
Curriculum Vitae
Magda Matos Santana
Magda M Santana (PharmD, PhD) is a junior researcher interested in translational research in Neurosciences field. As undergraduate
student, MMS was in the ranking of the 3% Best Students of Pharmaceutical Sciences. MMS finished her Integrated Master in
Pharmaceutical Sciences (final classification 17/20), in 2008, and got her Doctoral degree in Pharmacy (Pharmacology and Pharmacotherapy)
at University of Coimbra, Portugal, in 2013. In 2014, Magda was invited by Prof. Luis Pereira de Almeida to join the Vectors,
Gene and Cell Therapy | Molecular Therapy of Brain disorders group and since then she has been focused her research in the
development of biomarkers, pre-clinical models (iPSCs and rodents) and drug/gene therapies for MJD, in straight collaboration
with other team members, international partners and pharmaceutical companies. In total, Magda has been part of the research
team of about 25 projects (including two international consortia: JPNDcoFund ESMI and ModelPolyQ). MS was awarded twice by
the National Ataxia Foundation, the most prominent foundation supporting research in the US within ataxias field, with a post-doctoral
grant (2016, $35 000) and with the SCA Young Investigator Award (2019), with a $50 000 budget attributed for developing a
systems biology approach for biomarker discovery. Magda got international scientific experience as undergraduate student
(Erasmus Program, London¿s University, UK), as PhD student (Dresden University, Germany) and as post-doctoral researcher (training
programs/courses in Luxembourg and Germany) and has actively participated in both national and international scientific meetings,
being first or co-author of over 80 oral/poster communications. Magda is author/co-author of 24 papers/3 book chapters in
peer-reviewed international journals, 18 conference abstracts and was/is supervisor/co-supervisor of 3 PhD Student, 6 MSc
students and several graduate/undergraduate students. Magda has been invited to give practical classes and lectures in graduate
courses and programmes, is responsible for support to the coordination of the Master in Pharmaceutical Biotechnology (Faculty
of Pharmacy, University of Coimbra) and has participating in academic examining committees of MSc/PhD Thesis. Magda was also
invited by NAF for grant evaluation. Magda engaged several scientific communication and knowledge transference public activities,
such European Researcher s night, Ciência Viva, Brain Awareness Week and Rare Disease Day and is an active member of the SCA
Global and SCA Global Young Investigator Initiative.
Identification
Personal identification
- Full name
- Magda Matos Santana
Citation names
- Santana, Magda M
- Santana MM
- Santana M
- Magda M Santana
Author identifiers
- Ciência ID
- 3E17-9ED3-1C8D
- ORCID iD
- 0000-0003-4076-7516
Email addresses
- mmsantana@uc.pt (Professional)
- magda.santana@cnc.uc.pt (Professional)
Websites
- https://cibb.uc.pt/research/innovative-therapies/vectors-gene-cell-therapy/ (Professional)
- https://cnc.uc.pt/en/research-group/gene-and-stem-cell-therapies-for-the-brain (Professional)
Knowledge fields
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
- Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
French | Beginner (A1) | Intermediate (B1) | Beginner (A1) | Beginner (A1) | |
Spanish; Castilian | Beginner (A1) | Intermediate (B1) | Beginner (A1) | ||
English | Intermediate (B1) | Intermediate (B1) | Intermediate (B1) | Intermediate (B1) |
Education
Degree | Classification | |
---|---|---|
2023/04
Concluded
|
COURSE: Summer School in Personalized Medicine - Multimodel Biomarkers and Diagnostics (Outros)
European Infrastructure for Translational Medicine, Netherlands
|
|
2013 - 2018
Concluded
|
Post-doctoral Fellow (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2016/07
Concluded
|
COURSE: From Next Generation Sequencing to Translational Medicine in Neurological Disease Research (Outros)
Universitatsklinikum Tübingen Institut für Medizinische Genetik und angewandte Genomik, Germany
|
|
2016/06/10
Concluded
|
TRAINING: iPSC derivation and differentiation techniques (Outros)
Université du Luxembourg Luxembourg Centre for Systems Biomedicine, Luxembourg
|
|
2016
Concluded
|
COURSE: Statistics applied to laboratories (Outros)
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
|
|
2013/12
Concluded
|
CERTIFICATION: Investigator-Coordinator for animal experimentation (Outros)
Direção-Geral de Alimentação e Veterinária, Portugal
|
|
2013/10/04
Concluded
|
COURSE: Laboratory Animal Science - FELASA C (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2008/10/01 - 2013/07/26
