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Célia Fernandes (CF) is a Principal Researcher at the Department of Nuclear Sciences and Engineering (DECN) and member of the Centre for Nuclear Sciences and Technologies (C2TN) of the Instituto Superior Técnico, ULisboa. She concluded a PhD in Pharmacy (Pharmaceutical Chemistry) at the Faculty of Pharmacy, ULisboa in February 2009, with a thesis focusing the development of specific radiopharmaceuticals. Her main scientific activity is focused on the design and development of target-specific radiometallated compounds interesting for nuclear molecular imaging, targeted therapy and/or theranostics. She is involved essentially in organic, inorganic and organometallic chemistry and radiochemistry, aiming to introduce synthetic strategies for the development of new radiopharmaceuticals. She explores block copolymer micelles for the simultaneous delivery of cytotoxic drugs and radiation for image-guided drug delivery and cancer therapy. She was Invited Adviser for the IAEA Consultants Meeting (CM) April 2022, with the title of "IAEA Future Activities on Tc-99m Kits and Radiopharmaceuticals". The meeting focus the planning, aims and scope of a possible IAEA Coordinated Research Project (CRP) on "Development and application of new Tc-99m Kits and Radiopharmaceuticals". CF has been the coordinator of 1 project funded by the FCT and Co-PI of a UT Austin-Portugal research project "Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer" (https://utaustinportugal.org/projects/ther-pbct/). CF participate or has participated as a team member in 8 other projects funded by the FCT, team member of 1 project funded by Phospholipid Research Center and team member of 1 project funded by Proyectos de I+D+i», Spain (coordinated by Prof. Ezequiel M. Vázquez López; Universidade de Vigo). She is author of more than 60 papers published in peer-reviewed international journals and more than 20 proceedings or conference papers and more than 100 communications in national and international conferences. CF supervised 1 PhD thesis, supervised 6 MSc dissertations, 10 students from 1st cycle Integrator Project (IST) and several BI students. Currently CF is supervising 2 PhD students, 3 Master students and 2 students in 1st cycle Integrator Project (IST).
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Identification

Personal identification

Full name
Célia Fernandes

Citation names

  • Fernandes, Célia

Author identifiers

Ciência ID
3B1A-E650-A59E
ORCID iD
0000-0002-2119-8293

Knowledge fields

  • Exact Sciences - Chemical Sciences - Nuclear Chemistry
  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2009
Concluded
 Farmácia - química Farmacêutica (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Complexos de Re e Tc e Compostos Iodados Relevantes para a Concepção de Radiofármacos" (THESIS/DISSERTATION)
 PhD with honours
1999
Concluded
 Mestrado em Química Farmacêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Complexos de 99mTc com aminoácidos e dipéptidos- uma nova abordagem de marcação" (THESIS/DISSERTATION)
 Muito Bom
Affiliation

Science

Category
Host institution 		Employer
2023/11/01 - Current Principal Investigator (Research) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Projects

Contract

Designation Funders
2023 - Current Improved 177Lu radioconjugates for Prostate Cancer Theranostics - development and evaluation in advanced cellular models
CRPF-22078
Researcher
International Atomic Energy Agency, Austria
Ongoing
2023 - Current B/Fe/Au Multifunctional Nanoplatforms for Proton/Photon Therapy: Imaging and Irradiation Using Cancer Cell Models
CRP F11024
Researcher
International Atomic Energy Agency, Austria
2024 - 2029 Development of novel 99mTc-Radiopharmaceuticals for Prostate Cancer Theranostics
CRP F22077
Principal investigator
Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Ongoing
2022/01/02 - 2025/01/01 Development of potent and broadly neutralizing antibodies fragments for COVID-19 derived from domestic cats naturally infected with SARS
PTDC/CVT-CVT/0149/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/02 - 2025/01/01 Development of potent and broadly neutralizing antibodies fragments for COVID-19 derived from domestic cats naturally infected with SARS-CoV-2
PTDC/CVT-CVT/0149/2021
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/29 - 2024/03/28 Novel nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes
PTDC/QUI-QIN/0586/2020
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2023/12/31 Radiocomplexos Dirigidos a Organelos Celulares para Terapia Auger do Cancro
PTDC/MED-QUI/1554/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Centro de Ciências e Tecnologias Nucleares, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/04 - 2023/03 Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer
UTAP-EXPL/FMT/0020/2021
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Centre for Nuclear Sciences and Technologies
UID/Multi/04349/2019
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/06 - 2016/05 Molecular and Nano Tools for Cancer Theranostics
Provided by PTCRIS: 126789
EXCL/QEQ-MED/0233/2012
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Aveiro, Portugal

Universidade de Coimbra, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2014/04 - 2015/07 Dual Targeting Strategy for EGFR Positive Tumors
Provided by PTCRIS: 134975
EXPL/QEQ-MED/1950/2013
Principal investigator
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2011/04 - 2014/10 Synthesis and Pre-clinical Evaluation of Novel Estradiol-Based Indium Complexes for Targeted Radiotherapy of Tumors
Provided by PTCRIS: 111891
PTDC/QUI-QUI/111891/2009
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 Albumin binding-domain fusions to improve protein pharmacokinetics
PTDC/SAU-FAR/115846/2009
Provided by PTCRIS: 115846
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluded
Outputs

