Mónica Santos (4012-F7AE-EC08)

Curriculum Vitae

Mónica Santos

Mónica Santos. Completed her PhD in Biomedical Sciences (2007) by the University of Porto, Institute of Biomedical Sciences Abel Salazar and her B.Sc. in Biology (2000) by the University of Porto, Faculty of Sciences. She is a Researcher in the University of Coimbra, Center for Neurosciences and Cell Biology. She published 25 articles in peer-reviewed journals. Organized scientific and public outreach events and kept a continuous scientific formation by attending top scientific meetings, participating in workshops and conferences and got training in soft skills. She co-supervised 2 PhD theses and 4 MSc theses and supervised several postgraduate students. She has received 8 awards and/or honors. Participates and/or participated as Principal Investigator in 4 projects and as Team member in 12 other projects. She earned 3 highly competitive fellowships, 1 PhD and 2 Pos-doctoral fellowships. Works in the area of Medical and Health Sciences with emphasis on Basic Medicine and Neurosciences. In her professional activities interacted with 309 collaborators, including collaborations from the non-academic sector (notably hospitals) and overseas (USA) with co-authorship of scientific papers. In her curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: NT3-TrkC; FMR1; MECP2; Anxiety; Fear; Learning and Memory; Neurotrophins; Animal models; Neurodegeneration; Rett syndrome; Down syndrome; FXTAS; Rodent behavior; Endocannabinoids; Mecp2-mutants; Fear conditioning; Fear extinction; FMR1 premutation; Gene therapy; Ts65Dn mouse model; Intellectual disability; TrkC; Neurotrophin 3; Neurodevelopment; Autism; MECP2 mutations; Multiple Sclerosis; Genetic markers; Social behaviour; Olfactory system; Mouse model; Noonan syndrome; Rasopathies; microRNA; Panic disorder; Public Outreach .

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Identification

Personal identification

Full name: Mónica Santos

Citation names

Santos, Mónica
Santos, M
Santos, Monica

Author identifiers

Ciência ID: 4012-F7AE-EC08
ORCID iD: 0000-0003-3229-8270

Websites

http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1110 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Catalan	Elementary (A2)	Upper intermediate (B2)	Elementary (A2)	Upper intermediate (B2)	Elementary (A2)
French	Elementary (A2)	Upper intermediate (B2)	Elementary (A2)	Elementary (A2)	Elementary (A2)
German	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Beginner (A1)

Education

	Degree	Classification
2002/02/20 - 2007/12/20 Concluded	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Pathogenesis of Rett Syndrome and Study of the Role of Mecp2 Protein in Neuronal Function" (THESIS/DISSERTATION)
2005/05/02 - 2005/05/13 Concluded	Laboratory Animal Science, Category C (Pós-Graduação) Federation of Laboratory Animal Science Associations (FELASA), United Kingdom
1996/09/20 - 2000/11/16 Concluded	Biologia (Licenciatura) Major in Científico Universidade do Porto Faculdade de Ciências, Portugal	15

Affiliation

Science

	Category Host institution	Employer
2019/04/08 - Current	Auxiliary Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/09/01 - 2017/06/30	Contracted Researcher (Research)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany
	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany
2008/01/01 - 2013/06/30	Postdoc (Research)	Centre de Regulació Genòmica, Spain
	Centre de Regulació Genòmica, Spain
2002/02/20 - 2007/12/20	Researcher (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal (...)
2002/08 - 2002/09	Visiting Researcher (Research)	Universidade Estadual de Campinas, Brazil
	Universidade Estadual de Campinas, Brazil
2000/11/01 - 2002/02/19	Researcher (Research)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/06 - 2001/10	Visiting Researcher (Research)	University of Cambridge Addenbroke's Hospital, United Kingdom
	University of Cambridge Addenbroke's Hospital, United Kingdom
1999/03/01 - 2000/09/30	Research Trainee (Research)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2022/09/01 - Current	Invited Assistant Professor (University Teacher)	Escola Superior de Enfermagem de Coimbra, Portugal

2021/09/01 - 2022/01/31	Invited Assistant Professor (University Teacher)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Other Careers

	Category Host institution	Employer
2018/09/17 - 2019/04/05	Professor do ensino básico e secundário (Professor do ensino básico e secundário)	Associação Semear Talentos, Portugal

Positions / Appointments

	Category Host institution	Employer
2010/09/01 - 2012/07/31	Chair of the student's committee	8th FENS Forum, Spain
	Spanish Society of Neuroscience, Spain
2008/09/01 - 2009/07/31	Member of the Young Neuroscientist's committee	XIII Forum of the Sociedad Española de Neurociencias (SENC), Spain

Projects

Grant

	Designation	Funders
2019/10/08 - Current	BrainHealth 2020 - Early detection, Neuromodulation and Advanced Therapies to Brain Disorders. CENTRO-01-0145-FEDER-000008 Research Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	PT2020-CENTRO 2020 (FEDER) Ongoing
2016/12/30 - Current	Maternal Defence, Reward and Olfaction: Neurobiology of Social Behaviours Guided by Pheromones in Mice BFU2016-77691-C2-1-P Other Facultat De Ciencies De La Salut, Universitat Jaume I, Spain	Ministry of Economy, Industry and Competitiveness Concluded
2025/01/01 - 2028/12/31	Neuroendocrine basis of atypical social and anxiety-like behaviour in Mecp2 deficient mice, model of Rett syndrome CIAICO/2023 Researcher Universitat de València, Spain	Ongoing
2020 - 2023	Structural plasticity in the olfactory system: impact of maternity, early stress and Mecp2 deficiency PID2019-107322GB-C22 Other Universitat de València, Spain	Gobierno de España Ministerio de Ciencia e Innovación Ongoing
2015/03/01 - 2018/03/30	Preclinical approaches towards therapeutic intervention for fragile X premutation carriers 01GM1505 Other Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany	Bundesministerium fur Bildung und Forschung Dienststelle Bonn Concluded
2016 - 2018	Neurobiology of social behaviour. Experimental study of the aggressive and autistic brain in mice models UJI-B2016-45 Other Facultat De Ciencies De La Salut, Universitat Jaume I, Spain	Universitat Jaume I Concluded
2015 - 2017	Neurobiology and Neurocognitive function in mousse models of Rasopathies. FKZ 1GM1519A Other Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany	Bundesministerium fur Bildung und Forschung Dienststelle Bonn Concluded
2012/07/01 - 2013/06/30	Knockdown of HAS 21-syntenic miRNAs in Ts65Dn mice by adeno-associated viral vectors. Consequences on hippocampus-dependent phenotypes 01_CF Post-doc Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain	Fondation Jérôme Lejeune Concluded
2011/01/01 - 2012/06/30	Molecular bases of the functional role of the alternative splicing Ntrk3 WT and insert isoforms in learning and memory processes that rely on the cortico-hippocampal circuit. 07_M Post-doc Fellow Centro de Regulación Genómica, Spain	Fundación Ramon Areces Concluded
2002 - 2005	Clinical, epidemiological and genetic study of Rett syndrome in Portugal. POCTI 41416/2001 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2001 - 2003	Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES). Genomic screen of 6000 markers in the pooled Portuguese sample. 057097 Research Technician Fellow Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Addenbrooke's Hospital Department of Neurology, United Kingdom	Welkome Trust (UK) Concluded

