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Ana Rita Grosso gathered a Biology degree (FCUL, 2002), followed by a MSc in Bioinformatics (FCUL-IGC, 2006). Her multi-omics expertise in biomedical research was accomplished by gathering a PhD in Biomedical Sciences (iMM/FMUL, 2010), where she unveiled the existence of splicing-factors expression signatures responsible by the tissue-specific regulation of alternative splicing. During her PostDoc (iMM) she disclosed new mechanisms underlying epigenetics, transcription and splicing dynamics. In 2018, Ana Rita Grosso moved to NOVA School of Science and Technology (FCT-NOVA) and Applied Molecular Biosciences Unit (UCIBIO) to foster her scientific independence and consolidate her research group: Computational Multi-Omics. Her main mission is to decipher pathological conditions using multi-omics approaches, identifying molecular events to be further used as biomarkers and therapeutic targets. Highlighting, she has been unveiling (epi)genome/transcriptome alterations that affects tumor evolution and metastasis development. To date, Ana Rita Grosso published 51 papers and 2 chapter books (enclosing 2401 citations). Also, she won in highly competitive schemes: 4 Salary Grants (PhD and PostDoc Fellowships, 2 Research Contracts); 11 Projects Grants (5 as PI/Co-PI and 7 as Team Member), 1 EMBO Workshop, as well as 3 Pfizer Awards for Basic Research. Finally, she has been fostering advance training in the computational biology field by supervising 4 PostDoc researchers, 4 PhD students, 3 MSc fellows, 10 MSc students, 7 BSc students and several short-term trainees. Additionally, she has been teaching MSc and BSc courses focused on Genomics and Computational Biology fields in FCT-NOVA.
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Identification

Personal identification

Full name
Ana Rita Grosso

Citation names

  • Grosso, Ana Rita

Author identifiers

Ciência ID
3D18-571E-133A
ORCID iD
0000-0001-6974-4209
Researcher Id
I-6656-2013
Scopus Author Id
26639262500

Email addresses

  • argrosso@fct.unl.pt (Professional)

Addresses

  • Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Almada, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010
Concluded
 Ciências Biomedicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"New insights into alternative splicing using microarray technology " (THESIS/DISSERTATION)
 Distinção e Louvor por unanimidade
2006
Concluded
 Bioinformatica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Statistical Methodologies for the Analysis of DNA Microarray Data" (THESIS/DISSERTATION)
 Muito Bom
2002
Concluded
 Biologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"“Estudo Filogenético de Populações Europeias de Columba palumbus (Pombo-Torcaz), Recorrendo à Análise de DNA Mitocondrial”" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2018/01/01 - 2022/03/31 Auxiliary Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015/01/01 - 2017/12/31 Auxiliary Researcher (Research) Instituto de Medicina Molecular, Portugal
2010/03/01 - 2014/12/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2002/10/01 - 2005/12/31 Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/04/01 - Current Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2023/12 - 2026/11 The cell of origin of Pancreatic Cancer: novel opportunities for the early diagnosis and treatment
HR23-00442
 Caixabank SA
2023/03/01 - 2026/02/28 Innovative approaches for pancreatic cancer: Decoding and manipulating immune response to short sialylated O-glycans
2022.04607.PTDC Abordagens inovadoras para cancro pancreático: Descodificando e manipulando a resposta imune a O-glicanos sialilados Innovative appro
Researcher
2023/02/15 - 2026/02/14 Dissecting the molecular mechanisms of X-chromosome inactivation using human embryonic stem cells
2022.01532.PTDC
Co-Principal Investigator (Co-PI)
2023/02/13 - 2026/02/12 NANOHEAT – Gold nanoconjugates for improved photothermal ablation of colorectal cancer
2022.04315.PTDC
Researcher
2022 - 2024 Ovarian Cancer Avatars for personalized therapy, a combination of in vivo & ex-vivo models to guarantee a test for every patient
PTDC/BTM-SAL/3796/2021
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2022 - 2024 Unveiling the signatures of convergent evolution in bee-associated microorganisms: a comparative multi-omics approach
PTDC/BIA-EVL/0604/2021
PTDC/BIA-EVL/0604/2021
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2021 - 2023 Harnessing comparative genomics to understand the role of horizontal acquired genes in the evolution of yeast metabolism
PTDC/BIA-EVL/1100/2020
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2021 - 2023 Unravelling evolutionary physiology landscapes of coastal marine fauna under extreme temperatures using a multi-layer Systems Biology approach
PTDC/BIA-BMA/1494/2020
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2019 - 2022 The Portuguese biotechnological database for marine animal venoms and toxins
MARVEN
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2018/10/01 - 2021/09/30 Targeting Intra-Tumor heterogeneity as a promising therapeutic strategy for cancer
PTDC/MED-ONC/28660/2017
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2018/08/01 - 2021/07/31 A critical role for DNA damage in transcription that impacts cell differentiation and tumor development
PTDC/BIA-MOL/30438/2017
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2015/01/01 - 2019/12/01 Decoding pseudogene transcriptional regulation during cell differentiation
IF/00510/2014
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2016/01 - 2018/12 Novel tumorigenic mechanisms of aberrant epigenetic regulation in clear cell renal cell carcinoma
Provided by PTCRIS: 138597
 Fundação para a Ciência e a Tecnologia, I.P.
2015/12 - 2018/11 Long non-coding RNAs as new diagnostic biomarkers for African Sleeping sickness.
Provided by PTCRIS: 145744
 Fundação para a Ciência e a Tecnologia, I.P.
2013/06 - 2015/11 SETD2 mediates a novel tumor suppressor mechanism that is misregulated in clear cell renal carcinoma
Provided by PTCRIS: 124736
 Fundação para a Ciência e a Tecnologia, I.P.
2011/02 - 2014/01 Splicing-coupled mechanisms of chromatin remodeling and their global role in transcription
Provided by PTCRIS: 111451
 Fundação para a Ciência e a Tecnologia, I.P.
2011/01 - 2013/12 The role of RNA polymerase II in splicing regulation
Provided by PTCRIS: 113440
 Fundação para a Ciência e a Tecnologia, I.P.
2007/09 - 2010/08 Mechanisms of splicing regulation by U2AF proteins
Provided by PTCRIS: 69739
 Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/12/31 - 2025/12/30 Contract "FCT CEEC Individual" - Targeting Intra-Tumor heterogeneity as a promising therapeutic strategy for cancer
CEECIND/02699/2017
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Researcher
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/01/01 - 2019/12/31 Decoding pseudogene transcriptional regulation during cell differentiation
IF/00510/2014
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
Outputs

