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Ana M. Tomás is an Associate Professor in Parasitology at Instituto de Ciências Biomédicas Abel Salazar, University of Porto (ICBAS-UP) and the leader of the Molecular Parasitology Group at Instituto de Investigação e Inovação em Saúde (i3S) in Portugal. She earned her MSc (in Medical Parasitology, 1988) and PhD (in Molecular Parasitology, 1995) from the London School of Hygiene and Tropical Medicine (LSHTM), University of London. She then carried out post -doctoral studies (1995-97) at the Malaria laboratory of the University of Leiden NL, before returning to Portugal in 1998 to initiate her academic career. She is an expert in protozoology her experience extending to several protozoan pathogens (e.g Trypanosoma cruzi, Plasmodium, Leishmania). Ana Tomás scientific interests concern the mechanisms of parasite adaptation and subsistence in their hosts. She expects her studies to impact research on intracellular parasitism and other areas of knowledge and, ultimately, to be exploited for therapy. Resorting to a multidisciplinary approach that combines molecular, cell biology and biochemistry methodologies with in vitro and in vivo models of infection, her group made decisive contributes towards the dissection of the antioxidant mechanisms of Leishmania (most recently, Redox Biology, 2024), a unique and sophisticated network of enzymes that protect parasites from oxidants - including those host-and drug-derived. She described a novel, stress-activated mechanism of Leishmania virulence crucial for parasites to successfully transit from their insect to mammalian hosts (PLoS Pathogens, 2011; PNAS, 2015; Nature Communication, 2019), a major achievement of the group with impacts well beyond the parasitology field. The group interests extend to aspects of Leishmania mitochondrial metabolism (PNAS, 2021) and mechanisms of nutritional virulence (Mol. Microbiology, 2015). ATomás has been PI of different projects and participated in many others. She was National Delegate in three EU COST Networks being vice-chair of one (CM1307, Target therapy towards diseases caused by endoparasites), acted as a member of the Scientific Committee of several international meetings and organized different international meetings, as well as a high number of seminars. She supervised, or is supervising, 5 Post-doctoral fellows, 10 PhD, 19 MSc students, some from international universities, and 8 research assistants and is responsible for the Parasitology Course of the University of Porto PhD programme GABBA (http://gabba.up.pt/). She has published over 70 research articles and several book chapters and was invited as a guest of international meetings as prestigious as the Gordon Conferences, EMBO Workshops or The Society for General Microbiology (UK).
Identification

Personal identification

Full name
Ana Maria Luís Ramos Tomás Tomás

Citation names

  • Tomás, Ana
  • Tomas, AM

Author identifiers

Ciência ID
3D18-2DB9-E49B
ORCID iD
0000-0002-0781-9567

Email addresses

  • atomas@ibmc.up.pt (Professional)

Telephones

Telephone
  • 226074956 (Professional)

Addresses

  • Rua Alfredo Allen, 208 | Porto, Portugal, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Parasitology
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences - Tropical Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
1995
Concluded
Molecular Parasitology (Doctor of Philosophy)
London School of Hygiene and Tropical Medicine Faculty of Infectious and Tropical Diseases, United Kingdom
"Functional Analysis of the major cysteine protease of Trypanosoma cruzi" (THESIS/DISSERTATION)
Sem classificação
1988
Concluded
Medical Parasitology (Master)
London School of Hygiene and Tropical Medicine Faculty of Infectious and Tropical Diseases, United Kingdom
"A preliminary search for the gene for Entamoeba histolytica NADPH: flavin oxidoreductase" (THESIS/DISSERTATION)
Sem classificação
1983
Concluded
BIOLOGIA (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Contribuição para o conhecimento da epidemiologia da toxoplasmose humana na região de Lisboa" (THESIS/DISSERTATION)
15
Affiliation

Science

Category
Host institution
Employer
1995 - 1997 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Hogeschool Leiden, Netherlands
1984 - 1987 Research Assistant (Research) Instituto Nacional de Investigação Científica, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2006 - Current Associate Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1997 - 2006 Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Other Careers

Category
Host institution
Employer
1983 - 1984 Professor do ensino básico e secundário (Professor do ensino básico e secundário) Ministério da Educação, Portugal

Positions / Appointments

Category
Host institution
Employer
2012 - Current Leader of the Molecular Parasitology Group at Instituto de Investigação e Inovação em Saúde (i3S) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Others

Category
Host institution
Employer
1997 - 2011 Principal Investigator at Institute of Molecular and Cell Biology (IBMC) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Contract

Designation Funders
2021/03/29 - 2024/03/28 Drug repurposing from cancer therapy to control of infections
PTDC/BIA-MIC/5343/2020
Principal investigator
2019/02/01 - 2022/01/31 Valorisation of Molecules Isolated from Aquatic Portuguese Amphibians
PTDC/BII-BIO/31158/2017
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2019/12/31 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical diseases
PTDC/QEQ-MED/7097/2014
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2019 Structured program on bioengineered therapies for Infectious diseases and tissue regeneration
Norte-01-0145-FEDER-000012
Researcher
Administração Regional de Saúde do Norte IP
Concluded
2014 - 2015 Host-Pathogen Interaction: from pathogen virulence factors to host responses, disease induction and therapeutic control
NORTE-07-0124-FEDER-000002
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010/11/01 - 2014/04/30 Acquisition of iron in Leishmania infantum - which are the players and what is their relevance for pathogenesis?
PTDC/CVT/100090/2008
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2013/11/30 Survey of the Leishmania thiol system for the development of new anti-parasitic formulas
PTDC/BIA-MIC/100910/2008
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 18 - 2011-2012
PEst-OE/SAU/LA0018/2011
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/09/30 Genetics of accelerated acquisition of drug resistance to multiple drugs (ARMD) in malaria parasites: dynamics and fitness studies.
PTDC/BIA-MIC/65861/2006
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/10/15 - 2011/04/14 Vaccine potential of different Leishmania infantum proteins
PTDC/CVT/70275/2006
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/10/01 - 2008/02/29 Effector mechanisms of macrophages against Leishmania infantum - role of reactive oxygen and nitrogen intermediates and of N-hydroxy-L-arginine in in vitro and in vivo
POCI/SAU-IMI/59560/2004
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/07/01 - 2007/12/31 Microtubule inhibitor formulations against zoonotic visceral leishmaniasis
POCI/CVT/56995/2004
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/07/01 - 2007/08/31 ANTI-LEISHMANIAL DRUGS: study the role of novel polyamine derivative compounds for drug therapy and search for target specific SIR2 inhibitors
POCI/SAU-FCF/59837/2004
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1999 - 2001 Leishmania infantum mitochondrial peroxiredoxin: analysis of its role in parasite protection to oxidative stress.
10.13039/501100001871
Principal investigator
Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2014 - 2018 Targeted chemotherapy towards diseases caused by endoparasites.
COST Action CM1307
Other
Concluded
2013 - 2017 The Network for the Biology of Zinc (Zinc-Net).
COST Action TD1304
Other
Concluded
Outputs

