???global.info.a_carregar???
Joana Gaifem (JG) is a PhD researcher at Institute for Research and Innovation in Health (i3S), University of Porto. JG is graduated in Biology (2009) and master in Environmental Contamination and Toxicology (2011) by the University of Porto. Before enrolling a PhD JG worked for 3 years as a research fellow in Microbiology and Infection research projects. JG was admitted to the Interuniversity PhD Program in Aging and Chronic Diseases in 2015 at ICVS/UMinho working on microbiome factors contributing to protection/susceptibility in Inflammatory Bowel Disease (IBD). During PhD, JG was awarded with an EMBO Short-Term Fellowship to move as a visiting researcher at Universitätsklinikum Jena (Germany) and work on a biochip-based human gut model to assess microbiota impact in epithelial barrier. The PhD project allowed the first identification of a key microbiota signature that confers protection against IBD. The PhD was completed on March 2019. JG moved to i3S in November 2019 as a Post-Doc researcher working on the role of glycans in IBD immunopathogenesis and the crosstalk between glycans and intestinal microbiome. In 2020, JG was awarded with a contracted researcher position at the competitive Individual Call to Scientific Employment Stimulus - 3rd Edition, from Portuguese Foundation for Science and Technology (FCT). The work developed during her post-doc set the basis for several funded projects, such as the European funded project GlycanTrigger (HEurope). JG is currently PI of a ECCO Grants 2023. She was PI of an ESCMID research grants 2022). In 2024, JG was granted with the prestigious Maria de Sousa award, to study the host-microbiota interactions in IBD. In the host lab, JG was team member of a project funded by USA Department of Defense that aims to identify novel predictive biomarkers for IBD management (PREDICTS) and is currently part of the Horizon Europe-funded GlycanTrigger project. JG has supervised 1 PhD student and 1 MSc student, concluded in 2025 and 2021, respectively; she is currently supervising 2 PhD students and 1 research fellow. JG has a total of 25 publications (23 articles, 2 book chapters) and a h-index of 15.
Read full resume ↓
Identification

Personal identification

Full name
Joana Gaifem

Citation names

  • Gaifem, Joana

Author identifiers

Ciência ID
3B1A-4691-9DF1
ORCID iD
0000-0001-7306-7378

Email addresses

  • jgaifem@i3s.up.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 6082 (Professional)

Addresses

  • i3S – Institute for Research and Innovation in Health, Rua Alfredo Allen, 208 , 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Clinical Medicine - Gastroenterology and hepatology
  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2023/09/25 - 2023/10/24
Concluded
 Building and Leading Research Teams Course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/06/13 - 2023/06/29
Concluded
 Research Project Management, 3rd edition (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/10/25 - 2021/10/29
Concluded
 Introduction to Python and Machine Learning for the Biosciences, 2nd Edition (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01 - 2019/03/25
Concluded
 PhD in Aging and Chronic Diseases (Doutoramento)
Major in Chronic Diseases
Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis" (THESIS/DISSERTATION)
 Very Good (highest grade, approved unanimously)
2014/12/01 - 2014/12/12
Concluded
 FELASA C - Laboratory Animal Science (Outros)
Universidade do Minho Escola de Medicina, Portugal
2009 - 2011/10/28
Concluded
 Master in Environmental Contamination and Toxicology (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
"Role of Ncr1p in endoplasmic reticulum stress response in Saccharomyces cerevisiae" (THESIS/DISSERTATION)
 18 (out of 20)
2006 - 2009
Concluded
 Biology (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Ecotoxicological assays with estuarine cyanobacteria" (THESIS/DISSERTATION)
 14 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2021/05/01 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/11/15 - 2021/04/30 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/06/01 - 2019/11/14 Postdoc (Research) Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/03 - 2018/05 Visiting Researcher (Research) Universitätsklinikum Jena, Germany
Universitätsklinikum Jena - Center for Sepsis Control and Care, Germany
2011/10/01 - 2014/12/31 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Others

Category
Host institution 		Employer
2015/01/01 - 2019/03/25 PhD student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010/09 - 2011/10 Master student Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/09/01 - 2009/07/31 Undergraduate student (BSc) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Projects

