Regina Menezes Echaniz (3E12-EC8C-C4FC)

Curriculum Vitae

Regina Menezes Echaniz

R. Menezes is the CBIOS Director of Societal Impact and Community Engagement and Principal Investigator in the Models & Molecular Mechanisms Lab, where she coordinates the Diabetes research team. Her research has been driven by a deep curiosity about the genetic reprogramming that orchestrates cellular adaptation to environmental stimuli, in the areas of Genetics and Molecular Biology. With a degree in Biological Sciences and a MSc in Biological Sciences - Genetics, she enrolled in the PhD Program in Genetics at UFRJ, where she was awarded a highly competitive scholarship by DAAD to do experimental research at the Institut für Mikrobiologie - HHUD. Her doctoral studies significantly advanced our understanding of the molecular switch that governs carbon source utilization in model eukaryotic organisms. As a post-doc at UNL, her focus remained on the exploration of cellular adaptive responses. Her international reputation in yeast genetics was consolidated in 2013, when a European consortium set her a compelling challenge: to establish a SMART (Simple Molecular Architecture Research Tool) yeast platform tailored to the bioprospecting of molecules with therapeutic interest. The project proved to be remarkably successful on various fronts, ranging from the design of pioneering model organisms to the discovery of novel bioactive compounds. In this project, she developed an innovative yeast model that faithfully replicates the proteotoxic effects of IAPP, culminating in beta-cell dysfunction and loss in diabetes. These discoveries catalyzed a fundamental shift in her research focus towards diabetes in 2016. Since then, her team, first at IBET and currently at CBIOS, has been dedicated to elucidating the health-promoting attributes of dietary (poly)phenolic metabolites to counteract IAPP-induced beta-cell dysfunction and to promote the increase of beta-cell mass. She has been recognized in clinical spheres, through the Nuno Castelo-Branco Prize by SPD, research grants from the Portuguese Funding Agency, and iNova4Health Translational Medicine Program. Her team has been also supported by prestigious FCT and Fulbright scholarships for doctoral studies and advanced training.

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Identification

Personal identification

Full name: Regina Menezes Echaniz

Citation names

Regina Menezes
Regina de A. Menezes
Regina de Andrade Menezes

Author identifiers

Ciência ID: 3E12-EC8C-C4FC
ORCID iD: 0000-0003-0552-8480
Google Scholar ID: Regina Menezes
Researcher Id: L-3792-2014
Scopus Author Id: 7006750309

Email addresses

regina.menezes@ulusofona.pt (Professional)

Addresses

Universidade Lusófona - Centro Universitário de Lisboa - Campo Grande, 376 , 1749 - 024, Lisbon, Lisbon, Portugal (Professional)

Websites

http://cbios.ulusofona.pt (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Molecular Biology
Natural sciences - Biological Sciences - Biochemistry
Natural sciences - Biological Sciences - Cell Biology
Medical and Health Sciences - Health Sciences - Nutrition, Dietetics
Medical and Health Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Proficiency (C2)	Proficiency (C2)	Advanced (C1)	Proficiency (C2)	Advanced (C1)
German	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2019/09/09 - 2019/09/20 Concluded	Laboratory Animal Science Accreditation, FELASA Cat. C (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/10/18 - 2018/10/18 Concluded	Project management course: PRINCE2® and PMBOK® (Outros) Instituto de Biologia Experimental e Tecnológica, Portugal
2016/06/20 Concluded	Equivalency of the PhD degree in Biology (Doutoramento) Major in Genetics Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Interaction between Gal1 and Gal80 in the regulation of galactose metabolism in Kluyveromyces lactis" (THESIS/DISSERTATION)
2002/02/18 Concluded	Biological Sciences - Genetics PhD (Doutoramento) Major in Genetics Universidade Federal do Rio de Janeiro, Brazil Heinrich-Heine-Universität Düsseldorf, Germany "Interaction between Gal1 and Gal80 in the regulation of galactose metabolism in K Kluyveromyces lactis" (THESIS/DISSERTATION)	3/3
1997/03/21 Concluded	Biological Sciencies - Genetics MSc (Mestrado) Major in Genetics Universidade Federal do Rio de Janeiro, Brazil "rDNA physical mapping of yeast in the genus Metschinikowia" (THESIS/DISSERTATION)	2.91/3
1994/03 Concluded	Biological Sciences BSc (Licenciatura) Universidade Federal do Rio de Janeiro, Brazil " Analysis and comparison of D. albiventris and D. aurita rDNA Restriction Patterns" (THESIS/DISSERTATION)

Affiliation

Science

	Category Host institution	Employer
2020/12/01 - Current	Auxiliary Researcher (Research)	Cooperativa de Formação e Animação Cultural CRL, Portugal
	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2019/02/01 - 2023/12/31	Visiting Researcher (Research)	Universidade Nova de Lisboa, Portugal
	iNOVA4Health, Portugal (...)
2018/09/01 - 2020/11/30	Contracted Researcher (Research)	Instituto de Biologia Experimental e Tecnológica, Portugal

2014/01/01 - 2018/08/31	Postdoc (Research)	Instituto de Biologia Experimental e Tecnológica, Portugal

2013/08/01 - 2013/12/31	Postdoc (Research)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003/01/01 - 2013/07/30	Postdoc (Research)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2020/12/01 - Current	Assistant Professor (University Teacher)	Cooperativa de Formação e Animação Cultural CRL, Portugal
	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2023/09 - 2024/02	Invited Assistant Professor (University Teacher)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa, Portugal
2021/09 - 2022/02	Invited Assistant Professor (University Teacher)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa, Portugal
2020/09/01 - 2021/02	Invited Assistant Professor (University Teacher)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Positions / Appointments

	Category Host institution	Employer
2024/03 - Current	Societal Impact and Community Engagement Director	Cooperativa de Formação e Animação Cultural CRL, Portugal
	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal

Others

	Category Host institution	Employer
1997/08/01 - 2002/02/01	PhD student	Universidade Federal do Rio de Janeiro, Brazil
	Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde, Brazil
1997/09/01 - 2000/02/01	PhD student	Heinrich-Heine-Universität Düsseldorf, Germany

1994/08/01 - 1997/07/01	MSc student	Universidade Federal do Rio de Janeiro, Brazil
	Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde, Brazil

