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Currently Assistant Professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto and researcher at i3S, Instituto de Investigação e Inovação em Saúde (Biofabrication group). Graduated in Chemical Engineering, with a PhD in Biotechnology (Instituto Superior Técnico, Universidade de Lisboa), in collaboration with University of Nevada, Reno, USA,, on expansion of hematopoietic stem cells. After a short period in a business environment, I joined the Instituto de Engenharia Biomédica (INEB), Porto, where I broadened my knowledge on biomaterials, namely in surface modification at the molecular level. Later, I spent a received a prestigious Humboldt fellowship for Experiencied Researcher, spending a sabatic period in Ulm, Germany. In 2020, I co-found FETALDISC, an i3S spin-off company dedicated to fetal-based therapies for low back pain. My scientific interests focus on bioengineering in health, in particular regenerative engineering. In the last years, I have focused on the development of immunomodulatory therapies based on stem cells and biomaterials for intervertebral disc. The generated knowledge has been translated to other osteoarticular tissues and to immunotherapy-based therapies for cancer.
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Identification

Personal identification

Full name
Raquel Madeira Gonçalves

Citation names

  • Gonçalves, Raquel

Author identifiers

Ciência ID
3C10-8CAF-4CDD
ORCID iD
0000-0003-2841-0485
Researcher Id
C-5940-2012
Scopus Author Id
7101988905

Email addresses

  • raquelg@i3s.up.pt (Professional)
  • rmgoncalves@icbas.up.pt (Professional)

Telephones

Telephone
  • 220408800 (Professional)

Addresses

  • R. Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)
  • Rua de Jorge Viterbo Ferreira nº. 228, 4050-313, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Medical Engineering - Medical Engineering
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2021/12/20 - 2022/01/14
Attended
 Construção e análise da qualidade dos testes (Outros)
Universidade do Porto, Portugal
2021/10/25 - 2021/11/04
Concluded
 Introdução à prática pedagógica no Ensino Superior (Outros)
Universidade do Porto, Portugal
2021/05/05 - 2021/05/31
Attended
 Building and Leading Research Teams (Outros)
Universidade do Porto Faculdade de Psicologia e de Ciências da Educação, Portugal
2020/04 - 2020/06
Concluded
 BSL-2 training (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016
Concluded
 Pedagogic Workshop “To plan, to teach and to evaluate in Higher Education” (Outros)
Universidade do Porto, Portugal
2014
Concluded
 Pedagogic Program “De Par em Par”, Peer-to-Peer Evaluation (Outros)
Universidade do Porto, Portugal
2013
Concluded
 Animal Experimentation Training Course, FELASA C (40h) (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013
Concluded
 Animal Experimentation Training Course (equivalent to FELASA B) (15h) (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2011
Concluded
 Workshop “Entrepreneurship for Engineers” (40h) (Outros)
Universidade do Porto, Portugal
2011
Concluded
 Workshop “Patents and Technology Transfer in Health” (Outros)
Universidade do Porto, Portugal
2006
Concluded
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Hematopoietic stem/progenitor cell expansion on membrane systems" (THESIS/DISSERTATION)
 Aprovado
2001
Concluded
 Engenharia Química, ramo Biotecnologia (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2020/01/01 - 2020/08/31 Auxiliary Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2015/07/01 - 2019/12/31 Auxiliary Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2018/01/01 - 2018/08/31 Visiting Researcher (Research) Universität Ulm, Germany
2014/01/01 - 2015/06/30 Auxiliary Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2013/01/01 - 2013/12/31 Postdoc (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2009/02/01 - 2012/12/31 Auxiliary Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2007/02/01 - 2009/01/31 Postdoc (Research) Instituto Nacional de Engenharia Biomédica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/09/15 - Current Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/09/15 - 2019/02 Visiting Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/09/15 - 2018/12 Visiting Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2016 Invited Assistant (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014 Invited Assistant (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014 Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014 Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010/09/01 - 2012/07/31 Invited Assistant (University Teacher) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Other Careers

Category
Host institution 		Employer
2006/03/01 - 2007/01/31 Técnico Superior (Técnico Superior) Bioteca Preservação de Células Estaminais SA, Portugal

Others

Category
Host institution 		Employer
2001/03/01 - 2002/06/30 Visiting Student University of Nevada, United States
Projects

Grant

Designation Funders
2013/01/01 - 2013/12/31 STEM CELL RECRUITMENT AS A STRATEGY FOR TISSUE REGENERATION
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F856512%F2012/PT
SFRH/BPD/85651/2012
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2010/02 - 2013/08 Incorporation of inflammatory signals in the development of biomaterials for bone repair/regeneration: an integrated approach
99954
Provided by PTCRIS: 99954
 Fundação para a Ciência e a Tecnologia, I.P.
2008/09/01 - 2009/01/31 Influence of the surface on leukemic cell behaviour
SFRH/BPD/36135/2007
Post-doc Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2019/02/01 - Current RESTORE, User-centred smart nanobiomaterial-based 3D matrices for chondral repair
SEP-210512810
Researcher
Horizon 2020
2019/01/01 - Current AbSCisSA - Disclosing hemAtopoietic Stem Cell Self- renewAl at the developing fetal liver intersection
POCI-01-0145- FEDER-032656
Researcher
Fundação para a Ciência e a Tecnologia
2019/01/01 - Current MAGICIAM: a MAcrophaGe Immunomodulatory-delivery system to prevent Cancer Invasion And Metastasis
POCI-31859
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/11/01 - Current Non-coding RNA-based therapies for bone regeneration
POCI-01-0145-FEDER-031402
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/01 - Current Repurposing CRISPR for disc regeneration
05_2018
Researcher
2017/09/01 - Current Disc Regeneration, Immuno- and Neuro- modulation
EUROSPINE_5_2017
Principal investigator
Instituto Nacional de Engenharia Biomédica, Portugal
2015/07/01 - Current Approaching IVD regeneration by MSCs recruitment*
IF/00638/2014
Principal investigator
Fundação para a Ciência e a Tecnologia
2022/03/01 - 2024/02/29 Bioengineering extracellular matrix-based 3D models with aligned fibers to understand intervertebral disc herniation
2021.09716.CBM
Principal investigator
Deutscher Akademischer Austauschdienst
Ongoing
2021/03/01 - 2024/02/29 Biomateriais hierárquicos de inspiração fetal para regeneração num microambiente severo: o núcleo do disco intervertebral FETBIO
PTDC/BTM-MAT/0438/2020
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2023/12/31 Rewinding the clock: CRISPR-mediated NP cell editing for IVD rejuvenation
20-165
Researcher
EUROSPINE The Spine Society of Europe
Ongoing
2022/01/01 - 2023/06/30 Solução com inspiração fetal para a regeneração do Disco Intervertebral utilizando CRISPR para a edição de MSCs
EXPL/BTM-ORG/0880/2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/26 - 2022/07/25 Expansão de células estaminais hematopoiéticas no desenvolvimento: a intersecção fígado fetal-hematopoiese
PTDC/MED-OUT/32656/2017
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2022/05/31 RNA não codificante: uma nova ferramenta terapeutica na regeneração óssea
PTDC/BTM-TEC/31402/2017
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/26 - 2022/04/25 Expansão de células estaminais hematopoiéticas no desenvolvimento: a intersecção fígado fetal-hematopoiese
PTDC/MED-OUT/32656/2017
Instituto Nacional de Engenharia Biomédica, Portugal

Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/15 - 2022/04/14 MAGICIAM: um sistema imunomodelador de macrófagos para prevenir a invasão e metastização das células tumorais
PTDC/BTM-SAL/31859/2017
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10/15 - 2021/10/14 MAGICIAM: um sistema imunomodelador de macrófagos para prevenir a invasão e metastização das células tumorais
PTDC/BTM-SAL/31859/2017
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/01/01 - 2021/03/31 Estaminalidade das células do cancro: um desafio e uma oportunidade para avançar no tratamento em Oncologia
SAICTPAC/0022/2015
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/12/01 - 2021/02/28 Novos alvos na insuficiência cardíaca diastólica: das comorbilidades à medicina personalizada
SAICTPAC/0047/2015
Universidade do Porto Faculdade de Medicina, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/01/01 - 2019/12/31 Integrated Program on Advanced Bioengineering Therapies
NORTE-01-0145-FEDER-000012
Researcher
Comissao de Coordenacao e Desenvolvimento Regional do Norte
2015/07/01 - 2019/12/31 Approaching intervertebral disc regeneration by mesenchymal stem cells recruitment
IF/00638/2014/CP1242/CT0001
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015/09/01 - 2016/08/31 Stem Cells Paracrine Action for IVD
EUROSPINE TRF_2015
Principal investigator
2013/01/01 - 2015/12/31 Project on Biomedical Engineering for Regenerative Therapies and Cancer
NORTE-07-0124-FEDER-000005
Researcher
Comissao de Coordenacao e Desenvolvimento Regional do Norte
2014/06/01 - 2015/09/30 Explorar a resposta imune para uma mais eficaz regeneração de tecidos com biomateriais
EXPL/BIM-MED/0022/2013
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/06/01 - 2015/09/30 Explorar a resposta imune para uma mais eficaz regeneração de tecidos com biomateriais
EXPL/BIM-MED/0022/2013
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/07/01 - 2014/06/30 New disc regeneration therapies in organ culture
Acções Integradas Luso Alemãs 2015
Principal investigator
2013/02/01 - 2013/12/31 STEM CELL RECRUITMENT AS A STRATEGY FOR TISSUE REGENERATION
SFRH/BPD/85651/2012
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Mesenchymal Stem Cell Chemo-Attractive Scaffolds for Intervertebral Disc Regeneration – In Vitro Studies using a Whole Organ Culture System
AOSRN-104979
Researcher
AO Foundation
2010/02/05 - 2013/08/04 Incorporação de sinais inflamatórios em biomateriais: uma estratégia integradora para promover a reparação/regeneração óssea
PTDC/SAU-BEB/099954/2008
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/12/31 Incorporation of inflammatory signals in the development of biomaterials for bone repair/regeneration: an integrated approach
PTDC/SAU-BEB/099954/2008
Researcher
Fundação para a Ciência e a Tecnologia
2008/11/01 - 2012/12/31 Novel biofunctional high porous polymer scaffolds and techniques controlling angiogenesis for the regeneration and repair of the degenerated intervertebral disc
213904
Researcher
European Commission Seventh Framework Programme for Research and Technological Development
2007/02/01 - 2009/12/31 PROTEIN-Immobilization of ligands to albumin and trombin on self-assembled monolayers-influence on thrombus formation and inflammatory reactions
POCTI/CTM/55644/2004
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
2007/10/01 - 2009/01/31 INFLUENCE OF THE SURFACE ON LEUKEMIC CELL BEHAVIOR
SFRH/BPD/36135/2007
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/10/01 - 2009/01/31 INFLUENCE OF THE SURFACE ON LEUKEMIC CELL BEHAVIOR
SFRH/BPD/36135/2007
 Fundação para a Ciência e a Tecnologia
Concluded
2005/01 - 2008/12 Friction and wear mechanisms in orthopaedic prostheses: influence of the composition of the periprosthetic fluid
POCI/SAU-BMA/55493/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Centro de Apoio Tecnológico à Indústria Metalomecânica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/05/02 - 2008/06/30 Imobilização de ligandos para albumina e trombina em monocamadas auto-estruturadas - influência na coagulação e em reacções inflamatórias
POCI/CTM/55644/2004
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/05/02 - 2008/06/30 Imobilização de ligandos para albumina e trombina em monocamadas auto-estruturadas - influência na coagulação e em reacções inflamatórias
POCI/CTM/55644/2004
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/04/01 - 2007/12/31 Mecanismos de atrito e desgaste em próteses ortopédicas: influência da composição do líquido periprostético.
POCI/SAU-BMA/55493/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Centro de Apoio Tecnológico à Indústria Metalomecânica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002/01/01 - 2006/12/31 Ex-vivo Expansion of Hematopoietic Stem Cells in an Immobilized Fluidized Bed Stromal Cell Reactor
POCTI/BIO/37641/2001
Other
Fundação para a Ciência e a Tecnologia
2002/01/01 - 2006/12/31 Design, Operation and Modelling of a Ceramic Membrane Stromal Cell Reactor for Hematopoietic Stem Cell Culture
POCTI/38063/EQU/2001
Other
Fundação para a Ciência e a Tecnologia
2002/01/01 - 2005/12/31 DESIGN AND OPERATION OF A MEMBRANE STROMAL CELL REACTOR FOR HEMATOPOIETIC STEM CELL CULTURE
SFRH/BD/6209/2001
University of Nevada Reno, United States
 Fundação para a Ciência e a Tecnologia
Concluded
2002/01/01 - 2005/12/31 DESIGN AND OPERATION OF A MEMBRANE STROMAL CELL REACTOR FOR HEMATOPOIETIC STEM CELL CULTURE
SFRH/BD/6209/2001
University of Nevada Reno, United States
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2017/01/01 - 2018/12/31 Biomechanics of IVD treated with Anti-inflammatory Therapies
A_09/2017
Principal investigator
Outputs

