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Daniela Dias-Pedroso has a Bachelor and Masters in Biochemistry from the Faculty of Sciences and Technology, University of Coimbra. From July 2014 to January 2017, Daniela Dias-Pedroso worked as a research fellow in the project "Mechanisms of Cardioprotection by Berries-Driven Polyphenols" (Ref ANR-FCT/BEXBCM/0001/2013), supervised by Helena L.A. Vieira (NMS/CEDOC). The work focused on polyphenols' putative modulation of cell viability, cell beating and Ca2+ signalling in rat neonatal primary cardiomyocytes. During this period, she also participated in a secondary project named "Brain adaptation to hypertension: analysis of hippocampal response in two different chronic rat models of hypertension". Hippocampal neurogenesis was assessed in Dahl Salt-sensitive and Chronic Intermittent Hypoxia-induced hypertension rat models. Daniela Dias-Pedroso developed her doctoral thesis "Carbon Monoxide - Neuroglobin axis on cytoprotection against perinatal cerebral ischemia" at NOVA Medical School, NOVA University of Lisbon, under the supervision of Helena L.A. Vieira (NMS/CEDOC) and Susana S. Lopes (NMS/CEDOC). Her project evaluated the role of neuroglobin-carbon monoxide-induced cytoprotection against inflammation, targeting cellular metabolism. She was also involved in the project "The role of ciliogenesis in carbon-monoxide induced astrocyte cytoprotection", so-supervising a master student in the scope of this work. Daniela Dias-Pedroso has 6 papers published in peer-reviewed journals, 3 of which as co-first author and 2 as first author. She was also co-first author of one conference abstract published in a peer-reviewed journal and accepted for oral communication (performed by Helena L.A Viera) and a author in 2 book chapters. Daniela Dias-Pedroso has two posters as first author accepted and presented by herself in international conferences. Daniela Dias-Pedroso is currently a postdoc at METSY - Institute Gustave Roussy, France. Her work focus on drug resistance in pediatric cancer (osteosarcoma).
Identification

Personal identification

Full name
Daniela Patrícia Martins Dias Pedroso

Citation names

  • Pedroso, Daniela
  • Dias-Pedroso, Daniela

Author identifiers

Ciência ID
3716-1BB9-FCCF
ORCID iD
0000-0002-3407-7394

Email addresses

  • daniela.martins-dias-pedroso@gustaveroussy.fr (Professional)
  • danielapedroso222@gmail.com (Personal)

Addresses

  • Gustave Roussy, PR2, 114 rue Edouard Vaillant, 94805, Villejuif, Paris, France (Professional)

Websites

  • linkedin.com/in/daniela-pmd-pedroso (Social media)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2017/01 - 2021/11/15
Concluded
Mecanismos de Doença e Medicina Regenerativa (associação) (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Carbon Monoxide-Neuroglobin axis on cytoprotection against perinatal cerebral ischemia " (THESIS/DISSERTATION)
2018/03/02 - 2018/03/09
Concluded
Laboratory Animal Science course (Rat/Mouse and Zebrafish) - Function A (FELASA B) (Outros)
Major in Rat/Mouse and Zebrafish - Function A (FELASA B)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2011/08/25 - 2013/09/12
Concluded
Mestrado em Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A Chloroplastidial Atypical Aspartic Protease from Arabidopsis thaliana: Optimization of Heterologous Expression, Purification and Biochemical Characterization" (THESIS/DISSERTATION)
17,3
2008/09/15 - 2011/07/09
Concluded
Licenciatura em Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
15,3
Affiliation

Science

Category
Host institution
Employer
2022/03/01 - Current Postdoc (Research) Institut Gustave Roussy, France
2015 - 2021 Researcher (Research) iNOVA4Health, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2014 - 2015 Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Projects

Contract

Designation Funders
2018/10/01 - 2021/09/30 Pós condicionamento remote isquémico no acidente vascular cerebral: identificação de biomarcadores em circulação novos e estudo clínico para melhorar os resultados clínicos.
PTDC/MEC-NEU/28750/2017
Universidade Nova de Lisboa, Portugal

Centro Hospitalar de Lisboa Ocidental EPE, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2014/02/01 - 2017/01/30 Mechanisms of cardioprotection by Berries Driven Polyphenols
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

