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I am a Research Assistant in the Translational and Chemical, at Instituto de Medicina Molecular (IMM), in Lisbon. I hold an MSc degree in Biological Engineering from Instituto Superior Técnico and a PhD degree with distinction in Biochemistry from the Universidade NOVA de Lisboa. Before starting my PhD studies, I worked for 3 years as a research fellow and, in 2010 I was awarded a FCT PhD Fellowship (Portugal), to perform my studies under the joint supervision of Prof Inês Pereira and Prof Pedro Matias. During my PhD, I learned how to work efficiently and independently and acquired multidisciplinary training in biochemistry, molecular biology, and structural biology. I was responsible for protein purification, biochemical characterization, and crystallization. Throughout my PhD studies, I have conducted extensive studies to be able to determine the structural determinants of oxygen tolerance in a NiFeSe hydrogenase. Moreover, during this period I had also the opportunity to visit groups that allowed me to expand my scientific background to other scientific areas like IR spectroscopy (Dr De Lacey, CSIC, Madrid) and electrochemistry (Dr Christophe Léger, CNRS, Marseille). In 2012, I interrupted my fellowship for 5 months for maternity leave purposes and, at the end of 2014 graduated in Structural Biochemistry. After this, I stayed for a brief period in the Macromolecular Crystallography Unit, at ITQB NOVA, to finish some structural studies. Later in 2015, I moved to Instituto de Medicina Molecular João Lobo Antunes (IMM), to start my postdoctoral studies with Prof Nuno Santos. Here, I worked on a short-term fellowship funded by an NIH Grant (USA) to engineer potent membrane-targeted peptide fusion inhibitors, for antiviral therapy. I was able to quickly adapt and acquire new concepts about basic Virology and gained critical theoretical and practical knowledge in different biophysical techniques. At the end of 2016, I joined the Chemical Biology & Pharmaceutical Biotechnology Unit at IMM. I brought my growing skills in big-picture thinking, molecular biology, and structural biology to bear on some of the large-scale projects being performed in the Unit. Among others, I was responsible for combining efforts with other collaborators to accomplish several project’ tasks, with the goals of investigating the role of biologically relevant proteins in cancer and inflammation and structurally characterizing the binding mode of several inhibitors. I have also sought to identify new target proteins that we could potently and selectively modulate function with new molecules. I was awarded a Postdoctoral FCT Grant in Medical Engineering in 2017, under Prof Bernardes and Prof Santos joint-supervision. At the end of 2019, I interrupted my fellowship for 5 months, for my second maternity leave, and when I was planning to return to the lab in March, the pandemic crisis started. Also in 2019, I started as an Invited Professor in ESTeSL, IPL, where I teach Biochemistry. Currently, I am an Assistant Researcher at iMM (3rd Edition of the Scientific Employment Stimulus) and PI of an Exploratory FCT project. Since 2008 my research has resulted in 30 publications in international, high-impact journals, which have been cited >900 times, with an h-index of 17 (Scopus). Also, I have 2 book chapters and 2 publications in national peer-reviewed journals and >20 abstracts in conferences and was also selected for several oral communications (8), received 2 international poster prizes, and was awarded the Portuguese Young Biophysicist Prize in 2018. I aspire to not only make a great impact on my Institute but on the entire field of targeted therapy, especially for cancer treatment.
Identification

Personal identification

Full name
Marta Franco Coimbra Marques

Citation names

  • Marques, Marta C

Author identifiers

Ciência ID
3A1D-10AB-43BC
ORCID iD
0000-0002-5093-5918
Researcher Id
A-5725-2019
Scopus Author Id
35085375600

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Exact Sciences - Chemical Sciences - Physical Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2010/09/01 - 2014/12/17
Concluded
Bioquímica Estrutural (Doutoramento)
Major in Bioquímica e Biologia Estrutural
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Structural and functional studies of a high activity NiFeSe hydrogenase" (THESIS/DISSERTATION)
Aprovada
2007/05/17
Concluded
Mestrado Integrado em Engenharia Biológica (Mestrado)
Universidade de Lisboa, Portugal
"Validação interna dos métodos de determinação de deoxinivalenol e zearalenona por HPLC com purificação por colunas de imunoafinidade" (THESIS/DISSERTATION)
15
Affiliation

