Bárbara Castanheira (3A1F-8632-B9A2)

Curriculum Vitae

Bárbara Castanheira

Bárbara Isabel Sousa Castanheira received in 2020 a Bachelor degree in Medicinal Chemistry from the Faculty of Sciences and Technology of University of Coimbra and in 2022 a Master degree in Biochemistry from the same institution. Her dissertation, under the supervision of Doctor Ana Cristina Rego, aimed to analyse the influence of the activation of glutamate receptors, namely, Syn and ESyn NMDARs on CREB activation associated with changes in intracellular Ca2+ levels, mitochondrial Ca2+ retention and mitochondrial transmembrane potential, and their correlation with mRNA levels of two CREB-regulated genes, BDNF and GADD45, in AD primary cortical neurons derived from APP/PS1 transgenic mice (producing intracellular Aß) or Wistar rat cortical neurons exposed to Aß1-42 (AßO) oligomers. Furthermore, it aimed to analysed the influence of histone deacetylase inhibitors (HDACis), tacedinaline and sodium butyrate, under these experimental conditions. Since 2022, she has been a research fellow at BioMark research group from the Chemical Engineering Department in University of Coimbra, where she has been doing research under the OligoFIT project, where she pretends to develop a specific and sensitive immunosensor to alpha-synuclein protein.

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Identification

Personal identification

Full name: Bárbara Castanheira

Citation names

Castanheira, Bárbara

Author identifiers

Ciência ID: 3A1F-8632-B9A2
ORCID iD: 0000-0002-4510-8598

Websites

https://www.linkedin.com/in/b%C3%A1rbara-castanheira-8990a71b3 (Social media)

Knowledge fields

Natural sciences - Biological Sciences - Molecular Biology
Engineering and Technology - Nano-technology - Nano-materials

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
English	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Intermediate (B1)

Education

	Degree	Classification
2024/04/01 - 2024/04/05 Concluded	Principles of Genetic Manipulation in Mice - a practical approach, 1st edition (Pós-Graduação) Universidade do Porto Faculdade de Medicina, Portugal	17
2023/05 - 2023/07 Concluded	Anti-aging therapy: pharmacological and non-pharmacological approach (Pós-Graduação) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	16
2020/10/16 - 2022/09/30 Concluded	Biochemistry (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal "Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - Role of HDAC inhibitor (s)" (THESIS/DISSERTATION)	17
2016/09/12 - 2020/07/30 Concluded	Medicinal Chemistry (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal ""Therapeutic Potential of NRF2 Modulators in Acute Myeloid Leukemia"" (THESIS/DISSERTATION)	13

Affiliation

Science

	Category Host institution	Employer
2022/11/24 - 2023/11/24	Researcher (Research)	Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
	Universidade de Coimbra Departamento de Engenharia Quimica, Portugal

Projects

Grant

	Designation	Funders
2022/11/24 - Current	Oligomer-Focused Screening and Individualized Therapeutics to target Neurodegenerative Disorders JPCOFUND2/0001/2019 Research Fellow Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Outputs

Publications

Conference poster

Castanheira, Bárbara. "Development of surface to capture Endotoxins in water". Paper presented in XXV Meeting of the Portuguese Electrochemical Society, 2023.
Castanheira, Bárbara; Marinho, Daniela; Ildete Luísa de Araújo Ferreira; Ana Cristina Carvalho Rego. "Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - Role of HDAC inhibitor(s)". Paper presented in 36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência, 2022.