Concluded
|
Pharmacy (Pharmacology and Pharmacotherapy) (Doutoramento)
Major in Farmacologia e Farmacoterapia
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
Louvor e distinção |
2010/12/09
Concluded
|
COURSE: Advanced course "The complex world of RNA" (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2010/05/21
Concluded
|
COURSE: Advanced Course in Real-time PCR (Outros)
TATAA Biocenter, Sweden
|
|
2009/10/02
Concluded
|
COURSE: Advanced course "Biostatistics" - PDBEB Programme (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2009
Concluded
|
PhD Student - Internship - Neuroendocrinology (Outros)
Technische Universität Dresden, Germany
Universitätsklinikum Carl Gustav Carus, Germany |
|
2002/10 - 2008/07
Concluded
|
Pharmaceutical Sciences (Mestrado integrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
17/20 |
2007
Concluded
|
ERASMUS Program: Undergraduate training in Pharmaceutical Sciences (Outros)
University College London Department of Pharmaceutical and Biological Chemistry, United Kingdom
|
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2019/01/15 - Current | Contracted Researcher (Research) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Positions / Appointments
Category Host institution |
Employer | |
---|---|---|
2017 - Current | Coordinator of human ESMI biobank | European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative, Germany |
2018/08/01 - 2022/07/31 | Coordination support to Master in Pharmaceutical Tecnology | Universidade de Coimbra Faculdade de Farmácia, Portugal |
Universidade de Coimbra Faculdade de Farmácia, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2025 - Current | GENEH: EXCELLENCE HUB FOR ADVANCING INNOVATION IN GENE THERAPY
n/a
Researcher
|
|
2024 - Current | GeneT - The Gene Therapy CoE at the Center of Portugal
101059981
Researcher
|
|
2024 - Current | ERDERA - European Rare Diseases Research Alliance
n/a
Researcher
|
|
2023/09/01 - Current | NEURODIET - Molecular Mechanisms of Dietary Intervention on Neurodegeneration (PT001)
JPND/0001/2022
Universidade de Coimbra, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023/01/01 - Current | CInTech: Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
C644865576-00000005
Researcher
|
|
2022 - Current | (Less)PlasticBrain – Bio Replacing Plasticizers – Impact in the Human Brain Development.
n/a
Researcher
|
Concluded
|
2016/05 - 2020/03 | Iniciativa Europeia para a doença de Machado-Joseph / Ataxia Espinocerebelosa do tipo 3
Provided by PTCRIS: JPCOFUND/0001/2015
|
Fundação para a Ciência e a Tecnologia |
2016/04 - 2020/03 | Modelos avançados de doenças de poliglutaminas
Provided by PTCRIS: JPCOFUND/0005/2015
|
Fundação para a Ciência e a Tecnologia |
2008/10 - 2012/09 | CROSSTALK BETWEEN ADIPOCYTES AND ADRENAL GLAND CELLS: INFLUENCE OF OBESITY ON ADRENAL CELL DIFFERENTIATION AND FUNCTION
Provided by PTCRIS: SFRH/BD/44664/2008
|
Fundação para a Ciência e a Tecnologia |
Contract
Designation | Funders | |
---|---|---|
2019/01/01 - 2019/12/31 | CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
2011/03/01 - 2014/08/31 | iCALP - Identificação das funções fisiológicas das calpaínas no controlo da proliferação e migração celulares no sistema nervoso
central
PTDC/SAU-NMC/112183/2009
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2011/01/01 - 2012/12/31 | Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Other
Designation | Funders | |
---|---|---|
2023/03/01 - Current | From bedside-to-bench” biomarker discovery: on the road to a clinical trial for Machado-Joseph Disease
2022.06118.PTDC
Principal investigator
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023/03/01 - Current | AstroIN2Neurons – Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia
Type-3
2022.06127.PTDC
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2022/08/01 - Current | Machado-Joseph Disease iPSC Cell Models for Medium Throughput Drug Screening
--
Researcher
|
Les Laboratoires Servier SAS
Ongoing
|
2022/07/01 - Current | BDforMJD - Biomarker development for Machado-Joseph Disease
CENTRO-01-0145-FEDER-181240
Principal investigator
|
European Regional Development Fund
Ongoing
|
2022/07/01 - Current | ModelPolyQ 2.0 - Advanced Animal Models for Polyglutamine Diseases 2.0
CENTRO-01-0145-FEDER-181258
Researcher
|
European Regional Development Fund
Ongoing
|
2022/07/01 - Current | Gene editing systems for the ATXN3 gene: a therapy for Machado-Joseph disease
CENTRO-01-0145-FEDER-181266
Researcher
|
European Regional Development Fund
Ongoing
|
2022/01/01 - Current | Genome editing to rescue Machado-Joseph disease by alternative splicing