Grant

Designation Funders
2015/01/01 - 2018/12/31 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis
PD/BD/106053/2015
PhD Student Fellow
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/01/01 - 2028/12/31 GLYCANS AS MASTER TRIGGERS OF HEALTH TO INTESTINAL INFLAMMATION TRANSITION
101093997
Researcher
Horizon 2020, Belgium
Ongoing
2021/05/01 - 2027/04/30 Glycans as dual regulatory elements in the crosstalk between microbiome and gut immune response: impact in IBD treatment
2020.00088.CEECIND/CP1608/CT0001
10.54499/2020.00088.CEECIND/CP1608/CT0001
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2025/01/01 - 2027/01/01 Feeding immunity: glycans as nutritional players in host-microbiome dynamics in IBD
Maria de Sousa Award 2024
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação Bial
Ongoing
2023/03/01 - 2025/03/31 Feeding immunity: development of a novel glycan-based dietary strategy for IBD prevention
IBDiet
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 European Crohn's and Colitis Organisation
Ongoing
2020/01/01 - 2024/12/31 Institute for Research and Innovation in Health
UIDB/04293/2020
10.54499/UIDB/04293/2020
LA/P/0070/2020
10.54499/LA/P/0070/2020
UIDP/04293/2020
10.54499/UIDP/04293/2020
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/04/01 - 2024/04/01 Glycans as the missing link to repair intestinal dysbiosis in Inflammatory Bowel Disease
-
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 European Society of Clinical Microbiology and Infectious Diseases
Concluded
2019/11/15 - 2024/03/29 Glycome as a predictor of IBD development
DoD
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 US Department of Defense
Concluded
2019/11/15 - 2021/04/30 Glycans in autoimmunity. Impact in the pathogenesis and treatment of Systemic Lupus Erythematosus
PTDC/MEC-REU/28772/2017
Post-doc Fellow
Unidade Local de Saúde de Coimbra EPE, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01 - 2021 Glycosylation in autoimmune hepatitis: identification of a novel non-invasive biomarker for diagnosis and prognosis
APEF/MSD
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Merck Sharp & Dohme (MSD)
Concluded
2020/01 - 2020/12 Design of a functional food supplement for a healthy gut
Researcher
Concluded
2020/04 - 2020/10 How sick will the coronavirus make you? The answer may be in your plasma IgG glycome signature
-
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2019/06/01 - 2019/11/14 Immunometabolic Networks in the Regulation of Visceral Leishmaniasis
Infect-ERA/0001/2016
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2018/07 - 2019/11 YoGut: a functional yogurt to prevent intestinal inflammation
NORTE-01-0246-FEDER-000043
Principal investigator
Universidade do Minho, Portugal
Concluded
2013/04/01 - 2014/12/31 A new approach to fight tuberculosis
HMSP-ICT/0024/2010
Research Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/10/01 - 2013/03/31 Secondary metabolites and nitrogen fixation of benthic marine Cyanobacteria: how different from freshwater relatives?
PTDC/MAR/102258/2008
Research Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Alves, Inês; Vicente, Manuel M.; Dias, Ana M.; Gaifem, Joana; Rodrigues, Cláudia; Campar, Ana; Pinho, Salomé S.. "The Role of Glycosylation in Inflammatory Diseases". In The Role of Glycosylation in Health and Disease, 265-283. Springer International Publishing, 2021.
    10.1007/978-3-030-70115-4_13
  2. Fernandes, Ângela; Dias, Ana M.; Silva, Mariana C.; Gaifem, Joana; Azevedo, Catarina M.; Carballo, Iago; Pinho, Salomé S.. "The Role of Glycans in Chronic Inflammatory Gastrointestinal and Liver Disorders and Cancer". In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2020.
    Published • 10.1016/b978-0-12-819475-1.00036-5
Conference abstract