Publications

Book chapter
  1. Castro, H.; Duarte, M.; Tomás, A.M.. "Chapter 16: The Redox Metabolism and Oxidative Stress in Leishmania as a Crossroads for the Lethal Effect of Drugs". In Trypanosomatid Diseases. 2018.
    10.1039/9781788010177-00316
  2. Castro, Helena; Tomás, Ana M.; Castro, H.; Tomás, A.M.; Silva, M.S.; Ferreira, A.E.N.; Gomes, R.; et al. "Thiol Peroxidases of Trypanosomatids". In Trypanosomatid Diseases, 201-213. Wiley-VCH Verlag GmbH & Co. KGaA, 2013.
    Published • 10.1002/9783527670383.ch10
  3. Silva, Marta Sousa; Ferreira, António E. N.; Gomes, Ricardo; Tomás, Ana M.; Freire, Ana Ponces; Cordeiro, Carlos. "Glyoxalase Enzymes in Trypanosomatids". In Trypanosomatid Diseases, 153-166. Wiley-VCH Verlag GmbH & Co. KGaA, 2013.
    10.1002/9783527670383.ch8
  4. Tomas, AM. "Biologia do Parasita". In Leishmaniose canina. Portugal: Chaves Ferreira - Publicações, S.A., 2008.
    Published
  5. Tomas, AM. "Leishmanioses". In A Ciência e o Futuro da Saúde: Doenças Infecciosas e Genéticas. Lisboa, Portugal: Ciência Viva Ed, 2002.
Conference paper
  1. Carvalho, Ricardo Emanuel Silva; Gonçalves, Catarina; Bourbon, Ana Isabel; Pastrana, Lorenzo; Parpot, Pier; Tomás, Ana; Gama, F. M.. "Hyaluronic acid-amphotericin B nanocomplexesa: a promising anti-leishmanial targeted drug delivery system". 2019.
Conference poster
  1. Leão, Teresa; Viegas, Idálio; Trenaman, Anna; Tinti, Michele; Carvalho, Sandra; Duarte, Margarida; Figueiredo, Luisa M.; Tomás, Ana; Horn, David. Corresponding author: Leão, Teresa. "Zinc-based regulation of the trypanosomatid ZIP transporters.". Paper presented in British Society for Parasitology Spring Meeting 2023, 2023.
  2. Smith, Jeff; Vitthal, Sanjay; McGowen, James M.; Dusterhoft, Ron. "How do Leishmania parasites, the agents of the leishmaniases, counteract zinc nutritional immunity?". Paper presented in Cell Biology of Metals Gordon Research Conference, 2019.
    10.2118/58767-ms
  3. Tomas, AM. "Unraveling the zinc acquisition / homeostatic machinery of the human parasite Leishmania". Paper presented in Microbiology Society Annual Conference 2018, 2018.
  4. Leão, Teresa; Carvalho, Sandra; Backx, Elyne; Cruz, Tânia; Castro, Helena; Duarte, Margarida; Tomas, AM. "The ZIP3 and CDF1 transporters, two proteins that allow Leishmania parasites to acquire zinc in a highly regulated way". Paper presented in Zinc-Net/Zinc-UK Meeting, 2016.
  5. Cruz, Tânia; Passos, Joana; Lima, Nuno; Castro, Helena; Cannone-Hergaux, François; Pinto, Jorge; Tomas, AM. "Impact of Leishmania infantum on macrophage iron metabolism proteins". Paper presented in Worldleish 5 | Fifth World Congress on Leishmaniasis, 2013.
  6. Tomas, AM; Jakob, Ursula; Southworth, Daniel R.; Castro, Helena; Teixeira, Filipa. "Leishmania infantum Peroxiredoxin - A Temperature-Regulated Chaperone". Paper presented in FASEB Science Research Conferences. Protein Folding in the Cell. Saxtons River, Vermont, USA, 2012.
  7. Tomas, AM. "Functional characterization of the trypanothione biosynthetic pathway in Leishmania infantum". Paper presented in 3rd I3S Scientific Retreat. 10-11 Maio 2012, Póvoa do Varzim, Portugal., 2012.
  8. Leal, O.; Ferro, L.; Marques, M.; Romão, S.; Cruz, T.; Tomas, AM; Castro, H.; Quelhas, P.. "Automatic assessment of Leishmania infection indexes on in vitro macrophage cell cultures". Paper presented in 3rd I3S Scientific Retreat, 2012.
  9. Carvalho, S.; da Silva, R.; Shakwi, A.; Mackenzie, B.; Eide, D.; Castro, H.; Costa, V.; Tomas, AM. "Leishmania infantum ZIP3 is a zinc transporter that is tightly regulated by zinc status". Paper presented in Experimental Biology San Diego, 2012.
  10. Cruz, T.; Carvalho, S.; Teixeira, F.; Castro, H.; Cannone-Hergaux, F.; Pinto, A.; Tomas, AM. "Leishmania infantum infection modulates the expression of different macrophage iron metabolism proteins". Paper presented in International BioIron Society Annual Meeting, Vancouver, Canada, 2011.
  11. Gaspar, MM.; Castro, H.; Pereira, J.; Tomas, AM; Cruz, MEM. "Antiparasitic effect of stearlyamine cationic liposomes". Paper presented in Medicinal Chemistry in Parasitology. COST CM0801 Annual Meeting. 5-7 Oct, 2011. Modena, Itália., 2011.
  12. Gaspar, MM.; Castro, H.; Pereira, J.; Eleutério, CV; Tomas, AM; Cruz, MEM. "Paromomycin nanoformulations with improved antileishmanial properties". Paper presented in New Indigo Workshop: Antiparasitic and Antitumor drugs. 8-9 Sept 2011, Porto, Portugal, 2011.
  13. Sousa, A.; Jaeger, T.; Flohé, L.; Tomas, AM; Castro, H.. "Functional characterization of the trypanothione biosynthetic pathway in Leishmania infantum". Paper presented in Kinetoplastid Molecular Cell Biology Meeting. 8-12 April 2011, Woods Hole, EUA., 2011.
  14. Castro, H.; Romão, S.; Teixeira, F.; Carvalho, F.; Tomas, AM. "Tryparedoxin-dependent systems: peculiarities and interest for new anti-Leishmania therapies". Paper presented in I3S Scientific Retreat, 6-7 May 2010, Póvoa do Varzim, Portugal., 2010.
  15. Gaspar, MM.; Castro, H.; Tomas, AM; Cruz, MEM. "Paromomycin nanoformulations for treatment of Visceral Leishmaniasis". Paper presented in 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 8-11 March 2010, Valletta, Malta., 2010.
  16. Afonso, A.; Neto, Z.; Castro, H.; Tomas, AM; Do Rosário, V.. "Studies on accelerated resistance to multiple drug (ARMD) in different Plasmodium chabaudi clones with atovaquone and amodiaquine". Paper presented in . The British Society for Parasitology Spring Meeting, 6-8 April 2009, Edinburgh, Scotland., 2009.
  17. Jaeger, T.; Castro, H.; Comini, MA.; Heller, K.; Koch, O.; Schinzer, D.; Stuhlmann, F.; Tomas, AM; Flohé, L.. "Paullones as new drugs for trypanosomatids". Paper presented in Keystone Symposium on “Drug Discovery for Protozoan Parasites”, 22-26 March 2009, Breckenridge, USA., 2009.
  18. Castro, H.; Romão, S.; Irigoin, F.; Radi, R.; Tomas, AM; Romao, S.. "Consequences of mitochondrial peroxiredoxin abrogation in Leishmania infantum infectivity: is the enzyme related to apoptosis regulation?". Paper presented in ? Society for Free Radical Biology and Medicine 14th Annual Meeting, 14-18 November 2007, Washington DC,USA., 2007.
