Identification
Personal identification
- Full name
- Magda Matos Santana
Citation names
- Santana, Magda M
- Santana MM
- Santana M
- Magda M Santana
Author identifiers
- Ciência ID
- 3E17-9ED3-1C8D
- ORCID iD
- 0000-0003-4076-7516
Email addresses
- mmsantana@uc.pt (Professional)
- magda.santana@cnc.uc.pt (Professional)
Websites
- https://cibb.uc.pt/research/innovative-therapies/vectors-gene-cell-therapy/ (Professional)
- https://cnc.uc.pt/en/research-group/gene-and-stem-cell-therapies-for-the-brain (Professional)
Knowledge fields
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
- Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
French | Beginner (A1) | Intermediate (B1) | Beginner (A1) | Beginner (A1) | |
Spanish; Castilian | Beginner (A1) | Intermediate (B1) | Beginner (A1) | ||
English | Intermediate (B1) | Intermediate (B1) | Intermediate (B1) | Intermediate (B1) |
Education
Degree | Classification | |
---|---|---|
2023/04
Concluded
|
COURSE: Summer School in Personalized Medicine - Multimodel Biomarkers and Diagnostics (Outros)
European Infrastructure for Translational Medicine, Netherlands
|
|
2013 - 2018
Concluded
|
Post-doctoral Fellow (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2016/07
Concluded
|
COURSE: From Next Generation Sequencing to Translational Medicine in Neurological Disease Research (Outros)
Universitatsklinikum Tübingen Institut für Medizinische Genetik und angewandte Genomik, Germany
|
|
2016/06/10
Concluded
|
TRAINING: iPSC derivation and differentiation techniques (Outros)
Université du Luxembourg Luxembourg Centre for Systems Biomedicine, Luxembourg
|
|
2016
Concluded
|
COURSE: Statistics applied to laboratories (Outros)
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
|
|
2013/12
Concluded
|
CERTIFICATION: Investigator-Coordinator for animal experimentation (Outros)
Direção-Geral de Alimentação e Veterinária, Portugal
|
|
2013/10/04
Concluded
|
COURSE: Laboratory Animal Science - FELASA C (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2008/10/01 - 2013/07/26
Concluded
|
Pharmacy (Pharmacology and Pharmacotherapy) (Doutoramento)
Major in Farmacologia e Farmacoterapia
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
Louvor e distinção |
2010/12/09
Concluded
|
COURSE: Advanced course "The complex world of RNA" (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2010/05/21
Concluded
|
COURSE: Advanced Course in Real-time PCR (Outros)
TATAA Biocenter, Sweden
|
|
2009/10/02
Concluded
|
COURSE: Advanced course "Biostatistics" - PDBEB Programme (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2009
Concluded
|
PhD Student - Internship - Neuroendocrinology (Outros)
Technische Universität Dresden, Germany
Universitätsklinikum Carl Gustav Carus, Germany |
|
2002/10 - 2008/07
Concluded
|
Pharmaceutical Sciences (Mestrado integrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
17/20 |
2007
Concluded
|
ERASMUS Program: Undergraduate training in Pharmaceutical Sciences (Outros)
University College London Department of Pharmaceutical and Biological Chemistry, United Kingdom
|
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2019/01/15 - Current | Contracted Researcher (Research) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Positions / Appointments
Category Host institution |
Employer | |
---|---|---|
2017 - Current | Coordinator of human ESMI biobank | European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative, Germany |
2018/08/01 - 2022/07/31 | Coordination support to Master in Pharmaceutical Tecnology | Universidade de Coimbra Faculdade de Farmácia, Portugal |
Universidade de Coimbra Faculdade de Farmácia, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2023/09/01 - 2026/08/31 | NEURODIET - Molecular Mechanisms of Dietary Intervention on Neurodegeneration (PT001)
JPND/0001/2022
