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I am an Invited Assistant Professor (full time) at Instituto Universitário de Ciências da Saúde CESPU and an Associate Researcher at the Cancer Drug Resistance (CDR) Group at i3S, Portugal. I am a Managing Committee member (representing Portugal) of the COST Action CA21116 (2023-2027). I hold an H-index of 17 with 36 publications (23 in the last 4-years), being 1st author in 12 papers and last or corresponding author in 5 papers. In 2006, I graduated in Applied Biology at Univ.Minho (UM), Portugal. In 2012, I completed an European PhD in Health Sciences (4-years FCT grant) at UM, in collaboration with the Institute of Cancer Biology (Denmark) dedicated to identify novel compounds/combinations to improve cancer therapy. In 2012, I moved to UK for a 3-year Postdoc contract at Division of Cancer Therapeutics, Institute of Cancer Research (ICR). My main project aimed to identify novel genes crucial in pancreatic cancer, by performing a high throughput screening of a panel of cell lines. Promising results obtained prompted new research projects inside the group. I was also involved in multidisciplinary Drug Discovery Projects by performing preclinical studies that led to the enrollment of 2 small molecules into Phase 1 clinical trials. I also generated pancreatic cancer cells resistant to a drug to test “in house” small molecules. In 2015, back to Portugal, I joined CDR at i3S, led by Prof. Helena Vasconcelos. I was selected by the same group for a Postdoc Grant (1 year, 2016) within a funded project to study the contribution of Extracellular Vesicles (EVs) to cancer drug resistance. In 2017, I was awarded with an Individual FCT Postdoc Grant (2017-2023), in the same group, to understand the contribution of macrophage-secreted EVs to drug resistance in pancreatic cancer. This work, in collaboration with IPO-Porto, was published in Cancer Letters, 2021 (PMID: 33212158) as 1º author, giving rise to a new line of research in the group. I am also involved in other related projects to identify novel compounds/drug combinations to counteract cancer drug resistance. In 2021, I received a financial stimulus to lead a “Beacon Project” in the framework of Porto Comprehensive Cancer Center. I am establishing strong international collaborations as a member of 3 COST Actions: CA21135: “Modelling immunotherapy response and toxicity in cancer” (2022-2026); CA21116: “Identification of biological markers for prevention and translational medicine in pancreatic cancer”(2022-2026) and CA17104: “New diagnostic and therapeutic tools against multidrug resistant tumors” (2018-2022). I am supervising 5 PhD (ongoing) and 11 MSc (1 ongoing) students, and 10 (1 ongoing) students doing master/course degree. I was involved in teaching activities, giving practical classes as Invited Assistant at Faculty of Pharmacy, University of Porto, in 2021 and 2023 (6 months) and as an Invited Professor at Dep. of Biology-UM in 2022 and 2023 (6 months). I was a Guest Editor of 3 Special Issues: “Drug Repurposing for Cancer Therapies” (IJMS), “Targeting the tumor microenvironment for cancer treatment” (JMCM) and “Bioactive Molecules as Multidrug Resistance Modulators" (Molecules). I am on the Reviewer Board of IJMS, Molecules, JMCM and Cancer Treatment and Research Communication. I reviewed more than 50 papers for international journals. I am a Science Ambassador for EACR and i3S. I am an EORTC member. I am involved in Science dissemination for undergraduate students through CiênciaViva. I am involved in writing funded competitive projects, in organizing and as scientific committee of national and international meetings. I have been invited as jury member of doctoral and master thesis, and as an evaluator of national and international research projects.
Identification

Personal identification

Full name
Cristina Pinto Ribeiro Xavier
Date of birth
1983/10/27
Gender
Female

Citation names

  • Xavier, Cristina PR

Author identifiers

Ciência ID
3814-A68B-E3B3
ORCID iD
0000-0002-4613-1917

Email addresses

  • cristinax@ipatimup.pt (Professional)
  • crisprxavier@gmail.com (Personal)

Addresses

  • Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)