Projects

Grant

	Designation	Funders
2023/12/01 - Current	Research Platform of Bioactive Compounds by Artificial Intelligence (Plataforma de Pesquisa de Compostos Bioativos por Inteligência Artificial) COFAC/ILIND Researcher Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal	COFAC-ILIND Ongoing
2023/09/01 - Current	Exploring Unconventional Plant-Derived Metabolites to Keep Away Diabetes: The case of Pomegranate FAZER+/ILIND/CBIOS/1/2023 Principal investigator Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal	COFAC-ILIND Ongoing
2021/12/01 - Current	Dietary Patterns and Body Composition: Implications for Metabolic and Cardiovascular Health COFAC/ILIND/CBIOS/2/2021 Principal investigator Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal	COFAC-ILIND Ongoing
2018/01/01 - 2022/12/31	CHIC - Chicory as a multipurpose crop for dietary fibre and medicinal terpenes BIOTEC-07-2017 RIA 760891-2 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal	European Commission Concluded
2018/09/01 - 2022/08/31	Therapeutics@DIAPP_Perceiving Diabetes as an Islet Amyloid PoliPeptide oligomeropathy: disease progression and therapeutic focus PTDC/BIA-MOL31104/2017 Principal investigator Instituto de Biologia Experimental e Tecnológica, Portugal Associacao Protectora dos Diabeticos de Portugal, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/11/01 - 2021/11/30	Nature Bioactive Food - Desenvolvimento de produtos e ingredientes alimentares bioativos através de recursos agrícolas endógenos portugueses para uma alimentação saudável (Development of bioactive food products and ingredients through Portuguese endogenous agricultural resources for healthy eating) PDR2020-101-031529 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2021/09/30	Development of a sustainable biorefinery process towards the valorisation of fish processing wastes PTDC/ASP-PES/28399/2017 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2021/09/30	SilverBrain_From sea to brain: Green neuroprotective extracts for nanoencapsulation and functional food production FCT/MCES/2018 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/01 - 2020/11	Oil4Health: From Olive To Health LISBOA-01-0247-FEDER-038554 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal	Concluded
2017/11/01 - 2019/12/31	TherDIAPP_Islet Amyloid Polypeptide oligomers as critical entities in diabetes: early diagnosis and therapeutic focus UID/Multi/04462/2013-SubProj Inova4health 44 UID/Multi/04462/2019-SubProj Inova4health C44 Principal investigator Instituto de Biologia Experimental e Tecnológica, Portugal Associacao Protectora dos Diabeticos de Portugal, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/10/31	iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB) UID/Multi/04462/2019 Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Universidade Nova de Lisboa Medical School, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/11/01 - 2016/10/31	BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits FP7-KBBE-2013-613793 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal	European Commission Concluded
2014 - 2015	Exploration of novel molecular mechanisms involved in iron homeostasis FCT/3599-PPCDT/135550/PT Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Control of iron homeostasis by the Yeast Activator Proteins (Yaps) in eukaryotic cells PTDC/BIA-MIC/108747/2008 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01 - 2011/12	Implementation of a National Facility for DNA Microarrays: Phase II Provided by PTCRIS: 64745 PTDC/BIA-BCM/64745/2006 Researcher Universidade de Aveiro, Portugal Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2003 - 2005	Role of the transcription factors Yap proteins in Stress responses of the budding yeast Saccharomyces cerevisiae Sapiens 34967/99 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2011/01/01 - 2012/12/31	Strategic Project - LA 4 - 2011-2012 PEst-OE/EQB/LA0004/2011 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Fundação Calouste Gulbenkian, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2022/01 - Current	Clube Ciência Viva na Escola Básica Integrada da Quinta do Conde (Living Science Club at Quinta do Conde Integrated Basic School) PRR_ID: 734 Researcher Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal	Ciência Viva Ongoing
2010 - 2011	Yap8 regulon under arsenic stress Bilateral Cooperation Program (People Program) FCT/ANR Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2010	Arsenic and cadmiun molecular detoxification mechanisms using the model Saccharomyces cerevisiae Bilateral Cooperation Program -FCT/CAPES Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Claudia Nunes dos Santos; Regina Menezes; Carregosa, Diogo; Katarina Valentova; Alexandre Foito; Gordon McDougall; Derek Stewart. "Chapter 5: Flavones and Flavonols". In Dietary Polyphenols : Their Metabolism and Health Effects, edited by Francisco A . Tomas-Barberan; Antonio Gonzalez-Sarrias; Rocio Garcia-Villalba, 189-259. New York, United States, United States: John Wiley & Sons Inc, 2020. Published Garcia, G.; Santos, C. Nunes do; Menezes, R.. "High-Throughput Yeast-Based Reporter Assay to Identify Compounds with Anti-inflammatory Potential". In Methods in Molecular Biology, edited by Rune Matthiesen, 441-452. Springer New York, 2016. Published • 10.1007/978-1-4939-3756-1_29 Menezes R; Nevitt T; Rodrigues-Pousada C. "Transcrição em eucariontes e sua regulação (Transcription regulation in eukaryotes)". In O Mundo do RNA” (RNA world), edited by Cecília Arraiano; Arsénio Fialho. Lidel Edições Técnicas, 2007. Published
Conference abstract	Fontes, Tatiana; Lopes, Sofia; Regina de A. Menezes; Cebola, Marisa; Rodrigues, LM; Ferreira-Pêgo, Cíntia. Corresponding author: Ferreira-Pêgo, Cíntia. "Impact of diet quality on cardiovascular risk and its risk factors: comparison between omnivorous and vegetarian individuals". Paper presented in XXVI Congresso APNEP 2024, Porto, 2024. Monteiro Rodrigues, L.; Menezes, R.; Andrade, S.; Fontes, T.; Lopes, S.; Ferreira-Pêgo, Cíntia. Corresponding author: Ferreira-Pêgo, Cíntia. "Dietary pattern, body composition, metabolic markers, and skin physiology". Paper presented in American Physiology Summit 2023 Meeting, California, 2023. Published • https://doi.org/10.1152/physiol.2023.38.S1.5790039 Monteiro Rodrigues, L.; Farrim, M.I.; Gomes, A.; Milenkivic, D.; Menezes, R.. "Pancreatic islet cell reprogramming into insulin producers: a multi-omics approach". Paper presented in American Physiology Summit 2023, California, 2023. Published • https://doi.org/10.1152/physiol.2023.38.S1.5790033 Monteiro Rodrigues, L.; Ferreira, S.; Raimundo, A.; Pobre, V.; Garcez, M.; Silva, M.; Brito, J.; et al. "Metabolism-insulin secretion coupling in pancreatic beta-cells: the protective role of urolithin B towards IAPP aggregation, insulin release and mitochondrial respiration". Paper presented in American Physiology Summit 2023, California, 2023. Published • https://doi.org/10.1152/physiol.2023.38.S1.5790088 Fontes, Tatiana; Lopes, Sofia; Regina de A. Menezes; Cebola, Marisa; Rodrigues, LM; Ferreira-Pêgo, Cíntia. Corresponding author: Ferreira-Pêgo, Cíntia. "Body composition and cardiovascular risk: a comparison between vegetarians and omnivores". Paper presented in XXII Congresso de Nutrição e Alimentação, Porto, 2023. Published Caetano, SM; Menezes, R ; Amaral, C ; Rodrigues-Pousada, C ; Pimentel, C. "Yap1-mediated repression of the yeast low affinity iron transporter gene, FET4, confers cadmium tolerance". Paper presented in FEBS EMBO 2014 Conference, Paris, 2014. Pimentel, C; Caetano, S; Menezes, R; Figueira, I; Santos, CN; Ferreira, RB; Santos, M; Rodrigues-Pousada, C. "Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae". Paper presented in 38th Congress of the Federation of European ruBiochemical-Societies (FEBS), Saint Petersburg, 2013. Pereira, J; Pimentel, C; Amaral, C; Menezes, R; Rodrigues-Pousada, C. "Yap4 PKA- and GSK3-dependent phosphorylation affects its stability but not its nuclear localization". Paper presented in 34th Congress of the Federation of European Biochemical Societies, Prague, 2009. Batista-Nascimento, L; Menezes, R.; Thiele, D.; Rodrigues-Pousada, C.. "The ubiquitin chain assembly factor Ufd2/E4 contributes to full arsenic adaptation in Saccharomyces cerevisiae". Paper presented in 34th Congress of the Federation of European Biochemical Societies, Prague, 2009. Batista-Nascimento, LS; Pimentel, C; Menezes, R; Rodrigues-Pousada, C. "Yapo mutant: A tool to explore the functional overlap of Yap1, Yap2 and Yap8". Paper presented in 32nd Congress of the Federation of European Biochemical Societies (FEBS), Vienna, 2007. Amaral, C; Menezes, R; Nascimento, L; Eleutherio, E; Devaux, F; Rodrigues-Pousada, C. "Yap1 and Yap8 mediated response in yeast to arsenic stress". Paper presented in 32nd Congress of the Federation of European Biochemical Societies (FEBS), Vienna, 2007. Nascimento, L; Menezes, R; Nevitt, T; Amaral, C; Rodrigues-Pousada, C. "Yap0 super-mutant - a tool to study the functional role of the Yap family members". Paper presented in 31st Congress of the Federation of European Biochemical Societies (FEBS), Istanbul, 2006. Menezes, R; Amaral, C; Rodrigues-Pousada, C. "Characterization of the function of YAP family members: involvement of Yap8p with arsenite- and arsenate-resistance mechanism". Paper presented in 21st International Conference on Yeast Genetics and Molecular Biology, Gothenburg, 2003.
Conference poster	Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Dragan Milenkovic. "The impact of polyphenols on diabetes. mechanisms and therapeutic potential". Paper presented in 3º Encontro Internacional da Sociedade Portuguesa de Fisiologia, 2024. Gomes, Andreia; Emilia Borba Alves; Andrade, Rita; Samanta Colares; João F. Raposo; Rogério Ribeiro; Regina de A. Menezes. "Desregulação do IAPP e Função das Células ß na Diabetes: Um Estudo Transversal". Paper presented in 6º Congresso Nacional da APDP, 2024. Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Milenkovic, Dragan. "Potencial terapêutico dos (poli)fenóis na diabetes: efeitos e mecanismos de ação". Paper presented in 6º Congresso Nacional da APDP, 2024. Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Milenkovic, Dragan. "Disclosing the potential of (Poly)phenols in Managing Diabetes: from effects to mechanisms of action". Paper presented in 11th Annual ICPH Conference, 2024. Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Dragan Milenkovic. "Exploring the molecular mechanisms underlying (poly)phenol health-promoting activities against diabetes". Paper presented in 60th European Association for the Study of Diabetes, 2024. Emilia Borba Alves; Gomes, Andreia; Andrade, Rita; José F. Raposo; Rogério Ribeiro; Regina de A. Menezes. "Iapp and ß-cell dysfunction in diabetes: a cross-sectional study". Paper presented in 60th European Association for the Study of Diabetes, 2024. Alves, Emília; Gomes, Andreia; Andrade, Rita; Colares, Samanta; Fontes, Tatiana; Ferreira-Pêgo, Cíntia; JOAO FILIPE RAPOSO; Ribeiro, Rogério José Tavares; Regina de A. Menezes. "Evaluating metabolic health and lifestyle factors in individuals with type 2 diabetes mellitus: insights from a cross-sectional study". Paper presented in XXIII Congresso de Nutrição e Alimentação, 2024. Ferreira, Sofia; Gomes, Andreia; Emilia Borba Alves; Raimundo, Ana; Farrim, Maria I.; Rita Andrade; J. F. Raposo ; et al. Corresponding author: Regina de A. Menezes. "IAPP and ß-cell dysfunction in diabetes: unveiling the protective potential of urolithins". Paper presented in 3rd Annual Meeting of the ProteoCure COST Action, 2024. Ferreira-Pêgo, Cíntia; Fontes, Tatiana; Lopes, Sofia; Regina de A. Menezes; Rodrigues, LM. "Vegetarianism and Cardiovascular Health". Paper presented in American Physiology Summit 2024, 2024. Alves, Emília; Gomes, Andreia; Andrade, Rita; Colares, Samanta; Fontes, Tatiana; Ferreira-Pêgo, Cíntia; JOAO FILIPE RAPOSO; Ribeiro, Rogério José Tavares; Regina de A. Menezes. "Assessing Well-being Levels in Individuals with Type 2 Diabetes: A Cross-Sectional Study". Paper presented in IV Jornadas Lusófonas de Nutrição, 2024. Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Milenkovic, Dragan. Corresponding author: Milenkovic, Dragan. "The potential role of dietary (poly)phenols in diabetes". Paper presented in IV Jornadas Lusófonas de Nutrição, 2024. Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Milenkovic, Dragan. Corresponding author: Milenkovic, Dragan. "(Poli)fenóis e a diabetes: dos efeitos aos mecanismos de ação". Paper presented in Congresso Português da Diabetes, 2024. Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Dragan Milenkovic. "(Poli)fenos e a diabetes: dos efeitos aos mecanismos de ação". Paper presented in 20º Congresso Português de Diabetes, 2024. Regina de A. Menezes; Farrim, Maria I.; Gomes, Andreia; Dragan Milenkovic. "Integrative multi-omics approach for pancreatic islet reprogramming into insulin producers". Paper presented in V CBIOS Seminar, 2023. Menezes, R.; Rosado-Ramos, Rita; Godinho-Pereira, J.; Costa, I.; Jardim, C.; Garcia, G; Foito, A.; Stewart, D.. "Bioprospection of phytochemicals mitigating cytotoxicity induced by aggregation-prone proteins". Paper presented in 3rd Proteostasis Action Meeting (Lisboa, Portugal), 2016. Regina Menezes, Regina A Menezes or Regina de Andrade Menezes; Jardim, C.; Costa, I.; Garcia, G; Rosado-Ramos, Rita; Foito, A.; Stewart, D.; Nunes dos Santos, Cláudia. "Novos polifenóis com potencial terapêutico revelados através da bioprospeção da biodiversidade dos pequenos frutos". Paper presented in V Colóquio nacional da produção de pequenos frutos (Oeiras, Portugal), 2016. Regina Menezes, Regina A Menezes or Regina de Andrade Menezes; Costa, I.; Jardim, C.; Garcia, G; Foito, A.; Stewart, D.; Nunes dos Santos, Cláudia. "Bioprospection of a berry germplasm for the identification of novel therapeutic (poly)phenols using a humanized yeast platform". Paper presented in 7th International Conference on Polyphenols and Health (ICPH) (Tours, France), 2015. Garcia, G; Maria Paula S F S Pinto; Regina Menezes, Regina A Menezes or Regina de Andrade Menezes; Dobson, G.; McDougall, G.J.; Stewart, D.; Boavida Ferreira, Ricardo; Nunes dos Santos, Cláudia. "Attenuation of neuroinflammation by raspberry (poly)phenols". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 5th PF2MUC Symposium, satellite meeting “Zoom in microglia” (Coimbra, Portugal), 2014. Garcia, G; Maria Paula S F S Pinto; Regina Menezes, Regina A Menezes or Regina de Andrade Menezes; Dobson, G.; McDougall, G.J.; Stewart, D.; Boavida Ferreira, Ricardo; Nunes dos Santos, Cláudia. "(Poly)phenols from quasi-isogenic raspberries: Benefits for brain health". Paper presented in EuBerry final meeting (Mszczonów, Poland), 2014.
Encyclopedia entry	Regina Menezes; Paulo Matafome; Freitas, Marisa; María-Teresa García-Conesa. "The Evidence of Benefits of (Poly)phenols against T2DM". In Scholarly Community Encyclopedia, 2022. Costa, J.G.; Guerreiro, Í.; Ferreira-Pêgo, C.; Carregosa, D.; Santos, C.N.; Menezes, R.; Fernandes, A.. "Polyphenols in Renal Pathophysiology". In Scholarly Community Encyclopedia, 2022. https://encyclopedia.pub/entry/21925. Accepted
Journal article	Farrim, Maria Inês; Gomes, Andreia; Menezes, Regina; Milenkovic, Dragan. "(Poly)phenols and diabetes: From effects to mechanisms by systematic multigenomic analysis". Ageing Research Reviews 102 (2024): 102557. http://dx.doi.org/10.1016/j.arr.2024.102557. 10.1016/j.arr.2024.102557 Tatiana Fontes; Sofia Lopes; Regina Menezes; Marta Esgalhado; Luís Monteiro Rodrigues; Cíntia Ferreira-Pêgo. "Exploring Vegetarian and Omnivorous Approaches to Cardiovascular Risk and Body Composition". Nutrients (2024): https://doi.org/10.3390/nu16132013. 10.3390/nu16132013 E. Alves; S. Ferreira; M.I. Farrim; R. Menezes. "ß-cell Exhaustion and Islet Microenvironment: The Role of Local Vascular Network". Revista Portuguesa de Diabetes 19 1 (2024): 3-10. Open access • Accepted Farrim, M. I.; Gomes, A.; Milenkovic, D.; Menezes, R.. "Gene expression analysis reveals diabetes-related gene signatures". Human Genomics 18 1 (2024): http://dx.doi.org/10.1186/s40246-024-00582-z. 10.1186/s40246-024-00582-z Sofia Lopes; Tatiana Fontes; Regina Menezes; Luís Monteiro Rodrigues; Cíntia Ferreira-Pêgo. "Mediterranean Diet Adherence and Its Relationship to Metabolic Markers and Body Composition in Portuguese University Students". Nutrients (2023): https://doi.org/10.3390/nu15102330. 10.3390/nu15102330 Rosado-Ramos, Rita; Poças, Gonçalo M.; Marques, Daniela; Foito, Alexandre; M. Sevillano, David; Lopes-da-Silva, Mafalda; Gonçalves, Luís G.; et al. "Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37561-2. 10.1038/s41467-023-37561-2 Ana Marta de Matos; Regina Menezes. "The (Poly)phenol-Carbohydrate Combination for Diabetes: Where Do We Stand?". Nutrients (2023): https://doi.org/10.3390/nu15040996. 10.3390/nu15040996 Raimundo, Ana F.; Ferreira, Sofia; Pobre, Vânia; Lopes-da-Silva, Mafalda; Brito, José A.; dos Santos, Daniel J. V. A.; Saraiva, Nuno; dos Santos, Cláudia N.; Menezes, Regina. "Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes". Frontiers in Endocrinology 13 (2022): http://dx.doi.org/10.3389/fendo.2022.1008418. 10.3389/fendo.2022.1008418 Marangoni, Karina; Menezes, Regina. "RNA Aptamer-functionalized Polymeric Nanoparticles in Targeted Delivery andCancer Therapy: An up-to-date Review". Current Pharmaceutical Design 28 34 (2022): 2785-2794. http://dx.doi.org/10.2174/1381612828666220903120755. 10.2174/1381612828666220903120755 Regina Menezes; Paulo Matafome; Marisa Freitas; María-Teresa García-Conesa. "Updated Information of the Effects of (Poly)phenols against Type-2 Diabetes Mellitus in Humans: Reinforcing the Recommendations for Future Research". Nutrients (2022): https://doi.org/10.3390/nu14173563. 10.3390/nu14173563 Íris Guerreiro; Cíntia Ferreira-Pêgo; Diogo Carregosa; Claudia Nunes dos Santos; Regina Menezes; Ana S Fernandes; João Guilherme Costa. "Polyphenols and Their Metabolites in Renal Diseases: An Overview". Foods (2022): https://www.mdpi.com/2304-8158/11/7/1060. 10.3390/foods11071060 Sofia Ferreira; Ana F. Raimundo; Inês Farrim; Regina Menezes. "Ablation of Kex2 activity enhances proIAPP proteotoxicity in yeast". Journal Biomedical and Biopharmaceutical Research (2022): https://doi.org/10.19277/bbr.19.2.301. 10.19277/bbr.19.2.301 Sofia Ferreira; Rejane G. Tavares; Nuno Saraiva; Regina Menezes; Ana F. Raimundo; Flavio H. Reginatto. "Cecropia pachystachya protection against preproIAPP cytotoxicity is independent of Ca2+ homeostasis: lessons learned using a novel yeast model of preproIAPP-induced Ca2+ intracellular dysregulation". Journal Biomedical and Biopharmaceutical Research 18 2 (2021): 109-109. https://doi.org/10.19277/bbr.18.2.272. 10.19277/bbr.18.2.272 Ana F. Raimundo; Sofia Ferreira; Francisco A. Tomás-Barberán; Claudia N. Santos; Regina Menezes. "Urolithins: Diet-Derived Bioavailable Metabolites to Tackle Diabetes". Nutrients 13 12 (2021): 4285-4285. https://doi.org/10.3390/nu13124285. 10.3390/nu13124285 Cristiana Pereira; Vanda M. Lourenço; Regina Menezes; Carla Brites. "Rice Compounds with Impact on Diabetes Control". Foods 10 9 (2021): 1992-1992. https://doi.org/10.3390/foods10091992. 10.3390/foods10091992 Diogo Carregosa; Sara Mota; Sofia Ferreira; Beatriz Alves-Dias; Natasa Loncarevic-Vasiljkovic; Carolina Lage Crespo; Regina Menezes; Rita Teodoro; Cláudia Nunes dos Santos. "Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms". Nutrients 13 9 (2021): 2940-2940. https://doi.org/10.3390/nu13092940. 10.3390/nu13092940 Rita Rosado-Ramos; Joana Godinho-Pereira; Daniela Marques; Inês Figueira; Tiago Fleming Outeiro; Regina Menezes; Cláudia Nunes dos Santos. "Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation". Molecules (2021): https://doi.org/10.3390/molecules26113353. 10.3390/molecules26113353 João P. Baixinho; José D. Anastácio; Viktoriya Ivasiv; Katarina Cankar; Dirk Bosch; Regina Menezes; Matthew de Roode; et al. "Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots". Molecules 26 9 (2021): 2583-2583. https://doi.org/10.3390/molecules26092583. 10.3390/molecules26092583 Melanie S. Matos; José D. Anastácio; J. William Allwood; Diogo Carregosa; Daniela Marques; Julie Sungurtas; Gordon J. McDougall; et al. "Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory". Nutrients 12 11 (2020): 3547-3547. https://doi.org/10.3390/nu12113547. 10.3390/nu12113547 Pereira, Cristiana; Menezes, Regina; Lourenço, Vanda; Serra, Teresa; Brites, Carla. "Evaluation of Starch Hydrolysis for Glycemic Index Prediction of Rice Varieties". Proceedings 70 1 (2020): 101. http://dx.doi.org/10.3390/foods_2020-07643. 10.3390/foods_2020-07643 Raimundo, Ana F.; Ferreira, Sofia; Farrim, Maria I.; Santos, Cláudia N.; Menezes, Regina. "Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity". Frontiers in Microbiology 11 (2020): http://dx.doi.org/10.3389/fmicb.2020.02035. 10.3389/fmicb.2020.02035 Regina Menezes; Alexandre Foito; Carolina Jardim; Inês Costa; Gonçalo Garcia; Rita Rosado-Ramos; Sabine Freitag; et al. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". Antioxidants 9 9 (2020): 789-789. https://doi.org/10.3390/antiox9090789. 10.3390/antiox9090789 Soczewka, Piotr; Flis, Krzysztof; Tribouillard-Tanvier, Déborah; di Rago, Jean-Paul; Santos, Cláudia N.; Menezes, Regina; Kaminska, Joanna; Zoladek, Teresa. "Flavonoids as Potential Drugs for VPS13-Dependent Rare Neurodegenerative Diseases". Genes 11 7 (2020): 828. http://dx.doi.org/10.3390/genes11070828. 10.3390/genes11070828 Sofia Gravanita Ferreira; Ana Filipa Raimundo; Regina Menezes; Ivo C. Martins. "Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease: two triggers, one disease". NEURAL REGENERATION RESEARCH 16 6 (2020): 1127. http://dx.doi.org/10.4103/1673-5374.300323. 10.4103/1673-5374.300323 Raimundo, Ana F.; Ferreira, Sofia; Martins, Ivo C.; Regina Menezes. "Islet Amyloid Polypeptide: A Partner in Crime With Aß in the Pathology of Alzheimer's Disease". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.00035. Open access • 10.3389/fnmol.2020.00035 Raimundo, Ana F.; Félix, Filipa; Andrade, Rita; García-Conesa, María-Teresa; González-Sarrías, Antonio; Gilsa-Lopes, João; do Ó, Dulce; et al. "Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials". European Journal of Nutrition (2020): http://dx.doi.org/10.1007/s00394-020-02189-1. 10.1007/s00394-020-02189-1 Thole, Vera; Bassard, Jean-Etienne; Ramírez-González, Ricardo; Trick, Martin; Ghasemi Afshar, Bijan; Breitel, Dario; Hill, Lionel; et al. "RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild and cultivated berry fruit species with high content of phenolics". BMC Genomics 20 1 (2019): http://dx.doi.org/10.1186/s12864-019-6183-2. 10.1186/s12864-019-6183-2 Figueiredo-Pereira, Cláudia; Menezes, Regina; Ferreira, Sofia; Santos, Cláudia N; Vieira, Helena L A. "Carbon monoxide released by CORM-A1 prevents yeast cell death via autophagy stimulation". FEMS Yeast Research 19 5 (2019): http://dx.doi.org/10.1093/femsyr/foz051. 