Publications

Book chapter
  1. Pinto, Rui; Sobral, Daniel; Grosso, Ana Rita. Corresponding author: Grosso, Ana Rita. "Comprehensive Detection of Pseudogenes Transcribed by Readthrough". 85-102. Springer {US, 2021.
    10.1007/978-1-0716-1503-4_6
  2. Grosso, Ana Rita; Carmo-Fonseca, Maria. "The Potential of Targeting Splicing for Cancer Therapy". In Nuclear Signaling Pathways and Targeting Transcription in Cancer, 313-336. Springer New York, 2013.
    Published • 10.1007/978-1-4614-8039-6_13
Conference abstract
  1. Nunes, Miguel; Moutinho Cabral, Inês; Cátia Gonçalves; Fernandes, Joana F.; Missionário, M.; Travesso, M. ; Grosso, Ana Rita; et al. Corresponding author: Nunes, Miguel. "Goby fish populations in intertidal environments: gene networks and epigenetic regulators modulating energy metabolism in response to seasonal warming and local climate regimes.". Paper presented in International Conference for YOUNG Marine Researchers (ICYMARE), Bremerhaven, 2022.
  2. Couceiro, Joana; Grosso, Ana Rita; Baptista, P V; Mendes, J J; Fernandes, A R; Quintas, Alexandre (ORCID: 0000-0002-5188-0453). "The genetic susceptibility linking preterm birth and periodontal disease ¿ a review.". 2021.
    Accepted
  3. Martins, Carla; Rodrigo, Ana P.; Madeira, Carolina; D' Ambrosio, Mariaelena; C. Gonçalves; A. J. Parola; Grosso, Ana Rita; et al. "Porphyrin pigments in polychaeta: explorations on the evolution of haem metabolism in marine eumetazoans". Paper presented in XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products, Peniche, 2020.
    Published
Conference paper
  1. Patricia Abrantes; G. Dimopoulos; Ana Rita Grosso; V.E. Do Rosário; Henrique Silveira. "Impacto da cloroquina nos mecanismos de defesa de Anopheles gambiae à infecção por Plasmodium berghei". 2007.
Conference poster
  1. Madeira, Carolina; Missionário, M.; Almeida, Célia; Cabral, Inês Moutinho; Nunes, Miguel; Fernandes, Joana F.; Travesso, Margarida; et al. "Molecular and phenotypic plasticity of temperate gobies in response to ocean warming and marine heatwaves.". Paper presented in Ciência 2023 - Encontro com a Ciência e Tecnologia em Portugal: Ciência e Oceano para Além do Horizonte, 2023.
  2. Gonçalves, C.; Moutinho Cabral, Inês; Rodrigo, Ana P.; Madeira, Carolina; Alves de Matos, A.P.; Grosso, Ana Rita; Costa, Pedro M.. "Uncovering the potential of Cephalopoda and Polychaeta toxins for drug discovery". Paper presented in Ciência 2023 - Encontro com a Ciência e Tecnologia em Portugal: Ciência e Oceano para Além do Horizonte, 2023.
  3. Cabral, Inês Moutinho; Missionário, M; Nunes, Miguel; Mendonça, Vanessa; Fernandes, Joana F.; Travesso, Margarida; Vinagre, Catarina; et al. "How ocean warming is modulating marine host-parasite dynamics in the Anthropocene: Evidence for higher parasite incidence and effects in nonwarm adapted intertidal fish population". Paper presented in EcoSummit 2023 Building a sustainable and desirable future: Adapting to a changing land and sea-scape, 13-17 June 2023 | Gold Coast, Australia, 2023.
  4. Caldas, Paulo; Luz, Mariana; Simone Baseggio; Rita Andrade; Grosso, Ana Rita. Corresponding author: Caldas, Paulo. "Transcription readthrough is prevalent in healthy human tissues and determined by inherent genomic features". Paper presented in RNA in Disease - RiboMed and IX ptRNA joint meeting, 2023.
  5. Caldas, Paulo; Grosso, Ana Rita; Luz, Mariana; Sobral, Daniel. Corresponding author: Grosso, Ana Rita. "RNA in Disease - IX PT RNA Meeting". Paper presented in Transcription Readthrough is prevalent in healthy human tissues and determined by inherent genomic features, 2023.
  6. Moutinho Cabral, Inês; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. "Bioprospecting marine environments for unraveling novel drugs: Transcriptomics and interactome-directed analyses of two toxin-secreting Polychaeta". Paper presented in 1st Egas Moniz One Health Symposium Teaming up for a better Public Health, 2022.
  7. Moutinho Cabral, Inês; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. "A study on whole-transcriptomes of two Polychaeta for discovering novel bioproducts with potential biotechnological applications". Paper presented in ICYMARE International Conference for Young Marine Researchers, 2021.
  8. Rodrigo, Ana; Grosso, Ana Rita; Mendes, Vera M; Manadas, Bruno; Pedro V. Baptista; Alexandra R Fernandes; Costa, Pedro M.. "Unveiling venomous annelids by combining omics with ecological traits: The example of a phyllodocid". Paper presented in XII European Conference on Marine Natural Products, 2021.
  9. Gonçalves, C.; Cabral, I.M.; Rodrigo, Ana P.; Fonseca, D. ; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. "A stinging issue: omics and computational tools for the bioprospecting for novel marine toxins". Paper presented in XII ECMNP, 2021.