  1. Brito, Â.; Gaifem, Joana (3B1A-4691-9DF1); Ramos, V.; Glukhov, E.; Dorrestein, P.C.; Gerwick, W.H.; Vasconcelos, V.M.; Mendes, M.V.; Tamagnini, P.. "Bioprospecting Portuguese Atlantic Coast Cyanobacteria for Bioactive Secondary Metabolites Reveals Untapped Chemodiversity". Paper presented in The 9th European Conference on Marine Natural Products, Glasgow, 2015.
    Published
Conference poster
  1. Castro, Raquel; Rodrigues, Cláudia S.; Leite-Gomes E; Pinho, Salomé S; Gaifem, Joana. "Glycosylation remodeling at the gut mucosa: an organoid strategy to tackle Inflammatory Bowel Disease". Paper presented in MET-CONF24 - Metainflammation: a hot topic in metabolic dysfunction, 2024.
  2. Gaifem, Joana; Rodrigues, Cláudia; Petralia, Francesca; Alves, Inês; Leite-Gomes E; Cavadas, Bruno; Dias, Ana Mendes; et al. "Alterations in serum IgG glycome are associated with Crohn’s Disease development". Paper presented in 7th European Congress of Immunology, 2024.
  3. Mendes-Frias, Ana; Vieira, Maria C.; Araújo, Marta; Micheli, Consuelo; Duarte, Iola F.; Gaifem, Joana; Torrado, Egídio; et al. "Branched-Chain Amino Acids in Ulcerative Colitis: friend or foe?". Paper presented in XLIX Annual Meeting of the Portuguese Society for Immunology,, 2024.
  4. Mendes-Frias, Ana ; Vieira, Maria C.; Araújo, Marta; Micheli, Consuelo; Gaifem, Joana; Torrado, Egídio; Lopes, Luís; Silvestre, Ricardo. "Unraveling the dynamic effect of branched-chain amino acids in the gut: the influence of sex". Paper presented in EMBO Young Scientists' Forum, 2023.
  5. Gaifem, Joana; Rodrigues, Cláudia S.; Tavares-Gomes, Leticia; Alves, Maria Francisca; Pereira, Márcia S. ; Sokol, Harry; Pinho, Salomé S. "Host glycosylation shapes gut immunity and intestinal microbiome – a central player in Inflammatory Bowel Disease". Paper presented in Sialoglycans in Development and Immunity, 2023.
  6. Mendes-Frias, Ana; Vieira, Maria C.; Araújo, Marta; Micheli, Consuelo; Gaifem, Joana; Torrado, Egídio; Lopes, Luís; Silveste, Ricardo. "Unraveling the dynamic effect of branched-chain amino acids in the gut". Paper presented in Retreat for postgraduate students at the School of Medicine, 2023.
  7. Rodrigues, Cláudia; Gaifem, Joana; Alves, Maria Francisca; Pereira, Márcia S.; Lago, Paula; Harry Sokol; Pinho, Salomé. "Host glycosylation shapes intestinal microbiome and immune response in Inflammatory Bowel Disease". Paper presented in 12th European Mucosal Immunology Group Meeting, 2023.
  8. Rodrigues, Cláudia; Gaifem, Joana; Pereira, Márcia S.; Aonghus Lavelle ; J. F. Colombel; Sokol, Harry; Pinho, Salomé. "Glycans as an actor in the microbiome-immune response crosstalk.". Paper presented in 18th Congress of ECCO - Inflammatory Bowel Diseases 2023, 2023.
  9. Gaifem, Joana; Rodrigues, Cláudia; Alves, Maria Francisca; Pereira, Márcia; Sokol, Harry ; Lago, Paula; Pinho, Salomé S. Corresponding author: Gaifem, Joana. "Host glycosylation shapes gut immunity via modulation of intestinal microbiome". Paper presented in New Frontiers symposium on Translational Glycoscience, 2021.
  10. Mendes-Frias, Ana ; Gaifem, Joana; Lopes, Luís; Silvestre, Ricardo. "Unraveling the dinamic effect of Branched Chain Amino Acids in the gut". Paper presented in Annual Meeting of Portuguese Society of Immunology (online), 2021.
  11. Gaifem, Joana; Gonçalves, L.G.; Dinis-Oliveira, R.J.; Cunha, C.; Carvalho, A.; Torrado, E.; Rodrigues, F.; et al. "L- Threonine supplementation during colitis onset delays disease". Paper presented in 5th European Congress of Immunology 2018, 2018.
  12. Gaifem, Joana; Garzon, M.J.; Ubeda, C.; Gonçalves, L.G.; Longatto-Filho, A.; Belinha, A.; Mesquita, I.; et al. "Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis.". Paper presented in 5th European Congress of Immunology 2018., 2018.
  13. Gaifem, Joana; Gonçalves, L.G; Dinis-Oliveira, R.J.; Cunha, C.; Carvalho, A.; Torrado, E.; Rodrigues, F.; et al. "L- Threonine supplementation during colitis onset delays disease". Paper presented in XLIV Annual Meeting of the Portuguese Society for Immunology, 2018.