EXPL/MED-NEU/0936/2021
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2020/01/01 - Current | Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Researcher
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2020/01 - 2022/12 | Characterization of iPSCs and YAC mouse model of Machado-Joseph Disease
-
Researcher
|
F Hoffmann-La Roche AG
Concluded
|
2017/02/01 - 2022/03/31 | Viravector - Infrastructure of the national roadmap for production and research with viral vectors
CENTRO-01-0145-FEDER-022095
Researcher
|
European Regional Development Fund
Concluded
|
2019 - 2021 | A systems approach to find a blood-based biomarker for Machado-Joseph Disease
SCA Young Investigator Award
Principal investigator
|
National Ataxia Foundation
Concluded
|
2017/01/01 - 2020/12/31 | BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Post-doc Fellow
|
European Regional Development Fund
Concluded
|
2016/04/01 - 2020/05/31 | ModelPolyQ - Advanced models of polyglutamine disorders (Huntington's disease, SCA3 and SCA7)
Researcher
|
EU Joint Programme Neurodegenerative Disease Research
Concluded
|
2016/01/01 - 2020/05/29 | ESMI - European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
Researcher
|
EU Joint Programme Neurodegenerative Disease Research
Concluded
|
2019 - 2020 | JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
JPCOFUND/0001/2015-ESMI
|
|
2013/04 - 2015/09 | Aging, Stress And Chronic Diseases: From Mechanisms to Therapeutics
CENTRO-07-ST24-FEDER-002006
Post-doc Fellow
|
FEDER (QREN), through Programa Mais Centro
Concluded
|
2015 - 2015 | Caballeta@CNC-Study 3
---
Post-doc Fellow
|
BioBlast Pharma
Concluded
|
2011/03 - 2014/08 | iCALP - Identification of the physiological roles of calpains in the control of cell proliferation and migration in the central
nervous system
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2014 - 2014 | Caballeta@CNC-Study 2
----
Other
|
BioBlast Pharma
Concluded
|
2014 - 2014 | Caballeta@CNC-Study 1
-------
Post-doc Fellow
|
BioBlast Pharma
Concluded
|
2013/08 - 2013/12 | Preclinical study in an animal model of depression
------
Post-doc Fellow
|
Grupo Tecnimede
Concluded
|
2010/04 - 2013/07 | Effect of caffeine and adenosine A2A receptors on stress response: role of adrenal gland modulation
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2010 - 2013 | Caloric restriction increases lifespan: role of NPY on autophagy
PTDC/SAU-FCF/099082/2008
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2010/02 - 2012/09 | The Neuropeptide Y (NPY) and Dipeptidyl-peptidase IV (DPPIV) as new promising targets on the adipose tissue regulation in
obesity
Research Fellow
|
Fundação para a Ciência e a Tecnologia, I.P. |
2007/05 - 2010/11 | Neuropeptide Y in the retina: Why? What for?
Research Fellow
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2009 - 2009 | The Neuropeptide Y as a promising target on the adipose tissue regulation
n/a
Research Fellow
|
Portuguese Society of Endocrinology, Diabetes and Metabolism (SPEDM) Abbott Laboratórios Lda Concluded
|
Outputs
Publications
Book chapter |
|
Conference abstract |
|
Conference paper |
|
Conference poster |
|
Journal article |
|
Manual |
|
Newspaper article |
|
Preprint |
|
Thesis / Dissertation |
|
Other
Other output |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2024/11/14 | Cognitive impairment in SCA3: a multi-center cohort study with demographic and biomarker correlates | International Congress for Ataxia Research
(London, United Kingdom)
|
2024/11/14 | CRISPR-Cas9-mediated ATXN3 gene inactivation as a potential therapeutic approach for Machado-Joseph disease | International Congress for Ataxia Research
(London, United Kingdom)
|
2024/11/14 | Allele-specific silencing of mutant ataxin-3 via single administration of AAV9 vectors mitigates neuropathology and motor deficits in Spinocerebellar Ataxia Type 3 | International Congress for Ataxia Research
(London, United Kingdom)
|
2024/11/13 | Longitudinal analysis of clinical outcomes and plasma NfL, total tau, GFAP and UCHL1 in spinocerebellar ataxia type 3/Machado-Joseph disease. | International Congress for Ataxia Research
(London, United Kingdom)
|
2022/11/17 | Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair. | 26th Annual Portuguese Society of Human Genetics Meeting
Portuguese Society of Human Genetics (Coimbra, Portugal)
|
2022/11 | ATXN3 alternative splicing in spinocerebellar ataxia type 3/Machado-Joseph disease: diversity and abundance of transcripts in the cerebellum and blood | 26th Annual Meeting of the Portuguese Society of Human Genetics