Publications

Book
  1. Andrea Santos; Luisa Roldao Pereira; Paolo Turco; Erik Rosa-Rizzotto; Diego Caroli; Alessandro Gubbiotti; Lurdes Gano; et al. Gastrointestinal Molecular Imaging. 2023.
    10.52717/IJDW6277
Book chapter
  1. Paulo, António; Gano, Lurdes; Fernandes, Célia. Corresponding author: Gano, Lurdes. "Radiopharmaceuticals for Gastrointestinal Imaging". In Gastrointestinal Molecular Imaging. Austria, 2023.
Conference abstract
  1. Fernandes, Célia; Gano, Maria Lurdes; Vultos, Filipe; Mendes, Filipa; Correia, JDG. "Biological evaluation of radiolabelled peptides for oestrogen positive tumour theranostics". Paper presented in Annual Congress of the European Association of Nuclear Medicine, Barcelone, 2019.
  2. Paulo, António; Fernandes, Célia; Filipa, Mendes; Do Quental, Letícia; Raposinho, Paula; Vaz, Pedro; DiMaria, Salvatore. "Radiobiological and Dosimetric Assessment of DNA-Targeted 99mTc(I) Complexes". Paper presented in NOVA BIOPHYSICA International Congress, Lisboa, 2019.
  3. Vultos, F.; Belo M; Scheepstra M; Francisco Silva; Fernandes, Célia; C. Oliveira; Mendes, Filipa; et al. "Biological Assessment of a Radiolabelled LXXLL-Peptide for Breast Cancer Theranostics". Paper presented in ESRR’18 – 19th European Symposium on Radiopharmacy and Radiopharmaceuticals,, Groningen, 2018.
    Published
  4. Neto, C.; Oliveira, MC; Fernandes, Célia; Gano, Lurdes; Mendes, Filipa; Kniess, T.; Santos, I.. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". Paper presented in Paper presented in 19th International Symposium on Radiopharmaceutical Sciences, 2011.
    Published
  5. Gano, Lurdes; Mendes, Filipa; Fernandes, Célia; Paulo, António; Santos, I.. "Biological Evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection". Paper presented in 15th European Symposium on Radiopharmacy and Radiopharmaceuticals, Edinburgh, 2010.
    Published
  6. Mendes, Filipa; Gano, L; Fernandes, Célia; Paulo, António; Santos, I.. "Evaluation of 99mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance". Paper presented in Annual Congress of the EANM, Viena, 2010.
    Published
Conference paper
  1. Fernandes, Célia; Joana Santos; Braz, Maria Teresa; Francisco Silva; Raposinho, P; Joana Guerreiro; Frederik Cleeren; et al. "Mitochondria-targeted radiocomplexes for cancer theranostics". Paper presented in in TERACHEM 2022: Fourth InternationalSymposium on Technetium and Other Radiometals in Chemistry andMedicine, Bressanone, 2022.
    Published
  2. S.Cunha; F.Vultos; Fernandes, Célia; C. Bernhard; F. Marques; F. Denat; I. Santos; L.Gano. "Novel 111In-estradiol based complexes for oestrogen receptor targeting". Paper presented in 17th European Symposium on Radiopharmacy and Radiopharmaceuticals (ESRR'14), Pamplona, 2014.
    Published
  3. F.Vultos; S.Cunha; Fernandes, Célia; L.Gano; I. Santos. "Estradiol based indium complexes towards the estrogen receptor". Paper presented in ISMEC2012 International Symposia on Metal Complexes, Lisboa, 2012.
    Published
  4. S. Cunha; L. Gano; Fernandes, Célia; A. Paulo; I. Santos. "99mTc(I) Cationic complexes for tumoral detection". Paper presented in 8th. International Symposium Technetium, Rhenium and other Metals in Chemistry and Nuclear Medicine, Bressanone, 2010.
    Published
  5. Fernandes, Célia; L. Gano; A. Bourkoula; I. Pirmettis; I. Santos. "Novel Re(I)/99mTc(I) Tricarbonyl Complexes Bearing Quinazoline Moiety as Biomarkers for Epidermal Growth Factor Receptor Positive Tumors". Paper presented in 7th. International Symposium Technetium, Rhenium and other Metals in Chemistry and Nuclear Medicine, Bressanone, 2006.
    Published
  6. C. Moura; Fernandes, Célia; L. Gano; A. Paulo; I. Santos. "Rhenium (I) and 99mTechnetium (I) Tricarbonyl Complexes Anchored by Monoanionic Pyrazolyl-Based Chelators". Paper presented in 7th. International Symposium Technetium, Rhenium and other Metals in Chemistry and Nuclear Medicine, Bressanone, 2006.
    Published
  7. N. Margaritis; A. Bourkoula; A. Chiotellis; A. Papadopoulos; A. Panagiotopoulou; C. Tsoukalas; Fernandes, Célia; et al. "A New Technetium-99m Biomarker for EGFR-TK". Paper presented in 7th. International Symposium Technetium, Rhenium and other Metals in Chemistry and Nuclear Medicine, Bressanone, 2006.
    Published
  8. Fernandes, Célia; Santos, Isabel. "Synthesis of Quinazoline Derivatives: Coupling to different Chelators, Labelling with Different 99mTc Cores and in Vitro and in Vivo Evaluation". Paper presented in 2nd Research Co-ordination Meeting (RCM) on Development of 99mTc Based Small Biomolecules Using Novel 99mTc Cores, 2005.
    Published
  9. Fernandes, Célia; T. Kniess; I. Santos; S. Seifert; H. Spies; A. Zablotskaya. "Synthesis of Hydroxyl Silylated Rhenium and (99mTc)Technetium '3+1' Oxo-Complexes With The H2PNS Tridentate Ligand". Paper presented in 6th. International Symposium Technetium, Rhenium and other Metals in Chemistry and Nuclear Medicine, Bressanone, 2002.
    Published
Conference poster
  1. Joana Santos; Fernandes, Célia; Raposinho, Paula; Mendes, Filipa; Sandra Mota; Paulo Oliveira; António Manuel Rocha Paulo. "Metalloconjugates designed to target the mitochondria of prostate cancer cells: design, synthesis and evaluation as theranostic agents". Paper presented in IV Metabolism, Ageing & Disease (MAD) Meeting Disease & Therapeutics: from the Past to Future, 2024.
  2. Joana Santos; Raposinho, Paula; Fernandes, Célia; Mendes, Filipa; Sandra Mota; Paulo Oliveira; António Manuel Rocha Paulo; Ana M. Urbano. "Design, synthesis and evaluation as theranostics agents of novel metalloconjugates targeted at the mitochondria of prostate cells". Paper presented in Ambiente, Genética e Oncobiologia no Século XXI - Desafios e Oportunidades, 2024.
  3. joana santos; Fernandes, Célia; Raposinho, Paula; Mendes, Filipa; Sandra Mota; Paulo Oliveira; António Manuel Rocha Paulo. "Biological e valuation of novel dually t arget ed metallo conjugates c ontaining a PSMA i nhibitor and a TPP g roup for prostate cancer theranostics". Paper presented in Mitochondria in Aging, Cancer and Cell Death (MAC 2023), 2023.
  4. Joana Santos; Fernandes, Célia; Mendes, Filipa; Raposinho, Paula; Ana M. Urbano; Sandra Mota; Paulo Oliveira; António Manuel Rocha Paulo. "Avaliação biológica em modelos celulares de cancro da próstata de radioconjugados de duplo alvo contendo um grupo trifenil-fosfónio (TPP) e um inibidor do PSMA". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  5. Joana Santos; Fernandes, Célia; Raposinho, Paula; Mendes, Filipa; Ana M. Urbano; Sandra Mota; Paulo Oliveira; António Manuel Rocha Paulo. "Dually-targeted radioconjugates carrying TPP and a PSMA-binding moiety: biological studies in prostate cancer models". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, 2023.
  6. Joana Santos; Fernandes, Célia; Raposinho, Paula; Mendes, Filipa; Ana M. Urbano; Sandra Mota; Paulo Oliveira; António Paulo. "Biological evaluation of dual-targeted radioconjugates carrying TPP and PSMA-binding moieties on prostate cancer models". Paper presented in 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023.
  7. Santos, Joana F.; Fernandes, Célia; Braz, Maria Teresa; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Cleeren, Frederik; et al. "Dual-targeted 111In-Radiocomplexes for Auger Therapy of Prostate Cancer". Paper presented in International Symposium on Trends in Radiopharmaceuticals, 2023.
  8. Mendes, Filipa; Fernandes, Célia; Santos, Joana F.; Maria Teresa Braz; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; et al. "Dual-targeted 111In and 161Tb Complexes for Radionuclide Therapy ofProstate Cancer". Paper presented in The 2nd International Workshop onRadiobiology of Molecular Radionuclide Therapy, 2023.