Universidade de Coimbra, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023/03 - 2024/08 | Conversão Directa de Astrócitos em Neurónios Cerebelares como tratamento Inovador para a Ataxia Espinocerebelosa do Tipo-3
Provided by PTCRIS: 2022.06127.PTDC
|
Fundação para a Ciência e a Tecnologia |
2023/03 - 2024/08 | Descoberta de biomarcadores da "clínica para o laboratório": a caminho de um ensaio clínico para a doença de Machado-Joseph
Provided by PTCRIS: 2022.06118.PTDC
|
Fundação para a Ciência e a Tecnologia |
2022/01 - 2023/06 | Edição genómica para tratamento da doença de Machado-Joseph por splicing alternativo
Provided by PTCRIS: EXPL/MED-NEU/0936/2021
|
Fundação para a Ciência e a Tecnologia |
2016/05 - 2020/03 | Iniciativa Europeia para a doença de Machado-Joseph / Ataxia Espinocerebelosa do tipo 3
Provided by PTCRIS: JPCOFUND/0001/2015
|
Fundação para a Ciência e a Tecnologia |
2016/04 - 2020/03 | Modelos avançados de doenças de poliglutaminas
Provided by PTCRIS: JPCOFUND/0005/2015
|
Fundação para a Ciência e a Tecnologia |
2008/10 - 2012/09 | CROSSTALK BETWEEN ADIPOCYTES AND ADRENAL GLAND CELLS: INFLUENCE OF OBESITY ON ADRENAL CELL DIFFERENTIATION AND FUNCTION
Provided by PTCRIS: SFRH/BD/44664/2008
|
Fundação para a Ciência e a Tecnologia |
Contract
Designation | Funders | |
---|---|---|
2021/01/01 - 2025/12/31 | Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
Universidade de Coimbra, Portugal
Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023/03/01 - 2024/08/31 | Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3
2022.06127.PTDC
Universidade de Coimbra, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2019/01/01 - 2019/12/31 | CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
2011/03/01 - 2014/08/31 | iCALP - Identificação das funções fisiológicas das calpaínas no controlo da proliferação e migração celulares no sistema nervoso
central
PTDC/SAU-NMC/112183/2009
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2011/01/01 - 2012/12/31 | Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Other
Designation | Funders | |
---|---|---|
2023/03/01 - Current | From bedside-to-bench” biomarker discovery: on the road to a clinical trial for Machado-Joseph Disease
2022.06118.PTDC
Principal investigator
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023/03/01 - Current | AstroIN2Neurons – Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia
Type-3
2022.06127.PTDC
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2022/08/01 - Current | Machado-Joseph Disease iPSC Cell Models for Medium Throughput Drug Screening
--
Researcher
|
Les Laboratoires Servier SAS
Ongoing
|
2022/07/01 - Current | BDforMJD - Biomarker development for Machado-Joseph Disease
CENTRO-01-0145-FEDER-181240
Principal investigator
|
European Regional Development Fund
Ongoing
|
2022/07/01 - Current | ModelPolyQ 2.0 - Advanced Animal Models for Polyglutamine Diseases 2.0
CENTRO-01-0145-FEDER-181258
Researcher
|
European Regional Development Fund
Ongoing
|
2022/07/01 - Current | Gene editing systems for the ATXN3 gene: a therapy for Machado-Joseph disease
CENTRO-01-0145-FEDER-181266
Researcher
|
European Regional Development Fund
Ongoing
|
2022/01/01 - Current | Genome editing to rescue Machado-Joseph disease by alternative splicing
EXPL/MED-NEU/0936/2021
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2020/01/01 - Current | Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2020/01 - 2022/12 | Characterization of iPSCs and YAC mouse model of Machado-Joseph Disease
-
Researcher
|
F Hoffmann-La Roche AG
Concluded
|
2017/02/01 - 2022/03/31 | Viravector - Infrastructure of the national roadmap for production and research with viral vectors
CENTRO-01-0145-FEDER-022095
Researcher
|
European Regional Development Fund
Concluded
|
2019 - 2021 | A systems approach to find a blood-based biomarker for Machado-Joseph Disease