Portuguese Society of Human Genetics
|
2022/02/10 | Medication patterns of Machado-Joseph disease patients enrolled in the ESMI cohort: a retrospective study | LII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
|
2022/02 | Correction of ATXN3-CAG expansion in MJD patient-derived iPSC by CRISPR/Cas9 homology-directed repair. | LII Portuguese Society of Pharmacology Meeting
Portuguese Society of Pharmacology (Porto, Portugal)
|
2021/02/19 | Phenotypic characterization of neuronal cultures derived from Machado Joseph-Disease induced pluripotent stem cells. | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/19 | Phenotypic characterization of a relevant model of Machado-Joseph disease: the YAC-MJD mouse model | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/19 | European Spinocerebellar Ataxia type 3/ Machado-Joseph Disease initiative: clinical overview of the Coimbra's cohort | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/18 | Brain micrornas in plasma-derived extracellular vesicles as potential biomarkers for Machado-Joseph Disease. | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2021/02/18 | Identification of dysregulated mirnas in human induced pluripotent stem cell-based models of Machado-Joseph Disease: one step closer to a therapeutic approach? | LI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
2019/12 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain disorders | 1st Annual Meeting in Pharmaceutical Sciences
(Coimbra, Portugal)
|
2019/11 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases | 5th GEIVEX Symposium
(Granada, Spain)
|
2019/11 | miRNA expression profile of plasma-derived extracellular vesicles distinguishes Machado-Joseph Disease patients from controls | 23rd Annual Meeting, Portuguese Society of Human Genetics
(Coimbra, Portugal)
|
2019/05 | Characterization and follow-up of the Coimbra cohort of Machado-Joseph Disease Patients | 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
(Coimbra, Portugal)
|
2019/05 | A miRNA-based gene therapy approach to knock-down mutant ATXN3: alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration | 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
(Coimbra, Portugal)
|
2019/03 | Serum neurofilaments in SCA3. 1st SCA Global Conference, Wilke C et al. "on behalf of ESMI Consortium" | 1st SCA Global Conference,
(las vegas, United States)
|
2019/02 | Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases | XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
(Porto, Portugal)
|
2019/02 | Characterization of a trial-ready cohort of Machado-Joseph disease patients: status update | XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
(Porto, Portugal)
|
2019 | Blood biomarker quantification in SCA3 samples. 1st SCA Global Conference, Garcia-Moreno H et al. "on behalf of ESMI consortium" | 1st SCA Global Conference,
(las vegas, United States)
|
2019 | Blood biomarker quantification in SCA3 samples using the Neurology 4-PLEX A kit and the Simoa technology. International Ataxia Research Conference (IARC), Garcia-Moreno H et al. "on behalf of ESMI Consortium" | International Ataxia Research Conference (IARC) |
2019 | European Spinocerebellar Ataxia Type 3/Machado- Joseph Disease Initiative (ESMI). JPco-fuND symposium, Klockgether T. "on behalf of ESMI Consortium" | |
2018/05 | ESMI Biomarkers studies: status and research plan | 3rd JPND-ESMI meeting
ESMI consortium (Ponta Delgada, Azores, Portugal)
|
2018/05 | Non-invasive brain delivery with hybrid extracellular vesicles (EVs) for therapy of Machado-Joseph disease (MJD) | International Society for Extracellular Vesicles Annual Meeting
(Barcelona, Spain)
|
2018/02 | Hybrid vesicles: a promising therapeutic approach for Machado-Joseph disease. | 1st Meeting on Vesicle Biology
(Coimbra, Portugal)
|
2018/02 | Generation of a Machado-Joseph disease isogenic control induced pluripotent stem cell line | XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia clínica, XVII Reunião de toxicologia
(Lisboa, Portugal)
|
2018/02 | Characterization of a trial-ready cohort of Machado-Joseph disease patients | XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia clínica, XVII Reunião de toxicologia
(Lisboa, Portugal)
|
2018/02 | Non-invasive and allele specific gene silencing therapy for Machado Joseph disease and a biomaker to monitor the therapeutic response | XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia clínica, XVII Reunião de toxicologia
(Lisboa, Portugal)
|
2018/01 | Exosomes: tiny vesicles with great potential for MJD treatment | XII Spanish-Portuguese Conference on Controlled Drug Delivery.
