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Miguel Rocha Vaz Pinto. Concluiu o(a) Mestrado em Bioquímica em 2018 pelo(a) Universidade do Porto Faculdade de Ciências e Licenciatura em Licenciatura em Biologia em 2014/07/03 pelo(a) Universidade de Aveiro. Publicou 3 artigos em revistas especializadas. Possui 1 capítulo(s) de livros. Participou em 3 evento(s). Coorientou 1 trabalho(s) de conclusão de curso de licenciatura/bacharelato. Participa e/ou participou como Bolseiro de Investigação em 1 projeto(s) e Investigador em 2 projeto(s). Atua na(s) área(s) de Ciências da Engenharia e Tecnologias com ênfase em Nanotecnologia com ênfase em Nanomateriais, Ciências Exatas com ênfase em Química com ênfase em Química Orgânica, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Bioquímica, Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Farmacologia e Farmácia e Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Química Médica. Nas suas atividades profissionais interagiu com 27 colaborador(es) em coautorias de trabalhos científicos.
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Identification

Personal identification

Full name
Miguel Rocha Vaz Pinto

Citation names

  • Pinto, Miguel

Author identifiers

Ciência ID
3916-9838-79C6
ORCID iD
0000-0002-9031-4577
AuthenticusID
R-00H-KYC
Scopus Author Id
57202110995

Knowledge fields

  • Engineering and Technology - Nano-technology - Nano-materials
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2019/12/02 - 2023/11/30
Ongoing
 Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2015/09/01 - 2017/12/11
Concluded
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Development of effective PEGylated PCL-based nanoformulations for the delivery of potent MAO-B chromone–based inhibitors." (THESIS/DISSERTATION)
 16
2011/09 - 2014/07/03
Concluded
 Licenciatura em Biologia (Licenciatura)
Universidade de Aveiro, Portugal
"Estudo das condições de crescimento bacteriano para a otimização da produção de biossurfactantes" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2019/12/01 - Current Researcher (Research) Universidade do Porto Centro de Investigação em Química, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2018/02/15 - 2019/05/31 Contracted Researcher (Research) Universidade do Porto Centro de Investigação em Química, Portugal
Projects

Contract

Designation Funders
2018/07/26 - 2022/05/25 Desenvolvimento de inibidores da catecol O-metiltransferase de acção central sem risco de hepatotoxicidade
PTDC/MED-QUI/29164/2017
Universidade do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Centro de Investigação em Química da Universidade do Porto (Chemistry Research Center of the University of Porto)
UID/QUI/00081/2019
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/02/01 - 2019/05/31 Sustainable Advanced Materials (SAM)
Norte-01-0145-FEDER-000028
Research Fellow
Universidade do Porto Centro de Investigação em Química, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded

Other

Designation Funders
2019/01/01 - 2019/11/30 ABFish - Development of new antibiotics for aquaculture
POCI-01-0145-FEDER-028397
Researcher
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/11/30 COMT4BRAIN - Development of centrally-active and safe catechol O-methyltransferase inhibitors
POCI-01-0145-FEDER-029164
Researcher
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Pinto, Miguel; Benfeito, Sofia; Fernandes, Carlos; Borges, Fernanda. "Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants". In Oxidative Stress and Dietary Antioxidants in Neurological Diseases, edited by Victor R. Preedy; Colin Martin, 125-141. San Diego, United States: Elsevier, 2020.
    10.1016/b978-0-12-817780-8.00009-8
  2. Silva, Cátia; Pinto, Miguel; Fernandes, Carlos; Benfeito, Sofia; Borges, Fernanda. "Antioxidant Therapy and Neurodegenerative Disorders: Lessons From Clinical Trials". In Reference Module in Biomedical Sciences. Elsevier, 2020.
    10.1016/b978-0-12-801238-3.11611-3
Conference poster
  1. Cláudia Sofia Machado; Pinto, Miguel; Brandon Aguiar; Borges, Fernanda; Carlos Fernandes. "Nanostructured Lipid Carriers as vectors for entacapone brain targeting". Paper presented in Encontro Ciência 2024, 2024.
  2. Cláudia Sofia Machado; Pinto, Miguel; Fernanda Borges; Carlos Fernandes. "Development of polymeric nanocarriers for entacapone encapsulation". Paper presented in XXVII Encontro Luso-Galego de Química, 2023.
  3. Pinto, Miguel; Cláudia Sofia Machado; Barreiro, Sandra; Remião, Fernando; Otero-Espinar, Francisco ; Borges, Fernanda; Fernandes, Carlos. "Polymeric and lipidic-based nanocarriers to reduce tolcapone hepatotoxicity.". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, 2023.
  4. Alfenim, Ana Rita; Brandon Aguiar; Pinto, Miguel; Fernanda Borges; Carlos Fernandes. "Design and optimization of Edaravone loaded PLGA-based nanoparticles". Paper presented in XVI Encontro de Jovens Investigadores da UP (IJUP23), 2023.
  5. Pinto, Miguel; Barreiro, Sandra. "Rescuing a troubled tolcapone: nanomedicine on hepatotoxicity fight club.". Paper presented in 56th Congress of the European Societies of Toxicology (EUROTOX 2021), 2021.
  6. Pinto, Miguel; Fernandes, Carlos; Gil-Martins, Eva; Silva, Renata; Benfeito, Sofia; Cagide, Fernando; Borges, Fernanda; Remião, Fernando. "Bioavailability improvement of a monoamine oxidase-B inhibitor using PEGylated PCL-based nanoparticles". Paper presented in 55th Congress of the European Societies of Toxicology (EUROTOX 2019), 2019.
  7. Pinto, Miguel; Fernandes, Carlos; Borges, Fernanda. "Development of chitosan/PEG hybrid coated PLGA nanoparticles to improve entacapone therapeutic efficacy". Paper presented in NanoMed Europe 2019, 2019.
  8. Pinto, Miguel; Soares, Carlos; Fernandes, Carlos; Borges, Fernada. "De-risking tolcapone hepatotoxicity for repurposing therapy using a nanotechnological approach". Paper presented in Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting 2019, 2019.
  9. Pinto, M.; Fernandes, C.; Borges, F.. "Design and development of novel ammonium cations-functionalized PLGA nanocarriers for targeted drug delivery to central nervous system.". Paper presented in 3rd WG meeting of the MuTaLig COST Action CA15135, Valletta, Malta, 18 th -19 th October, 2018., 2018.
  10. Pinto, M.; Fernandes, C.; Reis, J.; Martins, E.; Silva, R.; Lúcio, M.; Remião, F.; Garrido, J.; Borges, F.. "Enhancing the bioavailability properties of a potent monoamine oxidase-B inhibitor using a nanotechnological approach.". Paper presented in 2nd WG meeting of the MuTaLig COST Action CA15135, Tenerife, Spain, 15 th -17 th March, 2018., 2018.
  11. Pinto, M.; Fernandes, C.; Reis, J.; Lúcio, M.; Remião, F.; Garrido, J.; Borges, F.. "Development of an effective PCL/PEG nanoparticle-based system to deliver a potent MAO-B chromone–based inhibitor across blood-brain barrier.". Paper presented in VII Meeting of the Paul Ehrlich Euro-PhD Network, Vienna, Austria, 25 th -27 th August, 2017., 2017.
  12. Pinto, M.; Fernandes, C.; Reis, J.; Nunes, R.; Sarmento, B.; Remião, F.; Borges, F.. "Development of PEGylated polycaprolactone based nanoformulations to improve the bioavailability properties of novel MAO-B inhibitors.". Paper presented in 10 th Meeting of Young Researchers (IJUP), University of Porto,, 2017.
Journal article
  1. Miguel Pinto; Tiago Barros Silva; Vilma A. Sardão; Rui Simões; Bárbara Albuquerque; Paulo J. Oliveira; Maria João Valente; et al. "Cellular and Mitochondrial Toxicity of Tolcapone, Entacapone, and New Nitrocatechol Derivatives". ACS Pharmacology & Translational Science 7 5 (2024): 1637–1649-1637–1649. http://dx.doi.org/10.1021/acsptsci.4c00124.
    10.1021/acsptsci.4c00124
  2. Pinto, Miguel; Machado, Cláudia Sofia; Barreiro, Sandra; Otero-Espinar, Francisco J.; Remião, Fernando; Borges, Fernanda; Fernandes, Carlos. "Rescuing a Troubled Tolcapone with PEGylated PLGA Nanoparticles: Design, Characterization, and Hepatotoxicity Evaluation". ACS Applied Materials & Interfaces 16 17 (2024): 21522-21533. http://dx.doi.org/10.1021/acsami.4c00614.
    10.1021/acsami.4c00614
  3. Miguel Pinto; Vera Silva; Sandra Barreiro; Renata Silva; Fernando Remião; Fernanda Borges; Carlos Fernandes. "Brain Drug Delivery and Neurodegenerative Diseases: Polymeric PLGA-Based Nanoparticles as a Forefront Platform". Ageing Research Reviews (2022):
    10.1016/j.arr.2022.101658