Science

Category
Host institution
Employer
2021/05/01 - Current Auxiliary Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Instituto de Medicina Molecular, Portugal
2017/05/01 - Current Postdoc (Research) Instituto de Medicina Molecular, Portugal
2017/05/01 - Current Visiting Researcher (Research) University of Cambridge Department of Chemistry, United Kingdom
2016/11/01 - 2017/04/30 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2015/09/01 - 2016/10/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2015/05/01 - 2015/08/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/09/01 - 2014/12/17 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011/09/01 - 2011/10/01 Visiting Researcher (Research) Instituto de Catálisis y Petroleoquímicaes, Spain
2010/10/01 - 2010/11/01 Visiting Researcher (Research) Instituto de Catálisis y Petroleoquímicaes, Spain
2008/05/01 - 2010/08/31 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/09/01 - 2009/10/01 Visiting Researcher (Research) Instituto de Catálisis y Petroleoquímicaes, Spain
2007/06/01 - 2008/04/30 Researcher (Research) Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2006/09/01 - 2007/05/31 Research Trainee (Research) Instituto Nacional de Investigação Agrária e Veterinária, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2019/09/01 - 2023/08/31 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
Instituto Politécnico de Lisboa, Portugal

Others

Category
Host institution
Employer
2013/11/01 - 2013/11/30 Investigador visitante Institut de Microbiologie de la Méditerranée, France
2006/03/01 - 2006/07/31 Marketing commercial Verlag Dashofer, Portugal
Projects

Grant

Designation Funders
2017/05/01 - Current Engineering fusion inhibitor peptides against childhood respiratory viruses
SFRH/BPD/118731/2016
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2018/06/01 - Current Stapling strategy of CRM197 to improve stability
H2020 Grant # 653706
Principal investigator
iNEXT: Infrastructure for NMR, EM and X-rays for Translational Research, Netherlands
Ongoing
2021/01/01 - 2025/12/31 Instituto de Medicina Molecular João Lobo Antunes
LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/05/01 - 2023/11/30 A Bispecific antibody to block iron-endocytosis-driven metastasis •
EXPL/MED-QUI/0232/202
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Intracellular Drug Delivery using Small Molecule Drug Conjugates for Prostate Cancer Therapy
PTDC/MED-QUI/28764/2017
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/05/01 - 2021/08/31 ACORN Project-H2020-TWINN-2018 (Spreading Excellence and Widening Participation - Twinning)
Principal investigator
Instituto de Medicina Molecular, Portugal
Conseil de l'Union Europeenne
Ongoing
2018/05/01 - 2021/04/30 Drug delivery of bioactive agents through selective decaging.
PTDC/MED-QUI/28333/2017
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/11/01 - 2017/04/30 Técnicas de Imagem Molecular da Fibrose Hepática (HMSP-ICT/0012/2013)
HMSP-ICT/0012/2013
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia

Harvard University
Ongoing
2015/01/08 - 2016/10/31 Engineering protease-resistant alpha-beta peptides for broad-spectrum antivirals
1R01AI114736-01A1
Post-doc Fellow
National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), EUA
2010/09/01 - 2014/12/17 Structural Determinants of Oxygen Tolerance in a NiFeSe Hydrogenase
PTDC/BBB-BEP/0934/2012
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
2010/09/01 - 2014/12/17 STRUCTURAL AND FUNCTIONAL STUDIES OF A HIGH-ACTIVITY NIFESE HYDROGENASE
SFRH/BD/60879/2009
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/09/30 Study of an ancient mode of energy metabolism: the dissimilatory reduction of sulfite
PTDC/QUI-BIQ/100591/2008
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Metabolic engineering of an anaerobic bacterium for biological hydrogen production
PTDC/BIA-MIC/104030/2008
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 4 - 2011-2012
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/02/28 Quinol oxidation by membrane cytochromes c widely implicated in bacterial respiration - structural studies of the model NrfHA complex
PTDC/BIA-PRO/68486/2006
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/05/01 - 2010/08/31 Towards biohydrogen production – study of a high-activity, oxygen-resistant bacterial hydrogenase
FCT PDCT/BIA-PRO/70429/2006
Research Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Concluded
2008/04 - 2010/08 Towards biohydrogen production – study of a high-activity, oxygen-resistant bacterial hydrogenase
FCT PDCT/BIA-PRO/70429/2006
Fundação para a Ciência e a Tecnologia
2008/06/01 - 2009/04/30 MYCONET- Assessment of information for the identification of emerging risks
Research Fellow
Concluded
2007 - 2007/01/01 Joint-action PT and Spanish from Ministerio de Ciencia e Innovación (Spain)
CTQ2006-12097
PhD Student Fellow
Gobierno de España Ministerio de Economía y Empresa, Spain
Outputs