Contract

	Designation	Funders
2019/03/01 - Current	Role of NT3/TrkC in the regulation of fear 85/18 Principal investigator Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação Bial Ongoing
2021/01/01 - 2025/12/31	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024/03/01 - 2025/02/28	Drug screening - ProRett 2024/1 Co-Principal Investigator (Co-PI) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Pro RETT Ricerca Ongoing
2021/07/01 - 2023/06/30	An investigation on the MeCP2-early life stress interaction effects in anxiety sensitivity later in life in a mouse model of Rett syndrome 2046/2021 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fondation Jérôme Lejeune Ongoing
2021/03/01 - 2021/05/31	Regulation of mitochondria fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis PTDC/MED-NEU/3736/2020 co-Principal Investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/10/07 - 2021/04/06	The endocannabinoid system and Rett syndrome: neuroanatomical, neurochemical and behavioural analyses 2/2019 Principal investigator Universitat de Valencia Facultat de Ciències Biològiques, Spain Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	FinRett Ongoing
2013/09/01 - 2016/04/30	Experimental approaches towards therapeutic intervention for Fragile X-associated Tremor Ataxia Syndrome 01GM1302 Principal investigator Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany	Bundesministerium fur Bildung und Forschung Dienststelle Bonn Concluded
2012/07/01 - 2013/06/30	Phenotypic rescue of the Ts65Dn Down syndrome mouse model using a miRNA decoy approach. U716 Post-doc Fellow Centre de Regulació Genòmica, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain	Centro de Investigación Biomédica en Red de Enfermedades Raras Concluded
2008/01/01 - 2010/12/31	Understanding the impact of panic attacks on brain systems involved in the pathophysiology of panic disorder: cognitive, neural and molecular mechanisms. SFRH/BPD/28555/2006 Post-doc Fellow Centre de Regulació Genòmica, Spain	Fundação para a Ciência e a Tecnologia Concluded
2002/12/01 - 2006/11/30	Study of Rett syndrome pathogenesis and the role of MeCP2 protein in the neuronal function. SFRH/BD/9111/2002 PhD Student Fellow Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference abstract	Martínez-Rodríguez, Elena; Andretta, Emanuela; Mele, Miranda; Santos, M. "Role of NT3-TrkC in the regulation of fear". Paper presented in 2020 BIAL Foundation symposium - Behind and Beyond the Brain, Porto, 2020. Pinto-Basto, José; Santos, Mónica; Rio, Maria Edite; Sá, MJ; Valença, Ângela; Sá, Alfredo; Dinis, José; et al. "Rastreio do genoma e identificação de loci associados à esclerose múltipla em doentes portugueses". Paper presented in Congresso de Neurologia, Espinho, 2002. Published Santos, Mónica; Costa, MC; Rio, Maria Edite; Sá, MJ; Carvalho, Marta; Valença, Ângela; Sá, Alfredo; et al. "Susceptibilidade e progressão da esclerose múltipla em doentes Portugueses - estudo do papel dos loci APOE e SCA2". Paper presented in Congresso de Neurologia, Espinho, 2002. Published Santos, Mónica; Costa, MC; Rio, Maria Edite; Sá, MJ; Carvalho, Marta; Valença, Ângela; Sá, Alfredo; et al. "Study of the ApoE and SCA2 Loci in Multiple Sclerosis Patients of Portuguese Origin". Paper presented in 54th Annual Meeting of AAN, Denver, 2002. Published
Conference poster	Ferrer PS,; Pardo-Garcia, Josep; Martínez-Rodríguez E, ; Santos, M; Enrique Lanuza; Agustín-Pavón, Carmen. Corresponding author: Agustín-Pavón, Carmen. "MeCP2 deficiency impairs the maturation process of doublecortin neurons in the olfactory cortex". Paper presented in 11th IBRO World Congress of Neuroscience, 2023. Primo Hernando, L; Martínez-Rodríguez E, ; Santos, M; Agustín-Pavón, Carmen; Torres-Pérez, JV. "Impact of an early-life adverse experience on microglia activation in the periaquedutal gray of adolescent Mecp2-heterozygous female mice". Paper presented in 11th IBRO World Congress of Neuroscience, 2023. Masella, Gianluca; Silva, Francisca; Mele, M; Duarte, Carlos B.; Santos, M. "NT-3/TrkC-dependent regulation of NMDA receptors: implications for fear extinction". Paper presented in ISN-ESN Meeting, 2023. Masella, Gianluca; Francisca Silva; Corti, Elisa; Madeira, Maria Francisca; Ferreira, Samira G.; Tomé, Angelo R.; Rodrigo A. Cunha; Carlos B. Duarte; Santos, Monica. "NT3/TrkC signaling regulate contextual fear extinction and amygdalar long-term potentiation, with a mechanism dependent on GluN2B subunit of NMDA receptors". Paper presented in ISN-ESN 2023 Meeting, 2023. Madeira, Maria Francisca; Masella, Gianluca; Silva, Francisca; Leitão, Ricardo; Abellán-Álvaro, Maria; Teruel, A.; Agustín-Pavón, Carmen; Santos, Mónica. "Early-life stress and MeCP2 interaction effects on anxiety neurocircuitry". Paper presented in FENS Regional Meeting, 2023. Rodrigues, Beatriz; Leitão, Ricardo Alexandre; Santos, Monica; Silva, Mariline; Paulo César Silva Pinheiro; Carvalho, Ana Luisa. "REGULATION OF PFC SYNAPTIC FUNCTION AND BEHAVIOR BY CHRONIC STRESS-INDUCED MICRORNA-186-5P". Paper presented in FENS Regional meeting 2023, 2023. Masella, Gianluca; Francisca Silva; Mele, Miranda; Duarte, Carlos B.; Santos, Monica. Corresponding author: Santos, Monica. "Neurotrophin-3/TrkC contribution to fear extinction and regulation of glutamatergic synapses". Paper presented in FENS Forum 2022, 2022. Francisca Silva ; Masella, Gianluca; Elena Martínez-Rodríguez; Andretta, Emanuela; Mele, Miranda; Duarte, Carlos B.. "Role of NT3/TrkC in the regulation of fear.". Paper presented in 13th Symposium of Bial Foundation “Behind and Beyond the Brain”, 2022. Francisca Silva ; Masella, Gianluca; Elena Martínez-Rodríguez; Santos, Monica. Corresponding author: Santos, Monica. "Amygdalar TrkC activation is associated with successful fear extinction performance". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Masella, Gianluca; Andretta, Emanuela; Mele, Miranda; Duarte, Carlos B.; Santos, Monica. Corresponding author: Santos, Monica. "NT3/TrkC signaling controls the composition and the synaptic abundance of AMPA and NMDA receptors.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Santos, Monica; María Abellán-Álvaro; Stork, O; Agustín-Pavón, Carmen. Corresponding author: Santos, Monica. "MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Elena Martínez-Rodríguez; Anabel Forte; Enrique Lanuza; Santos, Monica; Agustín-Pavón, Carmen. Corresponding author: Agustín-Pavón, Carmen. "Maternal separation decreases the expression of doublecortin in the olfactory system of both Mecp2-heterozygous female mice and their healthy controls.". Paper presented in 19th Meeting of the Spanish Society for Neuroscience, 2021. Sevilla-Ferrer, Paloma; Pardo-Garcia, Josep; Elena Martínez-Rodríguez; María Abellán-Álvaro; Santos, Monica; Enrique Lanuza; Agustín-Pavón, Carmen. Corresponding author: Agustín-Pavón, Carmen. "The increase in doublecortin immature neurons in the olfactory cortex is linked to symptom onset in a mouse model of Rett syndrome.". Paper presented in 19th Meeting of the Spanish Society for Neuroscience, 2021. Caliskan, Gursel; Kul, Emre; Hukema, Renate K.; Willemsen, Rob; Santos, Monica; Oliver Stork. Corresponding author: Oliver Stork. "Heightened anxiety and ventral hippocampal gamma oscillations in an inducible mouse model of FMR1 premutation". Paper presented in FENS virtual Forum, 2020. Martínez-Rodríguez, Elena; Foiani, Cristina; Martín-Sánchez, Ana; Martínez-Garcia, Fernando; Lanuza, Enrique; Santos, M; Agustín-Pavón, Carmen. "Postnatal neurogenesis in the olfactory bulbs of a mouse model of Rett syndrome". Paper presented in 2nd symposium of the Spanish Network of Adult Neurogenesis (RENA), 2019. Kul, Emre; Hukema, Renate K.; Willemsen, Rob; Santos, M; Stork, Oliver. "Progression of FXTAS Reveals Sensorimotor Deficiencies upon Extended Expression of the CGG-Premutation". Paper presented in 11th FENS Forum of Neuroscience, 2018. Kul, Emre; Castro, Hoanna; Deipenbrock, Leandra; Ribeiro, Juliana; Buijsen, Ronald A.M.; Severijnen, Lies-Anne W.F.M.; Willemsen, Rob; et al. "Critical Time Windows of Premutation Expression in FXTAS Phenotype.". Paper presented in 10th FENS Forum of Neuroscience, 2016. Santos, M; D'Amico, Davide; Gener, Thomas; Sanchez-Vives, M. V.. "Infralimbic NT3 infusion restores fear extinction memory impairment in a mouse model of panic disorder". Paper presented in XIV Meeting of the Portuguese Society for Neuroscience, 2015. Santos, M; D'Amico, Davide; Gener, Thomas; Sanchez-Vives, M. V.; Dierssen, Mara. "Infralimbic