  10. Cátia Gonçalves; Diogo Fonseca; Francisca Silva; Grosso, Ana Rita; Costa, Pedro M.. "New insights into cephalopods venoms ¿ A promising target for bioprospection". Paper presented in European Conference on Marine Natural Products (ECMNP2021), 2021.
  11. Sabino, João C.; Sridhara, Sreerama C.; Abreu, Patrícia L.; Domingues, Marco M.; Santos, Nuno C.; Grosso, Ana Rita; de Almeida, Sérgio F.. "Epigenetic determinants of transcription-coupled genomic instability". Paper presented in Trends in Genome Integrity & Chromosome Dynamics, 2020.
  12. Rodrigo, Ana P.; Grosso, Ana Rita; Baptista, Pedro; Alexandra R Fernandes; Costa, Pedro M.. "Toxins from an unsuspected invertebrate: a poisonous cocktail from a jawless predatory polychaete". Paper presented in XVI International symposium on marine natural products & XI European conference on marine natural products, 2019.
  13. Martins, Carla; Carvalho, L. M.; Grosso, Ana Rita; Saúde, Leonor; Costa, Pedro M.. "The interaction effects of carcinogenic toxicants and emerging pollutants in zebrafish embryos: A toxicopathological and genotoxicological approach". Paper presented in Ciência 2019, 2019.
  14. Paulino, Cathy; Fernandes, Alexandra R; Baptista, Pedro Viana; Soeiro, Cristina; Grosso, Ana Rita; Quintas, Alexandre. "Genetic predisposition for aggressive behaviour related with dopamine and serotonin pathways ¿ An overview". Paper presented in 4th International Congress of CiiEM Health, Well-Being and Ageing in the XXI Century, 2019.
  15. Gomes, AQ; Correia, DV; Grosso, Ana Rita; Lança, T; SILVA-SANTOS, Bruno. "Identification of a panel of cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gd T cells". Paper presented in 14th International Congress of Immunology, 2010.
  16. Patricia Abrantes; G. Dimopoulos; Ana Rita Grosso; V.E. Do Rosário; Henrique Silveira. "Impacto da cloroquina nos mecanismos de defesa de A. gambiae à infecção por P. berghei". 2007.
Journal article
  1. Paulo Caldas; Mariana Luz; Simone Baseggio; Rita Andrade; Daniel Sobral; Ana Rita Grosso. "Transcription readthrough is prevalent in healthy human tissues and associated with inherent genomic features". Communications Biology (2024): https://doi.org/10.1038/s42003-024-05779-5.
    10.1038/s42003-024-05779-5
  2. Bruno A. Cardoso; Mafalda Duque; Ana Gírio; Rita Fragoso; Mariana L. Oliveira; James R. Allen; Leila R. Martins; et al. "CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia". Haematologica (2023): http://dx.doi.org/10.3324/haematol.2023.282854.
    10.3324/haematol.2023.282854
  3. Carlota Pascoal; Mylène A. Carrascal; Daniela F. Barreira; Rita A. Lourenço; Pedro Granjo; Ana R. Grosso; Paula Borralho; Sofia Braga; Paula A. Videira. "Sialyl LewisX/A and Cytokeratin Crosstalk in Triple Negative Breast Cancer". Cancers (2023): https://doi.org/10.3390/cancers15030731.
    10.3390/cancers15030731
  4. Peixoto, Carolina; Lopes, Marta B.; Martins, Marta; Casimiro, Sandra; Sobral, Daniel; Grosso, Ana Rita; Abreu, Catarina; et al. "Identification of biomarkers predictive of metastasis development in early-stage colorectal cancer using network-based regularization". BMC Bioinformatics 24 1 (2023): http://dx.doi.org/10.1186/s12859-022-05104-z.
    10.1186/s12859-022-05104-z
  5. Marta F Fidalgo; Catarina G Fonseca; Paulo Caldas; Alexandre ASF Raposo; Tania Balboni; Lenka Henao-Mišíková; Ana R Grosso; Francisca F Vasconcelos; Cláudio A Franco. "Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes". Life Science Alliance (2022): https://doi.org/10.26508/lsa.202201554.
    10.26508/lsa.202201554
  6. Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; et al. "Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development". Communications Biology 5 1 (2022): http://dx.doi.org/10.1038/s42003-022-03884-x.
    10.1038/s42003-022-03884-x
  7. Daniel Sobral; Rita Francisco; Laura Duro; Paula Alexandra Videira; Ana Rita Grosso. "Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function". Biomedicines (2022): https://doi.org/10.3390/biomedicines10081805.
    10.3390/biomedicines10081805
  8. "A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth". Nature Metabolism 4 6 (2022): 672-682. http://dx.doi.org/10.1038/s42255-022-00584-y.
    10.1038/s42255-022-00584-y
  9. Ana P. Rodrigo; Ana Catarina Lopes; Ricardo Pereira; Sandra I. Anjo; Bruno Manadas; Ana Rita Grosso; P. V. Baptista; Alexandra Fernandes; Pedro M. Costa. "Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta". Marine Drugs 20 4 (2022): https://novaresearch.unl.pt/en/publications/14662f2c-d707-44e4-8a35-44d17cf7ffc7.
    10.3390/md20040224
  10. Sabino, João C; de Almeida, Madalena R; Abreu, Patrícia L; Ferreira, Ana M; Caldas, Paulo; Domingues, Marco M; Santos, Nuno C; et al. "Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops". eLife 11 (2022): http://dx.doi.org/10.7554/elife.69476.