  14. Gaifem, Joana; Garzón, MJ; Ubeda, C; Gonçalves, LG; Longatto-Filho, A; Belinha, A; Mesquita, I; et al. "Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis.". Paper presented in TOLL 2018, Editing Innate Immunity., 2018.
  15. Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Rodrigues, Cláudia S.; Gonçalves, Samuel M.; Gaifem, Joana; Mesquita, Inês; Garlanda, Cecilia; et al. "Pentraxin-3 promotes IL-10-dependent immune protection to the oppurtunistic fungus Trichosporon asahii". Paper presented in XLIII SPI Annual Meeting, 2018.
  16. Gonçalves, Samuel M.; Rodrigues, Cláudia S.; Campos, Cláudia F.; Duarte-Oliveira, Cláudio; Gaifem, Joana; van de Veerdonk, Frank L.; Campos Jr., António; et al. "Genetically-determined NLRP3 hyperactivation confers risk to fungal disease by compromising macrophage function". Paper presented in XLIII SPI Annual Meeting, 2018.
  17. Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Rodrigues, Cláudia S.; Gonçalves, Samuel M.; Gaifem, Joana; Barbosa, Ana M.; Ferreira, Catarina R.; et al. "IL-10 overexpression in vivo promotes susceptibility to aspergillosis by supressing innate and adaptive pulmonary antifungal immunity". Paper presented in 8th Advances Against Aspergillosis, 2018.
  18. Gaifem, Joana; Gonçalves, Luis Gafeira; Dinis-Oliveira, R; Cunha, Cristina; Carvalho, Agostinho; Torrado, Egidio; Rodrigues, Fernando; et al. "L- Threonine supplementation during colitis onset delays disease". Paper presented in XLIV Annual Meeting of the Portuguese Society for Immunology, 2018.
  19. Gaifem, Joana; Garzon, MJ; Ubeda, C; Gonçalves, LG; Longatto-Filho, A; Belinha, A; Mesquita, I; et al. "DECIPHERING THE MICROBIOME AND METABOLIC FACTORS CONTRIBUTING TO PROTECTION AGAINST ULCERATIVE COLITIS". Paper presented in TOLL 2018, Editing Innate Immunity., 2018.
  20. Gaifem, Joana; Garzon, MJ; Ubeda, C; Gonçalves, LG; Longatto-Filho, A; Belinha, A; Mesquita, I; et al. "DECIPHERING THE MICROBIOME AND METABOLIC FACTORS CONTRIBUTING TO PROTECTION AGAINST ULCERATIVE COLITIS". Paper presented in 5th European Congress of Immunology 2018., 2018.
  21. Gaifem, Joana; Correia, Clara R.; Oliveira, Mariana B.; Silvestre, Ricardo; Mano, João F.. "The influence of surface modified poly(L-lactic acid) films on the differentiation of human monocytes into macrophages.". Paper presented in XLIII Annual Meeting of the Portuguese Society for Immunology, 2017.
  22. Correia, Clara R.; Gaifem, Joana; Oliveira, Mariana B.; Silvestre, Ricardo; Mano, João F.. "Influence of surface modified poly(L-lactic acid) films on the differentiation of human monocytes into macrophages". Paper presented in Tissue Engineering and Regenerative Medicine International Society - European Chapter Meeting (TERMIS-EU), 2017.
  23. Gaifem, Joana; Araújo, Andreia; Belinha, Ana; Mesquita, Inês; Gonçalves, Luís; Santos, Sophia; Torrado, Egídio; et al. "Immunometabolic characterization of the intestinal mucosa upon chemically-induced colitis in mice from different animal facilities". Paper presented in Summer Frontiers 2016 – Systems Biology of Innate Immunity, 2016.
  24. Gaifem, Joana; Araujo, A; Belinha, A; Mesquita, I; Gonçalves, LG; Santos, S; Torrado, E; et al. "Immunometabolic characterization of the intestinal mucosa upon chemically-induced colitis in mice from different animal facilities". Paper presented in Summer Frontiers - Systems Biology of Innate Immunity, 2016.
  25. Gaifem, Joana; Vilaça, Rita; Costa, Vítor. "Role of NCR1 in endoplasmic reticulum stress response in yeast". Paper presented in i3S Scientific Retreat, 2011.
Journal article