10.1093/femsyr/foz051 Nicolai Kallscheuer; Regina Menezes; Alexandre Foito; Marcelo Henriques da Silva; Adelaide Braga; Wijbrand Dekker; David Méndez Sevillano; et al. "Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington’s Disease". Plant Physiology 179 3 (2019): 969-985. https://doi.org/10.1104/pp.18.01074. 10.1104/pp.18.01074 Rosado-Ramos, Rita; Godinho-Pereira, Joana; Figueira, Ines; Jardim, Carolina; Garcia, Goncalo; Menezes, Regina. "Exploring the Benefits of Cellular Models to Uncover Bioactive Polyphenols for Neurodegeneration". Current Pharmaceutical Design 24 19 (2018): 2076-2106. http://dx.doi.org/10.2174/1381612824666180629112148. 10.2174/1381612824666180629112148 dos Santos, Claudia Nunes; Menezes, Regina; Stewart, Derek. "Polyphenols as New Leads in Drug Discovery: Biological Activity and Mechanisms". Current Pharmaceutical Design 24 19 (2018): 2041-2042. http://dx.doi.org/10.2174/138161282419180924094610. 10.2174/138161282419180924094610 Dudnik, Alexey; Almeida, A. Filipa; Andrade, Ricardo; Avila, Barbara; Bañados, Pilar; Barbay, Diane; Bassard, Jean-Etienne; et al. "BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits". Phytochemistry Reviews 17 2 (2017): 291-326. http://dx.doi.org/10.1007/s11101-017-9532-2. 10.1007/s11101-017-9532-2 Menezes, Regina; Rodriguez-Mateos, Ana; Kaltsatou, Antonia; González-Sarrías, Antonio; Greyling, Arno; Giannaki, Christoforos; Andres-Lacueva, Cristina; et al. "Impact of Flavonols on Cardiometabolic Biomarkers: A Meta-Analysis of Randomized Controlled Human Trials to Explore the Role of Inter-Individual Variability". Nutrients 9 2 (2017): 117. http://dx.doi.org/10.3390/nu9020117. 10.3390/nu9020117 Menezes, R.; Pimentel, C.; Silva, A.R.C.; Amaral, C.; Merhej, J.; Devaux, F.; Rodrigues-Pousada, C.. "Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate". Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1860 4 (2017): 472-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013855798&partnerID=MN8TOARS. 10.1016/j.bbagrm.2017.02.001 Figueira, I.; Menezes, R.; Macedo, D.; Costa, I.; dos Santos, C.N.. "Polyphenols beyond barriers: A glimpse into the brain". Current Neuropharmacology 15 4 (2017): 562-594. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019604855&partnerID=MN8TOARS. 10.2174/1570159X14666161026151545 Oliveira, A.V.; Vilaça, R.; Santos, C.N.; Costa, V.; Menezes, R.. "Exploring the power of yeast to model aging and age-related neurodegenerative disorders". Biogerontology 18 1 (2017): 3-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994079430&partnerID=MN8TOARS. 10.1007/s10522-016-9666-4 Jardim, C.; Macedo, D.; Figueira, I.; Dobson, G.; McDougall, G.J.; Stewart, D.; Ferreira, R.B.; Menezes, R.; Santos, C.N.. "(Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways". Journal of Functional Foods 32 (2017): 333-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015044027&partnerID=MN8TOARS. 10.1016/j.jff.2017.03.010 Rzepnikowska, W.; Flis, K.; Muñoz-Braceras, S.; Menezes, R.; Escalante, R.; Zoladek, T.. "Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease". Traffic 18 11 (2017): 711-719. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030177615&partnerID=MN8TOARS. 10.1111/tra.12523 Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://dx.doi.org/10.1080/15548627.2015.1100356. 10.1080/15548627.2015.1100356 Santos, Cláudia Nunes dos; Costa, Inês Sousa; Ferreira, Ricardo Boavida; Figueira, Inês; Macedo, Diana; Menezes, Regina; Pinto, Paula; Tavares, Lucélia. "Metabolitos de frutas vermelhas para um envelhecimento saudável do cérebro (Red fruit metabolites for healthy brain aging)". Revista Brasileira de Ciências do Envelhecimento Humano 12 3 (2015): http://dx.doi.org/10.5335/rbceh.v12i3.6082. 10.5335/rbceh.v12i3.6082 Menezes, Regina; Tenreiro, Sandra; Macedo, Diana; Santos, Claudia; Outeiro, Tiago. "From the baker to the bedside: yeast models of Parkinson's disease". Microbial Cell 2 8 (2015): 262-279. http://dx.doi.org/10.15698/mic2015.08.219. 10.15698/mic2015.08.219 Soraia M. Caetano; Regina Menezes; Catarina Amaral; Claudina Rodrigues-Pousada; Catarina Pimentel. "Repression of the Low Affinity Iron Transporter Gene FET4". Journal of Biological Chemistry 290 30 (2015): 18584-18595. https://doi.org/10.1074%2Fjbc.m114.600742. 10.1074/jbc.M114.600742 Mazzola, D.; Pimentel, C.; Caetano, S.; Amaral, C.; Menezes, R.; Santos, C.N.; Eleutherio, E.; Rodrigues-Pousada, C.. "Inhibition of Yap2 activity by MAPKAP kinase Rck1 affects yeast tolerance to cadmium". FEBS Letters 589 19 (2015): 2841-2849. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941413618&partnerID=MN8TOARS. 10.1016/j.febslet.2015.07.049 Ferreira, R.T.; Menezes, R.; Rodrigues-Pousada, C.. "E4-Ubiquitin ligase Ufd2 stabilizes Yap8 and modulates arsenic stress responses independent of the U-box motif". Biology Open 4 9 (2015): 1122-1131. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982782702&partnerID=MN8TOARS. 10.1242/bio.010405 Pimentel, C.; Caetano, S.M.; Menezes, R.; Figueira, I.; Santos, C.N.; Ferreira, R.B.; Santos, M.A.S.; Rodrigues-Pousada, C.. "Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae". Biochimica et Biophysica Acta - General Subjects 1840 6 (2014): 1977-1986. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897453901&partnerID=MN8TOARS. Published • 10.1016/j.bbagen.2014.01.032 Garcia-Oliveira, A.L.; Benito, C.; Prieto, P.; Menezes, R.; Rodrigues-Pousada, C.; Guedes-Pinto, H.; Martins-Lopes, P.. "Molecular characterization of TaSTOP1 homoeologues and their response to aluminium and proton (H+) toxicity in bread wheat (Triticum aestivum L.)". BMC Plant Biology 13 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883709904&partnerID=MN8TOARS. Published • 10.1186/1471-2229-13-134 Bleoanca, I.; Silva, A.R.C.; Pimentel, C.; Rodrigues-Pousada, C.; Menezes, R.. "Relationship between ethanol and oxidative stress in laboratory and brewing yeast strains". Journal of Bioscience and Bioengineering 116 6 (2013): 697-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886411673&partnerID=MN8TOARS. Published • 10.1016/j.jbiosc.2013.05.037 Pimentel, C.; Vicente, C.; Menezes, R.; Caetano, S.; Carreto, L.; Rodrigues-Pousada, C.. "The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability". PLoS ONE 7 5 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861203729&partnerID=MN8TOARS. 10.1371/journal.pone.0037434 Ferreira, R.T.; Courelas Silva, A.R.; Pimentel, C.; Batista-Nascimento, L.; Rodrigues-Pousada, C.; Menezes, R.. "Arsenic stress elicits cytosolic Ca2+ bursts and Crz1 activation in Saccharomyces cerevisiae". Microbiology (United Kingdom) 158 9 (2012): 2293-2302. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865701454&partnerID=MN8TOARS. Published • 10.1099/mic.0.059170-0 Batista-Nascimento, L.; Pimentel, C.; Menezes, R.; Rodrigues-Pousada, C.. "Iron and neurodegeneration: From cellular homeostasis to disease". Oxidative Medicine and Cellular Longevity (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862293528&partnerID=MN8TOARS. 10.1155/2012/128647 Pimentel, C.; Batista-Nascimento, L.; Rodrigues-Pousada, C.; Menezes, R.. "Oxidative stress in Alzheimer's and Parkinson's diseases: Insights from the yeast Saccharomyces cerevisiae". Oxidative Medicine and Cellular Longevity (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863691708&partnerID=MN8TOARS. 10.1155/2012/132146 Pereira, M.D.; Ksiazek, K.; Menezes, R.. "Oxidative stress in neurodegenerative diseases and ageing". Oxidative Medicine and Cellular Longevity (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84870157188&partnerID=MN8TOARS. 10.1155/2012/796360 Rodrigues-Pousada, C.; Regina Menezes; Pimentel, C.. "The Yap family and its role in stress response". Yeast 27 5 (2010): 245-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952283586&partnerID=MN8TOARS. 10.1002/yea.1752 Pereira, J.; Pimentel, C.; Amaral, C.; Menezes, R.A.; Rodrigues-Pousada, C.. "Yap4 PKA- and GSK3-dependent phosphorylation affects its stability but not its nuclear localization". Yeast 26 12 (2009): 641-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-73649098528&partnerID=MN8TOARS. 10.1002/yea.1711 Menezes, R.; Amaral, C.; Batista-Nascimento, L.; Santos, C.; Ferreira, R.B.; Devaux, F.; Eleutherio, E.C.A.; Rodrigues-Pousada, C.. "Contribution of Yap1 towards Saccharomyces cerevisiae adaptation to arsenic-mediated oxidative stress". Biochemical Journal 414 2 (2008): 301-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-50949128387&partnerID=MN8TOARS. 10.1042/BJ20071537 Rodrigues-Pousada, C.; Nevitt, T.; Menezes, R.. "The yeast stress response: Role of the Yap family of b-ZIP transcription factors. The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw". FEBS Journal 272 11 (2005): 2639-2647. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444492830&partnerID=MN8TOARS. 10.1111/j.1742-4658.2005.04695.x Menezes, R.; Amaral, C.; Delaunay, A.; Toledano, M.; Rodrigues-Pousada, C.. "Yap8p activation in Saccharomyces cerevisiae under arsenic conditions". FEBS Letters 566 1-3 (2004): 141-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442577070&partnerID=MN8TOARS. 10.1016/j.febslet.2004.04.019 Rodrigues-Pousada, C.A.; Nevitt, T.; Menezes, R.; Azevedo, D.; Pereira, J.; Amaral, C.. "Yeast activator proteins and stress response: An overview". FEBS Letters 567 1 (2004): 80-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542442466&partnerID=MN8TOARS. 10.1016/j.febslet.2004.03.119 Menezes, R.; Amuel, C.; Engels, R.; Gengenbacher, U.; Labahn, J.; Hollenberg, C.P.. "Sites for interaction between Gal80p and Gal1p in Kluyveromyces lactis: Structural model of galactokinase based on homology to the GHMP protein family". Journal of Molecular Biology 333 3 (2003): 479-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141862178&partnerID=MN8TOARS. 10.1016/j.jmb.2003.08.034 Vollenbroich, V.; Meyer, J.; Engels, R.; Cardinali, G.; Menezes, R.; Hollenberg, C.P.. "Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p". Molecular and General Genetics 261 3 (1999): 495-507. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032965616&partnerID=MN8TOARS. 10.1007/s004380050993 Da Silva, L.A.F.; Moreira, M.A.M.; Bezerra, J.P.; Tovar, F.J.; Almeida, C.A.S.; Menezes, R.; Leoncini, O.. "Analysis of rDNA variation in the genus Didelphis (Marsupialia)". Revista Brasileira de Genetica 18 1 (1995): 37-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028966730&partnerID=MN8TOARS.
Magazine article	Emilia Borba Alves; Ferreira, Sofia; Farrim, Maria I.; Regina de A. Menezes. "ß-cell Exhaustion and Islet Microenvironment: The Role of Local Vascular Network.", Revista Portuguesa de Diabetes, 2024 Carolina Jardim; Diana Macedo; Inês Figueira; Regina Menezes; Sandra Tenreiro; Tiago F. Outeiro; Ricardo B. Ferreira; Cláudia N. Santos. "MEDRONHO: UM FRUTO COM EFEITOS BENÉFICOS NAS DOENÇAS DEGENERATIVAS (Strawberry tree fruits: beneficial effects for neurodegenerative diseases)", Agrotec, 2014
Thesis / Dissertation	Regina Menezes, Regina A Menezes or Regina de Andrade Menezes. "Interaction between Gal1 and Gal80 in the regulation of galactose metabolism in Kluyveromyces lactis.". PhD, Universidade Federal do Rio de Janeiro, 2002. Regina Menezes, Regina A Menezes or Regina de Andrade Menezes. "rDNA physical mapping of yeast in the genus Metschnikowia.". Master, Universidade Federal do Rio de Janeiro, 1997. Regina Menezes, Regina A Menezes or Regina de Andrade Menezes. "Analysis and comparison of Didelphis albiventris and Didelphis aurita (Marsupialia) rDNA Restriction Patterns". Degree, Universidade Federal do Estado do Rio de Janeiro, 1993.