    Open access • 10.7554/elife.69476
  11. Inês Moutinho Cabral; Carolina Madeira; Ana R. Grosso; Pedro M. Costa. "A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids: Glycera alba and Hediste diversicolor". Molecular Omics (2022): https://doi.org/10.1039/D2MO00138A.
    10.1039/D2MO00138A
  12. Vanda Póvoa; Cátia Rebelo de Almeida; Mariana Maia-Gil; Daniel Sobral; Micaela Domingues; Mayra Martinez-Lopez; Miguel de Almeida Fuzeta; et al. "Innate immune evasion revealed in a colorectal zebrafish xenograft model". Nature Communications (2021): https://doi.org/10.1038/s41467-021-21421-y.
    10.1038/s41467-021-21421-y
  13. Almeida, Afonso R. M.; Neto, João L.; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta B.; et al. "Interleukin-7 receptor a mutational activation can initiate precursor B-cell acute lymphoblastic leukemia". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-27197-5.
    10.1038/s41467-021-27197-5
  14. Silva, Ana Patricia; Almeida, Afonso R.M.; Cachucho, Ana; Neto, João L; Demeyer, Sofie; Ramos de Matos, Mafalda; Hogan, Thea; et al. "Overexpression of wild type IL-7Ra promotes T-cell acute lymphoblastic leukemia/lymphoma". Blood (2021): http://dx.doi.org/10.1182/blood.2019000553.
    10.1182/blood.2019000553
  15. Andrade, Jorge; Shi, Chenyue; Costa, Ana S. H.; Choi, Jeongwoon; Kim, Jaeryung; Doddaballapur, Anuradha; Sugino, Toshiya; et al. "Control of endothelial quiescence by FOXO-regulated metabolites". Nature Cell Biology 23 4 (2021): 413-423. http://dx.doi.org/10.1038/s41556-021-00637-6.
    10.1038/s41556-021-00637-6
  16. Ana P. Rodrigo; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa. "A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid". Toxins (2021): https://doi.org/10.3390/toxins13020097.
    10.3390/toxins13020097
  17. Ana P. Rodrigo; Vera M. Mendes; Bruno Manadas; Ana R. Grosso; António P. Alves de Matos; Pedro V. Baptista; Pedro M. Costa; Alexandra R. Fernandes. "Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells". Marine Drugs (2021): https://doi.org/10.3390/md19010031.
    10.3390/md19010031
  18. Rita Francisco; Carlota Pascoal; Dorinda Marques-da-Silva; Sandra Brasil; Fernando M. Pimentel-Santos; Ruqaiah Altassan; Jaak Jaeken; et al. "New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach". Journal of Clinical Medicine 9 7 (2020): 2092-2092. https://doi.org/10.3390/jcm9072092.
    10.3390/jcm9072092
  19. Prudêncio, Pedro; Rebelo, Kenny; Grosso, Ana Rita; Martinho, Rui Gonçalo; Carmo-Fonseca, Maria. "Analysis of Mammalian Native Elongating Transcript sequencing (mNET-seq) high-throughput data". Methods (2019): http://dx.doi.org/10.1016/j.ymeth.2019.09.003.
    10.1016/j.ymeth.2019.09.003
  20. Cunha, M.; Martins, C.; Grosso, A.R.; Costa, P.M.. "Mytilus galloprovincialis CYP1A-like mRNAs reveal closer proximity of mytilid CYP1A to the eumetazoan CYP2 family". Aquatic Toxicology 214 (2019): 105260. http://dx.doi.org/10.1016/j.aquatox.2019.105260.
    Published • 10.1016/j.aquatox.2019.105260
  21. de Matos, Mafalda; Posa, Ioana; Carvalho, Filipa; Morais, Vanessa; Grosso, Ana; de Almeida, Sérgio. Corresponding author: Grosso, Ana. "A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers". Cancers 11 3 (2019): 391. http://dx.doi.org/10.3390/cancers11030391.
    Published • 10.3390/cancers11030391
  22. Vítor, Alexandra C.; Sridhara, Sreerama C.; Sabino, João C.; Afonso, Ana I.; Grosso, Ana R.; Martin, Robert M.; de Almeida, Sérgio F.. "Single-molecule imaging of transcription at damaged chromatin". Science Advances 5 1 (2019): eaau1249. http://dx.doi.org/10.1126/sciadv.aau1249.
    10.1126/sciadv.aau1249
  23. Nojima, Takayuki; Rebelo, Kenny; Gomes, Tomas; Grosso, Ana Rita; Proudfoot, Nicholas J.; Carmo-Fonseca, Maria. "RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing". Molecular Cell 72 2 (2018): 369-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000447630200017&KeyUID=WOS:000447630200017.
    10.1016/j.molcel.2018.09.004
  24. Mancio-Silva, Liliana; Slavic, Ksenija; Grilo Ruivo, Margarida T.; Grosso, Ana Rita; Modrzynska, Katarzyna K.; Vera, Iset Medina; Sales-Dias, Joana; et al. "Nutrient sensing modulates malaria parasite virulence". Nature 547 7662 (2017): 213-216. http://dx.doi.org/10.1038/nature23009.
    10.1038/nature23009
  25. Grosso, Ana Rita. "Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability.". Molecular cell (2017): http://europepmc.org/abstract/med/28757210.
    10.1016/j.molcel.2017.07.002
  26. Sridhara, Sreerama Chaitanya; Carvalho, Sílvia; Grosso, Ana Rita; Gallego-Paez, Lina Marcela; Carmo-Fonseca, Maria; de Almeida, Sérgio Fernandes. "Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation". Cell Reports 18 2 (2017): 334-343. http://dx.doi.org/10.1016/j.celrep.2016.12.050.
    10.1016/j.celrep.2016.12.050