(Coimbra, Portugal)
|
2017/07 | Generation of iPSCs for Machado Joseph Disease/Spinocerebellar ataxia type 3 | 2nd JPND-ModelPolyQ meeting
(Strasbourg, France)
|
2017/05 | Workpackge 4 – Biomarkers for Machado Joseph-disease | 2nd JPND-ESMI meeting
(Coimbra, Portugal)
|
2017/05 | Non-invasive silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease | Congresso Nacional da Sociedade Portuguesa de Neurociências (SPN)
(Braga, Portugal)
|
2017/04 | Silencing Spinocerebellar Ataxia Type 3 trough the systemic route | Congresso Nacional da Sociedade Portuguesa das Doenças do Movimento (SPDMov)
(Ofir, Portugal)
|
2017/02 | Silencing MJD trough the systemic route | XLVII Reunião da Sociedade Portuguesa de Farmacologia, XXXV Reunião de Farmacologia clínica, XVI Reunião de toxicologia
(Coimbra, Portugal)
|
2016/11 | Non-invasive and viral-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease | 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana (SPGH)
(Coimbra, Portugal)
|
2016/03 | Trehalose reverses the phenotype of Machado-Joseph disease models | 10th World Congress on Controversies in Neurology (CONy)
(Lisboa, Portugal)
|
2016/02 | Trehalose reverses disease phenotype in both in vitro and in vivo models of Machado-Joseph disease transgenic mice | XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
(Porto, Portugal)
|
2016/02 | Silencing Machado-Joseph disease/Spinocerebellar ataxia type 3 through the systemic route | XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
(Porto, Portugal)
|
2016/02 | The role of NPY on the hypothalamic circadian clock genes | XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
(Porto, Portugal)
|
2014/02 | Role of chromaffin progenitor cells on adrenal medulla response to stress | XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXII Reunião anual de Farmacologia Clínica e XIII Reunião de
Toxicologia
(Coimbra, Portugal)
|
2013/02 | Chronic unpredictable stress, as a model of depression, induces changes in mouse adrenal gland | XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião anual de Farmacologia Clínica e XII Reunião de Toxicologia
(Porto, Portugal)
|
2012/12 | Chromaffin progenitor cells: Isolation, characterization, differentiation and putative role on adrenal medulla adaptation to stress | X CNC meeting
(Coimbra, Portugal)
|
2012/09 | Chronic unpredictable stress induces catecholaminergic system changes in mouse adrenal gland | X International Catecholamine Symposium
(Pacific Grove, CA, United States)
|
2012/02 | Characterization and differentiation of progenitor cells from normal adult human adrenal medulla | XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXX Reunião anual de Farmacologia Clínica e XI Reunião de Toxicologia
(Lisboa, Portugal)
|
2011/02 | Adenosine A1 and A2A receptors in mouse adrenal gland: localization and catecholamine release modulation | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | Hypoxia has dual effects on adipocyte differentiation: relevance on obesity | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | Gliptins inhibit lipid accumulation in a murine pre-adipocyte cell line | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | Hypothalamic progenitor cells differentiate into functional neurons | ) XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2011/02 | ß-adrenergic receptors activation in human adrenal chromaffin cells: role on catecholamines release | XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião anual de Farmacologia Clínica e X Reunião de Toxicologia
(Coimbra, Portugal)
|
2010/12 | Modulation of Neuropeptide Y in the adult hypothalamus and hypothalamic neurospheres – role on feeding behavior | VIII CNC Meeting
(Coimbra, Portugal)
|
2010/11 | Does the hypoxia-mimetic agent, CoCl2, have a dual effect on adipogenesis | 1 st International Diabetes and Obesity Forum
(Atenas, Greece)
|
2010/11 | The role of selective inhibitor dipeptidyl-peptidase IV (DPPIV) on the adipogenesis of 3T3-L1 pre-adipocyte murine cell line | 14º Congresso Português de Obesidade
(Coimbra, Portugal)
|
2010/05 | The role of hypoxia on pre-adipocyte proliferation and adipocyte differentiation | Survival or Death as a Matter of Fat
(Coimbra, Portugal)
|
2010/01 | NPY plays na important role in adipose tissue formation regulating adipocytes proliferation and differentiation through different mechanisms | Neuronal Control of Appetite, Metabolism and Weight