  9. Fernandes, Célia; Santos, Joana F.; Maria Teresa Braz; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Frederik Cleeren; António Paulo. Corresponding author: António Paulo. "Mitochondrion-Tropic Radioconjugates Carrying TPPand PSMA Derivatives: Radiobiological and Imaging Studies in Prostate CancerModels". Paper presented in WMIC 2022: World Molecular Imaging Congress, 2022.
  10. Fernandes, Célia; Santos, Joana F.; Maria Teresa Braz; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Frederik Cleeren; António Paulo. Corresponding author: Fernandes, Célia. "Mitochondria-targeted Radiocomplexes for CancerTheranostics". Paper presented in in TERACHEM 2022: Fourth InternationalSymposium on Technetium and Other Radiometals in Chemistry andMedicine, 2022.
  11. Santos, Joana F.; Maria Teresa Braz; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Frederik Cleeren; Mendes, Filipa; Fernandes, Célia; Paulo, António. Corresponding author: Santos, Joana F.. "Mitotropic Radiocomplexes for Auger Therapy of Prostate Cancer". Paper presented in 2nd Chem & BioChem Students Meeting, 2022.
  12. Santos, Joana F.; Silva, Francisco; Sousa, Andreia; Silva, Rafaela; Belo, Maria; Matos, António; Teresa Pinheiro; Marques, Fernanda; Fernandes, Célia. Corresponding author: Santos, Joana F.. "Selective gold (III) bisdithiolate-loadedmicelles to folate receptors in ovarian cancer theranostics". Paper presented in inII ASPIC-ASEICA International Meeting - Current Trends in Precision Medicinein Cancer, 2021.
  13. Fernandes, Célia; Paula Raposinho; Ana Belchior; Palma, Elisa; Francisco Silva; Guerreiro, Joana F.; Filipa, Mendes; António Paulo. "Organelle-Targeted Radioconjugates for Cancer Theranostics". Paper presented in First Workshop of the Laboratory for Physics of Materials and Emerging Technologies (LaPMET ), 2021.
Journal article
  1. Saray Argibay-Otero; Ara Núñez; Luis Muñoz; Rosa Carballo; Célia Fernandes; António Paulo; Ezequiel M. Vázquez-López. "Study of Mixed Re(I)/99mTc(I) Thiosemicarbazonate Complexes: Estrogen Receptor Affinity and Stability in Biological Media". European Journal of Inorganic Chemistry (2024): https://doi.org/10.1002/ejic.202400131.
    10.1002/ejic.202400131
  2. Palma, Elisa; Içhedef, Cigdem; Fernandes, Célia; Belchior, Ana; Raposinho, Paula; Gano, Lurdes; Miranda, André; et al. "Front Cover: Targeting of G-quadruplex DNA with 99mTc(I)/Re(I) Tricarbonyl Complexes Carrying Pyridostatin Derivatives (Chem. Eur. J. 22/2024)". Chemistry – A European Journal 30 22 (2024): http://dx.doi.org/10.1002/chem.202401135.
    10.1002/chem.202401135
  3. Elisa Palma; Cigdem Içhedef; Célia Fernandes; Ana Belchior; Paula Raposinho; Lurdes Gano; André Miranda; et al. "Targeting of G–quadruplex DNA with 99mTc(I)/Re(I) Tricarbonyl Complexes Carrying Pyridostatin Derivatives". Chemistry – A European Journal (2024): http://dx.doi.org/10.1002/chem.202400285.
    10.1002/chem.202400285
  4. Palma, Elisa; Santos, Joana F.; Fernandes, Célia; Paulo, António. "DNA-Targeted Complexes of Tc and Re for Biomedical Applications". Chemistry ¿ A European Journal (2024): http://dx.doi.org/10.1002/chem.202303591.
    Published • 10.1002/chem.202303591
  5. Santos, Joana F.; Braz, Maria T.; Raposinho, Paula; Cleeren, Frederik; Cassells, Irwin; Leekens, Simon; Cawthorne, Christopher; et al. Corresponding author: Paulo, António. "Synthesis and Preclinical Evaluation of PSMA-Targeted 111In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier". Molecular Pharmaceutics 21 1 (2023): 216-233. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00787.
    Published • 10.1021/acs.molpharmaceut.3c00787
  6. André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Leonardo, Ana; Nogueira, Sara; Amaral, Joana D.; Fernandes, Célia; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science 10 (2023): http://dx.doi.org/10.3389/fvets.2023.1236136.
    10.3389/fvets.2023.1236136
  7. Joana F. Santos; Raquel Azevedo; Miguel Prudêncio; Fernanda Marques; Yann Le Gal; Dominique Lorcy; Célia Fernandes. "Block Copolymer Micelles Encapsulating Au(III) Bis(Dithiolene) Complexes as Promising Nanostructures with Antiplasmodial Activity". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15031030.
    10.3390/pharmaceutics15031030
  8. Andreia Sousa; Joana F. Santos; Francisco Silva; Sousa SA; Jorge H. Leitão; António P. Matos; Teresa Pinheiro; et al. "Antitumoral and Antimicrobial Activities of Block Copolymer Micelles Containing Gold Bisdithiolate Complexes". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/2/564.
    10.3390/pharmaceutics15020564
  9. Jacinta O. Pinho; Mariana Matias; Vanda Marques; Carla Eleutério; Célia Fernandes; Lurdes Gano; Joana D. Amaral; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy (2023): https://doi.org/10.1016/j.biopha.2022.114021.
    10.1016/j.biopha.2022.114021
  10. Battistin, Federica; Fernandes, Célia; Raposinho, Paula. D.; Blacque, Olivier; Paulo, António; Alberto, Roger. "In vivo and in vitro studies of [M(¿6-pseudoerlotinib)2]+ sandwich complexes (M = Re, 99mTc)". Dalton Transactions 52 43 (2023): 15757-15766. http://dx.doi.org/10.1039/d3dt03011c.
    10.1039/d3dt03011c
  11. Alice D’Onofrio; Francisco Silva; Lurdes Gano; Paula Raposinho; Célia Fernandes; Arkadiusz Sikora; Monika Wyczólkowska; et al. "Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14122569.
    10.3390/pharmaceutics14122569
  12. Célia Fernandes; Joana Santos; Maria Braz; Francisco Silva; Paula Raposinho; Joana Guerreiro; Frederik Cleeren; et al. "Mitochondria-targeted radiocomplexes for cancer theranostics". Nuclear Medicine and Biology 114-115 (2022): S51-S52. http://dx.doi.org/10.1016/s0969-8051(22)02194-1.
    10.1016/s0969-8051(22)02194-1
  13. Célia Fernandes; Elisa Palma; Francisco Silva; Ana Belchior; Catarina I. G. Pinto; Joana F. Guerreiro; Hugo M. Botelho; et al. "Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus". International Journal of Molecular Sciences 23 13 (2022): 7238-7238. https://doi.org/10.3390/ijms23137238.
    10.3390/ijms23137238
  14. Diogo Figueiredo; Célia Fernandes; Francisco Silva; Elisa Palma; Paula Raposinho; Ana Belchior; Pedro Vaz; António Paulo. "Synthesis and Biological Evaluation of 99mTc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria". Molecules 26 2 (2021): 441-441. https://doi.org/10.3390/molecules26020441.
    10.3390/molecules26020441
  15. Elisabete Ribeiro; Fernanda Marques; Lurdes Gano; João D.G. Correia; Isabel Santos; Célia Fernandes. "Docetaxel-loaded block copolymer micelles labeled with 188Re for combined radiochemotherapy". Journal of Drug Delivery Science and Technology 60 (2020): 101898-101898. https://doi.org/10.1016/j.jddst.2020.101898.
    10.1016/j.jddst.2020.101898
  16. Belchior A; Di Maria S; Fernandes C; Vaz P; Paulo A; Raposinho P. "Radiobiological and dosimetric assessment of DNA-intercalated 99mTc-complexes bearing acridine orange derivatives.". EJNMMI research (2020): http://europepmc.org/abstract/med/32661612.
    10.1186/s13550-020-00663-9
  17. Argibay-Otero, S.; Gano, L.; Fernandes, C.; Paulo, A.; Carballo, R.; Vázquez-López, E.M.. "Chemical and biological studies of Re(I)/Tc(I) thiosemicarbazonate complexes relevant for the design of radiopharmaceuticals". Journal of Inorganic Biochemistry 203 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075265595&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2019.110917
  18. Fernandes, Célia. "Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance". Cancer Drug Resistance (2020): http://dx.doi.org/10.20517/cdr.2019.86.
  19. Mendes, F.; Gano, L.; Grilo, J.; Cunha, S.; Fernandes, C.; Paulo, A.. "Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance". Cancer Drug Resistance 3 2 (2020): 209-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-85101853113&partnerID=MN8TOARS.
    10.20517/cdr.2019.86
  20. Alvarez-Valdes, A.; Matesanz, A.I.; Perles, J.; Fernandes, C.; Correia, J.D.G.; Mendes, F.; Quiroga, A.G.. "Novel structures of platinum complexes bearing N-bisphosphonates and study of their biological properties". Journal of Inorganic Biochemistry 191 (2019): 112-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057163055&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2018.11.010