Publications

Book chapter
  1. Santos, S. G.; Gonçalves, R. M.; Caldeira, J.; Barbosa, M. A.; Oliveira, M. J.. "CHAPTER 10. Immunomodulatory Function of Extracellular Vesicles in Cancer and Tissue Repair/Regeneration". In Biomaterials Science Series, 246-270. Royal Society of Chemistry, 2021.
    10.1039/9781839164552-00246
  2. Gonçalves, Raquel; Teixeira, G.Q.; Barbosa, M.A.. "Immunomodulation in degenerated intervertebral disc". In Gene and Cell Delivery for Intervertebral Disc Degeneration. CRC Press, 2018.
  3. Gonçalves, Raquel; Leite Pereira, C.; Grad, S.; Barbosa, M.A.. "Cell recruitment for degenerated intervertebral disc". In Gene and Cell Delivery for Intervertebral Disc Degeneration. CRC Press, 2018.
  4. Barbosa, M.A.; Gonçalves, I.C.; Moreno, P.M.D.; Gonçalves, R.M.; Santos, S.G.; Pêgo, A.P.; Amaral, I.F.. "2.13 Chitosan?". 279-305. 2017.
  5. Gonçalves, Raquel; Lobato Da Silva, C.; Lemos, M.A.N.D.A.; Lemos, F.; Zanjani, E.D.; Almeida-Porada, G.; Cabral, J.M.S.. "Live catalysis-New fields for theory and experimentation". In Principles and Methods for Accelerated Catalyst Design and Testing, 439-446. Springer Netherlands, 2002.
Conference paper
  1. Pereira, C.L.; Gonçalves, R.M.; Ferreira-Da-silva, F.; Antunes, J.C.; Molinos, M.; Barbosa, M.A.. "Biosynthesis of poly-¿-glutamic acid and its application in the development of chitosan/poly-¿-glutamic acid nanoparticles for drug delivery". 2011.
  2. Gonçalves, R.; Martins, M.C.L.; Almeida -Porada, G.; Barbosa, M.. "Functionalization of self -assembled monolayers with the repeate d unit of notch ligands". 2008.
Conference poster
  1. Morena Fiordailisi; Gonçalves, Raquel. "FETAL EXTRACELLULAR MATRIX OF NUCLEUS PULPOSUS AS A NATURAL SCAFFOLD FOR INTERVERTEBRAL DISC REJUVENATION". Paper presented in Biospine, Roma, Itália, 2019.
  2. Gonçalves, Raquel; Joana R. Ferreira. "A ROLE FOR MSCS SECRETOME TO MODULATE THE INFLAMMATORY RESPONSE IN DISC". Paper presented in 1st International Symposia Secretome Without Borders, 2018.
  3. Gonçalves, Raquel. "The immunomodulatory role of Chitosan (Ch)/ Poly(gamma)-glutamic acid (PGA)-based nanoparticles: individual contribution of Ch and PGA". Paper presented in 29th Annual Meeting of the European Society of Biomaterials, 2018.
  4. Graciosa Teixeira; Gonçalves, Raquel. "Regional differences in terminal complement complex (TCC) deposition suggest a correlation with degenerative changes of intervertebral disc endplates". Paper presented in 11th International Conference on Complement Therapeutics, Creta, Grécia, 2018.
  5. Gonçalves, Raquel. "Rat intervertebral disc degeneration and herniation model for local biomaterial delivery". Paper presented in 28th Annual Meeting of the European Society of Biomaterials, Atenas, Grécia, 2017.
  6. Joana R. Ferreira; Gonçalves, Raquel. "Dissecting Mesenchymal Stem/Stromal Cells Secretome to modulate the inflammatory response of degenerated Intervertebral Disc". Paper presented in TERMIS European Chapter Meeting, Davos, Switzerland, 2017.
  7. Gonçalves, Raquel. "Immunomodulatory properties of MSCs secretome towards macrophages in the context of intervertebral disc degeneration". Paper presented in 6th Interrogations at the Biointerface Summer School, The Research/Clinical Interface at the Spine, 2017.
  8. Pereira, A.C.L.; Gonçalves, Raquel. "An hydrogel to guide cells navigation in intervertebral disc towards regeneration". Paper presented in 6th China-Europe Symposium in Biomaterials for Regenerative Medicine, Porto, PT, 2017.
  9. Joana R. Ferreira; Gonçalves, Raquel. "Towards the use of Mesenchymal Stem/Stromal Cells secretome to modulate the inflammatory response in intervertebral disc degeneration". Paper presented in 6th China-Europe Symposium in Biomaterials for Regenerative Medicine, May, Porto, 2017.
  10. Gonçalves, Raquel; Vasconcelos, D.M.. "Modulation of in vivo immune response – a feasible strategy for improving bone repair/regeneration". Paper presented in World Biomaterials Congress, Montreal, Canadá, 2016.
  11. Leite Pereira, C.; Gonçalves, Raquel. "Bioimaging Tools Towards the Quantification of Extracellular Matrix Production in Degenerating Intervertebral Disc". Paper presented in 4th Symposium in Applied Bioimaging, Porto, PT, 2015.
  12. Flávia Castro; Gonçalves, Raquel. "An Interferon-¿-delivery system based on chitosan/poly(¿-glutamic acid) nanoparticles as cancer immunotherapy". Paper presented in Advanced Summer Course Interrogations at the Biointerface; The nano/medicine interface, Porto, 2015.
  13. Pereira, A.C.L.; Gonçalves, Raquel. "Mesenchymal Stem migration in the intervertebral disc: a new route for regeneration through the activation of endogenous cells and increased matrix production". Paper presented in Advanced Summer Course Interrogations at the Biointerface; The nano/medicine interface, Porto, 2015.
  14. Teixeira, G.Q.; Gonçalves, Raquel. "Simulation of degenerative and pro-inflammatory conditions for testing of cell therapy approaches in a disc organ culture system". 2014.
  15. Caldeira, J.; Gonçalves, Raquel. "On the path to autologous IVD regeneration?". Paper presented in World Spine Forum Research 2014, Xi’ an, China, 2014.
  16. Pereira, A.C.L.; Gonçalves, Raquel. "Stromal Cell Derived Factor-1-delivery system: a new approach for the recruitment of Mesenchymal Stem Cells in degenerating intervertebral disc". Paper presented in World Spine Forum Research 2014, Xi’ an, China, 2014.
  17. Neidlinger-Wilke, C.; Gonçalves, Raquel. "Constrained intervertebral disc organ culture for simulation of cell therapy approaches". Paper presented in EuroSpine 2013 Meeting, Liverpool, UK, 2013.
  18. Cardoso, A.P.; Gonçalves, Raquel. "The effect of interferon-gamma in the reversion of macrophage phenotype". Paper presented in Advanced Summer School Inflammation/Repair Interface, Porto, 2013.
  19. Molinos, M.; Gonçalves, Raquel. "Prospective identification of cell subpopulations on nucleus pulposus of intervertebral disc". Paper presented in Advanced Summer School Inflammation/Repair Interface, Porto, 2013.
  20. Leite Pereira, C.; Gonçalves, Raquel. "Chemoattractant Delivery System for Mesenchymal Cells Recruitment to Intervertebral Disc". Paper presented in Advanced Summer School Inflammation/Repair Interface, Porto, 2013.
  21. Costa, Pedro; Gonçalves, Raquel. "Development of Notch-based polymeric biomaterials as a platform to study Notch Pathway". Paper presented in 20th SIICUSP (Simpósio Internacional de Iniciação Científica da Universidade de São Paulo); São Paulo, Brazil, 2012.
  22. Leite Pereira, C.; Gonçalves, Raquel. "Development of a chemoattractant-delivery system for MSCs recruitment in the degenerated intervertebral disc". Paper presented in 20th Annual meeting of the European Orthopaedic Research Society, Amsterdam, 26-28 Sept 2012, 2012.
  23. Molinos, M.; Gonçalves, Raquel. "How are bovine nucleus pulposus cell populations affected by cell isolation methods? Deepening the knowledge on IVD de(re)generation mechanisms". Paper presented in World Forum for Spine Research 2012: The Intervertebral Disc—from Degeneration to Pain, Helsinki, Finland, 2012.
  24. Leite Pereira, C.; Gonçalves, Raquel. "Development of Chitosan/ Poly-gamma-Glutamic Acid Nanoparticles as an anti-inflammatory drug delivery for intervertebral disc". Paper presented in 9th World Biomaterials Conference, Chengdu, China, 2012.
  25. Lourenço, A.H.; Gonçalves, Raquel. "The Influence of Cell Density and Culture Conditions Within 3d Hydrogel Matrices on Mesenchymal Stem Cells Behavior". Paper presented in 9th World Biomaterials Conference, Chengdu, China, 2012.
  26. Gonçalves, Raquel. "Mesenchymal Stem Cell recruitment by Stromal Derived Factor-1-delivery systems based on Chitosan/Poly(gamma-glutamic acid) Polyelectrolyte Complexes". Paper presented in 7th International Meeting of the Portuguese Society of Stem Cells & Cell Therapies, Porto, 2012.
  27. Antunes, Joana; Gonçalves, Raquel. "Buildup of chitosan and poly-gamma-glutamic acid polyelectrolyte complexes by layer-by-layer deposition". Paper presented in Advanced Summer School, Interrogations at the Biointerface meeting: “The cancer/regeneration interface”, Porto, 2011.
  28. Cardoso, A.P.; Gonçalves, Raquel. "Knowing the enemy: macrophage contribution to gastric cancer cell invasion and angiogenesis". Paper presented in Advanced Summer School, Interrogations at the Biointerface meeting: “The cancer/regeneration interface”, 2011.
  29. Leite Pereira, C.; Gonçalves, Raquel. "Biosynthesis of poly-gamma-polyglutamic acid and its application on the development of chitosan/PGA nanoparticles for drug delivery". Paper presented in Advanced Summer School, Interrogations at the Biointerface meeting: “The cancer/regeneration interface”, 2011.
  30. Lourenço, A.H.; Gonçalves, Raquel. "Behavior of 3D cultured hMSC under basal and osteogenic conditions". Paper presented in Advanced Summer School, Interrogations at the Biointerface meeting: “The cancer/regeneration interface”, 2011.
  31. Galante, João N.; Gonçalves, Raquel. "Development of Notch signaling biomaterials as a tool to control cell behavior". Paper presented in Advanced Summer School, Interrogations at the Biointerface meeting: “The cancer/regeneration interface”, Porto, 2011.
  32. Cardoso, A.P.; Gonçalves, Raquel. "Macrophages stimulate gastric cancer cell invasion". Paper presented in European Association for Cancer Research Special Conference: Inflammation and Cancer, Berlin, Germany, 2009.