NT3 infusion restores fear extinction memory impairment in a mouse model of panic disorder". Paper presented in International Meeting of Learning and Memory: Cellular and Systemic Views, 2015. Santos, M; D'Amico, Davide; Dierssen, Mara. "Altered hippocampus-dependent cognitive profile and fear circuit activation in a transgenic mouse that overexpresses TrkC: insight on panic disorder". Paper presented in ESF-FENS conferences on The Dynamic Brain: The Neurobiology of Emotion, 2012. Santos, M; D'Amico, Davide; Padrell, Sara; Dierssen, Mara. "In vivo TrkC overexpression induces hyperexcitability and strengthens hippocampus-dependent fear memories". Paper presented in 8th FENS Forum of Neuroscience, 2012. Santos, M; D'Amico, Davide; Vegue, Marina; Dierssen, Mara. "Hippocampal overexcitability in a panic disorder mouse model.". Paper presented in 40th Society for Neuroscience, 2010. Molas, Susanna; Gallego, Xavier; Santos, M; Dierssen, Mara. "A mouse model for nicotine dependence: The overexpression of the human genomic cluster CHRNA3/A5/B4". Paper presented in 7th FENS Forum of Neuroscience, 2010. D'Amico, Davide; Santos, M; Spadoni, Ornella; Dierssen, Mara. "Hippocampal alterations associated with fear memories in TgNTRK3 mouse, a model of panic disorder". Paper presented in EMBL Workshop on Translating Behaviour: Bridging Clinical and Animal Model Research, 2009. Molas, Susanna; Gallego, Xavier; Santos, M; Dierssen, Mara. "The implication of nicotine in anxious behaviour and cognition converge on the human genetic cluster CHRNA3/CHRNA5/CHRNB4: evidences from a transgenic model". Paper presented in VII Experimental Biology Symposium, 2008. Santos, M; Teixeira-Castro, Andreia; Silva-Fernandes, Anabela; Tavares, Hugo; Sousa, Nuno; Maciel, Patrícia. "Absence of MeCP2 increases postnatal dentate gyrus cell proliferation in a mouse model of Rett syndrome.". Paper presented in 6th FENS Forum of European Neuroscience, 2008. Santos, M; Coutinho, A. M.; Yan, Jin; Yang, C; Feng, J; Vicente, Astrid; Sommer, Steve S.; Maciel, Patrícia. "Analysis of the 3’ UTR of the MECP2 gene in patients with clinical diagnosis of Rett syndrome and mental retardation". Paper presented in 56th annual meeting of The American Society of Human Genetics, 2006. Santos, M; Temudo, Teresa; Carrilho, Isabel; Gaspar, I; Barbot, Clara; Medeira, Ana; Cabral, Helena; et al. "Genetic study of boys with a Rett syndrome-like phenotype: analysis of the MECP2, NLGN3 and NLGN4 genes.". Paper presented in 7th Annual Rett syndrome Symposium, 2006. Santos, M; Venâncio, Margarida; Barbot, Clara; Medeira, Ana; Cabral, Helena; Cabral, P.; Carrilho, Isabel; et al. "P56. Genetic study of boys with a Rett syndrome-like phenotype: analysis of the MECP2, NLGN3 and NLGN4 genes". Paper presented in 9th Annual Meeting of the Portuguese Society of Human Genetics, 2005. Santos, M; Temudo, Teresa; Barbot, Clara; Medeira, Ana; Cabral, Helena; Cabral, P.; Carrilho, Isabel; et al. "P2727, 489. Male patients with Rett-like phenotype do not present mutations in the MECP2, NLGN3 and NLGN4 genes". Paper presented in 54th Annual Meeting of The American Society of Human Genetics, 2004. Temudo, Teresa; Santos, M; Dias, Karen; Barbot, Clara; Cabral, P.; Moreira, Ana; Carrilho, Isabel; et al. "P2728, 489. Genotype-phenotype correlations in portuguese patients with Rett syndrome". Paper presented in 54th Annual Meeting of The American Society of Human Genetics, 2004. Temudo, Teresa; Santos, M; Dias, Karen; Barbot, Clara; Cabral, P.; Moreira, Ana; Carrilho, Isabel; et al. "Genotype-phenotype correlations in portuguese patients with Rett syndrome". Paper presented in 54th Annual Meeting of The American Society of Human Genetics, 2004. Santos, M; Temudo, Teresa; Barbot, Clara; Medeira, Ana; Cabral, Helena; Cabral, P.; Carrilho, Isabel; et al. "Male patients with Rett-like phenotype do not present mutations in the MECP2, NLGN3 and NLGN4 genes". Paper presented in 54th Annual Meeting of The American Society of Human Genetics, 2004. Ferro, Anabela; Castro, Maria-José; Sousa, Alda; Lemos, Carolina; Santos, M; Silveira, Isabel; Pereira-Monteiro, J.; Sequeiros, Jorge. "P16. The C677T MTHFR polymorphism is not a genetic risk factor for migraine in the portuguese population". Paper presented in Genetics of complex traits and isolated populations, 2003. Santos, M; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, M.C.; Valença, A.; Sá, André; et al. "P0913. Susceptibility and disease progression in Portuguese patients with multiple sclerosis: study of the role of APOE and SCA2 loci". Paper presented in European Congress of Human Genetics, 2002. Santos, M; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, M.C.; Valença, A.; Sá, André; et al. "Susceptibility and disease progression in Portuguese patients with multiple sclerosis: study of the role of APOE and SCA2 loci". Paper presented in European Congress of Human Genetics, 2002. Santos, M; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, M.C.; Valença, A.; Sá, André; et al. "P01.138. Study of the APOE and SCA2 loci in multiple sclerosis patients of Portuguese origin". Paper presented in 54th Annual Meeting of the American Academy of Neurology, 2002. Costa, Maria do Carmo; Santos, Cláudia; Ferro, Anabela; Santos, M; Sequeiros, Jorge; Maciel, Patrícia. "Identification of 3 new intragenic polymorphisms in the MJD1 gene and study of its frequency in the portuguese population". Paper presented in 5th Annual Meeting of the Portuguese Society of Human Genetics, 2001. Costa, Maria do Carmo; Santos, Cláudia; Ferro, Anabela; Santos, M; Sequeiros, Jorge; Maciel, Patrícia. "P1373. Identification of three novel polymorphisms in the MJD1 gene and their frequency study in a Portuguese population". Paper presented in 51st Annual Meeting of The American Society of Human Genetics, 2001. Costa, Maria do Carmo; Santos, Cláudia; Ferro, Anabela; Santos, M; Sequeiros, Jorge; Maciel, Patrícia. "Identification of three novel polymorphisms in the MJD1 gene and their frequency study in a Portuguese population". Paper presented in 51st Annual Meeting of The American Society of Human Genetics, 2001.
Journal article	Ventura, Rossella; Di Segni, Matteo; Santos, Mónica; Agustín-Pavón, Carmen; Torres-Pérez, Jose V.. "Editorial: Long-lasting neurobehavioral effects of early-life events". Frontiers in Neuroscience 18 (2024): http://dx.doi.org/10.3389/fnins.2024.1509723. 10.3389/fnins.2024.1509723 Beatriz Rodrigues; Ricardo A. Leitão; Mónica Santos; Alexander Trofimov; Mariline Silva; Ângela S. Inácio; Mónica Abreu; et al. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". Molecular Psychiatry (2024): https://doi.org/10.1038/s41380-024-02715-1. 10.1038/s41380-024-02715-1 Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al. "The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". Molecular Psychiatry (2024): http://dx.doi.org/10.1038/s41380-024-02412-z. In press • 10.1038/s41380-024-02412-z Francisca Silva; Gianluca Masella; Maria Francisca Madeira; Carlos B. Duarte; Mónica Santos. "TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory". Molecular Neurobiology (2023): https://doi.org/10.1007/s12035-023-03292-0. 10.1007/s12035-023-03292-0 María Abellán-Álvaro; Oliver Stork; Carmen Agustín-Pavón; Mónica Santos. "MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice". Journal of Neurodevelopmental Disorders (2021): https://doi.org/10.1186/s11689-021-09409-7. 10.1186/s11689-021-09409-7 Elena Martínez-Rodríguez; Ana Martín-Sánchez; Emre Kul; Aparajita Bose; Francisco José Martínez-Martínez; Oliver Stork; Fernando Martínez-García; et al. "Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour". Brain Structure and Function 225 7 (2020): 2219-2238. https://doi.org/10.1007/s00429-020-02122-6. 10.1007/s00429-020-02122-6 Martínez-Rodríguez, Elena; Martín-Sánchez, Ana; Coviello, Simona; Foiani, Cristina; Kul, Emre; Stork, Oliver; Martínez-García, Fernando; et al. "Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system". Brain Structure and Function 224 4 (2019): 1647-1658. http://dx.doi.org/10.1007/s00429-019-01860-6. Published • 10.1007/s00429-019-01860-6 Castro, Hoanna; Kul, Emre; Buijsen, Ronald A.M.; Severijnen, Lies-Anne W.F.M.; Willemsen, Rob; Hukema, Renate K.; Stork, Oliver; Santos, Mónica. "Selective rescue of heightened anxiety but not gait ataxia in a premutation 90CGG mouse model of Fragile X-associated tremor/ataxia syndrome". Human Molecular Genetics 26 11 (2017): 2133-2145. http://dx.doi.org/10.1093/hmg/ddx108. Published • 10.1093/hmg/ddx108 Altmüller F; Pothula S; Annamneedi A; Nakhaei-Rad S; Montenegro-Venegas C; Pina-Fernández E; Marini C; et al. "Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.". PLoS genetics (2017): http://europepmc.org/abstract/med/28346493. Open access • 10.1371/journal.pgen.1006684 Altmüller, F.; Pothula, S.; Annamneedi, A.; Nakhaei-Rad, S.; Montenegro-Venegas, C.; Pina-Fernández, E.; Marini, C.; et al. "Erratum: Correction: Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy (PLoS genetics (2017) 13 3 (e1006684))". PLoS genetics 13 6 (2017): e1006843-e1006843. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054771599&partnerID=MN8TOARS. Open access • 10.1371/journal.pgen.1006843 D'Amico, Davide; Gener, Thomas; de Lagrán, Maria Martínez; Sanchez-Vives, Maria V; Santos, Mónica; Dierssen, Mara. "Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear". Neuropsychopharmacology 42 2 (2016): 462-472. http://dx.doi.org/10.1038/npp.2016.154. Open access • Published • 10.1038/npp.2016.154 Foote, Molly; Arque, Gloria; Berman, Robert F.; Santos, Mónica. "Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) Motor Dysfunction Modeled in Mice". The Cerebellum 15 5 (2016): 611-622. http://dx.doi.org/10.1007/s12311-016-0797-6. Published • 10.1007/s12311-016-0797-6 Bofill-De Ros, Xavier; Santos, Mónica; Vila-Casadesús, Maria; Villanueva, Eneko; Andreu, Nuria; Dierssen, Mara; Fillat, Cristina. "Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges". BMC Genomics 16 1 (2015): http://dx.doi.org/10.1186/s12864-015-2160-6. Open access • Published • 10.1186/s12864-015-2160-6 Santos, Mónica; D’Amico, Davide; Dierssen, Mara. "From neural to genetic substrates of panic disorder: Insights from human and mouse studies". European Journal of Pharmacology 759 (2015): 127-141. http://dx.doi.org/10.1016/j.ejphar.2015.03.039. Published • 10.1016/j.ejphar.2015.03.039 Fillat, C.; Bofill-De Ros, X.; Santos, M.; Martín, E.D.; Andreu, N.; Villanueva, E.; D'Amico, D.; Dierssen, M.; Altafaj, X.. "Identification of key genes involved in Down syndrome pathogenesis by gene therapy,Identificación de genes clave implicados en el síndrome de Down mediante terapia génica". SD Revista Medica Internacional sobre el Sindrome de Down 18 2 (2014): 21-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940262370&partnerID=MN8TOARS. Published • 10.1016/S1138-2074(14)70049-1 Santos, M.; D'Amico, D.; Spadoni, O.; Amador-Arjona, A.; Stork, O.; Dierssen, M.. "Hippocampal Hyperexcitability Underlies Enhanced Fear Memories in TgNTRK3, a Panic Disorder Mouse Model". Journal of Neuroscience 33 38 (2013): 15259-15271. http://dx.doi.org/10.1523/jneurosci.2161-13.2013. Published • 10.1523/jneurosci.2161-13.2013 Temudo, Teresa; Santos, Mónica; Ramos, Elisabete; Dias, Karin; Vieira, José Pedro; Moreira, Ana; Calado, Eulália; et al. "Rett syndrome with and without detected MECP2 mutations: An attempt to redefine phenotypes". Brain and Development 33 1 (2011): 69-76. http://dx.doi.org/10.1016/j.braindev.2010.01.004. Published • 10.1016/j.braindev.2010.01.004 Santos, M.; Summavielle, T.; Teixeira-Castro, A.; Silva-Fernandes, A.; Duarte-Silva, S.; Marques, F.; Martins, L.; et al. "Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome". Neuroscience 170 2 (2010): 453-467. http://dx.doi.org/10.1016/j.neuroscience.2010.07.010. Published • 10.1016/j.neuroscience.2010.07.010 Santos, Mónica; Temudo, Teresa; Kay, Teresa; Carrilho, Inês; Medeira, Ana; Cabral, Helena; Gomes, Roseli; et al. "Mutations in the MECP2 Gene Are Not a Major Cause of Rett Syndrome-Like or Related Neurodevelopmental Phenotype in Male Patients". Journal of Child Neurology 24 1 (2009): 49-55. http://dx.doi.org/10.1177/0883073808321043. Published • 10.1177/0883073808321043 Carvalho, A.; Santos, M.; Maciel, P.; Rodrigues, F.. "T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population". Multiple Sclerosis Journal 14 4 (2008): 550-552. http://dx.doi.org/10.1177/1352458507084594. Published • 10.1177/1352458507084594 Ferro, Anabela; Castro, Maria-José; Lemos, Carolina; Santos, Mónica; Sousa, Alda; Pereira-Monteiro, José; Sequeiros, Jorge; Maciel, Patrícia. "The C677T Polymorphism inMTHFRIs Not Associated with Migraine in Portugal". Disease Markers 25 2 (2008): 107-113. http://dx.doi.org/10.1155/2008/178679. Published • 10.1155/2008/178679 Santos, Mónica; Yan, Jin; Temudo, Teresa; Oliveira, Guiomar; Vieira, José Pedro; Fen, Jinong; Sommer, Steve; Maciel, Patrícia. "Analysis of Highly Conserved Regions of the 3’UTR of MECP2 Gene in Patients with Clinical Diagnosis of Rett Syndrome and Other Disorders Associated with Mental Retardation". Disease Markers 24 6 (2008): 319-324. http://dx.doi.org/10.1155/2008/738401. Published • 10.1155/2008/738401 Venâncio, Margarida; Santos, Mónica; Pereira, Susana Aires; Maciel, Patrícia; Saraiva, Jorge M. "An explanation for another familial case of Rett syndrome: maternal germline mosaicism". European Journal of Human Genetics 15 8 (2007): 902-904. http://dx.doi.org/10.1038/sj.ejhg.5201835. Published • 10.1038/sj.ejhg.5201835 Temudo, T.; Oliveira, P.; Santos, M.; Dias, K.; Vieira, J.; Moreira, A.; Calado, E.; et al. "Stereotypies in Rett syndrome: Analysis of 83 patients with and without detected MECP2 mutations". Neurology 68 15 (2007): 1183-1187. http://dx.doi.org/10.1212/01.wnl.0000259086.34769.78. Published • 10.1212/01.wnl.0000259086.34769.78 Santos M; Silva-Fernandes A; Oliveira P; Sousa N; Maciel P; Santos, M.; Silva-Fernandes, A.; et al. "Evidence for abnormal early development in a mouse model of Rett syndrome.". Genes, Brain and Behavior 6 3 (2007): 277-286. http://europepmc.org/abstract/med/16848781. Published • 10.1111/j.1601-183X.2006.00258.x Coutinho, Ana M.; Oliveira, Guiomar; Katz, Cécile; Feng, Jinong; Yan, Jin; Yang, Chunmei; Marques, Carla; et al. "MECP2 coding sequence and 3'UTR variation in 172 unrelated autistic patients". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B 4 (2007): 475-483. http://dx.doi.org/10.1002/ajmg.b.30490. Published • 10.1002/ajmg.b.30490 Ban, M.; Booth, D.; Heard, R.; Stewart, G.; Goris, A.; Vandenbroeck, K.; Dubois, B.; et al. "Corrigendum to "Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans" [J. Neuroimmunol. 179 (2006) 108-116] (DOI:10.1016/j.jneuroim.2006.06.003)". Journal of Neuroimmunology 189 1-2 (2007): 175-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548554091&partnerID=MN8TOARS. Open access • 10.1016/j.jneuroim.2007.08.003 The GAMES Collaborative Group. "Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans". Journal of Neuroimmunology 179 1-2 (2006): 108-116. http://dx.doi.org/10.1016/j.jneuroim.2006.06.003. Published • 10.1016/j.jneuroim.2006.06.003 Santos, M.; Coelho, P. A.; Maciel, P.. "Chromatin remodeling and neuronal function: exciting links". Genes, Brain and Behavior 5 (2006): 80-91. http://dx.doi.org/10.1111/j.1601-183x.2006.00227.x. Published • 10.1111/j.1601-183x.2006.00227.x Burwick, R. M.; Ramsay, P. P.; Haines, J. L.; Hauser, S. L.; Oksenberg, J. R.; Pericak-Vance, M. A.; Schmidt, S.; et al. "APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers". Neurology 66 9 (2006): 1373-1383. http://dx.doi.org/10.1212/01.wnl.0000210531.19498.3f. Published • 10.1212/01.wnl.0000210531.19498.3f Shi, Jinxiu; Shibayama, Akane; Liu, Qiang; Nguyen, Vu Q.; Feng, Jinong; Santos, Monica; Temudo, Teresa; Maciel, Patricia; Sommer, Steve S.. "Detection of heterozygous deletions and duplications in the MECP2 gene in Rett syndrome by Robust Dosage PCR (RD-PCR)". Human Mutation 25 5 (2005): 505-505. http://dx.doi.org/10.1002/humu.9338. Published • 10.1002/humu.9338 Santos, Mónica; do Carmo Costa, Maria; Rio, Maria Edite; Sá, Maria José; Monteiro, Marta; Valença, Angela; Sá, Alfredo; et al. "Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin". Multiple Sclerosis Journal 10 2 (2004): 153-157. http://dx.doi.org/10.1191/1352458504ms998oa. Published • 10.1191/1352458504ms998oa Santos, M.; Pinto-Basto, J.; Rio, M.E.; Sá, M.J.; Valença, A.; Sá, A.; Dinis, J.; et al. "A whole genome screen for association with multiple sclerosis in Portuguese patients". Journal of Neuroimmunology 143 1-2 (2003): 112-115. http://dx.doi.org/10.1016/j.jneuroim.2003.08.023. Published • 10.1016/j.jneuroim.2003.08.023
