorphisms were examined in the
Cabo Verde and Guiné-Bissau populations. The data were obtained at high-resolution level, using sequence-based typing. The
most frequent alleles in each locus was: A*020101 (16.7% in Guiné-Bissau and 13.5% in Cabo Verde), B*350101 (14.4% in Guiné-Bissau
and 13.2% in Cabo Verde), DRB1*1304 (19.6% in Guiné-Bissau), and (2005): http://hdl.handle.net/10400.13/2163.
- Peixoto, M. J.; Gonzales, T.; Spínola, Hélder; Couto, A. R.; Gantes Mora, M.; Brehm, António; Santos, M. R.; Garrett, F.;
Bruges-Armas, J.. "Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias". A associação da molécula
HLA-B27 com a espondilite anquilosante (AS) e outras espondilartropatias (SpA), permanece como uma das mais fortes verificada
entre moléculas HLA e doenças humanas. Desde que foi descrita, em 1973, tem sido alvo de intensa investigação na tentativa
de compreender o mecanismo patogénico que lhe está subjacente. Este artigo tem como objectivo fazer uma revisão dos conhecimen
(2005): http://hdl.handle.net/10400.13/1352.
- Kivisild, Toomas; Reidla, Maere; Metspalu, Ene; Rosa, Alexandra; Brehm, Antonio; Pennarun, Erwan; Parik, Jüri; et al. "Ethiopian
Mitochondrial DNA Heritage: Tracking Gene Flow Across and Around the Gate of Tears". The American Journal of Human Genetics
75 5 (2004): 752-770. http://dx.doi.org/10.1086/425161.
10.1086/425161
- Rosa, Alexandra; Brehm, Antonio; Kivisild, Toomas; Metspalu, Ene; Villems, Richard. "MtDNA Profile of West Africa Guineans:
Towards a Better Understanding of the Senegambia Region". Annals of Human Genetics 68 4 (2004): 340-352. http://dx.doi.org/10.1046/j.1529-8817.2004.00100.x.
10.1046/j.1529-8817.2004.00100.x
- Rootsi, Siiri; Kivisild, Toomas; Benuzzi, Giorgia; Help, Hela; Bermisheva, Marina; Kutuev, Ildus; Barac, Lovorka; et al. "Phylogeography
of Y-Chromosome Haplogroup I Reveals Distinct Domains of Prehistoric Gene Flow in Europe". The American Journal of Human
Genetics 75 1 (2004): 128-137. http://dx.doi.org/10.1086/422196.
10.1086/422196
- Brehm, António; Harris, D.James; Hernández, Mariano; Perez, José A.; Larruga, José M.; Pinto, Francisco M.; González, Ana
M.. "Phylogeography of Drosophila subobscura from north Atlantic islands inferred from mtDNA A+T rich region sequences". Molecular
Phylogenetics and Evolution 30 3 (2004): 829-834. http://dx.doi.org/10.1016/j.ympev.2003.10.018.
10.1016/j.ympev.2003.10.018
- Isidro, Gl¿ria; Laranjeira, Francisco; Pires, Ana; Leite, J¿lio; Regateiro, Fernando; e Sousa, F. Castro; Soares, Jos¿; et
al. "Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas". Human Mutation 24
4 (2004): 353-354. http://dx.doi.org/10.1002/humu.9282.
10.1002/humu.9282
- Brehm, Ant¿nio; Pereira, Lu¿sa; Kivisild, Toomas; Amorim, Ant¿nio. "Mitochondrial portraits of the Madeira and A¿ores archipelagos
witness different genetic pools of its settlers". Human Genetics 114 1 (2003): 77-86. http://dx.doi.org/10.1007/s00439-003-1024-3.
10.1007/s00439-003-1024-3
- Gon¿alves, Rita; Rosa, Alexandra; Freitas, Ana; Fernandes, Ana; Kivisild, Toomas; Villems, Richard; Brehm, Ant¿nio. "Y-chromosome
lineages in Cabo Verde Islands witness the diverse geographic origin of its first male settlers". Human Genetics 113
6 (2003): 467-472. http://dx.doi.org/10.1007/s00439-003-1007-4.
10.1007/s00439-003-1007-4
- Fernandes, Ana; Brehm, António. "Y-chromosome STR haplotypes in the Açores Archipelago (Portugal)". Forensic Science International
135 3 (2003): 239-242. http://dx.doi.org/10.1016/s0379-0738(03)00202-0.
10.1016/s0379-0738(03)00202-0
- Fernandes, A. T.; Velosa, R.; Jesus, J.; Carracedo, A.; Brehm, A.. "Genetic Differentiation of the Cabo Verde Archipelago
Population Analysed by STR Polymorphisms". Annals of Human Genetics 67 4 (2003): 340-347. http://dx.doi.org/10.1046/j.1469-1809.2003.00029.x.