  4. Jéssica S. Barbosa; Miguel Pinto; Sandra Barreiro; Carlos Fernandes; Ricardo F. Mendes; Pedro Lavrador; Vítor M. Gaspar; et al. "Coordination Compounds As Multi-Delivery Systems for Osteoporosis". ACS Applied Materials & Interfaces (2021): https://doi.org/10.1021%2Facsami.1c09121.
    10.1021/acsami.1c09121
  5. Miguel Pinto; Carlos Fernandes; Eva Martins; Renata Silva; Sofia Benfeito; Fernando Cagide; Ricardo F. Mendes; et al. "Boosting Drug Discovery for Parkinson’s: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles". Pharmaceutics 11 7 (2019): 331-331. https://doi.org/10.3390%2Fpharmaceutics11070331.
    10.3390/pharmaceutics11070331
  6. Daniel Chavarria; Fernando Cagide; Miguel Pinto; Lígia R. Gomes; John N. Low; Fernanda Borges. "Development of piperic acid-based monoamine oxidase inhibitors: Synthesis, structural characterization and biological evaluation". Journal of Molecular Structure 1182 (2019): 298-307. https://doi.org/10.1016%2Fj.molstruc.2019.01.060.
    10.1016/j.molstruc.2019.01.060
  7. Fernandes, C.; Pinto, M.; Martins, C.; Gomes, M.J.; Sarmento, B.; Oliveira, P.J.; Remião, F.; Borges, F.. "Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier". Bioconjugate Chemistry 29 5 (2018): 1677-1689. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047195982&partnerID=MN8TOARS.
    10.1021/acs.bioconjchem.8b00151
Thesis / Dissertation
  1. Pinto, Miguel. "Development of effective PEGylated PCL-based nanoformulations for the delivery of potent MAO-B chromone–based inhibitors.". Master, Universidade do Porto Faculdade de Ciências, 2017.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/05/10 Development of polymeric nanoparticles to ameliorate catechol O-methyltransferase Inhibitor induced hepatotoxicity Encontro Nacional de jovens investigadores da UP (IJUP23)
Universidade do Porto (Porto, Portugal)
2021/02/18 Overcoming tolcapone hepatotoxicity: a nanomedicine-based approach SPF Meeting 2021
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/07/14 Development of a PEGylated-based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier VIII Meeting of the Paul Ehrlich Euro-PhD Network, Porto, Portugal, 12-14 th July 2018.
Paul Ehrlich MedChem Euro-PhD Network (Porto, Portugal)
2018/02/07 Nanotechnology breakthrough in neurodegenerative diseases: a new route for the bioavailability improvement of a potent and reversible MAO-B inhibitor. 11 th Meeting of Young Researchers (IJUP), University of Porto, Porto, Portugal, 7 th -9 th February, 2018.
University of Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/12/01 - 2019/07/01 Design and Development of Cationic Nanoparticles for the Delivery of a Catechol O-Methyltransferase Inhibitor into the Brain.
Co-supervisor of Carlos Daniel Vilaça Sousa Soares
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/10/19 - 2021/10/22 Novel challenges in Toxicology is an innovative PhD Advanced course that provides an updated overview of key toxicological concepts and milestones, and also simultaneously addresses the new challenges and opportunities of modern Toxicology. This course is offered to the students enrolled in the PhD programme in Pharmacy (FFUL) that need to complement their background in different aspects of the Toxicological Sciences and/or need to use toxicological tools to complete their PhD work plan. Final Classification: 17/20
Workshop
 Novel challenges in Toxicology – PhD Advanced Course
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/03/18 - 2021/03/20 The aim of this Course is to disseminate throughout the scientific and professional community the state-of-the-art concepts about the blood-brain barrier, namely its relevance as an obstacle for treatment of brain disorders and the strategies that have been used for drug delivery to the brain, as well as the models and tools that can be used for its study.
Workshop
 Models of the Blood-Brain Barrier: Scientific Tools to Target the Brain
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/03/06 - 2019/03/08 The third MuTaLig Training School, entitled “CA15135 multi-targeting Biophysical Training School”, was organized in order to identify young talented researchers and to increase their participation in the Action activities. The focus of this Training School was to explore the principles underlying target identification, biochemical and cell-based assay development, small molecule screening and in vitro ADME-Tox profiling as part of lead optimization to endow compounds with multi-targeting activity.
Workshop
 CA15135 multi-targeting Biophysical Training School
Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Germany
2019/01/16 - 2019/01/17 The 2019 NanoGateway Winter School is an initiative to bring together students, researchers and companies from Spain and Portugal working closely in the topic “Nanotechnology for therapy and diagnostics”, a new wave of technologies that will redefine, reshape and eventually transform how we see and how we use medical technologies, therapy and diagnostic methods.
Workshop
 2019 NanoGateway Winter School
International Iberian Nanotechnology Laboratory, Portugal
2018/07/12 - 2018/07/14 The Paul Ehrlich MedChem Euro-PhD Network was established in November 2009 in Palermo, Italy as a collaboration among several European universities with the aim of fostering the education and research training of post-graduate students in Medicinal Chemistry towards PhD Degree.
Conference
 VIII Meeting of the Paul Ehrlich Euro-PhD Network
Universidade do Porto Departamento de Química e Bioquímica, Portugal