  33. Antunes, J.C.; Gonçalves, Raquel. "Ch-based Polyelectrolyte Complexes for Tissue Engineering Applications". Paper presented in 10th Advanced Summer Course in Cell-Material Interactions, Porto, 2009.
  34. Cardoso, A.P.; Gonçalves, Raquel. "Role of macrophages on gastric cancer cell invasion". Paper presented in 10th Advanced Summer Course in Cell Material-Interactions, Porto, Portugal, 2009.
  35. Gonçalves, Raquel. "Jagged-1 Nanostructured Surfaces are able to induce Apoptosis and Differentiation of Leukemic Cells". Paper presented in Notch and Cancer Meeting, Greece, Athens, 2008.
  36. Dos Santos, F.; Gonçalves, Raquel; Lobato Da Silva, C.. "Maximization of the ex-vivo expansion of umbilical cord blood hematopoietic stem/progenitor cells by direct contact culture with human mesenchymal stem cells". Paper presented in 7th Ed ESBES, Faro, 2008.
  37. Gonçalves, Raquel. "Development of Nanostructured Surfaces to Induce Apoptosis of Leukemic Cells". 2008.
  38. Lobato Da Silva, C.; Gonçalves, Raquel. "Defining culture conditions to maximize the ex vivo expansion of human umbilical cord blood hematopoietic stem/progenitor cells: how to start?". 2007.
  39. Gonçalves, Raquel. "Influence of the surface on leukemic cell behavior: preliminary work". Paper presented in 8th Advanced Summer Course in Cell-Materials Interactions, Porto, Portugal, 2007.
  40. Gonçalves, Raquel. "Expansion of human hematopoietic stem/progenitor cells with a supportive stromal layer: implications on bioreactor design". Paper presented in Annual Meeting of the International Society of Stem Cell Research, San Francisco, USA, 2005.
  41. Gonçalves, Raquel. "Spontaneous and transient direct contact of haematopoietic cells with a supportive stromal layer:implications on bioreactor design for cell expansion". Paper presented in 19th Meeting of European Society for Animal Cell Technology, Harrogate, UK, 2005.
  42. Contador, C; Gonçalves, Raquel. "Effects of human stroma on the ex-vivo expansion of human hematopoietic cells assessed by a simple two-parameter kinetic model". Paper presented in 12th International Biotechnology Symposium and Exhibition, Santiago, Chile, 2004.
  43. Lobato Da Silva, C.; Gonçalves, Raquel. "Ex-vivo expansion/maintenance and differentiation of human hematopoietic stem cells in stroma based culture systems". Paper presented in 12th International Biotechnology Symposium and Exhibition (BIOTECHNOLOGY 2004), Santiago, Chile, 2004.
  44. Ferreira, B.S.; Gonçalves, Raquel. "Effects of inoculum and human stroma on the ex-vivo expansion of human hematopoietic cells". Paper presented in European Symposium on Biochemical Engineering Science – 5, Stuttgart, Germany, 2004.
  45. Gonçalves, Raquel; Lobato Da Silva, C.. "Quantitative Analysis of CD34+ Cell Phenotype Enrichment on the Ex vivo Expansion of Human Hematopoietic Stem/Progenitor Cells". Paper presented in European Symposium on Biochemical Engineering Science – 5, Stuttgart, Germany, 2004.
  46. Lobato Da Silva, C.; Gonçalves, Raquel. "Ex-vivo Expansion/Maintenance of Human Hematopoietic Stem Cell Populations in a Stroma-based Culture System". Paper presented in Keystone Symposia Hematopoiesis, Tahoe City, California, USA, 2004.
  47. Gonçalves, Raquel. "A Human Universal Supportive Layer for the Ex-vivo Expansion/Maintenance of Bone Marrow Hematopoietic Stem/Progenitor Cells". Paper presented in Keystone Symposia Stem Cells, Keystone, Colorado, USA, 2004.
  48. Gonçalves, Raquel. "x-Vivo Expansion/Maintenance of Human Hematopoietic Stem Cells Depends on Cell Cycle Status". Paper presented in 11th European Congress on Biotechnology, Basel, Switzerland, 2003.
  49. Lobato Da Silva, C.; Gonçalves, Raquel. "Divergence in Kinetic Division Performance of the Ex-vivo Expansion/Maintenance of Human Hematopoietic Stem/Progenitor Cells from Bone Marrow and Cord Blood". Paper presented in 11th European Congress on Biotechnology, Basel, Switzerland, 2003.
  50. Ferreira, B.S.; Gonçalves, Raquel. "The Ex-Vivo Expansion/Maintenance of Human Hematopoietic Stem/Progenitor Cells Supported by Human Stroma-Based Systems is Determined by Inoculum Quality and Density". Paper presented in 11th European Congress on Biotechnology, Basel, Switzerland, 2003.
  51. Cabral, J.M.S.; Gonçalves, Raquel. "noculum Quality and Density are Determinant to the Ex-vivo Expansion/Maintenance of Human Hematopoietic Stem/Progenitor Cells Supported by Human Stroma-based Systems". Paper presented in Biochemical Engineering (XIII), Boulder, Colorado, USA, 2003.
  52. Lobato Da Silva, C.; Gonçalves, Raquel. "Differing Ex-vivo Expansion Kinetics of Human Adult Bone Marrow (BM) and Cord Blood (CB) Hematopoietic Stem/Progenitors Cells". Paper presented in 32nd Annual Meeting of the International Society for Experimental Hematology (ISEH), Paris, France, 2003.
  53. Lobato Da Silva, C.; Gonçalves, Raquel. "Modelling of Ex-vivo Expansion/Maintenance of Hematopoietic Stem Cells". Paper presented in European Symposium on Biochemical Engineering Science – 4, Delft, The Netherlands, 2002.
Edited book
  1. Gonçalves, Raquel. Gene and Cell Delivery for Intervertebral Disc Degeneration. CRC Press. 2018.
Journal article
  1. Catarina Leite Pereira; Sibylle Grad; Raquel M. Gonçalves. "Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment". JOR SPINE (2023): https://doi.org/10.1002/jsp2.1280.
    10.1002/jsp2.1280
  2. Maria Molinos; Morena F. Fiordalisi; Joana Caldeira; Catarina R. Almeida; Mário A. Barbosa; Raquel M. Gonçalves. "Alterations of bovine nucleus pulposus cells with aging". Aging Cell (2023): https://doi.org/10.1111/acel.13873.
    10.1111/acel.13873
  3. Maura Cimino; Paula Parreira; Victoria Leiro; Aureliana Sousa; Raquel M. Gonçalves; Cristina C. Barrias; M. Cristina L. Martins. "Enhancement of hMSC In Vitro Proliferation by Surface Immobilization of a Heparin-Binding Peptide". Molecules (2023): https://doi.org/10.3390/molecules28083422.
    10.3390/molecules28083422
  4. Teixeira, G.Q.; Riegger, J.; Gonçalves, R.M.; Risbud, M.V.. "Editorial: Intervertebral disc degeneration and osteoarthritis: mechanisms of disease and functional repair". Frontiers in Bioengineering and Biotechnology 11 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85167513349&partnerID=MN8TOARS.
    10.3389/fbioe.2023.1252703
  5. A. L. Castro; C. Ribeiro-Machado; C. M. Oliveira; G. Q. Teixeira; C. Neidlinger-Wilke; P. Pereira; R. Vaz; M. A. Barbosa; R. M. Gonçalves. "Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation". Arthritis Research & Therapy (2022): https://doi.org/10.1186/s13075-021-02690-w.
    10.1186/s13075-021-02690-w
  6. Morena Francesca Fiordalisi; Joana Rita Ferreira; Marta Laranjeiro Pinto; Cláudia Ribeiro-Machado; Marta Teixeira Pinto; Maria José Oliveira; Mário Adolfo Barbosa; Raquel Madeira Gonçalves; Joana Caldeira. "The impact of matrix age on intervertebral disc regeneration". Biomaterials Advances 143 (2022): 213192-213192. http://dx.doi.org/10.1016/j.bioadv.2022.213192.
    10.1016/j.bioadv.2022.213192
  7. Gonçalves, Raquel M.; Saggese, Taryn; Yong, Zhiyao; Ferreira, Joana R.; Ignatius, Anita; Wilke, Hans-Joachim; Neidlinger-Wilke, Cornelia; Teixeira, Graciosa Q.. "Interleukin-1ß More Than Mechanical Loading Induces a Degenerative Phenotype in Human Annulus Fibrosus Cells, Partially Impaired by Anti-Proteolytic Activity of Mesenchymal Stem Cell Secretome". Frontiers in Bioengineering and Biotechnology 9 (2022): http://dx.doi.org/10.3389/fbioe.2021.802789.
    10.3389/fbioe.2021.802789
  8. V. Lima, B.; Oliveira, M.J.; Barbosa, M.A.; Gonçalves, R.M.; Castro, F.. "Harnessing chitosan and poly-(¿-glutamic acid)-based biomaterials towards cancer immunotherapy". Materials Today Advances 15 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130370826&partnerID=MN8TOARS.
    10.1016/j.mtadv.2022.100252
  9. Fiordalisi, MF; Silva, AJ; Barbosa, M; Gonçalves, RM; Caldeira, J. "Intervertebral disc decellularisation: progress and challenges". European Cells and Materials 42 (2021): 196-219. http://dx.doi.org/10.22203/ecm.v042a15.
    10.22203/ecm.v042a15
  10. Carla Cunha; Catarina Leite Pereira; Joana R. Ferreira; Cláudia Ribeiro-Machado; Sibylle Grad; Susana G. Santos; Raquel M. Gonçalves. "Therapeutic Strategies for IVD Regeneration through Hyaluronan/SDF-1-Based Hydrogel and Intravenous Administration of MSCs". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22179609.
    10.3390/ijms22179609
  11. Lai, A.; Gansau, J.; Gullbrand, S.E.; Crowley, J.; Cunha, C.; Dudli, S.; Engiles, J.B.; et al. "Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section". JOR Spine 4 2 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106410930&partnerID=MN8TOARS.
    10.1002/jsp2.1150
  12. Teixeira, G.Q.; Yong, Z.; Kuhn, A.; Riegger, J.; Goncalves, R.M.; Ruf, M.; Mauer, U.M.; et al. "Interleukin-1ß and cathepsin D modulate formation of the terminal complement complex in cultured human disc tissue". European Spine Journal 30 8 (2021): 2247-2256. http://www.scopus.com/inward/record.url?eid=2-s2.0-85108534448&partnerID=MN8TOARS.
    10.1007/s00586-021-06901-5
  13. Neidlinger-Wilke, C.; Ekkerlein, A.; Goncalves, R.M.; Ferreira, J.R.; Ignatius, A.; Wilke, H.J.; Teixeira, G.Q.. "Mesenchymal stem cell secretome decreases the inflammatory response in annulus fibrosus organ cultures". European cells & materials 41 (2021): 1-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110939140&partnerID=MN8TOARS.