10.1046/j.1469-1809.2003.00029.x
- González, Ana M.; Brehm, Antonio; Pérez, José A.; Maca-Meyer, Nicole; Flores, Carlos; Cabrera, Vicente M.. "Mitochondrial
DNA affinities at the Atlantic fringe of Europe". American Journal of Physical Anthropology 120 4 (2003): 391-404.
http://dx.doi.org/10.1002/ajpa.10168.
10.1002/ajpa.10168
- Brehm, A.; Jesus, J.; Spi´nola, H.; Alves, C.; Vicente, L.; Harris, D.J.. "Phylogeography of the Madeiran endemic lizard Lacerta
dugesii inferred from mtDNA sequences". Molecular Phylogenetics and Evolution 26 2 (2003): 222-230. http://dx.doi.org/10.1016/s1055-7903(02)00310-x.
10.1016/s1055-7903(02)00310-x
- Brehm, António; James Harris, D.; Alves, Cíntia; Jesus, José; Thomarat, Fabienne; Vicente, Luís. "Structure and Evolution
of the Mitochondrial DNA Complete Control Region in the Lizard Lacerta dugesii (Lacertidae, Sauria)". Journal of Molecular
Evolution 56 1 (2003): 46-53. http://dx.doi.org/10.1007/s00239-002-2379-0.
10.1007/s00239-002-2379-0
- Gonçalves, Rita; Jesus, José; Fernandes, Ana Teresa; Brehm, António. "Genetic profile of a multi-ethnic population from Guiné-Bissau
(west African coast) using the new PowerPlex® 16 System kit". Forensic Science International 129 1 (2002): 78-80. http://dx.doi.org/10.1016/s0379-0738(02)00204-9.
10.1016/s0379-0738(02)00204-9
- Fernandes, Ana Teresa; Brehm, António. "Population data of five STRs in three regions from Portugal". Forensic Science
International 129 1 (2002): 72-74. http://dx.doi.org/10.1016/s0379-0738(02)00202-5.
10.1016/s0379-0738(02)00202-5
- Velosa, Rute Gomes; Fernandes, Ana Teresa; Brehm, António. "Genetic profile of the Açores Archipelago population using the
new PowerPlex®16 System Kit". Forensic Science International 129 1 (2002): 68-71. http://dx.doi.org/10.1016/s0379-0738(02)00203-7.
10.1016/s0379-0738(02)00203-7
- SP??NOLA, H.; BREHM, A.; WILLIAMS, F.; JESUS, J.; MIDDLETON, D.. "Distribution of HLA alleles in Portugal and Cabo Verde.
Relationships with the slave trade route". Annals of Human Genetics 66 4 (2002): 285-296. http://dx.doi.org/10.1017/s0003480002001185.
10.1017/s0003480002001185
- Lepetit, D.; Brehm, A.; Fouillet, P.; Biemont, C.. "Insertion polymorphism of retrotransposable elements in populations of
the insular, endemic species Drosophila madeirensis". Molecular Ecology 11 3 (2002): 347-354. http://dx.doi.org/10.1046/j.1365-294x.2002.01470.x.
10.1046/j.1365-294x.2002.01470.x
- Fernandes, Ana Teresa; Brehm, Antonio ; Alves, Cíntia; Gusmão, Leonor; Amorim, António. "Genetic profile of the Madeira Archipelago
population using the new PowerPlex16 System kit". Forensic Science International 125 2-3 (2002): 281-283. http://dx.doi.org/10.1016/s0379-0738(01)00625-9.
10.1016/s0379-0738(01)00625-9
- BREHM, A.; PEREIRA, L.; BANDELT, H.-J.; PRATA, M. J.; AMORIM, A.. "Mitochondrial portrait of the Cabo Verde archipelago: the
Senegambian outpost of Atlantic slave trade". Annals of Human Genetics 66 1 (2002): 49-60. http://dx.doi.org/10.1017/s0003480001001002.
10.1017/s0003480001001002
- Brehm, A.; Harris, D. J.; Hernández, M.; Cabrera, V. M.; Larruga, J. M.; Pinto, F. M.; González, A. M.. "Structure and evolution
of the mitochondrial DNA complete control region in the Drosophila subobscura subgroup". Insect Molecular Biology 10
6 (2001): 573-578. http://dx.doi.org/10.1046/j.0962-1075.2001.00295.x.
10.1046/j.0962-1075.2001.00295.x
- Brehm, António; Khadem, Mahnaz; Jesus, José; Andrade, Paula; Vicente, Luis. "Lack of congruence between morphometric evolution
and genetic differentiation suggests a recent dispersal and local habitat adaptation of the Madeiran lizard Lacerta dugesii".