SCA Young Investigator Award
Principal investigator
|
National Ataxia Foundation
Concluded
|
2017/01/01 - 2020/12/31 | BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Post-doc Fellow
|
European Regional Development Fund
Concluded
|
2016/04/01 - 2020/05/31 | ModelPolyQ - Advanced models of polyglutamine disorders (Huntington's disease, SCA3 and SCA7)
Researcher
|
EU Joint Programme Neurodegenerative Disease Research
Concluded
|
2016/01/01 - 2020/05/29 | ESMI - European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
Researcher
|
EU Joint Programme Neurodegenerative Disease Research
Concluded
|
2019 - 2020 | JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
JPCOFUND/0001/2015-ESMI
|
|
2013/04 - 2015/09 | Aging, Stress And Chronic Diseases: From Mechanisms to Therapeutics
CENTRO-07-ST24-FEDER-002006
Post-doc Fellow
|
FEDER (QREN), through Programa Mais Centro
Concluded
|
2015 - 2015 | Caballeta@CNC-Study 3
---
Post-doc Fellow
|
BioBlast Pharma
Concluded
|
2011/03 - 2014/08 | iCALP - Identification of the physiological roles of calpains in the control of cell proliferation and migration in the central
nervous system
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2014 - 2014 | Caballeta@CNC-Study 2
----
Other
|
BioBlast Pharma
Concluded
|
2014 - 2014 | Caballeta@CNC-Study 1
-------
Post-doc Fellow
|
BioBlast Pharma
Concluded
|
2013/08 - 2013/12 | Preclinical study in an animal model of depression
------
Post-doc Fellow
|
Grupo Tecnimede
Concluded
|
2010/04 - 2013/07 | Effect of caffeine and adenosine A2A receptors on stress response: role of adrenal gland modulation
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2010 - 2013 | Caloric restriction increases lifespan: role of NPY on autophagy
PTDC/SAU-FCF/099082/2008
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2010/02 - 2012/09 | The Neuropeptide Y (NPY) and Dipeptidyl-peptidase IV (DPPIV) as new promising targets on the adipose tissue regulation in
obesity
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P. |
2007/05 - 2010/11 | Neuropeptide Y in the retina: Why? What for?
Research Fellow
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2009 - 2009 | The Neuropeptide Y as a promising target on the adipose tissue regulation
n/a
Research Fellow
|
Portuguese Society of Endocrinology, Diabetes and Metabolism (SPEDM) Abbott Laboratórios Lda Concluded
|
Outputs
Publications
Book chapter |
|
Conference abstract |
|
Conference paper |
|
Conference poster |
|
Journal article |
|
Manual |
|
Newspaper article |
|
Preprint |
|
Thesis / Dissertation |
|
Other
Other output |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2022/11/17 | Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair. | 26th Annual Portuguese Society of Human Genetics Meeting
Portuguese Society of Human Genetics (Coimbra, Portugal)
|
2022/11 | ATXN3 alternative splicing in spinocerebellar ataxia type 3/Machado-Joseph disease: diversity and abundance of transcripts in the cerebellum and blood | 26th Annual Meeting of the Portuguese Society of Human Genetics
Portuguese Society of Human Genetics
|
2022/02/10 | Medication patterns of Machado-Joseph disease patients enrolled in the ESMI cohort: a retrospective study | LII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
|
2022/02 | Correction of ATXN3-CAG expansion in MJD patient-derived iPSC by CRISPR/Cas9 homology-directed repair. | LII Portuguese Society of Pharmacology Meeting
Portuguese Society of Pharmacology (Porto, Portugal)
|