    10.22203/eCM.v042a01
  14. Ferreira, J.R.; Teixeira, G.Q.; Neto, E.; Ribeiro-Machado, C.; Silva, A.M.; Caldeira, J.; Leite Pereira, C.; et al. "IL-1ß-pre-conditioned mesenchymal stem/stromal cells' secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc". European cells & materials 41 (2021): 431-453. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105699150&partnerID=MN8TOARS.
    10.22203/eCM.v041a28
  15. Lima, B.V.; Oliveira, M.J.; Barbosa, M.A.; Goncalves, R.M.; Castro, F.; Beatriz Vargas Lima; Maria José Oliveira; et al. "Immunomodulatory potential of chitosan-based materials for cancer therapy: A systematic review of: In vitro, in vivo and clinical studies". Biomaterials Science 9 9 (2021): 3209-3227. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105514424&partnerID=MN8TOARS.
    Accepted • 10.1039/d0bm01984d
  16. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Serre, Karine; Barbosa, Mário A.; Vermaelen, Karim; Gärtner, Fátima; et al. "Chitosan/¿-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer". Biomaterials 257 (2020): 120218. http://dx.doi.org/10.1016/j.biomaterials.2020.120218.
    10.1016/j.biomaterials.2020.120218
  17. Teixeira, Graciosa Q.; Yong, Zhiyao; Goncalves, Raquel M.; Kuhn, Amelie; Riegger, Jana; Brisby, Helena; Barreto Henriksson, Helena; et al. "Terminal complement complex formation is associated with intervertebral disc degeneration". European Spine Journal 30 1 (2020): 217-226. http://dx.doi.org/10.1007/s00586-020-06592-4.
    10.1007/s00586-020-06592-4
  18. Morena Fiordalisi; Ana João Silva; Mário Barbosa; Raquel Gonçalves; Joana Caldeira. "Decellularized Scaffolds for Intervertebral Disc Regeneration". Trends in Biotechnology 38 9 (2020): 947-951. https://doi.org/10.1016/j.tibtech.2020.05.002.
    10.1016/j.tibtech.2020.05.002
  19. Cimino, Maura; Parreira, Paula; Bidarra, Sílvia J.; Gonçalves, Raquel M.; Barrias, Cristina C.; Martins, M. Cristina L.. "Effect of surface chemistry on hMSC growth under xeno-free conditions". Colloids and Surfaces B: Biointerfaces 189 (2020): 110836. http://dx.doi.org/10.1016/j.colsurfb.2020.110836.
    10.1016/j.colsurfb.2020.110836
  20. Teixeira, José H.; Pereira, Catarina Leite; Almeida, Maria Inês; Teixeira, Graciosa Q.; Gonçalves, Raquel M.; Barbosa, Mário A.; Santos, Susana G.. "Articular Repair/Regeneration in Healthy and Inflammatory Conditions: From Advanced In Vitro to In Vivo Models". Advanced Functional Materials (2020): 1909523. http://dx.doi.org/10.1002/adfm.201909523.
    10.1002/adfm.201909523
  21. Carla Cunha; Graciosa Q. Teixeira; Cláudia Ribeiro-Machado; Catarina L. Pereira; Joana R. Ferreira; Maria Molinos; Susana G. Santos; Mário A. Barbosa; Raquel M. Goncalves. "Modulation of the In Vivo Inflammatory Response by Pro- Versus Anti-Inflammatory Intervertebral Disc Treatments". International Journal of Molecular Sciences 21 5 (2020): 1730-1730. https://doi.org/10.3390/ijms21051730.
    10.3390/ijms21051730
  22. Saggese, T.; Teixeira, G.Q.; Wade, K.; Moll, L.; Ignatius, A.; Wilke, H.-J.; Goncalves, R.M.; Neidlinger-Wilke, C.. "GEORG SCHMORL PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2018: combined inflammatory and mechanical stress weakens the annulus fibrosus: evidences from a loaded bovine AF organ culture". European Spine Journal (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060685110&partnerID=MN8TOARS.
    10.1007/s00586-019-05901-w
  23. Silva, A.J.; Ferreira, J.R.; Cunha, C.; Corte-Real, J.V.; Bessa-Gonçalves, M.; Barbosa, M.A.; Santos, S.G.; Gonçalves, R.M.. "Macrophages down-regulate gene expression of intervertebral disc degenerative markers under a proinflammatory microenvironment". Frontiers in Immunology 10 JUL (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85069037178&partnerID=MN8TOARS.
    10.3389/fimmu.2019.01508
  24. Castro, F.; Pinto, M.L.; Almeida, R.; Pereira, F.; Silva, A.M.; Pereira, C.L.; Santos, S.G.; et al. "Chitosan/poly(¿-glutamic acid) nanoparticles incorporating IFN-¿ for immune response modulation in the context of colorectal cancer". Biomaterials Science 7 8 (2019): 3386-3403. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069760890&partnerID=MN8TOARS.
    10.1039/c9bm00393b
  25. Freitas, J.; Santos, S.G.; Gonçalves, R.M.; Teixeira, J.H.; Barbosa, M.A.; Almeida, M.I.. "Genetically engineered-MSC therapies for non-unions, delayed unions and critical-size bone defects". International Journal of Molecular Sciences 20 14 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070503845&partnerID=MN8TOARS.
    10.3390/ijms20143430
  26. Cimino, M.; Gonçalves, R.M.; Bauman, E.; Barroso-Vilares, M.; Logarinho, E.; Barrias, C.C.; Martins, M.C.L.. "Optimization of the use of a pharmaceutical grade xeno-free medium for in vitro expansion of human mesenchymal stem/stromal cells". Journal of Tissue Engineering and Regenerative Medicine 12 3 (2018): e1785-e1795. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038971432&partnerID=MN8TOARS.
    10.1002/term.2588
  27. Molinos, M.; Cunha, C.; Almeida, C.R.; Gonçalves, R.M.; Pereira, P.; Silva, P.S.; Vaz, R.; Barbosa, M.A.. "Age-Correlated Phenotypic Alterations in Cells Isolated from Human Degenerated Intervertebral Discs with Contained Hernias". Spine 43 5 (2018): E274-E284. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021845784&partnerID=MN8TOARS.
    10.1097/BRS.0000000000002311
  28. Leite Pereira, C.; Quelhas Teixeira, G.; Rita Ferreira, J.; D'Este, M.; Eglin, D.; Alini, M.; Grad, S.; Barbosa, M.A.; Goncalves, R.M.. "Stromal cell derived factor-1-mediated migration of mesenchymal stem cells enhances collagen type II expression in intervertebral disc". Tissue Engineering - Part A 24 23-24 (2018): 1818-1830. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058351369&partnerID=MN8TOARS.
    10.1089/ten.tea.2018.0131
  29. Pinheiro, A.; Silva, A.M.; Teixeira, J.H.; Gonçalves, R.M.; Almeida, M.I.; Barbosa, M.A.; Santos, S.G.. "Extracellular vesicles: intelligent delivery strategies for therapeutic applications". Journal of Controlled Release 289 (2018): 56-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054037596&partnerID=MN8TOARS.
    10.1016/j.jconrel.2018.09.019
  30. Ferreira, J.R.; Teixeira, G.Q.; Santos, S.G.; Barbosa, M.A.; Almeida-Porada, G.; Gonçalves, R.M.. "Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning". Frontiers in immunology 9 (2018): 2837-2837. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058882104&partnerID=MN8TOARS.
    10.3389/fimmu.2018.02837
  31. Cunha, C.; Silva, A.J.; Pereira, P.; Vaz, R.; Gonçalves, R.M.; Barbosa, M.A.. "The inflammatory response in the regression of lumbar disc herniation". Arthritis research & therapy 20 1 (2018): 251-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056278077&partnerID=MN8TOARS.
    10.1186/s13075-018-1743-4
  32. Teixeira, G.Q.; Pereira, C.L.; Ferreira, J.R.; Maia, A.F.; Gomez-Lazaro, M.; Barbosa, M.A.; Neidlinger-Wilke, C.; Goncalves, R.M.. "Immunomodulation of Human Mesenchymal Stem/Stromal Cells in Intervertebral Disc Degeneration". Spine 43 12 (2018): E673-E682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048118371&partnerID=MN8TOARS.
    10.1097/BRS.0000000000002494
  33. Castro, F.; Cardoso, A.P.; Gonçalves, R.M.; Serre, K.; Oliveira, M.J.. "Interferon-gamma at the crossroads of tumor immune surveillance or evasion". Frontiers in Immunology 9 MAY (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85046686322&partnerID=MN8TOARS.
    10.3389/fimmu.2018.00847
  34. Cunha, C.; Lamas, S.; Gonçalves, R.M.; Barbosa, M.A.. "Joint analysis of IVD herniation and degeneration by rat caudal needle puncture model". Journal of Orthopaedic Research 35 2 (2017): 258-268. http://www.scopus.com/inward/record.url?eid=2-s2.0-85005992195&partnerID=MN8TOARS.
    10.1002/jor.23114
  35. Silva, A.M.; Teixeira, J.H.; Almeida, M.I.; Gonçalves, R.M.; Barbosa, M.A.; Santos, S.G.. "Extracellular Vesicles: Immunomodulatory messengers in the context of tissue repair/regeneration". European Journal of Pharmaceutical Sciences 98 (2017): 86-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-85000351063&partnerID=MN8TOARS.
    10.1016/j.ejps.2016.09.017
  36. Castro, F.; Pinto, M.L.; Silva, A.M.; Pereira, C.L.; Teixeira, G.Q.; Gomez-Lazaro, M.; Santos, S.G.; et al. "Pro-inflammatory chitosan/poly(¿-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity". Acta Biomaterialia 63 (2017): 96-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030032238&partnerID=MN8TOARS.
    10.1016/j.actbio.2017.09.016
  37. Antunes, J.C.; Pereira, C.L.; Teixeira, G.Q.; Silva, R.V.; Caldeira, J.; Grad, S.; Gonçalves, R.M.; Barbosa, M.A.. "Poly(¿-glutamic acid) and poly(¿-glutamic acid)-based nanocomplexes enhance type II collagen production in intervertebral disc". Journal of Materials Science: Materials in Medicine 28 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-84996606963&partnerID=MN8TOARS.
    10.1007/s10856-016-5787-1
  38. Cunha, C.; Almeida, C.R.; Almeida, M.I.; Silva, A.M.; Molinos, M.; Lamas, S.; Pereira, C.L.; et al. "Systemic delivery of bone marrow mesenchymal stem cells for in situ intervertebral disc regeneration". Stem Cells Translational Medicine 6 3 (2017): 1029-1039. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017568310&partnerID=MN8TOARS.
    10.5966/sctm.2016-0033
