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Identification

Personal identification

Full name
Valentina Riva

Citation names

  • Riva, Valentina

Author identifiers

Ciência ID
4212-8716-02D6
ORCID iD
0000-0002-7686-4230

Email addresses

  • vriva@medicina.ulisboa.pt (Professional)
  • valentina.riva01@universitadipavia.it (Professional)

Telephones

Mobile phone
  • (+351) 932254564 (Personal)

Addresses

  • Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)
  • Calçada da Palma de Baixo 39, 1600-175, Lisboa, Lisboa, Portugal (Personal)

Websites

  • linkedin.com/in/valentina-riva-924574b1 (Professional)
  • @Valenti87505685 (Social media)

Knowledge fields

  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Italian (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2016/10 - 2020/01
Concluded
PhD Program in Genetics, Molecular and Cellular Biology (Doctor of Philosophy)
Università degli Studi di Pavia, Italy
"Antiviral potential coupled to genome stability: the multifaceted roles of DDX3X protein" (THESIS/DISSERTATION)
PhD
2014/10 - 2016/09
Concluded
Molecular Biology and Genetics (Laurea Magistrale)
Università degli Studi di Pavia, Italy
"Development of inhibitors of human RNA helicase DDX3X as broad antiviral agents" (THESIS/DISSERTATION)
Master degree
2011/10 - 2014/10
Concluded
Scienze Biologiche (Bachelor)
Università degli Studi di Pavia, Italy
"Stabilità mitotica di un cromosoma di cavallo con centromero privo di DNA satellite" (THESIS/DISSERTATION)
Bachelor degree
Affiliation

Science

Category
Host institution
Employer
2020/10/01 - Current Postdoc (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2020/02/01 - 2020/09/30 Postdoc (Research) Consiglio Nazionale delle Ricerche Istituto di Genetica Molecolare Luigi Luca Cavalli Sforza, Italy
Consiglio Nazionale delle Ricerche Istituto di Genetica Molecolare Luigi Luca Cavalli Sforza, Italy
Projects

Grant

Designation Funders
2023/05/01 - Current Regulatory RNA-proteins interactions in telomeres (de)protection
10.54499/2022.08332.CEECIND/CP1727/CT0002
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Contract

Designation Funders
2020/10/01 - 2023/04/30 Dissecting the composition and function of the telomeric deoxyribo/ribonucleoprotein: the missing building block of the puzzle
EMBO ALTF 878-2020
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Ongoing

Other

Designation Funders
2020/01/10 - 2020/09/30 RNA processing meets DNA stability
AIRC IG2017-20762
Post-doc Fellow
Consiglio Nazionale delle Ricerche Istituto di Genetica Molecolare Luigi Luca Cavalli Sforza, Italy
Concluded
2016/10/01 - 2020/01/09 Antiviral potential coupled to genome stability: the multifaceted roles of DDX3X
AIRC IG2017-20762
PhD Student Fellow
Consiglio Nazionale delle Ricerche Istituto di Genetica Molecolare Luigi Luca Cavalli Sforza, Italy
Concluded
Outputs