  27. Machado, Miguel P.; Matos, Isa; Grosso, Ana R.; Schartl, Manfred; Coelho, Maria M.. "Non-canonical expression patterns and evolutionary rates of sex-biased genes in a seasonal fish". Molecular Reproduction and Development 83 12 (2016): 1102-1115. http://dx.doi.org/10.1002/mrd.22752.
    10.1002/mrd.22752
  28. Posa, Ioana; Carvalho, Silvia; Tavares, Joana; Grosso, Ana Rita. Corresponding author: Grosso, Ana Rita. "A pan-cancer analysis of MYC-PVT1 reveals CNV-unmediated deregulation and poor prognosis in renal carcinoma". Oncotarget 7 30 (2016): http://dx.doi.org/10.18632/oncotarget.9487.
    10.18632/oncotarget.9487
  29. Muñoz-Ruiz, Miguel; Ribot, Julie C; Grosso, Ana R; Gonçalves-Sousa, Natacha; Pamplona, Ana; Pennington, Daniel J; Regueiro, José R; Fernández-Malavé, Edgar; Silva-Santos, Bruno. "TCR signal strength controls thymic differentiation of discrete proinflammatory ¿d T cell subsets". Nature Immunology 17 6 (2016): 721-727. http://dx.doi.org/10.1038/ni.3424.
    10.1038/ni.3424
  30. Jesus, T.F.; Grosso, A.R.; Almeida-Val, V.M.F.; Coelho, M.M.. "Transcriptome profiling of two Iberian freshwater fish exposed to thermal stress". Journal of Thermal Biology 55 (2016): 54-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951081833&partnerID=MN8TOARS.
    10.1016/j.jtherbio.2015.11.009
  31. Grosso, Ana R; Leite, Ana P; Carvalho, Sílvia; Matos, Mafalda R; Martins, Filipa B; Vítor, Alexandra C; Desterro, Joana MP; Carmo-Fonseca, Maria; de Almeida, Sérgio F. "Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma". eLife 4 (2015): http://dx.doi.org/10.7554/elife.09214.
    10.7554/elife.09214
  32. Álvarez, P.; Arthofer, Wolfgang; Coelho, Maria M.; Conklin, D.; Estonba, A.; Grosso, Ana R.; Helyar, S. J.; et al. "Genomic Resources Notes Accepted 1 June 2015 - 31 July 2015". Molecular Ecology Resources 15 6 (2015): 1510-1512. http://dx.doi.org/10.1111/1755-0998.12454.
    10.1111/1755-0998.12454
  33. Almeida-Val, Vera Maria Fonseca; Boscari, E.; Coelho, Maria Manuela; Congiu, L.; Grapputo, A.; Grosso, Ana Rita; Jesus, Tiago Filipe; et al. "Genomic Resources Notes accepted 1 April 2015 - 31 May 2015". Molecular Ecology Resources 15 5 (2015): 1256-1257. http://dx.doi.org/10.1111/1755-0998.12439.
    10.1111/1755-0998.12439
  34. Veigas, Bruno; Pedrosa, Pedro; Carlos, Fábio F; Mancio-Silva, Liliana; Grosso, Ana Rita; Fortunato, Elvira; Mota, Maria M; Baptista, Pedro V. "One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care". Journal of Nanobiotechnology 13 1 (2015): http://dx.doi.org/10.1186/s12951-015-0109-1.
    10.1186/s12951-015-0109-1
  35. Grosso, Ana Rita. "Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing". Cell (2015):
    http://dx.doi.org/10.1016/j.cell.2015.03.027
  36. Nojima, Takayuki; Gomes, Tomás; Grosso, Ana Rita Fialho; Kimura, Hiroshi; Dye, Michael J.; Dhir, Somdutta; Carmo-Fonseca, Maria; Proudfoot, Nicholas J.. "Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing". Cell 161 3 (2015): 526-540. http://dx.doi.org/10.1016/j.cell.2015.03.027.
    10.1016/j.cell.2015.03.027
  37. Grosso, A.R.; Leite, A.P.; Carvalho, S.; Matos, M.R.; Martins, F.B.; Vítor, A.C.; Desterro, J.M.P.; Carmo-Fonseca, M.; de Almeida, S.F.. Corresponding author: Grosso, A.R.. "Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma". eLife 4 NOVEMBER20 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958191482&partnerID=MN8TOARS.
    10.7554/eLife.09214
  38. Dourado, C.G.; Duarte, M.A.; Grosso, A.R.; Bastos-Silveira, C.; Marrero, P.; Oliveira, P.; Paulo, O.S.; Dias, D.. "Phylogenetic origin of the endemic pigeons from Madeira (Columba trocaz) and Azores Islands (Columba palumbus azorica)". Journal of Ornithology 155 1 (2014): 71-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891629909&partnerID=MN8TOARS.
    10.1007/s10336-013-0988-6
  39. Lança, T.; Costa, M.F.; Gonca¸lves-Sousa, N.; Rei, M.; Grosso, A.R.; Penido, C.; Silva-Santos, B.. "Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic ¿d T lymphocytes to tumor beds". Journal of Immunology 190 12 (2013): 6673-6680. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879112769&partnerID=MN8TOARS.
    10.4049/jimmunol.1300434
  40. Rodrigues, R.; Grosso, A.R.; Moita, L.. "Genome-Wide Analysis of Alternative Splicing during Dendritic Cell Response to a Bacterial Challenge". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876265387&partnerID=MN8TOARS.
    10.1371/journal.pone.0061975
  41. Carvalho, S.; Raposo, A.C.; Martins, F.B.; Grosso, A.R.; Sridhara, S.C.; Rino, J.; Carmo-Fonseca, M.; De Almeida, S.F.. "Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription". Nucleic Acids Research 41 5 (2013): 2881-2893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876365300&partnerID=MN8TOARS.
    10.1093/nar/gks1472
