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Sónia Celeiro completed her MSc degree in Health Sciences in 2018 (School of Medicine/ University of Minho) and have a BSc degree in Biology-Geology (School of Sciences/ University of Minho) completed in 2016. Currently is doing his PhD in Health Sciences in ICVS/School of Medicine (University of Minho, Braga, Portugal) and Hospital Bambino Gesu - Department of Haemato-Oncology, Cell and Gene Therapy (Rome, Italy). Published 3 articles in journals. Has 1 section(s) of books. Participated in 21 event(s). Participated as Research Fellow in 2 project(s) and as a master's student in 2 work(s) integrated in the major project: "Deciphering the tumorigenic role of the tumour suppressor gene SPINT2 in solid tumours". Has received 2 awards and/or honors. In 2019, was awarded by Liga Portuguesa Contra o Cancro through the Portugal national contest: "Bolsa da Liga Portuguesa Contra o Cancro/ Fundação PT (2018)" with the scientific project: "Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma". In the Ciência Vitae curriculum the most frequent terms in the context of scientific and technological output are: Cancer; Oncobiology; Cell biology; Melanoma; Cervical cancer; Gliomas; Leukemia; Signaling pathways; Targeted therapies; Biomarker; Tumor suppressor gene; Genetic and epigenetics; Methylation; SPINT2; Tumor microenviornment; Immune system; Cancer Metabolism; Cancer pH dynamics; Regulated cell death; Invasion; 3D cell culture; Propolis; . Experience in different techniques as qRT-PCR, phospho-arrays; western-blot, immunohistochemistry, functional assays in 2D and 3D culture models (wound-healing, migration, invasion, cell viability, tumor spheroid growth, metabolism assay (glucose consumption and extracellular lactate)), Chick Chorioallantoic Membrane (CAM) assay and animal experimentation (FELASA C).
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Identification

Personal identification

Full name
Sónia Pires Celeiro

Citation names

  • Sónia Pires Celeiro

Author identifiers

Ciência ID
391C-3373-6D5A
ORCID iD
0000-0002-3211-6492

Email addresses

  • soniaceleiro@med.uminho.pt (Professional)
  • id9536@alunos.uminho.pt (Professional)
  • sonia.celeiro94@gmail.com (Personal)

Telephones

Telephone
  • 253604837 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS) Universidade do Minho Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

  • www.linkedin.com/in/sónia-celeiro-a3bab3196 (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2021/01/01 - 2024
Ongoing
 Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2016/09 - 2018/10
Concluded
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"“Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma”" (THESIS/DISSERTATION)
 17
2017/03 - 2017/03
Concluded
 Cell Functional and Phenotypical Analysis (Curso de mestrado (conclusão do curso de especialização))
Universidade do Minho Escola de Medicina, Portugal
 16
2017/02 - 2017/03
Concluded
 Laboratory Rotation (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/01 - 2017/02
Concluded
 Laboratory Animals Sciences - Category C program according to FELASA recommendations. (Curso de mestrado (conclusão do curso de especialização))
Universidade do Minho Escola de Medicina, Portugal
 16
2016/12 - 2017
Concluded
 Laboratory Rotation (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/09 - 2016/07
Concluded
 Bachelor in Biology-Geology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
 15
2014/10 - 2014/10
Concluded
 Course of Basic Life Support (BLS) (Outros)
European Resuscitation Council, Belgium
Affiliation

Science

Category
Host institution 		Employer
2020/02/01 - 2020/12/31 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01 - 2019/12 Researcher (Research) Liga Portuguesa Contra o Cancro, Portugal
Universidade do Minho Escola de Medicina, Portugal
2016/10 - 2019/01 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Medicina, Portugal
Projects

Grant

Designation Funders
2020/02/01 - 2020/12 Study of the anticancer effect of 3-Bromopyruvate (3-BrPa) in animal model systems of leukemia
UMINHO/BI/81/2020
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 NEWGLAB PHARMA
Ongoing
2019/01/01 - 2019/12/31 Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma
Bolsa LPCC/Fundação PT 2018
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Liga Portuguesa Contra o Cancro
Ongoing