  19. Romão, S.; Castro, H.; Piacenza, L.; Alvarez, MN.; Trujillo, M.; Radi, R.; Tomas, AM; et al. "Peroxynitrite detoxification by Leishmania infantum tryparedoxin peroxidases: implications for parasite infectivity". Paper presented in . The Society for Free Radical Research-Europe 2007 Meeting, 10-13 October, Vilamoura, Portugal., 2007.
  20. Castro, H.; Romao, S.; Tomas, AM. "Abrogation of Leishmania infantum mitochondrial peroxiredoxin impairs parasite infectivity. Function(s) for this enzyme?". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 23-26 April 2007, Woods Hole, USA., 2007.
  21. Romão, S.; Castro, H.; Tomas, AM. "The tryparedoxin and tryparedoxin peroxidases of Leishmania infantum: are they really essential to amastigotes?". Paper presented in 3rd COST-B22 Annual Congress on “Drug discovery and development for parasitic diseases”, 1-4 October 2006, Athens, Greece., 2006.
  22. Castro, H.; Romão, S.; Sousa, C.; Trujillo, M.; Radi, R.; Tomas, AM. "Leishmania infantum mitochondrial peroxiredoxin is not essential for parasite surviva". Paper presented in 11th International Congress on Parasitology, 6th to 11th August, Glasgow, Scotland, UK., 2006.
  23. Romão, S.; Amorim, C.; Castro, H.; Sousa, C.; Carvalho, S.; Tomas, AM. "The Several Tryparedoxin Sequences of Leishmania infantum: Is the cytosolic TXN really a drug target?". Paper presented in 11th International Congress on Parasitology, 6th to 11th August, Glasgow, Scotland, UK, 2006.
  24. Santarem, N.; Carvalho, S.; Romão, R.; Cordeiro-Da-Silva, A.; Costa, V.; Tomas, AM; Santarém, N.; et al. "Iron acquisition in Leishmania amastigotes". Paper presented in 11th International Congress on Parasitology, 6th to 11th August, Glasgow, Scotland, UK., 2006.
  25. Romão, S.; Amorim, C.; Castro, H.; Sousa, C.; Carvalho, S.; Tomas, AM; Romao, S.. "The Tryparedoxin Sequences of Leishmania infantum". Paper presented in ISOP and IWOP-9 joint meeting, June 20-24, Lisbon, Portugal., 2006.
  26. Castro, H.; Romão, S.; Sousa, C.; Tomas, AM. "Tryparedoxins and Tryparedoxin-peroxidases of Leishmania infantum". Paper presented in 9th Iberian Congress of Parasitology, October, 25-28., 2005.
  27. Castro, H.; Sousa, C.; Novais, M.; Santos, M.; Santarem, N.; Cordeiro-Da-Silva, A.; Tomas, AM. "Two distinct hydroperoxide detoxification systems coexist in Leishmania infantum". Paper presented in 1st Luso-Spanish Congress on Free Radicals, Dez, 4-6, Coimbra, Portugal., 2003.
  28. Santarem, N.; Ouaissi, A.; Tomas, AM; Cardoso, L.; Rodrigues, M.; Cordeiro-Da-Silva, A.. "Use of recombinant Leishmania protein antigens to monitor visceral leishmaniasis in dogs". Paper presented in XXIX Annual Meeting of the Portuguese Society for Immunology, Oct. 9-11., 2003.
  29. Cordeiro-Da-Silva, A.; Ferraz, C.; Cardoso, L.; Rodrigues, M.; Castro, H.; Tomas, AM; Cabral, M.; Ouaissi, A.. "Antibodies produced during Leishmania infantum natural infection recognise natural and exogenous antigens". Paper presented in ”. British Society for Parasitology Trypanosomiasis and Leishmaniasis Seminar, Set. 8-11, Edinburgh, Scotland, 2002.
  30. Tavares, Joana; Santos, M.L; Araújo, Natália; Lin, Paul; Castro, Helena; Tomás, Ana; Cordeiro-da-Silva, Anabela. "Trypanothione: a target to polyamines derivatives compounds in Leishmania infantum.". Paper presented in XIII Congresso Nacional de Bioquímica, 2002.
  31. Castro, H.; Lopes, RB.; Cordeiro-Da-Silva, A.; Flohé, L.; Tomas, AM. "Functional characterization of a putative mitochondrial peroxiredoxin from Leishmania infantum". Paper presented in ”. 2nd International Meeting on Cellular Responses to Oxidative and Osmotic Stress, Nov. 7-10, Póvoa de Varzim, Portugal., 2001.
  32. Castro, H.; Lopes, RB.; Cordeiro-Da-Silva, A.; Tomas, AM; cordeiro-da-silva, a. "The mitochondrial H2O2 detoxification system of Leishmania infantum". Paper presented in 4th COST-B9 Congress on Antiprotozoal Chemotherapy, Maio 6-9, Lisboa, Portugal, 2001.
  33. Castro, H.; Cordeiro-da-Silva, A.; Tomas, AM. "A mitochondrial peroxiredoxin from Leishmania infantum: analysis of its role in parasite protection to oxidants". Paper presented in XI Molecular Parasitology Meeting, Set. 17-21, Woods Hole, USA, 2000.
Journal article
  1. Helena Castro; Maria Inês Rocha; Margarida Duarte; Jordi Vilurbina; Ana Georgina Gomes-Alves; Teresa Leao; Filipa Dias; et al. "The cytosolic hyperoxidation-sensitive and -robust Leishmania peroxiredoxins cPRX1 and cPRX2 are both dispensable for parasite infectivity". Redox Biology (2024): https://doi.org/10.1016/j.redox.2024.103122.
    10.1016/j.redox.2024.103122
  2. Silva, Carlos F. M.; Leão, Teresa; Dias, Filipa; Tomás, Ana M.; Pinto, Diana C. G. A.; Oliveira, Eduardo F. T.; Oliveira, Ana; Fernandes, Pedro A.; Silva, Artur M. S.. "Structure–Activity Relationship Studies of 9-Alkylamino-1,2,3,4-tetrahydroacridines against Leishmania (Leishmania) infantum Promastigotes". Pharmaceutics 15 2 (2023): 669. http://dx.doi.org/10.3390/pharmaceutics15020669.
    10.3390/pharmaceutics15020669
  3. Ricardo Silva-Carvalho; Teresa Leão; Francisco M. Gama; Ana M. Tomás; Carvalho, Ricardo Emanuel Silva; Leão, Teresa; Gama, F. M.; Tomás, Ana M.. "Covalent Conjugation of Amphotericin B to Hyaluronic Acid: An Injectable Water-Soluble Conjugate with Reduced Toxicity and Anti-Leishmanial Potential". Biomacromolecules (2022): https://doi.org/10.1021/acs.biomac.1c01451.
    10.1021/acs.biomac.1c01451
  4. "Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I". Proceedings of the National Academy of Sciences 118 42 (2021): e2103803118-e2103803118. http://dx.doi.org/10.1073/pnas.2103803118.
    10.1073/pnas.2103803118
  5. Duarte, Margarida; Ferreira, Cleide; Khandpur, Gurleen Kaur; Flohr, Tamara; Zimmermann, Jannik; Castro, Helena; Herrmann, Johannes M.; Morgan, Bruce; Tomás, Ana M.. "Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I". Proceedings of the National Academy of Sciences 118 42 (2021): http://dx.doi.org/10.1073/pnas.2103803118.
    10.1073/pnas.2103803118
  6. Ana Georgina Gomes-Alves; Margarida Duarte; Tânia Cruz; Helena Castro; Francisca Lopes; Rui Moreira; Ana S. Ressurreição; Ana M. Tomás. "Biological Evaluation and Mechanistic Studies of Quinolin-(1 H )-Imines as a New Chemotype against Leishmaniasis". Antimicrobial Agents and Chemotherapy 65 7 (2021): https://doi.org/10.1128/AAC.01513-20.