2021/02/19 | Phenotypic characterization of neuronal cultures derived from Machado Joseph-Disease induced pluripotent stem cells. | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/19 | Phenotypic characterization of a relevant model of Machado-Joseph disease: the YAC-MJD mouse model | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/19 | European Spinocerebellar Ataxia type 3/ Machado-Joseph Disease initiative: clinical overview of the Coimbra's cohort | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/18 | Brain micrornas in plasma-derived extracellular vesicles as potential biomarkers for Machado-Joseph Disease. | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/18 | Identification of dysregulated mirnas in human induced pluripotent stem cell-based models of Machado-Joseph Disease: one step closer to a therapeutic approach? | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2019/12 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain disorders | 1st Annual Meeting in Pharmaceutical Sciences
(Coimbra, Portugal)
|
2019/11 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases | 5th GEIVEX Symposium
(Granada, Spain)
|
2019/11 | miRNA expression profile of plasma-derived extracellular vesicles distinguishes Machado-Joseph Disease patients from controls | 23rd Annual Meeting, Portuguese Society of Human Genetics
(Coimbra, Portugal)
|
2019/05 | Characterization and follow-up of the Coimbra cohort of Machado-Joseph Disease Patients | 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
(Coimbra, Portugal)
|
2019/05 | A miRNA-based gene therapy approach to knock-down mutant ATXN3: alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration | 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
(Coimbra, Portugal)
|
2019/03 | Serum neurofilaments in SCA3. 1st SCA Global Conference, Wilke C et al. "on behalf of ESMI Consortium" | 1st SCA Global Conference,
(las vegas, United States)
|
2019/02 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases | XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
(Porto, Portugal)
|
2019/02 | Characterization of a trial-ready cohort of Machado-Joseph disease patients: status update | XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
(Porto, Portugal)
|
2019 | Blood biomarker quantification in SCA3 samples. 1st SCA Global Conference, Garcia-Moreno H et al. "on behalf of ESMI consortium" | 1st SCA Global Conference,
(las vegas, United States)
|
2019 | Blood biomarker quantification in SCA3 samples using the Neurology 4-PLEX A kit and the Simoa technology. International Ataxia Research Conference (IARC), Garcia-Moreno H et al. "on behalf of ESMI Consortium" | International Ataxia Research Conference (IARC) |
2019 | European Spinocerebellar Ataxia Type 3/Machado- Joseph Disease Initiative (ESMI). JPco-fuND symposium, Klockgether T. "on behalf of ESMI Consortium" | |
2018/05 | ESMI Biomarkers studies: status and research plan | 3rd JPND-ESMI meeting
ESMI consortium (Ponta Delgada, Azores, Portugal)
|
2018/05 | Non-invasive brain delivery with hybrid extracellular vesicles (EVs) for therapy of Machado-Joseph disease (MJD) | International Society for Extracellular Vesicles Annual Meeting
(Barcelona, Spain)
|
2018/02 | Hybrid vesicles: a promising therapeutic approach for Machado-Joseph disease. | 1st Meeting on Vesicle Biology
(Coimbra, Portugal)
|
2018/02 | Generation of a Machado-Joseph disease isogenic control induced pluripotent stem cell line | XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia clínica, XVII Reunião de toxicologia
(Lisboa, Portugal)
|
2018/02 | Characterization of a trial-ready cohort of Machado-Joseph disease patients | XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia clínica, XVII Reunião de toxicologia
(Lisboa, Portugal)
|
2018/02 | Non-invasive and allele specific gene silencing therapy for Machado Joseph disease and a biomaker to monitor the therapeutic response | XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia clínica, XVII Reunião de toxicologia
(Lisboa, Portugal)
|
2018/01 | Exosomes: tiny vesicles with great potential for MJD treatment | XII Spanish-Portuguese Conference on Controlled Drug Delivery.