Other

Other output

Exploring Vegetarian and Omnivorous Approaches to Cardiovascular Risk and Body Composition. Scholarly Community Encyclopedia Video adapted from 10.3390/nu16132013. Nutrition plays a key role in preventing non-communicable diseases, with non-animal-based diets linked to improved body composition and health. In this study, vegetarians show lower LDL and non-HDL cholesterol, yet CVD risk depends more on body fat distribution, underscoring the importance of diet quality and composition.. 2024. Tatiana Fontes; Sofia Lopes; Cíntia Ferreira-Pêgo; Regina Menezes; Marta Esgalhado; Luís Monteiro Rodrigues. https://encyclopedia.pub/video/1424.
Standard Operating Procedure and Risk Assessment Document. The document describes the standard operating procedure (SOP) and the risk assessment protocol prepared by the CEDOC from NOVA Medical School, NOVA University of Lisbon (NMS/CEDOC) with the purpose of assisting the Portuguese community on the diagnosis for Coronavirus disease 2019 (COVID-19).. 2020. Ana Oliveira; Ana Soares; Catarina Pinto; Claudia Nunes dos Santos; Teresa Gomes; Regina Menezes.
Erratum to. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356. 2016. Daniel J. Klionsky; Kotb Abdelmohsen; Akihisa Abe; Md Joynal Abedin; Hagai Abeliovich; Abraham Acevedo Arozena; Hiroaki Adachi; et al. https://research.ulusofona.pt/en/publications/4e367776-94ae-4ca3-aa62-c0a23976622c.
10.1080/15548627.2016.1147886