  21. Pino-Cuevas, A.; Raposinho, P.D.; Fernandes, C.; Paulo, A.; Abram, U.; Carballo, R.; Vázquez-López, E.M.. "Thiosemicarbazonate complexes with affinity for amyloid-ß fibers: Synthesis, characterization and biological studies". Future Medicinal Chemistry 11 19 (2019): 2527-2546. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073597851&partnerID=MN8TOARS.
    10.4155/fmc-2019-0013
  22. Fernandes, Célia. "A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells.". ChemMedChem (2017): http://europepmc.org/abstract/med/28628723.
    10.1002/cmdc.201700287
  23. Neves V; Aires-da-Silva F; Morais M; Gano L; Ribeiro E; Pinto A; Aguiar S; et al. "Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood-Brain Barrier through a Receptor-Free Mechanism.". (2017): http://europepmc.org/abstract/med/28263555.
    10.1021/acschembio.7b00087
  24. Mihalik, J.; Corisco, J.A.; Fernandes, C.; Ribeiro, E.; Madruga, M.J.. "Release of137Cs from plant mass in course of biodegradation". Journal of Radioanalytical and Nuclear Chemistry 314 2 (2017): 1453-1461. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031422742&partnerID=MN8TOARS.
    10.1007/s10967-017-5509-2
  25. Silva, F.; Fernandes, C.; Campello, M. P. C.; Paulo, A.. "Metal complexes of tridentate tripod ligands in medical imaging and therapy". Polyhedron 125 (2017): 186-205. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397834400027&KeyUID=WOS:000397834400027.
    10.1016/j.poly.2016.11.040
  26. Neves, Vera; Silva, Frederico Aires da; Morais, Maurício; Gano, Lurdes; Ribeiro, Elisabete; Pinto, Antónia; Aguiar, Sandra; et al. "Novel peptides derived from dengue virus capsid protein translocate reversibly the blood-brain barrier through a receptor-free mechanism". (2017): http://hdl.handle.net/10451/32811.
    10.1021/acschembio.7b00087
  27. Mihalik, Jan; Corisco, José; Fernandes, Célia; Ribeiro, E.; Madruga, Maria José. "Release of 137Cs from plant mass in course of biodegradation". J Radioanal Nucl Chem (2017):
    https://doi.org/10.1007/s10967-017-5509-2
  28. Ribeiro E; Alho I; Marques F; Gano L; Correia I; Correia JD; Casimiro S; et al. "Radiolabeled block copolymer micelles for image-guided drug delivery.". (2016): http://europepmc.org/abstract/med/27825862.
    10.1016/j.ijpharm.2016.11.004
  29. Imstepf S; Pierroz V; Raposinho P; Felber M; Fox T; Fernandes C; Gasser G; Santos IR; Alberto R. "Towards (99m)Tc-based imaging agents with effective doxorubicin mimetics: a molecular and cellular study.". (2016): http://europepmc.org/abstract/med/27097328.
    10.1039/c6dt00871b
  30. Bihari Z; Vultos F; Fernandes C; Gano L; Santos I; Correia JD; Buglyó P. "Synthesis, characterization and biological evaluation of a (67)Ga-labeled (¿(6)-Tyr)Ru(¿(5)-Cp) peptide complex with the HAV motif.". (2016): http://europepmc.org/abstract/med/26907798.
    10.1016/j.jinorgbio.2016.02.011
  31. Fernandes C; Monteiro S; Belchior A; Marques F; Gano L; Correia JD; Santos I. "Novel (188)Re multi-functional bone-seeking compounds: Synthesis, biological and radiotoxic effects in metastatic breast cancer cells.". (2016): http://europepmc.org/abstract/med/26872439.
    10.1016/j.nucmedbio.2015.11.004
  32. Imstepf S; Pierroz V; Raposinho P; Bauwens M; Felber M; Fox T; Shapiro AB; et al. "Nuclear Targeting with an Auger Electron Emitter Potentiates the Action of a Widely Used Antineoplastic Drug.". (2015): http://europepmc.org/abstract/med/26473388.
    10.1021/acs.bioconjchem.5b00466
  33. Vultos, Filipe; Cunha, Susana; Fernandes, Celia; Oliveira, Maria Cristina; Marques, Fernanda; Botelho, Maria Filomena; Santos, Isabel; Gano, Lurdes. "New estradiol based In-111 complex towards the estrogen receptor". Radiochimica Acta 103 11 (2015): 765-776. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363907500003&KeyUID=WOS:000363907500003.
    10.1515/ract-2014-2355
  34. Silva, Francisco; Campello, Maria Paula C.; Gano, Lurdes; Fernandes, Celia; Santos, Isabel C.; Santos, Isabel; Ascenso, Jose R.; Joao Ferreira, M.; Paulo, Antonio. "Chemical, radiochemical and biological studies of new gallium(III) complexes with hexadentate chelators". Dalton Transactions 44 7 (2015): 3342-3355. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349403100047&KeyUID=WOS:000349403100047.
    10.1039/c4dt02274b
  35. Adriaenssens L; Liu Q; Chaux-Picquet F; Tasan S; Picquet M; Denat F; Le Gendre P; et al. "Novel heterobimetallic radiotheranostic: preparation, activity, and biodistribution.". (2014): http://europepmc.org/abstract/med/24449620.
    10.1002/cmdc.201300494
  36. Vultos, F.; Fernandes, C.; Correia, J. D. G.; Santos, I.; Gano, L.. "In-111 labeled peptides targeting the estrogen receptor for theranostic of cancer". Nuclear Medicine and Biology 41 7 (2014): 645-645. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339599500126&KeyUID=WOS:000339599500126.
    10.1016/j.nucmedbio.2014.05.044
  37. Fernandes, C.; Monteiro, S.; Mendes, P.; Gano, L.; Marques, F.; Casimiro, S.; Costa, L.; Correia, J.D.G.; Santos, I.. "Biological assessment of novel bisphosphonate-containing 99mTc/Re-organometallic complexes". Journal of Organometallic Chemistry (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886959842&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2013.10.038
  38. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Perfusion and specific radioprobes for cardiac imaging". CARDIOTECHNIX 2013 - Proceedings of the International Congress on Cardiovascular Technologies (2013): 79-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887219380&partnerID=MN8TOARS.
  39. Fernandes, C.; Maria, L.; Gano, L.; Santos, I.C.; Santos, I.; Paulo, A.. "Re(I) and 99mTc(I) tricarbonyl complexes with ether-containing pyrazolyl-based chelators: Chemistry, biodistribution and metabolism". Journal of Organometallic Chemistry (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84889054930&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2013.11.013
  40. Can, Daniel; Spingler, Bernhard; Schmutz, Paul; Mendes, Filipa; Raposinho, Paula; Fernandes, Célia; Carta, Fabrizio; et al. "[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX". Angewandte Chemie 124 14 (2012): 3410-3413. http://dx.doi.org/10.1002/ange.201107333.
    10.1002/ange.201107333
  41. Neto, C.; Fernandes, C.; Oliveira, M.C.; Gano, L.; Mendes, F.; Kniess, T.; Santos, I.. "Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents". Nuclear Medicine and Biology 39 2 (2012): 247-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856346831&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2011.09.001
  42. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent". Nuclear Medicine and Biology 39 2 (2012): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856362049&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2011.08.007
  43. Can, D.; Spingler, B.; Schmutz, P.; Mendes, F.; Raposinho, P.; Fernandes, C.; Carta, F.; et al. "(M=Re or 99mTc) arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX". Angewandte Chemie - International Edition 51 14 (2012): 3354-3357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859226949&partnerID=MN8TOARS.
    10.1002/anie.201107333
  44. Cunha, S.; Vultos, F.; Fernandes, C.; Oliveira, M. C.; Botelho, M. F.; Santos, I.; Gano, L.. "Novel In-111-estradiol based complexes: preclinical evaluation for oestrogen positive tumour targeting". European Journal of Nuclear Medicine and Molecular Imaging 39 (2012): S530-S530. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000309726603129&KeyUID=WOS:000309726603129.
  45. Neto, Carina; Fernandes, Celia; Oliveira, Cristina; Gano, Lurdes; Mendes, Filipa; Kniess, Torsten; Santos, Isabel. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". Journal of Labelled Compounds & Radiopharmaceuticals 54 (2011): S171-S171. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000295901600171&KeyUID=WOS:000295901600171.