(Keystone, Colorado, United States)
|
2009/12 | Isolation and characterization of progenitor cells from normal adult human adrenal medulla | ) XL Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVIII Reunião anual de Farmacologia Clínica e IX Reunião de Toxicologia
(Porto, Portugal)
|
2009/10 | Dipeptidylpeptidase IV (DPPIV) stimulates the proliferation and differentiation of 3T3L1 preadipocyte murine cell line | Obesity 2009 - 27th Annual Scientific Meeting of the Obesity Society
(Washington DC, United States)
|
2009/01 | The increase of pre-adipocyte proliferation induced by dipeptidyl-peptidase IV (DPPIV) is inhibited by vildagliptine | Encontro Nacional da Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolism
(Vilamoura, Portugal)
|
2009 | The neuropeptide Y cleaved by dipeptidylpeptidase IV (DPPIV) producing endogenous NPY Y2 agonist, induces preadipocytes proliferation and differentiation | XL Reunião da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2020/10/18 - 2021/08/01 | Tackling CANcer STEM CELLs: a challenge and an opportunity to advance in anti-cancer therapy
Co-supervisor of Diana Cristina Antunes Candeias Adão
|
|
2018/06/01 - 2021/03/01 | BrainHealth 2020 : Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
Supervisor of Patricia Alexandra Rosado Albuquerque
|
|
2020 - 2021 | The Role of The Immune System in Polyglutamine Diseases
Supervisor of Isa Morais Penas
|
Master in Pharmaceutical Biotechnology
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2020 - 2021 | Machado-Joseph Disease Comorbidities and Symptomatic Treatments: a large cohort analysis
Supervisor
|
Master in Pharmaceutical Biotechnology
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019 - 2020/12 | Brain-enriched plasma-derived extracellular vesicles as biomarkers for Machado-Joseph disease
Supervisor of Maria Manuel Martins Pinto
|
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019/11/19 - 2020/09/30 | BrainHealth 2020 : Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
Co-supervisor of Kevin Costa Leandro
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
2019 - 2020 | Phenotypic characterization of cellular and animal models of Machado-Joseph disease
Supervisor
|
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2017/03 - 2017/07 | Characterization of healthy controls and MJD patient's derived induced pluripotent stem cells (iPSc)
Co-supervisor of Rachele di Donato
|
Medical, Veterinary and Pharmaceutical Biotechnology (Master)
Università degli Studi del Sannio, Italy
Università degli Studi di Foggia, Italy |
2016/01 - 2016/07 | Clarifying the Mechanism of Action of Trehalose on Alleviating Machado-Joseph Disease
Co-supervisor of Allyson Trèvino
|
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
|
2015/05 - 2015/07 | Estudos pré-clínicos em modelos animais com a doença de Machado-Joseph
Supervisor of Patrícia Ines Pires dos Santos
|
Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2018 - Current | Rare diseases day@CNC (2018/02/28) | |
2025/02/25 - 2025/02/25 | Iniciativas para a Doença de Machado Joseph e outras ataxias: de olhos no futuro" (2025/02/25)
Meeting
|
|
2024/11/12 - 2024/11/15 | International Ataxia Conference 2024 (2024/11/11) | |
2020 - 2020 | Machado-Joseph Disease: From Laboratory to Society - Rare Disease Day 2020, Centre for Neuroscience and Cell Biology. Coimbra,
Portugal. February 2020. (2020/02/28)
Meeting (Co-organisor)
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2017/05/22 - 2017/05/23 | 2nd JPND ESMI meeting. CNC, May 22-23, Coimbra, Portugal. 2017 (2017 - 2017)
Meeting (Co-organisor)
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2016 - 2016 | 1st Symposium on aging research. CNC. Sep 30, Coimbra, Portugal. 2016 (2016 - 2016) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2016 - 2016 | 1st JPND ModelPolyQ meeting. CNC, Jul 4-5, Coimbra, Portugal. 2016 (2016 - 2016)
Meeting
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2016 - 2016 | 1st International Symposium Brain Without Borders. November 18-19, Coimbra, Portugal. 2016 (2016 - 2016)
Symposium (Member of the Organising Committee)
|
Event participation
Activity description Type of event |
Event name Institution / Organization |
|
---|---|---|