Publications

Journal article
  1. Massimiliano Secchi; Anna; Valentina Riva; Graziano Deidda; Carolina Santonicola; Teresa Maria Formica; Simone Sabbioneda; Emmanuele Crespan; Giovanni Maga. "Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops". Nucleic Acids Research (2024): http://dx.doi.org/10.1093/nar/gkae731.
    10.1093/nar/gkae731
  2. Brai, Annalaura; Riva, Valentina; Clementi, Letizia; Falsitta, Lucia; Zamperini, Claudio; Sinigiani, Virginia; Festuccia, Claudio; et al. Corresponding author: Botta, Maurizio. "Targeting DDX3X Helicase Activity with BA103 Shows Promising Therapeutic Effects in Preclinical Glioblastoma Models". Cancers 13 21 (2021): 5569. http://dx.doi.org/10.3390/cancers13215569.
    Published • 10.3390/cancers13215569
  3. Riva, Valentina; Garbelli, Anna; Casiraghi, Federica; Arena, Francesca; Trivisani, Claudia Immacolata; Gagliardi, Assunta; Bini, Luca; et al. Corresponding author: Maga, Giovanni. "Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases". Nucleic Acids Research 48 20 (2020): 11551-11565. http://dx.doi.org/10.1093/nar/gkaa948.
    Published • 10.1093/nar/gkaa948
  4. Bono, Bartolo; Franco, Giulia; Riva, Valentina; Garbelli, Anna; Maga, Giovanni. Corresponding author: Maga, Giovanni. "Novel Insights into the Biochemical Mechanism of CK1e and its Functional Interplay with DDX3X". International Journal of Molecular Sciences 21 17 (2020): 6449. http://dx.doi.org/10.3390/ijms21176449.
    Published • 10.3390/ijms21176449
  5. Brai, Annalaura; Riva, Valentina; Saladini, Francesco; Zamperini, Claudio; Trivisani, Claudia Immacolata; Garbelli, Anna; Pennisi, Carla; et al. Corresponding author: Maga, Giovanni. "DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins". European Journal of Medicinal Chemistry 200 (2020): 112319. http://dx.doi.org/10.1016/j.ejmech.2020.112319.
    Published • 10.1016/j.ejmech.2020.112319
  6. Riva, Valentina; Garbelli, Anna; Brai, Annalaura; Casiraghi, Federica; Fazi, Roberta; Trivisani, Claudia I.; Boccuto, Adele; et al. Corresponding author: Maga, Giovanni. "Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses". Journal of Medicinal Chemistry 63 17 (2020): 9876-9887. http://dx.doi.org/10.1021/acs.jmedchem.0c01039.
    Published • 10.1021/acs.jmedchem.0c01039
  7. Brai, Annalaura; Boccuto, Adele; Monti, Martina; Marchi, Serena; Vicenti, Ilaria; Saladini, Francesco; Trivisani, Claudia Immacolata; et al. Corresponding author: Botta, Maurizio. "Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor". ACS Medicinal Chemistry Letters 11 5 (2020): 956-962. http://dx.doi.org/10.1021/acsmedchemlett.9b00681.
    Published • 10.1021/acsmedchemlett.9b00681
  8. Brai, Annalaura; Riva, Valentina; Ronzini, Stefania; Botta, Maurizio; Zamperini, Claudio; Borgini, Matteo; Trivisani, Claudia Immacolata; et al. Corresponding author: Botta, Maurizio. "Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X". Molecules 24 21 (2019): 3988. http://dx.doi.org/10.3390/molecules24213988.
    Published • 10.3390/molecules24213988
  9. Riva, Valentina; Maga, Giovanni. Corresponding author: Maga, Giovanni. "From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis". Future Medicinal Chemistry 11 11 (2019): 1357-1381. http://dx.doi.org/10.4155/fmc-2018-0451.
    Published • 10.4155/fmc-2018-0451
  10. Brai, Annalaura; Martelli, Francesco; Riva, Valentina; Garbelli, Anna; Fazi, Roberta; Zamperini, Claudio; Pollutri, Alessandro; et al. Corresponding author: Botta, Maurizio. "DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection". Journal of Medicinal Chemistry 62 5 (2019): 2333-2347. http://dx.doi.org/10.1021/acs.jmedchem.8b01403.
    Published • 10.1021/acs.jmedchem.8b01403
  11. Garbelli, Anna; Riva, Valentina; Crespan, Emmanuele; Maga, Giovanni. Corresponding author: Maga, Giovanni. "How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?". Biochemical Journal 474 10 (2017): 1559-1577. http://dx.doi.org/10.1042/bcj20160772.
    Published • 10.1042/bcj20160772
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/02/20 Antiviral potential coupled to genome stability: the multifaceted roles of the human RNA helicase DDX3X protein Life Science 2020
Università degli Studi di Pavia - Campus Aquae (Pavia, Italy)
2019/09/09 A unique domain for a unique target: a novel strategy to develop selective DDX3X RNA helicase inhibitors to fight emerging viruses Emerging Viruses 2019
St Hilda's College (Oxford, United Kingdom)
2018/09/25 Targeting a host factor to control both human viral infection and insect vector competence: the case of the human RNA helicase DDX3X and the RNA helicase Belle of Aedes albopictus Innovative Approaches for Identification of Antiviral Agents Summer School (IIAAASS)
Hotel Flamingo (Santa Margherita di Pula, Italy)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/12/14 - 2021/12/17 I attented "Telomeres & Telomerase" CSHL meeting (Virtual)
Meeting
Cold Spring Harbor Laboratory, United States
2020/12/18 - 2020/12/18 I was among the partecipants of the virtual conference "COVID-19 studies at the DSB" where my supervisor presented our work giving a talk titled: "The DDX family RNA helicases and SARS-COV-2: targeting host-virus interactions" (Authors: Valentina Riva, Anna Garbelli, Virginia Sinigiani, Bartolo Bono, Rita Berisio, Antonella De Palma, Pierluigi Mauri, Giovanni Maga).
Conference
COVID-19 studies at the DSB
Consiglio Nazionale delle Ricerche Dipartimento di Scienze Biomediche, Italy
2019/09/19 - 2019/09/21 Bartolo Bono was among the partecipants of the Biennial Congress of the Italian Associationof Cell Biology and Differentiation (ABCD) where he presented our work in poster P.C10 titled: "Kinetic characterization of CK1e and DDX3X interplay" (Authors: Bartolo Bono, Giulia Franco, Valentina Riva, Anna Garbelli, Giovanni Maga).
Congress
Biennial Congress of the Italian Associationof Cell Biology and Differentiation (ABCD) 2019
2018/09/09 - 2018/09/12 I was among the partecipants of the EMBO Conference "Enzymes, biocatalysis and chemical biology: The new frontiers" (Pavia, Italy) for which I prepared a poster titled "Targeting a host factor to control both human viral infection and insect vector competence: the case of the human RNA helicase DDX3X and the RNA helicase Belle of Aedes albopictus".
Conference
Enzymes, biocatalysis and chemical biology: The new frontiers
Università degli Studi di Pavia, Italy
2018/09/09 - 2018/09/12 I was among the partecipants of the EMBO Conference "Enzymes, biocatalysis and chemical biology: The new frontiers" where my supervisor presented our work giving a talk titled: "Tales of an hybrid genome: when RNA processing meets DNA stability" (Authors: Anna Garbelli, Valentina Riva, Elisa Mentegari, Emmanuele Crespan, Shana Sturla, Barbara van Loon, Giovanni Maga).
Conference
Enzymes, biocatalysis and chemical biology: The new frontiers
Università degli Studi di Pavia, Italy
2017/06/14 - 2017/06/16 I was among the partecipants of the conference "From single cells to 3D-cell culture" (Milan, Italy) for which I prepared a poster titled: "New insights into DDX3 roles: from RNA viruses to RNA metabolism of human normal and tumor cells".
Conference
From Single Cells to 3D-Cell Culture
The Italian Society of Biophysics and Molecular Biology, Italy
2017/04/10 - 2017/04/12 I was among the partecipants of the "Third international Workshop on Aedes albopictus, the Asian tiger mosquito" organized at Palazzo Bellisomi-Vistarino (Pavia, Italy) and hosted by the University of Pavia. My supervisor presented our work giving a talk titled "Reflections at the mirror: looking back from the host to the vector for new strategies" (Authors: Valentina Riva, Anna Garbelli, Alessandro Di Cosimo, Giuliano Gasperi, Anna Malacrida, Maurizio Botta, Giovanni Maga).
Workshop
The third International Workshop on Aedes albopictus
Università degli Studi di Pavia, Italy