Publications

Book chapter
  1. Marques, Marta C. "Occurrence of mycobiota in swine feed". In Current Research Topics in Applied Microbiology and Microbial Biotechnology, 407-711. New Jersey, United States: World Scientific Publishing Co, 2008.
    Published
Conference paper
  1. Almeida, Ines Martins; Marques, Marta Franco; Torrado, Ema; Martins, H. Marina. "Occurrence of mycobiota in swine feed". 2009.
    10.1142/9789812837554_0085
Conference poster
  1. Marques, Marta C. "Towards understanding the complexity of molecular interactions: a structure-based approach to develop high affinity leads". Paper presented in Chemical Biology 2018, 2018.
  2. Marques, Marta C. "Towards an engineered O2-tolerant-like proximal FeS cluster in a [NiFeSe] hydrogenases". Paper presented in DGK-AK1-Workshop: Diffraction Data Collection Using Synchrotron Radiation, 2018.
  3. Silva, Patrícia; Augusto, Marcelo T.; Marques, Marta C; Porotto, Matteo; Moscona, Anne; Nuno C. Santos. "Biophysical characterization of lipid-tagged peptides as fusion inhibitors for respiratory viruses". Paper presented in XII PhD Student Meeting, 2018.
  4. Marques, Marta C. "Towards understanding the complexity of molecular interactions: a structure-based approach to develop high affinity leads". Paper presented in Translating Structural Biology into Biomedical Applications, 2018.
  5. Silva, Patrícia; Augusto, Marcelo T.; Marques, Marta C; Porotto, Matteo; Moscona, Anne; Correia dos Santos, Nuno. "Cholesterol-conjugated peptide inhibitors of influenza A virus: biophysical characterization". Paper presented in School of Advanced Science on Biophysical Methods to Study Biomolecular Interactions, 2017.
  6. Marques, Marta C. "Engineering [NiFeSe] hydrogenase variants with an O2-tolerant-like proximal FeS cluster.". Paper presented in 11th International Hydrogenase Conference, 2016.
  7. Marques, Marta C. "Towards an engineered O2-tolerant-like proximal FeS cluster in a [NiFeSe] hydrogenases". Paper presented in 5th ENURS: Meeting of Portuguese Synchrotron Radiation Users, 2016.
  8. Marques, Marta C. "Biophysical analysis of lipid conjugated-peptide fusion inhibitors that target paramyxoviruses". Paper presented in 5th International Iberian Biophysics Congress, 2016.
  9. Marques, Marta C. "Biophysical analysis of lipid conjugated-peptide fusion inhibitors that target influenza virus". Paper presented in 5th International Iberian Biophysics Congress, 2016.
  10. Marques, Marta C. "Structural and functional studies of a high activity NiFeSe hydrogenase". Paper presented in FEBS EMBO Conference Paris, 2014.
  11. Marques, Marta C. "Insights to O2 inactivation in the [NiFeSe] Hydrogenase from Desulfovibrio vulgaris Hildenborough". Paper presented in International Hydrogenase Conference, 2013.
  12. Xiong, Shuangli; Wang, Yingying; Huang, Ni. "The role of selenocysteine in the [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough". Paper presented in Chemistry of Metals in Biological Systems Louvain-La-Neuve, 2011.
    10.1109/icbbe.2011.5780127
  13. Marques, Marta C. "Fusarium spp. occurrence in feeds and cereal grains (Portugal-2007)". Paper presented in BioMicroWorld 2009, 2009.
  14. Marques, Marta C. "Detection of potencially pathogenic yeast on environmental sources in Portugal". Paper presented in BioMicroWorld 2009, 2009.
  15. Marques, Marta C. "The NiFeSe hydrogenase from Desulfovibrio vulgaris Hildenborough shows tolerance to oxygen inactivation". Paper presented in BioMicroWorld 2009, 2009.
  16. Marques, Marta C. "Studies of [NiFeSe] Hydrogenase from Desulfovibrio vulgaris Hildenborough". Paper presented in Workshop of Sulfur Metabolism, 2009.
  17. Marques, Marta C. "The QmoABC complex from Desulfovibrio desulfuricans ATCC 27774: studies on a conserved membrane-bound complex of SRB". Paper presented in Workshop of Sulfur Metabolism, 2009.
  18. Marques, Marta C. "Presença de micotoxinas em alimentos compostos para animais na última década em Portugal- uma revisão". Paper presented in 8º Encontro de Química dos Alimentos, 2008.
  19. Marques, Marta C. "Contribution to the fungal characterization of poultry feed". Paper presented in MicroBiotec 07, 2007.
  20. Marques, Marta C. "Validação indirecta do método de determinação de aflatoxina B1 e de deoxinivalenol por HPLC". Paper presented in 8º Encontro de Química dos Alimentos, 2007.
Journal article
  1. Istrate, Alena; Geeson, Michael B.; Navo, Claudio D.; Sousa, Barbara B.; Marques, Marta C.; Taylor, Ross J.; Journeaux, Toby; et al. "Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents". Journal of the American Chemical Society 144 23 (2022): 10396-10406. http://dx.doi.org/10.1021/jacs.2c02185.
    Published • 10.1021/jacs.2c02185
  2. Marta C. Marques; Diana Lousa; Patrícia M. Silva; André F. Faustino; Claudio M. Soares; Nuno C. Santos. "The Importance of Lipid Conjugation on Anti-Fusion Peptides against Nipah Virus". Biomedicines (2022): https://www.mdpi.com/2227-9059/10/3/703.
    10.3390/biomedicines10030703
