Identification
Personal identification
- Full name
- Francisca Lopes
Citation names
- Lopes, Francisca
Author identifiers
- Ciência ID
- 3911-17F9-540E
- ORCID iD
- 0000-0002-5350-147X
Telephones
- Telephone
-
- 217946400 (Personal)
Addresses
- Faculdade de Farmácia da Universidade de Lisboa. Av Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)
Knowledge fields
- Exact Sciences - Chemical Sciences - Organic Chemistry
- Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
- Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Education
Degree | Classification | |
---|---|---|
2016/06
Concluded
|
Medicinal Chemistry (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
|
2000
Concluded
|
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Potenciais Pró-fármacos de sulfonamidas. Reactividade química e enzimática" (THESIS/DISSERTATION)
|
Muito Bom com Distinção e louvor |
1986
Concluded
|
Pharmaceutical Sciences (Licenciatura)
Universidade de Lisboa, Portugal
"Potenciais Pró-fármacos de Sulfonamidas : Reactividade Química e Enzimática" (THESIS/DISSERTATION)
|
Affiliation
Teaching in Higher Education
Category Host institution |
Employer | |
---|---|---|
2012/07 - Current | Associate Professor (University Teacher) | Universidade de Lisboa Faculdade de Farmácia, Portugal |
2000/04 - 2012/07 | Assistant Professor (University Teacher) | Universidade de Lisboa Faculdade de Farmácia, Portugal |
1990/10 - 2000/04 | Assistant (University Teacher) | Universidade de Lisboa Faculdade de Farmácia, Portugal |
1986/04/30 - 1990/10/17 | Trainee Assistant (University Teacher) | Universidade de Lisboa Faculdade de Farmácia, Portugal |
Projects
Contract
Designation | Funders | |
---|---|---|
2022/10/27 - Current | Iron-triggered technologies as a novel targeted therapy for cancer
LCF/TR/CI22/52660003
Researcher
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
|
Fundação 'la Caixa'
Ongoing
|
2023 - 2026 | Ferrous Iron-Activable Drug Conjugates: Targeting Iron Metabolism in the Era of Precision Oncology
2022.07857.PTDC
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018/10/01 - 2021/09/30 | A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC/MED-QUI/30021/2017
Researcher
Universidade Nova de Lisboa, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal |
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018 - 2021 | Target@TB. Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
PTDC/MED-FAR/30266/2017
Principal investigator
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2012/03/01 - 2015/08/31 | Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle
PTDC/SAU-FAR/118459/2010
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal |
Fundação para a Ciência e a Tecnologia Stichting Weten Concluded
|
2010/04 - 2013/09 | New drugs for treating and eradicating malaria
HMSP-CT/SAU-ICT/0068/2009
Researcher
Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal Fundação Calouste Gulbenkian, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal |
Stichting Weten Fundação para a Ciência e a Tecnologia Concluded
|
2010/01 - 2013/06 | Targeting the mitochondrial electron transport chain of malaria parasites: computer-assisted design and synthesis of bc1 complex
inhibitors as antimalarial agents
PTDC/SAU-FCF/098734/2008
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
Stichting Weten Fundação para a Ciência e a Tecnologia Concluded
|
2007 - 2010 | Recycling antimalarials: rational design of novel 8-aminoquinoline analogues with gametocytocidal and blood-schizontocidal
activity
PTDC/QUI/65142/2006
Researcher
Universidade do Porto Centro de Investigação em Química, Portugal
|
Concluded
|
2002 - 2005 | A new approach to antimalarial therapy. Novel chemical delivery systems for primaquine and amodiaquine
POCTI/FCB/39218/2001
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
Concluded
|
Outputs
Publications
Book chapter |
|
Journal article |
|
Intellectual property
Patent |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2024/01/24 | Uncovering novel chemotypes targeting the mycobacterial energy metabolism as a strategy to control tuberculosis | 15th National Organic Chemistry Meeting (15ENQO) and the 8th National Medicinal Chemistry Meeting (8ENQT)
SPQ (Faro, Portugal)
|
2022/04/01 | Lead optimization of azaaurones as novel chemotypes against Mycobacterium tuberculosis | 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting -
SPQ (Lisboa, Portugal)
|
2020/01 | Discovery and optimization of new compounds active against multi-drug resistant M. tuberculosis | II Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal
FFUL (Lisboa, Portugal)
|
2019/11 | Discovery of azaaurones as potent antimycobacterial agents | XXV Encontro Galego-Português de Química