  46. Goethals, L.R.; Santos, I.; Caveliers, V.; Paulo, A.; De Geeter, F.; Lurdes, P.G.; Fernandes, C.; Lahoutte, T.. "Rapid hepatic clearance of 99mTc-TMEOP: A new candidate for myocardial perfusion imaging". Contrast Media and Molecular Imaging 6 4 (2011): 178-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051945093&partnerID=MN8TOARS.
    10.1002/cmmi.413
  47. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Evaluation of (99)mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance". European Journal of Nuclear Medicine and Molecular Imaging 37 (2010): S358-S358. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000283023801128&KeyUID=WOS:000283023801128.
  48. Peindy N'Dongo, H.W.; Raposinho, P.D.; Fernandes, C.; Santos, I.; Can, D.; Schmutz, P.; Spingler, B.; Alberto, R.. "Preparation and biological evaluation of cyclopentadienyl-based 99mTc-complexes [(Cp-R)99mTc(CO)3] mimicking benzamides for malignant melanoma targeting". Nuclear Medicine and Biology 37 3 (2010): 255-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950298117&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2009.11.006
  49. Suzuki, Katia N.; Gano, Lurdes; Fernandes, Celia; Paulo, Antonio; Santos, Isabel. "Tc-99m(I) cationic complexes for tumoral detection". Nuclear Medicine and Biology 37 6 (2010): 709-710. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000281075100125&KeyUID=WOS:000281075100125.
    10.1016/j.nucmedbio.2010.04.103
  50. Santos, I.; Maria, L.; Fernandes, C.; Garcia, R.; Gano, L.; Paulo, A.; Santos, I.C.. "Tris(pyrazolyl)methane 99mTc tricarbonyl complexes for myocardial imaging". Dalton Transactions 4 (2009): 603-606. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149513007&partnerID=MN8TOARS.
    10.1039/b817451b
  51. Moura, C.; Fernandes, C.; Gano, L.; Paulo, A.; Santos, I.C.; Santos, I.; Calhorda, M.J.. "Influence of the ligand donor atoms on the in vitro stability of rhenium(I) and technetium (I)-99m complexes with pyrazole-containing chelators: Experimental and DFT studies". Journal of Organometallic Chemistry 694 6 (2009): 950-958. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749132724&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2008.11.027
  52. Fernandes, C.; Santos, I.C.; Santos, I.; Pietzsch, H.-J.; Kunstler, J.-U.; Kraus, W.; Rey, A.; et al. "Rhenium and technetium complexes bearing quinazoline derivatives: Progress towards a 99mTc biomarker for EGFR-TK imaging". Dalton Transactions 24 (2008): 3215-3225. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949214678&partnerID=MN8TOARS.
    10.1039/b802021c
  53. Fernandes, C.; Oliveira, C.; Gano, L.; Bourkoula, A.; Pirmettis, I.; Santos, I.. "Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer". Bioorganic and Medicinal Chemistry 15 12 (2007): 3974-3980. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247846160&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.04.008
  54. Fernandes, C.; Correia, J.D.G.; Gano, L.; Santos, I.; Seifert, S.; Syhre, R.; Bergmann, R.; Spies, H.. "Dramatic effect of the tridentate ligand on the stability of 99mTc "3 + 1" oxo complexes bearing arylpiperazine derivatives". Bioconjugate Chemistry 16 3 (2005): 660-668. http://www.scopus.com/inward/record.url?eid=2-s2.0-18844423026&partnerID=MN8TOARS.
    10.1021/bc049718k
  55. Fernandes, C.; Kniess, T.; Gano, L.; Seifert, S.; Spies, H.; Santos, I.. "Synthesis and biological evaluation of silylated mixed-ligand 99mTc complexes with the [PNS/S] donor atom set". Nuclear Medicine and Biology 31 6 (2004): 785-793. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042836911&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2004.03.011
  56. Fernandes, C.; Patrício, L.; Moreira, R.; Cantinho, G.; Pena, H.; Campello, P.C.; Santos, I.. "Novel 3+1 mixed-ligand Technetium-99m complexes carrying dipeptides as monodentate ligands". Nuclear Medicine and Biology 31 1 (2004): 139-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642492860&partnerID=MN8TOARS.
    10.1016/S0969-8051(03)00129-X
  57. Kniess, T.; Fernandes, C.; Santos, I.; Kraus, W.; Spies, H.. "Silylated mixed-ligand rhenium complexes with the [PNS/S] donor atom set". Inorganica Chimica Acta 348 (2003): 237-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038394582&partnerID=MN8TOARS.
    10.1016/S0020-1693(02)01486-X
  58. Fernandes, C.; Correia, J. D. G.; Gano, L.; Santos, I.; Seifert, S.; Syhre, R.; Spies, H.. "Tc Oxocomplexes with the PNO/S and PNS/S donor atom sets: Labelling of a 5HT1A receptor - binding ligand". Journal of Labelled Compounds and Radiopharmaceuticals 44 S1 (2001): S518-S520. http://dx.doi.org/10.1002/jlcr.25804401184.
    10.1002/jlcr.25804401184
  59. Fernandes, Célia; Rui Moreira; R. Dias; H. Pena; G. Cantinho; L. Patricio. "Péptidos-99mTc: Marcação e Biodistribuição em Murganhos". Revista Española de Medicina Nuclear 17 (1998): 399-399.
    Published
  60. Gano, L.; Fernandes, C.; Cantinho, G.; Santos, A.I.; Pena, H.; Vieira, R.; Salgado, L.; Patrício, L.. "Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: Evaluation of different methods | 99mTc-markierung des monoklonalen antikorpers IOR CEA 1: Bewertung unterschiedlicher methoden". NuklearMedizin 36 6 (1997): 205-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030612103&partnerID=MN8TOARS.
  61. Gano, L; Fernandes, C; Cantinho, G; Santos, AI; Pena, H; Vieira, R; Salgado, L; Patricio, L. "Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: Evaluation of different methods". Nuklearmedizin 36 6 (1997): 205-212. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997XX91500005&KeyUID=WOS:A1997XX91500005.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/10 Avaliação pré-clínica de complexos de 111In e 161Tb para radioteranóstica do cancro da próstata 11as Jornadas de Medicina Nuclear do Hospital Garcia de Orta
Medicina Nuclear, Hospital Garcia da Orta (Costa da Caparica, Portugal)
2023/10 Dual-targeted 111In- and 161Tb-Radiocomplexes for Prostate Cancer Theranostics Optimizing Imaging and Dose-Response in RadiotherapieS Workshop
(Erqui, France)
2023/09 Radiobiological and preclinical imaging studies of PSMA-targeted radioconjugates containing a mitochondria-tropic carrier 10th International Symposium on the Physical, Molecular and Medical Aspects of Auger Electron Processes
(Montpellier, France)
2023/06/02 THER-PBCT – Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer Online Advanced Course on Biomedical Imaging 2023; Session on Proton Therapy
UT MD Anderson Cancer Center, German Cancer Research Center and UT Austin Portugal Projects
2022/09/24 Radiocomplexos dirigidos a organelos celulares para terapia Auger do cancro 4º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO)
Núcleo Regional do Norte da Liga Portuguesa Contra o Cancro (Porto, Portugal)
2022/09/06 Novel Radioconjugates for Auger Electron Therapy of Prostate Cancer NInTec Science Days
IST (Lisboa, Portugal)
2022/07/20 Mitochondria-targeted Radiocomplexes for Auger Electron Therapy of Cancer 16th European Biological Inorganic Chemistry Conference (EuroBIC-16)
(Grenoble, France)
2020/12 Research on SPECT Radiopharmaceuticals On-line Course in “Radiopharmacy”,
Associação Portuguesa dos Técnicos de Radiologia, Radioterapia e Medicina Nuclear (ATARP) (Portugal)
2019/09/04 Radiobiological and Dosimetric Assessment of DNA-Targeted 99mTc(I) Complexes NOVA BIOPHYSICA International Congress
(Portugal)
2019/07/08 Molecular and Nanosized Radioconjugates for Cancer Theranostics Encontro com a Ciência e Tecnologia em Portugal
(Lisboa, Portugal)
2019/05/27 Assessment of the Energy Deposited and Biological Damage Induced by DNA-targeted 99mTc-complexes 3rd International Conference on Dosimetry and its Applications
(Lisboa, Portugal)