Other

Designation Funders
2021 - Current Assessing the Antitumoral Activity of Portuguese Propolis Fractions in Melanoma
N/A
Researcher
Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Escola de Medicina, Portugal
Ongoing
2020 - Current Study of the anticancer effect of 3-Bromopyruvate (3-BrPa) in animal model systems of leukemia
N/A
Researcher
NEWGLAB PHARMA
2016 - Current Deciphering the tumorigenic role of the tumour suppressor gene SPINT2 in solid tumours
N/A
Researcher
2017 - 2018 Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma - Master's student
N/A
Other
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
2016/10 - 2016/12 Clinical relevance of tumour suppressor gene SPINT2 in Cervical Cancer - Laboratory rotation (Master degree)
N/A
Other
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Sónia Pires-Celeiro; Fátima Baltazar; Marta Viana-Pereira. "3D culture systems as models for solid tumors and cancer metabolism". In Biomaterials for 3D Tumor Modeling, edited by Kundu, Subhas; Reis, Rui L.. London, United Kingdom: Elsevier, 2020.
    Published
Conference abstract
  1. Nshizirungu, J.; Van Cutsem, E.; Bennis, S.; Mellouki, I.; Sekal, M.; Benajah, D.; Lahmidani, N.; et al. "P-195 Gastric adenocarcinoma classification: Association with clinicopathological features and overall survival in Moroccan patients". 2021.
    Published • 10.1016/j.annonc.2021.05.250
  2. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract PN9: Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in melanoma". Paper presented in ICVS Open Day 2019, Braga, 2019.
    Accepted
  3. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract P15: SPINT2 as a therapeutic biomarker in Melanoma". Paper presented in ISCaM 2019, Braga, 2019.
    Accepted
  4. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract PN10: Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in melanoma". Paper presented in ICVS Open Day 2018, Braga, 2018.
    Accepted
  5. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract 43: Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Paper presented in 25th Porto Cancer Meeting, Braga, 2018.
    Accepted
Conference poster
  1. Rafaela Dias Oliveira; Sónia Pires-Celeiro; Baltazar, Fátima; Almeida-Aguiar, Cristina. "Assessing the Antitumoral Activity of Portuguese Propolis Fractions in Melanoma". Paper presented in CUTANEOUS MELANOMA: FROM WHERE TO WHERE?, 2021.
  2. Sónia Pires-Celeiro; Baltazar, Fátima; Reis, Rui Manuel; Viana-Pereira, Marta. "SPINT2: a potential biomarker for melanoma patients". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  3. Sónia Pires-Celeiro; Fátima Balazar; Reis, Rui Manuel; Marta Viana-Pereira. "SPINT2 downregulation in Melanoma influences EMT". Paper presented in EACR 2021 Virtual Congress, 2021.
  4. Joana Pereira-Vieira; Sónia Pires-Celeiro; Fátima Baltazar. "Targeting glycolytic metabolism as a therapeutic strategy for Acute Myeloid Leukemia". Paper presented in EACR 2021 Virtual Congress, 2021.
  5. Sónia Pires-Celeiro; Marta Viana-Pereira. "SPINT2 role and therapeutic influence in Melanoma". Paper presented in Cancer Biology: From Basic to Translational Research, 2020.
  6. Joana Pereira-Vieira; Sónia Pires-Celeiro; Fátima Baltazar. "3-bromopyruvate boosts the effect of chemotherapy in acute myeloid leukaemia by reducing cell antioxidant defence". Paper presented in Cancer Biology: From Basic to Translational Research, 2020.
  7. Sónia Pires-Celeiro. "SPINT2 as a therapeutic biomarker in Melanoma". Paper presented in ISCam 2019, 2019.
  8. Sónia Pires-Celeiro. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Paper presented in ICVS Open Day 2019, 2019.
  9. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Paper presented in 25th Porto Cancer Meeting, 2018, 2018.
  10. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Paper presented in ICVS Open Day 2018, 2018.
Journal article
  1. Ana Rita Caetano; Oliveira, Rafaela; Sónia Pires Celeiro; Ana Sofia Freitas; Susana M. Cardoso; M. Sameiro T. Gonçalves; Maria de Fátima Monginho Baltazar; Almeida-Aguiar, Cristina. "Phenolic Compounds Contribution to Portuguese Propolis Anti-melanoma Activity". Molecules (2023): https://www.mdpi.com/1420-3049/28/7/3107.
    Published • 10.3390/molecules28073107
  2. Oliveira, Rafaela Dias; Sónia Pires Celeiro; Barbosa-Matos, Catarina; Freitas, Ana Sofia; Cardoso, Susana M.; Viana-Pereira, Marta; Almeida-Aguiar, Cristina; Baltazar, Fátima. Corresponding author: Baltazar, Fátima. "Portuguese Propolis Antitumoral Activity in Melanoma Involves ROS Production and Induction of Apoptosis". Molecules 27 11 (2022): 3533. http://dx.doi.org/10.3390/molecules27113533.
    10.3390/molecules27113533
  3. Nshizirungu, Jean Paul; Bennis, Sanae; Mellouki, Ihsane; Sekal, Mohammed; Benajah, Dafr-Allah; Lahmidani, Nada; El Bouhaddouti, Hicham; et al. "Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients". Disease Markers 2021 (2021): 1-12. http://dx.doi.org/10.1155/2021/9980410.
    Published • 10.1155/2021/9980410
  4. Nshizirungu, Jean Paul; Bennis, Sanae; Mellouki, Ihsane; Benajah, Dafr-Allah; Lahmidani, Nada; El Bouhaddoutti, Hicham; Ibn Majdoub, Karim; et al. "Microsatellite Instability Analysis in Gastric Carcinomas of Moroccan Patients". Genetic Testing and Molecular Biomarkers 25 2 (2021): 116-123. http://dx.doi.org/10.1089/gtmb.2020.0146.
    10.1089/gtmb.2020.0146
  5. Pereira, Márcia Santos; Celeiro, Sónia Pires; Costa, Ângela Margarida; Pinto, Filipe; Popov, Sergey; de Almeida, Gisele Caravina; Amorim, Júlia; et al. "Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2". Cellular Oncology 43 1 (2019): 107-121. http://dx.doi.org/10.1007/s13402-019-00475-7.
    Published • 10.1007/s13402-019-00475-7
Thesis / Dissertation
  1. Celeiro, Sónia. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma (18/20)". Master, Universidade do Minho Escola de Medicina, 2018.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/11 - 2020/12 "Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma" Supervisor of Beatriz Peixoto (Laboratory Rotation-Master student) Beatriz Peixoto laboratory rotation was supervised by me and Dr. Marta Viana-Pereira. Genetically modulated melanoma cell lines (SPINT2 overexpression) were used to evaluate SPINT2 therapeutic influence. 2D and 3D cell culture models and specific functional studies with these models were taught to the student (wound-healing assay, tumor spheroid-based migration assay on matrix protein and tumor spheroid growt
Co-supervisor
 Ciências da Saúde (Master)
Universidade do Minho Escola de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/04 - 2021/04 III Jornadas da Ciência - Development of 3D culture systems for in vitro study of tumour pathophysiology (2021/04/08 - 2021/04/10)
Workshop (Other)
 Universidade do Minho Escola de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/01/17 - Current Learn about the fundamental differences between conventional 2D and 3D cell culture approaches and the pros and cons of using them for drug development. Learn how tumor microenvironment affects tissue organization and response to treatment and why it is crucial to incorporate it into pre-clinical models.
Other
 Multimodal Analysis of Anticancer Drug Testing In Tumor-Specific 3D Cell Culture Models - Webinar
Tecan Group Ltd, Switzerland
2022/12/12 - Current Explore the use of hPSC-derived models to study human health, development, and disease Understand the differentiation and characterization of hPSC-derived choroid plexus organoids Discover a protocol that helps to get to the desired clone quickly, with demonstrated savings of valuable reagents, media, and plastic
Other
 Novel methods for the development of stem cell-derived 2D and 3D models - Webinar
SelectScience, United Kingdom