Colegio Oficial de Químicos de Galicia (Santiago de Compostela, Spain)
|
2019/03 | Novos Fármacos para a Tuberculose | I Simpósio Dia Mundial da Tuberculose
FFUL/SPP/SPDIMC (Lisboa, Portugal)
|
2016/06 | A chemical drug delivery approach to improve antimalarial activity | Parasitic Infections
Euro Sci Con (London, United Kingdom)
|
2016 | Nanoencapsulation of tetraoxane-based double drugs with antileishamanial activity | 3rd COST Action CM1307 Conference
(Madrid, Spain)
|
2014 | Stuctural optimization of multi-stage acting endoperoxide-based hybrid antimalarials | COST Action CM1307 Join Event
(Calvi, France)
|
2012 | Dual-stage acting antimalarials | Medicinal Chemistry and Malaria Workshop
(Lisboa, Portugal)
|
2012 | Peroxide-based hybrid drugs: synthesis and antimalarial evaluation | Organic and Medicinal Chemistry Workshop
(Lisboa, Portugal)
|
2009 | Artemisinin-falcipain inhibitor hybrid molecules: a new approach to dual acting antimalarial | 2º Encontro da Plataforma Ibérica da Malária
GSK, Tres Cantos (Madrid, Spain)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2023/11/01 - Current | Development of chemical tools to profile the target engagement of nitro 5-membered ring heterocycles against Mycobacterium
tuberculosis
Supervisor
|
Ciências Farmacêuticas (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2023/11/01 - Current | A multi targeting approach to tackle latency in tuberculosis
Supervisor
|
Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2023/10/01 - Current | Structural optimization of hybrid quinolinimine to target the mycobacterial energy metabolism
Supervisor
|
Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2022 - Current | Otimização Estrutural de quinoloniminas para atuação ao nível do metabolismo energético do Micobcterium tuberculosis
Supervisor
|
Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2022 - Current | The energetic metabolism of Mycobacterium tuberculosis as a target for the development of anti-tuberculosis drugs: new and
promising approaches
Co-supervisor
|
Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2018 - Current | Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron
Co-supervisor
|
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2017 - Current | Development of new drug leads for tuberculosis
Supervisor
|
Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2020/11 - 2024/11 | Targeting the energy metabolism of Mycobacterium tuberculosis
Supervisor
|
Pharmacy, Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2021/10/22 - 2022/12 | Smart hydrid compounds to target the respiratory electron transport chain (ETC) of Mycobacterium tuberculosis
Supervisor
|
Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2020/11 - 2021/11 | Desenvolvimento de moléculas híbridas tendo como alvo a cadeia respiratória do Mycobacterium tuberculosis
Supervisor
|
Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2019 - 2021/05 | Development of artemisinin-vinyl sulfone hybrid drugs with potential antitumoral activity
Supervisor
|
Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2018 - 2020 | Hit optimization to improve aqueous solubility of compounds with antimycobacterial activity
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2018 - 2019 | Development of new neutrophil elastase inhibitors for topical formulation with improved therapeutic efficacy
Supervisor
|
Mestrado de Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2017 - 2019 | Desenvolvimento de fármacos híbridos antitumorais direccionados para o lisossoma
Co-supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2015/09 - 2018/12 | Chemical Interrogation of the protein cysteinome of malaria liver stage: from covalent inhibitors to bioorthogonal clickable
probes
Posdoctoral researcher
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2017 - 2017 | Synthesis and identification of tetraoxane-based hybrid compounds as antileishmanials
Co-supervisor
|
Universiteit Antwerpen Departement Farmaceutische Wetenschappen, Belgium
|
2016 - 2017 | Inducing oxidative stress in parasites: novel hybrid compounds based on peroxides to trap catalytic cysteine residues
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2016 - 2016 | Tetraoxanes as Chemical Drug Delivery Systems
Co-supervisor
|
|
2015 - 2016 | Nanoencapsulation of New Compounds with Potential Anti-Leismanial Activity
Co-supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2014 - 2016 | Optimização de Compostos de Quinolina para Doenças Negligenciadas. Bloqueio de Vias de Metabolização
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2013/01 - 2014/10 | A mass spectrometry approach to unravel the metabolic pathways of antimalarial hybrid compounds.