2019/04/06 Desenvolvimento de novos radiofármacos 1as Jornadas de Imagem Médica e Radioterapia
Escola Superior de Saúde da Cruz Vermelha Portuguesa (Lisboa, Portugal)
2018/04/18 Biological Assessment of a Radiolabelled LXXLL-Peptide for Breast Cancer Theranostics 19th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Groningen, Netherlands)
2018/03 Multifunctional agent for breast cancer radiotheranostics Fourth International Conference on Precision Image-Guided Small Animal Radiotherapy Research
(Lisboa, Portugal)
2016/02 A novel peptide platform derived from Dengue virus for drug delivery into the brain XV EPI: 15th Iberian Peptide Meeting
(porto, Portugal)
2016/02 In-111 labeled peptides towards the estrogen receptor for theranostic of breast cancer XV EPI: 15th Iberian Peptide Meeting
Universidade do Porto Faculdade de Ciências (Porto, Portugal)
2016/02 Novel radiopeptides for molecular imaging of EGFR positive tumors XV EPI: 15th Iberian Peptide Meeting
Universidade do Porto Faculdade de Ciências (Porto, Portugal)
2015/09/07 Bisphosphonate-containing 99mTc(I)/188Re(I) organometallic complexes for theranostic applications COST TD1004, Annual Meeting
(Belgrade, Serbia)
2015/04/15 Radiotoxic and genotoxic effects of 188Re multi-functional bone-seeking agents Workshop LOWDOSE-PT-2015 - "Biological effects and risks of low dose and protracted exposures to ionizing radiation
Sociedade Portuguesa de Proteção Contra Radiações (Lisboa, Portugal)
2015/04 Influence of the radionuclide on the stability and biological profile of a ER targeting peptide Workshop LOWDOSE-PT- 2015/Biological effects and risks of low dose and protracted exposures to ionizing radiation
Sociedade Portuguesa de Proteção Contra Radiações (Bobadela-Loures, Portugal)
2014/12 Block copolymer micelles for cancer therapy XVIII Congress of Portuguese Biochemical Society
Portuguese Biochemical Society (Coimbra, Portugal)
2014/05 Methods of analytical control and purification COST Training School: "Peptides for Targeted Drug Delivery - Hands-on"
COST Action CM1105“Functional metal complexes that bind to biomolecules” (Loures, Portugal)
2014/04 Novel 111In-estradiol based complexes for oestrogen receptor targeting 17th European Symposium on Radiopharmacy and Radiopharmaceuticals (ESRR’14)
eanm (Pamplona, Spain)
2013/12 Complexos de 111In derivados de estradiol: avaliação pré- clínica para o diagnóstico do cancro da mama XIV Congresso Nacional Medicina Nuclear
Sociedade Portuguesa de Medicina Nuclear (Porto, Portugal)
2013/12 Avaliação biológica de novos complexos de 99mTc(I) no diagnóstico de metástases ósseas XIV Congresso Nacional Medicina Nuclear
Sociedade Portuguesa de Medicina Nuclear (Porto, Portugal)
2013/10 Evaluation of protein-losing gastroenteropathy in pediatrics with 99mTc-Human Serum Albumin - technical and methodological developments Annual Congress of the European-Association-of-Nuclear-Medicine (EANM)
European Association of Nuclear Medicine (Lyon, France)
2013/10 Indium-111 radiolabelled peptide for theranostics of ER positive tumours NanoFar Autumn School 2013
University of Santiago de Compostela (Santiago de Compostela, Spain)
2013/09 Indium-111 radiolabelled peptide towards the estrogen receptor The Future of radiation oncology: Imaging, Dosimetry, Biology & Therapy - Seventh Berder Workshop
(France)
2013/09 Perfusion and specific radioprobes for cardiac imaging 1st International Congress on Cardiovascular Technologies – CARDIOTECHNIX 2013
(Vilamoura, Portugal)
2010/04 Biological evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection European Symposium on Radiopharmacy and Radiopharmaceuticals - ESRR 2010
EANM (Edinburgh, United Kingdom)
2007/11 Novel Biomarkers for Molecular Imaging of EGFR positive tumors. XI Congresso Medicina Nuclear
SPMN (Porto, Portugal)
2005/09/30 Biocomplexos de 99mTc para Imagiologia Molecular de Receptores 5-HT1A e EGFR
Faculdade de Farmácia, Universidade de Lisboa (Lisboa, Portugal)
2004/09 99mTc Mixed-ligand complexes with heterofunctionalized phosphines with high affinity for 5-HT1A receptor 12th European Symposium on Radiopharmacy and Radiopharmaceuticals,
(Sopot)
2004/05 Technetium-99m Mixed-Ligand Complexes with Heterofunctionalized Phosphines for Labelling CNS- Receptor Ligands COST Action B12: Radiotracers for in vivo assessment of biological function
(Sacavém, Portugal)
2002/11 Organosilicon bearing Re/Tc complexes: Aim and Status COST Action B12: Radiotracers for in vivo assessment of biological function
(Sacavém)
2001/11 Visualização de receptores dopaminérgicos utilizando radiofármacos marcados com halogéneos e 99mTc Curso de Produção e Utilização Médica de Radiofármacos
(Coimbra, Portugal)
1996/06 Technetium-99m labelling of the IORCEA1 Monoclonal antibody: Evaluation of different methods IAEA Research Coordination Meeting
IAEA (Atenas, Greece)
1995 Influência do Método de marcação na Imunoreactividade de IOR CEA 1-99mTc IV Curso de Divulgação de Medicina Nuclear: "Medicina Nuclear e Oncologia"
(Lisboa, Portugal)
1994/10 Radiolabelling of Antibodies with 99mTc Comparison of Different Methods IAEA Research Co-ordination Meeting
(Sydney, Australia)
1994 Influência da Permeabilidade Vascular na Detecção de Processos Inflamatórios com HIG-99mTc V Congresso Nacional Medicina Nuclear
(Porto)
1994 Marcação e Controlo de Qualidade de Anticorpos Monoclonais V congresso Medicina Nuclear
Sociedade Portuguesa de Medicina Nuclear (Porto)
1993/03 Determination of Tin in 99mTc-Radiopharmaceuticals 5th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Cambridge, United Kingdom)
1989/05 Radiofármacos Renais - sua ligação às proteínas plasmáticas Curso de Medicina Nuclear
(Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/11/01 - Current EGFR/SHP2-targeted nanomedicines for colorectal cancer theranostic
Supervisor of Joana Filipa da Silva Santos
 Biotecnologia e Biociências (PhD)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2023/09/01 - Current Subcellular Targeted Radiopharmaceuticals to Unravel the Potential of Auger-Electron Cancer Therapy
Co-supervisor of Catarina Dorisa Azevedo da Silva
 Engenharia Biomédica (PhD)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2024/02 - 2024/12 T-MoMa: Therapeutic Molecular Materials
Co-supervisor
 Engenharia Química (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/02 - 2024/12 Avaliação pré-clínica de novas nanoplataformas para terapia de melanoma
Supervisor of Carolina Sequeira Azenha
 Engenharia Biológica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/01/30 - 2024/10 Dual-Imaging Radiocomplexes for Prostate Cancer
Supervisor of Maria Trindade Santos
 Ciências de Engenharia Química e Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/10 - 2024/01 Dual-Imaging Radiocomplexes for Prostate Cancer
Supervisor of Matilde Correia Aragão
Engenharia Biológica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/10 - 2024/01 Dual-Imaging Radiocomplexes for Prostate Cancer
Supervisor of Beatriz Moniz Branco
 Engenharia Biológica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/10 - 2024/01 Radiocomplexes for Prostate Cancer Theranostics
Supervisor of • Miguel Militão Baptista
 Engenharia Biomédica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/20 - 2023/07 Dual Targeted Radiocomplexes for Cancer Theranostics; Projecto Integrador de 1º Ciclo em Engenharia Biológica
Supervisor of André Redondo
 Engenharia Biológica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/20 - 2023/07 Dual Targeted Radiocomplexes for Cancer Theranostics; Integrated 1st Cycle (BSc) Project in Biomedical Engineering,
Supervisor of Catarina Baptista
 Engenharia Biomédica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/20 - 2023/07 Mitochondria Targeted Radiocomplexes for Prostate Cancer Theranostics; 1st Cycle (BSc) Project in Biomedical Engineering
Supervisor of Inês Pereira Cardoso
 Engenharia Biomédica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/20 - 2023/07 Aminoácidos radio-marcados para o diagnóstico de cancro