STEMCELL Technologies Inc, Canada
2021/10/14 - 2021/10/15 Disseminate and promote the work developed in the Portugal and Spanish countries to create communication channels and collaboration opportunities among cancer researchers. In addition, emphasis on fostering essential connections among basic, clinical and translational cancer researchers.
Meeting
 II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
Associação Portuguesa de Investigação em Cancro, Portugal
2021/07/14 - 2021/07/14 Business projects that resulted from the science-based ideas supported by HiTech were presented.
Other
 HiTech 2021 - Innovation from Science
HiSeedTech, Portugal
2021/06/09 - 2021/06/12 A virtual congress dedicated to basic, preclinical and translational cancer research across a wide breadth of topics.
Congress
 EACR 2021 Virtual Congress
European Association For Cancer Research, United Kingdom
2021/05/15 - 2021/05/15 Medical meeting about the innovative medicines and appropriate therapeutic strategies in Melanoma
Conference
 II Encontro de Melanoma e Tumores Cutâneos Não Melanoma do Alentejo
2021/04/26 - 2021/04/26 The Congress focused on the latest developments and findings in immuno-oncology therapy as well as targeted therapy.
Conference
 The Virtual congress on Modern Oncology
VIM2021, Israel
2021/04/13 - 2021/04/13 Structuring and problem solving - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal
Workshop
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2021/04/09 - 2021/04/09 Webinar about various projects manly focused on genetic, epigenetic and epidemiological aspects of tumor models to contribute for a better understanding of cancer and the way to fight it.
Other
 VI Jornadas de Investigação em Oncologia em Portugal
Liga Portuguesa Contra o Cancro, Portugal
2021/03/19 - 2021/03/19 Time management - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal.
Workshop
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2021/03/13 - 2021/03/13 I Jornadas de Imunoterapia do Alentejo e Algarve
Other
 I Jornadas de Imunoterapia do Alentejo e Algarve
2021/01/21 - 2021/01/21 Preparation for selection interviews - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal.
Workshop
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2020/09/25 - 2020/09/25 Different thematics of tumor complexity (genetics, biomarkers, tumor microenvironment, tumor metabolism, and new potential therapeutic targets) was addressed, as well as the application of knowledge to improve the diagnosis or treatments of cancer patients.
Other
 WEBINAR: Cancer Biology: From Basic To Translational Research
Liga Portuguesa Contra o Cancro, Portugal
2020/07/14 - 2020/07/14 Drug attrition rates from high throughput screening 2D models have instigated the need for more relevant and clinically predictive models. Researchers have been using a variety of 3D techniques/ models and explore the impact on their research. The real question is can these assays bridge the gap between the convenience of conventional 2D models and the biological relevance of animal models and produce assays that are truly fit for purpose?
Other
 ELRIG webinar: 3D Models – An Alternative to or in combination with traditional 2D Assays for Drug Discovery
ELRIG, United Kingdom