  42. Schmolka, N.; Serre, K.; Grosso, A.R.; Rei, M.; Pennington, D.J.; Gomes, A.Q.; Silva-Santos, B.. "Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory ¿d T cell subsets". Nature Immunology 14 10 (2013): 1093-1100. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886723991&partnerID=MN8TOARS.
    10.1038/ni.2702
  43. Grosso, A.R.; De Almeida, S.F.; Braga, J.; Carmo-Fonseca, M.. "Dynamic transitions in RNA polymerase II density profiles during transcription termination". Genome Research 22 8 (2012): 1447-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864577725&partnerID=MN8TOARS.
    10.1101/gr.138057.112
  44. De Almeida, S.F.; Grosso, A.R.; Koch, F.; Fenouil, R.; Carvalho, S.; Andrade, J.; Levezinho, H.; et al. "Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36". Nature Structural and Molecular Biology 18 9 (2011): 977-983. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052445151&partnerID=MN8TOARS.
    10.1038/nsmb.2123
  45. Gomes, A.Q.; Correia, D.V.; Grosso, A.R.; Lança, T.; Ferreira, C.; Lacerda, J.F.; Barata, J.T.; da Silva, M.G.; Silva-Santos, B.. "Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood ¿d t cells". Haematologica 95 8 (2010): 1397-1404. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956032245&partnerID=MN8TOARS.
    10.3324/haematol.2009.020602
  46. Mollet, I.G.; Ben-Dov, C.; Felício-Silva, D.; Grosso, A.R.; Eleutério, P.; Alves, R.; Staller, R.; Silva, T.S.; Carmo-Fonseca, M.. "Unconstrained mining of transcript data reveals increased alternative splicing complexity in the human transcriptome". Nucleic Acids Research 38 14 (2010): 4740-4754. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955793696&partnerID=MN8TOARS.
    10.1093/nar/gkq197
  47. Albuquerque, S.S.; Carret, C.; Grosso, A.R.; Tarun, A.S.; Peng, X.; Kappe, S.H.I.; Prudêncio, M.; Mota, M.M.. "Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events". BMC Genomics 10 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67650520138&partnerID=MN8TOARS.
    10.1186/1471-2164-10-270
  48. Correia, D.V.; D'Orey, F.; Cardoso, B.A.; Lança, T.; Grosso, A.R.; DeBarros, A.; Martins, L.R.; Barata, J.T.; Silva-Santos, B.. "Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human ¿d T-cells". PLoS ONE 4 5 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-66249119050&partnerID=MN8TOARS.
    10.1371/journal.pone.0005657
  49. Grosso, A.R.; Martins, S.; Carmo-Fonseca, M.. "The emerging role of splicing factors in cancer". EMBO Reports 9 11 (2008): 1087-1093. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549143293&partnerID=MN8TOARS.
    10.1038/embor.2008.189
  50. Grosso, A.R.; Gomes, A.Q.; Barbosa-Morais, N.L.; Caldeira, S.; Thorne, N.P.; Grech, G.; von Lindern, M.; Carmo-Fonseca, M.. "Tissue-specific splicing factor gene expression signatures". Nucleic Acids Research 36 15 (2008): 4823-4832. http://www.scopus.com/inward/record.url?eid=2-s2.0-50849145126&partnerID=MN8TOARS.
    10.1093/nar/gkn463
  51. Abrantes, P.; Dimopoulos, G.; Grosso, A.R.; do Rosario, V.E.; Silveira, H.. "Chloroquine mediated modulation of Anopheles gambiae gene expression". PLoS ONE 3 7 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-49749121787&partnerID=MN8TOARS.
    10.1371/journal.pone.0002587
  52. Amaral, A.J.; Silva, A.B.; Grosso, A.R.; Chikhi, L.; Bastos-Silveira, C.; Dias, D.. "Detection of hybridization and species identification in domesticated and wild quails using genetic markers". Folia Zoologica 56 3 (2007): 285-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-36048956045&partnerID=MN8TOARS.
  53. Grosso, A.R.; Bastos-Silveira, C.; Coelho, M.M.; Dias, D.. "Columba palumbus Cyt b-like Numt sequence: Comparison with functional homologue and the use of universal primers". Folia Zoologica 55 2 (2006): 131-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746876314&partnerID=MN8TOARS.
Preprint
  1. Silvia Carvalho; Luna Zea-Redondo; Tsz Ching Chloe Tang; Philipp Stachel-Braum; Duncan Miller; Paulo Caldas; Alexander Kukalev; et al. "SRRM2 splicing factor modulates cell fate in early development". 2023. https://doi.org/10.1101/2023.12.15.571825.
    10.1101/2023.12.15.571825
  2. Marta F. Fidalgo; Catarina G. Fonseca; Paulo Caldas; Alexandre A. S. F. Raposo; Tania Balboni; Ana R. Grosso; Francisca F. Vasconcelos; Cláudio A. Franco. "Alternative splicing changes are associated with pre-birth adaptation during lung development". 2022. https://doi.org/10.1101/2022.01.19.476886.
    10.1101/2022.01.19.476886
Thesis / Dissertation
  1. Grosso, Ana Rita Fialho, 1979-; Fonseca, M. Carmo, 1959-; Tavaré, Simon. "New insights into alternative splicing using microarray technology". PhD, 2009. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000576074.
  2. Grosso, Ana Rita. "Statistical Methodologies for the Analysis of DNA Microarray Data". Master, Universidade de Lisboa Faculdade de Ciências, 2006.