    10.1128/AAC.01513-20
  7. Tomas, AM. "Epigallocathechin-O-3-gallate inhibits trypanothione reductase of Leishmania infantum, causing alterations in redox balance and leading to parasite death". Front. Cell. Infect. Microbiol. (2021):
    Open access • Accepted
  8. Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria Silva; et al. "Mechanistic insights into the leishmanicidal and bactericidal activities of Batroxicidin, a Cathelicidin-related peptide from a South American viper (Bothrops atrox)". Journal of Natural Products 84 6 (2021): 1787-1798. http://hdl.handle.net/10451/49604.
    10.1021/acs.jnatprod.1c00153
  9. Alves, Ana G. Gomes; Duarte, Margarida; Cruz, Tânia; Castro, Helena; Lopes, Francisca; Moreira, Rui; Ressurreição, Ana S.; Tomás, Ana M.. "Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evaluation and mechanistic studies". (2021): http://hdl.handle.net/1822/75760.
    10.1128/AAC.01513-20
  10. Silva-Carvalho, R.; Fidalgo, J.; Melo, K.R.; Queiroz, M.F.; Leal, S.; Rocha, H.A.; Cruz, T.; et al. "Development of dextrin-amphotericin B formulations for the treatment of Leishmaniasis". International Journal of Biological Macromolecules 153 (2020): 276-288. http://dx.doi.org/10.1016/j.ijbiomac.2020.03.019.
    10.1016/j.ijbiomac.2020.03.019
  11. Rocha, Maria Inês; Dias, Filipa; Resende, Mariana; Sousa, Mafalda; Duarte, Margarida; Tomás, Ana Maria; Castro, Helena. "Leishmania infantum Enhances Migration of Macrophages via a Phosphoinositide 3-Kinase ¿-Dependent Pathway". ACS Infectious Diseases 6 7 (2020): 1643-1649. http://dx.doi.org/10.1021/acsinfecdis.0c00080.
    10.1021/acsinfecdis.0c00080
  12. Castro, Helena; Cruz, Tânia; de Aguiar Amaral, Patrícia; da Silva Cardoso, Paula; Alsaffar, Ahmed; Farrell, Patrick; Tomás, Ana M.; Barlow, James W.. "Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents". Heliyon 6 3 (2020): e03614-1-11. http://dx.doi.org/10.1016/j.heliyon.2020.e03614.
    Open access • Published • 10.1016/j.heliyon.2020.e03614
  13. Castro, Helena; Rocha, Maria Inês; Silva, Ricardo; Oliveira, Filipe; Gomes-Alves, Ana Georgina; Cruz, Tânia; Duarte, Margarida; Tomás, Ana Maria. "Functional insight into the glycosomal peroxiredoxin of Leishmania". Acta Tropica 201 (2020): 105217. http://dx.doi.org/10.1016/j.actatropica.2019.105217.
    10.1016/j.actatropica.2019.105217
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  71. Castro, H.; Sousa, C.; Santos, M.; Cordeiro-da-Silva, A.; Flohé, L.; Tomás, A.M.. "Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum". Free Radical Biology and Medicine 33 11 (2002): 1552-1562. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036889825&partnerID=MN8TOARS.
    10.1016/S0891-5849(02)01089-4
  72. Tomas, A.M.; Margos, G.; Dimopoulos, G.; Van Lin, L.H.M.; De Koning-Ward, T.F.; Sinha, R.; Lupetti, P.; et al. "P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions". EMBO Journal 20 15 (2001): 3975-3983. http://www.scopus.com/inward/record.url?eid=2-s2.0-17844382946&partnerID=MN8TOARS.
    10.1093/emboj/20.15.3975
  73. Tomas, A.M.; Van der Wel, A.M.; Thomas, A.W.; Janse, C.J.; Waters, A.P.. "Erratum: Transfection systems for animal models of malaria (Parasitology Today (1998) 14 (245-249))". Parasitology Today 14 8 (1998): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031819835&partnerID=MN8TOARS.
  74. Matos, O.; Tomás, A.; Aguiar, P.; Casemore, D.; Antunes, F.. "Prevalence of cryptosporidiosis in AIDS patients with diarrhoea in Santa Maria Hospital, Lisbon". Folia Parasitologica 45 2 (1998): 163-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031851678&partnerID=MN8TOARS.
  75. Tomas, A.M.; Van Der Wel, A.M.; Thomas, A.W.; Janse, C.J.; Waters, A.P.. "Transfection systems for animal models of malaria". Parasitology Today 14 6 (1998): 245-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031815876&partnerID=MN8TOARS.
    10.1016/S0169-4758(98)01248-4
  76. Tomas, A.M.; Miles, M.A.; Kelly, J.M.. "Overexpression of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, is associated with enhanced metacyclogenesis". European Journal of Biochemistry 244 2 (1997): 596-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031047603&partnerID=MN8TOARS.
  77. Van Der Wel, A.M.; Tomás, A.M.; Kocken, C.H.M.; Malhotra, P.; Janse, C.J.; Waters, A.P.; Thomas, A.W.. "Transfection of the primate malaria parasite Plasmodium knowlesi using entirely heterologous constructs". Journal of Experimental Medicine 185 8 (1997): 1499-1503. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031002513&partnerID=MN8TOARS.
    10.1084/jem.185.8.1499
  78. Tomás, A.M.; Kelly, J.M.. "Stage-regulated expression of cruzipain, the major cysteine protease of Trypanosoma cruzi is independent of the level of RNA". Molecular and Biochemical Parasitology 76 1-2 (1996): 91-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029978872&partnerID=MN8TOARS.
    10.1016/0166-6851(95)02545-6
  79. Tomas, A.M.; Kelly, J.M.. "Transformation as an approach to functional analysis of the major cysteine protease of Trypanosoma cruzi". Biochemical Society Transactions 22 2 (1994): http://www.scopus.com/inward/record.url?eid=2-s2.0-0028340895&partnerID=MN8TOARS.
  80. Kelly, J.M.; Das, P.; Tomás, A.M.. "An approach to functional complementation by introduction of large DNA fragments into Trypanosoma cruzi and Leishmania donovani using a cosmid shuttle vector". Molecular and Biochemical Parasitology 65 1 (1994): 51-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027998830&partnerID=MN8TOARS.
    10.1016/0166-6851(94)90114-7
  81. Tomas, AM. "Cryptosporidium e criptosporidiose: conceitos actuais e importância em patologia humana.". Jornal do Médico CXX (1986): 5-8.
Thesis / Dissertation
  1. Fidalgo, João Miguel Pereira. "Development of a water-soluble Dextrin-Amphotericin B formulation for the treatment of Leishmaniasis". Master, 2018. https://hdl.handle.net/1822/60464.
  2. Fidalgo, João Miguel Pereira. "Development of a water-soluble Dextrin-Amphotericin B formulation for the treatment of Leishmaniasis". Master, 2018. https://hdl.handle.net/1822/60464.