2018 - Current | European Researchers' Night 2018 | European Researchers' Night 2018 |
2018 - Current | Brain Awareness Week |
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2022/09/01 | CHARACTERIZATION OF THE GENETIC PROFILE OF PATIENTS WITH FRONTOTEMPORAL LOBAR DEGENERATION AND ESTABLISHMENT OF THEIR FIBROBLAST
CELL LINES
(Thesis) Main arguer
|
António Miguel Mira Nunes (Master) |
2022/09 | EXTRACELLULAR VESICLES: FROM BRAIN COMMUNICATION TO THERAPEUTIC DELIVERY
(Thesis) Arguer
|
António David Rufino Ramos (PhD) |
2019/09 | A DIFFERENT PERSPECTIVE OF CIRCULATORY BIOMARKERS IN NEURODEGENERATIVE DISEASES: FOCUS ON SERUM HIGH MOLECULAR WEIGHT FRACTION
(Thesis) Main arguer
|
Miguel Maria Varandas Anão Rosado (Master) |
2019/09 | CERVICAL CANCER SCREENING: SELFSAMPLING AS A COMPLEMENT TO THE CONVENTIONAL METHOD
(Thesis) Main arguer
|
Sara da Graça Marques Pereira (Master) |
2019/08 | THE ROLE OF AGEING IN POLYGLUTAMINE INDUCED NEURODEGENERATION. A STUDY IN MACHADO-JOSEPH DISEASE MODELS
(Thesis) Arguer
|
Dina Maria da Silva Rodrigues Pereira (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
|
2019 | CERVICAL CANCER SCREENING: SELF-SAMPLING AS A COMPLEMENT TO THE CONVENTIONAL METHOD | Sara da Graça Marques Pereira (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019 | A DIFFERENT PERSPECTIVE OF CIRCULATORY BIOMARKERS IN NEURODEGENERATIVE DISEASES: FOCUS ON SERUM HIGH MOLECULAR WEIGHT FRACTION | Miguel Maria Varandas Anão Rosado (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
2019 | HISTOLOGICAL AND MORPHOLOGICAL ANALYSIS OF DEVELOPING NEURONAL PRECURSORS DERIVED FROM HUMAN IPS CELLS
(Thesis) Main arguer
|
Daniela Catarina Gaspar Santos (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
|
2015/09/29 | NOVOS SISTEMAS PARA PENETRAÇÃO DA BARREIRA HEMATOENCEFÁLICA: DAS MICROBOLHAS À FOCAGEM DE ULTRASSONS
(Thesis) Main arguer
|
Luís Miguel Lopes Martinho (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
|
Ad Hoc journal article review
Journal title (ISSN) | Publisher | |
---|---|---|
2023 - 2023 | Human Molecular Genetics | |
2022 - 2022 | Frontiers in Neuroscience | |
2022 - 2022 | Biomedicines |
Association member
Society Organization name | Role | |
---|---|---|
2020/10/19 - Current | SCA Global Young Investigator Initiative - http://ataxia-global-initiative.net/young-investigator-initiative-yii/yii/ | Founder member - in collaboration with Jennifer Faber and Heike Jacobi |
2018/04/02 - Current | SCA Global Initiative - http://ataxia-global-initiative.net/sca-global/ | Member |
2018/01/01 - Current | Neurosciences Portuguese Society |
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2024 - Current | Lecture: Gene Therapy for Brain Disorders | Master in Biomedical Sciences | Universidade dos Açores, Portugal |
2024 - Current | Human molecular genetics | Master | Faculty of Pharmacy University of Coimbra, Portugal |
2024 - Current | Molecular an Cellular Biology | Faculty of Pharmacy University of Coimbra, Portugal | |
2019/04/22 - Current | Biomarkers in drug development | Drug development Course - PhD Programme in Experimental Biology and Biomedicine | |
2022/11/02 - 2022/11/02 | "Induced pluripotent stem cells for brain disease modelling." invited lecture in Workshop in Viral Vectors and induced pluripotent stem cells for the central nervous system. | Portuguese Glial Network, Portugal | |
2019 - 2020 | Pharmacological screening | Farmácia Biomédica (Licenciatura) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2019 - 2020 | Pre-clinical drug development | Farmácia Biomédica (Licenciatura) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2019/11/13 - 2019/11/13 | Curso Ataxias hereditárias e paraparésias espásticas: da biologia molecular ao tratamento | (Outros) | |
2018/05/08 - 2018/05/08 | Biomarkers | PhD Programme in Experimental Biology and Biomedicine - CNC (Doutoramento) | Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal |
2018/04/28 - 2018/04/28 | Induced Pluripotent Stem Cells: biobank and disease modelling | Biotecnologia Farmacêutica (Mestrado integrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2017/06/09 - 2017/06/09 | Biomarcadores em doença neurodegenerativa: oportunidades e dificuldades | Farmacologia Aplicada (Mestrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2017/04/08 - 2017/04/08 | Induced Pluripotent Stem Cells: biobank and disease modelling | Biotecnologia Farmacêutica (Mestrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2016/12/06 - 2016/12/06 | Genetic aproaches to fight neurodegenerative diseases | Neurociências | Instituto de Medicina Molecular João Lobo Antunes, Portugal |