  3. Carboni, Filippo; Kitowski, Annabel; Sorieul, Charlotte; Veggi, Daniele; Marques, Marta C.; Oldrini, Davide; Balducci, Evita; et al. "Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates". Chemical Science (2022): http://dx.doi.org/10.1039/d1sc01928g.
    10.1039/d1sc01928g
  4. Afonso, Claudia F.; Marques, Marta C.; Antonio, Joao P. M.; Cordeiro, Carlos; Gois, Pedro M. P.; Cal, Pedro M. S. D.; Bernardes, Goncalo J. L.. "Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones". Angewandte Chemie International Edition (2022): https://publons.com/wos-op/publon/57114037/.
    10.1002/ANIE.202208543
  5. Marques, Marta C; Conde, Joao; Pumroy, Ruth A.; Baker, Charlotte; Rodrigues, Tiago; Guerreiro, Ana; Sousa, Barbara B.; et al. "Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression". ACS Central Science (2021): https://publons.com/wos-op/publon/45783361/.
    In press • 10.1021/ACSCENTSCI.1C00070
  6. Neukirch, Konstantin; Alsabil, Khaled; Dinh, Chau-Phi; Bilancia, Rossella; Raasch, Martin; Ville, Alexia; Cerqua, Ida; et al. "Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation". Journal of Medicinal Chemistry (2021): https://publons.com/wos-op/publon/48739624/.
    10.1021/ACS.JMEDCHEM.1C00806
  7. Sousa, Bárbara B.; Sousa, Marcos F. Q.; Marques, Marta C.; Seixas, João D.; Brito, José A.; Matias, Pedro M.; Bernardes, Gonçalo J. L.; Roldão, António. "A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening". Bioprocess and Biosystems Engineering (2020): http://dx.doi.org/10.1007/s00449-020-02421-6.
    In press • 10.1007/s00449-020-02421-6
  8. Marques, Marta C.; Albuquerque, Inês S.; Vaz, Sandra H.; Bernardes, Gonçalo J. L.. "Overexpression of Osmosensitive Ca2+-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells". Biochemistry 58 26 (2019): 2861-2866. http://dx.doi.org/10.1021/acs.biochem.9b00224.
    10.1021/acs.biochem.9b00224
  9. Sun, S.; Akkapeddi, P.; Marques, M.C.; Martínez-Sáez, N.; Torres, V.M.; Cordeiro, C.; Boutureira, O.; et al. "One-pot stapling of interchain disulfides of antibodies using an isobutylene motif". Organic and Biomolecular Chemistry 17 7 (2019): 2005-2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061490867&partnerID=MN8TOARS.
    10.1039/c8ob02877j
  10. Rodrigues, T.; Werner, M.; Roth, J.; Da Cruz, E.H.G.; Marques, M.C.; Akkapeddi, P.; Lobo, S.A.; et al. "Machine intelligence decrypts ?-lapachone as an allosteric 5-lipoxygenase inhibitor". Chemical Science 9 34 (2018): 6899-6903. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000444554100002&KeyUID=WOS:000444554100002.
    10.1039/c8sc02634c
  11. Bertoldo, J.B.; Rodrigues, T.; Dunsmore, L.; Aprile, F.A.; Marques, M.C.; Rosado, L.A.; Boutureira, O.; et al. "A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases". Chem 3 4 (2017): 665-677. http://www.scopus.com/inward/record.url?eid=2-s2.0-85036511718&partnerID=MN8TOARS.
    10.1016/j.chempr.2017.07.009
  12. Marta C Marques; Cristina Tapia; Oscar Gutiérrez-Sanz; Ana Raquel Ramos; Kimberly L Keller; Judy D Wall; Antonio L De Lacey; et al. "The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis". Nature Chemical Biology (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000399004000016&KeyUID=WOS:000399004000016.
    10.1038/NCHEMBIO.2335
  13. Marques, Marta C. "H2 fueled ATP synthesis: mimicking an electrode-assisted cellular respiration". Angewandte Chemie Int Ed (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000377918400013&KeyUID=WOS:000377918400013.
    10.1002/anie.201600752
  14. Ceccaldi, P.; Marques, M.C.; Fourmond, V.; Pereira, I.C.; Léger, C.. "Oxidative inactivation of NiFeSe hydrogenase". Chemical Communications 51 75 (2015): 14223-14226. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360792800018&KeyUID=WOS:000360792800018.
    10.1039/c5cc05930e
  15. Gutiérrez-Sanz, Ó.; Tapia, C.; Marques, M.C.; Zacarias, S.; Vélez, M.; Pereira, I.A.C.; Delacey, A.L.. "Corrigendum: Induction of a Proton Gradient across a Gold-Supported Biomimetic Membrane by Electroenzymatic H<inf>2</inf> Oxidation". Angewandte Chemie - International Edition 54 33 (2015): 9439-9439. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938359510&partnerID=MN8TOARS.
    10.1002/anie.201505889
  16. Gutiérrez-Sanz, Ó.; Tapia, C.; Marques, M.C.; Zacarias, S.; Vélez, M.; Pereira, I.A.C.; De Lacey, A.L.; Marques, Marta C. "Induction of a proton gradient across a gold-supported biomimetic membrane by electroenzymatic H2 oxidation". Angewandte Chemie - International Edition 54 9 (2015): 2684-2687. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923116851&partnerID=MN8TOARS.
    10.1002/anie.201411182
  17. Marques, M. C.; Gutierrez-Sanz, O.; De Lacey, A.; Matias, P.; Pereira, I.. "Structural and functional studies of a high-activity [NiFeSe] hydrogenase". The FEBS Journal (2014): https://publons.com/wos-op/publon/28024949/.
  18. Gutiérrez-Sanz, O.; Marques, M.C.; Baltazar, C.S.A.; Fernández, V.M.; Soares, C.M.; Pereira, I.A.C.; De Lacey, A.L.. "Influence of the protein structure surrounding the active site on the catalytic activity of [NiFeSe] hydrogenases". Journal of Biological Inorganic Chemistry 18 4 (2013): 419-427. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000316819300002&KeyUID=WOS:000316819300002.