Other

Other output
  1. Corrigendum to “Development of dextrin-amphotericin B formulations for the treatment of Leishmaniasis” [Int. J. Biol. Macromol., 15 (2020) 276–288](S0141813019404066)(10.1016/j.ijbiomac.2020.03.019). The authors regret to inform that there are some inaccuracies in the above referred article. More specifically, in the end of the Results and Discussion section 3.6. Anti-Leishmania activity against axenic promastigote and intramacrophagic L. infantum amastigotes it is described the following “Dex-AmB nanocomplexes had an activity similar to the free-drug, despite the slightly higher IC50 values -. 2021. Carvalho, Ricardo Emanuel Silva; Fidalgo, J.; Melo, K. R.; Queiroz, M. F.; Leal, Ana Salomé Barbosa; Rocha, H. A.; Cruz, T.; et al. http://hdl.handle.net/1822/68756.
    10.1016/j.ijbiomac.2020.07.193
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/10/10 The exotic redox metabolism of trypanosomatids: state of play after 35 years of research EMBO Workshop - Thiol oxidation in biology: Biochemical mechanisms to physiological outcomes
EMBO (Sant Feliu de Guixols)
2022/10 Revisiting the Antioxidant Systems of Leishmania 3rd International Caparica Conference on Leishmaniasis 2022
(Caparica, Portugal)
2022/08/23 The Antioxidant systems of Leishmania and their role in parasite infectivity: a tale of fascinating enzymes XXXVII Annual Meeting of the Brazilian Society of Protozoology XLVIII Annual Meeting on basic research in Chagas´Disease
SBPZ - Brazilian Society of Protozoology (Caxambu, Brazil)
2018 Unraveling the zinc acquisition/homeostatic machinery of the human parasite Leishmania infantum Microbiology Society Annual Conference
Microbiology Society (Birmingham, United Kingdom)
2017 Invited speaker - 4º Congresso Nacional de Medicina Tropical
Insituto de Higiene e Medicina Tropical (Lisboa, Portugal)
2017 ZIP3 and CDF1, two transporters that allow Leishmania parasites to acquire zinc in a highly regulated way 6th i3S Annual Meeting
(Póvoa do Varzim, Portugal)
2017 Functional analysis of the inducible zinc transporter LiZIP3 in Leishmania infantum - A CRISPR-Cas9 based approach IJUP'17 - 10º Encontro de Jovens Investigadores da Universidade do Porto
(Porto, Portugal)
2016 Society of General Microbiology Annual Conference
(Liverpool, United Kingdom)
2016 Invited speaker - Iron and zinc in infections by Leishmania Society for General Microbiology Annual Conference. Liverpool, UK
2015 Centro de Neurociências e Biologia Celular
Universidade de Coimbra (Cantanhede, Portugal)
2015 1º Congresso Doenças Negligenciadas e Reemergentes
(Parnaíba, Brazil)
2015 Invited speaker - Factores Determinantes na Infecção por Leishmania 3º Congresso Nacional de Medicina Tropical, Institute of Hygiene and Tropical Medicine, Lisbon, Portugal
2015 Invited speaker - Biologia Molecular e infecção por Leishmania
1º Congresso Doenças Negligenciadas e Reemergentes, Pernaíba, Brazil
2014 Gordon Research Conference Thiol-Based Redox Regulation & Signaling
(Girona, Spain)
2014 31th Annual Swiss Trypanosomatid Meeting
(Leysin, Switzerland)
2014 Invited speaker - Reduced Decameric Leishmania Peroxiredoxin mTXNP is a Temperature-Regulated Bona Fide Chaperone Talk Gordon Research Conference Thiol-Based Redox Regulation & Signaling, Girona, Spain
2014 Invited speaker - The Leishmania infantum mitochondrial tryparedoxin peroxidase:a chaperone essential for parasite infectivity 31th Annual Swiss Trypanosomatid Meeting, Leysin, Switzerland
2014 Invited speaker - A peroxidase that turns into a chaperone: the story of a protein essential for Leishmania infectivity Institute for Molecular Medicine (IMM), Lisbon, Portugal
2013 The ZIP3 protein of Leishmania infantum - a zinc importer tightly regulated by zinc status WorldLeish 5
(Porto de Galinhas, Brazil)
2013 The Leishmania infantum tryparedoxin peroxidase – A temperature-regulated chaperone essential to parasite infectivity? WorldLeish 5
(Porto de Galinhas, Brazil)
2013 Validation of trypanothione synthetase as a drug target in the glutathionylspermidine synthase-containing parasite Leishmania infantum WorldLeish 5
2013 Zoonotic visceral leishmaniosis - new insights in the dynamics of cellular memory WorldLeish 5
2012 The Leishmania infantum mitochondrial antioxidant system and its role in parasite infectivity Institute of Molecular and Cell Biology "Friday Noon Seminar"
(Porto, Portugal)
2012 Automatic assessment of Leishmania infection indexes on in vitro macrophage cell cultures 4th Annual Meeting COST Action CM0801. Crete, Greece.
2012 Leishmania infantum ZIP3 is a zinc transporter that is tightly regulated by zinc status I3S Scientific Retreat. Póvoa de Varzim, Portugal
2011 Functional Characterization of the Trypanothione Biosynthetic Pathway of Leishmania infantum. New Drugs for Neglected Diseases. Medicinal Chemistry in Parasitology COST CM0801 Annual Meeting, Modena, Itália
2011 Leishmania Mitochondrial Peroxiredoxin Plays a Crucial Peroxidase-Unrelated Role during Infection. New Drugs for Neglected Diseases. Medicinal Chemistry in Parasitology COST CM0801 Annual Meeting. Modena, Itália
2011 Investigation of 1,3,4-thiadiazolium-2-amidine derivatives activity in Leishmania spp. and trypanothione reductase. New Drugs for Neglected Diseases. Medicinal Chemistry in Parasitology COST CM0801 Annual Meeting. Modena, Itália.
2011 Improved antileishmanial performance of paromomycin through association to liposomes Third annual meeting of COST Action BM0802: Life or Death of Protozoan Parasites, Brussels, Belgium.
2010 Invited speaker - Genetic transformation of parasites. Seminars integrated in the IHMT/Rides Malaria/Renorbio/ UFPi (CPLP) Post-graduation Course on “Recent Developments in molecular and Cell Biology with an emphasis on Malaria”
Universidade Federal do Piauí (Teresina, Brazil)