Other

Dataset
  1. Moutinho Cabral, Inês; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. Cysteine-rich venom protein from Glycera alba (Accession OL606744). GenBank.
  2. Moutinho Cabral, Inês; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. Serine protease inhibitor Kazal-type from Glycera alba (Accession OL606745). GenBank.
  3. Moutinho Cabral, Inês; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. Cysteine-rich secretory protein from Hediste diversicolor (Accession OL606746). GenBank.
  4. Moutinho Cabral, Inês; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. Thyrostimulin beta-5 subunit from Hediste diversicolor (Accession OL606747). GenBank.
  5. Moutinho Cabral, Inês; Madeira, Carolina; Grosso, Ana Rita; Costa, Pedro M.. Whole-transcritptome dataset for Glycera alba and Hediste diversicolor (Accession GSE196852). Gene Expression Omnibus.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/04 - Current Unveiling the molecular and cellular mechanisms underlying the regeneration blastema in marine annelids
Co-supervisor of Ines Cabral
 Biology (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - Current Multi-Omics approach to understand Congenital Disorders of Glycosylation
Co-supervisor of Cátia Neves
 Biology (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/01/01 - Current Coleoid venoms: Predicting cephalotoxin function and biotechnological applications from ecological and evolutionary traits
Co-supervisor of Cátia Gonçalves
 Biotechnology (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/01/01 - Current Decoding functional associations between genome organization and nuclear architecture
Co-supervisor of Silvia Carvalho
 Basic and Applied Biology (PhD)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2022/09 - 2023/12 BIT by BIT: Associating Transcription to Ageing
Co-supervisor of Ian Teixeira
 Computational Biology and Bioinformatics (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Depicting novel tumour cell states through single-cell transcriptome profiles
Supervisor of Francisca Xara-Brasil
 Biomedical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2022 Assessing the Prevalence of Transcription Readthrough in Human Healthy Tissues
Supervisor of Mariana Luz
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/02/01 - 2021/06/01 Bevacizumab Biomarkers in Triple Negative Breast Cancer
Supervisor of Ian Teixeira
 Biologia Celular e Molecular (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2021 A computational approach to identify target receptors of marine toxins in the human proteome: Potential biotechnological applications
Co-supervisor of Ines Cabral
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/02/01 - 2020/06/01 Depicting drivers of intra-tumor heterogeneity
Supervisor of João Milagaia
 Biologia Celular e Molecular (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/02/01 - 2020/06/01 Deciphering Transcriptome Alterations underlying Metastasis Development
Supervisor of Joana Gabriel
 Biologia Celular e Molecular (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/02/01 - 2019/06/01 Deciphering expression-profiles of glycosylation factors through computational multi-omics
Supervisor of Laura Duro
 Biologia Celular e Molecular (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/02/01 - 2019/06/01 Unveil tissue-specific expression of glycosylation factors through computational multi-omics
Supervisor of Valerio Fiori
 Biologia Celular e Molecular (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 Association of DNA modifications with somatic mutations in cancer
Supervisor of João Sousa
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2017 Depicting epigenetic mechanisms involved in the regulation of pseudogene expression
Supervisor of Ana Margarida Ferreira
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Assessing Pseudogene Expression during Neural Differentiation by RNA-seq
Supervisor of Luis Simões
 Bioinformática e Biologia Computacional (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2015 LincRNA profile in clear cell Renal Cell Carcinoma using RNA-seq data
Supervisor of Ioana Posa
 Bioinformática e Biologia Computacional (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Genome-wide profiling of RNA polymerase II and associated co- transcriptional processes using advanced NET-seq data
Supervisor of Tomás Gomes
 Bioinformática e Biologia Computacional
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 LincRNA's Profile in SETD2 Downregulated Cells
Supervisor of Joana Tavares
 Bioinformática e Biologia Computacional (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Study of the role of SETD2 mutations in clear renal Cell Carcinoma (ccRCC)
Co-supervisor of Catarina de Almeida
 Bioestatística (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Intragenic Initiation in SETD2 deficient cells
Co-supervisor of Miguel Pereira
 Bioestatística (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020 - Current 3 Monthly Seminar Series: leadingIDEAS@UCIBIO; BioSeminars@UCIBIO; GuestSeminars@UCIBIO (2020)
Seminar (Member of the Organising Committee)
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2020/07/06 - 2020/07/10 EMBO Practical Course on "Deciphering tumour heterogeneity and evolution by integration of multi-omics data". (2020/07/06)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2017 Seminar Series: Computational Biology and Bioinformatics (biweekly) (2012 - 2017)
Seminar (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2015 - 2015 iMM Liboa Post-Doc Day (2015 - 2015)
Meeting (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2010 - 2010 EURASNET Network Meeting in Lisbon (2010 - 2010)
Congress (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2009 - 2009 iMM Lisboa PhD Day (2009 - 2009)
Meeting (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/02 Unravelling the roles of proteotoxic stress on genome diversification and disease
(Thesis) Arguer
 Ines Sousa (PhD)
Universidade de Aveiro, Portugal
2023/12 Characterization of malignant cell transformation induced by cancer-derived exosomes
(Thesis) Main arguer
 Margarida Quaresma (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/11 Unveiling Novel Glioma Biomarkers through Multi-omics Integration and Classification
(Thesis) Main arguer
 Francisca Vieira (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/04 Developing Web Apps for Analyses of Transcriptomes
(Thesis) Arguer
 Nuno Agostinho (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/02/08 The Role of Muscle in Spondyloarthritis
(Thesis) Arguer
 Atlas Sardoo (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2022/12/21 A systems approach to the mechanisms of neurodegeneration
(Thesis) Arguer
 Marina Garcia-Vaquero (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/11/02 Computational Biology for Modeling Oncological Omics Data: the way towards personalized medicine
(Thesis) Main arguer
 Ana Carolina Peixoto (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/07/04 Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
(Thesis) Main arguer
 Rita Mendes (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/04/28 Dissecting the differential molecular signature in patients from african-origin with triple-negative breast cancer
(Thesis) Main arguer
 Ana Teresa Matias (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 Unveiling the regulation of germinal centre responses and antibody production by follicular T cells
Thesis Member
 Saumya Kumar (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 The transcriptional landscape of Alzheimer’s and Parkinson’s diseases
(Thesis) Main arguer
 Marie Bordone (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 RNA-seq analysis to unravel the molecular players involved in implantation/rejection of human tumor cells in zebrafish
(Thesis) Main arguer
 Micaela Domingues (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 A systematic pan-cancer analysis of somatic variants reveals epigenetic drivers of intratumor heterogeneity
Thesis Member
 Mafalda de Matos (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 Splicing kinetics revealed by nascent transcript sequencing
(Thesis) Main arguer
 Kenny Rebelo (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 Analysis of the contribution of alternative splicing to glioma subtype definition
(Thesis) Main arguer
 Teresa Maia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 Familial genetics of primary spontaneous pneumothorax
(Thesis) Main arguer
 David Francisco (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 Analysis of RNA-seq data from the interaction of Coffea spp. - Colletotrichum kahawae
(Thesis) Main arguer
 Joana Fino (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 Transcriptome profiling of spinal muscular atrophy models using RNA-Seq
(Thesis) Main arguer
 Francisco Brito (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 Statistical methodologies for the analysis and normalization of rip-chip data,
(Thesis) Main arguer
 Emiliano Hernandez (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 In silico analysis of miRNA promoters
(Thesis) Main arguer
 Fernando Martins (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - Current Communications Biology (2399-3642) Springer Nature
2014 - Current Bioinformatics Oxford University Press
2014 - Current BMC Bioinformatics Springer Nature
2014 - Current BMC Cancer Springer Nature
2014 - Current BMC Genomics Springer Nature
2014 - Current Epigenomics Future Medicine
2014 - Current Oncotarget Impact Journals