    10.1007/s00775-013-0986-4
  19. Gutiérrez-Sanz, O.; Marques, M.; Pereira, I.A.C.; De Lacey, A.L.; Lubitz, W.; Rüdiger, O.. "Orientation and function of a membrane-bound enzyme monitored by electrochemical surface-enhanced infrared absorption spectroscopy". Journal of Physical Chemistry Letters 4 17 (2013): 2794-2798. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883768526&partnerID=MN8TOARS.
    10.1021/jz4013678
  20. Marques, M.C.; Coelho, R.; Pereira, I.A.C.; Matias, P.M.. "Redox state-dependent changes in the crystal structure of [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough". International Journal of Hydrogen Energy 38 21 (2013): 8664-8682. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000322052800008&KeyUID=WOS:000322052800008.
    10.1016/j.ijhydene.2013.04.132
  21. Pereira, I.A.C.; Ramos, A.R.; Grein, F.; Marques, M.C.; da Silva, S.M.; Venceslau, S.S.. "A comparative genomic analysis of energy metabolism in sulfate reducing bacteria and archaea". Frontiers in Microbiology 2 APR (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79960354818&partnerID=MN8TOARS.
    10.3389/fmicb.2011.00069
  22. Baltazar, C.S.A.; Marques, M.C.; Soares, C.M.; DeLacey, A.M.; Pereira, I.A.C.; Matias, P.M.. "Nickel-iron-selenium hydrogenases - An overview". European Journal of Inorganic Chemistry 7 (2011): 948-962. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951883377&partnerID=MN8TOARS.
    10.1002/ejic.201001127
  23. Gutiérrez-Sánchez, C.; Olea, D.; Marques, M.; Fernández, V.M.; Pereira, I.A.C.; Vélez, M.; Lacey, A.L.D.. "Oriented immobilization of a membrane-bound hydrogenase onto an electrode for direct electron transfer". Langmuir 27 10 (2011): 6449-6457. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000290292900087&KeyUID=WOS:000290292900087.
    10.1021/la200141t
  24. Almeida, Ines; Marina Martins, H.; Marques, Marta; Bernardo, F.. "Fusarium spp. occurrence in feeds and cereal grains (Portugal-2007)". Microorganisms in Industry and Environment: from Scientific and Industrial Research to Consumer Products (2011): https://publons.com/wos-op/publon/29040638/.
    10.1142/9789814322119_0084
  25. Almeida, I.; Martins, H.M.; Marques, M.F.; Magalhães, S.; Bernardo, F.. "Mycobiota and Ochratoxin A in laboratory micefeed: Preliminary study". Veterinary Research Communications 34 4 (2010): 381-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955489657&partnerID=MN8TOARS.
    10.1007/s11259-010-9356-7
  26. Gutiérrez-Sánchez, C.; Rüdiger, O.; Fernández, V.M.; De Lacey, A.L.; Marques, M.; Pereira, I.A.C.. "Interaction of the active site of the Ni-Fe-Se hydrogenase from Desulfovibrio vulgaris Hildenborough with carbon monoxide and oxygen inhibitors". Journal of Biological Inorganic Chemistry 15 8 (2010): 1285-1292. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649918291&partnerID=MN8TOARS.
    10.1007/s00775-010-0686-2
  27. Marques, M.C.; Coelho, R.; De Lacey, A.L.; Pereira, I.A.C.; Matias, P.M.. "The three-dimensional structure of [nifese] hydrogenase from desulfovibrio vulgaris hildenborough: A hydrogenase without a bridging ligand in the active site in its oxidised, "as-isolated" state". Journal of Molecular Biology 396 4 (2010): 893-907. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000275385600007&KeyUID=WOS:000275385600007.
    10.1016/j.jmb.2009.12.013
  28. Marques, M.; Coelho, R.; Pereira, I.A.C.; Matias, P.M.. "Purification, crystallization and preliminary crystallographic analysis of the [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65 9 (2009): 920-922. http://www.scopus.com/inward/record.url?eid=2-s2.0-69849083903&partnerID=MN8TOARS.
    10.1107/S1744309109031261
  29. Marques, Marta C. "Comparison of the validation of two analytical methods for fungal toxins according to RELACRE and the European Decision 2002/657/EC". Revista Portuguesa de Ciências Veterinárias 103 565-566 (2008): 83-89. http://www.fmv.ulisboa.pt/spcv/edicao/6_2008/83-89.htm.
    Published
  30. Marques, M.F.; Martins, H.M.; Costa, J.M.; Bernardo, F.. "Co-occurrence of deoxynivalenol and zearalenone in crops marketed in portugal". Food Additives and Contaminants: Part B Surveillance 1 2 (2008): 130-133. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000262818300007&KeyUID=WOS:000262818300007.
    10.1080/02652030802253983
  31. Marina Martins, H.; Almeida, I.; Marques, M.F.; Guerra, M.M.. "Fumonisins and deoxynivalenol in corn-based food products in Portugal". Food and Chemical Toxicology 46 7 (2008): 2585-2587. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000257480200042&KeyUID=WOS:000257480200042.
    10.1016/j.fct.2008.03.030
  32. Martins, H.M.; Almeida, I.; Marques, M.; Bernardo, F.. "Interaction of wild strains of Aspergilla with Aspergillus parasiticus ATCC15517 on aflatoxins production". International Journal of Molecular Sciences 9 3 (2008): 394-400. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000254465000015&KeyUID=WOS:000254465000015.