(Coimbra, Portugal)
|
2017/07 | Generation of iPSCs for Machado Joseph Disease/Spinocerebellar ataxia type 3 | 2nd JPND-ModelPolyQ meeting
(Strasbourg, France)
|
2017/05 | Workpackge 4 – Biomarkers for Machado Joseph-disease | 2nd JPND-ESMI meeting
(Coimbra, Portugal)
|
2017/05 | Non-invasive silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease | Congresso Nacional da Sociedade Portuguesa de Neurociências (SPN)
(Braga, Portugal)
|
2017/04 | Silencing Spinocerebellar Ataxia Type 3 trough the systemic route | Congresso Nacional da Sociedade Portuguesa das Doenças do Movimento (SPDMov)
(Ofir, Portugal)
|
2017/02 | Silencing MJD trough the systemic route | XLVII Reunião da Sociedade Portuguesa de Farmacologia, XXXV Reunião de Farmacologia clínica, XVI Reunião de toxicologia
(Coimbra, Portugal)
|
2016/11 | Non-invasive and viral-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease | 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana (SPGH)
(Coimbra, Portugal)
|
2016/03 | Trehalose reverses the phenotype of Machado-Joseph disease models | 10th World Congress on Controversies in Neurology (CONy)
(Lisboa, Portugal)
|
2016/02 | Trehalose reverses disease phenotype in both in vitro and in vivo models of Machado-Joseph disease transgenic mice | XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
(Porto, Portugal)
|
2016/02 | Silencing Machado-Joseph disease/Spinocerebellar ataxia type 3 through the systemic route | XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
(Porto, Portugal)
|
2016/02 | The role of NPY on the hypothalamic circadian clock genes | XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
(Porto, Portugal)
|
2014/02 | Role of chromaffin progenitor cells on adrenal medulla response to stress | XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXII Reunião anual de Farmacologia Clínica e XIII Reunião de
Toxicologia
(Coimbra, Portugal)
|
2013/02 | Chronic unpredictable stress, as a model of depression, induces changes in mouse adrenal gland | XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião anual de Farmacologia Clínica e XII Reunião de Toxicologia
(Porto, Portugal)
|
2012/12 | Chromaffin progenitor cells: Isolation, characterization, differentiation and putative role on adrenal medulla adaptation to stress | X CNC meeting
(Coimbra, Portugal)
|
2012/09 | Chronic unpredictable stress induces catecholaminergic system changes in mouse adrenal gland | X International Catecholamine Symposium
(Pacific Grove, CA, United States)
|
2012/02 | Characterization and differentiation of progenitor cells from normal adult human adrenal medulla | XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXX Reunião anual de Farmacologia Clínica e XI Reunião de Toxicologia
(Lisboa, Portugal)
|
2011/02 | Adenosine A1 and A2A receptors in mouse adrenal gland: localization and catecholamine release modulation | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | Hypoxia has dual effects on adipocyte differentiation: relevance on obesity | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | Gliptins inhibit lipid accumulation in a murine pre-adipocyte cell line | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | Hypothalamic progenitor cells differentiate into functional neurons | ) XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | ß-adrenergic receptors activation in human adrenal chromaffin cells: role on catecholamines release | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2010/12 | Modulation of Neuropeptide Y in the adult hypothalamus and hypothalamic neurospheres – role on feeding behavior | VIII CNC Meeting
(Coimbra, Portugal)
|
2010/11 | Does the hypoxia-mimetic agent, CoCl2, have a dual effect on adipogenesis | 1 st International Diabetes and Obesity Forum
(Atenas, Greece)
|
2010/11 | The role of selective inhibitor dipeptidyl-peptidase IV (DPPIV) on the adipogenesis of 3T3-L1 pre-adipocyte murine cell line | 14º Congresso Português de Obesidade
(Coimbra, Portugal)
|
2010/05 | The role of hypoxia on pre-adipocyte proliferation and adipocyte differentiation | Survival or Death as a Matter of Fat
(Coimbra, Portugal)
|