2010 . Tryparedoxin-dependent systems: peculiarities and interest for new therapies . 2nd Joint Expert Meeting between Working Groups 1, 2, 3 and 4of the COST Action CM0801, Universitá degli studi di Siena, Siena, Italy
2010 Progress towards the development of the “CellNote” software, a platform for determination of intracellular parasitaemia in Leishmania infected macrophages
2nd Joint Expert Meeting between Working Groups 1, 2, 3 and 4of the COST Action CM0801, Universitá degli studi di Siena, Siena, Italy
2009 CellNote - a platform for determination of intracellular parasitaemia in Leishmania infected macrophages COST CM0801 Expert Meeting, London, UK.
2009 Hydroperoxide metabolism in Leishmania - peculiarities and interest for drug development . 1st Joint Expert Meeting between Working Groups 1 and 3 of the COST Action CM0801, South-West University, Campus Bachinovo, Bulgaria.
2009 Targeting trypanothione synthetase for the development of new drugs against kinetoplastids 1st Joint Expert Meeting between Working Groups 1 and 3 of the COST Action CM0801, South-West University, Campus Bachinovo, Bulgaria.
2009 What does the “classical” tryparedoxin/peroxiredoxin pathway still has to offer to drug design? 10th Drug Design & Development Seminar in Conjunction with the 2nd Management Committee Meeting COST Action CM0801 “New drugs for neglected diseases”, Rauischholzhausen Castle, Germany.
2009 New prospects regarding the classical tryparedoxin/peroxiredoxin pathway operating within the Leishmania infantum mitochondrion 4th World Congress on Leishmaniasis (WL4), Lucknow, India.
2008 Invited speaker - Genetic transformation of parasites. Seminars integrated in the IHMT/Rides Malaria/Renorbio/ UFPi (CPLP) Post-graduation Course on “Recent Developments in molecular and Cell Biology with an emphasis on Malaria”
Universidade Federal do Piauí (Teresina, Brazil)
2008 Leishmania infantum amastigotes can use both heme and non-heme iron sources European Iron Club, Annual Meeting, St. Gallen, Switzerland.
2007 Peroxynitrite detoxification by Leishmania infantum tryparedoxin peroxidases: implications for parasite infectivity Free Radicals in Montevideo 2007, V Meeting of SFRBM - South American Group and V International Conference on Peroxynitrite and Reactive Nitrogen Species, Montevideo, Uruguay.
2005 Iron acquisition in Leishmania infantum amastigotes 9th Iberian Congress of Parasitology
2005 Flow cytometry analysis as na alternative diagnostic method to canine leishmaniasis . Congresso da Sociedade Ibérica de Citometria
2004 Invited speaker - Mechanisms of gene expression and regulation in trypanosomatids. Seminar part of the Howard Hughes International Course "Pathogen Trypanosomes-mammalian host cell interactions: biochemistry, cell biology and prospects for drug development"
Facultad de Medicina de la Universidade de la Republica (Montevideo)
2004 Invited speaker - Malaria in Portugal. Meeting of biologists from the Portuguese speaking countries (CPLP), Lisbon, Portugal
(Lisboa, Portugal)
2004 Invited speaker - Complementary antioxidant defence systems in Leishmania infantum Symposium “Peroxides and parasites”
(Braunschweig, Germany)
2004 Glutathione Peptides as Antiprotozoal Agents: Mode of Action World Conference on Dosing of Anti-infectives – Dosing the Magic Bullets, Nurnberg, Germany.
2002 Invited speaker - The antioxidant system of Leishmania, target for chemotherapy?
Instituto de Higiene e Medicina Tropical (Lisboa, Portugal)
2002 Invited speaker - The process of peroxide detoxification in Leishmania infantum
Centre IRD de Montpellier, Unité Pathogénie des Trypanosomatidés (Montpellier, France)
2002 A mitochondrial peroxiredoxin in Leishmania infantum antioxidant defence British Society for Parasitology Trypanosomiasis and Leishmaniasis Seminar, Edinburgh, Scotland.
2002 Compartmented antioxidant defence by peroxiredoxins in Leishmania infantum 2nd International Symposium on Antioxidants in Nutrition and Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Bali, Indonesia.
2001 Invited speaker - As Leishmanioses, doenças do Homem e do cão
Visionário, Santa Maria da Feira, Portugal
2000 Invited speaker - As Leishmanioses. Ciclo de colóquios “A Ciência e o futuro da Saúde: doenças infecciosas e genéticas”
Pavilhão do Conhecimento (Lisboa, Portugal)
2000 A mitochondrial peroxiredoxin from Leishmania infantum: analysis of its role in parasite protection to oxidative stress ”. XII Congresso Nacional de Bioquímica, Póvoa de Varzim, Portugal.
1999 Invited speaker - Análise, por gene-targeting, de dois antigénios de superfície dos estádios sexuados de Plasmodium: implicações para o desenvolvimento de uma vacina contra a malária VI Fórum Farmacêutico “Novas terapias e tecnologias farmacêuticas”
(Porto, Portugal)
1998 Análise por gene-targeting, de dois antigénios de superfície dos estadios sexuados de Plasmodium: implicações para o desenvolvimento de uma vacina contra a malária 4ª Reunião da Sociedade Portuguesa de Parasitologia. Vila Real, Portugal
1998 The Plasmodium berghei ookinete surface antigen Pbs25 is not essential for parasite transmission XIth European SOVE Meeting, Lisboa, Portugal
1998 Functional redundancy of malarial surface molecules in the mosquito host: implications for vaccine design XIth European SOVE Meeting, Lisboa, Portugal
1990 Toxoplasma antibodies and toxoplasmic encephalitis in HIV-infected people VII International Congress of Parasitology, Paris, France
1988 Serological survey on African Tripanosomiasis in Guinea Bissau (West Africa) ). Jornadas Internacioais de Medicina Tropical, Lisbon, Portugal
1986 Toxoplasmose cerebral num doente com SIDA AIDS Symposium, Lisbon, Portugal
1986 Encefalite toxoplásmica em doentes com SIDA AIDS Conference, Lisbon, Portugal.
1985 Endemcidade da toxoplasmose na região de Lisboa 4th Infectious Disease Meeting, Porto, Portugal.