  39. Caldeira, J.; Santa, C.; Osório, H.; Molinos, M.; Manadas, B.; Goncalves, R.; Barbosa, M.. "Matrisome Profiling during Intervertebral Disc Development and Ageing". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85029508543&partnerID=MN8TOARS.
    10.1038/s41598-017-11960-0
  40. Cimino, M.; Gonçalves, R.M.; Barrias, C.C.; Martins, M.C.L.. "Xeno-free strategies for safe human mesenchymal stem/stromal cell expansion: Supplements and coatings". Stem Cells International 2017 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042597689&partnerID=MN8TOARS.
    10.1155/2017/6597815
  41. Oliveira, M.I.; Pinto, M.L.; Gonçalves, R.M.; Martins, M.C.L.; Santos, S.G.; Barbosa, M.A.. "Adsorbed Fibrinogen stimulates TLR-4 on monocytes and induces BMP-2 expression". Acta Biomaterialia 49 (2017): 296-305. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007016045&partnerID=MN8TOARS.
    10.1016/j.actbio.2016.11.034
  42. Vasconcelos, D.M.; Gonçalves, R.M.; Almeida, C.R.; Pereira, I.O.; Oliveira, M.I.; Neves, N.; Silva, A.M.; et al. "Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration". Biomaterials 111 (2016): 163-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991771953&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2016.10.004
  43. Teixeira, G.Q.; Boldt, A.; Nagl, I.; Pereira, C.L.; Benz, K.; Wilke, H.-J.; Ignatius, A.; et al. "A Degenerative/Proinflammatory Intervertebral Disc Organ Culture: An Ex Vivo Model for Anti-inflammatory Drug and Cell Therapy". Tissue Engineering - Part C: Methods 22 1 (2016): 8-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954326138&partnerID=MN8TOARS.
    10.1089/ten.tec.2015.0195
  44. Pereira, C.L.; Teixeira, G.Q.; Ribeiro-Machado, C.; Caldeira, J.; Costa, M.; Figueiredo, F.; Fernandes, R.; et al. "Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988672665&partnerID=MN8TOARS.
    10.1038/srep33836
  45. Teixeira, G.Q.; Leite Pereira, C.; Castro, F.; Ferreira, J.R.; Gomez-Lazaro, M.; Aguiar, P.; Barbosa, M.A.; Neidlinger-Wilke, C.; Goncalves, R.M.. "Anti-inflammatory Chitosan/Poly-¿-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc". Acta Biomaterialia 42 (2016): 168-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983262266&partnerID=MN8TOARS.
    10.1016/j.actbio.2016.06.013
  46. Molinos, M.; Almeida, C.R.; Caldeira, J.; Cunha, C.; Gonçalves, R.M.; Barbosa, M.A.. "Inflammation in intervertebral disc degeneration and regeneration". Journal of the Royal Society Interface 12 104 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923260818&partnerID=MN8TOARS.
    10.1098/rsif.2014.1191
  47. Cardoso, A.P.; Gonçalves, R.M.; Antunes, J.C.; Pinto, M.L.; Pinto, A.T.; Castro, F.; Monteiro, C.; Barbosa, M.A.; Oliveira, M.J.. "An interferon-¿-delivery system based on chitosan/poly(¿-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro". Acta Biomaterialia 23 (2015): 157-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938199069&partnerID=MN8TOARS.
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  48. Molinos, M.; Almeida, C.R.; Gonçalves, R.M.; Barbosa, M.A.. "Improvement of Bovine Nucleus Pulposus Cells Isolation Leads to Identification of Three Phenotypically Distinct Cell Subpopulations". Tissue Engineering - Part A 21 15-16 (2015): 2216-2227. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938500222&partnerID=MN8TOARS.
    10.1089/ten.tea.2014.0461
  49. Silva, A.M.; Varela-Moreira, A.; Gomes, C.P.; Molinos, M.; Leite, M.; Almeida, M.; Ribeiro, D.; et al. "Integrated Analysis of Biological Samples by Imaging Flow Cytometry". Microscopy and Microanalysis 21 (2015): 95-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944073933&partnerID=MN8TOARS.
    10.1017/S1431927615014282
  50. Antunes, J.C.; Tsaryk, R.; Gonçalves, R.M.; Pereira, C.L.; Landes, C.; Brochhausen, C.; Ghanaati, S.; Barbosa, M.A.; Kirkpatrick, C.J.. "Poly(¿-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells". Tissue Engineering - Part A 21 11-12 (2015): 1869-1885. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930157502&partnerID=MN8TOARS.
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  51. Gonçalves, R.M.; Pereira, A.C.L.; Pereira, I.O.; Oliveira, M.J.; Barbosa, M.A.. "Macrophage response to chitosan/poly-(¿-glutamic acid) nanoparticles carrying an anti-inflammatory drug". Journal of Materials Science: Materials in Medicine 26 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84925061574&partnerID=MN8TOARS.
    10.1007/s10856-015-5496-1
  52. Pereira, C.L.; Gonçalves, R.M.; Peroglio, M.; Pattappa, G.; D'Este, M.; Eglin, D.; Barbosa, M.A.; Alini, M.; Grad, S.. "The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs". Biomaterials 35 28 (2014): 8144-8153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903746142&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2014.06.017
  53. Maia, F.R.; Lourenço, A.H.; Granja, P.L.; Gonçalves, R.M.; Barrias, C.C.. "Effect of cell density on mesenchymal stem cells aggregation in RGD-alginate 3D matrices under osteoinductive conditions". Macromolecular Bioscience 14 6 (2014): 759-771. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902536382&partnerID=MN8TOARS.
    10.1002/mabi.201300567
  54. Cardoso, A.P.; Pinto, M.L.; Pinto, A.T.; Oliveira, M.I.; Pinto, M.T.; Gonçalves, R.; Relvas, J.B.; et al. "Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y 1086, c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity". Oncogene 33 16 (2014): 2123-2133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899425243&partnerID=MN8TOARS.
    10.1038/onc.2013.154
  55. Teixeira, G.Q.; Barrias, C.C.; Lourenço, A.H.; Gonçalves, R.M.. "A multicompartment holder for spinner flasks improves expansion and osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds". Tissue Engineering - Part C: Methods 20 12 (2014): 984-993. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913593134&partnerID=MN8TOARS.
    10.1089/ten.tec.2014.0067
  56. Santos, S.G.; Lamghari, M.; Almeida, C.R.; Oliveira, M.I.; Neves, N.; Ribeiro, A.C.; Barbosa, J.N.; et al. "Adsorbed fibrinogen leads to improved bone regeneration and correlates with differences in the systemic immune response". Acta Biomaterialia 9 7 (2013): 7209-7217. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878315890&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.04.008
  57. Gonçalves, R.M.; Antunes, J.C.; Barbosa, M.A.. "Mesenchymal stem cell recruitment by stromal derived factor-1-delivery systems based on chitosan/poly(¿-glutamic acid) polyelectrolyte complexes". European Cells and Materials 23 (2012): 249-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864582297&partnerID=MN8TOARS.
  58. MacIel, J.; Oliveira, M.I.; Gonalves, R.M.; Barbosa, M.A.. "The effect of adsorbed fibronectin and osteopontin on macrophage adhesion and morphology on hydrophilic and hydrophobic model surfaces". Acta Biomaterialia 8 10 (2012): 3669-3677. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865455542&partnerID=MN8TOARS.
    10.1016/j.actbio.2012.06.010
  59. Pereira, C.L.; Antunes, J.C.; Gonçalves, R.M.; Ferreira-Da-Silva, F.; Barbosa, M.A.. "Biosynthesis of highly pure poly-¿-glutamic acid for biomedical applications". Journal of Materials Science: Materials in Medicine 23 7 (2012): 1583-1591. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863314791&partnerID=MN8TOARS.
    10.1007/s10856-012-4639-x
  60. Almeida, C.R.; Vasconcelos, D.P.; Gonçalves, R.M.; Barbosa, M.A.. "Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials". Journal of the Royal Society Interface 9 67 (2012): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856583891&partnerID=MN8TOARS.
    10.1098/rsif.2011.0357
  61. Antunes, J.C.; Pereira, C.L.; Molinos, M.; Ferreira-Da-Silva, F.; Dessi, M.; Gloria, A.; Ambrosio, L.; et al. "Layer-by-layer self-assembly of chitosan and poly(¿-glutamic acid) into polyelectrolyte complexes". Biomacromolecules 12 12 (2011): 4183-4195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856258191&partnerID=MN8TOARS.
    10.1021/bm2008235
  62. Gonçalves, R.; Martins, M.C.L.; Oliveira, M.J.; Almeida-Porada, G.; Barbosa, M.A.. "Bioactivity of immobilized EGF on self-assembled monolayers: Optimization of the immobilization process". Journal of Biomedical Materials Research - Part A 94 2 (2010): 576-585. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953815323&partnerID=MN8TOARS.
    10.1002/jbm.a.32723
  63. Da Silva, C.L.; Gonçalves, R.; Dos Santos, F.; Andrade, P.Z.; Almeida-Porada, G.; Cabral, J.M.S.. "Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34+, CD34+CD38-and early lymphoid CD7+cells". Journal of Tissue Engineering and Regenerative Medicine 4 2 (2010): 149-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649221153&partnerID=MN8TOARS.
    10.1002/term.226
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    10.1002/jcp.21736
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    10.1016/j.biomaterials.2009.09.010
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    10.1007/s10529-005-5932-2
  67. Gonçalves, R.; Lobato da Silva, C.; Cabral, J.M.S.; Zanjani, E.D.; Almeida-Porada, G.. "A Stro-1+ human universal stromal feeder layer to expand/maintain human bone marrow hematopoietic stem/progenitor cells in a serum-free culture system". Experimental Hematology 34 10 (2006): 1353-1359. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748528996&partnerID=MN8TOARS.
    10.1016/j.exphem.2006.05.024
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    10.1007/s00449-002-0308-7