Postdoctoral researcher
Co-supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2013 - 2014 | Synthesis and characterization of a hybrid compound with potential antimalarial activity
Co-supervisor
|
Erasmus. University Liège (Master) |
2010 - 2014 | Peroxide-based hybrid and prodrug antimalarials to deliver cysteine protease inhibitors into the parasitic food vacuole
Co-supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2012 - 2013 | Síntese de novos compostos híbridos com atividade antimalárica
Supervisor
|
|
2011 - 2012 | Development of hybrid antimalarial compounds with peroxide and 8-aminoquinoline pharmacophores as candidates for malaria erradication
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2007 - 2012 | Compostos Híbridos da Artemisinina. Direccionamento para as fases sanguínea e hepática do parasita da malária
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2006 - 2010 | Novel Mitochondrial Electron Transport-Chain Inhibitors as Potential Antimalarial Agents
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2005 - 2006 |
Síntese e avaliação de derivados da amodiaquina
Supervisor
|
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2024/02/05 | Combining synthesis inspired in natural products and nanotechnology: a rational strategy to treat biofilm infections
(Thesis) Main arguer
|
Daniela Loureiro (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
|
2023/12/21 | Temporospatial Tuned Protein Degradation Using Light-Controllable PROteolysis-TArgeting Chimeras (PROTACS)
(Thesis) Arguer
|
Anastasiya Voloshchuk (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2023/04/26 | Flavones, Chalcones and Diarylpentanoids as Antitumor Agents: Discovery, Optimization and Structure-activity Relationship
Studies
(Thesis) Main arguer
|
Joana Moreira (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
|
2023/02/01 | Target-based and Phenotypic Studies towards the Discovery of Antimicrobial Adjuvants
(Thesis) Main arguer
|
Fernando André Pereira Marques Durães (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
|
2022/11/02 | PREPARATION AND BIOLOGICAL EVALUATION OF NEW TRITERPENOID DERIVATIVES OF GLYCYRRHETINIC ACID
(Thesis) Main arguer
|
Daniela Pereira Santana Alho (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2022 | Desenvolvimento de novos inibidores da necroptose direcionados à RIP1
(Thesis) Arguer
|
Beatriz Chaves Cambaio (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2022 | Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron
Supervisor
|
Diogo Maria Trindade Fonseca Magalhães e Silva (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2021/10/06 | Synthesis and neuroprotection studies of new xanthenes and fluorenes
(Thesis) Main arguer
|
Márcia Sofia Silva Martins (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
|
2021/06/29 | Genetic determinants of malaria therapeutics’ cross resistance with novel compounds
(Thesis) Arguer
|
Carla Sofia Martins Calçada (PhD)
Universidade do Minho Escola de Medicina, Portugal
|
2021/04/09 | Síntese e Avaliação Biológica de Novos Compostos Antitumorais Derivados de Triazenos
(Thesis) Main arguer
|
Catarina Teixeira António (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2020/12 | Preparation and Preclinical Evaluation of New Ursane-type Triterpenoids
(Thesis) Main arguer
|
Ana Sofia de Castro Valdeira (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2020/06/03 | Hit optimization to improve aqueous solubility of compounds with antimycobacterial
activity
Supervisor
|
Elisabete Cristina Silva Freitas (Master) |
2017/12 | Doutoramento
(Thesis) Main arguer
|
Sandra Antónia Cordeiro Figueiredo (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2014/07 | Doutoramento
(Thesis) Main arguer
|
Francesco Montalbano (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2014 | Doutoramento
(Thesis) Arguer
|
Marta Andreia Pais Carrasco (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2013 | Doutoramento
(Thesis) Arguer
|
Catarina Alexandra Batista Rodrigues (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2012/07 | Doutoramento
Supervisor
|
Rita Sofia Salvador Simões Capela (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2010/12 | Doutoramento
Supervisor
|
Tiago Correia de Oliveira Rodrigues (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2010/11 | Doutoramento
(Thesis) Arguer
|
João Paulo Martins Ferreira Lavrado (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2009/07 | Doutoramento
(Thesis) Arguer
|
Célia Maria Cardona Faustino (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2007/10 | Doutoramento
(Thesis) Arguer
|
Ana Júlia Pinto Fonseca Seuve Afonso Rodrigues (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
|
2007 | Doutoramento
(Thesis) Arguer
|
Luísa Cristina Dias Martins (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
2006/05 | Doutoramento
(Thesis) Main arguer
|
Daniel André Botelho da Silva (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
2005/02 | Doutoramento
(Thesis) Arguer
|
Ana Paula Gameiro Francisco (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
|
Interview (newspaper / magazine)
Activity description | Newspaper / Forum | |
---|---|---|
2019/05 | The topic of the interview was the challenges that tuberculosis drug discovery faces today. In addition, the development of new compounds for tuberculosis active against multi-resistant tuberculosis through the research project funded by FCT and developed in the Faculty of Pharmacy, was also adressed. | News Farma Revista SIDA |
Mentoring / Tutoring
Topic | Student name | |
---|---|---|
2016 - 2027 | Design synthesis and biological evaluation of new antiplasmodial compounds related to ellagic acid | Bernardo Santos Brasil |
2016 - 2017 | Analogues of the Antimicrobial Peptide BP214 | Catarina Rainho Coelho |
2016 - 2017 | Tuberculose: Tratamento atual e novos fármacos em estudo | Joana Brígida Fonseca Luís |
2016 - 2017 | Malária. Tratamento e Prevenção. Consulta do viajante. | Nikolay Nikolaev Tomov |
Distinctions
Other distinction
2015 | Sabbatical fellowship for a research visit to the Molecular Mycobacteriology Research Unit and Drug Discovery and Development Centre , University of Cape Town |
1997 | Fellowship to attend the Winter School on Organic Reactivity (WISOR VI), Bressanone. |
1987 | Fellowship for a research visit to the MD Anderson Hospital Texas University |