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Bárbara Isabel Sousa Castanheira received in 2020 a Bachelor degree in Medicinal Chemistry from the Faculty of Sciences and Technology of University of Coimbra and in 2022 a Master degree in Biochemistry from the same institution. Her dissertation, under the supervision of Doctor Ana Cristina Rego, aimed to analyse the influence of the activation of glutamate receptors, namely, Syn and ESyn NMDARs on CREB activation associated with changes in intracellular Ca2+ levels, mitochondrial Ca2+ retention and mitochondrial transmembrane potential, and their correlation with mRNA levels of two CREB-regulated genes, BDNF and GADD45, in AD primary cortical neurons derived from APP/PS1 transgenic mice (producing intracellular Aß) or Wistar rat cortical neurons exposed to Aß1-42 (AßO) oligomers. Furthermore, it aimed to analysed the influence of histone deacetylase inhibitors (HDACis), tacedinaline and sodium butyrate, under these experimental conditions. Since 2022, she has been a research fellow at BioMark research group from the Chemical Engineering Department in University of Coimbra, where she has been doing research under the OligoFIT project, where she pretends to develop a specific and sensitive immunosensor to alpha-synuclein protein.
Identification

Personal identification

Full name
Bárbara Castanheira

Citation names

  • Castanheira, Bárbara

Author identifiers

Ciência ID
3A1F-8632-B9A2
ORCID iD
0000-0002-4510-8598

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Engineering and Technology - Nano-technology - Nano-materials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2024/04/01 - 2024/04/05
Concluded
Principles of Genetic Manipulation in Mice - a practical approach, 1st edition (Pós-Graduação)
Universidade do Porto Faculdade de Medicina, Portugal
17
2023/05 - 2023/07
Concluded
Anti-aging therapy: pharmacological and non-pharmacological approach (Pós-Graduação)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
16
2020/10/16 - 2022/09/30
Concluded
Biochemistry (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - Role of HDAC inhibitor (s)" (THESIS/DISSERTATION)
17
2016/09/12 - 2020/07/30
Concluded
Medicinal Chemistry (Licenciatura)
Universidade de Coimbra Departamento de Química, Portugal
""Therapeutic Potential of NRF2 Modulators in Acute Myeloid Leukemia"" (THESIS/DISSERTATION)
13
Affiliation

Science

Category
Host institution
Employer
2022/11/24 - 2023/11/24 Researcher (Research) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
Projects

Grant

Designation Funders
2022/11/24 - Current Oligomer-Focused Screening and Individualized Therapeutics to target Neurodegenerative Disorders
JPCOFUND2/0001/2019
Research Fellow
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Castanheira, Bárbara. "Development of surface to capture Endotoxins in water". Paper presented in XXV Meeting of the Portuguese Electrochemical Society, 2023.
  2. Castanheira, Bárbara; Marinho, Daniela; Ildete Luísa de Araújo Ferreira; Ana Cristina Carvalho Rego. "Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - Role of HDAC inhibitor(s)". Paper presented in 36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência, 2022.
Thesis / Dissertation
  1. "Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - Role of HDAC inhibitor (s)". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2022. http://hdl.handle.net/10316/104727.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/30 Immunosensor for alpha-synuclein detection in Parkinson’s Disease in real samples XXV Meeting of the Portuguese Electrochemical Society
Portuguese Electrochemical Society (Coimbra, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/02 - 2023/06 Development of surfaces to capture aquatic contaminants: bacterial endotoxins
Co-supervisor
Degree in Biochemical Engineering (Degree)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2020/02/18 - 2020/02/19 The V Encontro Científico organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra has the motto "Chemistry - A Science of Development and Innovation", and I was part of the Organizing Committee. (2020/02/18 - 2020/02/19)
Meeting (Member of the Organising Committee)
Universidade de Coimbra Departamento de Química, Portugal
2019/02/19 - 2019/02/20 The IV Encontro Científico organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra had the motto "Green Chemistry: A Rethinking of Chemistry", and I was part of the Organizing Committee. (2019/02/19 - 2019/02/20)
Meeting (Member of the Organising Committee)
Universidade de Coimbra Departamento de Química, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/02/11 - 2023/02/11 Workshop entitled "Nanoparticle Production and Characterization for Biomedical Applications"
Workshop
Workshop entitled “Nanoparticle Production and Characterization for Biomedical Applications”
Faculdade de Engenharia da Universidade do Porto, Portugal
2023/02/10 - 2023/02/11 Latest advances in research on Alzheimer's disease, namely on the disorders, diagnosis and therapy of this disease.
Symposium
2 nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Faculdade de Engenharia da Universidade do Porto, Portugal
2022/07/01 - 2022/07/02 Participation in the 36th Annual Meeting. Presentation of my work developed in the Master's Thesis, in the form of a Poster "Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - role of HDAC inhibitor(s) ".
Meeting
36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/01/25 - 2022/01/27 Participation in the CIMAGO Webinar with the themes: 1. Precision Medicine and New Technologies in Cancer; 2. Cell Therapy and Cancer; 3. Communication in Science and Health.
Seminar
Webinar Cimago
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia, Portugal
2021/02/28 - 2021/03/30 Participation in a cycle of online sessions "Brain Gain: Discovering Neuroscience", which took place on March 10, 17, 24 and 31, 2021. In this sessions, topics related to neurosciences were addressed, with particular emphasis on the work carried out in Portuguese institutions.
Other
Brain Gain: À Descoberta das Neurociências
Universidade de Coimbra, Portugal
2021/03/25 - 2021/03/27 Presenting the sub-areas of Chemistry, from academia to industry.
Congress
Digital Colloquium of Chemistry Students
Universidade de Coimbra, Portugal
2021/03/18 - 2021/03/19 Participation in the VI Encontro Científico organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, with the motto "Chemistry - A Current and Future Science".
Meeting
VI Encontro Científico do Núcleo de Estudantes de Química
Universidade de Coimbra Departamento de Química, Portugal
2019/11/05 - 2019/11/06 The VII Feira de Emprego e Empreendedorismo organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, featured highly renowned companies and had as its main objective to make known the greatest diversity of what Chemistry does.
Meeting
VII Feira de Emprego e Empreendedorismo
Universidade de Coimbra Departamento de Química, Portugal
2018/02/20 - 2018/02/21 Participation in the III Scientific Meeting organized by the Nucleus of Chemistry Students of the Academic Association of Coimbra, whose motto was "Meet with Chemistry".
Meeting
III Encontro Científico do Núcleo de Estudantes de Química
Universidade de Coimbra Departamento de Química, Portugal
2017/10/24 - 2017/10/25 Participation in the V Feira de Emprego e Empreendedorismo organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, projected renowned companies and had as its main objective "bringing closer and providing interaction between newly graduated students and companies that are recruiting".
Meeting
V Feira de Emprego e Empreendedorismo
Universidade de Coimbra Departamento de Química, Portugal
2017/04/06 - 2017/04/09 Participation in the V National Meeting of Chemistry Students, organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, with the theme "Chemistry: Bringing the Future Closer!" The main objective of this event was to provide information on the business market in Portugal.
Meeting
V National Meeting of Chemistry Students
Universidade de Coimbra Departamento de Química, Portugal

Association member

Society Organization name Role
2023/02/17 - Current Fundação Infantil Ronald McDonald Volunteer
2018/09 - 2020/09 Núcleo de Estudantes de Química da Associação Académica de Coimbra Colaboradora no Pelouro da Pedagogia e Ciência