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/01/01 - Current Micronutrient sensing in human pathogenic parasites
Supervisor
Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - Current Repurposing Anti-Cancer Drugs as Potential Inhibitors for Metastatic Leishmania Infections
Supervisor of Filipa Dias
Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - Current Development of new therapies leishmaniasis using polymeric nanoparticles
Supervisor of Ana Georgina Gomes Alves
2022 - 2023 Characterization of differentially expressed p27 and p28 cytochrome c oxidase subunits in Leishmania infantum and their role in infection
Co-supervisor
Master of Biomedical Sciences: Infectious and Tropical Diseases (Master)
Universiteit Antwerpen, Belgium
2022 - 2023 The impact of Leishmania infection on the migratory behaviour of host macrophages
Supervisor
Mestrado em Microbiologia (Master)
Universidade de Aveiro, Portugal
2020 - 2021 Can AIP56, Apoptosis Inducing Protein of 56kDa, be used as an antigen delivery system for Leishmaniasis
Supervisor of Amber Van Laer
Biomedical Sciences (Master)
2020 - 2021 Exploring the role of Leishmania phylogeny in the migration of their macrophage host
Supervisor
Master in Biomedical Sciences, (Master)
Universiteit Antwerpen, Belgium
2020 - 2021 Exploring the impact of different Leishmania species in the macrophage PI3K pathway
Supervisor
Licenciatura em Bioquímica, ICBAS-UP (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2018 - 2019 Identification of p28 - a differentially expressed subunit of cytochrome c oxidase in Leishmania infantum
Co-supervisor of Mathieu Claes
Biomedical Sciences (Master)
Universiteit Antwerpen Faculteit Farmaceutische Biomedische en Diergeneeskundige Wetenschappen, Belgium
2017 - 2019 Disclosing the zinc acquisition and homeostatic machinery of Leishmania parasites
Supervisor of Teresa Pires de Matos Alves Leão
Natural Sciences (Master)
2017 - 2018 Functional characterization of LiCDF transporter in Leishmania infantum
Supervisor of Tatiana Piller
Biomedical Sciences (Master)
Universiteit Antwerpen Faculteit Farmaceutische Biomedische en Diergeneeskundige Wetenschappen, Belgium
2017 - 2018 AIP56, an AB toxin from the fish pathogenic bacterium Photobacterium damselae subsp. piscicida, as a possible drug and/or antigen delivery system for leishmaniasis.
Supervisor of Laura Dirkx
Biomedical Sciences
Universiteit Antwerpen Faculteit Farmaceutische Biomedische en Diergeneeskundige Wetenschappen, Belgium
2017 - 2018 Leishmania mitochondrial function and disease progression
Co-supervisor of Alexandra Soares Rodrigues
Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2017 Uncovering the mechanism of Ferroportin-1 downmodulation upon Leishmania infantum infection
Co-supervisor of Maria Silva Vieira
Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2017 The impact of Leishmania infection on host cell migration
Co-supervisor of Maria Inês Rocha
Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2012/10/17 - 2016/07/07 Praziquantel-resistance in Schistosoma mansoni: role of efflux pumps, phenotypic characteristics and proteomics analysis
Co-supervisor of António Pinto-Almeida
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 Development of systems to facilitate target identification and drug development in Leishmania infantum
Supervisor of Elyne Backx
Biomedical Sciences (Master)
Universiteit Antwerpen Faculteit Farmaceutische Biomedische en Diergeneeskundige Wetenschappen, Belgium
2015 - 2016 CRISPR-Cas9–mediated ablation and functional analysis of the zinc transporter LiZIP3 in Leishmania infantum
Supervisor of Teresa Pires de Matos Alves Leão
Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2011 - 2015 The mitochondrial peroxiredoxin of Leishmania - a novel member of the parasite chaperone network, crucial for infection
Supervisor of Filipa Daniela Pinheiro Teixeira
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2014 Study of Leishmania infantum zinc transporter:what is its role in zinc homeostasis
Co-supervisor of Matilde Viegas
Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2012 - 2013 Study of the regulation of a zinc transporter in Leishmania infantum
Co-supervisor of Ana Sofia Ramos
Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2013 Contributions for the improved control of Leishmania infantum infection: Roles of Iron, reative oxygen species and aminoquinolines
Co-supervisor of Sílvia Marisa Nogueira do Vale Costa
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2012 Studies on metal acquisition in Leishmania infantum
Supervisor of Sandra Isabel Pereira de Carvalho
Ciências Biomédicas
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - 2012 Iron metabolism in the context of a Leishmania infantum infection
Supervisor of Tânia Carina Bértolo da Cruz
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 - 2011 Thiol-dependent metabolism in the mitochondrium of Leishmania infantum
Co-supervisor of Filipa Daniela Pinheiro Teixeira
^Biologia (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2006 - 2010 Cryptosporidium spp and Giardia duodenalis: protozoa transmitted through water. Detection and genetic characterization - new approaches
Co-supervisor of André Augusto da Silva Almeida
Ciências Veterinárias (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2009 Iron and Infections by Protozoa
Supervisor of João Pedro Madaíl
Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - 2009 The cytosolic hydroperoxide detoxification system of Leishmania infantum.
Supervisor of Susana de Freitas Romão
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001 - 2006 Hydroperoxide metabolism in Leishmania infantum
Supervisor of Helena Maria de Sousa Castro
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2004 - 2005 Investigation on the iron sources for amastigotes of Leishmania infantum
Supervisor of Nuno Pedro Moreira Santarém
Microbiology (Master)
Universidade de Aveiro, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2016 - 2016 Targetting Metabolism and Transport in Parasites: Drugs and delivery systems”. WG1 and WG4 meeting, COST Action 1307 Conference, Porto, Portugal 2016. (2016)
Conference
2009 - 2009 FLAD/NIAID-NIH Conference on Malaria. Lisbon, Portugal. 2009 (2009)
2001 - 2001 Euroconference: 2nd International Meeting on Cellular Responses to Oxidative and Osmotic Stress (IMOOS), Póvoa de Varzim, Portugal. 2001. (2001)