    10.3390/ijms9030394
  33. Martins, H.M.; Marques, M.; Almeida, I.; Guerra, M.M.; Bernardo, F.. "Mycotoxins in feedstuffs in Portugal: An overview". Mycotoxin Research 24 1 (2008): 19-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-65149106190&partnerID=MN8TOARS.
    10.1007/BF02985266
Thesis / Dissertation
  1. Marques, Marta C. "Structural and functional studies of a high activity NiFeSe Hydrogenase". PhD, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2014. http://hdl.handle.net/10362/14185.
  2. Marques, Marta Franco Coimbra. "Structural and functional studies of a high activity NiFeSe Hydrogenase". PhD, 2014. http://hdl.handle.net/10362/14185.
  3. Marques, Marta C. "Validação Interna dos Métodos de Determinação de Deoxinivalenol e Zearalenona por HPLC com Purificação por Colunas de Imunoafinidade: Pesquisa de deoxinivalenol e zearalenona em milhos e alimentos compostos para animais". Master, Universidade de Lisboa Instituto Superior Técnico, 2007. https://fenix.tecnico.ulisboa.pt/cursos/lebl-pb/dissertacao/2353642080813.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/09/06 Biochemical and Biophysical Characterization of the Human Recombinant BMX with Covalent Inhibitors I NOVA Biophysyca International Conference
"Universidade NOVA de Lisboa (Lisboa, Portugal)
2019/09/06 Overexpression of Osmosensitive Ca2+-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells NOVA Biophysica International Conference
Universidade Nova de Lisboa (Lisboa, Portugal)
2018/10/03 Towards understanding the complexity of molecular interactions: a structure-based approach to develop high affinity leads iMM Postdoc Day 2018
iMM JLA (Lisboa, Portugal)
2018/07/09 The role of selenocysteine in the catalytic properties and maturation of [NiFeSe] hydrogenases, Biophysics Party Biophysics Party
Sociedade Portuguesa de Biofísica (Oeiras, Portugal)
2018/06/17 The role of selenocysteine in the catalytic properties and maturation of [NiFeSe] hydrogenases 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics
Universidade de Castellon (Castellón de La Plana, Spain)
2017/09/27 ATP synthesis and biosensing coupled to the electroenzymatic activity of a hydrogenase on an electrode/biomimetic membrane interface Proceedings 5th International Symposium on Autonomous Decentralized Systems ISADS-01
IEEE (Barcelona, Spain)
2017/06/03 The role of selenocysteine in the catalytic properties and maturation of [NiFeSe] hydrogenases Hydrogenase Conference
CNRS Marseille (Marseille, France)
2017 A water-mediated mechanism of Protein Tyrosine Phosphatase A: how M. tuberculosis copes with oxidative stress MiniSymposium Looking for new ways to fight tuberculosis
Instituto de Tecnologia Química e Biológica (Oeiras, Portugal)
2016/06/04 Biophysical analysis of peptide fusion inhibitors that target paramyxoviruses FEBS-IUBMB Workshop
FEBS IUBMB (Sevilha, Spain)
2016/01/15 Transfer Knowledge session for PhD students Time Management and Leadership Skills Workshop
Instituto de Medicina Molecular (Lisboa, Portugal)
2016/01/14 Structural Biochemistry of proteins: X-Ray Crystallography and Stability Studies Programa de Doutoramento LisbonBiomed
instituto de Medicina Molecular (Lisboa, Portugal)
2013/11/04 Structural and functional studies of a high-activity [NiFeSe] hydrogenase Short talk
Christophe Léger, CNRS (Marselha, France)
2008/05/06 Incidence of Fusarium Toxins in feeds marketed in Portugal 5th Fusarium Toxin Forum
European Commission DG Health and Consumer Protection (Bruxelas, Belgium)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2024/02/01 - 2027/01/31 Development Of Diazocarbonylacrylic Reagents For Late-Stage Fluorination Of Proteins
Co-supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2024/01/01 - 2025/03/31 Structural and functional studies of new therapeutic targets in cancer
Supervisor
Master in Molecular and Cell Biology (Master)
Universidade de Aveiro, Portugal
2018/01/01 - 2019/10/10 X-ray crystal structure of Bone Marrow Tyrosine Kinase in Chromosome X with covalent ligands
Supervisor
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Instituto de Medicina Molecular, Portugal
2015/10/01 - 2016/06/30 Broad-spectrum antiviral peptides against respiratory viruses
Co-supervisor
Bioquímica (Master)
Instituto de Medicina Molecular, Portugal
2013/01/02 - 2013/03/03 Melhorar a tolerância ao O2 numa hidrogenase [NiFeSe] de alta actividade.
Co-supervisor
Bioquímica (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2017/01/15 - 2017/01/16 IMM Post-Doc Day: Gender Balance in Science. Portugal. Função: Organização do programa científico e logística do encontro. (2017/01/15 - 2017/01/16)
Meeting (Member of the Organising Committee)
Instituto de Medicina Molecular, Portugal
2016/10/19 - 2016/10/21 3rd Post-Doc Retreat. Portugal. Função: Organização coordenada entre as associações de Pós-Docs do ITQB, IGC, IMM e Fundação Champalimaud (2016/10/19 - 2016/10/21)
Meeting (Member of the Organising Committee)
Instituto de Medicina Molecular, Portugal