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/11	Seeking natural compounds for pancreatic ß-cell function in diabetes	V Jornadas CBIOS Universidade Lusófona
2023/10	Health benefits of gut microbiota-derived polyphenol metabolites in the prevention of diabetes: the case of urolithins	X Iberoamerican Congress of Pharmaceutical Sciences (X Congreso Iberoamericano de Ciencias Farmacéuticas) Pharmacy Faculty - Universidade de Coimbra
2023/03	Urolitinas como agentes inibidores da proteotoxicidade do IAPP na diabetes (Urolithins as inhibitors of IAPP proteotoxicity in diabetes)	19º Congresso Português de Diabetes (19th Portuguese Diabetes Congress) (Vilamoura, Portugal)
2022/01	(Poly)phenols as inhibitors of protein aggregation in chronic diseases: the case of Diabetes	Polyphenols as a Therapeutic Option for the Treatment of Diabetes Molecules - MDPI (Virtual, Portugal)
2021/10	Improving body composition to fight diabetes: the power of dietary phytochemicals	LVI Annual Congress of Brazilian Society of Physiology (Virtual, Brazil)
2021/09	Urolithin B protects against diabetes by preventing proteostasis imbalance and oxidative stress	ROS roundabout - many exit options COST Action 16112- NutRedOx (Gdansk, Poland)
2021/07	Modulation of IAPP aggregation and calcium-signaling are key mechanisms underlying Urolithin B protection against amyloidogenesis in diabetes	Physiology 2021 The Physiological Society (Online / Worldwide)
2019/11	IAPP processing as a trigger of intracellular oligomerization in type 2- diabetes	EMBO Workshop Proteostasis: From organelles to organisms (Ericeira, Portugal)
2019/11	Bioativos em mirtilos no combate às doenças crónicas (Blueberry bioactives in the fight against chronic diseases)	9º Encontro Nacional dos Produtores de Mirtilos (9th National Meeting of Blueberry Producers) (Guarda, Portugal)
2017/03	Agregação do IAPP como alvo terapêutico na diabetes: desenvolvimento de modelos celulares com potencial aplicação na identificação de moléculas protetoras (IAPP aggregation as a therapeutic target in diabetes: development of cell models with potential application in the identification of protective molecules)	13º Congresso Português de Diabetes (13th Portuguese Diabetes Congress) (Vilamoura, Portugal)
2016/07	Novel therapeutic (poly)phenols revealed after a berry germplasm bioprospection.	XXVIIIth International Conference on Polyphenols (Viena, Austria)
2015/03	Novas abordagens para o estudo de bioatividades de pequenos frutos (Novel approaches for the study of berry bioactivities).	EU-Berry Final Meeting (Lisbon, Portugal)
2014/11	Recapitulating molecular aspects of human diseases in yeast models of aggregation, cancer and inflammation: bioprospection of potential therapeutic compounds	1st Proteostasis Meeting (COST Action BM1307 ) (Valencia, Spain)
2014/09	Yeast SMART platform for screening of bioactives in human pathologies.	Summer School on Nutrigenomics (Camerino, Italy)
2009/10	Arsenic compounds induce oxidative stress in Saccharomyces cerevisiae	4th International Congress on Stress Response in Biology and Medicine (Japan)
2008/12	Molecular mechanisms of arsenic adaptation: Role of Yap1 and Yap8 in arsenic stress responses	XVI Biochemistry National Congress (Portugal)
2007/12	Role of Yap1 and Yap8 in arsenic stress responses	RNA2007 - IV RNA National Congress (Portugal)
2006/12	Cooperation between YAP1 e o YAP8 in the arsenic stress response of S. cerevisiae	III Meeting of Brazilian Researchers in Portugal (Portugal)
2006/12	Integrating Yap1 and Yap8 in the S. cerevisiae arsenic stress response	XV Biochemistry National Congress (Portugal)
2004/12	Interplay between Yap8p and Yap1p in the acquisition of resistance to the metalloid arsenic	XIV Biochemistry National Congress (Portugal)
2003/09	Yap8p is involved in Arsenic Stress Responses	Ist Luso-Spanish Workshop on the Structure and Function of Proteins (La Coruña, Spain)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/03/01 - Current	RNAs longos não codificantes (lncRNAs) como potenciais biomarcadores associados à falência das células ß pancreáticas no diabetes (Non-coding long RNAs - lncRNAs - as potential biomarkers associated with pancreatic ß-cell failure in diabetes) Supervisor of Ana Catarina Aleixo Mendes	Integrated Master in Pharmaceutical Sciences (Master) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2022/02 - Current	Targeting ß-cell dysfunction as a therapeutic strategy for diabetes: multi-omics approach focused on ß-cell dedifferentiation and a- to ß-cell-like transdifferentiation Supervisor of Maria Inês de Jesus Duarte Farrim	Health Sciences (PhD) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal Universidad de Alcalá, Spain
2021/06 - Current	Targeting IAPP aggregation as a nutritional strategy for diabetes control: focus on protection by urolithins Supervisor of Sofia Gravanita Ferreira	Health Sciences (PhD) Universidad de Alcalá, Spain Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2019/01 - Current	Optimization of low glycemic index rice-based biscuits with potential benefits in diabetes controlling Co-supervisor of Cristiana Lucas Pereira	Agro-Industrial Technologies (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/02 - 2023/07	Targeting IAPP proteotoxicity as a strategy to delay diabetes progression Supervisor of Ana Filipa Raimundo	Bioengenharia (PhD) Instituto de Biologia Experimental e Tecnológica, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/09 - 2021/01	IAPP oligomers as critical entities in diabetes Supervisor of Maria Inês de Jesus Duarte Farrim	Molecular Genetics and Biomedicine (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/07 - 2018/12	Evaluation of the anti-inflammatory activity of Rubus spp polyphenol metabolites Supervisor of Carolina Maria Basto de Lima da Palma Santos	Food Quality and Health (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/09 - 2018/01	Increased levels of Islet Amyloid PolyPeptide - IAPP - as a risk factor for Diabetes Mellitus Supervisor of Filipa Isabel Bernado Félix	Molecular Biology and Genetics (Master) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal
2016/09 - 2017/09	Unraveling phenolics with potential therapeutic application for neurodegeneration Supervisor of Marcela Vaz	Biochemistry for Health (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011/01 - 2015/12	Yeast Response to Arsenic Threats Supervisor of Ana Rita Tomé Ferreira	Biochemistry (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/09 - 2015/11	Role of betalains on neuroprotective effect of Opuntia spp. natural extracts Supervisor of Elena Valeria Girlus	Biochemistry for Health (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/05 - 2012/12	Design of a S. cerevisiae-based process for biodetection and bioremediation of arsenic contaminated water Supervisor of Ana Filipa Nunes Leitão Alegre	Technology and Food Security (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009/09 - 2011/11	Role of the Mediator complex in RNA Polymerase II recruitment by the stress transcription factor Yap8 Supervisor of Ana Rita Ladeira Courelas Silva	Molecular Genetics and Biomedicine (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/09 - 2010/09	The Mediator Complex and the transcriptional activity of Yap1 e Yap8 in yeasts subjected to arsenic stress Supervisor of Joana Ropio	Human Biology and Environment (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/09 - 2023/11	V Jornadas CBIOS (2023/11/10 - 2023/11/10) Symposium (Member of the Organising Committee)	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2023/07 - 2023/07	Outreaching activity: Internship in the framework of "Ciência Viva" (Living Science) initiative, Project "Uma Viagem Ao Mundo Da Química E Da Biologia Para Prevenir A Diabetes" ( Journey into the Chemistry and Biology World to Prevent Diabetes). Target audience - high-school students (2023/07 - 2023/07) Other	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2022/07 - 2022/07	Outreaching activity: Internship in the framework of "Ciência Viva" (Living Science) initiative, Project "Uma Viagem Ao Mundo das Plantas Para Prevenir A Diabetes" ( Journey into the Plant Kindom to Prevent Diabetes). Target audience - high-school students (2022/07 - 2022/07) Other	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2021/07 - 2021/07	Outreaching activity: Internship in the framework of "Ciência Viva" (Living Science) initiative, Project "Uma Viagem Ao Mundo das Plantas Para Prevenir A Diabetes" ( Journey into the Plant Kindom to Prevent Diabetes). Target audience - high-school students (2021/07 - 2021/07) Other	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2020/02 - 2020/02	Outreaching activity: CEDOC Open Day 2020 Doenças Raras (Rare Diseases); target audience - kids and adults (2020/02 - 2020/02) Exhibition (Member of the Organising Committee)	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018/09 - 2018/09	2nd International Conference on Food Bioactives & Health (2018/09 - 2018/09) Congress (Member of the Organising Committee)	Instituto de Biologia Experimental e Tecnológica, Portugal
2017 - 2017	Outreaching activity: ITQB Open Day 2017 Ciência bem medida: medir o mundo do nano ao macro (Well-measured science: measuring the world from nano to macro). Target audience: kids and adults from Oeiras Town Municipality (2017 - 2017) Exhibition (Member of the Organising Committee)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 - 2016	PROTEOSTASIS and its Biological Implications - COST Action Proteostasis (2016 - 2016) Conference (Member of the Organising Committee)	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016 - 2016	V Colóquio Nacional da Produção de Pequenos Frutos (V National Colloquium on Berry Production) (2016 - 2016) Meeting (Co-organisor)	Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2015 - 2015	EUberry National Symposium (2015 - 2015) Symposium (Co-organisor)	Instituto de Biologia Experimental e Tecnológica, Portugal
2008 - 2008	Outreaching activity: ITQB Open Day 2008. Target audience - kids and adults from Oeiras Town Municipality (2008 - 2008) Exhibition (Member of the Organising Committee)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2020/04 - Current	CEDOC –NOVA Medical School COVID-19 Task Force with the purpose of assisting the Portuguese community on the diagnosis for Coronavirus disease 2019 (COVID-19). Other	CEDOC - NOVA Medical School COVID-19 Task Force Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2020/06/01 - 2020/06/02	EASD-NAFLD study group Virtual meeting 2020 - Part II Meeting	EASD-NAFLD study group Virtual meeting 2020 - Part II
2020/05/19 - 2020/05/20	EASD-NAFLD study group Virtual meeting 2020 - Part I Meeting	EASD-NAFLD study group Virtual meeting 2020 - Part I
2020/05/06 - 2020/05/08	EGIR STUDY GROUP Virtual Meeting "Liver-pancreas-gut cross talk and type 2 diabetes” Meeting	EGIR STUDY GROUP Virtual Meeting "Liver-pancreas-gut cross talk and type 2 diabetes”