INSERM U769, France
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Castanheira, Pedro; Almeida, Carla; Dias-Pedroso, Daniela; Simões, Isaura. "Expression in Escherichia coli, Refolding, and Purification of Plant Aspartic Proteases". In Plant Proteases and Plant Cell Death, edited by Klemencic, Marina; Stael, Simon; Huesgen, Pitter F., 21-33. Springer US, 2022.
    Published • 10.1007/978-1-0716-2079-3_3
  2. Dias-Pedroso, Daniela; Soares, Nuno L; Vieira, Helena L.A.. "Carbon Monoxide and Energy Metabolism". In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, edited by Wang, Binghe; Otterbein, Leo, 88. John Wiley and Sons, NJ, 2022.
    Published
Conference abstract
  1. Dias-Pedroso, Daniela; Vieira, Helena L.A.. "Carbon monoxide-Neuroglobin axis on cytoprotection". Paper presented in XIV European Meeting on Glia Cell in Health and Disease, Porto, 2019.
    Published
  2. Dias-Pedroso, Daniela*; Guerra, Joel*; Gomes, Andreia; Oudot, Carole; Brenner, Catherine; Santos, Cláudia N.; Vieira, Helena L.A.. "Human Bioavailable berries-driven polyphenol metabolites improve cardiomyocytes beating: role of mitochondria, ROS and Ca2+ signalling". Paper presented in 50th Annual Scientific Meeting of the European Society for Clinical Investigation - por Vieira, Helena LA, Paris, 2016.
    Published
Conference poster
  1. Dias-Pedroso, Daniela; Vieira, Helena L.A.. "Carbon monoxide-Neuroglobin axis on cytoprotection". Paper presented in XIV European Meeting on Glia Cell in Health and Disease, 2019.
  2. Dias-Pedroso, Daniela; Vieira, Helena L.A.. "Carbon monoxide-Neuroglobin axis on cytoprotection: modulation of neuroinflammation". Paper presented in 11th FENS Forum of Neuroscience 2018, 2018.
Journal article
  1. Patrício, João S.*; Dias-Pedroso, Daniela*; Carvalho, Rui A.; Viera, Helena L. A.; Jones, John G.. "A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by C NMR isotopomer analysis of the crude lipid fraction". NMR in Biomedicine 35 3 (2021): http://dx.doi.org/10.1002/nbm.4648.
    Published • 10.1002/nbm.4648
  2. Dias-Pedroso, Daniela; Ramalho, José S.; Sardão, Vilma A.; Jones, John G.; Romão, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L.A.. "Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells". Molecular Neurobiology 59 2 (2021): 916-931. http://dx.doi.org/10.1007/s12035-021-02630-4.
    Published • 10.1007/s12035-021-02630-4
  3. Figueiredo-Pereira, Cláudia*; Dias-Pedroso, Daniela*; Soares, Nuno L.; Vieira, Helena L.A.. "CO-mediated cytoprotection is dependent on cell metabolism modulation". Redox Biology 32 (2020): 101470. http://dx.doi.org/10.1016/j.redox.2020.101470.
    Published • 10.1016/j.redox.2020.101470
  4. Dias-Pedroso, Daniela; Guerra, Joel; Gomes, Andreia; Oudot, Carole; Brenner, Catherine; Santos, Cláudia N.; Vieira, Helena L.A.. "Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol". Cardiovascular Toxicology 19 2 (2019): 156-167. https://doi.org/10.1007/s12012-018-9485-8.
    Published • 10.1007/s12012-018-9485-8
  5. Santos, Claudia N.; Gomes, Andreia; Oudot, Carole; Dias-Pedroso, Daniela; Rodriguez-Mateos, Ana; Vieira, Helena L.A.; Brenner, Catherine. "Pure Polyphenols Applications for Cardiac Health and Disease". Current Pharmaceutical Design 24 19 (2018): 2137-2156. http://dx.doi.org/10.2174/1381612824666180608102344.
    Published • 10.2174/1381612824666180608102344
  6. Pedroso, Daniela *; Nunes, Ana R*; Diogo, Lucília N.; Oudot, Carole; Monteiro, Emília C.; Brenner, Catherine; Vieira, Helena L.A.. "Hippocampal neurogenesis response: What can we expect from two different models of hypertension?". Brain Research 1646 (2016): 199-206. http://dx.doi.org/10.1016/j.brainres.2016.05.044.
    Published • 10.1016/j.brainres.2016.05.044
Thesis / Dissertation
  1. Pedroso, Daniela Patrícia Martins Dias. "A Chloroplastidial Atypical Aspartic Protease from Arabidopsis thaliana: Optimization of Heterologous Expression, Purification and Biochemical Characterization". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2013. http://hdl.handle.net/10316/24664.
Activities

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019/07/10 - 2019/07/13 XIV European Meeting on Glia Cell in Health and Disease, Porto, Portugal
Conference
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Network Glia, Germany
2019/04/01 - 2019/04/02 Synaptic Function, Dysfunction and Repair
Symposium
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/03/12 - 2019/03/12 Statistics Applied to Clinical Research
Workshop
CUF Academic and Research Medical Center, Portugal
2018/11/07 - 2018/11/08 Rodent Necropsy
Workshop
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018/07/07 - 2018/07/11 11th FENS Forum of Neuroscience, Berlin, Germany
Conference
Federation of European Neuroscience Societies, Belgium
2018/04/21 - 2018/04/28 Design Thinking
Workshop
NOVA Doctoral School, Portugal

Universidade Nova de Lisboa, Portugal
2017/05/08 - 2017/05/09 First Joint WG4-WG5 Transautophagy Translational Workshop
Workshop
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017/03/17 - 2017/03/17 iNOVA4Health Symposium on Inflammation
Symposium
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2015/04/20 - 2015/10/24 Flow Cytometry: Fundamentals and Applications
Workshop
Instituto Gulbenkian de Ciência, Portugal
2015/10/05 - 2015/10/09 Quantitative Fluorescence Microscopy
Workshop
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/02/23 - 2015/02/27 Cardiovascular Sciences
Workshop
Universidade de Coimbra Faculdade de Medicina, Portugal