Supervisor of Rodrigo Sancho Ramos Borges da Costa
 Engenharia Biomédica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/01 - 2023/07 Nanoparticle Radiolabelling with 99mTc for Cancer Theranostics
Supervisor of Maria Teixeira Rebouta
 Engenharia Biomédica e Biofísica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/03/01 - 2022/07 Dual-targeted Complexes for Prostate Cancer Theranostics
Supervisor of César Mateus Caires Batista Rosa
 Engenharia Biomédica (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/03/01 - 2021/12/10 Dual-Targeted Radiocomplexes for Prostate Cancer Theranostics
Supervisor of Ana Rita Mosquito Julião
 Integrated Master in Chemical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/03/01 - 2021/12 Mitochondria-Targeted 111In-Radiocomplexes for Auger Therapy of Prostate Cancer
Supervisor of Maria Teresa de Noronha Walenta Braz
 Bioengenharia e Nanossistemas (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02 - 2021/11 Block copolymer micelles for targeted delivery of anticancer drugs and radioisotopes
Supervisor of Joana Filipa da Silva Santos
 Engenharia Química (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2021/11 Block copolymer micelles for targeted delivery of anticancer drugs and radioisotopes
Supervisor of Joana Filipa Da Silva Santos
 Engenharia Química (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/03/01 - 2021/01/26 Block Copolymer Micelles for Drug Delivery
Supervisor of Andreia Filipa Fidalgo de Sousa
 Integrated Master in Chemical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/02 - 2018/07 Terapia com Eletrões Auger - Alaranjado de Acridina como molécula intercaladora do DNA
Supervisor
 Undergraduate research project in Nuclear Medicine (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2013/07 - 2018/05/29 111In-labelled Peptides for Breast Cancer Theranostics
Co-supervisor of Filipe André Jardim dos Vultos
 Chemistry (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/04/02 - 2018/04/27 CLICKABLE RADIOCOMPLEXES FOR IN VIVO CHEMISTRY WITHIN PRE-TARGETING APPROACHES
Co-supervisor of Andreia Filipa Almeida
 Medicinal Chemistry PhD Programme (MedChemTrain) - Laboratorial Rotations (Other)
2018/03/01 - 2018/03/26 Clickable Radiocomplexes for In Vivo Chemistry within Pre-targeting Approaches
Co-supervisor of Cátia Marques
 Medicinal Chemistry PhD Programme (MedChemTrain) - Laboratorial Rotations (Other)
Centro de Ciências e Tecnologias Nucleares, Portugal
2017/10 - 2017/12 Síntese de complexos de 99mTc(I) com afinidade para as placas ß amiloide
Supervisor
 Undergraduate research project in Nuclear Medicine (Scientific initiation)
2016/10 - 2017/01 Marcação de um kit de Nanocoll com 68Ga
Supervisor
 Undergraduate research project in Nuclear Medicine (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2016/02 - 2016/06 Sondas radioativas de 67Ga e 64Cu dirigidas aos recetores do fator de crescimento epidérmico
Supervisor
 Undergraduate research project in Nuclear Medicine (Scientific initiation)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2016/04/01 - 2016/04/30 Block Copolymer Micelles as multifunctional nanoplatforms for Drug Delivery
Supervisor
 Medicinal Chemistry PhD Programme (MedChemTrain)- Laboratorial Rotations (Other)
2013/06 - 2016/02 Molecular and nano tools for cancer theranostics - Project EXCL/QEQ-MED/0233/2012
Supervisor
2012 - 2014/06/11 Análogos do neuropéptido Y marcados com 67Ga para imagiologia molecular dos recetores Y1 no cancro de mama
Supervisor
 Tese de mestrado em Química Inorgânica Biomédica, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2014 (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/06 - 2014/02 Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents (PTDC/QUI-QUI/115712/2009)
Supervisor of Sofia Monteiro
2011/06 - 2013/06 Synthesis and Pre-clinical Evaluation of Novel Estradiol-Based Indium Complexes for Targeted Radiotherapy of Tumors - (PTDC/QUI-QUI/111891/2009).
Co-supervisor of Filipe André Jardim dos Vultos
2011 - 2012/11/23 Síntese, Caracterização e Avaliação Biológica de Compostos Multifuncionais Ostreotópicos
Supervisor
 Tese de mestrado em Química Inorgânica Biomédica (Aplicações em Diagnóstico e Terapia), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012 (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 ASSESSMENT OF MERCURY-SELENIUM INTERACTION IN FISH AND ASSOCIATED HUMAN DIETARY EXPOSURE
(Thesis) Arguer
 Mariana Raposo Guerra Mendes Ribeiro (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2024 Iodo na Alimentação: Estudo em Portugal e com Incidência em Ambiente Escolar
(Thesis) Arguer
 Inês Margarida Ferreira Delgado. (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/11/20 Novel peptides aimed at interacting with the intracellular domain of dopamine receptor type 2
(Thesis) Main arguer
 Inês Teodósio Vicente (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/11/24 Inhibition of protein-protein interactions in dopamine receptors with peptides towards pharmacological activity
(Thesis) Main arguer
 Francisco Marques Lucas (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/12/07 Dual-Targeted Radiocomplexes for Prostate Cancer Theranostics
Supervisor
 Ana Rita Mosquito Julião (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/12/06 Mitochondria-Targeted 111In-Radiocomplexes for Auger Therapy of Prostate Cancer
Supervisor
 Maria Teresa de Noronha Walenta Braz (Master)
2021/11/26 Design of novel peptides that interact with G-protein coupled receptors
(Thesis) Main arguer
 Cátia Filipa Gouveia Rosa (Master)
2021/01/26 Block Copolymer Micelles for Drug Delivery
Supervisor
 Andreia Filipa Fidalgo de Sousa (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/05/04 Clickable Radiocomplexes for In Vivo Chemistry within Pre-targeting Approaches
(Thesis) Main arguer
 Andreia Filipa Almeida (Other)
2018/03/29 Clickable Radiocomplexes for In Vivo Chemistry within Pre-targeting Approaches
(Thesis) Main arguer
 Cátia Marques (Other)
2016/04 Block Copolymer Micelles as multifunctional nanoplatforms for Drug Delivery
Supervisor
 Vanessa Tomé (Other)
2015/05 Avaliação do potencial clínico de novos ligandos para o receptor estrogénico em diagnóstico e terapia de tumores da mama
(Thesis) Arguer
 Susana Manuela Pereira da Cunha (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/03/26 Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents Evaluation of the effects of new compounds in breast and prostate cancer cell lines, cell outcome and assessment of the mechanisms of action
(Thesis) Main arguer
 Diana Domingos de Matos (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 Análogos do neuropéptido Y marcados com 67Ga para imagiologia molecular dos recetores Y1 no cancro de mama
Supervisor
 Isabel Sofia Caldeira Rodrigues (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/03 Fracionamento de kits de HMDP para marcação com 99mTc – Influência da temperatura e da idade das fracções
(Thesis) Main arguer
 Vanessa Santos (Master)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/12 Análogos do Neuropéptido Y marcados com 99mTc para detecção de receptores Y1 expressos no cancro da mama
(Thesis) Main arguer
 Marta Sofia de Oliveira Antunes (Master)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/11/23 Síntese, Caracterização e Avaliação Biológica de Compostos Multifuncionais Osteotrópicos
Supervisor
 Patrícia Raquel Henriques Serra Mendes (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 Sondas radioactivas dirigidas a receptores do factor de crescimento epidérmico e a receptores estrogénicos
(Thesis) Arguer
 Carina Sofia Rosa Neto (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2014/11 - Current ASPIC - Associação Portuguesa para Investigação em Cancro member
2014 - Current EACR
1987 - Current Sociedade Portuguesa de Medicina Nuclear member