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/07	Structural and functional studies on Arabidopsis thaliana Diacylglycerol Kinase 4 (Thesis) Main arguer	Samuel Jorge Patrício Oliveira (Other) Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2023/09	Impact of Erucin in kidney cells: a morphometric analysis (Thesis) Main arguer	Ana Marta Santos (Master) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2023/05	Estudo do potencial efeito antitumoral do ácido 4- hidroxi-4-O-sulfato benzóico no carcinoma renal humano (Antitumor effect of 4-hydroxy-4-O-benzoic acid on human renal carcinoma) (Thesis) Main arguer	Pedro Vaz de Almeida Fernandes (Master) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2022/12	Evaluation of the antifungal potential of natural marine compounds (Thesis) Main arguer	Diana Mendes Grilo (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2022/03	Ácido cafeico e acids hidroxicinâmicos: que impacto têm nas células tumorais renais (Caffeic acid and hydroxycinnamic acids: how do they impact kidney tumor cells) (Thesis) Main arguer	Miguel Alexandre Brilhante Camilo (Master) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2022/03	Caracterização de hábitos de compra de suplementos alimentares pela Internet (Characterization of buying habits of food supplements on the Internet) President of the jury	Pedro Duque Malaquias de Lemos (Master) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2022/01	Impacto dos acidos hidroxicinâmicos alimentares na progressão do cancer renal (Impact of dietary hydroxycinnamic acids on kidney cancer progression) (Thesis) Main arguer	Joana Duarte Gabriel (Master) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2022/01	Zap1 is required for Candida glabrata response to fluconazole (Thesis) Main arguer	Gonçalo dos Santos Afonso (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/11	Avaliação da atividade antioxidante de complexos de manganês (II) e sua aplicação para atenuação da toxicidade da alfa-sinucleína (Evaluation of the antioxidant activity of manganese(II) complexes and their application to attenuate alpha-synuclein toxicity) (Thesis) Main arguer	Daniela Dias Queiroz (PhD) Universidade Federal do Estado do Rio de Janeiro, Brazil
2021/09/02	Avaliação da atividade antioxidante de complexos de coordenação contendo os metais de transição ferro, cobre e manganês (Evaluation of the antioxidant activity of coordination complexes containing the transition metals iron, copper and manganese) (Thesis) Main arguer	Larissa Maura de Melo Mattos (Master) Universidade Federal do Rio de Janeiro Instituto de Química, Brazil
2018/11	Optimization of IgG Display in S. cerevisiae (Thesis) Main arguer	Vanessa Isabel Ferreira Veríssimo (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/12	Deciphering novel targets for antifungal drugs: ionic liquids as triggers of alternative pathways for cell wall integrity in filamentous fungi (Thesis) Main arguer	Carlos Jorge da Silva Moreira (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/07	Dealing with copper toxicity: New insights into copper detoxification in yeast (Thesis) Main arguer	Ana Carolina Rodrigues Gaspar Cordeiro (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/04	Triggering secondary metabolite biosynthesis: exploring the effects of ionic liquids in fungal metabolism (Thesis) Arguer	Paula Cristina Alves Marques (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/12	Alpha-synuclein phosphorylation role on Parkinson’s disease (Thesis) Main arguer	Filipa Magalhães Silva (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/11	Research of polyphenols with neuroprotective potential using yeast models (Thesis) Main arguer	Carolina Emanuel Carreira Gomes Jardim (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2010/01	Role of Yap8 and Yap1 b-Zip transcription factors in arsenic stress (Thesis) Arguer	Catarina Sá de Almeida Amaral (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1997/09	BSc degree - Isolation of a cDNA encoding a signalling protein associated with defense mechanisms of A. thaliana against Xanthomonas campestris pv. Campestris (Thesis) Main arguer	Ana Beatriz Uchôa C.M. Pérez (Other) Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde, Brazil
1995/11	BSc degree - Extraction and characterization of HMG type proteins from S. mansoni (Thesis) Main arguer	Fabiana C. Morales (Other) Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde, Brazil
1993/09	BSc degree - Cytogenetic Studies in Geophagus brasiliensis (Perciformes-Cichlidae) from its Type-Location (Rio de Janeiro) (Thesis) Arguer	Carla Carneiro de OIiveira (Other) Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde, Brazil

Association member

	Society Organization name	Role
2021/07 - Current	Sociedade Portuguesa de Fisiologia (Portuguese Physiology Society)	Member
2016/06 - Current	European Association for the Study of Diabetes	Regular member
2016/01 - Current	Sociedade Portuguesa de Diabetologia (Portuguese Diabetes Society); Membro do Grupo de Investigação Fundamental e Translacional - GIFT (Member of the Study Group on Fundamental and Translational Research)	Regular member

Committee member

	Activity description Role	Institution / Organization
2024 - Current	Selection Committee of a Professor/Researcher Position at University of Barcelona Member	Universitat de Barcelona Departament de Bioquímica i Biologia Molecular, Spain
2021/08 - Current	Member of the Management Committee (Portugal representative) of the Collaborative Network "COST Action CA20113 - ProteoCure: A sound proteome for a sound body: targeting proteolysis for proteome remodeling"	European Cooperation in Science and Technology, Belgium
2021/08 - Current	Member of the Scientific Council of CBIOS - Universidade Lusófona Member	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2017/05 - 2020/04	Member of the Management Committee (Portugal representative) of the Collaborative Network "COST Action CA15138 TRANSAUTOPHAGY: European Network of Multidisciplinary Research and Translation of Autophagy knowledge" Member	European Cooperation in Science and Technology, Belgium
2012 - 2017	Member of the Management Committee (Portugal representative) of the Collaborative Network "Biomedicine and Molecular Biosciences COST Action BM1307 PROTEOSTASIS: European network to integrate research on intracellular proteolysis pathways in health and disease" Member	European Cooperation in Science and Technology, Belgium

Conference scientific committee

	Conference name	Conference host
2024/02/01 - Current	IV Jornadas Lusófonas da Nutrição	Universidade Lusófona
2023/09/01 - 2023/11/10	V Jornadas CBIOS	Universidade Lusófona
2022/01 - 2022/04	COST ProteoCure 1st Meeting	COST
2018/09/26 - 2018/09/28	2nd International Conference on Food Bioactives & Health	Instituto de Biologia Experimental e Tecnológica

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2022/02 - Current	Microbiology (Curricular Unit Coordinator)	BSc Nutrition Sciences (Licenciatura)	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2021/09 - Current	Microbiology (Curricular Unit Coordinator)	MSc Pharmaceutical Sciences (Mestrado integrado)	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2021/05 - Current	Invited Lecture Herbal Food Supplements (Curricular unit: Food Supplements)	Master in Health Products and Food Supplements (Mestrado)	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2023/09 - 2024/02	Molecular and Cellular Biology (Integrated Master's Degree in Medicine)	Medicina (Mestrado integrado)	Universidade Nova de Lisboa, Portugal
2023/11 - 2023/11	Invited Lecture Endocrine Diseases (Curricular Unit: Physiopathology/Nutrition Pathology)	Integrated Master in Pharmaceutical Sciences / Degree in Nutrition Sciences	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2023/05 - 2023/05	Invited Lecture Hunger-satiety neuroendocrine metabolism (Curricular units: Human Physiology II and Physiology)	Integrated Master in Pharmaceutical Sciences/Degree in Nutrition Sciences/Degree in Biomedical Engineering	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2023/05 - 2023/05	Invited Lecture Protein aggregation in chronic diseases: the case of diabetes and the protective role of (poly)phenols (Curricular Unit Molecular Basis of Oxidative Stress Responses)	MSc/PhD in Biochemistry	Universidade Federal do Estado do Rio de Janeiro, Brazil
2020/10 - 2022/02	Tissues, cells, and molecules	Integrated Master in Medicine (Mestrado integrado)	Universidade Nova de Lisboa, Portugal
2021/05 - 2021/05	Invited Lecture Regulation of body composition: Metabolism, hunger, satiety (Curricular units: Human Physiology II and Physiology)	Integrated Master in Pharmaceutical Sciences/Degree in Nutrition Sciences/Degree in Biomedical Engineering) (Mestrado integrado)	Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2015 - 2018	Invited Lecture Model Organisms	PhD in Molecular Biosciences (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009 - 2009	Invited Lecture Journal Club in Yeast Stress	PhD in Molecular Biosciences (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008 - 2008	Invited Lecture Reporter Genes of Gene Expression and Protein Localization	PhD Molecular Biosciences (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007 - 2007	Invited Lecture Protein Technologies from bacteria to yeast	PhD Molecular Biosciences (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003 - 2006	Invited Lecture Reporter Genes of Gene Expression and Protein Localization	PhD Molecular Biosciences (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1999 - 1999	Monitor of Practical Sessions - Metabolism in Yeast	BSc Microbiology (Bachelor (1st cycle))	Heinrich-Heine-Universität Düsseldorf, Germany
1999 - 1999	Invited Lecture Galactose Metabolism in Yeasts	BSc Microbiology (Bachelor (1st cycle))	Heinrich-Heine-Universität Düsseldorf, Germany
1996 - 1996	Lecture Gene Therapy	BSc Biological Sciences - Genetics (Licenciatura)	Universidade Federal do Rio de Janeiro, Brazil
1996 - 1996	Lecture Retrovirus and Retrotransposons	BSc Biological Sciences - Genetics (Licenciatura)	Universidade Federal do Rio de Janeiro, Brazil
1996 - 1996	Lecture Chromatin Structure	BSc Biological Sciences - Genetics (Licenciatura)	Universidade Federal do Rio de Janeiro, Brazil
1996 - 1996	Invited Lecture Recombinant DNA Technology	BSc Biological Sciences - Genetics (Licenciatura)	Universidade Federal do Rio de Janeiro, Brazil
1995 - 1995	Lecture Molecular Approaches to Marine Genetics	BSc Biological Sciences - Genetics (Licenciatura)	Universidade Federal do Rio de Janeiro, Brazil