Preprint	Gianluca Masella; Francisca Silva; Elisa Corti; Garokoitz Azkona; Maria Francisca madeira; Ângelo Tomé; Samira Ferreira; et al. "Amygdalar NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". 2023. https://doi.org/10.21203/rs.3.rs-3059690/v1. 10.21203/rs.3.rs-3059690/v1 Ana Luisa Carvalho; Beatriz Rodrigues; Ricardo Leitão; Mónica Santos; Alexander Trofimov; Mariline Silva; Ângela Inácio; et al. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". 2023. https://doi.org/10.21203/rs.3.rs-3405749/v1. 10.21203/rs.3.rs-3405749/v1
Thesis / Dissertation	Santos, Mónica Joana Pinto dos. "Pathogenesis of Rett syndrome and study of the role of MeCP2 protein in neuronal function.". PhD, 2007. http://hdl.handle.net/10216/7217.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/11/17	NT3-TrkC System in the Regulation of Fear Memories.	Institute of Neuroscience Seminars Institute of Neuroscience, Autonomous University of Barcelona (Barcelona, Spain)
2023/10/30	NT3-TrkC System in the Regulation of Fear Memories.	Cajal Course Advance Techniques in Synapse Biology Cajal Course (Bordeaux, France)
2023/10/18	The Science Behind Fear Memories.	DCV talks Department of Life Sciences, Faculty of Science and Technology, University of Coimbra (Coimbra, Portugal)
2023/04/15	A Ciência por Detrás do Medo \| The Science Behind Fear	meet.Lab Associação de Estudantes de Biologia (Coimbra, Portugal)
2018/05/10	Lack of MeCP2 leads to na increase of immature neurons in the olfactory system.	VII Olfactory Journeys Spanish Olfactory Network (La Franca, Spain)
2016/04/15	Critical Time Windows of Premutation Expression: FXTAS and Other Phenotypes.	Research Seminars in Biomedicine Universitat Jaume I (Castelló de la Plana, Spain)
2016/03/04	Role of the NT3/TrkC system in the formation and extinction of (pathological) fear memories.	CNC weekly seminars Universidade de Coimbra Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2015/10/16	Critical Time Windows of Premutation Expression: FXTAS and Other Phenotypes	CNC weekly seminars Universidade de Coimbra Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2015/10/01	Behavioral characterization of an inducible mouse model of FXTAS: critical time windows of premutation expression.	2nd FMR1 premutation meeting (Sitges, Spain)
2014/12/18	Role of the NT3/TrkC system in the formation and extinction of (pathological) fear memories.	Neuroscience seminars Life and Health Sciences Research Institute (ICVS) (Braga, Portugal)
2013/05/31	Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.	XIII Meeting of the Portuguese Society for Neuroscience Portuguese Society for Neuroscience (Luso, Portugal)
2013/03/01	Antagonizing HSA21-synthenic miRNAs effects in the Ts65Dn mouse model of Down syndrome by a lentiviral miRNA sponge strategy.	VI CIBERER Annual Meeting CIBERER (San Lorenzo del Escorial, Spain)
2013/02/26	Contribution of the hippocampus to exaggerated fear in TgNTRK3, a mouse model of panic disorder.	Neuroscience seminars Leibniz Institute (Magdeburg, Germany)
2009/09/15	Understanding the Impact of Panic Attacks on Brain Systems Involved in the Pathophysiology of Panic Disorder.	XII Meeting of the Spanish Society for Neuroscience Spanish Society for Neuroscience (Tarragona, Spain)
2009/03/08	Characterization of the hippocampal microcircuit in a mouse model of panic disorder.	5th Cajal Winter Conference Spanish Society for Neurosciences (Benasque, Spain)
2008/10/10	Age- and region-specific disturbances of monoaminergic systems in the brain of MECP2-null mice.	6th World Rett Syndrome Congress Rett syndrome Research Foundation (Paris, France)
2008/03/03	Delayed achievement of developmental milestones in a mouse model of Rett syndrome.	4th Cajal Winter Conference Spanish Society of Neuroscience (Benasque, Spain)
2005/11/15	Delayed achievement of developmental milestones in a mouse model of Rett syndrome.	35th Annual meeting of the Society for Neuroscience Society for Neuroscience (Washington, United States)
2005/10/13	Rett syndrome-like male patients: study of the MECP2, NLGN3 and NLGN4 genes.	2nd Iberian Meeting of Neuropediatrics IV Meeting of the Portuguese Society of Neuropediatrics (Estoril, Portugal)
2005/10/13	Study of postnatal neurodevelopmental hallmarks in a mouse model of Rett syndrome.	2nd Iberian Meeting of Neuropediatrics IV Meeting of the Portuguese Society of Neuropediatrics (Estoril, Portugal)
2002/10/15	Association study of multiple sclerosis in Portuguese patients: whole genome screen using 6,000 microsatellite markers.	52nd Meeting of American Society of Human Genetics American Society of Human Genetics (Baltimore, United States)
2002/10/07	Genome screen and identification of loci associated to multiple sclerosis in Portuguese patients.	Congress of Neurology Portuguese Society of Neurology (Espinho, Portugal)
2002/10/07	Susceptibility and progression of multiple sclerosis in portuguese patients - study of the role of APOE and SCA2 loci.	Congress of Neurology Portuguese Society of Neurology (Espinho, Portugal)
2002/04/12	Candidate gene studies in Portuguese patients	Genetic Analysis of Multiple Sclerosis in Europeans (GAMES) Meeting GAMES consortium (Istanbul, Turkey)
2001/11/16	Clinical, Epidemiological and Genetic study of Rett syndrome in Portugal	Congress of Neurology Portuguese Society of Neurology (Lisboa, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - Current	The effects of early-life stress and MeCP2 interaction on neurobehavior. Bachelor in Cell and Molecular Biology, Department of Life Sciences. Supervisor	Cell and Molecular Biology (Degree) Universidade Nova de Lisboa, Portugal
2024 - Current	Validation of small molecule TrkC agonists in vitro in cultured cortical neurons. Supervisor	Biology (Degree) Universidade de Coimbra, Portugal
2023/09/01 - Current	Early-life stress influence on anxiety neurocircuitry and behavior: the contribution of MeCP2. Supervisor	Neurociências (PhD) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/01 - Current	Modulation of fear extinction by social hierarchy: behaviour, neuronal circuits and epigenetics Supervisor	Neurociências (PhD) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/09/01 - Current	NT3-TrkC system in contextual fear extinction and in the regulation of glutamatergic synapses Supervisor of Gianluca Masella	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/01 - 2024/02/26	NT3-TrkC system in the regulation of GABAergic synapses and inhibition/excitation balance. Supervisor	Neurobiologia (Master) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/09/01 - 2022/09/16	The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2 Supervisor of Maria Francisca Madeira	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09/01 - 2021/12/21	Dissection of NT3/TrkC intracellular signaling in the processing of fear Supervisor of Francisca Silva	Cellular and Molecular Biology (Master) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/02/01 - 2021/06/30	To investigate the contribution of neurotrophins to the aberrant maturation in the olfactory system of Mecp2-mutant mice Supervisor of João Videira	Biology (Degree) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/02/03 - 2020/12/18	Role of NT3-TrkC in fear learning and in the regulation of glutamatergic synapses Supervisor of Gianluca Masella	Neuroscience (Master) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Università degli Studi di Trieste, Italy
2015 - 2020	Reversibility of the pathology in a mouse model of Fragile X-associated tremor/ataxia syndrome: exploring time-dependence and intervention strategies. Co-supervisor of Emre Kul	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany
2014 - 2017	Characterization of postnatal neurodevelopment and behavioural cognition of a noonan syndrome mouse model. Co-supervisor of Maisaloon Sader	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany University of Haifa, Israel
2015 - 2016	Dissecting the role of MECP2 mutations: molecular tools and behavioural analysis. Co-supervisor of Leandra Deipenbrok	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany Universität Potsdam, Germany
2013 - 2013	Phenotype rescue in a down syndrome mouse model using a miRNA decoy method. Co-supervisor of Victoria Brugada	Universitat Pompeu Fabra, Spain Centro de Regulación Genómica, Spain
2009 - 2013	Fear memories in TgNTRK3 mice, a model of panic disorder: definition of mechanism and search for new therapeutical targets. Co-supervisor of Davide D'Amico	Universitat Pompeu Fabra, Spain Centro de Regulación Genómica, Spain
2008 - 2009	Understanding the impact of panic attacks on brain systems involved in the pathophysiology of panic disorder. Co-supervisor of Ornella Spadoni	Centro de Regulación Genómica, Spain Università degli Studi di Roma La Sapienza, Italy