Thesis / Dissertation

"Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - Role of HDAC inhibitor (s)". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2022. http://hdl.handle.net/10316/104727.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/09/30	Immunosensor for alpha-synuclein detection in Parkinson’s Disease in real samples	XXV Meeting of the Portuguese Electrochemical Society Portuguese Electrochemical Society (Coimbra, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/02 - 2023/06	Development of surfaces to capture aquatic contaminants: bacterial endotoxins Co-supervisor	Degree in Biochemical Engineering (Degree) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2020/02/18 - 2020/02/19	The V Encontro Científico organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra has the motto "Chemistry - A Science of Development and Innovation", and I was part of the Organizing Committee. (2020/02/18 - 2020/02/19) Meeting (Member of the Organising Committee)	Universidade de Coimbra Departamento de Química, Portugal
2019/02/19 - 2019/02/20	The IV Encontro Científico organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra had the motto "Green Chemistry: A Rethinking of Chemistry", and I was part of the Organizing Committee. (2019/02/19 - 2019/02/20) Meeting (Member of the Organising Committee)	Universidade de Coimbra Departamento de Química, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2023/02/11 - 2023/02/11	Workshop entitled "Nanoparticle Production and Characterization for Biomedical Applications" Workshop	Workshop entitled “Nanoparticle Production and Characterization for Biomedical Applications” Faculdade de Engenharia da Universidade do Porto, Portugal
2023/02/10 - 2023/02/11	Latest advances in research on Alzheimer's disease, namely on the disorders, diagnosis and therapy of this disease. Symposium	2 nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics Faculdade de Engenharia da Universidade do Porto, Portugal
2022/07/01 - 2022/07/02	Participation in the 36th Annual Meeting. Presentation of my work developed in the Master's Thesis, in the form of a Poster "Analysis of CREB-regulated genes in cellular models of Alzheimer's Disease - role of HDAC inhibitor(s) ". Meeting	36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência Universidade de Lisboa Faculdade de Medicina, Portugal
2022/01/25 - 2022/01/27	Participation in the CIMAGO Webinar with the themes: 1. Precision Medicine and New Technologies in Cancer; 2. Cell Therapy and Cancer; 3. Communication in Science and Health. Seminar	Webinar Cimago Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia, Portugal
2021/02/28 - 2021/03/30	Participation in a cycle of online sessions "Brain Gain: Discovering Neuroscience", which took place on March 10, 17, 24 and 31, 2021. In this sessions, topics related to neurosciences were addressed, with particular emphasis on the work carried out in Portuguese institutions. Other	Brain Gain: À Descoberta das Neurociências Universidade de Coimbra, Portugal
2021/03/25 - 2021/03/27	Presenting the sub-areas of Chemistry, from academia to industry. Congress	Digital Colloquium of Chemistry Students Universidade de Coimbra, Portugal
2021/03/18 - 2021/03/19	Participation in the VI Encontro Científico organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, with the motto "Chemistry - A Current and Future Science". Meeting	VI Encontro Científico do Núcleo de Estudantes de Química Universidade de Coimbra Departamento de Química, Portugal
2019/11/05 - 2019/11/06	The VII Feira de Emprego e Empreendedorismo organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, featured highly renowned companies and had as its main objective to make known the greatest diversity of what Chemistry does. Meeting	VII Feira de Emprego e Empreendedorismo Universidade de Coimbra Departamento de Química, Portugal
2018/02/20 - 2018/02/21	Participation in the III Scientific Meeting organized by the Nucleus of Chemistry Students of the Academic Association of Coimbra, whose motto was "Meet with Chemistry". Meeting	III Encontro Científico do Núcleo de Estudantes de Química Universidade de Coimbra Departamento de Química, Portugal
2017/10/24 - 2017/10/25	Participation in the V Feira de Emprego e Empreendedorismo organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, projected renowned companies and had as its main objective "bringing closer and providing interaction between newly graduated students and companies that are recruiting". Meeting	V Feira de Emprego e Empreendedorismo Universidade de Coimbra Departamento de Química, Portugal
2017/04/06 - 2017/04/09	Participation in the V National Meeting of Chemistry Students, organized by the Nucleus of Chemistry Students of the Associação Académica de Coimbra, with the theme "Chemistry: Bringing the Future Closer!" The main objective of this event was to provide information on the business market in Portugal. Meeting	V National Meeting of Chemistry Students Universidade de Coimbra Departamento de Química, Portugal

Association member

	Society Organization name	Role
2023/02/17 - Current	Fundação Infantil Ronald McDonald	Volunteer
2018/09 - 2020/09	Núcleo de Estudantes de Química da Associação Académica de Coimbra	Colaboradora no Pelouro da Pedagogia e Ciência