Nexcelom Bioscience, United States
2020/06/23 - 2020/06/23 Unlocking the complexities of drug discovery is an ongoing challenge. In this context, in vitro disease models have provided important tools for the development of new drugs, serving as low-cost screening platforms for drug therapies.
Other
 3D Cell Culture Models: Challenges and Optimized Assays (Webinar)
Corning Inc, United States

Promega Biotech Ibérica, Spain
2019/10/17 - 2019/10/19 ISCaM 2019 6th Annual meeting CANCER METABOLIC REWIRING: MAPPING THE ROAD TO CLINICAL TRANSLATION
Conference
 ISCaM 2019 6th Annual meeting CANCER METABOLIC REWIRING: MAPPING THE ROAD TO CLINICAL TRANSLATION
Universidade do Minho, Portugal

Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/10/03 - 2019/10/03 How to write great papers and get published. Understanding and benefiting from the publishing process. By Elsevier Researcher Academy.
Workshop
 How to Write a Great Research Paper, and Get it Accepted by a Good Journal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/04 - 2019/04 ICVS Open Day 2019
Meeting
 ICVS Open Day
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01 - 2019/01 Nanotechnology for Therapy and Diagnostics, nanoGateway Winter School 2019
Conference
 Nanotechnology for Therapy and Diagnostics
International Iberian Nanotechnology Laboratory, Portugal
2018/04/06 - 2018/04/06 ICVS Open Day 2018
Meeting
 ICVS Open Day
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/04 - 2018/04 25th Porto Cancer meeting 2018 - Cancer Wars: The Immune Force Awakens
Conference
 25th Porto Cancer Meeting 25th Porto Cancer meeting - Cancer Wars: The Immune Force Awakens
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2016 3ª Jornada da Oferta Pós-graduada da ECUM "UM Futuro com Ciência"
Conference
 3ª Jornada da Oferta Pós-graduada da ECUM "UM Futuro com Ciência"
Universidade do Minho Escola de Ciências, Portugal
2014 - 2014 Seminar given by aerospace engineer Bobak Ferdowsi about the "Curiosity" spacecraft that was launched on Mars. It is a robotic vehicle which is collecting photographs and samples for analysis, with the main purpose of identifying life forms.
Seminar
 Palestra de Bobak Ferdowsi (NASA)
Universidade do Minho Escola de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017/10/26 - 2017/10/26 Experimental Approaches in Oncobiology: Lab II Immunohistochemistry method Fundamentals in Genetics, Development and Neoplasia (Curso de mestrado (conclusão do curso de especialização)) Universidade do Minho Escola de Medicina, Portugal

Mentoring / Tutoring

Topic Student name
2021 - Current Assessing the in vitro antimicrobial and antitumor activity of Portuguese propolis - Rafaela Oliveira (Master's student) Rafaela Oliveira
2019/11 - 2019/11 SPINT2 influence in melanoma metabolism - Laboratory Rotation - Master's student Adriana Faria
2018/12 - 2019 Microsatellite instability in gastric cancer - PhD student Jean Paul
2018/05 - 2018/05 Laboratory Rotation - PhD student Matilde Neto
2017/11 - 2018/01 Laboratory Rotation-Master's student Inês Fernandes Lages
2017/07 - 2017/09 Master thesis - Medical student Bruno Peixoto
2017/07/01 - 2017/07/31 Laboratory Rotation-Erasmus/Medical student Bertha Elena Arangure
Distinctions

Award

2020 Best poster in Cancer Biology: From Basic To Translational Research 2020 (Webinar)
Liga Portuguesa Contra o Cancro, Portugal
2019 Project winner of the national contest: "Bolsa da Liga Portuguesa Contra o Cancro/ Fundação PT (2018)"
Liga Portuguesa Contra o Cancro, Portugal