Intellectual property

Patent
  1. Gonçalves, Raquel; Cristina Barrias. 2011. "Container, useful in spinner flask assembly and kit for culturing cell samples in three-dimensional matrix, comprises chambers for containing cell samples, where one of the walls of chambers are perforated to allow culture media and a lid".
Provisional application for patent
  1. 2015. "Preparation of Fibrinogen Scaffolds for tissue regeneration".
  2. 2011. "Biomaterial based delivery system for chemoattraction of stem cells".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/06/03 Is the terminal complement complex a possible target for therapeutic intervention in intervertebral disc degeneration? 46th Annual Meeting of The International Society for the Study of the Lumbar Spine
(Kyoto, Japan)
2019/04/03 MSCs secretome decreases matrix degrading activity of anulus fibrosus cells under mechanical loading and an inflammatory environment BioSpine, 7th International Congress on Biotechnologies for Spine Surgeries
(Rome)
2019/04/03 Dissecting Mesenchymal Stem/Stromal Cells Secretome to modulate the inflammatory response of degenerated Intervertebral Disc Biospine, 7th International Congress on Biotechnologies for Spinal Surgeries
(Rome)
2018/09/09 Development of biomaterials-based immunotherapy: chitosan, poly(gamma)-glutamic and interferon-gamma as key immunomodulatory players 29th Annual Meeting of the European Society of Biomaterials
(Maastricht, Netherlands)
2018/06/18 An in situ anti-inflammatory drug delivery system World Forum for Spine Research 2012: The Intervertebral Disc—from Degeneration to Pain
(Helsinki, Finland)
2017/09/04 Hyaluronan-based hydrogel for SDF-1 delivery in the intervertebral disc: insights from an ex vivo model 28th Annual Meeting of the European Society of Biomaterials
(Athens, Greece)
2017/09/04 Chitosan/Poly-¿-Glutamic acid nanoparticles as the backbone of immunomodulatory therapies 28th Annual Meeting of the European Society of Biomaterials
(Athens, Greece)
2017/06/26 Mesenchymal Stem/Stromal Cells Recruitment from the Cartilaginous Endplate: a new perspective for IVD regenerative strategies through ECM remodeling TERMIS European Chapter Meeting
(Davos, Switzerland)
2017/06/26 Mesenchymal stem/stromal cells immunomodulatory role through a paracrine mechanism in degenerated IVD TERMIS European Chapter Meeting
(Davos, Switzerland)
2017/06/19 Mesenchymal stem/stromal cells immunomodulatory role through a paracrine mechanism in degenerated IVD 6th Interrogations at the Biointerface Summer School, The Research/Clinical Interface at the Spine
(Porto, Portugal)
2017/05/21 Poly(gamma-glutamic acid)-based anti-inflammatory nanoparticles promote extracellular matrix remodeling in intervertebral disc 6th China-Europe Symposium in Biomaterials for Regenerative Medicine
(Porto, Portugal)
2016/10/05 Extracellular Matrix Remodeling in intervertebral Disc by Mesenchymal Stem/Stromal Cells Recruitment from the Cartilaginous Endplate: a new perspective for IVD regenerative strategies Eurospine Meeting
(Berlim, Germany)
2016/10/05 Mesenchymal stem/stromal cells present an immunomodulatory role through paracrine mechanism in degenerated but not in healthy IVD Eurospine Meeting
(Berlim, Germany)
2016/06/28 Intervertebral Disc Regeneration: role of migrating Mesenchymal Stem/Stromal cells (MSCs) in Extracellular Matrix Remodeling Termis European Chapter Meeting
(Uppsala, Sweden)
2016/06/28 Local treatment of inflammation in degenerated intervertebral disc using poly(¿-glutamic acid)-based nanocomplexes promote extracellular matrix remodelling Termis European Chapter Meeting
(Uppsala, Sweden)
2016/04/13 Improvement of Bovine Nucleus Pulposus Cells Isolation Leads to Identification of Three Phenotypically Distinct Cell Subpopulations Global Spine Congress/World Forum for Spine Research
(Dubai, United Arab Emirates)
2016/04/13 A nanotechnology-based therapy to target inflammation in degenerated intervertebral disc: first results from an ex vivo disc organ culture Global Spine Congress/World Forum for Spine Research
(Dubai, United Arab Emirates)
2016/03/05 Tissue Repair and Regeneration: the particular case of the intervertebral disc V AEICBAS Biomedical Congress
2015/04/15 Characterization of the immune response associated with bone regeneration induced by fibrinogen implants American Society for Biomaterials Annual Meeting
(Charlotte, United States)
2015/04/13 An anti-inflammatory drug delivery system based on Chitosan/Poly-(gamma-Glutamic acid) nanoparticles to treat inflammation and degeneration of intervertebral disc: an ex vivo study American Society for Biomaterials Annual Meeting
(Charlotte, United States)
2015/04/13 Intervertebral disc regeneration: the role of MSCs recruitment by hyaluronan-based delivery of SDF-1 in matrix production improvement Biospine
(Berlim, Germany)
2015/04/11 Local treatment of inflammation and degeneration of intervertebral disc: ex vivo study of anti-inflammatory drug delivery system based on Chitosan/Poly-(gamma-Glutamic acid) nanoparticles Biospine
(Berlim, Germany)
2015/04/07 The potencial of Poly(gamma-glutamic acid) in chondrogenesis and on inflammation control 2011 UKSim 5th European Symposium on Computer Modeling and Simulation
IEEE (Hangzhou, China)
2015/04/07 The potencial of Poly(gamma-glutamic acid) in chondrogenesis and on inflammation control 5th China-Europe Symposium on Biomaterials in Regenerative Medicine
(Hangzhou, China)
2014/12/11 Comparison of an anti-inflammatory drug delivery system versus MSC therapy to control inflammation in a pro-inflammatory intervertebral disc organ culture system 9th German Spine Conference
(Leipzig, Germany)
2014/11/06 Ex vivo study of an anti-inflammatory drug delivery system based on Chitosan/Poly-gamma-glutamic acid nanoparticles to control inflammation in intervertebral disc organ cultures Meeting of the German Society for Biomaterials
(Dresden, Germany)
2014/10/28 Simulation of degenerative and pro-inflammatory conditions for testing of cell therapy approaches in a disc organ culture system German Congress of Orthopaedics and Trauma Surgery
(Berlim, Germany)
2014/08/31 Fibrinogen implants for bone regeneration: short- and long-term in vivo responses 26th European Conference on Biomaterials
(Liverpool, United Kingdom)
2014/08/31 Treatment of a degenerative/pro-inflammatory intervertebral disc organ culture with Chitosan/Poly-gamma-glutamic acid nanoparticles carrying and anti-inflammatory drug 26th European Conference on Biomaterials
(Liverpool, United Kingdom)
2013/09/08 Establishment of 3D Cell Cultures Under Dynamic Conditions Using a Multi-compartment Holder for Spinner Flask 25th Meeting of the European Society of Biomaterials
(Madrid, Spain)
2013/09/08 Development of Chemoattractant Delivery System for Mesenchymal Cells Recruitment to Intervertebral Disc 25th Meeting of the European Society of Biomaterials
(Madrid, Spain)
2013/09/08 Fibrinogen adsorption improved bone regeneration and correlated with differences in the systemic immune response 25th Meeting of the European Society of Biomaterials
(Madrid, Spain)
2012/11/23 NEWTherapies for Cartilage@INEB 1ª Jornadas e 4º Curso de Cartilagem Articular, Grupo de Estudo da Cartilagem, Prevenção e Tratamento da Artrose (GECA)
(Lisboa, Portugal)
2012/03/15 Desenvolvimento de um sistema de libertação local de um anti-inflamatório para o disco intervertebral IV Congresso Nacional da Sociedade Portuguesa de Patologia da Coluna Vertebral
(Monte Real, Portugal)
2011/09/07 Biosynthesis of Poly-gamma-Glutamic Acid and its application in the development of Chitosan/Poly-gamma-Glutamic Acid Nanoparticles for Drug Delivery 24th European Conference on Biomaterials
(Dublin, Ireland)
2011/06/07 Enhanced Mesenchymal Stromal Cell recruitment via Natural Killer cells by incorporation of inflammatory signals in biomaterials Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting
(Granada, Spain)
2011/06/07 Development of Chitosan-based delivery system to recruit mesenchymal stem cells Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting
(Granada, Spain)
2011/04/04 Delivery system based on Chitosan/gamma-Poly-glutamic Acid Polyelectrolyte Complexes recruits Mesenchymal Stem Cells 3rd China-Europe Symposium on Biomaterials in Regenerative Medicine
(Najing, China)
2011/03/24 Chemoattraction of Mesenchymal Stem Cells to intravertebral disc: design and characterization of a chemokine delivery system Global Spine Congress 2011
(Barcelona, Spain)
2010/12/16 Tertúlia Investigação - Da vontade à concretização Dept. de Ciência e Relações Internacionais da Associação de Estudantes do Instituto Ciências Biomédicas Abel Salazar
(Porto, Portugal)
2010/09/11 Development of Chitosan/gamma-Polyglutamic Acid Polyelectrolyte Complexes for Intervertebral Disc Regeneration 23rd European Conference on Biomaterials
(Tampere, Finland)
2009/11/27 Biomateriais e Bioreactores Encontro Nacional de Estudantes de Bioquimica
(Covilhã, Portugal)
2009/09/07 Engineering Notch Signaling at the Nanoscale 22nd European Conference on Biomaterials
(Lausanne, Switzerland)
2009/04/29 Modelling the individual – from deterministic to stochastic modelling of cell growth and differentiation 4th International Meeting of the Portuguese Society of Stem Cells and Cell Therapy
(Lisboa, Portugal)
2009/04/29 Design of nanostructured surfaces to induce Notch signaling 4th International Meeting of the Portuguese Society of Stem Cells and Cell Therapy
(Lisboa, Portugal)
2008/09/17 Surface Characterization of Nanostructured Surfaces to Induce Selective Apoptosis of Leukemic Cells 3rd edition of the Iberian Biomaterials Congress
(Barcelona, Spain)
2007/11/20 Tecnologias emergentes do sangue Tertúlia FNAC, "Os segredos do Sangue", Semana da Ciência e Tecnologia
(Porto, Portugal)
2007/08/19 Ex-vivo Expansion of Human Hematopoietic Stem/Progenitor Cells in a Human Stromal-based Culture System American Chemical Society 234th National Meeting & Exposition
(Boston, United States)
2007/04/27 Defining a suitable feeder layer for the co-culture of human umbilizal cord blood hematopoietic stem/progenitor cells 2nd Annual Meeting of Portuguese Society for Stem Cells and Cell Therapies
(Coimbra, Portugal)
2006/05/30 Ex-vivo expansion of human hematopoietic stem cells in stromal-based culture systems 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies
(Funchal, Portugal)
2004/09/08 Ex-vivo expansion/maintenance and differentiation of human hematopoietic stem cells in stroma-based culture systems European Symposium on Biochemical Engineering Science – 5
(Stturgart, Germany)
2003/07/05 A Human Allogeneic Mesenchymal Cell-Based (MSC) Serum-Free Culture System Supports the Ex-Vivo Expansion/Maintenance of Bone Marrow (BM) Hematopoietic Stem/Progenitor Cells (HSC) 32nd Annual Meeting of the International Society for Experimental Hematology (ISEH)
