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Nídia de Sousa integrated the ICVS/3B's Associate Laboratory staff as Researcher in 2020 joining a team focus in Neural Trauma and Nervous System Regenerative Medicine. Here, she developed an independent research line that aims to study new therapeutic approaches for spinal cord injury using the modulation of GABA system as main effector. She formed her own team, with independent funding (FCT grant 2021, 50K) and 3 undergraduate students and a research fellow. During her scientific path Nídia worked in different institutes and countries, performed her PhD in the University of Barcelona in Spain (2013-2017), had a collaboration with the European Space Agency in the Netherlands (2015-2016) and worked at NOVA Lisbon University, CEDOC in Portugal (2018-2020) before moving to ICVS in Braga, Portugal. Her CV count with 15 papers (all in the last 6 years, 9 as first author), participation in 10 fully funded research projects (5 are still ongoing, > 700K), more than 130 citations and 15 students supervisions.
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Identification

Personal identification

Full name
Nídia de Sousa

Citation names

  • de Sousa, Nídia

Author identifiers

Ciência ID
401D-F5B7-0EBC
ORCID iD
0000-0002-1895-9530

Email addresses

  • nidiadesousa@med.uminho.pt (Professional)

Addresses

  • ICVS, University of Minho, 4710, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Advanced (C1) Advanced (C1)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Advanced (C1)
Catalan Elementary (A2) Upper intermediate (B2) Beginner (A1) Upper intermediate (B2) Beginner (A1)
Education
Degree Classification
2013 - 2017
Concluded
 PhD in Genetics (Doctor)
Universitat de Barcelona, Spain
" "Role of Hippo pathways in planarians"" (THESIS/DISSERTATION)
 Excellent Cum Laude (Maximum classification)
2011 - 2013
Concluded
 Molecular Genetics (Mestrado)
Universidade de Trás-os-Montes e Alto Douro, Portugal

Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain
""Hippo signaling pathway in planarian regeneration"" (THESIS/DISSERTATION)
 18/20
2008 - 2011
Concluded
 Genetics and Biotechnology (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Thesis title: "Ganglion DNA extraction optimization techniques"." (THESIS/DISSERTATION)
 15/20
Affiliation

Science

Category
Host institution 		Employer
2020 - Current Contracted Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho, Portugal
(...)
2018 - 2020 Postdoc (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa, Portugal
(...)
2015 - 2017 Visiting Researcher (Research) European Space Research and Technology Centre, Netherlands
European Space Agency, France
2013 - 2017 Researcher (Research) Universitat de Barcelona Facultat de Biologia, Spain
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2018 - 2020 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa, Portugal
2014 - 2017 Lecturer (University Teacher) Universitat de Barcelona Facultat de Biologia, Spain
Universitat de Barcelona Facultat de Biologia, Spain
Projects

Grant

Designation Funders
2013 - 2017 Role of Hippo signaling in planarians regeneration and homeostasis - APIF FELLOW (45K)
APIF-UB2013
PhD Student Fellow
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain
Concluded

Contract

Designation Funders
2022 - Current Baclofen molecular Action as a promoter of neuronal recovery after Spinal Cord Injury (50K)
EXPL/MED-FAR/1529/2021
Principal investigator
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - Current The peripheral sympathetic system as a target for immunomodulation in spinal cord injury pathophysiology (50K)
EXPL/MED-PAT/0931/2021
Researcher
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - Current SECRET4SCI – Stem cells secreto as a Therapy in Regenerative Medicine for Spinal Cord Injury (200K)
SCML2021
Researcher
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Santa Casa da Misericórdia de Lisboa
Ongoing
2020 - Current Baclofen as a potential treatment to promote recovery from spinal cord injury (200K)
WFL-ES-03/19
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Wings for Life Spinal Cord Research Foundation
Ongoing
2021 - 2022 Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis (ALS) (250K)
PTDC/MED-NEU/31395/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019 - 2020 The function of induced-senescent cells in spinal cord regeneration (250K)
PTDC/MED-NEU/30428/2017
Post-doc Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2017 Regeneration and tissue renewal of adult tissues: Organizing centers and molecular signals responsible for the body pattern and growth of planarians (260K)
BFU2017-83755-P
PhD Student Fellow
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain
 España Ministerio de Ciencia e Innovación
Concluded
2015 - 2017 Experiment on Planarians Regeneration in Space (100K)
ILSRA-2009-0966
Invited Scientist Fellow
European Space Research and Technology Centre, Netherlands
 International Life Science Research Announcement
Concluded
2014 - 2017 Study of stem cells homeostasis and establishment of planarians pattern to understand the regeneration and renewal of adult tissues. (260K)
BFU2014-56055-P
PhD Student Fellow
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain
 España Ministerio de Ciencia e Innovación
Concluded
2012 - 2014 From the stem cell to the organism: Role of the JNK and Wnt signaling pathways during planarian regeneration (230K).
BFU-2011-22786-P
Master Student Fellow
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain
 España Ministerio de Ciencia e Innovación
Concluded

Other

Designation Funders
2018 - 2018 Role of neutrophils in Tumor development (12K)
Private funding (12.000€)
Post-doc Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Biosurfit SA, Portugal
Biosurfit SA
Outputs

Publications

Book chapter
  1. Adell, Teresa; Barberán, Sara; Sureda-Gómez, Miquel; Almuedo-Castillo, María; de Sousa, Nidia; Cebrià, Francesc. "Immunohistochemistry on Paraffin-Embedded Planarian Tissue Sections". In Methods in Molecular Biology, 367-378. Springer New York, 2018.
    Published • 10.1007/978-1-4939-7802-1_11
Conference poster
  1. Corraliza-Gomez, Miriam; Barbosa, M; Ianni, M; de Sousa, Nídia; Vaz, AR; Salgado, AJ; Brites, D. "INTRATHECAL INJECTION OF miR-124-ENGINEERED SECRETOME FROM ALS MOTOR NEURONS MAY DIFFERENTLY IMPACT ON SEPARATE BRAIN REGIONS". Paper presented in VII Symposium of the Portuguese Glial Network, 2023.
  2. de Sousa, Nídia; Pinho, A; Monterio, S; Liberato, V; Campos, J; Cibrão, J; Santos, D; et al. "Acute Baclofen administration promotes functional recovery after spinal cord injury". Paper presented in INTS: International Neurotrauma Symposium, Berlin, Germany, 2022.
  3. Pinho, Andreia G.; de Sousa, Nídia; Salgado, António J; Silva, Nuno A.; Monteiro,, Susana. "TARGETING MICROGLIA AND NEUTROPHILS ON SPINAL CORD INJURY CONTEXT". Paper presented in 2nd SCI international meeting, Porto, Portugal, 2022.
  4. Pinho, Andreia G.; de Sousa, Nídia; Salgado, António J; Silva, Nuno A.; Monteiro, Susana. "Microglia and neutrophils: immune play-actors on spinal cord injury". Paper presented in Cell Symposia, The neuro-immune axis, Lisbon, Portugal, 2022.
  5. de Sousa, Nídia; Pinho, Andreia; Monteiro, Susana; Liberato, Valentina; Santos, Diogo; Salgado, António. "Acute administration of Baclofen after spinal cord injury improves locomotor behavior, bladder control and modulates the inflammatory response.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal., 2021.
  6. Barbosa, Marta; Santos, M; de Sousa, Nídia; Vaz, Ana Rita; Salgado, António; Brites, Dora. "Intrathecal injection of secretive from anti-miRNA-124-Treated ALS motor neurons in MSOD1 mice shows promise as a therapeutic strategy". Paper presented in V Symposium of Portuguese Glial Network, Coimbra, Portugal., 2021.
  7. Pinho, Andreia G.; de Sousa, Nídia; Salgado, António J; Monteiro,, Susana; Silva, Nuno A.. "MICROGLIA SPEFICIFIC BEHAVIOR ACROSS CENTRAL NERVOUS SYSTEM". Paper presented in V Symposium of the Portuguese Glial Network, Coimbra, Portugal, 2021.
  8. de Sousa, Nídia; Pinho, Andreia; Monteiro, Susana; Santos, Diogo; Campos, Jonas; Silva, Nuno; Barreiro-Iglesias, Antón; Salgado, António J. "Baclofen as a potential treatment to promote recovery from spinal cord injury.". Paper presented in NeRD meeting 2020, ICVS, School of Medicine, University of Minho, Braga, Portugal, 2020.
  9. Santos, Diogo; Marote, Ana; Rocha, Luís; de Sousa, Nídia; Mendes-Pinheiro, Bárbara; Pinho, Andreia; Monteiro, Susana; et al. "Impact of the Secretome of Induced Mesenchymal Stem Cells in Axonal Growth and Spinal Cord Injury Repair". Paper presented in NeRD meeting 2020, ICVS, School of Medicine, University of Minho, Braga, Portugal, 2020.
  10. Pinho, Andreia; de Sousa, Nídia; Lentilhas-Graça, José; Monteiro, Susana; Silva, Nuno. "Microglia-neutrophil interaction in spinal cord injury". Paper presented in NeRD meeting 2020, ICVS, School of Medicine, University of Minho, Braga, Portugal, 2020.
  11. Lentilhas-Graça, José ; Gomes, Eduardo; Afonso, João; Lima, Rui; Pinho, Andreia; Santos, Diogo; de Sousa, Nídia; et al. "Spinal Cord Injury: can recovery be achieved through the spleen?". Paper presented in NeRD meeting 2020, ICVS, School of Medicine, University of Minho, Braga, Portugal, 2020.
  12. Correia, Bruna; Saraiva, Diana; Salvador, Rute; de Sousa, Nídia; Jacinto, António; Braga, Sofia; Cabral, Guadalupe. "Low density neutrophils are associated with a worse prognosis in Breast Cancer". Paper presented in Innovate Competition | iMed Conference, Lisbon, Portugal, 2020.
  13. van Loon, Jack; de Sousa, Nídia; Capriccio, Marcello; Vandersteen, Jeroen; Saló, Emili; Adell, Teresa; Auletta, Gennaro. "Launch effects, static hypergravity and vibrations have long lasting effects on gene expression". Paper presented in The American Society for Gravitational and Space Research (ASGSR), Bethesda, MD, USA, 2018.
  14. Rosseló, M; Cardona, Heura; De Sousa, Nídia; Saló, Emili; Adell, Teresa. "Functional characterisation of up and downstream elements of Hippo pathway in S. mediterranea". Paper presented in International Planarian Meeting, Madison, WI, USA, 2018.
  15. Pascual-Carreras, Eudald; Marín-Barba, Marta; Eckelt, Kay; Herrera-Úbeda, Carlos; de Sousa, Nídia; Saló, Emili; Adell, Teresa. "SMED-BS is a novel peptide which inhibition accelerates regeneration and produces bigger planarians or overgrowths depending on the nutritional status.". Paper presented in The International planarian meeting, Madison, WI, USA, 2018.
  16. Pascual-Carreras, Eudald; Marín-Barba, Marta; Eckelt, Kay; de Sousa, Nídia; Saló, Emili; Adell, Teresa. "Smed-BS is a novel peptide which inhibition produces bigger planarians or overgrowths depending on the nutritional status.". Paper presented in The II catalan annual conference of Biology. Barcelona, Spain., 2018.
  17. de Sousa, Nídia; Saló, Emili; Adell, Teresa ; Adell, Teresa. "Hippo signaling restricts cell plasticity in planarians.". Paper presented in EMBO workshop ‘The Hippo pathway across species and disciplines, Rome, Italy, 2017.
  18. de Sousa, Nídia; Rodríguez-Esteban, Gustavo; Saló, Emili; Adell, Teresa. "Hippo signaling restricts cell plasticity in planarians.". Paper presented in Congreso de la Sociedad Española de Biologia del Desarrollo, Gijón, Spain., 2017.
  19. de Sousa, Nídia; Chocano, Elvira; Saló, Emili; Adell, Teresa. "Hippo signaling controls cell death, cell cycle and differentiation in planarians.". Paper presented in 4th European Meeting on Planarian Biology, Sant Feliu de Guixols, Spain, 2016.
  20. Pascual-Carreras, Eudald; Marín-Barba, Marta; de Sousa, Nídia; Eckelt, Kay; Saló, Emili; Adell, Teresa. "Smed-BS is a novel secreted peptide with an essential role in the control of cell number in planarians.". Paper presented in The 4th European Meeting on Planarian Biology, Sant Feliu de Guixols, Spain., 2016.
  21. Pascual-Carreras, Eudald; Marín-Barba, Marta; de Sousa, Nídia; Eckelt, Kay; Saló, Emili; Adell, Teresa. "Smed-bs is a novel secreted peptide that controls cell number in planarians.". Paper presented in The catalan annual conference of Developmental Biology. Barcelona, Spain., 2016.
  22. de Sousa, Nídia; Cardona, Heura; Saló, Emili; Adell, Teresa. "Hippo signaling controls cell turnover and differentiation in planarians.". Paper presented in Keystone Symposia: The Hippo Pathway: Signaling, Development and Disease, New Mexico, USA, 2015.
  23. Pascual-Carreras, Eudald; Marín-Barba, Marta; de Sousa, Nídia; Eckelt, Kay; Saló, Emili; Adell, Teresa. "Smed-Blitzschnell is a novel gene which modulates proliferation in planarians.". Paper presented in The catalan annual conference of Developmental Biology, Sant Feliu de Guixols., 2015.
  24. de Sousa, Nídia; Saló, Emili; Adell, Teresa. "Planarian yorkie controls apoptosis and neoblast proliferation.". Paper presented in EMBO conference: The molecular and cellular basis of regeneration and tissue repair, Sant Feliu de Guixols, Spain, 2014.
Journal article
  1. Pinho, Andreia G.; Monteiro, Andreia; Fernandes, Sara; de Sousa, Nídia; Salgado, António J.; Silva, Nuno A.; Monteiro, Susana. "The Central Nervous System Source Modulates Microglia Function and Morphology In Vitro". International Journal of Molecular Sciences 24 9 (2023): 7685. http://dx.doi.org/10.3390/ijms24097685.
    Published • 10.3390/ijms24097685
  2. de Sousa, Nidia; Robledo, Diego; González-Llera, Laura; Pinho, Andreia G.; Santos, Diogo J.; Monteiro, Susana; Campos, Jonas; et al. "Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury". Data in Brief 46 (2023): 108809. http://dx.doi.org/10.1016/j.dib.2022.108809.
    Published • 10.1016/j.dib.2022.108809
  3. Lentilhas-Graça, José; Santos, Diogo; Afonso, João; Monteiro, Andreia; Pinho, Andreia; Gomes, Eduardo; Lima, Rui; et al. "The Secretome of Macrophages Has a Differential Impact on Spinal Cord Injury Recovery According to the Polarization Protocol". Inflammation and Regeneration (2023):
    Under revision
  4. de Sousa, Nídia; Pinho, Andreia G.; Monteiro, Susana; Liberato, Valentina; Santos, Diogo J.; Campos, Jonas; Cibrão, Jorge R.; et al. "Acute Baclofen administration promotes functional recovery after spinal cord injury". The Spine Journal (2022): http://dx.doi.org/10.1016/j.spinee.2022.09.007.
    Published • 10.1016/j.spinee.2022.09.007
  5. Barbosa, Marta; Santos, Marta; de Sousa, Nídia; Duarte-Silva, Sara; Vaz, Ana Rita; Salgado, António J.; Brites, Dora. "Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice". Biomedicines 10 9 (2022): 2120. http://dx.doi.org/10.3390/biomedicines10092120.
    10.3390/biomedicines10092120
  6. de Sousa, Nídia; Santos, Diogo; Monteiro, Susana; Silva, Nuno; Barreiro-Iglesias, Antón; Salgado, António J.. "Role of Baclofen in Modulating Spasticity and Neuroprotection in Spinal Cord Injury". Journal of Neurotrauma 39 3-4 (2022): https://doi.org/10.1089/neu.2020.7591.
    Published • 10.1089/neu.2020.7591
  7. Saraiva, Diana P.; Correia, Bruna F.; Salvador, Rute; de Sousa, Nídia; Jacinto, António; Braga, Sofia; Cabral, M. Guadalupe. "Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses". Oncotarget 12 24 (2021): 2388-2403. http://dx.doi.org/10.18632/oncotarget.28135.
    Published • 10.18632/oncotarget.28135
  8. de Sousa, Nídia; Caporicci, Marcello; Vandersteen, Jeroen; Rojo-Laguna, Jose Ignacio; Saló, Emili; Adell, Teresa; Auletta, Gennaro; van Loon, Jack J.W.A.. "Molecular impact of launch related dynamic vibrations and static hypergravity in planarians". npj Microgravity 6 1 (2020): http://dx.doi.org/10.1038/s41526-020-00115-7.
    Published • 10.1038/s41526-020-00115-7
  9. Pascual-Carreras, Eudald; Marin-Barba, Marta; Herrera-Úbeda, Carlos; Font-Martín, Daniel; Eckelt, Kay; de Sousa, Nidia; García-Fernández, Jordi; Saló, Emili; Adell, Teresa. "Planarian cell number depends on Blitzschnell, a novel gene family that balances cell proliferation and cell death". Development (2020): dev.184044. http://dx.doi.org/10.1242/dev.184044.
    Open access • Published • 10.1242/dev.184044
  10. de Sousa, Nídia; Pascual-Carreras, Eudald; Saló, Emili; Adell, Teresa. "Functional characterization of salvador and warts in planarians". Matters (2019): http://dx.doi.org/10.19185/matters.201905000004.
    Open access • Published • 10.19185/matters.201905000004
  11. de Sousa, Nídia; Rodriguez-Esteban, Gustavo; Colagè, Ivan; D’Ambrosio, Paolo; van Loon, Jack; Saló, Emili; Adell, Teresa; Auletta, Gennaro. "Transcriptomic Analysis of Planarians under Simulated Microgravity or 8 g Demonstrates That Alteration of Gravity Induces Genomic and Cellular Alterations That Could Facilitate Tumoral Transformation". International Journal of Molecular Sciences 20 3 (2019): 720. http://dx.doi.org/10.3390/ijms20030720.
    Published • 10.3390/ijms20030720
  12. de Sousa, Nídia; Rodríguez-Esteban, Gustavo; Rojo-Laguna, Jose Ignacio; Saló, Emili; Adell, Teresa. "Hippo signaling controls cell cycle and restricts cell plasticity in planarians". PLOS Biology 16 1 (2018): e2002399. http://dx.doi.org/10.1371/journal.pbio.2002399.
    Published • 10.1371/journal.pbio.2002399
  13. Sousa, Nídia; Adell, Teresa. "Maintenance of Schmidtea mediterranea in the Laboratory". BIO-PROTOCOL 8 19 (2018): http://dx.doi.org/10.21769/bioprotoc.3040.
    Published • 10.21769/bioprotoc.3040
  14. Sousa, Nídia; Adell, Teresa. "Detection of Cell Death in Planarians". BIO-PROTOCOL 8 19 (2018): http://dx.doi.org/10.21769/bioprotoc.3039.
    Published • 10.21769/bioprotoc.3039
  15. González-Sastre, Alejandro; de Sousa, Nídia; Adell, Teresa; Saló, Emili. "The pioneer factor Smed-gata456-1 is required for gut cell differentiation and maintenance in planarians". The International Journal of Developmental Biology 61 1-2 (2017): 53-63. http://dx.doi.org/10.1387/ijdb.160321es.
    Published • 10.1387/ijdb.160321es
Thesis / Dissertation
  1. de Sousa, Nídia. "Role of the Hippo pathway in planarians". PhD, Universitat de Barcelona, 2017. https://www.tdx.cat/handle/10803/406086.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023 GABA system activation immunomodulatory role after spinal cord injury European Society for Clinical Investigation: ESCI
(Czech Republic)
2023 Combined Baclofen + Pregabalin administration as a potential therapy for spinal cord injury European Society for Clinical Investigation: ESCI
(Czech Republic)
2022 ACUTE BACLOFEN ADMINISTRATION PROMOTES FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY Wings for Life annual Meeting 2022
(Online meeting)
2018 SMED-BS is a novel peptide which inhibition accelerates regeneration and produces bigger planarians or overgrowths depending on the nutritional status. International Planarian Meeting
(washington, United States)
2018 Launch effects, static hypergravity and vibrations have long lasting effects on gene expression ELGRA meeting
(Juan-les-Pins, France)
2017 Hippo signaling restricts cell plasticity in planarians. IRB BioMed Seminars
(Barcelona, Spain)
2016 Hippo signaling controls cell death, cell cycle and differentiation in planarians. SCB Developmental Biology Joint Retreat
(Spain)
2016 Smed-BS is a novel secreted peptide with an essential role in the control of cell number in planarians 4th European Meeting on Planarian Biology
(Spain)
2015 The Hippo signaling controls the cell turnover and differentiation in planarians SCB Developmental Biology Joint Retreat
(Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Potential of individual administration of Baclofen and Pregabalin in Spinal Cord Injury recovery
Supervisor of João Dourado, MD student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2023 - Current Multi-omics analysis of secretome effect in a spinal cord injury in vitro system.
Co-supervisor of Teresa Sousa, MsC student
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022 - Current Baclofen Molecular Action as a promotor of Spinal Cord Injury recovery
Supervisor of André Mira, Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2022 - Current GABA, a potential immunomodulator in spinal cord injury
Supervisor of Ariana Silva, MSc student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2022 - Current Combined Baclofen + Pregabalin administration as a potential therapy for spinal cord injury
Supervisor of Marta Ferreira, MSc student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal

Universidade do Algarve, Portugal
2022 - 2022 Lab rotation: "Decoding the mechanisms of action behind baclofen effect: A comparative study of 3 different in vitro models of spinal cord injury"
Supervisor of Henena Cavaleiro, PhD student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2022 - 2022 Role of GABAB activation receptors after a spinal cord injury
Supervisor of Mariana Sousa, BSc student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2022 - 2022 Role of Baclofen in response to a glutamatergic injury using a spinal cord organotypic slice
Supervisor of Joana Gonçalves, BSc student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2022 - 2022 Assessing the role of Baclofen in a physical injury in a spinal cord injury organotypic model
Supervisor of Marta Silva, BSc student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2022 - 2022 Baclofen as a potential therapy after spinal cord injury: will a higher concentration produce better outcomes?
Supervisor of Laura Cainé, MD student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2021/02 - 2021/08 Lab rotation: "Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis (ALS)"
Supervisor of Marta Barbosa, PhD student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2021 Baclofen as a potential therapy for the treatment of Spinal Cord Injury
Supervisor of Valentina Liberato, BSc student
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2019 - 2019 Mechanisms of spinal cord injury repair in zebrafish.
Supervisor of Margarida Caio, BSc student
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017 - 2017 Identification of Hippo pathway target genes in planarian: genes with mitochondrial function
Co-supervisor of Maria Roselló, MSc student
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain
2015 - 2016 Targets of Hippo pathway in planarians
Co-supervisor of Elvira Chocano, MSc student
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain
2014 - 2015 Up-stream regulators of Hippo pathway in planarians
Co-supervisor of Heura Cardona, MSc student
Universitat de Barcelona Departament de Genètica Microbiologia i Estadística, Spain

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 Scientific outreach activity - "Brain awareness week" (2023) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2022 - 2022 Scientific outreach activity - European Research Night (2022) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2019/11 - 2019/11 Scientific outreach activity - Lisbon Area Post-Doc Meeting 2019 (2019/11/14)
Conference (Member of the Organising Committee)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/05 - 2019/05 Scientific outreach activity - "Encontros informais com a Ciência" (2019/05/09)
Round table (Member of the Organising Committee)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018 - 2019 Scientific outreach activity - European Research Night (2018) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2014 - 2014 Staff of “The molecular and cellular basis of regeneration and tissue repair”, EMBO Conference (2014/09 - 2014/09)
Congress
 Universitat de Barcelona Facultat de Biologia, Spain
2011 - 2011 Organization Committee of III National Congress of Genetics and Biotechnology, Portugal. (2011 - 2011)
Congress (Member of the Organising Committee)
 Universidade de Trás-os-Montes e Alto Douro, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022 - 2022 Poster communication: "Acute Baclofen administration promotes functional recovery after spinal cord injury" in International Neurotrauma Symposium, Berlin, Germany
Congress
 INTS: International Neurotrauma Symposium, Berlin, Germany
2021 - 2021 Poster communication "Acute administration of Baclofen after spinal cord injury improves locomotor behavior, bladder control and modulates the inflammatory response." in XVII Meeting of the Portuguese Society for Neuroscience.
Congress
Sociedade Portuguesa de Neurociências, Portugal
2020 - 2020 Poster presentation "Baclofen as a potential treatment to promote recovery from spinal cord injury" in NeRD meeting, ICVS, University of Minho, Braga.
Congress
Universidade do Minho, Portugal
2020 - 2020 Online Course "Human Neuroanatomy", from University of Michigan, USA
Workshop
University of Michigan, United States
2020 - 2020 Online couse: "Fundamentals of Neuroscience", from Harvard University, USA
Workshop
Harvard University Division of Medical Sciences, United States
2017 - 2017 Poster presentation "Hippo signaling restricts cell plasticity in planarians." in: EMBO workshop ‘The Hippo pathway across species and disciplines’. Rome, Italy
Workshop
EMBO workshop, Italy
2017 - 2017 Poster presentation "Hippo signaling restricts cell plasticity in planarians." In: Congreso de la Sociedad Española de Biologia del Desarrollo, Gijón, Spain
Congress
Congreso de la Sociedad Española de Biologia del Desarrollo, Spain
2016 - 2016 Oral communication "Hippo signaling controls cell death, cell cycle and differentiation in planarians." In: SCB Developmental Biology Joint Retreat, Barcelona, Spain
Congress
Societat Catalana de Biología del Desenvolupament, Spain
2016 - 2016 Poster presentation "Hippo signaling controls cell death, cell cycle and differentiation in planarians." In: 3rd European Meeting on Planarian Biology. Sant Feliu de Guixols, Spain.
Meeting
European Meeting on Planarian Biology, Spain
2015 - 2015 Oral communication "The Hippo signaling controls the cell turnover and differentiation in planarians." In: SCB Developmental Biology Joint Retreat, Sant Feliu de Guixols, Spain
Congress
Societat Catalana de Biología del Desenvolupament, Spain
2015 - 2015 Poster presentation "Hippo signaling controls cell turnover and differentiation in planarians." In: Keystone Symposia: The Hippo Pathway: Signaling, Development and Disease, Taos, New Mexico, USA.
Congress
Keystone Symposia, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022 Assessing the role of Baclofen in aphysical injury in a spinal cord injury organotypic model
Supervisor
 Marta Silva (Other)
Universidade do Minho, Portugal
2022 Role of Baclofen in response to aglutamatergic injury using a spinal cord organotypic slice
Supervisor
 Joana Gonçalves (Other)
Universidade do Minho, Portugal
2022 Role of GABAB activation receptors after a spinal cord injury
Supervisor
 Mariana Sousa (Other)
Universidade do Minho, Portugal
2021 Baclofen as a potential therapeutic option for Spinal Cord Injury
Supervisor
 Valentina Liberato (Other)
Universidade do Minho, Portugal

Association member

Society Organization name Role
2018 - Current Development Biology Portuguese Society Member
2012 - Current Genetics Portuguese Society Member
2018 - 2020 Volunteer at: Outdoit - Associação Combater O Cancro
2014 - 2017 Development Biology Spanish Society Member
2014 - 2017 Development Biology Catalan Society Member

Committee member

Activity description
Role 		Institution / Organization
2018 - 2019 CEDOC-NMS PostDoc Committee
Member
 Universidade Nova de Lisboa, Portugal
2010 - 2011 Member of students association of Genetics and Biotechnology degree
President / Vice-president
 Universidade de Trás-os-Montes e Alto Douro, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - 2020 Tissue, cells and molecules Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2019 IGC doctoral program - Cells to Organism. Cells to Organism (Doutoramento) Instituto Gulbenkian de Ciência, Portugal
2014 - 2017 Genetics Engineering Biotechnology (Licenciatura) Universitat de Barcelona Facultat de Biologia, Spain
2014 - 2017 Molecular Genetics Bioengineering (Licenciatura) Universitat de Barcelona Facultat de Biologia, Spain

Interview (tv / radio show)

Program Topic
2022 - 2023 Ciência no Feminino PodCast
2021 - 2021 Café com Ciência - EM/UM Baclofen as a potential therapy for spinal cord injury recovery

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Frontiers in Neuroscience, section Neuropharmacology
2021 - Current Journal of Surgery and Clinical Reports
2021 - Current Genes
2020 - Current International Journal of Environmental Research and Public Health

Mentoring / Tutoring

Topic Student name
2015 - 2016 Frizzled and LRP5/6 as regulators of Wnt signaling in planarians Natalia Jordà
2015 - 2016 Signaling pathways involved in planarians regeneration Maria Gelabert
Distinctions

Award

2021 Prémios Neurociências Santa Casa da Misericórdia de Lisboa 2021
Santa Casa da Misericórdia de Lisboa, Portugal
2019 Seal of Excellence by Marie Sklodowska-Curie actions
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
2018 Cover of Plos Biology January 2018 - de Sousa et al., 2018
Plos Biology, United States
2017 Best Poster Award "Hippo signaling restricts cell plasticity in planarians." (200euros)
Congreso de la Sociedad Española de Biologia del Desarrollo, Spain

Other distinction

2019 "TOP 10% collection" of PLOS Biology journal - de Sousa et al., 2018
Plos Biology, United States
2017 "Cum Laude" - Maximum grade in PhD thesis
Universitat de Barcelona, Spain
2012 Selection for the ERASMUS+ participation