2010/01 | NPY plays na important role in adipose tissue formation regulating adipocytes proliferation and differentiation through different mechanisms | Neuronal Control of Appetite, Metabolism and Weight
(Keystone, Colorado, United States)
|
2009/12 | Isolation and characterization of progenitor cells from normal adult human adrenal medulla | ) XL Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVIII Reunião anual de Farmacologia Clínica e IX Reunião de Toxicologia
(Porto, Portugal)
|
2009/10 | Dipeptidylpeptidase IV (DPPIV) stimulates the proliferation and differentiation of 3T3L1 preadipocyte murine cell line | Obesity 2009 - 27th Annual Scientific Meeting of the Obesity Society
(Washington DC, United States)
|
2009/01 | The increase of pre-adipocyte proliferation induced by dipeptidyl-peptidase IV (DPPIV) is inhibited by vildagliptine | Encontro Nacional da Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolism
(Vilamoura, Portugal)
|
2009 | The neuropeptide Y cleaved by dipeptidylpeptidase IV (DPPIV) producing endogenous NPY Y2 agonist, induces preadipocytes proliferation and differentiation | XL Reunião da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2020/10/18 - 2021/08/01 | Tackling CANcer STEM CELLs: a challenge and an opportunity to advance in anti-cancer therapy
Co-supervisor of Diana Cristina Antunes Candeias Adão
|
|
2018/06/01 - 2021/03/01 | BrainHealth 2020 : Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
Supervisor of Patricia Alexandra Rosado Albuquerque
|
|
2020 - 2021 | The Role of The Immune System in Polyglutamine Diseases
Supervisor of Isa Morais Penas
|
Master in Pharmaceutical Biotechnology
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2020 - 2021 | Machado-Joseph Disease Comorbidities and Symptomatic Treatments: a large cohort analysis
Supervisor
|
Master in Pharmaceutical Biotechnology
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019 - 2020/12 | Brain-enriched plasma-derived extracellular vesicles as biomarkers for Machado-Joseph disease
Supervisor of Maria Manuel Martins Pinto
|
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019/11/19 - 2020/09/30 | BrainHealth 2020 : Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
Co-supervisor of Kevin Costa Leandro
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
2019 - 2020 | Phenotypic characterization of cellular and animal models of Machado-Joseph disease
Supervisor
|
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2017/03 - 2017/07 | Characterization of healthy controls and MJD patient's derived induced pluripotent stem cells (iPSc)
Co-supervisor of Rachele di Donato
|
Medical, Veterinary and Pharmaceutical Biotechnology (Master)
Università degli Studi del Sannio, Italy
Università degli Studi di Foggia, Italy |
2016/01 - 2016/07 | Clarifying the Mechanism of Action of Trehalose on Alleviating Machado-Joseph Disease
Co-supervisor of Allyson Trèvino
|
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
|
2015/05 - 2015/07 | Estudos pré-clínicos em modelos animais com a doença de Machado-Joseph
Supervisor of Patrícia Ines Pires dos Santos
|
Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2018 - Current | Rare diseases day@CNC (2018/02/28) | |
2020 - 2020 | Machado-Joseph Disease: From Laboratory to Society - Rare Disease Day 2020, Centre for Neuroscience and Cell Biology. Coimbra,
Portugal. February 2020. (2020/02/28)
Meeting (Co-organisor)
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2017/05/22 - 2017/05/23 | 2nd JPND ESMI meeting. CNC, May 22-23, Coimbra, Portugal. 2017 (2017 - 2017)
Meeting (Co-organisor)
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2016 - 2016 | 1st Symposium on aging research. CNC. Sep 30, Coimbra, Portugal. 2016 (2016 - 2016) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2016 - 2016 | 1st JPND ModelPolyQ meeting. CNC, Jul 4-5, Coimbra, Portugal. 2016 (2016 - 2016)
Meeting
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2016 - 2016 | 1st International Symposium Brain Without Borders. November 18-19, Coimbra, Portugal. 2016 (2016 - 2016)
Symposium (Member of the Organising Committee)
|
Event participation
Activity description Type of event |
Event name Institution / Organization |
|
---|---|---|