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/12/20 - Current	Science with Books (Ciência com livros): What am I made of? Organs, Cells, Genes. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing their curiosity and critical thinking. (2019/12/20 - 2019/12/20) Workshop (Co-organisor)	Biblioteca Municipal de Santa Maria da Feira, Portugal
2019/10/26 - Current	Science with Books (Ciência com livros): Me and only me. DNA and the world around me. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing their curiosity and critical thinking. (2019/10/26 - 2019/10/26) Workshop (Co-organisor)	Biblioteca Municipal de Santa Maria da Feira, Portugal Biblioteca de Santa Maria da Feira, Portugal
2019 - Current	Science with Books (Ciência com livros): My brain and Our senses. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing curiosity and critical thinking. (2019/04/16 - 2019/04/17) Workshop (Co-organisor)	Biblioteca Municipal de Santa Maria da Feira, Portugal
2019 - Current	Science with Books (Ciência com livros): Colors. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing curiosity and critical thinking. (2021/02/20 - 2021/02/20) Workshop (Co-organisor)	Biblioteca Municipal de Santa Maria da Feira, Portugal
2022/04/06 - 2022/04/06	Mini-symposium: Animal Welfare meets the Bench. (2022/04/06 - 2022/04/06) Symposium (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/01/23 - 2020/01/24	Mini-symposium: The Neurobiology of Socio-Sexual Behavior. (2020/01/23 - 2020/01/24) Symposium (Co-organisor)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - 2009	In vivo models and tools in neuroscience research. (2009/09/16 - 2009/09/19) Workshop (President of the Organising Committee)	Spanish Neuroscience Society, Spain