(Paris, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/01/03 - Current Anti-inflammatory nano-enabled scaffolds for mesenchymal stem/stromal cells chondrogenesis and immunomodulatory functions"
Supervisor
 Mestrado em Bioengenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/03 - Current Biological characterization of a decellularized nucleus pulposus (NP)-based hydrogel
Co-supervisor
 Mestrado em Bioengenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - Current Bioengineering a 3D in vitro model of Annulus Fibrosus (Bio3D-AF): dissecting the impact of inflammation and mechanical loading in intervertebral disc herniation
Supervisor
 Programa Doutoral em Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
2019/01/01 - Current Dissecting the role of CCL18 at the tumor microenvironment
Co-supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 - 2022 Anti-inflammatory Nano-enabled Scaffolds for Mesenchymal Stem/Stromal Cells Chondrogenesis and Immunomodulatory Functions
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2021/03/01 - 2021/08/31 Potentiating the pro-regenerative effect of decellularized-based scaffolds for IVD regeneration by combination with MSC secretome
Co-supervisor
 Mestrado de Engenharia Biomédica
Danmarks Tekniske Universitet, Denmark
2021/03/01 - 2021/07/31 Unravelling immunomodulatory therapeutic targets in intervertebral disc degeneration/herniation
Supervisor
 Licenciatura em Bioquímica
Universidade do Porto Faculdade de Ciências, Portugal
2019/09/01 - 2020/12 Molecular mechanisms involved in Chitosan/poly(y-glutamic acid) nanoparticles recognition in macrophages and dendritic cells
Co-supervisor
 Mestrado em Oncologia (Master)
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2020 - 2020 Engineering Chitosan/Poly-(y-glutamic acid) nanoparticles to reshape the tumor microenvironment
Supervisor
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - 2020 Bioengineering of a 3D in vitro model of Annulus Fibrosus: towards dissection of the impact of inflammation and mechanical loading in invertebral disc herniation
Supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/01/01 - 2019/07/11 Targeting antigen-presenting cells: chitosan/poly(¿-glutamic acid) nanoparticles as adjuvants to anticancer therapy
Co-supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/03/01 - 2019/07/10 A perfusable 3D printed device for scalable cultured meat production
Co-supervisor
 Mestrado Integrado em Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2017/11/01 - 2018/10/26 Establishment of a human model of intervertebral disc degeneration and associated immune response
Supervisor
 Mestrado em Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2018/02/01 - 2018/07 Immunomodulatory nanoparticles for intervertebral disc degeneration
Co-supervisor
 Mestrado Integrado em Bioengenharia (Master)
Universidade do Porto, Portugal
2012/01/01 - 2018/01/26 The signature of nucleus pulposus cells in homeostasis and aging
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2018 Establishment of a human model of intervertebral disc degeneration and associated immune response
Supervisor
 Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2018 - 2018 Decellularized fetal nucleus pulposus extracellular matrix for intervertebral disc regeneration
Supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/01/01 - 2017/07/19 MSCs recruitment for IVD regeneration
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017 Exploring Mesenchymal Stem/Stromal Cells Immunomodulatory Potential in Intervertebral Disc Degeneration
Supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2016 Towards the use of mesenchymal stem cells secretome to treat intervertebral disc degeneration
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2014 - 2014 Modulation of inflammatory response associated with intervertebral disc degeneration
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011/09/01 - 2012/03/31 Establishment of 3D cell cultures under dynamic conditions using a multi compartment holder for spinner flask
Supervisor
 Mestrado Engenharia Biomédica (Master)
Universidade Católica Portuguesa, Portugal
2010/09/01 - 2011/07/31 Influence of cell density and culture conditions within 3D hydrogel matrices on MSCs behaviour
Supervisor
 Engenharia Biomédica (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2009/09/01 - 2010/07/31 Development of Notch Signaling Biomaterials as a tool to control stem cell behaviour
Supervisor
 Engenharia Biomédica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2011/06/19 - Current International Symposium in Applied Biomaging (2011/06/19)
2009 - Current 10th Advanced Summer Course in Cell-Material Interactions: "Self-assembly: from nature to clinics" (2009)
Conference (President of the Organising Committee)
 Instituto Nacional de Engenharia Biomédica, Portugal
2020 - 2021 Local Organizing Committee of the 31st Annual Conference of the European Society of Biomaterials (2021/09/05 - 2021/09/09)
Conference
2017/06/19 - 2017/06/22 6th Interrogations at the Biointerface Advanced Summer School, “Research/clinical interface at the Spine”, Porto (2017/06/19)
Conference (President of the Organising Committee)
2007 - 2008 Advanced Summer Course in Cell-Material Interactions (2007 - 2008)
Conference (Member of the Organising Committee)
 Instituto Nacional de Engenharia Biomédica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/09/26 - Current Invited Speaker "Regeneration and Immunomodulation in Disc Degeneration"
Seminar
 IBIMED Seminars
Universidade de Aveiro, Portugal
2018/05/07 - Current Seminar as I3S Science Ambassador
Seminar
 Escola Secundária José Régio, Maia
2017 - Current Seminar as I3S Science Ambassador
Seminar
 Escola Secundária Marco de Canavezes
2017 - Current Seminar as I3S Science Ambassador
Seminar
 Escola Secundária Águas Santas, Matosinhos
2016/11 - Current Invited Speaker, "Tissue Repair and Regeneration: the particular case of the intervertebral disc"
Seminar
 V AEICBAS Biomedical Congress
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2016 Coordinator of scientific dissemination in High Schools of Porto with the program “O INEB vai à escola”
Workshop
Instituto Nacional de Engenharia Biomédica, Portugal
2007 - 2011 Participation in scientific dissemination in Primary Schools of Porto with the program “A turma do osso”
Workshop
Instituto Nacional de Engenharia Biomédica, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12/15 Exploring Mesenchymal Stem/Stromal Cells Immunomodulatory Potential in Intervertebral Disc Degeneration
Supervisor
 Joana Rita Cardoso Brandão e Pinto Ferreira (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/04/06 Contribution of Aging and Senescence to Intervertebral Disc Degeneration Emanuel José Magalhães Novais (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020/07/21 Osteoarticular repair in inflammatory conditions: the impact of rheumatoid arthritis on the acute response to bone injury José Henrique Teixeira (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/07/14 Dissecting the Mechanisms of Notch Signalling in Human HSCs: Implications in Stem Cell Expansion Joana Carmelo (PhD)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2018/11/27 Optimization of an in vitro model for the study of the arthopathy pathogenesis in Hereditary Hemacromathosis
(Thesis) Main arguer
 Paula Costa (Master)
2018/11/17 Towards the Development of a MSC Product with Enhanced Therapeutic Features for Myocardial Infarction
(Thesis) Main arguer
 Diogo Pinto (PhD)
2018/09/19 Dissecting the Niche for HSC Expansion: A Cellular and Molecular Portray at the Developing Haematopoietic System-Foetal Liver Crossroads
(Thesis) Main arguer
 Márcia Peixoto (Master)
2018/05/09 Stem cell engineering approaches towards angiogenic cell therapy for ischemic disease Márcia Mata (PhD)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2017/12/13 Effect of industrial GMP human plasma derived supplement on hMSC behaviour
(Thesis) Arguer
 Maura Cimino (PhD)
2017/07/19 Modulation of Inflammatory Response in Intervertebral Disc Degeneration
Supervisor
 Graciosa Q. Teixeira (PhD)
2017/03/17 Scalable Manufacturing of MSCs for Cells Therapies and the role of the Notch Signaling Patway in the Human Hematopoietic System
(Thesis) Arguer
 António Soure (PhD)
2015/12/07 Synovial MSCs for cartilage repair
(Thesis) Main arguer
 Aruna Santhagunam (PhD)
2015/06/19 Novel immunotherapy strategies with genetically-engineered human MSCs using non-viral vectors
(Thesis) Arguer
 Joana Boura (PhD)
2015/05/14 Generation and characterization of in vitro model systems to study cardiovascular specification and differentiation
(Thesis) Arguer
 Ana Freire (PhD)
2015/02/27 Immunomodulatory activity of MSCs
(Thesis) Main arguer
 Mónica Coelho (PhD)
2014/10/03 The cross-talk between endothelial cells and mesenchymal stem cells in a 3D microenvironment
(Thesis) Main arguer
 David Gomes (Master)
2013/10/25 Antimicrobial peptides against Helicobacter pylori
(Thesis) Main arguer
 Vanessa Graça (Master)
2012/12/03 Isolation and ex-vivo expansion of endothelial progenitor cells from the umbilical cord blood
(Thesis) Main arguer
 Marta Carvalho (Master)
2011/11/22 Valorization of blood sub products for Regenerative Medicine and Stem Cell Research
(Thesis) Main arguer
 Ana Paula Sousa (Master)
2011/07/27 Isolation and ex-vivo expansion of MSCs for supplementation during hematopoietic stem cell transplantation
(Thesis) Main arguer
 Francisco dos Santos (PhD)
2010/10/18 Biosynthesis of poly-gamma-glutamic acid and its application in gamma-PGA/Chitosan nanoparticles
(Thesis) Main arguer
 Ana Catarina Leite Pereira (Master)
2009/12/02 Long-term labeling of MSCs and Chondrocytes in Co-cultures
(Thesis) Main arguer
 Andreia Sofia Rodrigues (Master)
2009/12/02 Bioreactor re-designing and culture conditions study for cartilage tissue engineering
(Thesis) Main arguer
 Inês Costa (Master)
2008/11/14 Ex vivo expansion of human myoblasts and fibroblasts for potencial use in urinary incontinence treatment
(Thesis) Main arguer
 Joana Moura (Master)
2007/09/03 Derivation of Type II Pneumocytes from murine embryonic stem cells: in vivo role in lung regeneration and repair
(Thesis) Main arguer
 David Braga Malta (Master)
2007/07/20 Ex-vivo expansion of hematopoietic stem/progenitor cells: optimization of a human stromal-based co-culture system
(Thesis) Main arguer
 Francisco dos Santos (Master)
2007/07/20 Ex-vivo expansion of human mesenchymal stem cells in three dimensional culture systems
(Thesis) Main arguer
 Pedro Zacarias Andrade (Master)