  1. Rodrigues, Cláudia S.; Gaifem, Joana; Pereira, Márcia S.; Alves, Maria Francisca; Silva, Mariana; Padrão, Nuno; Cavadas, Bruno; et al. "Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation". Gut Microbes 17 1 (2025): https://doi.org/10.1080/19490976.2025.2461210.
    Published • 10.1080/19490976.2025.2461210
  2. Gaifem, Joana; Rodrigues, Cláudia S.; Petralia, Francesca; Alves, Inês; Leite-Gomes, Eduarda; Cavadas, Bruno; Dias, Ana M.; et al. "A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan". Nature Immunology 25 9 (2024): 1692-1703. http://dx.doi.org/10.1038/s41590-024-01916-8.
    10.1038/s41590-024-01916-8
  3. Mendes-Frias, Ana; Moreira, Marta; Vieira, Maria C.; Gaifem, Joana; Costa, Patrício; Lopes, Luís; Silvestre, Ricardo. "Akkermansia muciniphila and Parabacteroides distasonis as prognostic markers for relapse in ulcerative colitis patients". Frontiers in Cellular and Infection Microbiology 14 (2024): http://dx.doi.org/10.3389/fcimb.2024.1367998.
    10.3389/fcimb.2024.1367998
  4. Crouch, Lucy I.; Rodrigues, Cláudia S.; Bakshani, Cassie R.; Tavares-Gomes, Leticia; Gaifem, Joana; Pinho, Salomé S.. "The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system". Seminars in Immunology 73 (2024): 101891. http://dx.doi.org/10.1016/j.smim.2024.101891.
    10.1016/j.smim.2024.101891
  5. Gaifem, Joana; Mendes-Frias, Ana; Wolter, Mathis; Steimle, Alex; Garzón, Maria Jose; Ubeda, Carles; Nobre, Clarisse; et al. "Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut". mBio 15 4 (2024): http://dx.doi.org/10.1128/mbio.00078-24.
    10.1128/mbio.00078-24
  6. Pinho, Salomé S.; Alves, Inês; Gaifem, Joana; Rabinovich, Gabriel A.. "Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection". Cellular & Molecular Immunology (2023): http://dx.doi.org/10.1038/s41423-023-01074-1.
    10.1038/s41423-023-01074-1
  7. Domingues, Neuza; Gaifem, Joana; Matthiesen, Rune; Saraiva, Diana P.; Bento, Luís; Marques, André R.A.; Soares, Maria I.L.; et al. "Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation". Journal of Lipid Research (2023): 100419. http://dx.doi.org/10.1016/j.jlr.2023.100419.
    10.1016/j.jlr.2023.100419
  8. Mortha, Arthur; Remark, Romain; Del Valle, Diane Marie; Chuang, Ling-Shiang; Chai, Zhi; Alves, Inês; Azevedo, Catarina; et al. "Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn’s Disease". Gastroenterology 163 3 (2022): 659-670. http://dx.doi.org/10.1053/j.gastro.2022.05.029.
    10.1053/j.gastro.2022.05.029
  9. Vicente, Manuel M.; Alves, Inês; Gaifem, Joana; Rodrigues, Cláudia S.; Fernandes, Ângela; Dias, Ana M.; Štambuk, Jerko; et al. "Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity". European Journal of Immunology 52 6 (2022): 946-957. http://dx.doi.org/10.1002/eji.202149491.
    10.1002/eji.202149491
  10. Alves, Inês; Vicente, Manuel Machado; Gaifem, Joana; Fernandes, Ângela; Dias, Ana Mendes; Rodrigues, Cláudia Sousa; Oliveira, José Carlos; et al. "SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis". The Journal of Immunology (2021): ji2100131. http://dx.doi.org/10.4049/jimmunol.2100131.
    10.4049/jimmunol.2100131
  11. Petrovic, T; Alves, I; Bugada, D; Pascual, J; Vuckovic, F; Skelin, A; Gaifem, Joana; et al. "Composition of the immunoglobulin G glycome associates with the severity of COVID-19". Glycobiology (2020): http://dx.doi.org/10.1093/glycob/cwaa102.
    Published • 10.1093/glycob/cwaa102
  12. de Sousa Gonçalves, Rafaela; Alves de Pinho, Flaviane; Dinis-Oliveira, Ricardo Jorge; Azevedo, Rui; Gaifem, Joana; Larangeira, Daniela Farias; Ramos-Sanchez, Eduardo Milton; et al. "Mathematical Modelling Using Predictive Biomarkers for the Outcome of Canine Leishmaniasis upon Chemotherapy". Microorganisms 8 5 (2020): 745. http://dx.doi.org/10.3390/microorganisms8050745.
    10.3390/microorganisms8050745
  13. Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, Toine; et al. "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-16120-z.
    10.1038/s41467-020-16120-z