Event participation

	Activity description Type of event	Event name Institution / Organization
2024/01/17 - 2024/01/17	Lecture to high school students (13-14 years) in the scope of the discipline 'Development and Citizenship'. Seminar	The effect of psychoactive substances in the brain Agrupamento de escolas do Cavaco, Portugal
2024/01/04 - 2024/01/04	Lecture for high school students (13-14 years) in the scope of the Discipline 'Development and Citizenship' Seminar	The effect of psychoactive substances in the brain Agrupamento de escolas da Corga do Lobão, Portugal
2021/02/20 - 2021/02/20	Public Outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Workshop	Science with books (Ciência com livros): Colors Biblioteca Municipal de Santa Maria da Feira, Portugal
2019/12/20 - 2019/12/20	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Workshop	Science with books (Ciência com livros): What am I made of: organs, cells, genes. Biblioteca de Santa Maria da Feira, Portugal
2019/11/25 - 2019/11/25	Public outreach. Hands on science activities at a 1st grade school Other	Science and Technology week Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/10/26 - 2019/10/26	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Workshop	Science with books (Ciência com livros): The one and only me. DNA and the world around me Biblioteca de Santa Maria da Feira, Portugal
2019/04/17 - 2019/04/17	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Workshop	Science with books (Ciência com livros): Our senses Biblioteca de Santa Maria da Feira, Portugal
2019/04/16 - 2019/04/16	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Workshop	Science with books (Ciência com livros): Our brain Biblioteca de Santa Maria da Feira, Portugal
2012/06/18 - 2012/06/18	Public outreach. What is Neuroscience? From its beginnings to the latest discoveries. Seminar	Cultural week at La Verneda adult's school Centre de Formació d'Adults La Verneda, Spain
2011/10/11 - 2011/10/11	Soft skills. Team management and leadership training for a successful scientific career. Workshop	Leading for Success in Science, refresher day Parc de Recerca Biomèdica de Barcelona, Spain
2010/06/03 - 2010/06/04	Continuous formation. Introductory course to electrophysiology techniques. Other	1st Introductory course to electrophysiology techniques: E2 and MEAs Aleria Biodevices, Spain
2010/05/08 - 2010/05/10	Soft skills. Team management and leadership training for a successful scientific career. Workshop	Leading for Success in Science Parc de Recerca Biomèdica de Barcelona, Spain
2010/03/12 - 2010/03/12	Public outreach. Seminar on Neuroscience at a 1st grade school. Seminar	Brain Awareness Week Spanish Society of Neuroscience, Spain
2010 - 2010	Public outreach. Event to raise funding for rare diseases Concert	One in a Million Centro de Regulación Genómica, Spain
2010 - 2010	Public outreach. Fair on brain-related experiments Exhibition	Brain fair mNACTEC Museum, Spain
2010 - 2010	Public outreach. Neuromarketing: how marketing influences our choices. Exhibition	Neuromarketing: the brain and decision-making, Centro de Regulación Genómica, Spain
2009/11/10 - 2009/11/11	Soft skills. Course on how to improve competence and confidence when presenting at biomedical conferences.. Workshop	Conference presentation skills Parc de Recerca Biomèdica de Barcelona, Spain
2009/03 - 2009/03	Public outreach. Fair on brain-related experiments. Exhibition	The illusions of the brain (Las ilusiones del Cerebro) Centro de Regulación Genómica, Spain
2008/12 - 2008/12	Public outreach. Fair on brain-related experiments Exhibition	Brain fair Centro de Regulación Genómica, Spain
2008/04 - 2008/04	Public outreach. Workshops on brain-related experiments Exhibition	Museums night (Nits dels Museus) Cosmocaixa Barcelona, Spain
2007/07/17 - 2007/07/21	Continuous formation. I attended a series of seminars in cognition. Conference	Neuroscience Summer Seminars. Cognition: From Genes to Function Duques de Soria Foundation, Spain
2007/02/14 - 2007/02/16	Continuous formation. I attended a workshop on behaviour pathologies. Workshop	IGC workshop series. Behaviour pathologies: Biological Approaches Instituto Gulbenkian de Ciência, Portugal
2005/02/19 - 2005/02/19	Public outreach. Rett syndrome: What the genes tell us. Seminar	Annual meeting of ANPAR Associação Nacional de Pais e Amigos de Rett (ANPAR), Portugal
2004/07/19 - 2004/07/23	Continuous formation. I attended a postgraduate course on Genes and Neurons. Other	Postgraduate courses. Genes and Neurons Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004/06/03 - 2004/06/04	Continuous formation. I attended a workshop on rodent behaviour testing. Workshop	Introduction to rodent behaviour testing Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2003/10/29 - 2003/10/31	Continuous formation. I attended a workshop on laboratory safety. Workshop	Segurança laboratorial: Biológica, Química e Radiológica Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/06/25 - 2003/06/27	Continuous formation. I attended a postgraduate course on cell and tissue culture techniques. Other	Postgraduate courses: Cell and tissue culture techniques Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/05/29 - 2003/05/30	Continuous formation. I attended a postgraduate course on microscopy Other	Postgraduate course: Light microscopy and advanced imaging, principles and good practice Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2002/09/15 - 2002/09/22	Continuous formation. I attended a practical course on mouse anatomy and embryology. Other	EMBO practical course: Anatomy and Embryology of the Mouse University of Zagreb Faculty of Medicine, Croatia
2002/06/05 - 2002/06/07	Continuous formation. I attended a postgraduate course on microscopy Other	Postgraduate course: Light microscopy and analysis: principles and good practice, including recording images from the microscope Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2002/03/01 - 2002/03/01	Soft skills. I attended a workshop on ethics in animal experimentation. Workshop	Responsible science: Animal experimentation today and in the future. Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/08/13 - 2001/08/31	Continuous formation. I attended the Erasmus Summer Programme on Medical Genetics. Other	Erasmus Summer Programme Erasmus MC, Netherlands
2001/05/21 - 2001/05/25	Continuous formation. I attended the a course on gene mapping. Other	Human Disease Gene Mapping Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/03/25 - 2001/03/31	Continuous formation. I attended a course in Medical Genetics Other	14th Course in Medical Genetics European School of Genetic Medicine, Italy