Fundação Champalimaud, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016/06/01 - 2016/06/07 Leaderships and Management Course for Pos-Docs. (2016/06/01 - 2016/06/07)
Seminar (Member of the Organising Committee)
Instituto de Medicina Molecular, Portugal
2009/03/15 - 2009/03/18 EMBO-FEMS Workshop on Microbial Sulfur Metabolism (2009/01/01 - 2009/03/18)
Workshop (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/11/21 SCREENING INNATE IMMUNOTHERAPY STRATEGIES IN ZEBRAFISH XENOGRAFT MODELS
(Thesis) Main arguer
INÊS JESUS OLIVEIRA (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09 X-ray crystal structure of Human Liver GAPDH with a selective inhibitor
Supervisor
Rafaela Martins (Master)
Universidade Nova de Lisboa, Portugal
2018/10/10 X-ray crystal structure of Bone Marrow Tyrosine Kinase in Chromosome X with covalent ligands
Supervisor
BÁRBARA BEATRIZ DA COSTA BOTELHO SOUSA (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Association member

Society Organization name Role
2015/09/01 - Current Membro da Sociedade Portuguesa de Biofísica
2009/01/01 - Current Sociedade Portuguesa de Bioquímica
2016/01/01 - 2017/01/01 IMM Postdoctoral Association Elected member