Genetics Selection Evolution 33 6 (2001): http://dx.doi.org/10.1186/1297-9686-33-6-671.
10.1186/1297-9686-33-6-671
- BANDELT, H.-J.; ALVES-SILVA, J.; GUIMARAES, P. E. M.; SANTOS, M. S.; BREHM, A.; PEREIRA, L.; COPPA, A.; et al. "Phylogeography
of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave trade". Annals of Human
Genetics 65 6 (2001): 549-563. http://dx.doi.org/10.1046/j.1469-1809.2001.6560549.x.
10.1046/j.1469-1809.2001.6560549.x
- Fernandes, Ana Teresa; Brehm, António; Gusmão, Leonor; Amorim, António. "Y-chromosome STR haplotypes in the Madeira archipelago
population". Forensic Science International 122 2-3 (2001): 178-180. http://dx.doi.org/10.1016/s0379-0738(01)00495-9.
10.1016/s0379-0738(01)00495-9
- Brehm, A; Jesus, J; Pinheiro, M; Harris, D.J. "Relationships of Scincid Lizards (Mabuya spp; Reptilia: Scincidae) from the
Cape Verde Islands Based on Mitochondrial and Nuclear DNA Sequences". Molecular Phylogenetics and Evolution 19 2 (2001):
311-316. http://dx.doi.org/10.1006/mpev.2001.0946.
10.1006/mpev.2001.0946
- Spínola, Hélder; Brehm, António. "Genetic diversity of the Macaronesian leafy liverwort Porella canariensis inferred from
RAPD markers". Plant colonization of the North Atlantic raises the intriguing question of the relationships between extant
island species with their continental counterparts (European, African, and American), which may provide clues to past geographic
distribution and colonization history. It has been suggested that during past glaciations, many plant species with typical
Mediterranean distributions survived in (2001): http://hdl.handle.net/10400.13/1394.
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Drosophila species". Molecular Biology and Evolution 15 12 (1998): 1589-1599. http://dx.doi.org/10.1093/oxfordjournals.molbev.a025887.
10.1093/oxfordjournals.molbev.a025887
- Pinto, F. M.; Brehm, A.; Hernández, M.; Larruga, J. M.; González, A.M.; Cabrera, V. M.. "Population Genetic Structure and
Colonization Sequence of Drosophila subobscura in the Canaries and Madeira Atlantic Islands as Inferred by Autosomal, Sex-Linked
and mtDNA Traits". Journal of Heredity 88 2 (1997): 108-114. http://dx.doi.org/10.1093/oxfordjournals.jhered.a023067.
10.1093/oxfordjournals.jhered.a023067
- Brehm, Antonio; Krimbas, Costas B. "The phylogeny of nine species of the Drosophila obscura group inferred by the banding
homologies of the chromosomal regions. IV. Element C". Heredity 70 2 (1993): 214-220. http://dx.doi.org/10.1038/hdy.1993.31.
10.1038/hdy.1993.31
- Brehm, Antonio; Krimbas, Costas B.. "The phylogeny of nine species of the Drosophila obscura group inferred by the banding
homologies of chromosomal regions. III. Element D". Genome 35 6 (1992): 1075-1085. http://dx.doi.org/10.1139/g92-165.
10.1139/g92-165
- Brehm, Antonio; Krimbas, Costas B.; Sourdis, John; Cariou, Marie-Louise. "The phylogeny of nine species of the Drosophila
obscura group inferred by the banding homologies of chromosomal regions. I. Element B". Genome 34 3 (1991): 464-471.
http://dx.doi.org/10.1139/g91-070.
10.1139/g91-070
- Brehm, A.; Krimbas, C. B.. "Inversion Polymorphism in Drosophila obscura". Journal of Heredity 82 2 (1991): 110-117.
http://dx.doi.org/10.1093/oxfordjournals.jhered.a111044.
10.1093/oxfordjournals.jhered.a111044
- Brehm, A; Krimbas, C B. "Evolution of the obscura group Drosophila species.: III. Phylogenetic relationships in the subobscura
cluster based on homologies of chromosome A". Heredity 65 2 (1990): 269-275. http://dx.doi.org/10.1038/hdy.1990.96.
10.1038/hdy.1990.96
- BREHM, ANTONIO; KRIMBAS, COSTAS B.. "The phylogeny of nine species of the Drosophila obscura group inferred by the banding
homologies of chromosomal regions. II. Element E.". Hereditas 113 2 (1990): 157-168. http://dx.doi.org/10.1111/j.1601-5223.1990.tb00080.x.
10.1111/j.1601-5223.1990.tb00080.x
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