2018 - Current | European Researchers' Night 2018 | European Researchers' Night 2018 |
2018 - Current | Brain Awareness Week |
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2022/09/01 | CHARACTERIZATION OF THE GENETIC PROFILE OF PATIENTS WITH FRONTOTEMPORAL LOBAR DEGENERATION AND ESTABLISHMENT OF THEIR FIBROBLAST
CELL LINES
(Thesis) Main arguer
|
António Miguel Mira Nunes (Master) |
2022/09 | EXTRACELLULAR VESICLES: FROM BRAIN COMMUNICATION TO THERAPEUTIC DELIVERY
(Thesis) Arguer
|
António David Rufino Ramos (PhD) |
2019/09 | A DIFFERENT PERSPECTIVE OF CIRCULATORY BIOMARKERS IN NEURODEGENERATIVE DISEASES: FOCUS ON SERUM HIGH MOLECULAR WEIGHT FRACTION
(Thesis) Main arguer
|
Miguel Maria Varandas Anão Rosado (Master) |
2019/09 | CERVICAL CANCER SCREENING: SELFSAMPLING AS A COMPLEMENT TO THE CONVENTIONAL METHOD
(Thesis) Main arguer
|
Sara da Graça Marques Pereira (Master) |
2019/08 | THE ROLE OF AGEING IN POLYGLUTAMINE INDUCED NEURODEGENERATION. A STUDY IN MACHADO-JOSEPH DISEASE MODELS
(Thesis) Arguer
|
Dina Maria da Silva Rodrigues Pereira (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
|
2019 | CERVICAL CANCER SCREENING: SELF-SAMPLING AS A COMPLEMENT TO THE CONVENTIONAL METHOD | Sara da Graça Marques Pereira (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019 | A DIFFERENT PERSPECTIVE OF CIRCULATORY BIOMARKERS IN NEURODEGENERATIVE DISEASES: FOCUS ON SERUM HIGH MOLECULAR WEIGHT FRACTION | Miguel Maria Varandas Anão Rosado (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019 | HISTOLOGICAL AND MORPHOLOGICAL ANALYSIS OF DEVELOPING NEURONAL PRECURSORS DERIVED FROM HUMAN IPS CELLS
(Thesis) Main arguer
|
Daniela Catarina Gaspar Santos (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
|
2015/09/29 | NOVOS SISTEMAS PARA PENETRAÇÃO DA BARREIRA HEMATOENCEFÁLICA: DAS MICROBOLHAS À FOCAGEM DE ULTRASSONS
(Thesis) Main arguer
|
Luís Miguel Lopes Martinho (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
Ad Hoc journal article review
Journal title (ISSN) | Publisher | |
---|---|---|
2023 - 2023 | Human Molecular Genetics | |
2022 - 2022 | Frontiers in Neuroscience | |
2022 - 2022 | Biomedicines |
Association member
Society Organization name | Role | |
---|---|---|
2020/10/19 - Current | SCA Global Young Investigator Initiative - http://ataxia-global-initiative.net/young-investigator-initiative-yii/yii/ | Founder member - in collaboration with Jennifer Faber and Heike Jacobi |
2018/04/02 - Current | SCA Global Initiative - http://ataxia-global-initiative.net/sca-global/ | Member |
2018/01/01 - Current | Neurosciences Portuguese Society |
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2019/04/22 - Current | Biomarkers in drug development | Drug development Course - PhD Programme in Experimental Biology and Biomedicine | |
2022/11/02 - 2022/11/02 | "Induced pluripotent stem cells for brain disease modelling." invited lecture in Workshop in Viral Vectors and induced pluripotent stem cells for the central nervous system. | Portuguese Glial Network, Portugal | |
2019 - 2020 | Pharmacological screening | Farmácia Biomédica (Licenciatura) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2019 - 2020 | Pre-clinical drug development | Farmácia Biomédica (Licenciatura) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2019/11/13 - 2019/11/13 | Curso Ataxias hereditárias e paraparésias espásticas: da biologia molecular ao tratamento | (Outros) | |
2018/05/08 - 2018/05/08 | Biomarkers | PhD Programme in Experimental Biology and Biomedicine - CNC (Doutoramento) | Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal |
2018/04/28 - 2018/04/28 | Induced Pluripotent Stem Cells: biobank and disease modelling | Biotecnologia Farmacêutica (Mestrado integrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2017/06/09 - 2017/06/09 | Biomarcadores em doença neurodegenerativa: oportunidades e dificuldades | Farmacologia Aplicada (Mestrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2017/04/08 - 2017/04/08 | Induced Pluripotent Stem Cells: biobank and disease modelling | Biotecnologia Farmacêutica (Mestrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2016/12/06 - 2016/12/06 | Genetic aproaches to fight neurodegenerative diseases | Neurociências | Instituto de Medicina Molecular João Lobo Antunes, Portugal |