Committee member

Activity description
Role
Institution / Organization
2016/01/01 - Current Membro do comité de tese - Arguente. Ana Guerreiro. CAML PhD Programme “Glycoconjugate vaccines against Influenza“,
Member
Instituto de Medicina Molecular, Portugal
2016/01/01 - 2018/12/31 Membro do comité de tese - Arguente. Charlotte Baker. CAML PhD Programme. “Role of TRPV channels in glioblastoma"
Member
Instituto de Medicina Molecular, Portugal

Consulting

Activity description Institution / Organization
2023/11/01 - 2025/10/31 Collaboration with the Research Innovation Office on several projects in collaboration with iMM. PHAGECON - Serviços e Consultoria Farmacêutica Ltd, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/10/15 - 2024/08/31 Responsável pelas aulas praticas das disciplinas Bioquímica I e II. Farmácia e Ciencias da Nutrição (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017/03/25 Igualdade de Género na Ciência Diário de Notícias

Mentoring / Tutoring

Topic Student name
2019/01/01 - Current Protein Biochemistry and structural biology Bárbara Sousa
2018/02/01 - Current Site selective modification of Lysines Cláudia Afonso
2017/05/01 - Current Protein Biochemistry Maria Inês Albuquerque
2023/01/12 - 2026/11/30 Development of Direct Photoredox Fluorination of Proteins Malamatenia Papavasileiou
2018/01/01 - 2019/01/31 Biophysical characterisation of monoclonal antibodies Padma Akkapeddi
2013/01/01 - 2014/12/31 Structural determinants of oxygen tolerance in a NiFeSe hydrogenase Sónia Zacarias

Other jury / evaluation

Activity description Institution / Organization
2023/05/19 - Current Arguência na Tese "Applications of Atomic Force Microscopy in Disease, Mestrado Integrado em Medicina Universidade de Lisboa Faculdade de Medicina, Portugal
Distinctions

Award

2018 Jovem Biofísico 2018
Sociedade Portuguesa de Biofísica, Portugal
2015 Best Poster Award
Bioelectrochemical Society, France
2014 Poster of the Day by Embo Reports no FEBS EMBO Paris 2014 Congress
EMBO Press, Germany

Title

2018 Medalha de Mérito Municipal
Câmara Municipal de Tondela, Portugal

Other distinction

2021 CEEC Contract 3rd Edition- Assistant Researcher
Fundação para a Ciência e a Tecnologia, Portugal
2018 Travel Fellowship
Instituto de Medicina Molecular, Portugal
2017 FCT Postdoctoral Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2015 Travel Fellowship
Federation of European Biochemical Societies, United Kingdom
2013 Travel Fellowship
Federation of European Biochemical Societies, United Kingdom
2010 FCT PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2009 Short-term fellowship for research period in Spain
Luso-Spanish Joint Action funded by CRUP, Spain