Association member

Society Organization name Role
2015 - Current EUROSPINE, European Spine Society
2011 - Current TERMIS, Tissue Engineering and Regenerative Medicine Society
2008 - Current ESB, European Society for Biomaterials
2006 - Current SPCE-TC, Portuguese Society of Stem Cells and Cellular Therapy
2015 - 2018 Young Scientists Forum (YSF) of the European Society of Biomaterials Portuguese Chapter

Committee member

Activity description
Role 		Institution / Organization
2021/09/05 - 2021/09/21 Organizing Committee of the 31st Annual Conference of the European Society for Biomaterials (ESB 2021)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/01 - Current Engenharia Regenerativa Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/02/01 - Current Nanotecnologia em Saúde Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/02 - Current Dispositivos Médicos Medicina (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/09/15 - Current Investigação em Neurociências Clínicas, Psiconeuroimunologia Programa Doutoral de Neurociências (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2012/09/15 - Current Nanotecnologia em Saude, Engenharia Celular, Medicina Regenerativa Mestrado Integrado em Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/09/01 - 2022/02/28 Engenharia Celular e Biologia de Células Estaminais Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2016/02/01 - Current Reviewer of PhD and PostDoc fellowships
Evaluator
 Irish Research Council, Ireland
2015/01/01 - Current Reviewer, National Science Centre, Poland
Evaluator

Journal scientific committee

Journal title (ISSN) Publisher
2012/01/01 - Current The Spine Journal (1529-9430) Elsevier
2012/01/01 - Current European Cells and Materials (1473-2262) ECM Research Journal
2009/01/01 - Current PLoS ONE (1932-6203) Public Library of Science
2008/01/01 - Current Biomaterials (0142-9612) Elsevier
2008/01/01 - Current Acta Biomaterialia (1742-7061) Elsevier
2008/01/01 - Current Transplantation Journal (0041-1337) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2008/01/01 - Current Journal of Materials Science Materials in Medicine (1573-4838) Springer-Verlag
2008/01/01 - Current Expert Opinion on Therapeutic Targets (1744-7631) Informa UK (Taylor & Francis)
Distinctions

Award

2021 Amyris Innovation BIG Impact Award to FETALIX
2021 Grammer / European Spine Journal award for the manuscript “Terminal complement complex formation is associated with intervertebral disc degeneration”
2021 Best Oral Communication to F. Castro “Chitosan/Gamma-polyglutamic acid nanoparticles synergize with IFN-gamma to fight breast cancer, 3º encontro nacional de jovens investigadores em oncologia, Liga Portuguesa contra o Cancro
2020 EIT Jumpstarter 2020, category Health, to FETALIX, a spin-of company
2020 Best Poster Award to Castro F et al. “Chitosan/gamma-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer”, Web Conference “Cancer Biology: from basic to Translational Research”, Portuguese Cancer Ligue
2019 Best Oral Presentation for Castro F et al., "Harnessing chitosan and poly(y-glutamic acid) nanoparticles to reprogram the breast tumor microenvironment", 30th European Society for Biomaterials Meeting
2019 Best Oral Presentation for Teixeira G. et al, “Is the terminal complement complex a possible target for therapeutic intervention in intervertebral disc degeneration" at the ISSLS meeting
2018 Georg Schmol Award, German Spine Society "Saggese T et al, Combined inflammatory and mechanical stress weakens the annulus fibrosus: evidences from a loaded bovine AF organ culture” (Eur Spine J)
2018 3rd Place, Best Research Article Award, Tissue Engineering Journal Teixeira et al, A Degenerative/Proinflammatory Intervertebral Disc Organ culture: an ex vivo model for anti-inflammatory drug and cell therapy, Tissue Eng,Part C, 2016
2018 Best Poster Award "Ferreira JR, et al, A ROLE FOR MSCS SECRETOME TO MODULATE THE INFLAMMATORY RESPONSE IN DISC DEGENERATION”, 1st International Symposium “Secretome without borders”, Braga, Portugal
2016 Best Poster, "Pereira CL, et al, Mesenchymal Stem migration in the intervertebral disc, Advanced Summer School, The Nano / Medicine Interface
2016 Best Poster Award, Ferreira JR, et al, The role of MSCs secretome in the degenerated IVD, 7th Symposium in Bioengineering, NEB/FEUP-ICBAS, Porto
2015 5th European Young Researcher Award of CL Pereira (student supervision)
2015 Best Poster Award, "Leite Pereira C et al, MSCs migration in the IVD: a new route for regeneration through the activation of endogenous cells and increased matrix production" Advanced Summer School in Biointerfaces: The Nano/Medicine interface
2013 Best Poster Award, Pereira CL et al, “Mesenchymal Stem Cells Recruitment by SDF-1 delivery in a degenerating Intervertebral Disc”, 2nd Symposium in Applied Bioimaging, Porto, Portugal
2011 Best Poster Award, Galante J et al, Development of Notch signaling biomaterials as a tool to control cell behavior,Interrogations at the Biointerface: The cancer/regeneration interface” Advanced Summer School, Porto
2008 Best Poster Award, Goncalves R et al, Development of Nanostructured Surfaces to Induce Apoptosis of Leukemic Cells, 9th Advanced Summer Course in Cell-Material Interactions

Other distinction

2019 Invited Speaker at TERMIS European Chapter Meeting 2019, Rhodes, Greece
2019 Invited Speaker at EUROSPINE BASIC COMPREHENSIVE COURSE, Lisboa Portugal
2018 Invited Speaker at 1st Symposium in Secretome without borders, Braga Portugal
2018 Invited Speaker at Biomaterials Summer School: Biomaterials for Medical Devices and Regenerative Medicine, Bordeaux, France
2018 Invited Speaker at eCM XVIII conference series: Cartilage & Disc: Repair and Regeneration, Davos, Switzerland
2018 Invited Speaker at AOSpine Masters Symposium - Controversies in the management of degenerative spine disorders, Porto, Portugal
2017 Alexander Humboldt Research Fellowship for Experienced Researchers
2017 Invited Speaker at "IV Symposium of the Portuguese Society of Spine Pathology"
2015 Invited Speaker at Advanced Summer School, Interrogations at the Biointerface: the Nano/Medicine Interface,