Conference scientific committee

Conference name Conference host
2019/01 - 2019/11/30 XVII Congresso Nacional de Medicina Nuclear Instituto Português de Oncologia do Porto FG, EPE (IPO-Porto)

Consulting

Activity description Institution / Organization
2022/03/21 - Current IAEA Future Activities on Tc-99m Kits and Radiopharmaceuticals (EVT2104010) International Atomic Energy Agency, Austria

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/03 - Current Radiochemistry Radiochemistry Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2020/09/08 - 2020/09/10 1st C2TN Summer School – “CARISMA 2020” CARISMA (Ciências e Aplicações das Radiações Ionizante na Saúde, Materiais e Ambiente), C2TN's Summer School 1st C2TN Summer School – “CARISMA 2020” (Outros) Centro de Ciências e Tecnologias Nucleares, Portugal
2020/01/17 - 2020/01/30 Invited lecturer, "Development of new radiopharmaceuticals; Analytical control and purification of radiopharmaceuticals" 8h Radiações Aplicadas às Tecnologias da Saúde (Mestrado integrado) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Mentoring / Tutoring

Topic Student name
2022/03/01 - Current Dual-targeted Complexes for Prostate Cancer Theranostics César Rosa

Other jury / evaluation

Activity description Institution / Organization
2023/01 - 2023/01 Member of the THESIS ADVISORY COMMITTEE (CAT) of the PhD thesis from the Doctoral Program in Chemistry: Thesis title: Targeting Cationic Amino Acid Transporters with Radiometallated Amino Acids for Cancer Theranostics PhD Student: Rúben Silva Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/04/13 - 2021/04/13 President of the following Thesis Advisory Committee (CAT): Thesis title: ASSESSEMENT OF MERCURY-SELENIUM INTERACTION IN FISH AND ASSOCIATED HUMAN DIETARY EXPOSURE; PhD Student: Mariana Raposo Guerra Mendes Ribeiro Universidade de Lisboa Instituto Superior Técnico, Portugal

Scientific expedition

Activity description Institution / Organization
2023/05/04 - 2023/05/24 Short Term Scientific Mission to participate in the "Proton irradiation experiments with pancreatic cancer cell models" within the scope of the project, Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer¿ UTAP-EXPL/FMT/0020/2021) The University of Texas MD Anderson Cancer Center, United States
Distinctions

Award

2023 Best oral presentation at 11as Jornadas de Medicina Nuclear do Hospital Garcia de Orta, 10-11 Novembro, 2023, Costa da Caparica, Portugal
2002 Best Poster at 6th International Symposium on Technetium and other metals
1998 Prémio Nycomed Amersham - Best Poster - VII Congresso de Medicina Nuclear