2016/06/25 - 2016/06/25 | Elaboração de um plano de estudo em ensaios pré-clínicos | Farmacologia Aplicada (Mestrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2013 - 2014 | Human anatomy and physiology | Ciências Farmacêuticas (Mestrado integrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2010 - 2013 | Histologia e Embriologia Humana | Ciências Farmacêuticas (Mestrado integrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2011 - 2011/01/31 | Stem cells in adult adrenal medulla…or not? | PhD Programme in Experimental Biology and Biomedicine - CNC, Coimbra | Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal |
2009 - 2010 | Screening Farmacológico | Farmácia Biomédica (Licenciatura) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
Evaluation committee
Activity description Role |
Institution / Organization | Funding entity | |
---|---|---|---|
2019 - Current | National Ataxia Foundation - Evaluation panel of Scientific calls |
Interview (newspaper / magazine)
Activity description | Newspaper / Forum | |
---|---|---|
2019/11/14 | Entrevista no âmbito do curso "Ataxias hereditárias e paraparésias espásticas: da biologia molecular ao tratamento", no Congresso de Neurologia 2019. | Correio SPN |
Other jury / evaluation
Activity description | Institution / Organization | |
---|---|---|
2022/09/23 - 2022/09/23 | PhD project defense - PhD program in Pharmaceutical Sciences Faculty of Pharmacy of the University of Coimbra; PhD Student: Bárbara Vicente dos Santos | Faculty of Pharmacy University of Coimbra, Portugal |
2021/09 - 2021/09 | BSc monograph, Integrated Master in Pharmaceutical Sciences - Title: Organoides Cerebrais na Modelação de Doenças Degenerativas e Infeciosas; Student: Maria Gabriela Meneses Costa | Faculty of Pharmacy University of Coimbra, Portugal |
2019/07 - 2019/07 | BSc monograph, Integrated Master in Pharmaceutical Sciences - Title: Processos Biotecnológicos aplicados ao Transplante de Órgãos; Student: Sara Henrique Silvestre Neves Jacinto | Faculty of Pharmacy University of Coimbra, Portugal |
Distinctions
Award
2022 | Best Oral Presentation - Co-authorship of the work "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair." |
2022 | Best Poster - ATXN3 alternative splicing in spinocerebellar ataxia type 3/Machado-Joseph disease: diversity and abundance
of transcripts in the cerebellum and blood
Sociedade Portuguesa de Genética Humana, Portugal
|
2019 | NAF Young Investigador SCA 2019
National Ataxia Foundation, United States
|
2017 | Basic Science Award - co-authorship of the work "Silencing Spinocerebellar Ataxia Type 3 through the systemic route."
Sociedade Portuguesa das Doenças do Movimento, Portugal
|
2016 | Best Poster - First author of the work "Preclinical studies with Trehalose for MJD: in vitro and in vivo models."
Institute of Medical Genetics and Applied Genomics, Germany
|
2016 | NAF Post-doc Fellowship Award 2016 |
2016 | Clinical Investigation Award - co-authorship of the work "Non-invasive and viral-mediated silencing of mutant ataxin-3 alleviates
motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease"
Sociedade Portuguesa de Genética Humana, Portugal
|
2014 | Pergunta-me Ciência
Ciência Viva, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2013 | Poster award - co-authorship of the work "NPY cleaved by dipeptidyl-peptidase IV (DPPIV) induces preadipocytes differentiation." |
2010 | 2nd prize - Research potential in the field of obesity with project untitled : The Neuropeptide Y as a promising target on the adipose tissue regulation¿ (member of the researcher team) |
2010 | 3% best students of Pharmaceutical Sciences of the University of Coimbra - Academic year 2007/2008
Universidade de Coimbra, Portugal
|
2008 | 3% best students of Pharmaceutical Sciences of the University of Coimbra - Academic year 2006/2007
Universidade de Coimbra, Portugal
|
2007 | 3% best students of Pharmaceutical Sciences of the University of Coimbra - Academic year 2005/2006
Universidade de Coimbra, Portugal
|
Other distinction
2008 | PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
|