Conference scientific committee

Conference name Conference host
2009 - 2009 FLAD/NIAID-NIH Conference on Malaria FLAD

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013 - Current Parasitology Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal
2002 - Current Biology of Infection Bioquímica (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2002 - Current Pathology Medicina (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000 - Current Parasitology Biologia Básica e Aplicada (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1997 - Current Veterinary Parasitology Medicina Veterinária (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2013 Parasite Chemotherapy Biotechnology, Bioprocessing and Business Management (Master) University of Warwick, United Kingdom

Other jury / evaluation

Activity description Institution / Organization
2021 - 2021 Grant Review - Czech Science Foundation, Czech REpublica
2018 - 2018 Grant review - Medical Research Council, UK, 2018
2016 - 2016 Grant review - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO), Belgium, 2016.
2016 - 2016 Grant review - FINOVI Foundation, France, 2016.
2014 - 2014 Grant review - European Research Foundation (Axa Research Fund), 2014
2014 - 2014 Grant review - European Research Foundation (Axa Research Fund), 2014
2010 - 2010 Grant review - Agence National de Recherche (France), 2010
Distinctions

Award

1984 Prémio Morais David de Doenças Infecciosas
Pfizer Ltd, United Kingdom
1984 UpJohn Infectious Disease Prize

Other distinction

1996 Postdoctoral Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1991 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1987 MSc Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1984 Research Fellowship
Instituto Nacional de Investigação Científica, Portugal