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/09/25	Stressors in epilepsy: impact of cognition, quality of life and social function. (Thesis) Main arguer	Judit Catalan (PhD) Universitat de València, Spain
2024/01/16	Interneuron characterization in Rett Syndrome: insights from mice prefrontal cortex (Thesis) Main arguer	Isabella Oliveira (Master) Universidade do Minho Escola de Medicina, Portugal
2023/09/18	Dissecting the role of adenosine A2A receptors on neurobehavioral deficits induced by binge-like exposure to ethanol during adolescence. Master in Cellular and Molecular Biology (Thesis) Main arguer	Madalena Piteira (Master) Universidade de Coimbra, Portugal
2022/05	Role of extracelular vesicles in cognitive and motor decline in hyperammonemia and hepatic encephalopathy. Molecular mechanisms and therapeutic implications. (Thesis) Main arguer	Paula Izquierdo (PhD) Universitat de València, Spain Fundación de la Comunidad Valenciana Centro de Investigación Príncipe Felipe, Spain
2020/07/24	Alloparental behavior: the effect of pup exposure on nest building and the role of serotonin. (Thesis) Main arguer	Catarina Pacheco (Master) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Institut du Cerveau et de la Moelle Épinière, France
2020/01/31	The medial amygdala as a key neural centre in maternal aggression. Thesis Member	Maria Abellán Álvaro (PhD) Universitat de Valencia Facultat de Ciències Biològiques, Spain
2019/07/24	Adenosinergic control of fear extinction: the role of adenosine A2A receptors in the basolateral amygdala (Thesis) Main arguer	Vanessa Lourenço (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/23	Characterization of maternal behaviors in mice. Pheromonal control and nonapeptidergic substrate (Thesis) Arguer	Ana Martin Sanchez (PhD) Universitat de València, Spain
2013/12/20	Unraveling the biological role of neudesin, a novel neurotrophic factor (Thesis) Arguer	Ashley da Cruz Novais (PhD) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Committee member

	Activity description Role	Institution / Organization
2010 - 2012	Steering committee of the 8th FENS Forum, chair of the Students Committee Member	8th FENS Forum, Spain
2008 - 2012	Member of the Young Neuroscientists Committee of the Spanish Neuroscience Society (SENC). Member	Spanish Neuroscience Society, Spain

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2022/09/01 - Current	Master in Nursing of Mental and Psychiatric Health.	Neuropsychopathology (Mestrado)	Escola Superior de Enfermagem de Coimbra, Portugal
2022 - Current	Master in Cellular and Molecular Biology	Neuronal Circuits & Behavior (Mestrado)	Universidade de Coimbra, Portugal
2022 - Current	PhD Program in Biomedicine and Experimental Biology	Pathogenic Mechanisms of Disease (Doutoramento)	Universidade de Coimbra, Portugal
2022 - Current	PhD Program in Biomedicine and Experimental Biology	Synapse Assembly, Function and Plasticity (Doutoramento)	Universidade de Coimbra, Portugal
2021/03/26 - Current	Neurobiology and Disease	Cellular and Molecular Biology (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/11/06 - Current	Molecular and Cellular Neurobiology	Cellular and Molecular Biology (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/10/23 - 2023/11/02	Advanced Techniques in Synapse Biology, Cajal course, Bordeaux Neuroscinces School	Neurotrophin modulation of fear extinction in mice (Doctorat)
2021/09/01 - 2022/01/31	Biochemistry of proteins, nucleic acids and lipids.	Bioquímica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09/01 - 2022/01/31	Introduction to the biochemistry laboratory.	Bioquímica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/10/01 - 2019/04/06	Time to Experiment (Hora de Experimentar)	(Ensino básico 1º ciclo)	Associação Semear Talentos, Portugal
2018/09/17 - 2019/04/06	Engineers & Scientists (Engenheiros e Cientistas)	(Ensino básico 1º ciclo)	Associação Semear Talentos, Portugal
2016/04/18 - 2016/04/18	Seminars in Neuroscience	Basic and Applied Neurosciences (Master Universitario)	Universitat de València, Spain
2016/04/15 - 2016/04/15	Biomedicine Research Seminars	Medicine (Licence)	Universitat Jaume I Facultat de Ciències de la Salut, Spain
2014/10 - 2016	Genetic Models	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany
2014/11 - 2015/10	Lab rotation in Behavioral and Molecular Neurosciences	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany
2015/04/15 - 2015/04/15	Molecular and Cellular Neurobiology: Genes	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany
2014/01 - 2015/01	Basic Molecular and Cellular Biology	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Germany
2008 - 2012	Cellular and Molecular Basis of Neural Plasticity, Module 2: Integrative Molecular and Cellular Neurobiology	Interuniversitary Master in Neurosciences (Master Universitario)	Universitat de Barcelona Institute of Neurosciences, Spain
2004 - 2005	Molecules and Cells	Medicine (Licenciatura)	Universidade do Minho Escola de Medicina, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2022/01/01 - Current	Member of the scientific committee of FinRett, a Spanish and Catalan Rett syndrome research fund. Member	FinRett, Spain	FinRett
2022/01/01 - Current	External reviewer for the Cariplo Telethon Alliance call. Evaluator		Fondazione Telethon Fondazione Cariplo

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2024/10/22	Investigadores da Universidade de Coimbra identificaram uma molécula capaz de ajudar na extinção das memórias do medo.	90 segundos de Ciência
2024/04	Evitar el Estrés y la Ansiedad. La especialista: Un avance para anular los miedos.	Revista Saber Vivir (Nº 282)
2024/03/29	Proteínas sem Medo	O Futuro do Futuro, segment on Expresso
2024/02/15	Neutralitzar l'ansietat, el rol d'una proteïna ja coneguda que pot ajudar a nous tractaments.	3CAT TVnews
2015/02/04	Of Rett Syndrome. Interview with Mónica Santos.	Investigación Y Ciencia/Blog de ratones y humanos
2008/06/10	Percursos: Mónica Santos, genetics and brain function.	Percursos : Ciência Hoje

Journal scientific committee

	Journal title (ISSN)	Publisher
2024 - Current	iScience
2024 - Current	J Medicinal Chemistry
2023 - Current	Frontiers in Molecular Neuroscience
2023 - Current	Neurobiology of Stress
2023 - Current	Scientific Reports
2021 - Current	Frontiers in Molecular Neuroscience
2020 - Current	Neurochemical Research
2020 - Current	Psychoneuroendocrinology
2016 - Current	Psychiatry Research (0165-1781)	Elsevier
2016 - Current	Clinical Epigenetics (1868-7083)	Springer-Verlag
2016 - Current	Human Genetics (1432-1203)	Springer-Verlag
2015 - Current	PLoS ONE (1932-6203)	Public Library of Science
2013 - Current	Journal of Neuroscience Research (1097-4547)	Wiley (John Wiley & Sons)
2012 - Current	BMC Neuroscience (1471-2202)	Springer (Biomed Central Ltd.)
2009 - Current	Neuroscience (0306-4522)	Elsevier

Mentoring / Tutoring

	Topic	Student name
2024/03 - 2024/04	Impact of stress immobilization on the amygdala	Leire Rodríguez
2023/09 - 2023/11	Interaction effects of early-life stress and MeCP2 on neurobehavior	Carmen Costas
2022/02 - 2022/04	Inter-individual differences in fear extinction in mice.	Garikoitz Azkona
2019/12 - 2020/02	NT3/TrkC role in the regulation of fear memories.	Elena Martínez

Distinctions

Award

2013	Bi-annual Research Award Ramón Trias Fargas
2010	CGC Genetics Award Professor Doutor Amândio Tavares
2003	Serono Award in Demyelinating Diseases

Other distinction

2019	Marie Sklodowska-Curie Action Seal of Excellence European Commission, Belgium
2018	Marie Sklodowska-Curie Action Seal of Excellence European Commission, Belgium
2015	Special honor on high merit of work 2nd International Conference on FMR1 premutation., Spain
2013	Travel Grant from Portuguese Society for Neurosciences
2006	Best oral presentation Duques de Soria Foundation, Spain