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Member of the UCIBIO Council at FCT-NOVA
Member
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2020 - Current Member of the Council of the Department of Life Sciences (DCV) at FCT-NOVA
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 - Current Member of the Working Group for Communication at UCIBIO
Member
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - Current Applied Computational Multi-Omics MSc in Computational Biology and Bioinformatics (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - Current Gene Expression Modulation MSc in Computational Biology and Bioinformatics (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - Current Introduction to Bioinformatics BSc in Cell and Molecular Biology (Bacharelato) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - Current Molecular Genetics BSc in Cell and Molecular Biology (Bacharelato) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - Current Fundamentals of Computational Biology MSc in Computational Biology and Bioinformatics (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - Current Molecular Genomics and Evolution MSc in Molecular Genetics and Biomedicine (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - Current Bioinformatics in Biomedicine MSc in Molecular Genetics and Biomedicine (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/02/06 - 2024/02/06 Computational Biosciences using HPC (2nd Edition) (Outros) Unidade de Ciências Biomoleculares Aplicadas, Portugal
2022/09/12 - 2022/09/12 Computational Biosciences using HPC (Outros) Unidade de Ciências Biomoleculares Aplicadas, Portugal
2012 - 2015 Computational Biology in Biomedicine MSc in Bioinformatics and Computational Biology (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2015 Bioinformatics MSc in Oncobiology (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023 - Current Marie-Curie PostDoctoral Fellowships
Evaluator
 European Commission Marie Sklodowska-Curie Actions, Belgium

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current Communications Biology (2399-3642) Springer Nature

Mentoring / Tutoring

Topic Student name
2021 - Current PhD Committee Member (as external member) Rita Silva
2019 - Current PhD Committee Member (as external member) Tânia Marques
2018 - Current PhD Committee Member (as external member) Mariana Ferreira
2022 - 2024 Marie-Curie PostDoctoral Fellow Paulo Caldas
2018 - 2023 PhD Committee Member (as external member) Nuno Agostinho
2018 - 2023 PhD Committee Member (as external member) Catarina Mendes
2020 - 2022 Postdoctoral Researcher Supervision Paulo Caldas
2019 - 2021 Postdoctoral Researcher Supervision João Neto
2019 - 2020 Young Researcher Supervision (MSc Holder Fellow) Rui Pinto
2018 - 2019 Postdoctoral Researcher Supervision Mafalda de Matos
2016 - 2017 Young Researcher Supervision (MSc Holder Fellow) Ana Margarida Ferreira
2013 - 2017 PhD Committee Member (as external member) Miguel Machado
2013 - 2017 PhD Committee Member (as external member) Tiago Jesus
2015 - 2016 Young Researcher Supervision (MSc Holder Fellow) Ioana Posa
Distinctions

Award

2021 Pfizer Award
Pfizer Portugal, Portugal
2017 Pfizer Award
Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal
2011 Pfizer Award
Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal

Other distinction

2018 FCT CEEC individual
Fundação para a Ciência e a Tecnologia, I.P., Portugal
2014 FCT Investigator
Fundação para a Ciência e a Tecnologia, I.P., Portugal
2010 FCT Post-Doctoral Fellowship
Fundação para a Ciência e a Tecnologia, I.P., Portugal
2006 PhD Fellowship
Fundação para a Ciência e a Tecnologia, I.P., Portugal