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/07 Targeting DDX3X to develop new effective therapeutic approaches against DDX3X syndrome and glioblastoma
Supervisor
Virginia Sinigiani (Master)
Università degli Studi di Pavia, Italy
2020/09 Development of a new class of inhibitors for the RNA helicase DDX5: a potential antiviral and antitumoral target
Supervisor
Francesca Arena (Master)
Università degli Studi di Pavia, Italy
2020/09 DDX3X as a therapeutic target for antiviral chemotherapy and characterization of two missense mutations present in DDX3X syndrome patients
Supervisor
Emanuele Maria Nola (Master)
Università degli Studi di Pavia, Italy
2018/11 The human RNA helicase DDX3X: a new target for the antiviral chemotherapy
Supervisor
Carla Pennisi (Master)
Università degli Studi di Pavia, Italy
2018/09 The human RNA helicase DDX3X as antitumoral target: correlation between protein level and tumour sensitivity
Supervisor
Francesca Arena (Other)
Università degli Studi di Pavia, Italy
2018/07 Targeting a host factor to control both human viral infection and insect vector competence: the case of the human RNA helicase DDX3X and the RNA helicase Belle of Aedes albopictus
Supervisor
Federica Casiraghi (Master)
Università degli Studi di Pavia, Italy

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/10 - 2020/10 Academic session 2019/2020, Course: Biologia Molecolare II (502270 BIO/11), University of Pavia Scienze Biologiche (Bachelor) Università degli Studi di Pavia, Italy
2018/10 - 2019/10 Academic session 2018/2019, Course: Biologia Molecolare II (502270 BIO/11), University of Pavia Scienze Biologiche (Bachelor) Università degli Studi di Pavia, Italy

Mentoring / Tutoring

Topic Student name
2019/10 - 2021/07 Targeting DDX3X to develop new effective therapeutic approaches against DDX3X syndrome and glioblastoma Virginia Sinigiani
2019/10 - 2020/10 Tutoring of Genetics Biological Sciences students
2018/10 - 2020/09 Development of a new class of inhibitors for the RNA helicase DDX5: a potential antiviral and antitumoral target Francesca Arena
2018/10 - 2020/09 DDX3X as a therapeutic target for antiviral chemotherapy and characterization of two missense mutations present in DDX3X syndrome patients Emanuele Maria Nola
2018/10 - 2019/10 Tutor of Genetics Biological Sciences students
2017/03 - 2018/12 The human RNA helicase DDX3X as antitumoral target: correlation between protein level and tumour sensitivity Francesca Arena
2016/10 - 2018/07 Targeting a host factor to control both human viral infection and insect vector competence: the case of the human RNA helicase DDX3X and the RNA helicase Belle of Aedes albopictus Federica Casiraghi
2017 - 2018 The human RNA helicase DDX3X: a new target for the antiviral chemotherapy Carla Pennisi

Other jury / evaluation

Activity description Institution / Organization
2019/10 - 2020/10 Exam commission member for the exam "Biologia Molecolare II" (502270 BIO/11) Università degli Studi di Pavia, Italy
2018/10 - 2019/10 Exam commission member for the exam "Biologia Molecolare II" (502270 BIO/11) Università degli Studi di Pavia, Italy
Distinctions

Award

2017 Best student award from University of Pavia
Università degli Studi di Pavia, Italy
2011 Best student award from Fondazione Achille e Giulia Boroli (XIII edition)

Other distinction

2020 EMBO Postdoctoral Fellowship ALTF 878-2020
2018 PhD traineeship fellowship DR. N 3237/2017
Università degli Studi di Pavia, Italy