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2024/06 - Current	Guest Editor - Nutrients (Special Issue on Nutritional Modulators of Gut Neuroendocrine Factors)	MDPI, Switzerland	MDPI
2023/09 - Current	Guest Editor - Healthcare MDPI (Special Issue Living with Multimorbidity - From Current Prevention Strategies to Personalized Care)	MDPI, Switzerland	MDPI
2021/08 - Current	Project Reviewer, Program Ideas and PROMIS - Science Fund of the Republic of Serbia Evaluator	Fond za nauku Republike Srbije (Science Fund of the Republic of Serbia), Serbia	Fond za nauku Republike Srbije (Science Fund of the Republic of Serbia)
2021/01 - Current	Guest Editor - Nutrients (Special Issue on Polyphenols for Diabetes)	MDPI, Switzerland	MDPI
2017 - Current	Foreign Member of the Expert Team and Foreign Reviewer: Funding Schemes Uwertura, Opus, Sonata, Preludium and Preludium Bis; National Science Centre - Poland Evaluator	National Science Centre (NCN), Poland	National Science Centre (NCN)
2013 - Current	AD-HOC REFEREE: Trends in Food Sciences, Scientific Reports, PLOSONE, FEBS J., Molecular and Cellular Proteomics, BBA-MCR, J. Agric. Food Chem., Molecular Nutrition and Food Research, Oxidative Medicine and Cellular Longevity, Current Genomics, J. Biotechnology, J. Cell Science, Molecules, Biogerontology, FEMS Yeast Research, Yeast, J. Brewing and Distilling, Advances in Research, CLEAN - Soil, Air, Water, British J. Applied Science & Technology, BBR.
2020 - 2020	Project Reviewer, ERA.Net RUS Plus - RUS_ST2019 call	European Union’s Seventh Framework Programme for Research, Technological Development, Belgium	European Union’s Seventh Framework Programme for Research, Technological Development
2017 - 2017	Project Reviewer/External Expert (surrogate) - Cost Association Other	European Cooperation in Science and Technology, Belgium	European Cooperation in Science and Technology
2017 - 2017	Guest Editor - Current Pharmaceutical Design (Special Issue on Polyphenols as new leads in drug discovery: biological activity and mechanisms)	Bethan Science Publishers, United Arab Emirates
2014 - 2017	Thesis Evaluation Committee (PhD in Biochemistry): Soraia Caetano; Project title - Stress response mechanisms underlying metal detoxification in yeast: the cases of cobalt, cadmium and iron Evaluator	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 - 2015	Thesis Evaluation Committee (PhD in Biochemistry): Diana Constantino Macedo; Project title -Investigating the neuroprotective effect of plant polyphenols in models of Parkinson’s disease	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Instituto de Medicina Molecular, Portugal
2014 - 2014	Project Reviewer/External Expert - Fondo Nacional de Desarrollo Científico y Tecnológico (Fondecyt) Evaluator	Comisión Nacional de Investigación Científica y Tecnológica Fondo Nacional de Desarrollo Científico y Tecnológico, Chile	Comisión Nacional de Investigación Científica y Tecnológica Fondo Nacional de Desarrollo Científico y Tecnológico
2010 - 2013	Thesis Evaluation Committee (PhD in Biology): Ana Margarida Teixeira Saramago; Project title - Innovative Strategies to Combat Foodborne Pathogens: Examining the Role of RNases and Small RNAs	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 - 2012	Guest Editor - Oxidative Medicine and Cellular Longevity (Special Issue on Oxidative Stress in Neurodegenerative Diseases and Ageing)	Hindawi Limited, United Kingdom

Journal scientific committee

	Journal title (ISSN)	Publisher
2023/02 - Current	Biology (Editorial Board Member) (2079-7737)	MDPI

Distinctions

Award

2024	VIVER SAUDÁVEL 2024 Award, Project of the Year - Research for the project MET_BCCV: METabolism, Body Composition and CardioVascular health VIVER SAUDÁVEL , Portugal
2022	7th Edition of Ciência Viva in the Laboratory by All time GABBAS Award (Project Coordinator) GABBAS, Portugal
2016	Nuno Castelo Branco Prize by Portuguese Society of Diabetology for the project "Therapeutics4DM:Towards the elucidation of Islet Amyloid Peptide role in Diabetes Mellitus – opening new venues for therapeutic intervention" Sociedade Portuguesa de Diabetologia, Portugal

Other distinction

2024	STSM for Sofia Ferreira (team member), Project From Bench to Nematode: Exploring Urolithin B's Bioactivity Against IAPP-Induced Pr. Host Inst.: Utrecht University - Supervisor: Tessa Sinnige, Home Inst. CBIOS - Supervisor: Regina Menezes PROTEOCURE COST ACTION, Belgium
2023	Fullbrigth grant to Maria Inês Farrim (team member), Proj.: Integrated Multi-Omics for Novel Diabetes Biomarkers Targeted by (Poly)phenol Metabolites. Host Inst.: UC Davis. Supervisor: Dragan Milenkovic, Home Inst. ULusófona - Supervisor: Regina Menezes Fulbright Portugal, Portugal
2019	Fullbrigth/FCT grant to Ana Filipa Raimundo (team member), Proj.: Amylin oligomers: a link between type-2 diabetes and brain pathology. Host Inst.: U. Kentucky - Supervisor: Florin Despa, Home Inst. iBET - Supervisor: Regina Menezes Fundação para a Ciência e a Tecnologia, Portugal Fullbrigth Portugal, United States
2018	SPD/LILLY grant to attend the "54th EASD Annual Meeting" Swiss Precision Diagnostics GmbH, Switzerland Sociedade Portuguesa de Diabetologia, Portugal
2018	STSM, Project: Impact of IAPP on NFkB activity and the protective activity of phenolic compounds in diabetic processes. Host Inst.: University os Saarland, Medical Biochemistry and Molecular Biology, Germany - Advisor: Gerald Thiele
2018	Erasmus+ Staff Mobility Grant (EU) for Intrabodies technology training - Rome, Italy
2018	SPD/LILLY grant to Ana Filipa Raimundo (as a team member) to attend the "54th EASD Annual Meeting" Swiss Precision Diagnostics GmbH, Switzerland Sociedade Portuguesa de Diabetologia, Portugal
2018	STSM for K. Flis, Project: Yeast as a screening platform to identify biocompounds with putative therapeutic potential in chorea- acanthocytosis (ChAc). Host Institution: iBET - Supervisor: R. Menezes
2017	STSM for Ana Filipa Raimundo (team member), Project: Human IAPP aggregation in pancreatic beta cells. Host Inst.: Nestlé Institute of Health Sciences - Supervisor: El Hadji Dioum, Home Inst. iBET - Supervisor: Regina Menezes
2017	SPD/LILLY grant to attend the "53rd Annual Meeting of EASD - EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES Swiss Precision Diagnostics GmbH, Switzerland
2016	Erasmus+ Staff Mobility Grant (EU) for Yeast Metabolomics training - Dundee, Scotland
2014	Post-Doctoral Fellowship in the framework of the EU project BacHBerry FP7-KBBE-2013-613793 European Commission, Belgium
2013	Post-Doctoral Fellowship in the framework of an internal project of the Disease and Stress Biology Laboratory
2009	Grant to attend the "4th International Congress on Stress Response in Biology and Medicine" in Sapporo, Japan
2008	Grant to attend the "XI Congress of Pan-American Society of Biochemistry and Molecular Biology (PABMB)" in Águas de Lindoia, Brazil
2008	Grant to attend the "EMBO WORKSHOP – Gene Transcription in Yeast" in Girona, Spain
2007	Grant to attend the "XXIII International Conference on Yeast Genetics and Molecular Biology” in Melbourne, Australia Florida Communications Group, United States
2007	Grant to attend the "Gordon Research Conferences: Stress Proteins in Growth , Development and Disease" in Oxford, UK
2006	Grant to attend the "XV Congresso Nacional de Bioquímica" in Aveiro, Portugal
2006	Pos-Doctoral Fellowship Fundação para a Ciência e a Tecnologia, Portugal
2004	Grant to attend the "Forum for Young Scientists" in Warsaw, Poland
2004	Grant to attend the "29th FEBS Congress" in Warsaw, Poland
2004	Grant to attend the "XIV Congresso Nacional de Bioquímica" in Vila Moura, Portugal Health Canada Strategic Policy Branch, Canada
2003	Post-Doctoral Fellowship Fundação para a Ciência e a Tecnologia, Portugal
2000	PhD Fellowship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
1997	PhD Fellowship Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
1997	PhD Fellowship Deutscher Akademischer Austauschdienst, Germany
1996	"UFRJ Scientific Initiation Symposium UFRJ" - Prize for the work entiltled “Amplificação de Longos Fragmentos de DNA Ribossômico em Leveduras” (Amplification of large fragments of ribosomal DNA in yeast)
1994	Master Fellowship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
1993	Scientific Initiation Fellowship (BIC) Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil