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Diana Martins.
Identification

Personal identification

Full name
Diana Raquel Fernandes Martins

Citation names

  • Martins, Diana

Author identifiers

Ciência ID
411F-DB62-27F7
ORCID iD
0000-0002-1457-8992

Email addresses

  • diana.martins@estescoimbra.pt (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2013
Concluded
 Doctoral Programme in Molecular Genetics and Pathology (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Transition from In Situ to Invasive Breast Carcinoma" (THESIS/DISSERTATION)
 Aproved unanimously and with Distinction
2008
Concluded
 School of Allied Health Sciences of Polytechnic of Porto, Portugal (Licenciatura)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
"Comparison between the molecular profiles of In situ and Invasive Breast Carcinomas" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2016/07/01 - 2018 Research Assistant (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/04/01 - 2016/06/30 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009 - 2012 Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2008/07/01 - 2009/12/01 Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2008/04/01 - 2009/12/01 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007/05/01 - 2008/05/01 Research Trainee (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/09/01 - Current Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2017 - Current Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2011/10/01 - 2019/09/30 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2011/09/01 - 2019/09/30 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Projects

Grant

Designation Funders
2010/01/01 - 2013/12/31 TRANSITION FROM IN SITU TO INVASIVE BREAST CARCINOMAS: IS THE PATHWAY DEPENDENT OR INDEPENDENT FROM BREAST CANCER MOLECULAR PROFILE
SFRH/BD/66152/2009
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/01/01 - 2025/06/30 Projetos I2D – Igniting InterDisciplinarity, projeto M2AI – “Papel do Microambiente e Microbioma no tratamento dos carcinomas de mama triplos negativos - aliados ou inimigos?”
Projetos I2D: Igniting InterDisciplinarity
Principal investigator
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
 Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra
Ongoing
2018/07/01 - 2022/06/30 Definição da estrutura 3D da cromatina no locus CDH1 para identificar mecanismos associados à doença
PTDC/BTM-TEC/30164/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Instituto de Investigação e Inovação em Saúde
UID/BIM/04293/2019
Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2020/08/30 - 2021/08/30 HIDGUP - Hidrocolóide de Galactomanana: Nova abordagem no tratamento de Úlceras de Pressão
Start UP Voucher IAPMEI
Researcher
Agência para a Competitividade e Inovação IP, Portugal
 Agência para a Competitividade e Inovação IP
Concluded
Outputs

Publications

Book
  1. Solorzano, L.; Almeida, G.M.; Mesquita, B.; Martins, D.; Oliveira, C.; Wählby, C.. Whole Slide Image Registration for the Study of Tumor Heterogeneity. 2018.
    10.1007/978-3-030-00949-6_12
Conference abstract
  1. Alves, André; Preguiça, Inês; Barbosa, Adelaide; Vieira, Pedro; Martins, Diana; Nunes, Sara; D. Viana, Sofia; Reis, Flávio. "Blueberry juice improved the metabolic profile in a prediabetic rat model induced by a hypercaloric diet without renoprotection". Paper presented in Nephrology Dialysis Transplantation, 2020.
    10.1093/ndt/gfaa142.p0997
Conference poster
  1. Martins, Beatriz; Aires, Patrícia; Silva, Rita; Esteves, Paulo; Morais, Ana; Silva, Maria; Curado, Mónica; et al. "Digital Pathology and Artificial Intelligence: Applications to cancer pathology and integrated diagnostic". Paper presented in I Congresso BioMedLab, 2023.
  2. Alves, André; Preguiça, Inês; Barbosa, Adelaide; Vieira, Pedro; Martins, Diana; Nunes, Sara; Viana, Sofia D.; Reis, Flávio. "Efeitos renais do sumo de mirtilo num modelo de rato pré-diabético induzido por dieta hipercalórica.". Paper presented in 16º Congresso Português de Diabetes, Viamoura, Portugal, 2020.
Journal article
  1. Alexandra Pinheiro; Diana Martins; Clara Rocha; Fernando Melo; Inês Morais; Inês Colaço; Sara Andrade; et al. "Expression of HER2, CD34, and EBV infection in gastric cancer, do they relate?". Journal of Health Sciences (2024): http://dx.doi.org/10.17532/jhs.2023.2622.
    10.17532/jhs.2023.2622
  2. Daniela Pereira; Diana Martins; Fernando Mendes. "Immunotherapy in Head and Neck Cancer When, How, and Why?". Biomedicines (2022): https://doi.org/10.3390/biomedicines10092151.
    10.3390/biomedicines10092151
  3. Margarida Silva; Diana Martins; Fernando Mendes. "The Role of Immune Checkpoint Blockade in Acute Myeloid Leukemia". Onco (2022): https://doi.org/10.3390/onco2030011.
    10.3390/onco2030011
  4. Ana Ramalho Ribeiro; Tiago Madeira; Goreti Botelho; Diana Martins; Ricardo M. Ferreira; Artur M. S. Silva; Susana M. Cardoso; Rui Costa. "Brown Algae Fucus vesiculosus in Pasta: Effects on Textural Quality, Cooking Properties, and Sensorial Traits". Foods 11 11 (2022): 1561-1561. https://doi.org/10.3390/foods11111561.
    10.3390/foods11111561
  5. "Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.809985.
    10.3389/fmolb.2022.809985
  6. Flávia Miranda; Hugo Prazeres; Fernando Mendes; Diana Martins; Fernando Schmitt. "Resistance to endocrine therapy in HR + and/or HER2 + breast cancer: the most promising predictive biomarkers". Molecular Biology Reports (2022): https://doi.org/10.1007/s11033-021-06863-3.
    10.1007/s11033-021-06863-3
  7. Pereira, C.; Park, J.-H.; Campelos, S.; Gullo, I.; Lemos, C.; Solorzano, L.; Martins, D.; et al. "Comparison of East-Asia and West-Europe cohorts explains disparities in survival outcomes and highlights predictive biomarkers of early gastric cancer aggressiveness". International Journal of Cancer 150 5 (2022): 868-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-85121371701&partnerID=MN8TOARS.
    10.1002/ijc.33872
  8. Ricardo, S.; Canão, P.; Martins, D.; Magalhães, A.C.; Pereira, M.; Ribeiro-Junior, U.; de Mello, E.S.; et al. "Searching for SARS-CoV-2 in Cancer Tissues: Results of an Extensive Methodologic Approach based on ACE2 and Furin Expression". Cancers 14 11 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130783179&partnerID=MN8TOARS.
    10.3390/cancers14112582
  9. Beatriz Henriques; Fernando Mendes; Diana Martins. "Immunotherapy in Breast Cancer: When, How, and What Challenges?". Biomedicines 9 11 (2021): 1687-1687. https://doi.org/10.3390/biomedicines9111687.
    10.3390/biomedicines9111687
  10. Gabriela M Almeida; Carla Pereira; Ji-Hyeon Park; Carolina Lemos; Sofia Campelos; Irene Gullo; Diana Martins; et al. "CD44v6 High Membranous Expression Is a Predictive Marker of Therapy Response in Gastric Cancer Patients". Biomedicines (2021): https://doi.org/10.3390/biomedicines9091249.
    10.3390/biomedicines9091249
  11. Fernando Mendes; Eurico Pereira; Diana Martins; Edgar Tavares-Silva; Ana Salomé Pires; Ana Margarida Abrantes; Arnaldo Figueiredo; Maria Filomena Botelho. "Oxidative stress in bladder cancer: an ally or an enemy?". Molecular Biology Reports (2021): https://doi.org/10.1007/s11033-021-06266-4.
    10.1007/s11033-021-06266-4
  12. Ana Lúcia Silva; Pedro Abreu-Mendes; Diana Martins; Fernando Mendes. "The Impact of Immune Checkpoint-Inhibitors Therapy in Urinary Bladder Cancer". Onco (2021): https://doi.org/10.3390/onco1010002.
    10.3390/onco1010002
  13. Mondlane, E.R.; Abreu-Mendes, P.; Martins, D.; Cruz, R.; Mendes, F.. "The role of immunotherapy in advanced renal cell carcinoma". International Braz J Urol 47 6 (2021): 1228-1242. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115445807&partnerID=MN8TOARS.
    10.1590/S1677-5538.IBJU.2020.0681
  14. Lopes, Catia; Cunha, Ines; Camacho, Catarina; Vareda, Catarina; Lai, Ana; Vilela, Marisa; Mendes, Fernando; Martins, Diana. "Twin-to-twin transfusion syndrome: new macroscopic and microscopic findings". European Journal of Public Health (2021): https://publons.com/wos-op/publon/53778689/.
    10.1093/EURPUB/CKAB120.003
  15. Vareda, Catarina; Camacho, Catarina; Cunha, Ines; Lopes, Catia; Pina, Raquel; Lai, Ana; Vilela, Marisa; Mendes, Fernando; Martins, Diana. "Foetal hydrops: new challenges". European Journal of Public Health (2021): https://publons.com/wos-op/publon/53778690/.
    10.1093/EURPUB/CKAB120.004
  16. Nunes, Ruban; Melo, Carolina; Martins, Diana; Mendes, Fernando. "SARS-CoV-2 laboratory diagnostic methods: a systematic review". European Journal of Public Health (2021): https://publons.com/wos-op/publon/53778692/.
    10.1093/EURPUB/CKAB120.014
  17. Martins, Diana; Mendes, Fernando; Schmitt, Fernando. "Microbiome: A Supportive or a Leading Actor in Lung Cancer?". Pathobiology (2020): 1-10. http://dx.doi.org/10.1159/000511556.
    10.1159/000511556
  18. Silva, D.; Abreu-Mendes, P.; Mourato, C.; Martins, D.; Cruz, R.; Mendes, F.. "Cáncer de próstata, nuevas opciones de tratamiento: inmunoterapia". Actas Urológicas Españolas 44 7 (2020): 458-468. http://dx.doi.org/10.1016/j.acuro.2020.01.009.
    10.1016/j.acuro.2020.01.009
  19. Martins, Diana. "Towards automatic protein co-expression quantification in immunohistochemical TMA slides.". IEEE journal of biomedical and health informatics (2020): https://doi.org/10.1109/JBHI.2020.3008821.
    10.1109/jbhi.2020.3008821
  20. Martins, Diana. "Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet". Nutrients (2020): http://dx.doi.org/10.3390/nu12040881.
    10.3390/nu12040881
  21. Mendes, Fernando,1973-; Martins, Diana, 1985-. "O impacto do exercício físico na inflamação, stress oxidativo e na remodelação do músculo cardíaco". (2020): http://hdl.handle.net/10400.26/31340.
    10.36660/abc.20190735
  22. Martins, Diana. "O Impacto do Exercício Físico na Inflamação, Stress Oxidativo e na Remodelação do Músculo Cardíaco". International Journal of Cardiovascular Sciences (2019): http://dx.doi.org/10.36660/abc.20190735.
    10.36660/abc.20190735
  23. Martins, Diana. "Microenvironment in breast tumorigenesis: Friend or foe?". Histology and Histopathology (2018): http://doi.org/10.14670/HH-18-021.
    10.14670/HH-18-021
  24. Martins, Diana. "The Transcriptomic Landscape of Gastric Cancer: Insights into Epstein-Barr Virus Infected and Microsatellite Unstable Tumors". International Journal of Molecular Sciences (2018): http://dx.doi.org/10.3390/ijms19072079.
    10.3390/ijms19072079
  25. Martins, Diana. "Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system". Journal of Neuroinflammation (2017): http://dx.doi.org/10.1186/s12974-017-0891-9.
    10.1186/s12974-017-0891-9
  26. Martins, Diana. "MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy". Disease Models & Mechanisms (2017): http://dx.doi.org/10.1242/dmm.028571.
    10.1242/dmm.028571
  27. Martins, Diana. "The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers". Amyloid (2017): http://dx.doi.org/10.1080/13506129.2016.1278362.
    10.1080/13506129.2016.1278362
  28. Gonçalves, N. P.; Martins, D.; Saraiva, M. J.. "The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers". Amyloid 24 sup1 (2017): 83-84. http://dx.doi.org/10.1080/13506129.2016.1278362.
    10.1080/13506129.2016.1278362
  29. Martins, Diana. "Overexpression of Protocadherin-10 in Transthyretin-Related Familial Amyloidotic Polyneuropathy". The American Journal of Pathology (2016): http://dx.doi.org/10.1016/j.ajpath.2016.02.020.
    10.1016/j.ajpath.2016.02.020
  30. Martins, Diana. "Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer". BMC Cancer (2015): http://dx.doi.org/10.1186/s12885-015-1266-1.
    10.1186/s12885-015-1266-1
  31. Martins, Diana. "The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype". BMC Cancer (2014): http://dx.doi.org/10.1186/1471-2407-14-734.
    10.1186/1471-2407-14-734
  32. Martins, Diana. "p-mTOR expression is associated with better prognosis in luminal breast carcinoma". Journal of Clinical Pathology (2014): http://dx.doi.org/10.1136/jclinpath-2014-202320.
    10.1136/jclinpath-2014-202320
  33. Martins, Diana. "Metastatic breast cancer: mechanisms and opportunities for cytology". Cytopathology (2014): http://dx.doi.org/10.1111/cyt.12158.
    10.1111/cyt.12158
  34. Martins, Diana. "Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma: Key events in the progression from an in situ to an invasive breast carcinoma". Cell Cycle (2013): http://dx.doi.org/10.4161/cc.25794.
    10.4161/cc.25794
  35. Faria, G.; Cardoso, M.J.; Martins, D.; Bettencourt, H.; Amendoeira, I.; Schimitt, F.. "P-Cadherin as prognostic factor for Loco-Regional relapse in breast cancer,Caderina-P: Valor prognóstico na recidiva loco-regional do cancro da mama". Acta Medica Portuguesa 25 2 (2012): 97-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865977939&partnerID=MN8TOARS.
  36. Martins, Diana. "Molecular phenotypes of matched in situ and invasive components of breast carcinomas". Human Pathology (2011): http://dx.doi.org/10.1016/j.humpath.2010.08.024.
    10.1016/j.humpath.2010.08.024
  37. Martins, Diana. "Oncogenic mutations in gastric cancer with microsatellite instability". European Journal of Cancer (2011): http://dx.doi.org/10.1016/j.ejca.2010.09.008.
    10.1016/j.ejca.2010.09.008
  38. Martins, Diana. "Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions". BMC Cancer (2010): http://dx.doi.org/10.1186/1471-2407-10-483.
    10.1186/1471-2407-10-483
  39. Martins, Diana. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study". Histology and Histopathology (2010): http://doi.org/10.14670/HH-25.963.
    10.14670/HH-25.963
  40. Martins, Diana. "Synergy of combined Doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models". Journal of Translational Medicine (2010): http://dx.doi.org/10.1186/1479-5876-8-74.
    10.1186/1479-5876-8-74
  41. Sousa, B.; Paredes, J.; Milanezi, F.; Lopes, N.; Martins, D.; Dufloth, R.; Vieira, D.; et al. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: An immunohistochemical study". Histology and Histopathology 25 8 (2010): 963-974. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956895496&partnerID=MN8TOARS.
  42. Martins, Diana. "Cytological criteria to predict basal phenotype of breast carcinomas". Diagnostic Cytopathology (2009): http://dx.doi.org/10.1002/dc.21102.
    10.1002/dc.21102
Report
  1. Mariana Freire; Diana Martins; Maria Filomena Botelho; Fernando Mendes. 2022. Biomarkers of resistance mechanisms in innovative lung cancer treatments - A systematic Review. https://doi.org/10.37766/inplasy2022.9.0011.
    10.37766/inplasy2022.9.0011

Other

Other output
  1. Whole slide image registration for the study of tumor heterogeneity. 2019. Solorzano, L.; Mesquita, B.; Almeida, G.M.; Martins, D.; Oliveira, C.; Wählby, C.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85094419171&partnerID=MN8TOARS.
  2. CD44v6 expression is a novel predictive marker of therapy response and poor prognosis in gastric cancer patients. 2018. Carla Pereira; Daniel Ferreira; Carolina Lemos; Diana Martins; Nuno Mendes; Daniela Almeida; Pedro Granja; et al. https://doi.org/10.1101/468934.
    10.1101/468934
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/01 - 2023/03/03 II Congresso BioMedLab, Convento S. Francisco, Coimbra (2023/03/01 - 2023/03/03)
Congress (President of the Organising Committee)
2021/06/17 - 2021/06/19 Organização do Evento Annual Meeting 2021- Global Health- New Trends Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, (2021/06/17 - 2021/06/19)
Congress (Member of the Organising Committee)
 Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2020/06/11 - 2020/06/13 Annual Meeting 2020- Health 4.0: Designing Tomorrow´s Healthcare (2020/06/11 - 2020/06/13)
Congress (Member of the Organising Committee)
 Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2019/07/15 - 2019/07/19 VII Cell Culture and Tissue Training Course “Beyond the Microscope, Culturing Life! (2019/07/15 - 2019/07/19)
Conference (Member of the Scientific Committee)
 Universidade de Coimbra Faculdade de Medicina, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2015/03/06 - 2015/03/06 Moderação no painel "Investigando em Neurociências" integrado V Simpósio Técnico de Anatomia Patológica- Evolução e Novas Perspetivas
Congress
 V Simpósio Técnico de Anatomia Patológica- Evolução e Novas Perspetivas
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Distinctions

Award

2022 First Prize Martim Nicholson Award EPBS Poster Competition
European Association for Professions in Biomedical Sciences, Belgium
2021 Melhor Comunicação Oral- Síndrome de Transfusão Feto-Fetal- Novos Desafios
Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2020 Best Oral communication Annual Meeting 2020- TESty – Typing Easier: an innovate device to characterize blood samples”,
Instituto Politécnico de Coimbra, Portugal
2018 Third Prize at the Martin Nicholson Award EPBS Poster Competition- “FORSSMAN PREVALENCE IN A PORTUGUESE POPULATION SAMPLE AND ITS EXPRESSION IN NORMAL TISSUES”
Instituto Politécnico de Coimbra, Portugal
2012 Best Poster Award in Advanced and Metastatic Breast Cancer
European Society for Medical Oncology, Switzerland