2016/06/25 - 2016/06/25 | Elaboração de um plano de estudo em ensaios pré-clínicos | Farmacologia Aplicada (Mestrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2013 - 2014 | Human anatomy and physiology | Ciências Farmacêuticas (Mestrado integrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2010 - 2013 | Histologia e Embriologia Humana | Ciências Farmacêuticas (Mestrado integrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2011 - 2011/01/31 | Stem cells in adult adrenal medulla…or not? | PhD Programme in Experimental Biology and Biomedicine - CNC, Coimbra | Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal |
2009 - 2010 | Screening Farmacológico | Farmácia Biomédica (Licenciatura) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
Evaluation committee
Activity description Role |
Institution / Organization | Funding entity | |
---|---|---|---|
2019 - Current | National Ataxia Foundation - Evaluation panel of Scientific calls |
Interview (newspaper / magazine)
Activity description | Newspaper / Forum | |
---|---|---|
2019/11/14 | Entrevista no âmbito do curso "Ataxias hereditárias e paraparésias espásticas: da biologia molecular ao tratamento", no Congresso de Neurologia 2019. | Correio SPN |
Other jury / evaluation
Activity description | Institution / Organization | |
---|---|---|
2022/09/23 - 2022/09/23 | PhD project defense - PhD program in Pharmaceutical Sciences Faculty of Pharmacy of the University of Coimbra; PhD Student: Bárbara Vicente dos Santos | Faculty of Pharmacy University of Coimbra, Portugal |
2021/09 - 2021/09 | BSc monograph, Integrated Master in Pharmaceutical Sciences - Title: Organoides Cerebrais na Modelação de Doenças Degenerativas e Infeciosas; Student: Maria Gabriela Meneses Costa | Faculty of Pharmacy University of Coimbra, Portugal |
2019/07 - 2019/07 | BSc monograph, Integrated Master in Pharmaceutical Sciences - Title: Processos Biotecnológicos aplicados ao Transplante de Órgãos; Student: Sara Henrique Silvestre Neves Jacinto | Faculty of Pharmacy University of Coimbra, Portugal |
Distinctions
Award
2022 | Best Oral Presentation - Co-authorship of the work "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair." |
2022 | Best Poster - ATXN3 alternative splicing in spinocerebellar ataxia type 3/Machado-Joseph disease: diversity and abundance
of transcripts in the cerebellum and blood
Sociedade Portuguesa de Genética Humana, Portugal
|
2019 | NAF Young Investigador SCA 2019
National Ataxia Foundation, United States
|
2017 | Basic Science Award - co-authorship of the work "Silencing Spinocerebellar Ataxia Type 3 through the systemic route."
Sociedade Portuguesa das Doenças do Movimento, Portugal
|
2016 | Best Poster - First author of the work "Preclinical studies with Trehalose for MJD: in vitro and in vivo models."
Institute of Medical Genetics and Applied Genomics, Germany
|
2016 | NAF Post-doc Fellowship Award 2016 |
2016 | Clinical Investigation Award - co-authorship of the work "Non-invasive and viral-mediated silencing of mutant ataxin-3 alleviates
motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease"
Sociedade Portuguesa de Genética Humana, Portugal
|
2014 | Pergunta-me Ciência
Ciência Viva, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2013 | Poster award - co-authorship of the work "NPY cleaved by dipeptidyl-peptidase IV (DPPIV) induces preadipocytes differentiation." |
2010 | 2nd prize - Research potential in the field of obesity with project untitled : The Neuropeptide Y as a promising target on the adipose tissue regulation¿ (member of the researcher team) |
2010 | 3% best students of Pharmaceutical Sciences of the University of Coimbra - Academic year 2007/2008
Universidade de Coimbra, Portugal
|
2008 | 3% best students of Pharmaceutical Sciences of the University of Coimbra - Academic year 2006/2007
Universidade de Coimbra, Portugal
|
2007 | 3% best students of Pharmaceutical Sciences of the University of Coimbra - Academic year 2005/2006
Universidade de Coimbra, Portugal
|
Other distinction
2008 | PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
|