  14. Mendes-Frias, Ana; Santos-Lima, Bruno; Sousa Furtado, Danielle Zildeana; Ruperez, Francisco J.; Assunção, Nilson Antonio; Matias, Maria João; Gomes, Vânia; et al. "Dysregulation of glycerophospholipid metabolism during Behçet's disease contributes to a pro-inflammatory phenotype of circulating monocytes". Journal of Translational Autoimmunity (2020): 100056. http://dx.doi.org/10.1016/j.jtauto.2020.100056.
    10.1016/j.jtauto.2020.100056
  15. Gressler, M.; Heddergott, C.; N'Go, I.C.; Renga, G.; Oikonomou, V.; Moretti, S.; Coddeville, B.; et al. "Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus". Frontiers in Cellular and Infection Microbiology 9 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075187565&partnerID=MN8TOARS.
    10.3389/fcimb.2019.00365
  16. Gaifem, J.; Gonçalves, L.G.; Dinis-Oliveira, R.J.; Cunha, C.; Carvalho, A.; Torrado, E.; Rodrigues, F.; et al. "L-threonine supplementation during colitis onset delays disease recovery". Frontiers in Physiology 9 SEP (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053078274&partnerID=MN8TOARS.
    10.3389/fphys.2018.01247
  17. Correia, C.R.; Gaifem, J.; Oliveira, M.B.; Silvestre, R.; Mano, J.F.. "The influence of surface modified poly(L-lactic acid) films on the differentiation of human monocytes into macrophages". Biomaterials Science 5 3 (2017): 551-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014175882&partnerID=MN8TOARS.
    10.1039/c6bm00920d
  18. Cunha, C.; Gonçalves, S.M.; Duarte-Oliveira, C.; Leite, L.; Lagrou, K.; Marques, A.; Lupiañez, C.B.; et al. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity". Journal of Allergy and Clinical Immunology 140 3 (2017): 867-870.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019152778&partnerID=MN8TOARS.
    10.1016/j.jaci.2017.02.034
  19. Mesquita, I.; Varela, P.; Belinha, A.; Gaifem, J.; Laforge, M.; Vergnes, B.; Estaquier, J.; Silvestre, R.. "Exploring NAD+ metabolism in host-pathogen interactions". Cellular and Molecular Life Sciences 73 6 (2016): 1225-1236. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958779817&partnerID=MN8TOARS.
    10.1007/s00018-015-2119-4
  20. Moreira-Teixeira, L.; Sousa, J.; McNab, F.W.; Torrado, E.; Cardoso, F.; Machado, H.; Castro, F.; et al. "Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-¿ signaling". Journal of Immunology 197 12 (2016): 4714-4726. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002328285&partnerID=MN8TOARS.
    10.4049/jimmunol.1600584
  21. Cruz, A.; Ludovico, P.; Torrado, E.; Gama, J.B.; Sousa, J.; Gaifem, J.; Appelberg, R.; et al. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Frontiers in Immunology 6 SEP (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946550863&partnerID=MN8TOARS.
    10.3389/fimmu.2015.00498
  22. Brito, Â.; Gaifem, J.; Ramos, V.; Glukhov, E.; Dorrestein, P.C.; Gerwick, W.H.; Vasconcelos, V.M.; Mendes, M.V.; Tamagnini, P.. "Bioprospecting Portuguese Atlantic coast cyanobacteria for bioactive secondary metabolites reveals untapped chemodiversity". Algal Research 9 (2015): 218-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928655852&partnerID=MN8TOARS.
    10.1016/j.algal.2015.03.016
  23. Vilaça, R.; Silva, E.; Nadais, A.; Teixeira, V.; Matmati, N.; Gaifem, J.; Hannun, Y.A.; Sá Miranda, M.C.; Costa, V.. "Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1". Molecular Microbiology 91 3 (2014): 438-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908101723&partnerID=MN8TOARS.
    10.1111/mmi.12470
Thesis / Dissertation
  1. Gaifem, Joana. "Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis". PhD, Universidade do Minho Escola de Medicina, 2019.
  2. Gaifem, Joana. "Role of Ncr1p In Endoplasmic Reticulum Stress Response In Saccharomyces cerevisiae". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2011. http://hdl.handle.net/10216/56926.

Intellectual property

Patent
  1. Gaifem, Joana; Pinho, Salomé S. 2024. "Provisional Patent Application".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10/25 Changes in the glycosylation of circulating IgG predict future Crohn’s disease onset MET-CONF24 - Metainflammation: a hot topic in metabolic dysfunction
Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2023/10/17 Glycans: a novel dietary strategy to prevent Inflammatory Bowel Disease? (Glicanos: uma nova estratégia nutricional para a prevenção da Doença Inflamatória Intestinal?) Jornadas da Dietética e Nutrição
Escola Superior de Saúde - Instituto Politécnico de Leiria (Leiria, Portugal)
2019/11/10 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis Minho Medical Meeting 2019 - XII Edition
Universidade do Minho - NEMUM (Braga, Portugal)
2017/06/15 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis XLIII Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Porto, Portugal)
2017/06 Deciphering the microbiome and metabolic factors contributing to protection against ulcerative colitis ICVS Open Day
ICVS/UMinho (Braga, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/01/01 - Current Understanding the biological impact of changes in gut mucosa glycome in microbial and immunological dynamics: impact in health to intestinal inflammation transition
Co-supervisor of Mariana Castro Sousa
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/08/01 - Current GLICOPEDII - Glycosylation as new molecular mechanism underlying Pediatric Inflammatory Bowel Disease
Co-supervisor of Ana Rita Gonçalves Amorim
 Ciência de Dados de Saúde (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2020/10/01 - 2025/02/14 Glycans as dual orchestrators of microbiome and immune response in Inflammatory Bowel Disease pathogenesis: impact in new therapeutic strategies
Co-supervisor of Cláudia Rodrigues
 Ciências Biomédicas (PhD)
Universidade do Porto, Portugal
2021/09 - 2022/06 The role of N-Glycosylation in the development of Inflammatory Bowel Disease
Supervisor of António Pinto
Colégio Internato dos Carvalhos, Portugal
2020/09/01 - 2021/11/26 Glycans as dual players of intestinal microbiome and immune response: impact in Inflammatory Bowel Disease immunopathogenesis
Co-supervisor of Maria Francisca Ribeiro Alves
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2019/02 - 2019/06 Dissecting the role of succinate in ulcerative colitis: effect on gut epithelial barrier and microbiota
Co-supervisor of Ana Isabel Mendes Frias
 PhD Health Sciences - laboratory rotation (PhD)
Universidade do Minho Escola de Medicina, Portugal
2017/02 - 2017/03 Immunometabolic characterization of mice intestinal mucosa upon chemically-induced colitis
Co-supervisor of Nuno Ricardo Lucas Soares
 PhD Aging and Chronic Diseases - laboratory rotation (PhD)
Universidade do Minho Escola de Medicina, Portugal
2017/02 - 2017/03 Immunometabolic characterization of mice intestinal mucosa upon chemically-induced colitis
Co-supervisor of Andreia Cristiana Sousa Barbosa
 MSc in Health Sciences - laboratory rotation (Master)
Universidade do Minho Escola de Medicina, Portugal
2016/02 - 2016/07 Immunopathological characterization of chemically induced colitis in mice from different animal houses
Co-supervisor of Andreia Araújo
Laboratório Associado ICVS 3B's, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/03/25 - 2019/03/29 Collaborator in the Microbiology and Infection Open Week (event open to general communities to contact with scientific questions) (2019/03/25 - 2019/03/29)
Other
 Universidade do Minho Escola de Medicina, Portugal
2014/04/11 - 2014/04/11 Hematopoiesis: from bench to bedside (2014/04/11 - 2014/04/11)
Workshop (Member of the Organising Committee)
 Universidade do Minho, Portugal
2012/08/05 - 2012/08/10 14th International Symposium on Phototrophic Prokaryotes (2012/08/05 - 2012/08/10)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Association member

Society Organization name Role
2022/07/22 - Current European Crohn's and Colitis Organisation (ECCO) Associate
2019/09 - Current European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Associate
2014/01 - Current Portuguese Society for Immunology (SPI) Associate

Committee member

Activity description
Role 		Institution / Organization
2023/10 - Current Representative of the i3S PhD researchers
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2018 Vice-representative for the students from the Interuniversity PhD Program in Ageing and Chronic Diseases
President / Vice-president
 Universidade do Minho Escola de Medicina, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/02/10 - 2014/02/21 A hands-on approach to cell and tissue culture: from cell isolation, manipulation and characterization to advanced microscopy. Health Sciences (Mestrado) Universidade do Minho Escola de Medicina, Portugal

Interview (tv / radio show)

Program Topic
2020/09/10 - Current 90 Segundos de Ciência (90 sec of Science) Biomarkers for prediction of COVID-19 severity

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Frontiers in Immunology (1664-3224) Frontiers Media SA

Mentoring / Tutoring

Topic Student name
2023/01/01 - 2025/03/31 Feeding immunity: development of a novel glycan-based dietary strategy for IBD prevention Raquel Faria de Castro
2020/01 - 2021/12 Glycosylation in autoimmune hepatitis: identification of a novel non-invasive biomarker for diagnosis and prognosis Iago Carballo Fernández (MD/PhD)
2020/02 - 2020/09 Glycans as modulators of intestinal microbiome - impact in IBD Cláudia Rodrigues (MSc)
2019/02 - 2019/04 Microbiota and metabolic factors in Ulcerative Colitis Ana Raquel Carvalho Bertão (PhD student)
2017/02/07 - 2017/03/10 Immunometabolic characterization of mouse intestinal mucosa upon chemically-induced colitis Tiago Xavier Silva Ribeiro (MSc student)
2014/03 - 2014/04 Immunology: Macrophage infection (BSc curricular training) Inês Pinheiro (BSc student)
Distinctions

Award

2024 Prémio Maria de Sousa - Maria de Sousa Award
Fundação Bial, Portugal

Ordem dos Médicos, Portugal
2019 Innovation Projects in Traditional Food Products | FoodValorization and NewFood
2018 EMBO Short-Term Fellowship
EMBO - European Molecular Biology Organization , Germany
2018 EFIS Acteria Travel Grant
European Federation of Immunological Societies, Germany
2017 SPI Travel Grant
Sociedade Portuguesa de Imunologia, Portugal